JPH09263527A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external uses for skins, improved in the dispensability of a hydrophobic powdery material by adding an anionic surfactant to a W/O emulsion preparation containing the hydrophobic powdery material. SOLUTION: This preparation for external uses for skins comprises a W/O emulsion preparation compounded with a hydrophobic powdery material (e.g. fine titanium dioxide particles treated with stearic acid). Therein, an anionic surfactant (e.g. sodium lauryl sulfate, sodium polyoxyethyleneoleylether phosphate) is added to the W/O emulsion preparation in an amount of 0.1-5wt.%, preferably 0.1-2wt.%. Furthered, an oiling agent, a humectant, a surfactant, a metal-blocking agent, a UV light absorbent, a medicine, a coloring agent, a powdery material, a perfume, etc., are suitably compounded to prepare the preparation for the external uses for the skins. The surfactant further includes di-2-ethylhexylsulfosuccinic acid sodium salt, linear dodecylbenzene sulfonic acid sodium salt and N-lauroylglutamic acid monosodium salt.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation comprising a W / O emulsion formulation containing a hydrophobic powder and an anion activator.

[0002]

[Related Art] It is well known that W / O emulsion-type formulations have superior functions to O / W emulsion formulations in terms of water resistance and sweat resistance, and are advantageous for sun care products such as sunscreens. Is. When applying a W / O formulation to sunscreen, it is possible to improve the dispersibility by hydrophobizing titanium oxide or zinc oxide that is blended as an ultraviolet scattering agent to enhance the ultraviolet protection effect, or by using hydrophobic powder in combination. It was improving, but it was insufficient.

[0003]

An object of the present invention is to provide an external preparation for skin in which the dispersibility of a hydrophobic powder in a W / O emulsion preparation is improved.

[0004]

[Means for Solving the Problem] The present inventor, as a result of diligent studies in view of the circumstances involved, has found that W / O containing a hydrophobic powder has been blended.
It has been found that the above problems can be solved by incorporating an anion activator in an emulsified preparation, and the present invention has been completed.

That is, the present invention is characterized in that a W / O emulsion formulation containing a hydrophobic powder is an external preparation for the skin containing an anion activator.

[0006]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

Examples of the anionic surfactant used in the external preparation for skin of the present invention include a base for soap, fatty acid soap such as sodium laurate and sodium palmitate, higher alkyl sulfate ester such as sodium lauryl sulfate and K lauryl sulfate. Salts, POE lauryl sulfate triethanolamine, POE sodium lauryl sulfate and other alkyl ether sulfate salts, lauroyl sarcosine sodium and other N-acyl sarcosinic acid, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium, Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride, PO
E Sodium oleyl ether phosphate, phosphate ester salts such as POE stearyl ether phosphate, sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc. Alkylbenzene sulfonates such as salts, sodium linear dodecyl benzene sulfonate, triethanolamine linear dodecyl benzene sulfonate, and linear sodium dodecyl benzene sulfonate, monosodium N-lauroyl glutamate, N
-N-acylglutamates such as disodium stearoylglutamate and monosodium N-myristoyl-L-glutamate, higher fatty acid ester sulfate salts such as hydrogenated coconut oil fatty acid glycerin sodium sulfate, sulfated oils such as funnel oil, POE alkyl ethers Carboxylic acid, POE alkyl allyl ether carboxylate, α-
Olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate ester salt, higher fatty acid alkylolamide sulfate ester salt, lauroyl monoethanolamide sodium succinate, N-palmitoyl aspartate ditriethanolamine, sodium caseinate dodecane-1 , 2-diol sodium acetate sodium, maltitol hydroxyalkyl (C12, C1
4) Examples include ether. These can be used alone or in combination of two or more.

The blending amount is preferably 0.1% by weight to 5% by weight, more preferably 0.1% by weight to 2% by weight. When the content of the anion activator is less than 0.1% by weight, it may be difficult to completely disperse the hydrophobic powder. On the other hand, even if the amount of the anion activator added exceeds 5% by weight, the effect on the dispersibility of the hydrophobic powder does not change, but the safety to the skin may deteriorate.

