JPH0568710A - Ultrafiltration control and supervision system of dialyzator - Google Patents

Abstract

(57) [Abstract] [Purpose] In a dialysis machine equipped with an ultrafiltration control mechanism, for clogging of the dialysis membrane of the dialyzer, changes in plasma osmotic pressure, changes in ultrafiltration rate, changes in blood flow rate, etc. Always perform proper and highly accurate ultrafiltration control monitoring. [Structure] The outlet pressure or inlet pressure is detected on the blood side of the dialyzer, the outlet pressure or inlet pressure is detected on the dialysate side of the dialyzer, and the ultrafiltration rate (UFR) is calculated from these detected pressures, The amount of change in the ultrafiltration rate at a certain time point is compared with the amount of change in the ultrafiltration rate before that time point, and this comparison value is collated with a preset alarm condition.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dialysis machine equipped with an ultrafiltration control mechanism, and particularly to an ultrafiltration control for monitoring a failure of the ultrafiltration control mechanism due to a failure of the ultrafiltration control mechanism during dialysis treatment. Regarding monitoring system.

[0002]

2. Description of the Related Art Today, dialysis machines are widely used as devices for performing dialysis therapy for patients with chronic renal failure. This dialysis therapy is a means necessary for maintaining the life of removing water that has been eaten and drink (generally called ultrafiltration), especially for patients who do not produce urine, and the existence of a dialysis device is extremely important.

Recently, a high-performance dialyzer (dialyzer) has been developed to enable a large amount of ultrafiltration. On the other hand, if the ultrafiltration control is mistaken, excess water is removed or sufficient water is removed. There is a risk that it will not be possible to remove water, which may endanger the life of the patient.Therefore, it is required that the dialysis machine has a function capable of performing proper and safe ultrafiltration control. Became.

From this point of view, a dialysate equal flow circuit using a double pump for equalizing the dialysate flow rate flowing into the dialyzer and the dialysate flow rate flowing out from the dialyzer is constructed. A dialysis apparatus having an ultrafiltration control mechanism provided with an ultrafiltration pump capable of removing a predetermined amount of liquid and removing an equivalent amount of water from the blood side of a dialyzer has been developed.

Therefore, in this type of dialysis device, when an arbitrary ultrafiltration amount is set, a liquid commensurate with the ultrafiltration amount is removed via the ultrafiltration pump according to the set value. Ultrafiltration errors due to performance variations can be ignored, and accurate ultrafiltration can be achieved. However, even with this type of dialysis machine, if it is operated for a long time, the dialyzer membrane of the dialyzer may become clogged, and dust from the diaphragm of the back pressure valve may leak due to the inclusion of carbonate deposits, etc. Wear and the like becomes difficult to perform accurate ultrafiltration control,
There is a risk of poor ultrafiltration. For this reason, in the conventional dialysis apparatus, a monitoring method is employed in which a phenomenon that causes a failure in ultrafiltration is detected by a change in dialysate pressure.

FIG. 5 is a schematic system diagram showing an example of the configuration of a dialysis machine equipped with an ultrafiltration control mechanism which is currently in practical use. In FIG. 5, reference numeral 10 indicates a dialyzer, and the dialysate side defined by the dialyzer 10 a of the dialyzer 10 has a dialysate supply system 14 that forms an equal flow rate circuit via a double pump 12. And the dialysate drainage system 16 are connected. In this case, the compound pump 12 is composed of a reciprocating pump having a single plunger and two pump portions 18a and 18b of the same volume which alternately perform suction and discharge operations. In addition, close to the dialyzer 10,
The inlet and outlet of the dialyzer 10 are short-circuited to the dialysate supply system 14 and the dialysate drainage system 16 via electromagnetic switching valves, respectively. The dialysate drainage system 16 is provided with a pressurizing pump 22 at a connection point between the bypass pipe 20 and the double pump 12, and an ultrafiltration pump is provided downstream of the pressurizing pump 22 via a deaeration chamber 24. An ultrafiltration system 28 with 26 is branched and connected. In this case, a back pressure valve is provided on the discharge side of each of the double pump 12 and the ultrafiltration pump 26, and the back pressure of each pump is set to be maintained at a predetermined value so that the discharge flow rate of each pump is constant. Can be held at. In this case, the degassing chamber 24
Connects the degassing pipe 30 led out via the electromagnetic on-off valve to the dialysate drainage system 16 on the downstream side of the dual pump 12. On the other hand, a blood system 34, which is connected to the patient K via a blood pump 32, is connected to the blood side of the dialyzer 10 defined by the dialysis membrane 10a. In the dialyzer configured in this way, a dialysate pressure sensor 36 for measuring the dialysate pressure is attached upstream of the pressurizing pump 22 to the dialysate drainage system 16, and the blood system 34 is connected to the vein. A venous pressure sensor 38 is attached to the side and is used as a monitoring mechanism during dialysis treatment described later.

