JPH03167113A - Hair regenerating agent - Google Patents

Abstract

PURPOSE:To obtain a hair regenerating agent containing adenosine-3', 5'-cyclic monophosphate, pyruvic acid, fermentation metabolite, cepharandine, royal jelly, herb extract and capable of promoting hair growth and rearing of hair and preventing alopecia. CONSTITUTION:0.001-5wt.% adenosine-3', 5'-cyclic monophosphate, 0.01-5wt.% pyruvic acid and 0.1-10wt.% fermentation metabolite (e.g. yeast extract), 0.001-0.01wt.% cepharanthine, 0.1-10wt.% royal jelly and 0.06-6wt.% herb extract are dissolved in water or lower alcohols such as ethanol. In this time, conventional additive and medicine are properly blended with the above-mentioned ingredients and the blend is prepared to provide the aimed product. The hair regenerating agent is free from cumulative irritation and has excellent hair regenerating effect.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a novel hair nourishing agent. More specifically, the present invention relates to a hair nourishing agent with excellent hair nourishing effects that can promote hair growth and growth and prevent hair loss.

[Conventional technology]

Various proposals have been made regarding the mechanisms of hair loss and hair growth, but no established theory has been established.The majority of these theories promote blood circulation in the scalp and stimulate the growth of hair follicles. It seems that activating cell function is a factor that promotes hair growth and hair growth.

There is also a theory that providing energy to the dermal papilla promotes hair growth.

According to each of these theories, hair tonics containing substances that promote blood circulation as active ingredients (for example, JP-A-62-145007, JP-A-59-13744)
Publication No. 8, JP-A-60-16925, JP-A-62
-4215 Publication, Japanese Patent Application Laid-Open No. 60-136589)
Hair tonics containing substances that impart energy to hair and dermal papilla as an active ingredient (for example, JP-A-60-116620, JP-A-58-85808, JP-A-60-1)
16616, JP-A-61-152613)
is proposed.

[Problem to be solved by the invention]

However, the mechanisms of hair loss and hair growth are extremely complex, and simply promoting blood circulation in the scalp or providing energy to the dermal papilla cannot sufficiently prevent hair loss, promote hair growth,
Hair growth cannot be sufficiently promoted.

Therefore, a hair nourishing agent with better hair nourishing effect, namely,
The emergence of a hair tonic that can further promote hair growth and hair growth and effectively prevent hair loss is desired.

[Means to solve the problem]

In view of the above circumstances, the present inventor has conducted various researches in order to develop a hair nourishing agent with excellent hair nourishing effects, and has found that adenosine
3',5'-cyclic monophosphate promotes hair growth and hair growth and effectively prevents hair loss, and pyruvate and fermentation metabolites promote the production of adenosine-3',5'-cyclic monophosphate. Adenosine-3',5'-cyclic monophosphate's hair-nourishing effect promotes hair-nourishing effects such as hair growth and hair loss prevention effects, and when cephalanthine, royal jelly, and medicinal herb extracts are added to these. The effect is further improved,
It was discovered that a hair nourishing agent with excellent hair nourishing effects can be obtained, and the present invention was completed.

That is, the present invention provides a hair growth agent containing adenosine-3',5' cyclic monophosphate, pyruvic acid, fermented metabolites, cephalanthine, royal jelly, and medicinal herbal extract as active ingredients. Regarding.

Adenosine-3' used as an active ingredient in the present invention
, 5'-cyclic monophosphate is expressed in English as Adenosine-3'+5' cycl
ic■onophosphate, and its chemical structural formula is as follows.

H Pyruvic acid is represented by the chemical structural formula CH, C0C00H, and is a substance known as an important intermediate in the metabolic pathway of substances in living organisms.

The fermented metabolites used in the present invention include yeast extract, bifidus extract, etc. Yeast extract is an extract obtained by autolyzing and concentrating baker's yeast without destroying vitamins and nucleotides (substances inherent in yeast). It contains a wide variety of vitamin B, and as described below, this vitamin B is considered to be a factor that promotes the hair-nourishing effect of adenosine-3',5'-cyclic monophosphate.

