JPH07196523A - Internal liquid preparation containing quercetin glycoside - Google Patents

Abstract

(57) [Summary] [Object] The present invention provides a quercetin glycoside, a divalent metal ion, and a licorice extract as essential components to prevent a metal ion deficient in the human body from being consumed by a person. A quercetin glycoside that not only replenishes but also promotes metabolic functions in the liver to maintain a healthy body condition, recover fatigue, improve physical condition and give vitality, and further wake up in the morning. The object is to provide an internal liquid preparation containing the body. The present invention is a liquid agent for supplementing a human body with a shortage of metal ions when it is ingested by a person, and promoting a metabolic function in licorice to maintain a healthy physical condition. The liquid agent is a glycoside of quercetin. It is characterized in that the body, divalent metal ions and licorice extract are essential components.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a quercetin glycoside and an internal liquid preparation containing a quercetin glycoside containing a divalent metal ion and a licorice extract as essential components. Thus, the present invention relates to a liquid preparation for internal use containing quercetin glycoside, which supplements the human body with insufficient metal ions and promotes the metabolic function in licorice, thereby keeping the physical condition healthy.

[0002]

2. Description of the Related Art Conventionally, various pharmaceuticals have been manufactured and sold in terms of human health management and health maintenance, but in the field of internal liquid preparations, daily supply of nutrients that the body lacks is supplemented. In addition, many products for the purpose of health management and health maintenance are manufactured and sold, and are widely used as pharmaceuticals because they can be easily taken.

As components of these internal liquid preparations, vitamins such as vitamin B ₁ and vitamin B ₂ , vitamin ₆ , vitamin C and vitamin E, amino acids or salts of amino acids, nicotinic acid amide, taurine, calcium lactate and chloride are included. Metal salts such as potassium and magnesium chloride, that is, minerals,
Garlic, Korean carrot, Ganoderma lucidum, Oomu, Ground yellow, Guarana,
Various ingredients such as extracts of various herbal medicines such as beef yellow, caffeine, royal jelly, γ-oryzanol and the like are blended.

Further, these internal liquid agents include sweeteners, acidulants,
A flavoring agent, a flavoring agent, a coloring agent and the like are simultaneously mixed.

These components are either dissolved or dispersed in the internal liquid preparation.

[0006]

These internal liquid preparations are
It is mainly intended for health management and health maintenance such as nutritional supplementation, nutritional tonicity, physical fatigue and stiff shoulders, relief of eye strain, etc., and various ingredients are blended as described above depending on the purpose, and It has a reasonable value and effect.

[0007] However, these internal liquid preparations are widely taken because they can be easily taken, and have the effect of supplementing nutritional components that tend to be deficient to the living body, but recover fatigue, maintain physical condition, and vitalize. It was not sufficient for the application of the above, alleviation of eye strain, etc.

[0008] The present inventor has paid attention to the fact that a food containing young buckwheat leaves as an active ingredient has a very excellent effect in maintaining a good physical condition, and has conducted intensive studies on the ingredients of young buckwheat leaves. As a result, it was found that rutin, which is a glycoside of quercetin, and its components, such as divalent metal ions such as calcium ion and magnesium ion, are index substances that express the effectiveness of buckwheat young leaves.

In addition, when licorice extract containing glycyrrhizin is added to young leaves of buckwheat, it has a very excellent effect in preventing and responding to fatigue, malaise, and feeling of collapse, and in relieving eye strain. I found it.

Such a feeling of fatigue, malaise, discomfort, asthenopia, etc. is something that anyone experiences in a stressful modern society, especially when working in an intensely tense state or irregularly. This can be a real pain if you are forced to live or eat properly.

However, fatigue, malaise, lassitude, asthenopia and the like are not recognized as illnesses, are often left untreated, and are in the range of indefinite complaints. In order to maintain a healthy life, we have added licorice extract containing glycyrrhizin and rutin, which is a glycoside of quercetin, which is an effective indicator substance of young leaves of buckwheat, and glycyrrhizin. At the very least, daily intake is very significant.

That is, the present inventor is said to be effective for the treatment of capillary bleeding and various bleeding and for high blood pressure, and further contains a glycoside of quercetin having an antioxidant effect,
It also forms a complex with the glycoside of quercetin, which is a mineral that affects the retention of the osmotic pressure of body fluids and the electrolyte balance such as acid-alkali equilibrium, and is a substance that regulates physiological functions such as stimulatory transmission of muscles and nerves. We examined divalent metal ions that interact with each other, such as those containing calcium ions, magnesium ions, and zinc ions. These minerals are indispensable to the living body. It has been found that by blending with glycosides, it maintains various functions of the living body and plays an important role in recovery of body modulation.

