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JPH07274977A - Extraction of useful plant essence, plant essence obtained by the extraction and skin-improving product containing the same essence as the active component - Google Patents

Extraction of useful plant essence, plant essence obtained by the extraction and skin-improving product containing the same essence as the active component

Info

Publication number
JPH07274977A
JPH07274977A JP6075199A JP7519994A JPH07274977A JP H07274977 A JPH07274977 A JP H07274977A JP 6075199 A JP6075199 A JP 6075199A JP 7519994 A JP7519994 A JP 7519994A JP H07274977 A JPH07274977 A JP H07274977A
Authority
JP
Japan
Prior art keywords
skin
plant
plant extract
improvement
improving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6075199A
Other languages
Japanese (ja)
Inventor
Jiyuue Mizutani
寿右衛 水渓
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shikoku Research Institute Inc
Original Assignee
Shikoku Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shikoku Research Institute Inc filed Critical Shikoku Research Institute Inc
Priority to JP6075199A priority Critical patent/JPH07274977A/en
Publication of JPH07274977A publication Critical patent/JPH07274977A/en
Pending legal-status Critical Current

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  • Detergent Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PURPOSE:To provide a method for extracting the active components of a useful plant for improvement of the skin by a bioreaction and a product for improvement of the skin containing the resultant extracted plant essence. CONSTITUTION:Extraction of a plant essence is carried out by adding one or more substances selected from an amylase, a protease, an Aspergillus oryzae and a polysaccharide decomposition microorganism and allowing them to act on one or more kinds of plants selected from ginseng, Houttuynia cordata, aloe, leaves of Japanese medlar, leaves of peach, Chinese matrimony vine, peony and garlic respectively having an effect for improvement of the skin. The product for improvement of the skin, e.g. a skin-care cosmetic, a bathing agent, a body shampoo, a liniment for improvement of dermal diseases or a hair tonic respectively containing the plant essence as the active component can be obtained by adding one or more substances selected from an yeast, a lactobacillus and a lipase after or during the course of the above-mentioned reaction, allowing them to act thereon and extracting the plant essence.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は、皮膚の改善効果のある
朝鮮人参、どくだみ、アロエ、びわの葉、桃の葉、ク
コ、芍薬、大蒜の植物エキス抽出方法及び該抽出方法に
より得られた植物エキス並びに該植物エキスを含有有効
成分とする皮膚改善用品に関するものである。
FIELD OF THE INVENTION The present invention provides a method for extracting a plant extract of ginseng, dolphin, aloe, loquat leaf, peach leaf, wolfberry, peony root, and ginger, which has a skin-improving effect, and a method for extracting the same. The present invention relates to a plant extract and a skin improving product containing the plant extract as an active ingredient.

【0002】[0002]

【従来の技術】朝鮮人参、どくだみ、アロエ、びわの
葉、桃の葉、クコ、芍薬、大蒜の植物には肌をしっと
り、艶やかにする効果があることが従来から知られてお
り、美容の目的でこれらの植物を煮だした液を肌に塗布
したり、浴湯に入れたりして使用することが行なわれて
来た。
2. Description of the Related Art It has been conventionally known that ginseng, dokudomi, aloe, loquat leaves, peach leaves, wolfberry, peony, and garlic plants have a moisturizing and radiant effect on the skin, For the purpose of beauty, it has been practiced to apply a liquid obtained by boiling these plants to the skin or to use it by putting it in a bath water.

【0003】また、この皮膚改善効果に着目して、これ
らの植物から煮だした液を含有する化粧水や入浴剤等が
商品化された事例も一部ある。
In addition, paying attention to the skin improving effect, there are some cases in which lotions and bath salts containing the liquid boiled from these plants have been commercialized.

【0004】[0004]

【発明が解決しようとする課題】従来より行われてきた
有効成分を取り出す方法としての煮だしの方法では、有
効成分の抽出が水や熱湯に溶出する分にとどまり、ま
た、有効成分が溶出しても澱分、高分子の多糖類、蛋白
質等と結合した形で存在するため、そのままの形では皮
膚の改善効果が顕著に現われないという問題があった。
In the conventional simmering method as a method for extracting the active ingredient, the extraction of the active ingredient is limited to elution in water or boiling water, and the active ingredient is eluted. However, since it exists in the form of being bound to starch, high-molecular polysaccharides, proteins, etc., there is a problem that the skin-improving effect does not appear remarkably in the intact form.

