JPH05105611A - Composition for sealing dentine crypt fissure - Google Patents

Abstract

(57) [Summary] [Purpose] Effectively by depositing a calcium salt, which has physicochemical properties similar to that of calcium phosphate analog (hydroxyapatite), which is the main component of enamel, on tooth enamel. Provided is a pit fissure sealing composition capable of sealing a pit fissure. [Structure] An enamel surface of a dentin pit and a fissure comprising an aqueous solution containing (a) an organic acid soluble in water and capable of dissolving enamel on the tooth surface and (b) a sulfate soluble in water A dentinal pit and fissure sealing composition for depositing a water-insoluble or sparingly soluble calcium salt on the dentin to seal the pit and fissure.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a dentin pit and fissure sealing composition. More specifically, a water-insoluble or sparingly soluble calcium salt is deposited on the enamel surface of the pit and fissure to seal the pit and fissure, and to prevent dental caries (cavities). It relates to a composition.

[0002]

2. Description of the Related Art The pits and fissures in the tooth structure are likely to be the starting point for the occurrence of dental caries, and especially for molars, the pits and fissures are complicated and deep. Corrosion tended to significantly reduce the average tooth life.

In order to prevent dental caries from pit fissures, adhesive resins or cements have been proposed as materials for sealing the pit fissures. Adhesive resins that have been developed so far are mainly composed of a mixture of a cyanoacrylate monomer and a methylmethacrylate polymer, or a methacrylate-based monomer and a phosphate ester monomer. As the adhesive cement, glass ionomer cement and carboxylate cement have been used for that purpose. However, all of these resin-based or cement-based materials adhere to the tooth surface by chemical hardening and seal the pit fissures, which are constantly washed by saliva and constantly subjected to physical pressure by chewing. On the receiving tooth surface, breakage is likely to occur due to dissolution of the adhesive portion or deterioration of the filler. On the other hand, plaque and edible pieces are likely to be stagnant at the site where the blocking material has once fallen off, which causes caries on the contrary.

Cement-based materials are easily dissolved by saliva, and it is extremely difficult to keep them in the oral cavity for a long time. Further, there is an important problem that cannot be overlooked in terms of safety, which is an essential property as a medical material, in addition to the problem of effectiveness as a filler. In other words, keeping a chemically synthesized substance that does not originally exist in the human body in saliva, which is extremely soluble, for a long period of time in the oral cavity, which is the entrance of food, means that unpolymerized monomer solution is ingested, There is a risk that chemical reactions such as hydrolysis will occur due to the action of the enzyme or the metal ion dissolved from the metal crown covered with teeth, and that it will be taken in via the mucous membrane and digestive tract. Thus, the materials for sealing pit fissures developed to date have inherently various problems, including safety. Therefore, it has been limited so far to applications to baby teeth that replace permanent teeth and short-term permanent teeth. Moreover, it is necessary to perform a regular check after the treatment because of the risk of breakage, and it can be said that there are problems in terms of its reliability and stability.

[0005]

DISCLOSURE OF THE INVENTION An object of the present invention is to deposit a water-insoluble or sparingly soluble calcium salt on the enamel surface of a dentin pit and fissure to seal the pit and fissure. It is intended to provide a composition for pit and fissure sealing.

Another object of the present invention is to deposit a calcium salt having a physicochemical property on the dentin enamel that has almost the same physicochemical properties as the calcium phosphate analogue (hydroxyapatite) which is the main component of the enamel. It is an object of the present invention to provide a composition for sealing pit fissures, which can effectively close the pits and fissures while eliminating the above-mentioned problems of the previously proposed compositions.

Further objects and advantages of the present invention will be apparent from the following description.

[0008]

According to the present invention, the above objects and advantages of the present invention include: (a) an organic acid that is soluble in water and capable of dissolving tooth surface enamel; and (b) water. Dental pit fissure for sealing the pit fissure by depositing a water-insoluble or sparingly soluble calcium salt on the enamel surface of the dental pit fissure, which consists of an aqueous solution containing soluble sulfate This is accomplished with a sealing composition.

Organic acid (a) used in the composition of the present invention
As described above, it is essential that the water has a property of being soluble in water and capable of dissolving the tooth surface enamel.
Examples of the organic acid (a) include acrylic acid, succinic acid, oxalic acid, tartaric acid, malic acid, citric acid, glycolic acid, malonic acid, pyruvic acid, oleic acid, stearic acid, fumaric acid, benzoic acid, aminobenzoic acid. Acid, EDT
A, linoleic acid, linolenic acid, etc. can be mentioned.
Of these, acrylic acid, malic acid, citric acid or tartaric acid are preferred.