The present inventor has also reported that quercetin glycosides and 2
By using a licorice extract containing a valent metal ion and glycyrrhizin as an essential component, this licorice extract promotes the metabolic function in the liver and alleviates the burden, and the liver damage inhibitory action and microsomal metabolic enzyme, or , Has a function of acting on cell membranes and the like to suppress damage caused by harmful substances, 2
A feeling of fatigue due to a synergistic action with calcium ions, magnesium ions, zinc ions, etc., which are valent metal ions,
They found that they could improve fatigue and feelings of weakness.

In the field of pharmaceuticals, it is more significant to use these substances as liquid solutions for internal use in order to make them into a form that can be easily ingested on a daily basis. Of the effective components, rutin and glycyrrhizin are poorly soluble in water when the components are to be drunk as an aqueous solution. In particular, the presence of metal ions further deteriorates the water solubility.

Therefore, in the liquid preparation for internal use of the present invention, a water-soluble ingredient is used as each active ingredient, the ingredient is solubilized in water, or each ingredient is dispersed. Compared to the usual dose as a normal drug, the intake amount is an extremely small amount, which improves the physical condition, and by maintaining it, it has the effect of improving fatigue, malaise, and feeling of collapse. is there.

As described above, although the quercetin glycoside and the liquid preparation for internal use containing the divalent metal ion and the licorice extract as essential components have remarkably excellent effects, they still exist as pharmaceuticals. The present situation is that there is none, and the present invention has been completed in view of such points.

The present invention is intended to solve the above technical problems, and comprises a quercetin glycoside, a divalent metal ion and an extract of licorice as essential components, so that the human body can drink the human body. By supplementing the lack of metal ions in the liver and promoting metabolic function in the liver,
The purpose of the present invention is to provide an internal solution containing quercetin glycoside, which keeps the physical condition healthy, and recovers fatigue, adjusts physical condition and gives vitality, and further wakes up in the morning. To do.

[0018]

In order to achieve the above object, an internal liquid preparation containing the quercetin glycoside of the present invention (hereinafter simply referred to as an internal liquid preparation) takes the following technical means. It is a thing.

That is, the liquid preparation for internal use of the present invention is a liquid preparation for supplementing metal deficiency in the human body when the human drinks it, and promoting the metabolic function in licorice to keep the physical condition healthy. This liquid preparation is characterized by containing a glycoside of quercetin, a divalent metal ion and a licorice extract as essential components.

The present invention will be described in detail below. The glycoside of quercetin used in the present invention is not particularly limited, but is particularly a glycoside of water-soluble quercetin, that is, a water-soluble rutin or a solubilized quercetin included by cyclodextrin. Glycosides are most desirable from the viewpoints of ease of formulation design, absorbability into the living body, and stability of the formulation.

As water-soluble rutin as a glycoside of quercetin, α containing a sugar having a plurality of glucose
-Glycosyl rutin. Also, an inclusion compound of rutin cyclodextrin obtained by a conventional method may be used.

By the way, the quercetin glycoside rutin is
It is contained in Enju, Soba, and citrus fruits, and is extremely safe.

In addition, the liquid preparation for internal use of the present invention contains the above-mentioned glycoside of quercetin, a divalent metal ion and a licorice extract as essential components.

Examples of the divalent metal ion include at least one of calcium ion, magnesium ion and zinc ion.

In the present invention, calcium, magnesium or zinc is not particularly limited as long as it can exist in an ionic form in a liquid preparation for internal use, but it is generally used as an internal medicine or food. Those are preferable from the viewpoint of safety.

That is, the calcium compound is not particularly limited as long as it has a solubility of 0.05 g / 100 ml or more, and specific examples thereof include calcium lactate, calcium gluconate, calcium pantothenate, and sulfuric acid. Examples thereof include calcium, calcium chloride, calcium propionate, calcium phosphate, and bone ion, shell of shell, egg shell, etc., which are natural sources of calcium, ionized to be water-soluble.

The magnesium compound is not particularly limited as long as it has a solubility of 0.05 g / 100 ml or more, and specific examples thereof include magnesium chloride, magnesium sulfate, magnesium oxide and magnesium stearate. Can be mentioned.

Further, the zinc compound has a solubility of 0.0.
It is not particularly limited as long as it is 5 g / 100 ml or more, and specific examples thereof include zinc sulfate and zinc gluconate.

Further, plant-derived extracts such as buckwheat leaves and barley leaves, especially extracts of these young leaves, contain calcium and magnesium and can be usefully utilized.