【0005】本発明は、従来利用できなかった有効成分
をもバイオ反応により澱分、多糖類、蛋白質等より分解
して植物エキスを抽出する方法及び該方法により得られ
た植物エキス並びに該植物エキスを含有有効成分とする
皮膚改善用品を提供することにある。
The present invention relates to a method for extracting a plant extract by decomposing an active ingredient, which has not been conventionally available, from a starch, a polysaccharide, a protein or the like by a bioreaction, a plant extract obtained by the method, and the plant extract. It is intended to provide a skin-improving product containing as an active ingredient.

【0006】[0006]

【課題を解決するための手段】上記の目的を達成するた
めに、請求項1〜2に記載された発明は、朝鮮人参、ど
くだみ、アロエ、びわの葉、桃の葉、クコ、芍薬、大蒜
の少なくとも一つの植物に澱分分解酵素、蛋白質分解酵
素、麹菌、多糖類分解微生物のうち少なくとも一つを加
え反応させて植物エキスを抽出する方法としている。ま
たさらに、該反応の過程中または反応後に、酵母、乳酸
菌および脂肪分解酵素のうち少なくとも一つを加え反応
させて植物エキスを抽出させる方法としている。
[Means for Solving the Problems] In order to achieve the above object, the inventions described in claims 1 and 2 are ginseng, dodami, aloe, loquat leaf, peach leaf, wolfberry, peony, and garlic. At least one of a starch-degrading enzyme, a protein-degrading enzyme, a koji mold, and a polysaccharide-degrading microorganism is added to at least one of the plants and reacted to extract a plant extract. Further, during the reaction process or after the reaction, at least one of yeast, lactic acid bacterium and lipolytic enzyme is added and reacted to extract a plant extract.

【0007】請求項3に記載された発明は、朝鮮人参、
どくだみ、アロエ、びわの葉、桃の葉、クコ、芍薬、大
蒜のうち少なくとも一つの植物に澱粉分解酵素、蛋白分
解酵素、麹菌、多糖類分解微生物のうち少なくとも一つ
を加え反応させて抽出された植物エキス。またさらに、
該反応の過程中または反応後に、酵母、乳酸菌及び脂肪
分解酵素のうち少なくとも一つを加え反応させ抽出させ
ることにより植物エキスとしている。
The invention described in claim 3 is a ginseng,
Extracted by adding at least one of starch degrading enzyme, proteolytic enzyme, koji mold, and polysaccharide-degrading microorganism to at least one plant of Dodami, aloe, loquat leaf, peach leaf, wolfberry, peony, and garlic. Plant extract. Furthermore,
During the reaction process or after the reaction, at least one of yeast, lactic acid bacterium and lipolytic enzyme is added and reacted to obtain a plant extract.

【0008】請求項4〜7に記載された発明は、請求項
3の植物エキスを有効成分として含有させた基礎化粧
品、入浴剤、石鹸またはボディシャンプ−、皮膚疾患改
善用塗布剤である皮膚改善用品としている。
The inventions described in claims 4 to 7 are basic cosmetics, bath agents, soaps or body shampoos containing the plant extract of claim 3 as an active ingredient, and skin improvement which is an application agent for improving skin diseases. It is used as an article.

【0009】請求項8に記載された発明は、請求項3の
植物エキスのうち、どくだみ、びわの葉の少なくとも一
つを原料とした植物エキスを有効成分として含有させた
育毛剤または育毛用ヘアシャンプ−である皮膚改善用品
としている。
The invention described in claim 8 is, in the plant extract of claim 3, a hair-growing agent or hair-growing hair containing as an active ingredient a plant extract derived from at least one of Dodoma and loquat leaves. It is used as a skin improvement product that is a shampoo.

