JPH06340539A - Docosahexaenoic acid pharmaceutical - Google Patents

Abstract

PURPOSE:To prepare the subject pharmaceutical excellent in efficacy compared to the case with single intake of docosahexaenoic acid(DHA) or ginkgo leaf extract. CONSTITUTION:This pharmaceutical can be obtained by adding a ginkgo extract to docosahexaenoic acid. In improving learning memory or geriatric dementia symptom, this pharmaceutical is more effective than the case with single intake of DHA or ginkgo leaf extract.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a DHA preparation containing docosahexaenoic acid (hereinafter referred to as "DHA").

[0002]

BACKGROUND OF THE INVENTION DHA is abundant in seafood, and in recent years, attention has been focused on the function of DHA for improving learning and memory ability and the preventive and recovery function for senile dementia. It is also said to have functions of suppressing cancer, lowering cholesterol, suppressing rheumatism and asthma. In addition, ginkgo biloba extract extracted from ginkgo biloba has the effects of dilating blood vessels to improve blood flow and improving blood circulation in the brain, and is effective in reducing motivation, memory, and senile dementia. is there. In Germany and France, medicines containing ginkgo biloba extract as a main ingredient have been approved as agents for improving brain and peripheral circulation. Furthermore,
Ginkgo biloba extract is said to have functions such as cancer control and asthma control. The DHA and Ginkgo biloba extract are provided individually as functional foods. Further, ginkgo biloba extract has been proposed in which it is mixed with chlorella, coffee or the like in order to reduce the peculiar bitterness and odor (JP-A-2-49544 and JP-A-5-7577).
issue).

[0003]

DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention
Ginkgo biloba extract has many overlapping parts in its function and utility, but it is presumed that the mechanism of its function and effect are different. However, in the prior art, each of the above-mentioned functions and effects is intended to obtain DHA and ginkgo biloba extract independently, and the synergistic effect of both is not taken into consideration. The present invention focuses on the closeness of the functions and effects of DHA and Ginkgo biloba extract, and seeks to obtain a formulation having a more excellent effect than in the case of ingesting each alone due to the synergistic effect of both.

[0004]

According to the present invention, a Ginkgo biloba leaf extract is added to DHA, and the amount of the Ginkgo biloba leaf extract varies depending on the amounts of flavonoids and ginkgolides contained therein. -20% by weight is suitable. The DHA is extracted by a known method. For example, oil is squeezed from fish meat, deoxidized, decolorized, concentrated, and then deodorized to obtain DHA oil and fat. This DHA fat has a DHA concentration of about 40% or more. Since DHA fats and oils are triglycerides of unstable fatty acids having many double bonds in the molecule, they are easily affected by oxygen, ultraviolet rays, and temperature, and are particularly likely to be oxidized by oxygen.

In the ginkgo biloba extract, improvement of cardiovascular diseases and suppression of cancer are centered on the action of flavonoids,
It has been announced that the suppression of asthma is centered on the action of ginkgolide. Although it is unclear whether the functions of both components are clearly understood in this way, it is generally recognized that the active ingredients in ginkgo biloba extract are flavonoids and ginkgolides. This invention is also considered to mainly utilize the action of these components in the ginkgo biloba extract. Therefore, the amount of Ginkgo biloba extract added to DHA varies depending on the contents of these components, flavonoids and ginkgolides in the Ginkgo biloba extract. Further, the amount of ginkgo biloba extract added varies depending on whether the intended medical effect of the preparation is obtained by the action of flavonoids or the action of ginkgolide.

The ginkgo biloba extract is extracted by a known method. For example, dried ginkgo biloba leaves are heated to reflux in ethanol to concentrate a solution, which is then extracted with an organic solvent. This ginkgo biloba extract was used in liquid form in the following examples, but it can also be used in powder form.
The flavonoid or ginkgolide, which is a component of the ginkgo biloba extract, may be obtained by synthesizing an organic substance.
The flavonoid or ginkgolide obtained by synthesis is also included in the concept of the ginkgo biloba extract of the present invention.

[0007]

EFFECTS OF THE INVENTION DHA is an essential element for increasing dendrites and synapses of brain cells, and ginkgo biloba extract is known to have a function of activating brain cells. Then, an increase in dendrites and synapses, and an increase in synapse binding rate lead to development of intelligence and improvement of learning function. Senile dementia includes cerebral vascular type caused by cerebrovascular disorder and Alzheimer's type in which nerve cells in the brain disappear over a wide area. The antithrombotic effect of DHA has a function of improving vascular disorder which is a cause of senile dementia of cerebrovascular type, and the function of activating brain cells to prevent and improve Alzheimer type senile dementia It is inferred to have. As shown in the following examples, according to the present invention, a higher effect was confirmed in improving learning and memory ability and preventing senile dementia as compared with administration of DHA alone. It is considered that this is because the interaction of DHA and Ginkgo biloba extract increased the synaptic binding rate by a factor of 2 to 5, resulting in activation of cells.

[0008]

Example A liquid ginkgo biloba extract was added to 300 mg of DHA at the ratio shown in Table 1 to prepare a formulation. As a product to be administered to humans, the above-mentioned preparation is soft-encapsulated. The soft encapsulation is performed in a nitrogen atmosphere without heating in order to prevent heat-induced denaturation of DHA and oxidation due to contact with air. The amounts shown in Table 1 are based on the assumption that an adult will take 2 capsules 3 times a day.

[Table 1]

1. Learning function After learning that rats are fed food when the lever is pressed when the lights are on, they are divided into 5 groups (10 animals in each group), and each group is ingested each formulation of Table 1 to improve the learning effect. It was measured. Table 2 shows the percentage of correct answers on the 15th day after the start of the test.

[Table 2] From this test result, it was confirmed that addition of Ginkgo biloba extract to DHA resulted in higher learning function improvement than administration of DHA or Ginkgo biloba extract alone.

2. Senile dementia Fifty subjects with senile dementia were divided into 5 groups (10 in each group), and the formulation of Table 1 was administered 3 times a day at 2 capsules for 2 months for evaluation. As evaluation criteria, 14 items of activity, insight, headache symptom, dizziness symptom, spatial recognition, time recognition, mobility, putting on and taking off clothes, eating, excretion, sleep, daytime somnolence, anxiety, and feeling of tragedy, respectively, Evaluation was made on a scale of 5 points, and the total point was used to evaluate the degree of dementia. The results are shown in Table 3.

[Table 3] From this test result, it was confirmed that the addition effect of Ginkgo biloba extract to DHA was more effective in improving dementia than administration of DHA or Ginkgo biloba extract alone.

Claims (3)

[Claims] 1. A docosahexaenoic acid preparation prepared by adding ginkgo biloba extract to docosahexaenoic acid. 2. The docosahexaenoic acid preparation according to claim 1, wherein the amount of the ginkgo biloba extract is 3 to 20% by weight of docosahexaenoic acid. 3. A functional food comprising the docosahexaenoic acid preparation according to claim 1 or 2.