In addition, bifidus extract is an extract obtained by culturing bifidobacteria, and it contains substances (enzymes) derived from the bifidism pathway, and produces adenosine triphosphate, which is an energy substance for hairy skin. ',5'
- It is thought that this is a factor that promotes the hair-nourishing effect of cyclic monophosphate.

These yeast extracts and bifidus extracts may be used alone or in combination.

Cephalanthine, royal jelly, medicinal herb extracts,
Substances have been used for this type of application in the past, but in the present invention, as medicinal herbal extracts, carrot extract, Japanese japonica extract, japonica extract, japonica extract, japonica extract, orientalis extract, etc. are used singly or in combination. It is used by mixing more than one species.

The above-mentioned adenosine-3',5'-cyclic monophosphate exhibits an excellent hair-nourishing effect, and pyruvate and fermentation metabolites of adenosine-3',5'-cyclic monophosphate have an excellent hair-nourishing effect. The reason why the addition of cephalanthine, royal jelly, and medicinal herb extract further improves the hair-nourishing effect is not entirely clear at present, but it is thought to be as follows.

First, considering adenosine-3',5'-cyclic monophosphate, pyruvate, and fermentation metabolites, glycogen exists in hair R111m, and the metabolism of this glycogen (that is, glycogen glycolysis, pentose cycle and TCA cycle) provide the energy that causes cell division and keratinization in the bulb, and this cell division and keratinization in the bulb promotes hair growth and hair growth and prevents hair loss, but the adenosine-3 mentioned above ',5
'-Cyclic monophosphate participates in glycogen glycolysis, promotes glycogen metabolism, causes bulb cell division and keratinization, promotes hair growth, and prevents hair loss.

Adenosine-3',5'-cyclic monophosphate also regenerates skin tissue, increases the blood vessel network, and increases blood flow to the scalp, resulting in an increase in the amount of glycogen supplied from the blood. It increases in size and is converted into energy substances through the glycolytic system, activating hair matrix cells, promoting hair growth and hair growth, and preventing hair loss.

Pyruvate is a TCA in the glycogen metabolic pathway.
It promotes the hair growth, hair growth and hair loss prevention effects of adenosine-3',5'-cyclic monophosphate.

In addition, as mentioned above, yeast extract as a fermentation metabolite contains a large amount of vitamin B, which promotes glycogen metabolism and adenosine-3',5'
- Promote the hair-nourishing effect of cyclic monophosphate.

Bifidus extract contains an enzyme derived from the Bifism pathway, and this enzyme produces adenosine triphosphate, which promotes glycogen metabolism and adenosine-3', 5'- Promotes the hair growth effect of cyclic monophosphate.

In the present invention, in addition to these adenosine-3',5' cyclic monophosphate, pyruvate, and fermented metabolites, cephalanthine, royal jelly, and medicinal herb extracts are added. In this way, adenosine-
It is currently unclear whether 3',5'-cyclic monophosphate improves the hair-nourishing effect, but these cephalanthine, royal jelly, and medicinal herb extracts have the following properties, which are adenosine-
It is thought that this improves the hair-nourishing effect of 3',5'-cyclic monophosphate.

Cephalanthine is an alkaloid extracted from a plant belonging to the family Cephalanthiaceae, and has the following effects.

■ Acts on the cell plasma of nerves, muscles, and other tissues, increasing their function.

■ Immune production effect ■ Effect on the reticuloendothelial system ■ Anti-allergic effect ■ Toxin neutralization effect ■ Parasympathetic tone-relaxing effect Royal jelly also normalizes excessive sebum secretion, which is thought to be one of the causes of hair loss. It has an effect.

Medicinal herb extracts have long been known as herbal medicines and contain various vitamins, which have a positive effect on the hair-nourishing effect of adenosine-3',5'-cyclic monophosphate. considered to be a thing.

In contrast to such a hair tonic of the present invention, even conventional hair tonics,
The method of promoting or increasing blood circulation is to dilate blood vessels or apply stimulation (heating, cooling) to the scalp, and the reaction to that stimulation increases blood flow. Since it does not produce hair growth, hair growth or hair loss prevention effects by continuously promoting glycogen metabolism and causing bulb cell division and keratinization as in the present invention, it does not produce hair growth, hair growth or hair loss prevention effects. The probability is less than in the case of the present invention.