【0010】[0010]

【作用】 本発明による植物エキスの抽出方法では、前
記有用植物に澱分分解酵素、蛋白質分解酵素、麹菌等を
添加し、密閉反応容器内等でバイオ反応を起こさせる
と、高分子構造の成分を低分子の糖類やアミノ酸等に分
解し、この過程で澱分、多糖類、蛋白質等と結合したり
これらの構成要素の一部となっていた有効成分が分離あ
るいは生成して溶出される。
In the method for extracting a plant extract according to the present invention, a starch-degrading enzyme, a proteolytic enzyme, a koji mold or the like is added to the useful plant, and a bioreaction is caused in a closed reaction vessel or the like to obtain a component having a polymer structure. Is decomposed into low-molecular-weight sugars and amino acids, and in this process, active ingredients that bind to starch, polysaccharides, proteins, etc., or become a part of these constituents are separated or produced and eluted.

【0011】また、酵素や麹菌のほかに、更に、酵母あ
るいは乳酸菌も加えて発酵させることにより、更に、異
なった有効成分を抽出させることができる。
Further, in addition to the enzyme and the koji mold, yeast or lactic acid bacterium is further added for fermentation, whereby different active ingredients can be further extracted.

【0012】よって、本発明による植物エキスを含有す
る基礎化粧品、入浴剤、ボディシャンプ−、皮膚疾患塗
布剤の皮膚改善用品は従来の植物の煮だし液を用いたも
のに比べ、はるかに皮膚改善効果の高いものとなる。
Therefore, the skin-improving products such as the basic cosmetics, bath salts, body shampoos, and skin disease-applying agents containing the plant extract according to the present invention are far more effective in improving skin than those using the conventional plant brewing solution. It will be highly effective.

【0013】更に、植物エキスのうち、どくだみ、びわ
の葉の少なくとも一つを原料とする植物エキスを含有さ
せることにより、育毛の働きが強くなる。
Further, among the plant extracts, by incorporating a plant extract containing at least one of Dodogami and loquat leaves as a raw material, the function of hair growth is enhanced.

【0014】[0014]

【発明の効果】本発明は、以上説明したような抽出エキ
スとなっているので、以下に記載されるような効果を奏
する。
EFFECTS OF THE INVENTION Since the present invention is the extract as described above, it has the following effects.

【0015】請求項1〜3に記載された発明によれば、
前記皮膚改善効果のある植物に澱粉分解酵素、蛋白質分
解酵素、麹菌等によるバイオ反応により抽出する方法と
しているので、従来の煮だしでは限度のある澱粉や多糖
類に結合している有効成分の分離溶出が可能となり、は
るかに多くのかつ有効な植物エキスが得られる。
According to the invention described in claims 1 to 3,
Since the method of extracting the plant having a skin-improving effect by a bioreaction such as starch degrading enzyme, proteolytic enzyme, or Aspergillus oryzae, separation of the active ingredient bound to starch or polysaccharides, which is limited by conventional simmering, is performed. Elution is possible and much more effective plant extract is obtained.

【0016】また、請求項4〜7に記載された発明によ
れば、抽出した植物エキスを肌に塗布した結果、キメが
細かくなり張りや艶がでて皮膚の改良効果が大きいの
で、植物エキスを含有させることにより皮膚改善効果の
大きい基礎化粧品、入浴剤、石鹸及びボディシャンプ−
等を作ることができる。
According to the invention described in claims 4 to 7, the extracted plant extract is applied to the skin, and as a result, the texture becomes fine and the texture is fine and glossy, and the skin improving effect is great. Basic cosmetics, bath salts, soaps and body shampoos that have a large skin-improving effect by containing
Etc. can be made.

【0017】更に、皮膚の湿疹部に塗布すると症状の改
善がみられ、皮膚の活力機能を高め湿疹等を治癒させる
効果も確認でき、皮膚疾患改善塗布剤を作ることができ
る。
Further, when it is applied to the eczema part of the skin, the symptoms are improved, the effect of enhancing the vital function of the skin and healing of eczema and the like can be confirmed, and a skin disease improving application agent can be prepared.

