JPH07111985A - Capsule apparatus for medical treatment - Google Patents
Capsule apparatus for medical treatmentInfo
- Publication number
- JPH07111985A JPH07111985A JP5259882A JP25988293A JPH07111985A JP H07111985 A JPH07111985 A JP H07111985A JP 5259882 A JP5259882 A JP 5259882A JP 25988293 A JP25988293 A JP 25988293A JP H07111985 A JPH07111985 A JP H07111985A
- Authority
- JP
- Japan
- Prior art keywords
- capsule
- bellows
- capsules
- body cavity
- ultrasonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 130
- 238000004891 communication Methods 0.000 claims abstract description 25
- 238000012790 confirmation Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 description 16
- 239000012530 fluid Substances 0.000 description 15
- 239000003814 drug Substances 0.000 description 14
- 229940079593 drug Drugs 0.000 description 14
- 210000000936 intestine Anatomy 0.000 description 13
- 239000007789 gas Substances 0.000 description 12
- 238000004090 dissolution Methods 0.000 description 10
- 230000000968 intestinal effect Effects 0.000 description 10
- 230000001079 digestive effect Effects 0.000 description 9
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 8
- 210000004051 gastric juice Anatomy 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 241000167880 Hirundinidae Species 0.000 description 5
- 230000001133 acceleration Effects 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000008151 electrolyte solution Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000002594 fluoroscopy Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 2
- 230000005389 magnetism Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Endoscopes (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】この発明は体腔内の部位を直接的
に観察し、診断や治療を行う医療用カプセル装置に関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical capsule device for directly observing a site inside a body cavity for diagnosis and treatment.
【０００２】[0002]
【従来の技術】医療用カプセル装置は、患者の口腔から
体腔内に挿入する内視鏡とは異なり、患者が飲み込むこ
とにより、体外装置と無線的に接続されているため、患
者に与える苦痛を大きく軽減できることで注目されてい
る。2. Description of the Related Art Unlike an endoscope which is inserted from a patient's oral cavity into a body cavity, a medical capsule device is wirelessly connected to an extracorporeal device when swallowed by a patient, so that it causes pain to the patient. It is attracting attention because it can be greatly reduced.
【０００３】従来、例えば、特開昭５７−１５６７３６
号公報に示すように、医療用カプセル装置は、薬液を投
与したり、体液、組織を採取する機能を持っており、体
腔内において薬液を投与し、また体液、組織を採取する
ことができるようになっている。Conventionally, for example, JP-A-57-156736.
As shown in the publication, the medical capsule device has a function of administering a medicinal solution and collecting body fluid and tissue, so that it can administer the medicinal solution in the body cavity and also collect body fluid and tissue. It has become.
【０００４】また、最近では、特願平４−２２４１８０
号に示すように、前述した機能に加えてカプセル本体に
マニピュレータを設け、患部等を積極的に処置すること
ができるものも提案されている。Recently, Japanese Patent Application No. 4-224180
In addition to the above-mentioned functions, there is also proposed a capsule manipulator that can positively treat an affected area or the like, as shown in No.
【０００５】ところで、医療用カプセル装置は、体腔内
のどの位置にあるかを知ることは、薬液を投与したり、
体液、組織を採取する上において重要なことであるが、
従来の医療用カプセル装置は、図１２に示すように、体
腔内、例えば管腔ａ内をカプセルｂが転動しながら下降
（進行）していくため、カプセルｂ自身がある特定時間
にどの方向を向いているのか判断できない。By the way, it is necessary to know the position of the medical capsule device in the body cavity by administering a medicinal solution,
It is important for collecting body fluids and tissues,
In the conventional medical capsule device, as shown in FIG. 12, the capsule b descends (advances) while rolling inside the body cavity, for example, the lumen a. I can't tell if I'm facing.
【０００６】また、例えば米国特許第５，１７０，８０
１号明細書で示すように、Ｘ線やＭＲＩ等の透視診断装
置で位置確認を行うか、カプセル自身の発する磁気等の
エネルギを体外から捕捉するという手段が用いられてい
る。Also, for example, US Pat. No. 5,170,80
As shown in the specification of No. 1, means for confirming the position by a fluoroscopic diagnosis apparatus such as X-ray or MRI or capturing energy such as magnetism generated by the capsule itself from outside the body is used.
【０００７】[0007]
【発明が解決しようとする課題】しかしながら、従来の
医療用カプセル装置において、カプセルの体腔内の位置
を確認するために、Ｘ線による透視を行うことはＸ線被
爆の問題があり、頻繁に位置確認を行うことはできな
い。However, in the conventional medical capsule device, performing X-ray fluoroscopy to confirm the position of the capsule in the body cavity has a problem of X-ray exposure, and the position is frequently changed. No confirmation can be made.
【０００８】また、ＭＲＩによる透視では強力磁場を使
用するために医療用カプセル装置に、鉄系金属などの磁
性体材料は用いることができない。また、ＭＲＩ装置が
大型であるため、手軽に行うことはできない。さらに、
カプセル自身の発するエネルギを体外で捕捉する方式で
は１点の位置情報しか得られないために時間的に位置を
追った時に、これからの動きの予測を正確に行うことは
難しいという事情がある。Further, magnetic field materials such as iron-based metals cannot be used in medical capsule devices because a strong magnetic field is used in MRI fluoroscopy. Moreover, since the MRI apparatus is large, it cannot be performed easily. further,
In the method of capturing the energy generated by the capsule itself outside the body, only position information of one point can be obtained, so that it is difficult to accurately predict future movement when tracking the position temporally.
【０００９】すなわち、従来のカプセルの経路算出方法
は、図１３に示すように、ｔ1,ｔ2…ｔ5 時間でのそれ
ぞれのカプセルの位置１点を測定することによってｔ6
時間でのカプセルの位置および速度を数学的に算出する
場合、多項式近似によって行う。That is, according to the conventional capsule route calculation method, as shown in FIG. 13, t 6 is obtained by measuring one point of each capsule at time t 1, t 2 ... T 5
When mathematically calculating the position and velocity of the capsule in time, it is done by polynomial approximation.
【００１０】[0010]
【数１】 [Equation 1]
【００１１】すなわち、ｔ1 〜ｔ5 の位置データを用い
て４次の近似多項式による算出が可能であるが、カプセ
ルの位置を正確に把握することができない。この発明
は、前記事情に着目してなされたもので、その目的とす
るところは、体腔内のおけるカプセルの位置確認を手軽
に正確に行うことができると共に、カプセルの動きを高
い精度で予測することができる医療用カプセル装置を提
供することにある。That is, although it is possible to calculate by a fourth-order approximation polynomial using the position data of t 1 to t 5 , it is impossible to accurately grasp the position of the capsule. The present invention has been made in view of the above circumstances, and its purpose is to easily and accurately confirm the position of a capsule in a body cavity and to predict the movement of the capsule with high accuracy. An object is to provide a medical capsule device that can be used.
【００１２】[0012]
【課題を解決するための手段】この発明は前記目的を達
成するために、複数個のカプセルと、複数個のカプセル
を結合する弾性的な結合手段と、複数個のカプセルの互
いの位置関係を検知する位置検知手段と、検知した相対
的な位置関係情報を体外受信手段へ送信する通信手段と
を具備したことにある。In order to achieve the above object, the present invention provides a plurality of capsules, an elastic coupling means for coupling the plurality of capsules, and a positional relationship between the plurality of capsules. It is provided with a position detecting means for detecting and a communication means for transmitting the detected relative positional relationship information to the external receiving means.