However, in the dialysis apparatus having the above structure, the bypass pipe 20 is shut off to connect the dialysate supply system 14 and the dialysate drainage system 16 to the dialyzer 10, and the double pump 12 and the pressurizing pump 22 are connected. And ultrafiltration pump 26
To drive the blood pump 32 to supply the blood of the patient K to the dialyzer 10 for dialysis treatment. In this case, the flow rate of the dialysate supply system 14 and the flow rate of the dialysate drainage system 16 of the dialysate are equal, and these dialysate systems form an equal flow circuit. Therefore, if a predetermined amount of ultrafiltration is removed from the dialysate drainage system 16 to the ultrafiltration system 28 by driving the ultrafiltration pump 26, the dialysis membrane 10a of the dialyzer 10 is removed.
The same amount of water as the ultrafiltration amount can be removed from the blood side to the dialysate side through. The ultrafiltration pump 2
The ultrafiltration system 28 with 6 can also be provided in the dialysate supply system 14.

Further, as a dialysis machine equipped with an ultrafiltration control mechanism, one utilizing a diaphragm chamber (Japanese Patent Publication No. 56-56).
No. 82) and a device using a viscous chamber (Japanese Patent Laid-Open No. 1-280468) are currently in practical use.

Therefore, the conventional ultrafiltration control monitoring system M controls the dialysate flow rate QDi flowing into the dialyzer 10 and the dialysate flow rate QDo flowing out from the dialyzer 10 as schematically shown in FIG. , The blood flow rate QBi flowing into the dialyzer 10 and the blood flow rate QBo flowing out of the dialyzer 10 are controlled to control the ultrafiltration amount of the patient K, and thereby the outlet pressure PDo of the dialyzer side dialyzer 10 is adjusted. The following ultrafiltration control monitoring is basically performed with a certain drainage system pressure and a venous pressure which is the outlet pressure PBo of the dialyzer 10 on the blood side.

(1) Upper and lower limit alarm levels of a predetermined width are set for the dialysate pressure during dialysis treatment, and an alarm is generated when the dialysate pressure changes by the predetermined range or more. (2) The ultrafiltration pressure (TMP) of the dialysis membrane of the dialyzer is calculated from the venous pressure and the dialysate pressure during dialysis treatment, and this TMP is calculated.
The upper and lower limit alarm levels of a predetermined width are provided, and an alarm is generated when the TMP changes by more than the predetermined width.

That is, in the above-mentioned conventional dialysis apparatus, as a standard for evaluating its performance, the ultrafiltration rate (UF) is used.
R) is used. Generally, this ultrafiltration rate (UFR)
Is expressed by the following approximate expression from the relationship with the ultrafiltration pressure (TMP).

[0012]

[Equation 8]

Here, Δp is the pressure gradient inside and outside the membrane, and is represented by the following equation as an approximate value.