In preparing the hair tonic of the present invention, the active ingredients adenosine-3',5'-cyclic monophosphate, pyruvic acid, fermented metabolites, cephalanthine, royal jelly, and medicinal herbal extracts are mixed in water, ethanol, etc. It can be dissolved in lower alcohols, etc.
At that time, it may be prepared with additives and drugs acceptable for this type of use, or it may be prepared in other dosage forms.

The above additives and drugs include blood circulation promoters, metabolism promoters, anti-androgen agents, anti-inflammatory agents, anti-allergy agents,
Moisturizer, nourishing agent for the scalp, antibacterial agent, cooling agent, oil, surfactant, fragrance, antioxidant, ultraviolet absorber, pigment, thickener, pH! Examples include II conditioning agents, chelating agents, etc.
Specific examples of these additives and drugs include tocophenol acetate, carpronium chloride, minoxidil, carbon dioxide, hinokitiol, pantonyl ethyl benzoate, glyceride pentadecanoate, vitamin 1, and ethinyl. Estradiol, glycyrrhizic acid, diphenylhydramine hydrochloride, hyaluronic acid, Minisasanishiki extract, mononitroguaiacol, capsicum tincture, Shokimachitsu tincture, fibroblast activated prisoner extract, hydrocortiscin, diphenhydramine hydrochloride, soluble cystine, D- pantothenyl alcohol,
These include salicylic acid, lactic acid, sodium lactate, placenta extract, and menthol.

In the above hair tonic, the active ingredient adenosine-3
',5'-cyclic monophosphate is 0.01~
It is suitable to contain 5% by weight, preferably 0.01 to 0.1% by weight. In other words, adenosine-3',5'
- If the content of cyclic monophosphate in the hair growth agent is less than 0.01% by weight, the effect of promoting glycogen metabolism, promoting hair growth, and preventing hair loss will not be sufficiently exhibited; Also, adenosine-3',5'-
Even if the content of cyclic monophosphate in a hair growth agent was increased to more than 5% by weight, no increase in the effect of promoting hair growth and hair growth was observed, and adenosine-3',5'-cyclic monophosphate This is because there is a risk of side effects on the circulatory system, respiratory system, digestive system, etc.

Further, it is appropriate that pyruvic acid be contained in the hair nourishing agent in an amount of 0.01 to 5% by weight, preferably 0.10 to 1.0% by weight. In other words, if the content of pyruvate is less than 0.01% by weight, TC in the glycogen metabolic pathway
The effect of promoting A is not sufficiently exerted, and therefore the effect of promoting the hair-nourishing effect of adenosine-3',5'-cyclic monophosphate is reduced. However, adenosine-3
This is because the effect of promoting hair growth and hair growth of ',5'-cyclic monophosphate is not increased, and the increase in pyruvic acid may make the acidity too strong and cause skin irritation.

The fermented metabolites are 0.1 to 10% by weight in the hair nourishing agent.
Preferably, it has a weight of 0.5 to 5. In other words, when the content of fermentation metabolites is less than 0.1% by weight, glycogen metabolism is promoted and adenosine
The effect of 3',5'-cyclic monophosphate in promoting hair growth was not sufficiently demonstrated, and even if the content of fermentation metabolites was increased beyond 10% by weight, adenosine-3
This is because the effect of promoting the hair-nourishing action of the ',5'-cyclic monophosphate does not increase.

In addition, cephalanthine is present in hair growth products in amounts of 0.001 to 0°0.
It is suitable to contain 1% by weight, preferably 0.002 to 0.00% by weight. In other words, when the content of cephalanthine is less than 0.001, the effect of adenosine-3',5'-cyclic monophosphate on improving the hair growth effect is small; .01% by weight may cause side effects such as skin irritation.

It is appropriate that royal jelly is contained in the hair nourishing agent in an amount of 0.1 to 10% by weight, preferably 0.2 to 2.0% by weight. In other words, if the royal jelly content is less than 0.1% by weight, the effect of improving the hair-nourishing effect of adenosine 3',5'-cyclic monophosphate will be reduced; This is because even if the amount is increased, no improvement in the function of normalizing sebum secretion will be observed.