The internal liquid preparation of the present invention is said to be effective for the treatment of capillary bleeding and various bleeding and for high blood pressure, and further contains a glycoside of quercetin having an antioxidant effect, and further It has effects such as retention of osmotic pressure and electrolyte balance such as acid-alkali equilibrium, and also interaction such as forming a complex with quercetin glycoside among minerals which are physiological function regulating substances such as stimulation transmission of muscle nerves. In addition to those containing calcium ions, magnesium ions, and zinc ions, which are divalent metal ions, they promote the metabolic function in the liver to relieve the burden, and the liver damage inhibitory action and microsomal metabolic enzyme. In addition, it is surprising to add a licorice extract containing glycyrrhizin, which is said to have a function of acting on cell membranes and the like to suppress damage caused by harmful substances. Bets on, by the interaction of these components, improve the physical condition in good condition, by holding, fatigue, malaise, it is possible to improve such lethargy effectively.

By the way, licorice is a perennial plant of the legume family that grows naturally in northern China and uses roots. However, because it has a special sweetness, it is used as a flavoring agent or sweetener, including related plants. Since ancient times, it has been used in the food field as a sweetener for miso and soy sauce, and as a flavoring agent and sweetener for various other foods, and has also been widely used for other purposes such as flavoring agents and sweeteners in the pharmaceutical field. It is highly safe.

The licorice extract used in the present invention is a licorice extract obtained by extracting components from the licorice by various methods. In particular, the content of the main component glycyrrhizin, that is, glycyrrhizic acid, which is free glycyrrhizin, is determined. Extracts that ensure quality are easy to use and preferred.

Glycyrrhizin is a general term for glycyrrhizinic acid or salts of glycyrrhizinic acid. Since it is sparingly soluble in water in the acidity range of usual liquid medicines for internal use, it is soluble in cyclodextrin by a known method and is soluble. It is preferable to use those obtained by

This glycyrrhizin hydrolyzes one molecule in the body to produce two molecules of glucuronic acid, which prevents detoxification, that is, the adverse effect of the toxin on the body by strongly forming a conjugate with the toxin. In addition, it enhances adrenocortical hormones, decholesterolemia and arteriosclerosis, and promotes metabolism of various substances, and further improves liver function and protects the liver.

As described above, when an internal liquid preparation comprising a quercetin glycoside, a divalent metal ion and a licorice extract containing glycyrrhizin is ingested, the amount of each component ingested is small due to their interaction in the body. Even so, by improving and maintaining the physical condition, fatigue, fatigue, feeling of collapse, etc. are improved.

The liquid preparation for internal use of the present invention contains the above-mentioned components as essential components. However, if desired, various water-soluble or solubilized components are added to improve the taste and sensation during drinking, and You may fortify your nutrition.

For this purpose, for example, white sugar, fructose,
Glucose, oligosaccharides, fructooligosaccharides, maltose, stevia, honey, potassium chloride, glycerin, dextrin, CMC, carotenoids and vitamins such as vitamin B ₁ , vitamin B ₂ , vitamin B ₆ and vitamin E, amino acids or salts thereof, Nicotinic acid amide, taurine, garlic and ginseng, ganoderma lucidum, ginseng, ginseng and other various crude drug extracts, niacin, royal jelly, γ-oryzanol, flavoring agents, sweeteners, flavoring agents, solvents, enhancing agents, etc. It may contain additives such as a sticky agent, a flavoring agent, a preservative, a surfactant, a health promoting agent, a nutritional supplement, and a nutritional enhancer.

It is extremely convenient that the liquid preparation for internal use of the present invention is divided into small portions and sealed in a light-shielding glass bottle or the like so that a single dose can be easily understood, and at the same time, it blocks ultraviolet rays and the air from the outside. This can prevent alteration. In this case, a dose of 25 to 100 ml is generally used as a single dose.

In the liquid medicine for internal use of the present invention, the mixing ratio of each component is not particularly limited as long as it is a desired ratio for exerting the effect.

The liquid preparation for internal use of the present invention contains 0.005 to 1% by weight of quercetin glycoside (A) in terms of rutin and 0.2% of divalent metal ion (B) in the above beverage. 0
01 to 1% by weight, and glycyrrhizin whose licorice extract (C) is the active ingredient is 0.0 as free glycyrrhizin.
It is beneficial that it is from 05 to 0.5% by weight.

The content of the component (A) is 0.005% by weight.
If the amount is less than the above, there is a possibility that the synergistic effect of the components of the liquid for internal use may not be sufficiently utilized, and the effect becomes poor. On the other hand, if it is 1% by weight or more, the above (B) and
It is not preferable because the balance with the component (C) is lost, the synergistic effect is poor and the meaning is lost, and it is uneconomical. For these reasons, the content of the component (A) is preferably 0.01 to 0.5% by weight in terms of rutin.