[0014]

[Equation 9]

However, in actual measurement, the blood side monitors the venous pressure (PBo) and the dialysate side monitors the drainage system pressure (PDo).
Can be monitored and can be estimated by the following equation. TMP (= Δp) = PBo−PDo (4) TMP = PBo−PDo + α (5) Therefore, in the related art, the dialysate pressure sensor 36 and the vein provided in the above-described dialyzer shown in FIG. 6 are conventionally used. With the pressure sensor 38, the safety management of the dialysis machine based on the abnormality of the ultrafiltration rate (UFR) is carried out.

The change with time of the TMP in a normal dialysis machine is as shown in FIG. That is, TMP
Draws a gentle rising curve over time as shown by the solid line. Therefore, in this case, the variable range a ₁ that allows the change of TMP from the dialysis start time t ₁ to the dialysis end time t ₃
~ A ₂ That is, the upper and lower limit alarm levels are set and measured T
When the MP exceeds the variable range, an alarm can be generated to notify the dialysis abnormality. Therefore, in the prior art, for example, in consideration of the above-mentioned variable range, the dialysate pressure sensor 36 and the venous pressure sensor 38 are set to the permissible limit values of the dialysate pressure and the venous pressure, respectively, and the measured values of the respective sensors are respectively set. A convenient method such as issuing an alarm when the set limit value is exceeded is adopted.

[0017]

However, in today's dialysis therapy, it is necessary to adapt to the physiological condition of the patient.
At the doctor's discretion, the ultrafiltration rate is changed (generally, the ultrafiltration rate is increased) during the dialysis treatment. In this case, as indicated by the broken line in FIG. 7, the TMP exceeds the variable range a ₂ (upper limit alarm level) at the time point t ₂ of changing the ultrafiltration rate, resulting in an erroneous alarm. In order to avoid such a situation, it is necessary to increase the upper limit of the variable range of the TMP, but if the range of the variable range of the TMP is widened in this way, for example, the ultrafiltration control mechanism may fail. In this case, since a relatively large excess or deficiency of the ultrafiltration amount is allowed, there is a drawback that the influence on the patient becomes extremely large. Further, despite the normal operation of the ultrafiltration control mechanism, the dialysis membrane of the dialyzer is clogged, the osmotic pressure of the plasma is changed, the blood flow rate is changed, etc., and an erroneous alarm is generated as described above. There are difficulties.

Therefore, an object of the present invention is, in a dialysis machine equipped with an ultrafiltration control mechanism, a change with time of the ultrafiltration rate (UFR) and a change with time of the plasma osmotic pressure due to clogging of the dialysis membrane of the dialyzer. An object of the present invention is to provide an ultrafiltration control monitoring system for a dialysis machine, which is capable of performing smooth and safe dialysis treatment without being affected by changes in blood flow rate and changes in ultrafiltration rate.

[0019]

An ultrafiltration control monitoring system for a dialysis machine according to the present invention is a dialysis machine equipped with an ultrafiltration control mechanism, wherein the ultrafiltration pressure (TMP) to the dialysis membrane of the dialyzer and the ultrafiltration pressure are limited. The ultrafiltration rate (UFR) is continuously calculated from the ultrafiltration rate (v), and the change amount of the ultrafiltration rate at a certain time point is compared with the change amount of the ultrafiltration rate before that time point. It is characterized in that arithmetic means is provided to generate an alarm when the comparison value meets a preset alarm condition.

In the above ultrafiltration control monitoring system, the calculating means is an ultrafiltration rate (UFR) of the dialyzer.
The ultrafiltration pressure (TMP) is calculated from the outlet pressure (PBo) on the blood side of the dialyzer and the outlet pressure (PDo) on the dialysate side by the following formula 10, and the ultrafiltration pressure (TMP) and the It can be calculated from the outer filtration rate (v) by the following formula 11.

[0021]

[Equation 10]

[0022]

[Equation 11]

Further, the computing means calculates the ultrafiltration rate (UFR) of the dialyzer as the inlet pressure (P) on the blood side of the dialyzer.
Bi) and the inlet pressure (PDi) on the dialysate side, the ultrafiltration pressure (TMP ') is calculated by the following equation 12, and from this ultrafiltration pressure (TMP') and the ultrafiltration speed (v). It can also be calculated by the following formula 13.