【００１３】[0013]
【作用】複数のカプセルが弾性的な結合手段によって結
合され、この結合手段に歪ゲージ等の位置検知手段を設
けることにより、カプセルのそれぞれの位置を確認する
ことができ、よって次の位置測定時のカプセルの位置、
複数個のカプセルの相対的位置関係を数学的近似によっ
て精度良く予測することができる。The plurality of capsules are joined by the elastic joining means, and by providing the joining means with the position detecting means such as the strain gauge, the respective positions of the capsules can be confirmed. Therefore, at the time of the next position measurement. The position of the capsule,
The relative positional relationship of a plurality of capsules can be accurately predicted by mathematical approximation.
【００１４】[0014]
【実施例】以下、この発明の各実施例を図面に基づいて
説明する。図１〜図３は第１の実施例を示し、図１は医
療用カプセル装置の全体図を示す。医療用カプセル装置
は、第１のカプセル１と第２のカプセル２および両カプ
セル１，２を弾性的に結合する結合手段としての結合部
材３とから構成されている。Embodiments of the present invention will be described below with reference to the drawings. 1 to 3 show a first embodiment, and FIG. 1 shows an overall view of a medical capsule device. The medical capsule device is composed of a first capsule 1, a second capsule 2 and a coupling member 3 as a coupling means for elastically coupling the capsules 1 and 2.
【００１５】第１のカプセル１は、略球状で、その前部
には前方を観察するための観察手段としての観察光学系
４および生体組織の把持、切開、切除を行うためのマニ
ピュレータ５が設けられている。さらに、第１のカプセ
ル１の後部には生体内の温度、PＨを測定するセンサ６
が設けられている。第２のカプセル２も略球状で、内部
には体外通信手段（図示しない）と交信するための通信
手段７が設けられている。The first capsule 1 has a substantially spherical shape, and an observation optical system 4 as an observation means for observing the front and a manipulator 5 for grasping, incising, and excising a living tissue are provided in the front part of the first capsule 1. Has been. Further, a sensor 6 for measuring in-vivo temperature and PH is provided on the rear part of the first capsule 1.
Is provided. The second capsule 2 is also substantially spherical, and has a communication means 7 for communicating with an extracorporeal communication means (not shown) inside.
【００１６】前記結合部材３は、弾性を有する合成樹脂
材料等からなる棒状体で、その中間部には位置検知手段
としての歪ゲージ８が取付けられ、結合部材３が屈曲さ
れたときの弾性歪を検知することにより、第１と第２の
カプセル１，２の相対的位置関係を知ることができるよ
うになっている。The connecting member 3 is a rod-shaped body made of an elastic synthetic resin material or the like, and a strain gauge 8 as a position detecting means is attached to an intermediate portion of the connecting member 3 to elastically deform the connecting member 3 when it is bent. The relative positional relationship between the first and second capsules 1 and 2 can be known by detecting the.
【００１７】したがって、前述のように構成された医療
用カプセル装置を口腔から飲み込むことにより、体腔
内、例えば管腔９を図１に示すように、第１のカプセル
１が前部に、第２のカプセル２が後部になって管腔９内
を進行する。この進行途中で、観察光学系４による観察
像、センサ６による温度、PＨの測定データおよび歪ゲ
ージ８による歪情報は、通信手段７によって体外通信手
段へ送信される。また、体外通信手段から送信された信
号を通信手段７によって受信し、この信号に従ってマニ
ピュレータ５を動作させることができ、生体組織の把
持、切開、切除等を行うことができる。Therefore, by swallowing the medical capsule device configured as described above from the oral cavity, the first capsule 1 is placed in the front part, and the second capsule is placed in the body cavity, for example, the lumen 9, as shown in FIG. The capsule 2 becomes the rear part and advances inside the lumen 9. During this process, the observation image by the observation optical system 4, the temperature by the sensor 6, the measurement data of PH and the strain information by the strain gauge 8 are transmitted to the extracorporeal communication unit by the communication unit 7. Moreover, the signal transmitted from the extracorporeal communication means can be received by the communication means 7, and the manipulator 5 can be operated in accordance with this signal, and the living tissue can be grasped, incised, excised, and the like.
【００１８】次に、医療用カプセル装置の作用について
説明する。図２に示すように、第１のカプセル１、第２
のカプセル２の順に口腔から飲み込むことにより、第１
のカプセル１が前部に、第２のカプセル２が後部になっ
て管腔９内を進行する。このとき、第１のカプセル１と
第２のカプセル２が結合部材３によって連結されている
ため、自由な回転は、第１、第２カプセル１，２を結ぶ
カプセル中心軸の軸線回り（矢印）だけであり、常に管
腔９の中心軸とカプセル中心軸は概ね一致しており、第
１のカプセル１の前部は常に進行方向に向いている。Next, the operation of the medical capsule device will be described. As shown in FIG. 2, the first capsule 1 and the second capsule
By swallowing the capsules 2 in order from the oral cavity,
The capsule 1 is in the front part and the second capsule 2 is in the rear part and advances inside the lumen 9. At this time, since the first capsule 1 and the second capsule 2 are connected by the connecting member 3, the free rotation is about the axis of the capsule central axis connecting the first and second capsules 1 and 2 (arrow). However, the central axis of the lumen 9 and the central axis of the capsule are almost always aligned with each other, and the front part of the first capsule 1 is always oriented in the traveling direction.
【００１９】次に、カプセルの経路の算出について図３
に基づき説明する。結合部材３には歪ゲージ８が設けら
れているため、歪ゲージ８によって第１と第２のカプセ
ル１，２の相対位置関係が測定できるため、１日の測定
ｔｎ時間に２点のカプセル位置を求めることができる。
したがって、ｔ1 〜ｔ5 時間での位置情報を基に多項式
の係数ベクトルを求める式は１０本作ることが可能であ
り、このため９次の多項式の係数ベクトルを算出でき
る。したがって、従来のカプセルよりも同じ時間計測に
よって、より高次の精度の多項式により次時間のカプセ
ルの位置を高い精度で予測することができる。Next, the calculation of the capsule path will be described with reference to FIG.
It will be explained based on. Since the strain gauge 8 is provided on the coupling member 3, the relative position relationship between the first and second capsules 1 and 2 can be measured by the strain gauge 8, so that two capsule positions can be measured during the measurement tn time of one day. Can be asked.
Thus, the formula for determining the coefficient vector of the polynomial based on the position information at t 1 ~t 5 hours was able to make ten, can be calculated coefficient vector of this for 9-order polynomial. Therefore, it is possible to predict the position of the capsule at the next time with high accuracy by using the polynomial with higher accuracy by the same time measurement as that of the conventional capsule.
【００２０】この結果、診断、治療をより正確に行うこ
とができる。また、カプセルの前部が常に管腔の前方を
向いているために観察像のオリエンテーションがつけ易
く、また所望の箇所でのアンビュレーションを容易に行
うことができる。As a result, diagnosis and treatment can be performed more accurately. Further, since the front part of the capsule always faces the front of the lumen, it is easy to orient the observation image, and it is possible to easily carry out ambition at a desired position.
