JPH0761929B2 - Cosmetic containing derivative of plant polypeptide - Google Patents

Description

TECHNICAL FIELD The present invention relates to a novel cosmetic, and more specifically, it has extremely good adsorptivity to hair and improves softness, gloss and smoothness of hair. The present invention relates to an excellent cosmetic that can be produced and has no unpleasant odor.

(Prior Art) Quaternary ammonium derivatives are used for cosmetics, especially hair rinses, and have excellent adsorbability to hair, flexibility of hair, luster,
It has the effect of improving smoothness.

Among them, stearyl dimethyl benzyl ammonium chloride, stearyl trimethyl ammonium chloride, etc. have been used for a long time.

Recently, in order to further improve the effect, a hydrolyzate of animal protein such as collagen and keratin, which is converted to a quaternary ammonium, has been proposed.

Specifically, for example, in JP-A-60-243010,
Disclosed is a hair protecting agent comprising a quaternary trimethylammonium derivative polypeptide obtained by reacting 3-chloro-2-hydroxypropyltrimethylammonium chloride with an animal protein-derived polypeptide such as collagen, keratin, and elastin. .

On the other hand, as a vegetable protein derivative, pages 171 to 172 of Fragrance Journal 75 (1985) disclose water-soluble hydrolyzed soybean protein obtained from soybean protein as a raw material for cosmetics.

(Problems to be Solved by the Invention) However, in the quaternary trimethylammonium derivative polypeptide disclosed in the above-mentioned JP-A-60-243010, the adsorption to hair is certainly greater than that of a peptide that is not quaternized. However, it has a problem that it does not have sufficiently excellent adsorptivity.

Moreover, the quaternary ammonium derivatives of the polypeptide obtained by hydrolyzing such animal proteins as collagen and keratin have different animal odors to different extents, but these are especially consumed recently. There is also a problem in that it is not sufficient as a raw material for cosmetics because the tendency for people to not add a fragrance to cosmetics tends to be disliked.

On the other hand, water-soluble hydrolyzed soybean protein obtained from soybean protein is an excellent cosmetic raw material without animal odor,
There is a problem that the adsorptivity to hair is not sufficient.

Therefore, in the industry, cosmetics that tend to dislike the addition of fragrances can be suitably blended without imparting an unpleasant odor such as animal odor, and the adsorbability to hair is extremely good, and the flexibility and smoothness are excellent. There has been a demand for the creation of a cosmetic material that can improve the properties and glossiness.

(Means for Solving the Problems) In the present invention, 3-chloro-2-hydroxypropyltrimethylammonium salt is added to an aqueous solution of a water-soluble polypeptide obtained by hydrolyzing a substance obtained by concentrating a protein of a natural plant seed. By providing a cosmetic characterized by containing a quaternary trimethylammonium derivative of a plant polypeptide obtained by the reaction, the above-mentioned conventional problems are solved.

(Structure of Invention) Hereinafter, the structure of a cosmetic containing the derivative of the plant polypeptide according to the present invention will be described in detail.

In the present invention, a water-soluble polypeptide obtained by hydrolyzing a substance obtained by concentrating a protein of a natural plant seed is used as a starting material.

As the vegetable protein, one having a high protein concentration is also preferable.

However, the content of soybean, which is one of the plant seeds containing the highest concentration of protein, is about 40%.

The residue obtained by squeezing or extracting oil and fat from soybean is a seed protein concentrate in terms of protein.

In addition, wheat has a lower protein content and a higher starch content.

Gradually washing the strong flour with water leaves the starch, leaving behind gluten.

This gluten has a high protein concentration and corresponds to the seed protein concentrate according to the present invention.

In this way, the oil or fat is squeezed or extracted from the plant seed, and the starch, sugar, etc. removed by water treatment, microbial treatment, etc. is the concentrate of the seed protein of the present invention, which is largely different from that of the animal protein raw material That is the difference.

Examples of plant seeds preferably used in the present invention include soybean, wheat, corn, almond and the like.

Next is hydrolysis, which is roughly divided into three methods.

That is, hydrolysis with oxygen, acid, and alkali.

In the case of hydrolysis with oxygen, the oxygen that can be used belongs to proteases, and may be pepsin, papain, trypsin or of bacterial origin.

However, it is necessary to select pH and temperature conditions suitable for the oxygen during hydrolysis.

In the case of acid decomposition, hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid or the like can be used, and in the case of alkaline decomposition, sodium hydroxide, potassium hydroxide, sodium carbonate or the like can be used.

The hydrolysis of the present invention may be any of them.

The average molecular weight of the polypeptide after hydrolysis is 500 to 10,000
It may be 0, but more preferably 1,000 to 5,000.

In addition, a unit amino acid that has been decomposed may be mixed to some extent.

If the average molecular weight is too small, the effect when blended in cosmetics is small, and if it is too large, the water solubility deteriorates.

The thus obtained aqueous hydrolyzate solution is quaternized with ammonium to obtain the cosmetic of the present invention. Prior to the quaternization, a deionization treatment with an ion exchange resin, if necessary,
Concentrate, dilute, or decolorize and deodorize with activated carbon.

Quaternary ammonium conversion is carried out by reacting 3-chloro-2-hydroxypropyltrimethylammonium salt with a polypeptide.

This salt is not limited to the hydrochloride, but the water-soluble salt of ordinary hydrochloride is commercially available and can be preferably used.