[0024]

[Equation 12]

[0025]

[Equation 13]

Further, the calculating means calculates the ultrafiltration rate (UFR) of the dialyzer, the outlet pressure (PBo) and the inlet pressure (PBi) on the blood side of the dialyzer, and the outlet pressure (PDo) and the inlet pressure on the dialysate side. From (PDi), the pressure gradient (Δp) is calculated by the following equation 14, and the ultrafiltration pressure (TMP) is calculated from the pressure gradient (Δp) by the following equation 15, and the ultrafiltration pressure (TMP) and the ultrafiltration pressure are calculated. From the filtration rate (v), the following equation 16
It can also be calculated by

[0027]

[Equation 14]

[0028]

[Equation 15]

[0029]

[Equation 16]

In this case, as the calculation means, either the average pressure on the blood side or the average pressure on the dialysate side is set as the arterial pressure (PBi) or venous pressure (PBo), or the supply system pressure (PDi) or It is also possible to calculate the ultrafiltration rate (UFR) of the dialyzer by using it as the drainage system pressure (PDo) and performing the calculation according to the above equations 14 to 16.

The calculation means calculates the change amount (ΔUFRt _n ) of the ultrafiltration rate of the dialyzer at a certain time point (t _n ),
The ultrafiltration rate at that time and a predetermined time interval (Δ
t) It can be calculated as a deviation from the ultrafiltration rate at the previous time point (t _n −Δt ₁ ). Then, the calculating means is configured to correct the disturbance α from the ultrafiltration pressure of the dialysis membrane of the dialyzer when the ultrafiltration rate is 0,
An accurate ultrafiltration rate (UFR) can be calculated.

Further, it is preferable that the predetermined time interval (Δt) in the calculation means is set small after the start of dialysis and set large as the dialysis progresses, and the alarm condition in the calculation means is immediately after the start of dialysis. It is preferable that the value is set gently and the value is set strictly as dialysis progresses.

[0033]

According to the ultrafiltration control monitoring system of the dialyzer according to the present invention, the outlet pressure or the inlet pressure is detected from the blood system connected to the blood side of the dialyzer and the equal flow rate is connected to the dialysate side. The dialysate pressure is detected from a part of the circuit, and the ultrafiltration rate (UFR) of the dialyzer membrane of the dialyzer is continuously calculated from the detected blood pressure and dialysate pressure to determine the ultrafiltration rate at a certain point. By comparing the amount of change and the amount of change in the ultrafiltration rate immediately before that and collating this with a preset alarm condition, it is possible to easily and accurately monitor the appropriate state of the ultrafiltration control. it can.

In particular, in the present invention, changes in the ultrafiltration rate due to clogging of the dialyzer membrane of the dialyzer, changes in plasma osmotic pressure with time, changes in blood flow rate and changes in ultrafiltration rate are considered. The superfiltration control can be effectively monitored, and the performance of the dialysis apparatus of this type can be improved and the safety of the ultrafiltration control can be further improved.

[0035]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A preferred embodiment of the ultrafiltration control monitoring system for a dialysis machine according to the present invention will be described in detail below with reference to the accompanying drawings.

FIG. 1 is a characteristic diagram showing the ultrafiltration rate (UFR) of a dialyzer monitored by the ultrafiltration control monitoring system according to the present invention together with the change of dialysis time.