【００２１】図４〜図６は第２の実施例を示し、図４は
腸１０内を医療用カプセル装置が進行している状態を示
し、図５は、第１の実施例における第１、第２のカプセ
ル１，２の一方の内部構造を示し、以下、単にカプセル
１１という。このカプセル１１の内部における一側部に
は液体を収容した室に超音波振動子１２が設けられ、こ
の超音波振動子１２はラジアル走査を行う超音波モータ
１３によって支持されている。さらにカプセル１１の内
部における中央部には超音波の送受波を行うための送受
波回路１４、超音波画像信号を体外に伝送する送信回路
１５が設けられ、カプセル１１の内部における他側部に
はカプセル駆動用の電池１６が設けられている。4 to 6 show a second embodiment, FIG. 4 shows a state in which the medical capsule device is advancing in the intestine 10, and FIG. 5 shows the first and second embodiments. The internal structure of one of the second capsules 1 and 2 is shown, and is simply referred to as the capsule 11 hereinafter. An ultrasonic vibrator 12 is provided in a chamber containing a liquid on one side inside the capsule 11, and the ultrasonic vibrator 12 is supported by an ultrasonic motor 13 that performs radial scanning. Further, a transmission / reception circuit 14 for transmitting / receiving ultrasonic waves and a transmission circuit 15 for transmitting an ultrasonic image signal to the outside of the body are provided in the central portion inside the capsule 11, and the other side portion inside the capsule 11 is provided. A battery 16 for driving the capsule is provided.
【００２２】カプセル１１は消化管腔の蠕動により体腔
内を進行し、逐次体腔内の超音波断層像を体外に送信す
る。体外では図６に示す、体外通信手段としての体外受
信装置１７によりカプセル１１からの信号を受信して超
音波画像を表示する。体外受信装置１７は超音波信号を
受信するアンテナ１８、受信回路１９、受信信号を断層
像に変換する超音波画像生成回路２０、得られた超音波
断層像を３次元画像に構築する３次元超音波画像構築回
路２１および画像表示ディスプレイ２２からなり、体腔
内より伝送されてくる超音波断層像を３次元画像に構築
して表示する。The capsule 11 advances in the body cavity by the peristalsis of the digestive tract cavity, and successively transmits ultrasonic tomographic images of the body cavity outside the body. Outside the body, an extracorporeal receiving device 17 as an extracorporeal communication unit shown in FIG. 6 receives a signal from the capsule 11 and displays an ultrasonic image. The extracorporeal receiving device 17 includes an antenna 18 for receiving an ultrasonic signal, a receiving circuit 19, an ultrasonic image generating circuit 20 for converting the received signal into a tomographic image, and a three-dimensional super image for constructing the obtained ultrasonic tomographic image into a three-dimensional image. It is composed of a sound wave image construction circuit 21 and an image display 22 and constructs and displays an ultrasonic tomographic image transmitted from inside the body cavity into a three-dimensional image.
【００２３】このようにカプセル１１から伝送される体
腔内の超音波断層信号を体外にて３次元超音波画像に構
築、表示することにより、超音波プローブ、内視鏡等で
は到達し得ない体深部（小腸等）も含め、消化管すべて
に亘って３次元断層像が得られ、生理学的研究の有用な
データ獲得や病変の診断を行うことができる。As described above, by constructing and displaying the ultrasonic tomographic signal in the body cavity transmitted from the capsule 11 on the outside of the body in a three-dimensional ultrasonic image, the body which cannot be reached by the ultrasonic probe, the endoscope or the like. Three-dimensional tomographic images can be obtained over the entire digestive tract, including the deep part (small intestine, etc.), and useful data acquisition for physiological research and diagnosis of lesions can be performed.
【００２４】図７は第３の実施例を示し、カプセル１１
と体外受信装置１７のブロック図であり、カプセル１１
には第２の実施例に加えて例えば圧電素子で構成されて
いる加速度センサ２３が内蔵されている。この加速度セ
ンサ２３の検出信号は送信回路１４に入力され、超音波
受波信号とともに時分割多重もしくは周波数多重され、
体外に送信される。FIG. 7 shows a third embodiment of the capsule 11
2 is a block diagram of the extracorporeal receiving device 17, and FIG.
In addition to the second embodiment, a built-in acceleration sensor 23, which is composed of a piezoelectric element, is built in. The detection signal of the acceleration sensor 23 is input to the transmission circuit 14 and time-division multiplexed or frequency-multiplexed with the ultrasonic wave reception signal,
Sent outside the body.
【００２５】体外受信装置１７では受信回路にて超音波
受波信号と加速度信号を分離する。加速度信号は位置・
速度検出回路２４に入力され、カプセル１１の位置・速
度を検出する。速度データは３次元超音波画像構築回路
２１に入力され、カプセル１１の速度変化に対応して３
次元画像構築を行うことにより正確で見易い３次元画像
が得られる。また、位置データによりＸ線等を使用せず
に体腔内でのカプセル１１の位置を知ることができる。In the extracorporeal receiving device 17, the receiving circuit separates the ultrasonic wave reception signal and the acceleration signal. Acceleration signal is position
It is input to the speed detection circuit 24 and detects the position and speed of the capsule 11. The velocity data is input to the three-dimensional ultrasonic image constructing circuit 21, and the velocity data of the capsule 11 is changed to 3
An accurate and easy-to-see three-dimensional image can be obtained by performing the three-dimensional image construction. Further, the position data enables the position of the capsule 11 in the body cavity to be known without using X-rays or the like.
【００２６】このように、カプセル１１に加速度センサ
２３を設けたことにより、カプセル１１の速度データに
よって３次元超音波画像構築の補正を行い、カプセル１
１の速度変化があった場合でも正確で見易い画像を得る
ことができる。また、位置データにより体腔内のカプセ
ル１１の位置を簡易に得ることができる。As described above, by providing the acceleration sensor 23 in the capsule 11, the three-dimensional ultrasonic image construction is corrected by the velocity data of the capsule 11, and the capsule 1
Even if there is a speed change of 1, an accurate and easy-to-see image can be obtained. Further, the position of the capsule 11 in the body cavity can be easily obtained from the position data.
【００２７】図８（ａ）（ｂ）は第４の実施例を示し、
第１の実施例における第１、第２のカプセル１，２の一
方の内部構造を示し、以下、単にカプセル３１という。
図８（ａ）に示すように、カプセル３１を構成する容器
３２内には伸縮性のバルーン３３と通常は収縮状態にあ
るベローズ３４が設けられている。バルーン３３の内部
には目的とする消化管内の患部で放出させる薬剤３５が
充填され、リザーバとしての役割を果たしている。FIGS. 8A and 8B show a fourth embodiment,
The internal structure of one of the first and second capsules 1 and 2 in the first embodiment is shown, and is simply referred to as capsule 31 hereinafter.
As shown in FIG. 8A, an elastic balloon 33 and a bellows 34 that is normally in a contracted state are provided in a container 32 that constitutes the capsule 31. The inside of the balloon 33 is filled with a drug 35 to be released at the target affected part in the digestive tract, and serves as a reservoir.
【００２８】バルーン３３の一端は容器３２の連通孔３
６と接続され、内外を連通している。一方、ベローズ３
４の一端も容器３２の連通孔３７と接続され、連通孔３
７には消化管内の消化液で選択的に溶解する溶解膜３８
が設けられている。また、連通孔３７にはカプセル３１
の外部からベローズ３４内のみに溶液が浸入してくるよ
うに逆止弁３９が設けられている。また、ベローズ３４
の内腔には消化管内の消化液と科学反応を起こして気体
（ガス）を発生する化学物質４０が充填されている。One end of the balloon 33 is connected to the communication hole 3 of the container 32.
6 is connected to communicate the inside and outside. Meanwhile, bellows 3
One end of 4 is also connected to the communication hole 37 of the container 32, and the communication hole 3
7 is a dissolution film 38 that selectively dissolves in the digestive juice in the digestive tract
Is provided. In addition, the communication hole 37 has a capsule 31.
A check valve 39 is provided so that the solution enters only into the bellows 34 from the outside. Also, the bellows 34
A chemical substance 40 that generates a gas by causing a chemical reaction with the digestive juice in the digestive tract is filled in the lumen of the.