Here, in determining the blending ratio of the component (A), the rutin conversion is used for the following reason.

That is, in quercetin glycosides, the molecular weight varies depending on the type of sugar in the glycoside, and these sugars provide quercetin glycoside as a water-soluble component to the liquid preparation for internal use. In addition, any quercetin glycoside is decomposed into quercetin and sugar in the body, which is the most typical component of quercetin glycoside,
This is because the purpose of the present invention is to be converted on the basis of widely used rutin.

On the other hand, in the above (B), when the content of the divalent metal ion is less than 0.001% by weight, the significance of blending becomes small and the interaction with the above component (A) cannot be expected, so that On the other hand, the effect may be poor, while if it exceeds 1% by weight, it is uneconomical for the purpose of the internal use liquid preparation of the present invention and it is uneconomical. It is not preferable because it may cause precipitation, or the flavor of the liquid preparation for internal use may be deteriorated. For these reasons, (B) above
The content of the component is preferably in the range of 0.002 to 0.5% by weight.

In the content of the above component (C), when the content of glycyrrhizin as an active ingredient thereof is less than 0.005% by weight as free glycyrrhizin, the effect of glycyrrhizin itself becomes poor, or the above (A) ) And (B) are out of balance with each other and the interaction becomes poor, so that the effect may not be expected. On the other hand,
If it exceeds 0.5% by weight, the balance with the components (A) and (B) is disturbed, the flavor is deteriorated, and the value of the liquid preparation for internal use is decreased. In addition, precipitation may occur. It is not preferable because it occurs.

Therefore, it is desirable that the content of glycyrrhizin, which is the active ingredient, as free glycyrrhizin is 0.01 to 0.3% by weight, as the blending ratio of the above-mentioned component (C).

As described above, in this internal liquid preparation,
In determining the blending ratio of the component (C), the ratio of glycyrrhizin, which is the active ingredient, is used for the following reasons.

That is, since licorice is a natural product, there are various grades of glycyrrhizin, which is an active ingredient, of about 2 to 5% by weight, and various components are mixed in the extract derived from licorice. To do. Therefore, it is extremely important to use the grade, which is the active ingredient, as the indicator substance in order to achieve the object of the present invention.

Further, glycyrrhizin, which is an active ingredient of licorice extract, is an acidic substance, exists as a free acid in an acidic aqueous solution, and because of its poor solubility, cyclodextrin inclusion bodies can be used. .

The method of incorporating the licorice extract with cyclodextrin may be any known method.

The above-mentioned liquid preparation for internal use of the present invention includes those containing the above-mentioned various additives as components of the beverage, and the mixing ratio of this additive is a desired amount for achieving the mixing purpose. This makes it possible to improve the flavor of the liquid preparation for internal use, make it easier to drink, and improve its function.

Furthermore, by subdividing the above liquid medicine for internal use and sealing it in a container such as a light-shielding glass bottle, it is possible to block the outside air, prevent the influence of ultraviolet rays, and prevent alteration, and at the same time, drink once. It is extremely convenient because the amount can be easily understood.

In the present invention, quercetin glycoside (A)
In addition, the divalent metal ion (B) and the licorice extract (C) containing vitamin C and / or organic acid (D) as essential components are also useful.

The present invention is one in which the above-mentioned liquid preparation for internal use contains vitamin C and / or an organic acid, and the components (A), (B) and (C) used here are the above-mentioned components. The description is omitted because it is the same as the liquid medicine.

As described above, when vitamin C among the components (D) is contained in the above-mentioned internal liquid preparation, the stability and absorbability of the quercetin glycoside in the internal liquid preparation are improved and the quercetin glycoside is improved. The effect of enhancing the peripheral blood vessels by the glycoside is further improved.

Furthermore, vitamin C promotes a diuretic effect,
It has a function of excreting toxins in the body out of the body at an early stage to restore the normal activity of the body.

In addition, in the above-mentioned internal liquid preparation, which contains the organic acid among the components (D), an organic acid is contained,
Moreover, when the pH thereof is 2.5 to 5, the stability and absorbability of the quercetin glycoside in the liquid preparation for internal use are improved, and at the same time, it is absorbed and promotes activation of cells, and further the organic acid is added. The presence of glycerin enhances the stability of quercetin glycosides and vitamin C.

The organic acid used here is not particularly limited as long as it is an organic acidic substance which can be used for medicines and foods, and specific representative examples thereof include citric acid, malic acid, and tartaric acid. And the like, and these can be used alone or in combination of two or more kinds.

Of these organic acids, citric acid is preferred from the viewpoint of degrading lactic acid, pyrogluconic acid and the like in the body and preventing acidification of blood.