Here, the amount of change in the UFR value with respect to the change in dialysis time is calculated. That is, UF at time t _n
The amount of change in R value ΔUFRt _n is calculated as UFR at time t _n .
Determined by _- (Δt ₁ UFRt _n) and the following equation (6) _- the value (UFRt _n) and the time t _n UFR value in Delta] t _{1. ΔUFRt n = UFRt n - (UFRt} n - Δt 1) ......... (6) The time t _{n -} amount of change UFR value in Delta] t ₁ delta
(UFRt _{n -} Δt _1), and time t _{n -} UFR values at _{Δt 1 (UFRt n - Δt 1} ) and the time t _{n -} UFR values at _{Δt 2 (UFRt n - Δt 2} ) and the following equation (7)
Ask by. Δ (UFRt _n −Δt ₁ ) = (UFRt _n −Δt ₁ ) − (UFRt _n −Δt ₂ ) ... (7) Then, the change amount ΔUFRt of the UFR value obtained here
Comparing _n with Δ (UFRt _n −Δt ₁ ), and if this comparison value meets a preset alarm condition, an arithmetic circuit is configured to perform an alarm operation.

Further, as for the characteristic of the UFR value, as shown in FIG. 2, the decrease rate is large immediately after the start of dialysis, and the decrease rate becomes smaller as the dialysis time elapses. Therefore, the sensitivity of the ultrafiltration control monitoring system during dialysis treatment can be maintained in the same state by adjusting the time interval Δt or the alarm condition corresponding to the change in the UFR value as follows. (A) The time interval Δt is reduced after the start of dialysis and increased as the dialysis progresses. (B) The alarm condition is made gentle immediately after the start of dialysis and becomes stricter as dialysis progresses.

Next, a method of calculating the UFR value will be described.

Calculation Method of UFR Value (1) As shown in FIG. 3, the outlet pressure on the blood side of the dialyzer 10, that is, venous pressure (PBo), and the outlet pressure on the dialyzer side of the dialyzer 10, that is, the drainage system pressure (PDo). ) And are detected by the venous pressure sensor 40 and the drainage system pressure sensor 42, respectively, and these detected values are substituted into the equation (4) to calculate the ultrafiltration pressure TMP value. Filtration speed v
Is substituted into the equation (1) to calculate the UFR value.

Calculation Method of UFR Value (2) As shown in FIG. 4, in order to reduce calculation errors due to pressure loss occurring on the blood side and dialysate side of the dialyzer 10, the outlet pressure and inlet of the dialyzer 10 on the blood side are reduced. Pressure, that is, venous pressure (PBo) and arterial pressure (PBi), and outlet pressure and inlet pressure of the dialyzer 10 on the dialysate side, that is, drainage system pressure (PDo) and supply system pressure (PDi), respectively. And the arterial pressure sensor 44, the drainage system pressure sensor 42, and the fluid supply system pressure sensor 46, and the detected values are substituted into the above equation (3) to obtain the pressure gradient Δ.
p is calculated, and the TMP value is obtained based on the equation (4).
The UMP value is calculated by substituting the TMP value and the ultrafiltration rate v into the equation (1).

Correction of Disturbance α In the above UFR value calculation methods (1) and (2), when calculating the TMP value, the disturbance α is calculated from the TMP value of the dialysis membrane of the dialyzer when the ultrafiltration rate v is 0. The correction is carried out by the equations (5) and (2) to obtain the TMP value, and the UFR value is calculated based on the TMP value. As a result, an accurate UFR value can be calculated. In particular, in this case, it is possible to accurately calculate the negative UFR value that causes reverse ultrafiltration in which the liquid moves from the dialysate side to the blood side.

Other Method for Calculating UFR Value (a) In contrast to the method for calculating UFR value (1) shown in FIG. 3, the inlet pressure on the blood side of the dialyzer 10, that is, the arterial pressure (PBi) and the dialysis of the dialyzer 10. The inlet pressure on the liquid side, that is, the liquid supply system pressure (PDi) is detected by providing corresponding pressure sensors (see FIG. 4), and these detected values are substituted into the equation according to the above equation (4) to determine the limit. The ultrafiltration pressure (TMP ') is calculated, and the ultrafiltration pressure (TMP') and the ultrafiltration speed v
Can be substituted into the equation (1) to calculate the UFR value. Thus, as a method of calculating the ultrafiltration pressure,
Even if the arterial pressure (PBi) is used in place of the venous pressure (PBo) and the liquid supply system pressure (PDi) is used in place of the drainage system pressure (PDo), only the flow path specific resistance is different. Intended UF
It is possible to monitor the amount of change in R.