【００２９】このように構成されたカプセル３１を胃内
で選択的に薬剤を放出する場合について説明すると、前
記溶解膜３８を胃液で消化されるゼラチン等で構成し、
またベローズ３４の内腔に設ける化学物質４０を胃液
（酸）と反応してガスを発生する物質とする。前記化学
物質４０としては、Ｋ，Ｃａ，Ｎａ，Ｍｇ，Ａｌ，Ｚｎ
等の金属あるいはＣａＣＯ3 等が用いられる。Explaining the case of selectively releasing the drug in the stomach of the capsule 31 thus constructed, the dissolution film 38 is made of gelatin or the like digested by gastric juice,
Further, the chemical substance 40 provided in the inner cavity of the bellows 34 is a substance that reacts with gastric juice (acid) to generate gas. As the chemical substance 40, K, Ca, Na, Mg, Al, Zn
A metal such as CaCO 3 or the like is used.
【００３０】患者がカプセル３１を飲み込むと、胃液等
の消化液４１で溶解膜３８が溶解し、図８（ｂ）に示す
ように、胃液が逆止弁３９を介してベローズ３４の内腔
に浸入する。そして、カプセル３１内の化学物質４０と
化学反応を起こし、水素ガス、二酸化炭素ガス等のガス
４２が発生する。ガス４２の発生に伴いベローズ３４は
伸張し、バルーン３３を押圧するため、バルーン３３の
内腔に充填された薬剤３５は連通孔３６を介して胃内に
放出される。When the patient swallows the capsule 31, the dissolution film 38 is dissolved by the digestive fluid 41 such as gastric juice, so that the gastric juice enters the inner cavity of the bellows 34 through the check valve 39 as shown in FIG. 8B. Infiltrate. Then, a chemical reaction occurs with the chemical substance 40 in the capsule 31, and a gas 42 such as hydrogen gas or carbon dioxide gas is generated. As the gas 42 is generated, the bellows 34 expands and presses the balloon 33, so that the drug 35 with which the inner cavity of the balloon 33 is filled is released into the stomach through the communication hole 36.
【００３１】一方、腸内で薬剤放出をさせる場合は、溶
解膜３８を腸液で消化される脂肪酸膜とする。また、ベ
ローズ３４の内腔の化学物質４０を腸液と化学反応を起
こしてガスを発生するＡｌ，Ｚｎ，Ｓｉ，ＮＨ4 Ｃｌ等
とする。On the other hand, when the drug is released in the intestine, the dissolution film 38 is a fatty acid film that is digested by intestinal fluid. Further, the chemical substance 40 in the inner cavity of the bellows 34 is Al, Zn, Si, NH 4 Cl or the like which generates a gas by chemically reacting with intestinal fluid.
【００３２】そして、患者がカプセル３１を飲み込み、
カプセル３１が腸内に到達すると、腸液により脂肪酸膜
からなる溶解膜３８が溶解する。そして、腸液が逆止弁
３９を介してベローズ３４の内腔に浸入する。そして、
カプセル３１内の化学物質４０と化学反応を起こし、水
素ガス、アンモニアガス等のガス４２が発生し、ベロー
ズ３４は伸張し、バルーン３３を押圧するため、バルー
ン３３の内腔に充填された薬剤３５は連通孔３６を介し
て腸内に放出される。Then, the patient swallows the capsule 31,
When the capsule 31 reaches the intestine, the intestinal fluid dissolves the dissolution film 38 made of a fatty acid film. Then, the intestinal fluid enters the inner cavity of the bellows 34 via the check valve 39. And
A chemical reaction with the chemical substance 40 in the capsule 31 generates a gas 42 such as hydrogen gas or ammonia gas, the bellows 34 expands and presses the balloon 33, so that the drug 35 filled in the inner cavity of the balloon 33 is generated. Is released into the intestine through the communication hole 36.
【００３３】このように構成したカプセルは、ベローズ
内腔に消化液（胃液、腸液）と反応してガスを発生する
化学物質を設けたため、従来のＸ線造影装置でカプセル
の位置を検出する必要はなく、また体外に大掛かりな超
音波や磁気発生手段を設ける必要もなく、体腔内の目的
とする患部で選択的に薬剤を放出させることができる。In the capsule thus constructed, a chemical substance that reacts with digestive fluid (gastric fluid, intestinal fluid) to generate gas is provided in the inner space of the bellows. Therefore, it is necessary to detect the position of the capsule with a conventional X-ray imaging apparatus. In addition, it is not necessary to provide a large-scale ultrasonic wave or magnetism generating means outside the body, and the drug can be selectively released at the target affected area inside the body cavity.
【００３４】図９（ａ）（ｂ）は第５の実施例を示し、
第４の実施例と同一構成部分については同一番号を付し
て説明を省略する。図９（ａ）に示すように、カプセル
４３の容器４４の側面には凹部４５が設けられ、この凹
部４５は連通孔４６を介して容器４４の内外を連通して
いる。凹部４５には消化液で溶解する溶解膜３８が取付
けられている。ベローズ３４の内腔にはガスを吸着した
吸着剤４７が設けられている。この吸着剤４７として
は、例えばＶ，Ｍｎ，Ｃｒ，Ｃｏ等が用いられる。ま
た、容器４４内のベローズ３４の周囲は消化液と化学反
応を起こして発熱する化学物質４８が設けられている。FIGS. 9A and 9B show a fifth embodiment,
The same components as those in the fourth embodiment are designated by the same reference numerals and the description thereof will be omitted. As shown in FIG. 9A, a concave portion 45 is provided on the side surface of the container 44 of the capsule 43, and the concave portion 45 communicates the inside and outside of the container 44 via a communication hole 46. A dissolution film 38 that dissolves in the digestive fluid is attached to the recess 45. An adsorbent 47 that adsorbs gas is provided in the inner cavity of the bellows 34. As the adsorbent 47, for example, V, Mn, Cr, Co or the like is used. Around the bellows 34 in the container 44, a chemical substance 48 that causes a chemical reaction with the digestive fluid to generate heat is provided.
【００３５】このように構成したカプセル４３を胃内で
選択的に薬剤を放出する場合について説明すると、前記
溶解膜３８を胃液で消化されるゼラチン等で構成し、ま
たベローズ３４の周囲の化学物質４８を胃液（酸）と反
応して発熱するアルカリ、ＮａＯＨ等とする。The case of selectively releasing a drug in the stomach of the capsule 43 thus constructed will be described. The dissolution film 38 is made of gelatin or the like digested by gastric juice, and the chemical substance around the bellows 34 is used. 48 is alkali, NaOH, etc. which generate heat by reacting with gastric juice (acid).
【００３６】患者がカプセル４３を飲み込むと、胃液等
の消化液４１で溶解膜３８が溶解し、図９（ｂ）に示す
ように、連通孔４６を介して胃液が容器４４内に浸入す
る。そして、消化液４１とベローズ３４の周囲に設けら
れた化学物質４８とが化学反応を起こして発熱する。こ
の発熱により吸着剤４７に吸着されていたガス４９が解
離放出され、ベローズ３４は伸張し、バルーン３３を押
圧するため、バルーン３３の内腔に充填された薬剤３５
は連通孔３６を介して胃内に放出される。When the patient swallows the capsule 43, the dissolution film 38 is dissolved by the digestive juice 41 such as gastric juice, and the gastric juice enters the container 44 through the communication hole 46, as shown in FIG. 9B. Then, the digestive fluid 41 and the chemical substance 48 provided around the bellows 34 cause a chemical reaction to generate heat. Due to this heat generation, the gas 49 adsorbed by the adsorbent 47 is dissociated and released, and the bellows 34 expands and presses the balloon 33, so that the drug 35 filled in the inner cavity of the balloon 33.