These organic acids can be used alone or in combination of two or more.

The preferred concentration of such organic acid is 1 to 50% by weight as the concentration in the aqueous solution constituting the composition of the present invention.
Is.

The optimum concentration for efficiently dissolving calcium in enamel depends on the type of organic acid, and for example,
Citric acid is preferably 10 to 50% by weight, more preferably 20 to 40% by weight. In the case of acrylic acid, it is preferably 5 to 40% by weight, more preferably 1
It is 0 to 30% by weight.

Sulfate (b) used in the composition of the present invention
Is soluble in water. Examples of such sulfates include sodium sulfate, magnesium sulfate, and ammonium sulfate. Of these, ammonium sulfate is particularly preferable.

These sulfates can be used alone or in combination of two or more.

The preferred concentration of the sulfate is 5 to 50% by weight as the concentration in the aqueous solution constituting the composition of the present invention.
Is. If the sulfate is ammonium, a more preferred concentration is 10-40% by weight.

The composition of the present invention may further contain a calcium salt (c) different from the above components (a) and (b). The calcium salt (c) is contained in an aqueous solution in a dissolved state. As the calcium salt (c), either an organic calcium salt or an inorganic calcium salt can be used. Examples of the inorganic calcium salt include calcium chloride, calcium fluoride,
Calcium bromide, calcium iodide, calcium sulfate,
Calcium nitrate, calcium carbonate, calcium hydroxide,
Examples thereof include calcium phosphate, calcium hydrogen phosphate, calcium dihydrogen phosphate, and hydroxyapatite. Examples of the organic calcium salt include calcium acetate, calcium methacrylate, calcium lactate,
Examples thereof include calcium glycerate, calcium propionate, calcium tartrate and the like. Such calcium salts can be used alone or in combination of two or more. As the calcium salt, especially calcium sulfate,
Calcium phosphate, calcium chloride, calcium fluoride or hydroxyapatite are preferred.

Calcium dissolved in the aqueous solution reacts with sulfate radicals in the aqueous solution to form calcium sulfate, but nevertheless, when calcium remaining in the aqueous solution and remaining remains on the surface of tooth enamel. It promotes the production of calcium salts that are deposited and deposited on the surface.

The preferred concentration of the calcium salt (c) is 50% by weight or less, more preferably 0.01 to 10% by weight, as the concentration in the aqueous solution constituting the composition of the present invention.

A water-insoluble or sparingly soluble calcium salt obtained by applying the composition of the present invention to a dentin pit and fissure has a physicochemical property similar to that of calcium phosphate which is a main component of enamel. Thing (hydroxyapatite)
Since it is almost the same as the above, it has excellent properties in the following points as compared with the conventional pit and fissure sealing material.

(1) Excellent safety: First of all, safety is essential for materials used for the human body, especially for medical materials used in the oral cavity. Since the conventional material is a chemically synthesized substance, as described above, there is a risk of chronic toxicity for use in the oral cavity and it cannot be said to be 100% safe. But,
Since the composition of the present invention provides a material equivalent to that of hydroxyapatite, which is a main component of teeth, that is, a calcium phosphate analog, it is extremely safe to retain in the oral cavity constantly exposed to saliva for a lifetime.

(2) Excellent chemical stability: Conventional materials undergo chemical changes due to salivary enzymes and metal ions,
It was deteriorated by being constantly immersed in a solution called saliva, and lacked chemical stability. However, the composition of the present invention, without causing such a negative chemical change,
It is extremely stable in the oral cavity. That is, saliva contains supersaturated calcium ions. Therefore, calcium tends to always deposit on the tooth surface in the oral cavity. For example, tartar that is often seen on the tooth surface is a good example. Therefore, the composition of the present invention that gives crystals of calcium salts similar to teeth and tartar is extremely stable in saliva containing supersaturated calcium ions once the deposit is once provided on the tooth surface in the oral cavity. .. Rather, using it as a source, calcium crystals deposit on the surface of the filling material and reinforce it. Then, the excessively reinforced and deposited portion is appropriately abraded and removed by chewing, and an appropriate thickness is relieved. In this way, once deposited in the pit and fissure, it can be kept in a very stable state for a lifetime by a natural mechanism without artificial modification. It is an excellent medical material that has an ideal stability maintaining system similar to the function of human homeostasis.