Further, this internal liquid agent is the same as in the above case.
By incorporating various additives, the liquid preparation for internal use can be improved in flavor and can be easily drunk, and its function can be improved.

Further, similarly to the above case, it is preferable to take measures such as subdividing the light-shielding bottle to prevent alteration.

In the liquid medicine for internal use of the present invention, the compounding ratio of each component is not particularly limited as long as it is a desired ratio to exert the effect.

The internal liquid preparation of the present invention contains 0.005 to 1% by weight of quercetin glycoside (A) in terms of rutin and 2 binary metal ions (B) in the above beverage. ．
001 to 1% by weight, and glycyrrhizin, which is an active ingredient of licorice extract (C), was used as free glycyrrhizin.
Those containing 005 to 0.5% by weight and 0.01 to 2% by weight of vitamin C and / or organic acid (D) are extremely useful.

In the liquid preparation for internal use of the present invention, the above (A),
The reasons for specifying the components (B) and (C) are the same as those for the above-mentioned internal liquid preparation, and therefore will be omitted to avoid redundant description. The reason why the component (D) is specified here is as follows.

That is, as described above, among the above-mentioned components (D), vitamin C improves the stability and absorbability of quercetin glycoside in the liquid preparation for internal use, and the effect of quercetin glycoside for enhancing peripheral blood vessels and the like. Is further improved, and further, the diuretic action is promoted, and the toxins in the body are released to the outside of the body at an early stage, whereby the reduced function of the body is normally restored.

On the other hand, when the organic acid is contained in the above component (D), the stability and absorbability of the quercetin glycoside in the liquid preparation for internal use are improved, and at the same time, it is absorbed to promote the activation of cells. In addition, the presence of organic acids enhances the stability of quercetin glycosides and vitamin C.

However, in the liquid preparation for internal use of the present invention, when the content of vitamin C and / or organic acid in the component (D) is less than 0.01% by weight, the stability and absorbability of quercetin glycoside are insufficient. In addition to the possibility that the synergistic effect may be poor, it may not be possible to promote the cell activating action, and there arises a problem that the internal solution cannot obtain the desired acidity, while vitamin C And / or if the organic acid exceeds 2% by weight, the balance with other components such as the components (A), (B) and (C) is lost, the flavor and the feeling of drinking are reduced, and the value as a beverage is reduced. However, the acidity becomes too strong, which may cause precipitation of components, which is not preferable.

Therefore, the content of the component (D) is preferably 0.05 to 1% by weight, particularly vitamin C and / or organic acid.

In the present invention, the above-mentioned internal liquid preparation includes the internal liquid preparation containing the above-mentioned various additives, but the description is omitted because it is the same as described above. The container is also the same as described above, and will not be described.

[0070]

The liquid preparation for internal use of the present invention has the above constitution and contains quercetin glycoside, divalent metal ion and licorice extract as essential components.

Rutin, which is a typical example of quercetin glycoside, is a component contained in buckwheat, etc. Soba has been eaten in a wide area for a long time since ancient times, and is a divalent metal ion, calcium. , Magnesium and zinc are present in various foods and are indispensable components for maintaining the living body. Licorice and extracts derived from licorice are also flavoring agents and sweeteners for medicines and foods. Have been widely used, and all are extremely safe.

Further, quercetin glycoside is said to be effective for the treatment of capillary bleeding and various bleeding, and it is said that it has an antioxidant action. It protects peripheral blood vessels against elevation and increased circulation of blood and body fluids. In addition, it is a physiological regulator that affects the retention of osmotic pressure of body fluids and the electrolyte balance such as acid-alkali equilibrium, and also stimulates the transmission of muscles and nerves.
Further, by containing at least one of divalent metal ions, calcium ion, magnesium ion and zinc ion, which have an interaction such as forming a complex with quercetin glycoside, restoration of the function of the living body is achieved. Further, by containing a licorice extract, glycyrrhizin as an active ingredient promotes metabolism of various substances in the liver to alleviate the burden thereof, and liver damage suppression and microsomal metabolic enzymes, or It is said to act on cell membranes and suppress various disorders, and glucuronic acid produced by the decomposition of glycyrrhizin in the body expresses a detoxification effect by forming a conjugate with a toxin and promotes metabolism. In addition, it exhibits a detoxification effect, liver function improvement and protection effect, and promotes bile secretion.

And, by improving the physical condition by a synergistic action of these components and maintaining it,
By improving the feeling of fatigue, malaise, and feeling of collapse, and by providing it as an internal solution which is an aqueous solution, it has the effect of safely and easily drinking anytime, anywhere and maintaining a healthy condition.