Is released into the stomach through the communication hole 36.
【００３７】一方、腸内で薬剤放出をさせる場合は、溶
解膜３８を腸液で消化される脂肪酸膜とし、ベローズ３
４の周囲に設ける化学物質４８を腸液と化学反応を起こ
して発熱するＨＣｌ，ＣＨ3 ＣＯＯＨ等の酸性物質とす
れば、前述と同様に腸内において選択的に薬剤が放出さ
れることになる。On the other hand, when the drug is released in the intestine, the dissolution film 38 is a fatty acid film that is digested by intestinal juice, and the bellows 3 is used.
If the chemical substance 48 provided around 4 is an acidic substance such as HCl, CH 3 COOH or the like that causes a chemical reaction with the intestinal fluid to generate heat, the drug is selectively released in the intestine as described above.
【００３８】したがって、第４の実施例と同様の効果が
得られる。図１０（ａ）（ｂ）は第６の実施例を示し、
第４，５の実施例と同一構成部分については同一番号を
付して説明を省略する。図１０（ａ）に示すように、カ
プセル５０の容器５１の内部に設けられたベローズ３４
の内壁には白金担持したＴｉＯ2 粒子５２が接着等によ
り固定して設けられ、ベローズ３４の内腔には電解液５
３が充填されている。Therefore, the same effect as that of the fourth embodiment can be obtained. 10A and 10B show a sixth embodiment,
The same components as those in the fourth and fifth embodiments are designated by the same reference numerals and the description thereof will be omitted. As shown in FIG. 10A, the bellows 34 provided inside the container 51 of the capsule 50.
Platinum-supported TiO 2 particles 52 are fixedly provided by adhesion or the like on the inner wall of the bellows 34.
3 is filled.
【００３９】ベローズ３４は透光性を有する材料で形成
されている。ベローズ３４の周囲には腸液等の消化液４
１と反応して発光する化学物質５４が設けられている。
この化学物質５４としては、例えば過酸化水素あるいは
次亜塩素酸塩とルミノールの混合物が用いられる。The bellows 34 is made of a light-transmitting material. Digestive fluid 4 such as intestinal juice around the bellows 34
A chemical substance 54 that reacts with 1 to emit light is provided.
As the chemical substance 54, for example, hydrogen peroxide or a mixture of hypochlorite and luminol is used.
【００４０】このように構成したカプセル５０を腸内で
選択的に薬剤を放出する場合について説明すると、患者
がカプセル５０を飲み込み、腸内に到達すると、脂肪酸
膜からなる溶解膜３８が溶解し、図１０（ｂ）に示すよ
うに、連通孔４６を介して腸液が容器５１内に浸入す
る。そして、腸液とルミノール、過酸化水素水（次亜塩
素酸塩）からなる化学物質５４が化学反応を起こし、３
５０〜６００ｎｍの発光を起こす。Explaining the case of selectively releasing the drug in the intestine with the capsule 50 thus constructed, when the patient swallows the capsule 50 and reaches the intestine, the dissolution film 38 made of a fatty acid film is dissolved, As shown in FIG. 10B, the intestinal fluid enters the container 51 through the communication hole 46. Then, the chemical substance 54 consisting of intestinal fluid, luminol, and hydrogen peroxide solution (hypochlorite) causes a chemical reaction, and 3
It emits light of 50 to 600 nm.
【００４１】この光は透光性のベローズ３４内のＴｉＯ
2 粒子５２に届き、光電気分解によりＨ2 ，Ｏ2 ガス５
５が発生する。そして、ベローズ３４は伸張し、バルー
ン３３を押圧するため、バルーン３３の内腔に充填され
た薬剤３５は連通孔３６を介して腸内に放出される。This light is emitted from the TiO in the transparent bellows 34.
2 Particles 52 reach H5 and O2 gas 5 by photoelectrolysis
5 occurs. Then, since the bellows 34 expands and presses the balloon 33, the drug 35 filled in the inner cavity of the balloon 33 is released into the intestine through the communication hole 36.
【００４２】したがって、第４，５の実施例と同様の効
果が得られる。図１１（ａ）（ｂ）は第７の実施例を示
し、第４〜６の実施例と同一構成部分については同一番
号を付して説明を省略する。図１１（ａ）に示すよう
に、カプセル５６の容器５７の内部に設けられたベロー
ズ３４の内腔には電解液溶液５８が充填されている。電
解液溶液５８としては水に塩化ナトリウム、塩化銅 (I
I),硫酸銅(II)等の電解質を溶解したものが用いられ
る。Therefore, the same effects as those of the fourth and fifth embodiments can be obtained. 11A and 11B show a seventh embodiment, and the same components as those in the fourth to sixth embodiments are designated by the same reference numerals and the description thereof will be omitted. As shown in FIG. 11A, an electrolyte solution 58 is filled in the inner cavity of the bellows 34 provided inside the container 57 of the capsule 56. As the electrolytic solution 58, water is mixed with sodium chloride and copper chloride (I
A solution in which an electrolyte such as I) or copper (II) sulfate is dissolved is used.
【００４３】また、ベローズ３４の端部には小型バッテ
リー５９と、これに接続された一対の電極６０が設けら
れている。一対の電極６０は電解質溶液５８に浸漬され
ている。また、カプセル５６の外周にはタイマースイッ
チ６１が設けられ、設定時間経過後、電極６０間に小型
バッテリー５９の電圧を印加可能となっている。A small battery 59 and a pair of electrodes 60 connected to the small battery 59 are provided at the end of the bellows 34. The pair of electrodes 60 is immersed in the electrolyte solution 58. Further, a timer switch 61 is provided on the outer periphery of the capsule 56 so that the voltage of the small battery 59 can be applied between the electrodes 60 after a lapse of a set time.
【００４４】このように構成したカプセル５６を胃内、
腸内で選択的に薬剤を放出する場合について説明する
と、まず、タイマースイッチ６１を操作してタイマーの
設定時間をカプセル５６が胃あるいは腸に到達する時間
にする。そして、タイマースイッチ６１をオンにし、患
者がカプセル５６を飲み込む。タイマーは設定時間にな
ると、スイッチオンとなり、小型バッテリー５９の電圧
が一対の電極６０間に印加される。In the stomach, the capsule 56 thus constructed is
The case of selectively releasing the drug in the intestine will be described. First, the timer switch 61 is operated to set the timer to the time for the capsule 56 to reach the stomach or the intestine. Then, the timer switch 61 is turned on, and the patient swallows the capsule 56. When the timer reaches the set time, the timer is switched on, and the voltage of the small battery 59 is applied between the pair of electrodes 60.
【００４５】電圧が印加されることで、電解質溶液５８
は電気分解を起こし、Ｈ2 ，Ｏ2 ガス５５が発生する。
そして、ベローズ３４は伸張し、バルーン３３を押圧す
るため、バルーン３３の内腔に充填された薬剤３５は連
通孔３６を介して胃内または腸内に放出される。したが
って、第４〜６の実施例と同様の効果が得られる。By applying voltage, the electrolyte solution 58
Causes electrolysis to generate H2 and O2 gas 55.
Then, since the bellows 34 expands and presses the balloon 33, the drug 35 filled in the inner cavity of the balloon 33 is released into the stomach or the intestine through the communication hole 36. Therefore, the same effects as those of the fourth to sixth embodiments can be obtained.
