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JPH06504449A - 合成アルファ−ｌ−イズロニダーゼおよびそれをコード化する遺伝子配列 - Google Patents

合成アルファ−ｌ−イズロニダーゼおよびそれをコード化する遺伝子配列

Info

Publication number
JPH06504449A
JPH06504449A JP5508825A JP50882593A JPH06504449A JP H06504449 A JPH06504449 A JP H06504449A JP 5508825 A JP5508825 A JP 5508825A JP 50882593 A JP50882593 A JP 50882593A JP H06504449 A JPH06504449 A JP H06504449A
Authority
JP
Japan
Prior art keywords
idua
mammalian
molecule
nucleic acid
isolated nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5508825A
Other languages
English (en)
Japanese (ja)
Inventor
スコット，ハミッシュ・スティール
アンソン，ドナルド・スチュアート
オースボーン、アネット・マリー
ネルソン，ポール・ビクター
クレメンツ，ピーター・ロイ
モーリス、チャールズ・フィリップ
ホップウッド，ジョン・ジョセフ
Original Assignee
ウイミンズ・アンド・チルドレンズ・ホスピタル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウイミンズ・アンド・チルドレンズ・ホスピタル filed Critical ウイミンズ・アンド・チルドレンズ・ホスピタル
Publication of JPH06504449A publication Critical patent/JPH06504449A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01076—L-Iduronidase (3.2.1.76)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5508825A 1991-11-14 1992-11-12 合成アルファ−ｌ−イズロニダーゼおよびそれをコード化する遺伝子配列 Pending JPH06504449A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU9490 1986-12-12
AUPK949091 1991-11-14
PCT/AU1992/000611 WO1993010244A1 (fr) 1991-11-14 1992-11-12 α-L IDURONIDASE SYNTHETIQUE ET SEQUENCES GENETIQUES LA CODANT

Publications (1)

Publication Number Publication Date
JPH06504449A true JPH06504449A (ja) 1994-05-26

Family

ID=3775823

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5508825A Pending JPH06504449A (ja) 1991-11-14 1992-11-12 合成アルファ−ｌ−イズロニダーゼおよびそれをコード化する遺伝子配列

Country Status (7)

Country Link
EP (1) EP0578790A4 (fr)
JP (1) JPH06504449A (fr)
KR (1) KR930703447A (fr)
AU (1) AU649897B2 (fr)
CA (1) CA2099503C (fr)
NZ (1) NZ245123A (fr)
WO (1) WO1993010244A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058691A2 (fr) * 1998-05-13 1999-11-18 Harbor-Ucla (alpha)-l-iduronidase recombinee, procedes de production et de purification de celle-ci et methodes de traitement de maladies dues a des deficits en celle-ci
US6569661B1 (en) 1999-11-12 2003-05-27 Biomarin Pharmaceutical Inc. Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6426208B1 (en) 1999-11-12 2002-07-30 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
GB0606190D0 (en) 2006-03-28 2006-05-10 Isis Innovation Construct
US8679478B2 (en) 2010-10-04 2014-03-25 Duke University Methods of lysosomal storage disease therapy
EP2630241B1 (fr) * 2010-10-22 2018-10-17 CuRNA, Inc. Traitement de maladies associées à l'alpha-l-iduronidase (idua) par inhibition du transcrit antisens endogène de idua
WO2017049157A1 (fr) 2015-09-18 2017-03-23 Duke University Méthodes et compositions pour le traitement de troubles associés à une stéatose
UY37587A (es) * 2017-01-31 2018-08-31 Regenxbio Inc Tratamiento de mucopolisacaridosis i con alfa-l-iduronidasa (idua) humana glicosilada completamente humana
EP3676385A1 (fr) 2017-07-06 2020-07-08 The Trustees of The University of Pennsylvania Thérapie génique médiée par aav9 pour traiter la mucopolysaccharidose de type i
WO2019060662A1 (fr) 2017-09-22 2019-03-28 The Trustees Of The University Of Pennsylvania Thérapie génique pour le traitement de la mucopolysaccharidose de type ii

Also Published As

Publication number Publication date
KR930703447A (ko) 1993-11-30
WO1993010244A1 (fr) 1993-05-27
NZ245123A (en) 1995-05-26
CA2099503C (fr) 2007-10-09
AU649897B2 (en) 1994-06-02
AU2914192A (en) 1993-06-15
EP0578790A1 (fr) 1994-01-19
CA2099503A1 (fr) 1993-05-15
EP0578790A4 (fr) 1994-11-02

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Legal Events

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A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060711

A602 Written permission of extension of time

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Effective date: 20060714