When the internal liquid preparation of the present invention further contains vitamin C and / or an organic acid, the vitamin C
Not only enhances the absorption and stability of quercetin glycosides, but also interacts with quercetin glycosides to exert a synergistic effect on the digestive and circulatory organs, which results in the metabolism of substances. It is promoted to further improve tiredness, malaise, discomfort, and the like, and by containing the organic acid, quercetin glycosides and vitamin C can be further stabilized and cell activation can be achieved. In particular, the use of citric acid has the effect of degrading lactic acid, pyroglucose and the like in the body to prevent acidification of blood.

As described above, surprisingly, in the liquid preparation for internal use of the present invention, the feeling of fatigue,
In addition to improving fatigue and lethargy, it has the effect of preventing and preventing fatigue, fatigue, lethargy and the like.

[0076]

EXAMPLES The present invention will now be described in detail based on examples, but the present invention is not limited thereto.

Example 1 Cyclodextrin inclusion body of rutin 3.0% by weight Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Cyclodextrin inclusion body of licorice extract 3.0% by weight Citric acid 0.6% by weight % Sodium benzoate 0.05% by weight Glucose fructose syrup 10.0% by weight Fragrance Trace amount of purified water 83.05% by weight An internal solution comprising the above components was obtained by a conventional method.

Example 2 α-Glycosyl rutin 0.1% by weight Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Cyclodextrin inclusion body of licorice extract 3.0% by weight Citric acid 0.6% by weight Benzoic acid Sodium acid 0.05% by weight Dextrose fructose liquid sugar 10.0% by weight Perfume Trace amount of purified water 85.95% by weight An internal solution comprising the above components was obtained by a conventional method.

Example 3 α-Glycosyl rutin 0.1% by weight Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Cyclodextrin inclusion body of licorice extract 3.0% by weight Vitamin C 0.2% by weight citric acid Acid 0.4% by weight Sodium benzoate 0.05% by weight Glucose fructose syrup 10.0% by weight Perfume Micro amount of purified water 85.95% by weight An internal solution comprising the above components was obtained by a conventional method.

Example 4 α-Glycosyl rutin 0.1% by weight Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Glycyrrhizin cyclodextrin inclusion body 1.5% by weight Vitamin C 0.2% by weight Citric acid 0 0.4% by weight Sodium benzoate 0.05% by weight Glucose fructose syrup 10.0% by weight Perfume Micro amount of purified water 87.45% by weight An internal solution comprising the above components was obtained by a conventional method.

Comparative Example 1 α-Glycosyl rutin 0.1% by weight Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Vitamin C 0.2% by weight Citric acid 0.4% by weight Sodium benzoate 0.05% by weight % Glucose Fructose liquid sugar 10.0% by weight Perfume Trace amount of purified water 88.95% by weight An internal solution comprising the above components was obtained by a conventional method.

Comparative Example 2 α-Glycosyl rutin 0.1% by weight Cyclodextrin inclusion body of licorice extract 3.0% by weight Vitamin C 0.2% by weight Citric acid 0.4% by weight Sodium benzoate 0.05% by weight Glucose Fructose liquid sugar 10.0 wt% Fragrance Trace amount Purified water 86.25 wt% An internal liquid preparation comprising the above components was obtained by a conventional method.

Comparative Example 3 Calcium lactate 0.2% by weight Magnesium chloride 0.1% by weight Cyclodextrin inclusion body of licorice extract 3.0% by weight Vitamin C 0.2% by weight Citric acid 0.4% by weight Sodium benzoate 0.05% by weight glucose-fructose syrup 10.0% by weight Fragrance trace amount of purified water 86.05% by weight An internal solution comprising the above components was obtained by a conventional method.

Comparative Example 4 Nicotinic acid amide, vitamin B ₁ nitrate, anhydrous caffeine, taurine and the like were used as active ingredients, and sugar, acidulant, fragrance and the like were added, and physical fatigue, post-disease illness, loss of appetite, nutrition A commercial product (capacity of 1 bottle is 100 ml) that has the effects of nutritional supplementation, nutritional tonicity, and collapse constitution in the case of disorders.

Comparative Example 5 Vitamin B ₁ nitrate, Vitamin E acetate, sodium chondroitin sulfate, oxoamidine and the like as active ingredients, sugar, acidulant, fragrance and the like were added, and muscle pain / joint pain (backache, stiff shoulder, etc.)・ Commercial products whose effects are to relieve numbness of hands and feet, eye strain, etc., and to supplement vitamin B ₁ for physical fatigue, lactation during pregnancy, decline in physical strength after illness, etc.
(The capacity of one bottle is 30 ml).

Cyclodextrin inclusion bodies of rutin used in the examples and comparative examples, α-glycosyl rutin,
As the cyclodextrin inclusion body of licorice extract and the cyclodextrin inclusion body of glycyrrhizin, the following were used.