【００４６】[0046]
【発明の効果】以上説明したように、この発明によれ
ば、複数個のカプセルを弾性的な結合手段によって結合
すると共に、複数個のカプセルの互いの位置関係を検知
する位置検知手段を設け、検知した相対的な位置関係情
報を体外受信手段へ送信することにより、体腔内のおけ
るカプセルの位置確認を手軽に正確に行うことができる
と共に、カプセルの動きを高い精度で予測することがで
きる。As described above, according to the present invention, the plurality of capsules are coupled by the elastic coupling means, and the position detecting means for detecting the positional relationship of the plurality of capsules is provided. By transmitting the detected relative positional relationship information to the extracorporeal receiving means, the position of the capsule in the body cavity can be confirmed easily and accurately, and the movement of the capsule can be predicted with high accuracy.
【００４７】この結果、診断、治療をより正確に行うこ
とができ、またカプセルの前部が常に体腔内の前方を向
いているために観察像のオリエンテーションがつけ易
く、また所望の箇所でのアンビュレーションを容易に行
うことができる。As a result, diagnosis and treatment can be performed more accurately, and since the anterior part of the capsule always faces the front in the body cavity, it is easy to orient the observation image, and the anisotropy at the desired location is improved. It is possible to easily insulate.
【図１】この発明の第１の実施例を示し、医療用カプセ
ル装置の管腔内の進行状態を示す斜視図。FIG. 1 is a perspective view showing a first embodiment of the present invention and showing a state of progress in a lumen of a medical capsule device.
【図２】同実施例の作用説明図。FIG. 2 is an operation explanatory view of the same embodiment.
【図３】同実施例のカプセルの経路の算出についての説
明図。FIG. 3 is an explanatory diagram for calculating a route of a capsule according to the same embodiment.
【図４】この発明の第２の実施例を示し、医療用カプセ
ル装置の腸内の進行状態を示す正面図。FIG. 4 is a front view showing the second embodiment of the present invention and showing the progressed state in the intestine of the medical capsule device.
【図５】同実施例のカプセルの縦断側面図。FIG. 5 is a vertical sectional side view of the capsule of the same embodiment.
【図６】同実施例のカプセルと体外受信装置のブロック
図。FIG. 6 is a block diagram of a capsule and an extracorporeal receiving device according to the embodiment.
【図７】この発明の第３の実施例を示し、カプセルと体
外受信装置のブロック図。FIG. 7 is a block diagram of a capsule and an external receiver according to a third embodiment of the present invention.
【図８】この発明の第４の実施例を示し、カプセルの縦
断側面図。FIG. 8 is a vertical sectional side view of a capsule according to the fourth embodiment of the present invention.
【図９】この発明の第５の実施例を示し、カプセルの縦
断側面図。FIG. 9 is a vertical sectional side view of a capsule according to the fifth embodiment of the present invention.
【図１０】この発明の第６の実施例を示し、カプセルの
縦断側面図。FIG. 10 is a vertical sectional side view of a capsule according to a sixth embodiment of the present invention.
【図１１】この発明の第７の実施例を示し、カプセルの
縦断側面図。FIG. 11 is a vertical sectional side view of a capsule according to a seventh embodiment of the present invention.
【図１２】従来の医療用カプセル装置の管腔内の進行状
態を示す斜視図。FIG. 12 is a perspective view showing a state in which the medical capsule device according to the related art advances inside the lumen.
【図１３】従来のカプセルの経路の算出についての説明
図。FIG. 13 is an explanatory diagram of a conventional capsule route calculation.
１…第１のカプセル ２…第２カプセル ３…結合部材 ７…通信手段 ８…歪ゲージ DESCRIPTION OF SYMBOLS 1 ... 1st capsule 2 ... 2nd capsule 3 ... Coupling member 7 ... Communication means 8 ... Strain gauge
Claims (1)
セルを結合する弾性的な結合手段と、複数個のカプセル
の互いの位置関係を検知する位置検知手段と、検知した
相対的な位置関係情報を体外通信手段へ送信する通信手
段とを具備したことを特徴とする医療用カプセル装置。1. A plurality of capsules, an elastic connecting means for connecting the plurality of capsules, a position detecting means for detecting a positional relationship between the plurality of capsules, and a detected relative positional relationship. A medical capsule device, comprising: a communication means for transmitting information to an extracorporeal communication means.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25988293A JP3279409B2 (en) | 1993-10-18 | 1993-10-18 | Medical capsule device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25988293A JP3279409B2 (en) | 1993-10-18 | 1993-10-18 | Medical capsule device |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001303724A Division JP2002186672A (en) | 2001-09-28 | 2001-09-28 | Medical capsule device |
| JP2001303723A Division JP3568500B2 (en) | 2001-09-28 | 2001-09-28 | Medical capsule device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07111985A true JPH07111985A (en) | 1995-05-02 |
| JP3279409B2 JP3279409B2 (en) | 2002-04-30 |
Family
ID=17340256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25988293A Expired - Fee Related JP3279409B2 (en) | 1993-10-18 | 1993-10-18 | Medical capsule device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3279409B2 (en) |
Cited By (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000342527A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| JP2000342525A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| JP2000342524A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| JP2000342523A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| JP2003038424A (en) * | 2001-07-30 | 2003-02-12 | Olympus Optical Co Ltd | Encapsulated endoscope |
| JP2003038425A (en) * | 2001-07-30 | 2003-02-12 | Olympus Optical Co Ltd | Encapsulated endoscope |
| JP2003093367A (en) * | 2001-09-27 | 2003-04-02 | Olympus Optical Co Ltd | Capsule-type medical device |
| US6612982B1 (en) | 1999-06-07 | 2003-09-02 | Pentax Corporation | Fully-swallowable endoscopic system |
| KR100417163B1 (en) * | 2001-11-12 | 2004-02-05 | 한국과학기술연구원 | Micro capsule robot |
| KR100437262B1 (en) * | 2000-10-05 | 2004-06-23 | 한국과학기술원 | Smart Capsule Moving Unit for Intestines Examination |
| JP2004538055A (en) * | 2001-06-26 | 2004-12-24 | エントラック インコーポレイテッド | Diagnostic capsule and method of using the same |
| WO2005024687A1 (en) * | 2003-09-02 | 2005-03-17 | Fujitsu Limited | Medicine dosage management method, medicine, and medicine dosage management device |
| US6904308B2 (en) | 2001-05-20 | 2005-06-07 | Given Imaging Ltd. | Array system and method for locating an in vivo signal source |
| US6950690B1 (en) | 1998-10-22 | 2005-09-27 | Given Imaging Ltd | Method for delivering a device to a target location |
| US6951536B2 (en) | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
| US6958034B2 (en) | 2002-02-11 | 2005-10-25 | Given Imaging Ltd. | Self propelled device |
| JP2005334331A (en) * | 2004-05-27 | 2005-12-08 | Olympus Corp | Capsule dosing system |
| US7001329B2 (en) | 2002-07-23 | 2006-02-21 | Pentax Corporation | Capsule endoscope guidance system, capsule endoscope holder, and capsule endoscope |
| JP2006509574A (en) * | 2002-12-16 | 2006-03-23 | ギブン イメージング リミテッド | Apparatus, system, and method for selective actuation of in-vivo sensors |
| US7061523B2 (en) | 2001-11-06 | 2006-06-13 | Olympus Corporation | Capsule type medical device |
| US7076284B2 (en) * | 2001-10-16 | 2006-07-11 | Olympus Corporation | Capsulated medical equipment |