Examples of the hydrophobic powder used in the present invention include polyamide resin powder (nylon powder), polyethylene powder, polymethylmethacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, and benzoguanamine resin. Examples of the powder include powder, organic powder such as polytetrafluoroethylene powder and cellulose powder, silicon powder such as trimethylsilsesquioxane powder, and various hydrophobized powders. The powder components of the hydrophobized powder include talc, carion, mica, sericite, muscovite, phlogopite,
Synthetic mica, phlogopite, biotite, lithia mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salt, magnesium, silica, zeolite , Barium sulfate, calcined calcium sulfate, (calculated gypsum), calcium phosphate, fluoroapatite, hydroxyapatite,
Ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate),
Inorganic powders such as boron nitride, inorganic white pigments such as titanium dioxide and zinc oxide, iron oxide (red iron oxide), inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, ocher Inorganic yellow pigments such as black iron oxide, carbon black, inorganic black pigments such as low-order titanium oxide, inorganic purple pigments such as mango violet and balt violet, inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate Pigments, ultramarine blue, inorganic blue pigments such as navy blue, titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scales, aluminum powder, Examples include metal powder pigments such as copper powder. These may be used alone or in combination of two or more. However, the powder may be any powder that can be applied to general cosmetics, and is not limited to the above components.

In the external preparation for skin of the present invention, an oil agent, a moisturizing agent, a surfactant, a sequestering agent, an ultraviolet absorber, a drug which are commonly used in cosmetics within the range of not impairing quality such as appearance stability and viscosity. , Colorants, powders, fragrances and the like can be added.

Examples of oil agents are avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern oil, castor oil, Flaxseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Solid fats and oils such as glycerin trioctanoate and glycerin triisopalmitate include cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, mutton fat, hardened beef tallow, palm kernel oil, pork fat, beef bone fat. , Liquid oils of animals and plants such as sorghum kernel oil, hydrogenated oil, beef tallow, owl wax, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate , Liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol It waxes such as POE hydrogenated lanolin alcohol ether, liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin,
Hydrocarbon oils such as squalene, petrolatum and microcrystalline wax, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl dimethyloctanoate. Decyl, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester,
N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, tetra-2
-Ethylhexyl acid pentane erythritol, tri-2
-Glycerin ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoate glyceride, castor oil fatty acid methyl ester, oleic acid oil, Cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2
-Octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2 sebacate
-Ethylhexyl, 2-hexyldecyl myristate,
2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-succinate
Synthetic ester oils such as ethylhexyl, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, etc., dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane decamethylpolysiloxane, dodecamethylpolysiloxane, tetramethyltetrahydrogenpolysiloxane Examples include silicone oils such as siloxane.

Examples of moisturizers include polyethylene glycol, propylene glycol, glycerin, 1,3
-Butylene glycol, xylitol, sorbitol,
Maltitol, chondroitin sulphate, hyaluronic acid, mucoitin sulphate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone carboxylic acid salt, short chain soluble collagen, diglycerin (EO) PO Examples thereof include adducts, Issai rose extract, Astragalus sinensis extract, Merrilot extract and the like.

Among the surfactants, lipophilic nonionic surfactants include, for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate. , Sorbitan trioleate, penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, and other sorbitan fatty acid esters, monocottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleate glycerin, monostearate glycerin, α, α'-glycerin pyroglutamate oleate, glycerin monostearate glycerin such as malic acid, reglycerin fatty acids, propylene glycol monostearate, etc. B propylene glycol fatty acid esters, hardened castor oil derivatives, glycerin alkyl ether and the like.