(B) In the method (2) for calculating the UFR value shown in FIG. 4, one of the average pressure on the blood side and the average pressure on the dialysate side is measured as arterial pressure (PBi) or venous pressure (PBo). ) Or as the liquid supply system pressure (PDi) or the drainage system pressure (PDo), and substitute it into the formula according to the formula (3) to calculate the pressure gradient Δp, and based on the formula (4). T
The UFR value can be calculated by obtaining the MP value and substituting the TMP value and the ultrafiltration rate v into the equation (1). Even in this case, since the flow path specific resistance is different as in the above case, it is possible to monitor the change amount of the UFR intended by the present invention. In addition, the pressure gradient Δp or TM
As the P value, not only the arithmetic mean value but also the logarithmic mean value can be used.

Since the UFR value of the dialyzer is generally known in advance, for example, the upper and lower limit alarm levels of a predetermined range should be set for the UFR value obtained by the above calculation method (2). By this, an alarm can be generated when the detected UFR value exceeds the alarm level, and an appropriate operation is performed even when an abnormal UFR value is detected during dialysis treatment (especially immediately after the start). A control and monitoring system can be constructed.

[0046]

As is apparent from the above-described embodiments, according to the ultrafiltration control monitoring system of the dialysis apparatus according to the present invention, the outlet pressure or the inlet pressure is detected from the blood system connected to the blood side of the dialyzer. Then, the outlet pressure or the inlet pressure is detected from the dialysate side, and the ultrafiltration rate of the dialyzer membrane of the dialyzer, that is, the UFR value is calculated from these detected values at a preset time interval, and the ultrafiltration rate at a certain time point is calculated. Of the ultrafiltration rate before that time and comparing the comparison value with an alarm condition set in advance, by providing a calculation means, the limit value that changes with the passage of time Ultrafiltration control monitoring can be performed that is well matched to the ultrafiltration control characteristics.

In particular, in the present invention, changes in the ultrafiltration rate (UFR) over time due to clogging of the dialyzer membrane of the dialyzer, changes in plasma osmotic pressure over time, changes in blood flow rate and changes in ultrafiltration rate are observed. It is possible to effectively monitor the corresponding ultrafiltration control, improve the performance of this kind of dialysis device, and further improve the safety of the ultrafiltration control.

Although the preferred embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and various design changes can be made without departing from the spirit of the present invention. Of course. For example, in the above-described embodiment, as a dialysis device provided with an ultrafiltration control mechanism to which the ultrafiltration control monitoring system of the present invention is applied,
The case where an equal flow rate circuit is configured by using a double pump on the dialysate side of the dialyzer is shown, but the present invention is not limited to this example, and a conventionally known diaphragm chamber or a viscous chamber can be used. Alternatively, the ultrafiltration control of the present invention can be applied to a dialysis machine having an ultrafiltration control mechanism having an equal flow circuit by controlling the flow rate of pumps provided in the supply / drainage systems with an electromagnetic flowmeter. It is possible that a surveillance system can be applied.

[Brief description of drawings]

FIG. 1 shows monitoring contents as an embodiment of an ultrafiltration control monitoring system for a dialysis machine according to the present invention,
It is a characteristic diagram of the ultrafiltration rate with respect to dialysis time.

FIG. 2 is a general characteristic diagram of ultrafiltration rate with respect to dialysis time.

FIG. 3 is an explanatory diagram showing the monitoring conditions of the dialyzer in the ultrafiltration control monitoring system of the dialysis machine according to the present invention.

FIG. 4 is an explanatory diagram showing another configuration example of the monitoring conditions of the dialyzer in the ultrafiltration control monitoring system of the dialysis device according to the present invention.

FIG. 5 is a schematic system diagram showing a configuration example of a dialysis machine that implements the ultrafiltration control monitoring system according to the present invention.

FIG. 6 is a system diagram showing an outline of an ultrafiltration control monitoring system in a conventional dialysis machine.