| US7109933B2 (en) | 2004-03-08 | 2006-09-19 | Pentax Corporation | Wearable jacket having communication function, and endoscope system employing wearable jacket |
| US7201872B2 (en) | 2000-01-19 | 2007-04-10 | Given Imaging Ltd. | System and method for determining the presence of a substance in-vivo |
| JP2007136208A (en) * | 2006-11-21 | 2007-06-07 | Olympus Corp | Capsule type endoscope for medical treatment |
| WO2007129655A1 (en) * | 2006-05-05 | 2007-11-15 | Olympus Medical Systems Corp. | Medical capsule |
| US7465271B2 (en) | 2003-09-01 | 2008-12-16 | Hoya Corporation | Capsule endoscope |
| EP1757099A4 (en) * | 2004-05-17 | 2009-05-20 | Given Imaging Ltd | Method, system and device for in-vivo biopsy |
| US7567692B2 (en) | 2005-09-30 | 2009-07-28 | Given Imaging Ltd. | System and method for detecting content in-vivo |
| US7577283B2 (en) | 2005-09-30 | 2009-08-18 | Given Imaging Ltd. | System and method for detecting content in-vivo |
| US7596403B2 (en) | 2004-06-30 | 2009-09-29 | Given Imaging Ltd. | System and method for determining path lengths through a body lumen |
| US7604589B2 (en) | 2003-10-01 | 2009-10-20 | Given Imaging, Ltd. | Device, system and method for determining orientation of in-vivo devices |
| JP2009270901A (en) * | 2008-05-07 | 2009-11-19 | Yoichi Kaneko | Method for measuring highly accurately three-dimensional position of passive rfid tag |
| US7647090B1 (en) | 2003-12-30 | 2010-01-12 | Given Imaging, Ltd. | In-vivo sensing device and method for producing same |
| JP2010005442A (en) * | 2001-05-20 | 2010-01-14 | Given Imaging Ltd | In vivo image sensing device |
| US7650180B2 (en) | 2003-07-02 | 2010-01-19 | Given Imaging Ltd. | Imaging sensor array and device and method for use therefor |
| JP2010012222A (en) * | 2008-06-06 | 2010-01-21 | Olympus Medical Systems Corp | Medical apparatus |
| US7704205B2 (en) | 2001-06-20 | 2010-04-27 | Olympus Corporation | System and method of obtaining images of a subject using a capsule type medical device |
| US7797033B2 (en) * | 2002-04-08 | 2010-09-14 | Smart Pill Corporation | Method of using, and determining location of, an ingestible capsule |
| US7869856B2 (en) | 2000-01-13 | 2011-01-11 | Moshe Refael | Encapsulated medical imaging device and method |
| US7988620B2 (en) | 2004-01-14 | 2011-08-02 | Olympus Corporation | Capsule endoscope apparatus |
| JP2011522585A (en) * | 2008-05-27 | 2011-08-04 | カプソ・ビジョン・インコーポレイテッド | Multi-stream image decoding apparatus and method |
| US8021356B2 (en) | 2003-09-29 | 2011-09-20 | Olympus Corporation | Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system |
| US8142350B2 (en) | 2003-12-31 | 2012-03-27 | Given Imaging, Ltd. | In-vivo sensing device with detachable part |
| US8368770B2 (en) | 2000-05-15 | 2013-02-05 | Given Imaging Ltd. | System and method for in-vivo imaging |
| US8406490B2 (en) | 2008-04-30 | 2013-03-26 | Given Imaging Ltd. | System and methods for determination of procedure termination |
| US8444554B2 (en) | 2001-05-20 | 2013-05-21 | Given Imaging Ltd. | Floatable in vivo sensing device and method for use |
| US8663093B2 (en) | 2006-04-03 | 2014-03-04 | Given Imaging Ltd. | Device, system and method for in-vivo analysis |
| US8696602B2 (en) | 2009-03-31 | 2014-04-15 | Given Imaging, Inc. | Method of determining body exit of an ingested capsule |
| US9375202B2 (en) | 2012-05-04 | 2016-06-28 | Given Imaging Ltd. | Device and method for in vivo cytology acquisition |
-
1993
- 1993-10-18 JP JP25988293A patent/JP3279409B2/en not_active Expired - Fee Related
Cited By (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7822463B2 (en) | 1998-10-22 | 2010-10-26 | Given Imaging Ltd. | Method for delivering a device to a target location |
| US6950690B1 (en) | 1998-10-22 | 2005-09-27 | Given Imaging Ltd | Method for delivering a device to a target location |
| JP2007196004A (en) * | 1998-10-22 | 2007-08-09 | Given Imaging Ltd | Method for delivering device to target location |
| US6402687B1 (en) | 1999-06-07 | 2002-06-11 | Asahi Kogaku Kogyo Kabushiki Kaisha | Fully-swallowable endoscopic system |
| JP2000342527A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| US6402686B1 (en) | 1999-06-07 | 2002-06-11 | Asahi Kogaku Kogyo Kabushiki Kaisha | Fully-swallowable endoscopic system |
| US6527705B1 (en) | 1999-06-07 | 2003-03-04 | Pentax Corporation | Fully-swallowable endoscopic system |
| JP2000342523A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| US6547723B1 (en) | 1999-06-07 | 2003-04-15 | Pentax Corporation | Fully-swallowable endoscopic system |
| US6612982B1 (en) | 1999-06-07 | 2003-09-02 | Pentax Corporation | Fully-swallowable endoscopic system |
| JP2000342524A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| JP2000342525A (en) * | 1999-06-07 | 2000-12-12 | Asahi Optical Co Ltd | Swallowable endoscope device |
| US7869856B2 (en) | 2000-01-13 | 2011-01-11 | Moshe Refael | Encapsulated medical imaging device and method |
| US7201872B2 (en) | 2000-01-19 | 2007-04-10 | Given Imaging Ltd. | System and method for determining the presence of a substance in-vivo |
| US8368770B2 (en) | 2000-05-15 | 2013-02-05 | Given Imaging Ltd. | System and method for in-vivo imaging |
| KR100437262B1 (en) * | 2000-10-05 | 2004-06-23 | 한국과학기술원 | Smart Capsule Moving Unit for Intestines Examination |
| US6904308B2 (en) | 2001-05-20 | 2005-06-07 | Given Imaging Ltd. | Array system and method for locating an in vivo signal source |
| US7618366B2 (en) | 2001-05-20 | 2009-11-17 | Given Imaging Ltd. | Array system and method for locating an in vivo signal source |
| JP2010005442A (en) * | 2001-05-20 | 2010-01-14 | Given Imaging Ltd | In vivo image sensing device |
| US8444554B2 (en) | 2001-05-20 | 2013-05-21 | Given Imaging Ltd. | Floatable in vivo sensing device and method for use |
| US7704205B2 (en) | 2001-06-20 | 2010-04-27 | Olympus Corporation | System and method of obtaining images of a subject using a capsule type medical device |
| JP2004538055A (en) * | 2001-06-26 | 2004-12-24 | エントラック インコーポレイテッド | Diagnostic capsule and method of using the same |
| US7727145B2 (en) | 2001-07-30 | 2010-06-01 | Olympus Corporation | Capsule-type medical device and medical system |
| US7993263B2 (en) | 2001-07-30 | 2011-08-09 | Olympus Corporation | Method and portable device for displaying an image from a capsule type medical device |
| JP2003038424A (en) * | 2001-07-30 | 2003-02-12 | Olympus Optical Co Ltd | Encapsulated endoscope |
| JP2003038425A (en) * | 2001-07-30 | 2003-02-12 | Olympus Optical Co Ltd | Encapsulated endoscope |
| US6951536B2 (en) | 2001-07-30 | 2005-10-04 | Olympus Corporation | Capsule-type medical device and medical system |
| JP2003093367A (en) * | 2001-09-27 | 2003-04-02 | Olympus Optical Co Ltd | Capsule-type medical device |