Examples of the hydrophilic nonionic surfactant include POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and other POE sorbitan fatty acid esters, POE-. Solbit Monolaurate, POE-Sorbit Monooleate, POE
-POE sorbitol fatty acid esters such as sorbit pentaoleate, POE-sorbit monostearate, POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate, POE-glycerin triisostearate; POE monooleate, POE distearate,
POE monodiolate, POE fatty acid esters such as ethylene glycol distearate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, POE alkyl ethers such as POE cholestanol ether, POE octyl POE alkyl phenyl ethers such as phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether, etc., Pluronic types such as Bourronic, POE.
POE / POP alkyl ethers such as POP cetyl ether, POE / POP 2-decyltetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE / POP glycerin ether, and tetraPOE / tetraPOP ethylenediamine such as Tetronic Condensates, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, P
OE hardened castor oil lystearate, POE hardened castor oil monopyroglutamic acid monoisostearate diester, POE hardened castor oil Maleic acid and other POE castor oil hardened castor oil derivatives, POE sorbitol beeswax and other POE beeswax lanolin derivatives, palm Alkanolamides such as oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide,
POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate,
Examples thereof include alkyl ethoxydimethylamine oxide, trioleyl phosphoric acid, and the like, as long as W / O emulsification is possible, and not limited to the above.

Examples of the metal ion sequestering agent include 1-
Hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, edetate disodium, edetate trisodium, edetate tetrasodium, sodium citrate, sodium polyphosphate, metaphosphoric acid Examples thereof include sodium, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, and edetic acid.

The UV absorber may be any one that can be used in cosmetics, such as para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester,
N, N-diethoxy PABA ethyl ester, N, N-
Dimethyl PABA ethyl ester, N, N-dimethyl P
Benzoic acid type ultraviolet absorbers such as ABA butyl ester and N, N-dimethyl PABA tyl ester, homomenthyl-
Anthranilic acid type ultraviolet absorbers such as N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p
-Salicylic acid-based UV absorbers such as isopropanol phenyl salicylate, octyl cinnamate, ethyl-4
-Isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, Isoamyl-p
-Methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β -Phenylcinmate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate and other cinnamic acid-based UV absorbers, 2,4-dihydroxybenzophenone, 2 , 2'-dihydroxy-
4-methoxybenzophenone, 2,2'-dihydroxy 4,4'-dimethoxybenzophenone, 2,2 ', 4
4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4
-Methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4 Benzophenone-based UV absorbers such as -n-octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor , Urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-
t-octylphenyl) benzotriazole, 2-
(2'-hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-
Methoxy-4′-t-butyldibenzoylmethane, 5-
Examples include (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, a silicon-modified ultraviolet absorber, and a fluorine-modified ultraviolet absorber.

The dosage form of the external preparation for skin of the present invention is an oil-water emulsion composition.

[0018]

Next, the present invention will be described in more detail by way of examples. Note that the present invention is not limited to this. The compounding amount is% by weight.

(Example 1, Comparative Example 1) Sunscreen Cream (Example 1) (Comparative Example 1) (A) Squalane 19% 20% Cetyl isooctanoate 5 5 Vaseline 2 2 Polyoxyethylene oleyl ether phosphate Sodium (Hostafat KO-280: Hoechst) 10 Octyl methoxycinnamate 7 7 2-Hydroxy 4-methoxybenzophenone 2 2 4-tert-Butyl-4′-methoxydibenzoylmethane 11 Diparamethoxycinnamate Acid monooctylglycerin 11 (B) Stearic acid-treated fine particles titanium oxide 10 10 (trade name: titanium oxide MT-100T, manufactured by Teika KK) Trimethylsilsesquioxane powder 5 5 (trade name: Tospearl 145, manufactured by Toshiba Silicone KK) ) (C) Drug Amount Amount Perfume Amount The amount organic modified clay mineral (trade name: Bentone 38) 1.0 1.0 (D) POE glycerol triisostearate ester 1.5 1.5 glycerin 5 5 di Propylene glycol 3 3 PEG6000 1 1 EDTA. 3Na. 2H ₂ O 0.1 0.1 Preservative Suitable amount Suitable amount Ion-exchanged water Residual residue

[Production Method] (A) is uniformly dissolved at 60 ° C., (B) is added and the powder is dispersed by an emulsifying machine, (C) is added thereto, and the mixture is stirred uniformly and then uniformly heated to 60 ° C. The dissolved (D) is added and emulsified with an emulsifying machine. The emulsion was cooled using a heat exchanger to obtain a sunscreen cream.