【0018】またさらに、請求項8に記載された発明に
よれば、どくだみ、びわの葉より抽出した植物エキスを
頭禿部に塗って育毛効果も確認でき、育毛剤や育毛用ヘ
アシャンプ−を作ることができる。
Furthermore, according to the invention described in claim 8, the hair growth effect can be confirmed by applying the plant extract extracted from the leaves of Dodoma and loquat to the bald areas of the hair. Can be made.

【0019】[0019]

【実施例】朝鮮人参及びびわの葉を細かく砕き加熱水蒸
気に通した後、三倍重量の水を加えて45℃まで加熱す
る。これに澱粉分解酵素であるアミラ−ゼと蛋白質分解
酵素であるプロテア−ゼと米麹を添加し、密閉容器の中
で45℃の温度条件で三日間据え置く。
[Examples] Ginseng and loquat leaves are finely crushed and passed through heated steam, and then triple weight of water is added and heated to 45 ° C. To this, amylase which is a starch degrading enzyme, protease which is a proteolytic enzyme and rice koji are added, and the mixture is left to stand in a closed container at a temperature of 45 ° C. for 3 days.

【0020】その間に、分解して泥状になっている朝鮮
人参とびわの葉の混合液を濾過装置を通して濾過し透明
な朝鮮人参及びびわの葉混合エキスを得る。
In the meantime, the decomposed mud-like mixture of ginseng and loquat leaves is filtered through a filtration device to obtain a transparent ginseng and loquat leaf mixed extract.

【0021】この朝鮮人参及びびわの葉混合エキスを4
0代の女性8人及び30代の女性8人をモニタとして朝
晩2回顔に塗布し2週間後の素肌の状態を肉眼及びマイ
クロスコ−プの50倍観察を行なったところ、40代の
女性では8人中6人に、30代の女性では8人中5人に
顕著な肌の改善効果が認められた。
4 ginseng and loquat leaf mixed extract
Eight women in their 0's and eight women in their thirties were applied to the face twice a day as monitors, and the skin condition after 2 weeks was observed with the naked eye and microscopic microscope at 50 times magnification. In 6 out of 8, 5 out of 8 in women in their thirties showed remarkable skin improving effects.

【0022】具体的な改善効果としては、肌に張りや艶
がでてきた事例が多くまた、皮丘が小さく低くなりキメ
が細かくなっている様子がマイクロスコ−プの観察で多
く認められた。
As a concrete improvement effect, there are many cases where the skin is tense or shiny, and it is observed by microscopic observation that the cuticles are small and the texture is fine. .

【0023】また、この朝鮮人参及びびわの葉混合エキ
スを湿疹のある女性6人に毎日2回塗布したところ、6
人中4人に2〜3日目から症状が良くなり3人は6〜7
日後に完治し、肌の改善に加え皮膚の活力、機能をも高
めて湿疹等を治癒させる効果のあることも確認できた。
Further, when the ginseng and loquat leaf mixed extract was applied twice a day to 6 women with eczema, 6
Symptoms improved from day 2 to day 3 in 4 out of 6 people 6 to 7
It was confirmed that it was completely cured after a day, and in addition to improving the skin, it also has the effect of enhancing the vitality and function of the skin and healing eczema and the like.

【0024】なお、従来から行なわれている朝鮮人参及
びびわの葉の煮だし液について比較モニタ試験を行なっ
たが、2週間後では肌の改善は殆ど認められず、5週間
後経過した時点で8人中3人に微弱な改善効果が認めら
れるに過ぎなかった。
A comparative monitor test was carried out on the conventional ginseng and loquat leaf simmering liquid, but almost no improvement in the skin was observed after 2 weeks, and after 5 weeks had passed. Only 3 out of 8 had a slight improvement effect.

【0025】なお、本実施例では、朝鮮人参及びびわの
葉への加水量を300%とし、加熱温度を45℃として
反応させたが、通常、加水量は50〜400%の範囲が
適当であり、また、バイオ反応の温度条件は用いる酵素
や微生物の種類に応じて10〜80℃の範囲の中から選
定するのが適切である。
In this example, the amount of water added to ginseng and loquat leaves was set to 300% and the heating temperature was set to 45 ° C., but the amount of water added was usually in the range of 50 to 400%. In addition, the temperature condition of the bioreaction is appropriately selected from the range of 10 to 80 ° C. according to the type of enzyme or microorganism used.