1. As a cyclodextrin inclusion body of rutin, one having a rutin content of 2.8% by weight in the inclusion body was used. 2. α-glycosyl rutin has a rutin content of 3
6.6 wt% was used. 3. As the cyclodextrin inclusion body of the licorice extract, the content of free glycyrrhizin in the inclusion body, that is, glycyrrhizic acid was 1.6% by weight. 4. As the cyclodextrin inclusion body of glycyrrhizin, a cyclodextrin inclusion body was produced with a purity of 98.5% by weight glycyrrhizic acid, and free glycyrrhizin in the inclusion body, that is, a content of 3.5% by weight as glycyrrhizic acid was used. .

Further, in each of Examples 1 to 4 and Comparative Examples 1 and 2, each was put in a 50 ml brown light-shielding bottle and tightly closed.

Test 1 Regarding Example 1, a person who complains that he / she is easily tired and does not usually feel tired, or feels tired somehow,
5 males (aged 36 to 61), 15 females (aged 45 to 45)
68 years old).

As a result of drinking 50 ml of 1 bottle twice a day for 7 consecutive days, 8 were reported to be tired.
7 people reported that they were less tired,
Five people reported the same as before or did not know the result.

Test 2 Example 2, Example 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3
The following tests were conducted on the.

That is, the panelists selected those who felt uncomfortable in the morning, had a vague feeling of head when they woke up, and felt tired from the previous day, and felt uncomfortable somehow.

This panel consists of 19 males (ages 32-5
There are a total of 45 people (8 years old) and 26 women (ages 25 to 55 years old).

Test Method The 45 persons were randomly divided into 9 persons per group, and the above-mentioned Example 2
With respect to 3, 5 items of Comparative Examples 1 and 2, and 1 item per group, 50 ml of each bottle was drunk once a day, once a day after dinner and before bedtime. The drinking period was 10 days, and the state of waking up in the morning (evaluation 1) and the state when waking up (evaluation 2) were evaluated. The results are shown in Table 1.

[0095]

[Table 1]

In Table 1, A to D in Evaluation 1 indicate the number of persons who complained the following states, and E to H in Evaluation 2 indicate the number of persons who complained the following states.

Evaluation 1 A: The morning awakening has improved significantly. B: I woke up better in the morning. C: It's unclear if it works. D: Same as before.

Evaluation 2 E: The condition when waking up is much better than before. (He has a refreshed head and does not have the fatigue of the previous day.) F: The condition when waking up is better than before. G: I don't know if it will work. H: The condition when waking up is the same as before.

Test 3 The following tests were carried out on Example 4, Comparative Example 4 and Comparative Example 5. That is, 60 panelists (28 males: 30-65)
(Age, 32 females: 27 to 66 years old), and is usually tired or tired easily, does not feel well, has somehow heavy head and depression, does not wake up well, has good head and body when waking up Panelists were those who complained of so-called indefinite complaints such as stiff shoulders when tired and stiff stomach when tired.

The panelists were randomly divided into 3 groups with 20 persons in each group, and Example 4, Comparative Example 4 or Comparative Example 5 was given to each group for one item.

Regarding drinking, in Example 4, 50 ml per bottle,
In Comparative Example 4, the capacity of the product is 100 ml per bottle, and in Comparative Example 5, the capacity of the product is 30 ml per bottle, each of which is 1 bottle once a day, and drinking is performed without restriction of drinking time. I tightened it up. The drinking period was 14 days. The results are shown in Table 2.
Shown in.

[0102]

[Table 2]

The criteria shown in Table 2 are that the body is tired or prone to fatigue, somehow does not feel good, somehow has a heavy head and is depressed, does not wake up easily, has no good head and body when waking up, and has stiff shoulders when tired. For the daily conditions such as easy wakeup and heavy stomach, the improvement condition was evaluated.

Evaluation A: Very effective. B: There was an effect. C: It has a little effect. Or it seems to be effective. D: I don't know if it will work. Or, it is difficult to judge. E: Same as before.

Test 4 For Example 4 and Comparative Example 5, the following drinking test was conducted. That is, 36 women (aged 19 to 45 years old) who constantly abuse their eyes, such as operators of office equipment and clerical work, and complain of eyestrain were panelists. These panelists were divided into 2 blocks of 18 people so that they would not become uneven considering the symptoms.

50 ml of 1 bottle of the product of Example 4 was added to one block of the above two blocks of panelists 2 times a day.
A total of 100 ml was drunk after the meal, after breakfast and after dinner. The drinking period was 7 days.

