JPH07256122A - Tip for pipetter - Google Patents

Abstract

PURPOSE:To smoothly sample the liquid in a hermetic container or to smoothly add the liquid into this hermetic container. CONSTITUTION:The tip 3 of a pipetter 1 is pricked into a rubber plug 12 in the central part of the cap of a vial bottle 10. A hole is then formed in this rubber plug 12 by the tip 3 and a spacing is formed between the inner peripheral part of this hole and a rugged part 5 formed on the outer peripheral surface of the tip 3 and, therefore, gas flows through this spacing into the vial bottle 10, thereby preventing the inside from the vial bottle 10 from attaining a reduced pressure state. Then, specimen 11 is sucked into the pipetter 1 without resistance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pipettor tip used when collecting or adding a liquid in a closed bottle.

[0002]

2. Description of the Related Art In a sterilization test and various analytical tests for quality assurance of pharmaceutical products, when a sample in a vial is a liquid, it is collected and inoculated into a medium, and the sample is a powder. In some cases, the solution is added and dissolved, and then the medium is inoculated. And the operation of the liquid to the vial, after opening the stopper, the liquid is sucked or supplied by a pipettor, but when applied to an automatic sterility test device, a mechanism for opening the stopper is required separately, In addition, opening the stopper increases the chances that external impurities will be mixed in.

Therefore, in the vial bottle, a stopper is made of rubber, and the rubber stopper is pierced with an injection needle or a tip of a pipettor to suck the liquid inside or supply the liquid to the inside. . However, in this case, the hole formed in the rubber stopper by the injection needle or the tip is in close contact with the outer peripheral surface of the injection needle or the tip, so when sucking the liquid, the inside of the bottle is depressurized, and the liquid gradually becomes difficult to collect, The liquid to be collected remains in the bottle, and when supplying the liquid, the inside of the bottle is gradually pressurized, and the liquid remains in the injection needle or the tip. U

In order to eliminate this disadvantage, an injection needle other than the injection needle or tip for sucking or supplying liquid is pierced at the same time, and external pressure is introduced into the bottle by this injection needle or the inside of the bottle is introduced. It is firmly practiced to operate while discharging the pressure to the outside.

[0005]

As described above, by inserting another injection needle in addition to the injection needle or tip for sucking or supplying liquid, the inside of the lid can be opened without opening the lid. The liquid can be collected without leaving any liquid, but an injection needle must always be prepared in addition to the tip, which is a large pipette device. Further, in the case of the automatic sterility test apparatus, the injection needle and the tip must be disposable in order to ensure the sterility of each sample, and not only the injection needle itself is dangerous, but also the apparatus becomes complicated.

[0006]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention provides a concavo-convex portion along the axial direction in a predetermined range on the outer peripheral surface of a tip integrally or replaceably provided at the tip of a pipetter. Formed.

[0007]

When the tip is inserted into the stopper made of an elastic material such as rubber and the liquid inside is aspirated or supplied, between the uneven portion formed on the outer periphery of the tip and the inner periphery of the hole formed by inserting the tip. A gap is formed in.

[0008]

Embodiments of the present invention will be described below with reference to the accompanying drawings. Here, FIG. 1 is an overall view of a pipettor equipped with a tip according to the present invention, FIG. 2 is an enlarged cross-sectional view of a tip penetrating a rubber coating portion, and FIG. 3 is a cross-sectional view taken along line AA of FIG. is there.

The pipetter 1 is composed of a main body portion 2 and a tip 3. The main body portion 2 and the tip 3 are integrally molded using a material such as polypropylene, or they are separately manufactured, and a large number of tips 3 are formed in the main body. It may be detachable from the portion 2.

An operation knob 4 is provided on the main body portion 2, and an uneven portion 5 is formed in a predetermined area 3a of the outer peripheral surface of the tip 3 along the axial direction. This uneven portion 5 is shown in FIG.
As shown in FIG. 3, the convex ridge 5a has a triangular cross section, and the groove 5b has a triangular cross section. With the triangular cross section as described above, it becomes possible to make a hole in the rubber coating or the like with a small force as described later.

On the other hand, in FIG. 1, reference numeral 10 is a vial, and a sample 11 is put in the vial 10, and a stopper 12 made of an elastic material such as rubber is fitted into the opening of the vial 10. It is attached and is hermetically sealed with an aluminum material 13 around the same.

In order to collect the sample (liquid) 11 in the vial 10 with the pipettor 1, the tip 3 of the pipettor 1 is pierced into the stopper 12 of the vial 10 as shown in FIG. As shown in FIG. 3, the tip 3 forms a hole 14 in the plug 12,
A gap 15 is formed between the inner peripheral portion 4 and the concave-convex portion 5 formed in the predetermined range 3 a of the chip 3. Incidentally, the plug 12 may be preliminarily cut in a cross shape or the like so that the tip 3 can be easily pierced.

In this state, when the sample 11 in the vial bottle 10 is sucked by the pipettor 1, the sucked sample 1
The gas corresponding to the volume of 1 is prevented from flowing into the vial container 10 through the gap 15 and reducing the pressure inside the vial container 10. Therefore, the specimen 11 is sucked into the pipetter 1 without resistance.

In the embodiments, the case where the sample is sucked from the vial bottle has been described, but the pipettor tip according to the present invention is not limited to the vial bottle, and a hole is formed in a part of the sealed container. It can be widely applied when taking out the liquid inside. Furthermore, when the sample is a powder, the liquid is supplied into the vial to dissolve it, but in this case, the pressure inside the vial escapes from the gap 15,
Allows smooth liquid supply.

[0015]

As described above, according to the present invention,
As the shape of the pipettor tip, since an uneven portion along the axial direction was formed in a predetermined range of the outer peripheral surface, the tip was inserted into the lid of a sealed container such as a vial bottle to suck or suck the liquid inside. When supplying the liquid, since a gap is formed between the uneven portion formed on the outer periphery of the chip and the inner periphery of the hole formed by inserting the chip, the inside of the container is not depressurized or pressurized, When the liquid inside is collected, the liquid can be collected thoroughly, and when the liquid is supplied to the inside, the liquid does not remain in the chip.

[Brief description of drawings]

FIG. 1 is an overall view of a pipettor equipped with a tip according to the present invention.

FIG. 2 is an enlarged cross-sectional view of a chip penetrating a rubber coating part.

FIG. 3 is a sectional view taken along line AA of FIG.

[Explanation of symbols]

1 ... pipettor, 2 ... pipetter body, 3 ... chip, 5
... concavo-convex portion, 5a ... ridge, 5b ... concave groove, 10 ... vial bottle, 11 ... specimen, 12 ... rubber stopper, 14 ... hole, 15 ... gap.

Claims (1)

[Claims] 1. A pipette integrally or replaceably provided at the tip of the pipettor, wherein an uneven portion along the axial direction is formed in a predetermined range on the outer peripheral surface of the pipette. For chips.