The reaction is a reaction in which hydrogen chloride is produced from the hydrogen atom of the amino group of the polypeptide and the chlorine atom at the 3-position of 3-chloro-2-hydroxypropyltrimethylammonium salt,
It progresses if the 3-chloro-2-hydroxypropyltrimethylammonium salt is gradually added dropwise to 10 to 40% of the water solubility of the polypeptide while stirring at room temperature to 50 ° C.

At this time, the reaction solution must be kept alkaline with a pH of about 9 to 12.

In order to make it alkaline, it is necessary to add an alkali such as sodium hydroxide or potassium hydroxide.

The reaction proceeds almost completely if left for about 24 hours after the completion of dropping.

After the reaction, the solution is returned to almost neutral by using an acid such as hydrochloric acid, sulfuric acid, phosphoric acid, or by using an ion exchange resin.

An antiseptic agent may be added to this liquid to be used as a raw material for cosmetics as it is, or it may be dried and powdered by a method such as freeze-drying to be used as a raw material for cosmetics.

The cosmetic when the quaternary trimethylammonium derivative of the hydrolyzate of the natural plant seed protein thus produced is mixed with the cosmetic may be, for example, a hair rinse or a hair-like cosmetic such as cold perm solution, Further, it may be for skin such as lotion and cream emulsion.

The blending amount thereof is preferably 0.5 to 15% in terms of solid content.

However, when anionic surfactants are included in other compounded raw materials, water-insoluble precipitation may occur, so care must be taken when preparing the formulation.

(Example 1) 100 parts of defatted soybean flour for food was dispersed in 2,000 parts of water, and the pH was adjusted to 7.0 with sodium hydroxide.

Add 1 part cysteine and 1 part papain to this, and add 8
Hydrolyzed for hours.

During this time, the pH drops, so use sodium hydroxide every 2 hours.
It was adjusted to pH 7.

After hydrolysis, heating was performed at 70 ° C. for 30 minutes to lose oxygen activity.

After cooling, the mixture was filtered and the filtrate was concentrated under reduced pressure at 70 ° C.

At this time, a slight precipitate was generated, and therefore, re-filtration was performed.

The solid content concentration after re-filtration was 38%, and the average molecular weight of the polypeptide was 4,000 (1A solution).

Put 100 parts of this solution into a reaction vessel and stir at 40 ° C for 3
12 parts of a 50% aqueous solution of -chloro-2-hydroxypropyltrimethylammonium chloride was added dropwise over 20 minutes, and the pH after the reaction was adjusted to 10.0 to 11.0.

Then, stirring was continued at 40 ° C. for 6 hours, and pH was adjusted during that period.

Then, the stirring was stopped and the mixture was left at room temperature for 2 days.

The final pH was 10.1.

Hydrochloric acid and water are added to this solution and filtered to obtain a pH of 6.5 and a solid content concentration of 25.
It was adjusted to be% (1B solution).

(Example 2) Starch was removed from strong wheat flour for food by a water washing method to obtain gluten.

The gluten had a solid content of 32% and a water content of 68%, and the crude protein in the solid content was 76%.

20 parts of concentrated hydrochloric acid (35%) was added to 100 parts of this gluten, and hydrolysis was carried out at 80 ° C. for 5 hours while stirring.

After cooling, the mixture was filtered, neutralized with a weakly basic anion exchange resin, and concentrated to a solid content of 38% (2A solution).

The average molecular weight of the polypeptide in Solution 2A was 2,500.

This was converted to quaternary ammonium by the same method as in Example 1 to obtain a liquid having a solid content of 25% (2B liquid).

(Example 3) Collagen hydrolyzate (3A) having an average molecular weight of 4,000 and its quaternary ammonium compound (3B), and 1A, 1B, 2A,
Six types of 2B were each made into an aqueous solution so as to have a solid content of 2%, and the washed and dried human hair was treated for 5 minutes, and the state after washing and drying under the same conditions was examined.

(Example 4) Two types of hair rinses were produced by the following formulations.

When 10 and 10 were respectively used as rinses after washing hair, there was almost no difference in softness, smoothness and gloss after washing, but there was a slight animal odor. , Which was not recognized at all.

(Effects of the Invention) As described in detail above, the present invention uses 3-chloro-2-hydroxypropyl trimethyl in an aqueous solution of a water-soluble polypeptide obtained by hydrolyzing a substance obtained by concentrating proteins of natural plant seeds. Since the cosmetic composition is characterized by containing a quaternary trimethylammonium derivative of a plant polypeptide obtained by reacting an ammonium salt, the quaternary ammonium of animal protein is clear, as is clear from the results of the above test examples. The adsorption amount to hair is significantly higher than that of the compound, and not only when the molecular weight is the same, but when the molecular weight is small, the adsorption amount is similar to that of the quaternary ammonium compound of the animal protein having a large molecular weight, and the animal odor It has an excellent effect that it is a versatile cosmetic material without unpleasant odor.

Claims (1)

[Claims] 1. A plant obtained by reacting an aqueous solution of a water-soluble polypeptide obtained by hydrolyzing a substance obtained by concentrating a protein of a natural plant seed with 3-chloro-2-hydroxypropyltrimethylammonium salt. Sex polypeptide 4
A cosmetic containing a graded trimethylammonium derivative.