Further, it is appropriate that the medicinal herb extract be contained in the hair nourishing agent in an amount of 0.06 to 6.0% by weight, preferably 0.3 to 1.0% by weight. In other words, the content of medicinal herb extract is 0.0
If it is less than 6% by weight, the effect of promoting glycogen metabolism and improving the hair-nourishing effect of adenosine-3',5'-cyclic monophosphate will not be fully exhibited, and the medicinal herbal extract will not be effective. This is because even if the content is more than 6.0% by weight, the effect of improving the hair growth effect will not increase and stickiness will occur.

〔Example〕

Next, the hair growth effect of the hair growth agent of the present invention will be specifically explained with reference to Examples, but the present invention is not limited to the Examples.

Examples 1 to 3 and Comparative Example 1 Hair nourishing agents were prepared according to the formulations shown in Table 1. In addition, the first
The amount of each component in the table is shown in weight%.

The hair growth agents of Examples 1 to 3 and Comparative Example 1 were examined for their hair growth effects on white mice and on human hair.

(1) After cutting the hair on the shoulder blades of a white mouse (male, 6 weeks old) with electric clippers, the hair was completely removed with hair removal cream, and from the next day, the hair growth agents of Examples 1 to 3 and the comparison were used. Apply the hair restorer of Example 1 to the skin of the test area twice daily in the morning and evening - 0.1 mj per animal!
(However, the area of the test area was 2 cm x 3 cm). One group of mice was used for each hair growth agent.
0 mice were used, and the hair growth effect was determined by observing whether or not there was hair growth every 3 days, and similarly measuring the length of the hair every 3 days. The results are shown in Tables 2 and 3, respectively, with the exception that hair lengths are shown after 6 days.

Regarding the hair growth rate, as shown in Table 2, Examples 1 to 3
The hair growth agent of Comparative Example 1 had a hair growth rate of 20% on the 3rd day after application, but the hair growth rate of Comparative Example 1 did not show until 122 days after application.
3',5'-cyclic monophosphate, pyruvate, fermentation metabolites, cephalanthine, royal jelly,
The hair growth effect of medicinal herbal extracts was clear.

Regarding the length of mouse hair, as shown in Table 3, the hair growth promoting effects of the hair growth agents of Examples 1 to 3 were found to be more pronounced than that of the hair growth agent of Comparative Example 1.

In addition, from the observation results for 30 days, no abnormal behavior was observed in mice due to the application of the hair restorers of Examples 1 to 3 and the hair restorer of Comparative Example 1, and no redness, edema, or skin formation of the skin was observed at the application site. was not observed, and it is considered that there is no cumulative irritation to the skin.

(2) The following tests were conducted for each of the Examples listed in Section 1, while comparing them with Comparative Example 1.

Both the left and right bottles (sample) of 10 adult males were shaved, and a 1c11 square part of each was used as the test area, and the hair tonic of each example was placed in the bottle on the right, and the hair tonic of Comparative Example 1 was placed in the bottle on the left. 1 ml of the solution was applied to each test area twice a day, morning and evening. The effectiveness was determined at lO0 after the start of the test.
On day 1, shave 20 hairs from the roots of the tested parts of the left and right bottles, and change the average length of the 5120 hairs on the right (Y) to the average length of the 20 hairs on the left (Y). The bond was divided by X) and evaluated. The results are shown in Table 4.

Table 4 As shown in Table 4, in Examples 1 to 3, the XZY value was 1.
It was revealed that the hair growth agents of Examples 1 to 3 had a greater effect on promoting hair growth, that is, a hair growth effect.

(Effects of the Invention) As explained above, the hair nourishing agent of the present invention exhibited excellent hair nourishing effects, and no irritant irritation was observed upon application, making it extremely valuable as a hair nourishing agent.

Claims (1)

[Claims] (1) A hair tonic containing adenosine-3',5'-cyclic monophosphate, pyruvic acid, fermented metabolites, cephalanthine, royal jelly, and medicinal herbal extract as active ingredients.