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 FI 技術表示箇所 C07G 17/00 Z C11D 9/38 C12P 1/02 Z 7417−4B //(C12P 1/02 C12R 1:645) ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification code Internal reference number FI Technical display location C07G 17/00 Z C11D 9/38 C12P 1/02 Z 7417-4B // (C12P 1/02 C12R 1: 645)

Claims (8)

【特許請求の範囲】[Claims] 【請求項1】 皮膚改善効果のある朝鮮人参、どくだ
み、アロエ、びわの葉、桃の葉、クコ、芍薬、大蒜の少
なくとも一つの植物に澱分分解酵素、蛋白質分解酵素、
麹菌、多糖類分解微生物のうち少なくとも一つを加えて
反応させ植物エキスを抽出する方法。
1. At least one plant of ginseng, dokudomi, aloe, loquat leaf, peach leaf, wolfberry, peony, and garlic, which have a skin-improving effect, on at least one plant, a degrading enzyme, a proteolytic enzyme,
A method for extracting a plant extract by adding at least one of Aspergillus or a microorganism degrading a polysaccharide.
【請求項2】 請求項1の反応過程中または反応後に、
さらに酵母、乳酸菌および脂肪分解酵素のうち少なくと
も一つを加え反応させ植物エキスを抽出させる方法。
2. During or after the reaction according to claim 1,
Further, at least one of yeast, lactic acid bacterium and lipolytic enzyme is added and reacted to extract a plant extract.
【請求項3】 請求項1または請求項2の抽出方法によ
り得られた植物エキス。
3. A plant extract obtained by the extraction method according to claim 1 or 2.
【請求項4】 請求項3の植物エキスを含有有効成分と
する基礎化粧品である皮膚改善用品。
4. A skin improving article which is a basic cosmetic containing the plant extract of claim 3 as an active ingredient.
【請求項5】 請求項3の植物エキスを含有有効成分と
する入浴剤である皮膚改善用品。
5. A skin-improving article which is a bath agent containing the plant extract according to claim 3 as an active ingredient.
【請求項6】 請求項3の植物エキスを含有有効成分と
する石鹸またはボディシャンプ−である皮膚改善用品。
6. A skin improving article which is a soap or body shampoo containing the plant extract of claim 3 as an active ingredient.
【請求項7】 請求項3の植物エキスを含有有効成分と
する皮膚疾患改善用塗布剤である皮膚改善用品。
7. A skin-improving article which is a skin disease-improving coating agent containing the plant extract according to claim 3 as an active ingredient.
【請求項8】 請求項3の植物エキスのうち、どくだ
み、びわの葉の少なくとも一つを原料とする植物エキス
を含有有効成分とする育毛剤または育毛用ヘアシャンプ
−である皮膚改善用品。
8. A skin-improving article which is a hair-growing agent or hair shampoo containing a plant extract containing at least one of Dodoma and loquat leaves as a raw material, among the plant extracts according to claim 3.
JP6075199A 1994-04-14 1994-04-14 Extraction of useful plant essence, plant essence obtained by the extraction and skin-improving product containing the same essence as the active component Pending JPH07274977A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6075199A JPH07274977A (en) 1994-04-14 1994-04-14 Extraction of useful plant essence, plant essence obtained by the extraction and skin-improving product containing the same essence as the active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6075199A JPH07274977A (en) 1994-04-14 1994-04-14 Extraction of useful plant essence, plant essence obtained by the extraction and skin-improving product containing the same essence as the active component

Publications (1)

Publication Number Publication Date
JPH07274977A true JPH07274977A (en) 1995-10-24

Family

ID=13569296

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6075199A Pending JPH07274977A (en) 1994-04-14 1994-04-14 Extraction of useful plant essence, plant essence obtained by the extraction and skin-improving product containing the same essence as the active component

Country Status (1)