[Evaluation Method] The above sample was thinly coated on a blackboard, and the dispersibility of titanium oxide was evaluated organoleptically by the whiteness of the coating color.

[Results] Example 1 ○ (Good dispersibility and transparency) Comparative Example 1 × (white coating color) From the above results, in the dispersibility of the hydrophobic powder, the anionic activator (HOFTAFAT KO-280) was used. It was confirmed that the addition contributed.

Example 2 Sunscreen Emulsion (A) Decamethylpentacyclosiloxane 25% Dimethylpolysiloxane (6CS) 10 Sodium lauryl sulfate 0.5 Isopropyl paramethoxycinnamate 5 Octylmethoxycinnamate 5 Silicone resin 3 Poly Oxyethylene / methyl polysiloxane copolymer 3 Perfume proper amount (B) Nylon powder (Brand name: Nylon SP-500, manufactured by Toray KK) 5 Methyl hydrogen polysiloxane treated fine particle titanium oxide 7 (50 nm) (C) 1.3 ． Butylene glycol 5 Preservative A suitable amount Ion exchange water Residual

(Example 3) Summer foundation Solid paraffin 2% Microcrystalline wax 6 Liquid paraffin 20 Isopropyl palmitate 6 Hostafat KO-280 (manufactured by Hoechst) 5 POE (10) Glyceryl triisostearate 2.5 POE ( 5) Hardened castor oil 2.2 Diglycerin trioleate 1.2 Preservative proper amount Antioxidant proper amount Glycerin 8 Solbit solution (70%) 5 PEG6000 2.5 Purified water Residual dextrin palmitate fine particle zinc oxide (50 nm) 1 Stearic acid Treated fine particles Titanium oxide (20 nm) 8 Silicone treated iron oxide (red, yellow, black) Appropriate amount Silicone treated titanium oxide 10

(Example 4) Glyceryl monooleate 1.5 Diglyceryl diisostearate 2.1 Triethanolamine stearate 1 Organically modified clay mineral (Benton 38) 2.2 Solid paraffin 3 Vaseline 5 Isopropyl myristate 2 Liquid paraffin 15 Polydimethylpolysiloxane (20CS) 5 Dextrin palmitate ester treated fine particles Titanium oxide 8 Polyethylene powder 5 Drug amount Amount butylparaben Amount amount Amount of antioxidant Amount amount Glycerin 6 Propylene glycol 4 Purified water Residue

Example 5 High SPF, Sunscreen Emulsion Decamethylpentacyclosiloxane 25% Dimethylpolysiloxane (6CS) 5 Isopropyl paramethoxycinnamate 5 Octylmethoxycinnamate 12 Silicone resin 5 Polyoxyethylene methylpolysiloxane Copolymer 4 Drug Appropriate amount Perfume Appropriate amount Trimethylsilsesquioxane powder (trade name: Tospearl 145, manufactured by Toshiba Silicone KK) 5 Hydrophobized titanium oxide (stearic acid treatment) 5 1.3. Butylene glycol 5 Ethanol 3 Isostearic acid potassium salt 0.5 Di-2-ethylhexyl sodium sulfosuccinate 0.2 Preservative proper amount Ion-exchanged water Residual

It was also found that in Examples 2 to 5 as well, the dispersibility of the powder was improved, so that the transparency was improved and the ultraviolet ray protection effect was also provided.

[0028]

According to the present invention, W containing a hydrophobic powder is blended.
It is possible to improve the dispersibility of the / O emulsion preparation.

Claims (2)

[Claims] 1. An external preparation for skin, which comprises one or more anionic active agents in a W / O emulsion formulation containing a hydrophobic powder. 2. The external preparation for skin according to claim 1, wherein the compounding amount of the anion activator is 0.1% by weight to 5% by weight.