FIG. 7 is a water removal control characteristic diagram of a dialyzer by an ultrafiltration control monitoring system in a conventional dialysis apparatus.

[Explanation of symbols]

10 dialyzer 12 double pump 14 dialysate supply system 16 dialysate drainage system 18a, 18b pump section 20 bypass pipe 22 pressurizing pump 24 degassing chamber 26 ultrafiltration pump 28 ultrafiltration system 30 degassing pipe 32 blood pump 34 blood system 36 dialysate pressure sensor 38 venous pressure sensor 40 venous pressure sensor 42 drainage system pressure sensor 44 arterial pressure sensor 46 supply system pressure sensor

Claims (8)

[Claims] 1. In a dialysis machine equipped with an ultrafiltration control mechanism, an ultrafiltration pressure (TM) against a dialysis membrane of a dialyzer.
Ultrafiltration rate (UFR) from P) and ultrafiltration rate (v)
Is calculated continuously, and the amount of change in the ultrafiltration rate at a certain point is compared with the amount of change in the ultrafiltration rate before that point, and an alarm is issued when the comparison value meets the preset alarm condition. An ultrafiltration control and monitoring system for a dialysis machine, characterized in that it is provided with a computing means for generating it. 2. The calculating means calculates the ultrafiltration rate (UFR) of the dialyzer, and the outlet pressure (PBo) on the blood side of the dialyzer.
And the outlet pressure (PDo) on the dialysate side, the ultrafiltration pressure (TMP) is calculated by the following formula 1, and the ultrafiltration pressure (TM) is calculated.
The ultrafiltration control monitoring system for a dialysis machine according to claim 1, which is calculated by the following equation 2 from P) and the ultrafiltration rate (v). [Equation 1] [Equation 2] 3. The calculating means calculates the ultrafiltration rate (UFR) of the dialyzer, and the inlet pressure (PBi) on the blood side of the dialyzer.
And the inlet pressure (PDi) on the dialysate side, the ultrafiltration pressure (TMP ') is calculated by the following equation 3, and the ultrafiltration pressure (TM) is calculated.
The ultrafiltration control monitoring system for a dialysis machine according to claim 1, which is calculated from the following equation 4 from P ′) and the ultrafiltration rate (v). [Equation 3] [Equation 4] 4. The calculating means calculates the ultrafiltration rate (UFR) of the dialyzer, and the outlet pressure (PBo) on the blood side of the dialyzer.
And the inlet pressure (PBi) and the outlet pressure (PDo) and the inlet pressure (PDi) on the dialysate side according to the following equation 5, the pressure gradient (Δ
p) is calculated, the ultrafiltration pressure (TMP) is obtained from the pressure gradient (Δp) by the following equation 6, and the ultrafiltration pressure (TM) is calculated.
The ultrafiltration control monitoring system for a dialysis machine according to claim 1, which is calculated by the following equation 7 from P) and the ultrafiltration rate (v). [Equation 5] [Equation 6] [Equation 7] 5. The calculation means calculates the change amount (ΔUFRt _n ) of the ultrafiltration rate of the dialyzer at a certain time point (t _n ) and the ultrafiltration rate at that time point and a predetermined time interval (Δt) before that. time (t _n -Δt ₁₎ ultrafiltration control monitoring system of the dialysis device as claimed in any one claims 1 becomes calculated as the difference 4 between the ultrafiltration rate. 6. The calculation means is configured to correct the disturbance α from the ultrafiltration pressure of the dialysis membrane of the dialyzer when the ultrafiltration rate is 0. Ultrafiltration control monitoring system for dialysis equipment. 7. A predetermined time interval (Δ
The ultrafiltration control monitoring system for a dialysis machine according to claim 5, wherein t) is set small after the start of dialysis and set large as the dialysis progresses. 8. The ultrafiltration control monitoring system for a dialysis machine according to claim 1, wherein the alarm condition in the computing means is set gently immediately after the start of dialysis and becomes strict as the dialysis progresses.