| US7083579B2 (en) | 2001-09-27 | 2006-08-01 | Olympus Corporation | Encapsulated medical device and method of examining, curing, and treating internal region of body cavity using encapsulated medical device |
| US7651471B2 (en) | 2001-09-27 | 2010-01-26 | Olympus Corporation | Encapsulated medical device and method of examining, curing, and treating internal region of body cavity using encapsulated medical device |
| US7942811B2 (en) | 2001-10-16 | 2011-05-17 | Olympus Corporation | Capsulated medical equipment |
| US8100888B2 (en) | 2001-10-16 | 2012-01-24 | Olympus Corporation | Capsulated medical equipment |
| US7076284B2 (en) * | 2001-10-16 | 2006-07-11 | Olympus Corporation | Capsulated medical equipment |
| US7061523B2 (en) | 2001-11-06 | 2006-06-13 | Olympus Corporation | Capsule type medical device |
| KR100417163B1 (en) * | 2001-11-12 | 2004-02-05 | 한국과학기술연구원 | Micro capsule robot |
| US6958034B2 (en) | 2002-02-11 | 2005-10-25 | Given Imaging Ltd. | Self propelled device |
| US7797033B2 (en) * | 2002-04-08 | 2010-09-14 | Smart Pill Corporation | Method of using, and determining location of, an ingestible capsule |
| US7001329B2 (en) | 2002-07-23 | 2006-02-21 | Pentax Corporation | Capsule endoscope guidance system, capsule endoscope holder, and capsule endoscope |
| US8216130B2 (en) | 2002-12-16 | 2012-07-10 | Given Imaging Ltd. | Device, system and method for selective activation of in vivo sensors |
| JP2006509574A (en) * | 2002-12-16 | 2006-03-23 | ギブン イメージング リミテッド | Apparatus, system, and method for selective actuation of in-vivo sensors |
| US7650180B2 (en) | 2003-07-02 | 2010-01-19 | Given Imaging Ltd. | Imaging sensor array and device and method for use therefor |
| US7465271B2 (en) | 2003-09-01 | 2008-12-16 | Hoya Corporation | Capsule endoscope |
| WO2005024687A1 (en) * | 2003-09-02 | 2005-03-17 | Fujitsu Limited | Medicine dosage management method, medicine, and medicine dosage management device |
| US10265139B2 (en) | 2003-09-02 | 2019-04-23 | Fujitsu Limited | Medicine ingestion state management method, medicine and medicine ingestion state management device |
| US9913698B2 (en) | 2003-09-02 | 2018-03-13 | Fujitsu Limited | Medicine ingestion state management method, medicine and medicine ingestion state management device |
| US10492887B2 (en) | 2003-09-02 | 2019-12-03 | Fujitsu Limited | Medicine ingestion state management method, medicine and medicine ingestion state management device |
| US8021356B2 (en) | 2003-09-29 | 2011-09-20 | Olympus Corporation | Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system |
| US7604589B2 (en) | 2003-10-01 | 2009-10-20 | Given Imaging, Ltd. | Device, system and method for determining orientation of in-vivo devices |
| US7647090B1 (en) | 2003-12-30 | 2010-01-12 | Given Imaging, Ltd. | In-vivo sensing device and method for producing same |
| US8142350B2 (en) | 2003-12-31 | 2012-03-27 | Given Imaging, Ltd. | In-vivo sensing device with detachable part |
| US7988620B2 (en) | 2004-01-14 | 2011-08-02 | Olympus Corporation | Capsule endoscope apparatus |
| US7109933B2 (en) | 2004-03-08 | 2006-09-19 | Pentax Corporation | Wearable jacket having communication function, and endoscope system employing wearable jacket |
| EP1757099A4 (en) * | 2004-05-17 | 2009-05-20 | Given Imaging Ltd | Method, system and device for in-vivo biopsy |
| JP2005334331A (en) * | 2004-05-27 | 2005-12-08 | Olympus Corp | Capsule dosing system |
| US7596403B2 (en) | 2004-06-30 | 2009-09-29 | Given Imaging Ltd. | System and method for determining path lengths through a body lumen |
| US7577283B2 (en) | 2005-09-30 | 2009-08-18 | Given Imaging Ltd. | System and method for detecting content in-vivo |
| US7567692B2 (en) | 2005-09-30 | 2009-07-28 | Given Imaging Ltd. | System and method for detecting content in-vivo |
| US8663093B2 (en) | 2006-04-03 | 2014-03-04 | Given Imaging Ltd. | Device, system and method for in-vivo analysis |
| JP5091125B2 (en) * | 2006-05-05 | 2012-12-05 | オリンパスメディカルシステムズ株式会社 | Medical capsule |
| WO2007129655A1 (en) * | 2006-05-05 | 2007-11-15 | Olympus Medical Systems Corp. | Medical capsule |
| JP2007136208A (en) * | 2006-11-21 | 2007-06-07 | Olympus Corp | Capsule type endoscope for medical treatment |
| US8406490B2 (en) | 2008-04-30 | 2013-03-26 | Given Imaging Ltd. | System and methods for determination of procedure termination |
| JP2009270901A (en) * | 2008-05-07 | 2009-11-19 | Yoichi Kaneko | Method for measuring highly accurately three-dimensional position of passive rfid tag |
| JP2011522585A (en) * | 2008-05-27 | 2011-08-04 | カプソ・ビジョン・インコーポレイテッド | Multi-stream image decoding apparatus and method |
| JP2010012222A (en) * | 2008-06-06 | 2010-01-21 | Olympus Medical Systems Corp | Medical apparatus |
| US8696602B2 (en) | 2009-03-31 | 2014-04-15 | Given Imaging, Inc. | Method of determining body exit of an ingested capsule |
| US9375202B2 (en) | 2012-05-04 | 2016-06-28 | Given Imaging Ltd. | Device and method for in vivo cytology acquisition |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3279409B2 (en) | 2002-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH07111985A (en) | Capsule apparatus for medical treatment | |
| CA2451807C (en) | Capsule and method for treating or diagnosing the intestinal tract | |
| JP3756797B2 (en) | Capsule type medical equipment | |
| JP5404817B2 (en) | Endoscope capsule | |
| JP4137740B2 (en) | Capsule type medical device and capsule type medical device guidance system | |
| JP4578740B2 (en) | Capsule medical device | |
| US20050096526A1 (en) | Endoscopy device comprising an endoscopy capsule or an endoscopy head with an image recording device, and imaging method for such an endoscopy device | |
| AU2002315385A1 (en) | Diagnostic capsule and method of use | |
| JP2004041709A (en) | Capsule medical care device | |
| US20070021654A1 (en) | Magnetically navigable endoscopy capsule with a sensor for acquiring a physiological variable | |
| JP2004321796A (en) | Computer-assisted three-dimensional image forming method for capsule endoscope device, wireless endoscope device, and medical technology device | |
| WO2005065521A1 (en) | System for sensing movement in subject | |
| WO2004091361A2 (en) | Optical capsule and spectroscopic method for treating or diagnosing the intestinal tract | |
| JP3568500B2 (en) | Medical capsule device | |
| CN102008319B (en) | Bidirectional color Doppler ultrasound capsule enteroscopy system | |
| WO2005087079A1 (en) | Device being introduced into subject body | |
| US20210353135A1 (en) | Modular capsule endoscope reconfigurable in digestive organ | |
| CN102008325B (en) | Color Doppler ultrasound capsule enteroscopy system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20020122 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090222 Year of fee payment: 7 |
|
| LAPS | Cancellation because of no payment of annual fees |