The remaining one of the two block panelists
The block panelists drunk 30 ml of the bottle of Comparative Example 5 twice a day for a total of 60 ml after breakfast and after dinner.
The drinking period was 7 days. The results are as follows.

As a result, in Example 4, 3 persons reported that eye strain was remarkably improved, and 8 persons complained that the eye strain was improved or the eyes became easier.

On the other hand, in Comparative Example 5, only 4 people complained that their eyestrain was improved or their eyes became easier.

From the above test results, the liquid preparation for internal use of the present invention is
It is effective in improving and preventing daily uncomfortable feelings such as fatigue and malaise, keeps the physical condition healthy, and improves morning awakening, improves fatigue, and improves eye fatigue. It is recognized that prevention is very effective in improving physical condition and energizing daily activities such as work.

[0111]

The liquid preparation for internal use of the present invention has the above constitution,
The liquid agent is extremely safe as described above.

Quercetin glycosides are said to be effective for the treatment of capillary bleeding and various bleedings, and they are said to have an antioxidant action. The quercetin glycosides increase blood pressure. It protects peripheral blood vessels against the increased circulation of blood and body fluids. It also affects the retention of osmotic pressure in body fluids and electrolyte balance such as acid-alkali equilibrium, and is a physiological regulator such as stimulatory transmission of muscle nerves. At least one of calcium ion, magnesium ion, and zinc ion, which is a divalent metal ion
By containing seeds, the recovery of biological functions is promoted.In addition, by containing licorice extract, the active ingredient glycyrrhizin promotes metabolism of various substances in the liver and alleviates the burden. In addition, it is said that it suppresses various disorders by acting on liver damage suppression and microsomal metabolic enzymes, or cell membranes, and that glucuronic acid produced by decomposition of glycyrrhizin in the body forms a conjugate with a toxin. And the like, the detoxification action is expressed, the metabolism is promoted, the detoxification action and the liver function are improved and the protective action is exhibited, and the secretion of bile is promoted.

By improving and maintaining the physical condition by the synergistic action of these ingredients,
By improving the feeling of fatigue, malaise, and feeling of collapse, and by providing it as an internal solution which is an aqueous solution, it has the effect of safely and easily drinking anytime, anywhere and maintaining a healthy condition.

When the liquid preparation for internal use of the present invention further contains vitamin C and / or an organic acid, the vitamin C
Not only enhances the absorption and stability of quercetin glycosides, but also interacts with quercetin glycosides to exert a synergistic effect on the digestive and circulatory organs, which results in the metabolism of substances. It is promoted to further improve tiredness, malaise, discomfort, and the like, and by containing the organic acid, quercetin glycosides and vitamin C can be further stabilized and cell activation can be achieved. In particular, the use of citric acid has the effect of decomposing lactic acid, pyrogluconic acid and the like in the body to prevent acidification of blood.

As described above, surprisingly, in the liquid preparation for internal use of the present invention, the amount of each component is at least the feeling of fatigue,
Fatigue, discomfort, eye strain, etc. are alleviated, and fatigue,
It has the effect of preventing and preventing fatigue, weakness, and eye strain.

As described above, the liquid preparation for internal use of the present invention is a highly safe drink, can be easily taken at any time, and is extremely useful in maintaining a healthy state in terms of the combined action and effect of the components. is there.

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Claims (8)

[Claims] 1. A liquid agent which supplements a human body with a shortage of metal ions when drinking by a person and promotes a metabolic function in licorice to maintain a healthy body condition. The liquid agent is a glycoside of quercetin. An internal liquid preparation containing a quercetin glycoside, which comprises divalent metal ions and a licorice extract as essential components. 2. An internal-use liquid preparation containing a quercetin glycoside according to claim 1, wherein the quercetin glycoside is water-soluble. 3. A liquid preparation for internal use containing the quercetin glycoside according to claim 1 or 2, wherein the quercetin glycoside is included in cyclodextrin. 4. The divalent metal ion is calcium ion,
At least one of magnesium ion or zinc ion
An internal solution containing the quercetin glycoside according to any one of claims 1 to 3, which is a seed. 5. A liquid preparation for internal use containing the quercetin glycoside according to any one of claims 1 to 4, wherein the licorice extract contains glycyrrhizin. 6. A liquid preparation for internal use containing the quercetin glycoside according to any one of claims 1 to 5, wherein the licorice extract is included in cyclodextrin. 7. An internal solution containing the quercetin glycoside according to any one of claims 1 to 6, wherein the internal solution containing quercetin glycoside contains vitamin C and / or an organic acid. . 8. The liquid preparation for internal use containing the quercetin glycoside according to claim 7, wherein the organic acid is at least one selected from citric acid, malic acid, and tartar liquor.