(3) Excellent physical stability: The mechanism of adhesion of the composition of the present invention to the tooth surface is not merely adhesion having an interface between two substances as in conventional materials, but stronger. is there. That is, since the calcium salt crystals grown from the crystals on the tooth enamel surface are stacked to close the pit fissures, they are more firmly bonded and attached to the enamel. Further, as described in the section (2), the deposit formed by the composition of the present invention is chemically extremely stable in saliva, and rather tends to be reinforced. Therefore, it is physically stable without breaking or falling off from the tooth surface.

(4) High reliability: Since conventional materials may break or dissolve during long-term use, plaque and edible pieces tend to be deposited on the contrary. Regular dentist checks are necessary as they can be easily eroded. However, the deposit by the composition of the present invention is extremely low in risk and highly reliable because of the reasons (2) and (3) described above. Etc. are advantageous.

[0024]

The present invention will be described in detail with reference to the following examples, but the present invention is not limited to the following examples.

Example 1 35% by weight of citric acid and 14% by weight of ammonium sulfate
An aqueous solution containing 1 was prepared. The surface of the bovine tooth was polished with # 600 emery paper to expose the enamel. The above aqueous solution was dropped on the exposed surface and treated for 3 minutes. After thoroughly washing with distilled water, it was dried by blowing dry air and observed with a scanning electron microscope. A scanning electron micrograph is shown in FIG. It was confirmed that crystals were densely deposited and completely covered the bovine surface.

Example 2 1.1% by weight of hydroxyapatite was added to an aqueous solution of 35% by weight of citric acid and 14% by weight of ammonium sulfate. Although a precipitate was formed, the same procedure as in Example 1 was carried out using the supernatant. The scanning electron micrograph is shown in Figure 2.
It was shown to. The crystal morphology that has been deposited is different from that in Fig. 1, but
It was observed that it completely covered the bovine tooth surface.

Further, when an acrylic rod was adhered to the crystal and the adhesion strength between the bovine tooth surface and the crystal was measured, it was 0.96 ± 0.39 MPa in the case of Example 1, whereas that of Example 2 was measured. It was found that the bond strength to the bovine tooth surface was improved to 5.45 ± 0.74 MPa.

[0028]

The dentin pit fissure treated with the composition of the present invention is blocked by the precipitated calcium salt, and this salt does not dissolve in saliva under normal oral conditions. Suppress the occurrence of dental caries.

[Brief description of drawings]

FIG. 1 of the accompanying drawings is a scanning electron microscope photograph for observing crystal morphology (structure) deposited on the surface of bovine teeth treated with the composition of the present invention (Example 1).

FIG. 2 is a scanning electron micrograph observing crystal morphology (structure) deposited on the surface of bovine teeth treated with another composition of the present invention (Example 2).

Front Page Continuation (72) Inventor Narimichi Honda Narumi 6-1-2, Waki, Kuga-gun, Yamaguchi Prefecture Mitsui Petrochemical Industries, Ltd. (72) Inventor, Kazumasa Murazu 12-10, Onimaru-cho, Saga, Saga

Claims (8)

[Claims] 1. An enamel of dentin pit and fissure comprising an aqueous solution containing (a) an organic acid that is soluble in water and can dissolve enamel on the tooth surface and (b) a sulfate salt that is soluble in water. A dentin pit and fissure sealing composition for depositing a water-insoluble or sparingly soluble calcium salt on a dentin surface to seal a pit and fissure. 2. The composition according to claim 1, wherein the aqueous solution further contains (c) a calcium salt in a dissolved state. 3. The composition according to claim 1, wherein the organic acid (a) is acrylic acid, malic acid, citric acid or tartaric acid. 4. The composition according to claim 1, wherein the sulfate (b) is ammonium sulfate. 5. The composition according to claim 1, wherein the calcium salt (c) is calcium sulfate, calcium phosphate, calcium chloride, calcium fluoride or hydroxyapatite. 6. The composition according to claim 1, wherein the organic acid (a) is contained in an aqueous solution in an amount of 1 to 50% by weight. 7. The composition according to claim 1, which contains the sulfate (b) in an aqueous solution in an amount of 5 to 50% by weight. 8. The composition according to claim 2, wherein the calcium salt (c) is contained in the aqueous solution in an amount of 50% by weight or less.