Country Link
JP (1) JPH07274977A (en)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037635A1 (en) * 1996-04-04 1997-10-16 Shiseido Company, Ltd. External preparations for the amelioration and prevention of chapped skin
JPH1017439A (en) * 1996-07-02 1998-01-20 Hoyu Co Ltd Hair growing and restoring agent
JPH1017440A (en) * 1996-07-02 1998-01-20 Hoyu Co Ltd Hair growing and restoring agent
JPH10182474A (en) * 1996-12-25 1998-07-07 Takeo Wakaguwa Agent for preventing prickly heat, sore, eczema and itching
EP0815838A3 (en) * 1996-06-28 1999-11-10 Shiseido Company, Ltd. External skin treatment composition
JP2001137611A (en) * 1999-11-10 2001-05-22 Takashi Miyagawa Extraction method of cedar leaf extract
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WO1997037635A1 (en) * 1996-04-04 1997-10-16 Shiseido Company, Ltd. External preparations for the amelioration and prevention of chapped skin
EP0815838A3 (en) * 1996-06-28 1999-11-10 Shiseido Company, Ltd. External skin treatment composition
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WO2003101417A1 (en) * 2002-06-03 2003-12-11 Uni-Charm Corporation Cleaning agent composition for wiping
JP2004196664A (en) * 2002-12-16 2004-07-15 Yakult Honsha Co Ltd Moisturizer and cosmetics containing it
JPWO2005000319A1 (en) * 2003-06-26 2006-11-09 サントリー株式会社 Composition for external use
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JP2005298489A (en) * 2004-03-15 2005-10-27 Kyoei Kagaku Kogyo Kk Cosmetics
JP2010043088A (en) * 2004-03-15 2010-02-25 Kyoei Kagaku Kogyo Kk Cosmetic product
JP2006117644A (en) * 2004-09-24 2006-05-11 Toyo Shinyaku:Kk Composition containing kudzu flower
JP2006104129A (en) * 2004-10-06 2006-04-20 Kyoei Kagaku Kogyo Kk Cosmetics
JP2006219434A (en) * 2005-02-10 2006-08-24 Kyoei Kagaku Kogyo Kk Cosmetics
JP2007145790A (en) * 2005-03-07 2007-06-14 Kyoei Kagaku Kogyo Kk Cosmetic
JP2009179643A (en) * 2005-03-07 2009-08-13 Kyoei Kagaku Kogyo Kk Cosmetic
WO2006111163A1 (en) * 2005-04-21 2006-10-26 Novozymes A/S Plant extraction process
JP2006347925A (en) * 2005-06-14 2006-12-28 Kyoei Kagaku Kogyo Kk Fermented plant and cosmetics containing the same
US7291340B2 (en) 2005-12-29 2007-11-06 Elc Management Llc Extracts from black yeast for whitening skin
US7862822B2 (en) 2007-09-25 2011-01-04 Elc Management Llc Extracts from black yeast for whitening skin
JP2010077041A (en) * 2008-09-25 2010-04-08 Kao Corp Bleaching ingredient and skin cosmetic
JP2014028781A (en) * 2012-07-31 2014-02-13 Zenshin:Kk Producing method of cosmetic and cosmetic produced with the producing method
JP2014162738A (en) * 2013-02-22 2014-09-08 Kracie Home Products Ltd Cosmetics and perspiration promoter
CN103355664A (en) * 2013-04-01 2013-10-23 张家界金鲵生物工程股份有限公司 Giant salamander bone containing capsules and preparation method thereof
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CN103554284A (en) * 2013-10-11 2014-02-05 青岛农业大学 Extraction and separation process for peony stamen polysaccharide
CN104013561A (en) * 2014-05-28 2014-09-03 皖南医学院 Supple moistening water-locking mild nourishing shampoo paste and preparation method thereof
JP2017177045A (en) * 2016-03-31 2017-10-05 丸善製薬株式会社 Residual chlorine scavenger, bath preparation composition, and skin cosmetic
JP2021031466A (en) * 2019-08-28 2021-03-01 浩市 小寺 Hair dyeing method

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