JPH0338515A - Tooth paste for inhibiting bacterial plaque on teeth - Google Patents

Abstract

PURPOSE:To obtain a tooth paste for inhibiting bacterial plaque on teeth which has action to prohibit effectively dental cavity microorganisms from taking roots and prevent and treat tooth decay and periodontoses by using a specific acrylic copolymer, a specific nonionic surface active agent and water. CONSTITUTION:The subject mouth-washing agent contains, as essential components, 0.001 to 10wt.% of a copolymer from monomers of formula I, formula II and formula III (R1 to R3 are H, methyl; R4 and R5 are 1 to 18C alkyl wherein R2 and R3, R4 and R5 are not same simultaneously) and 0.05 to 15wt.% of a nonionic surfactant selected from the group consisting of polyoxyethyleneoxyfatty acid triglyceride derivatives, polyoxyethylene sorbitan fatty acid esters and block polymer type surfactants. Additionally, the agent is combined with other usually used components appropriately and the total mixture is compounded in a usual manner to give tooth paste, tooth powder and other denitrifies. The average molecular weight of the copolymer is 10,000 to 200,000.

Description

[Detailed description of the invention] The present invention has the effect of suppressing oral bacteria, that is, the adhesion of dental plaque to the teeth, and has the effect of preventing caries and preventing periodontal disease. - Concerning toothpaste that inhibits plaque adhesion and has a therapeutic effect.

Conventional techniques and issues It has been clarified that dental caries and periodontal disease are caused by dental plaque. It is caused by the acid produced by metabolizing tooth enamel, which demineralizes tooth enamel. Also, certain bacteria in plaque secrete enzymes and endotoxins that irritate the gums, causing inflammation in the gums. The gums then bleed, lose their elasticity, and eventually sag away from the teeth, creating periodontal pockets. This periodontal pocket becomes a home for anaerobic bacteria, and the enzymes and endotoxins produced by these bacteria destroy the periodontal tissue, causing periodontal disease.

Therefore, in order to prevent such onset, many methods have been proposed to suppress the adhesion of dental plaque to teeth (Japanese Patent Laid-Open No. 60-16
No. 9423, Japanese Unexamined Patent Publication No. 63-8325, etc.), but none of them are completely satisfactory.

An object of the present invention is to provide a novel toothpaste that is excellent in suppressing the adhesion of dental plaque (oral bacteria) to teeth.

Means for Solving the Problems The present inventors have discovered that the adhesion of Streptococcus mutans to hydroxyapatite beads covered with saliva, which is a model system for the adhesion of dental plaque to teeth, is caused by the adhesion of Streptococcus mutans to a specific acrylic compound. The present inventors have discovered that a dentifrice containing a polymer and a specific nonionic surfactant effectively inhibits plaque adhesion and is useful as a dentifrice for suppressing plaque adhesion, and has completed the present invention.

That is, the present invention has, as an essential component, the formula (a); [wherein R1, R2, and R3 are hydrogen or methyl groups, and R4 and R6 are alkyl groups having 1 to 18 carbon atoms. However, R8 and R5 and R4 and R6 cannot be the same group at the same time. ] A copolymer obtained by copolymerizing the monomers shown below.

(b) 1 selected from the group consisting of polyoxyethylene oxyfatty acid triglyceride derivatives, polyoxyethylene sorbitan fatty acid esters, and block polymer types;
The present invention provides a toothpaste that suppresses plaque adhesion and is characterized by containing one or more nonionic surfactants.

Note that oral compositions are known that suppress tartar formation by blending a copolymer of polyacrylic acid and 3-hydroxypropyl methacrylate to chelate calcium ions that form tartar. (Unexamined Japanese Patent Publication No. 1986-
No. 165317) is completely different from the present invention in the type of copolymer used and the purpose of application.

The copolymer used in the present invention is obtained by copolymerizing the monomer of formula [1], the monomer of formula [1], and the monomer of formula [■], and preferably has a weight average molecular weight of from about 10,000 to about 200,000, more preferably from about 50,000 to I 00,000. These are product names Plus Size L-53D and Plus Size L-5.
It is available as 3P (manufactured by Gooh Kagaku Co., Ltd.).

The amount of the copolymer used in the toothpaste of the present invention is generally about 0001% by weight to about 1010% by weight, preferably about 0.01% by weight.
05% to about 8.0% by weight, more preferably about 0.01% by weight
% to about 5.0% by weight. If the blending amount is less than 0.001% by weight, the effect of inhibiting plaque adhesion will not be sufficient,
On the other hand, if the amount exceeds 10.0% by weight, the viscosity becomes too high to be used.

In addition, the nonionic surfactants used in the present invention include (1) polyoxyethylene oxyfatty acid triglyceride derivatives, such as polyoxyethylene hydrogenated castor oil derivatives, polyoxyethylene castor oil derivatives, etc. (2) polyoxyethylene sorbitan fatty acid ester,
For example, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate,
(3) Block polymer types such as polyquine ethylene sorbitan monopalmitate, such as Pluronic and Tetronic.

Such nonionic surfactants may be used alone or in combination of two or more.

The amount of nonionic surfactant used in the mouthwash of the present invention is generally about 0.05% by weight to about 15.0% by weight, preferably about 0.1% by weight to about 5.0% by weight. , more preferably about 0.5% to about 1.5% by weight. Blend amount is 0
．． If it is less than 0.05% by weight, the effect of suppressing plaque adhesion will not be sufficient, while if it is more than 15.0% by weight, the viscosity will become too high and it will not be suitable for use.

The toothpaste of the present invention can be made into the form of a toothpaste, powdered toothpaste, moisturized toothpaste, etc. (excluding mouthwash) by a conventional method, and other ingredients are not particularly limited. Any of the commonly used ingredients can be included. For example, dibasic calcium phosphate, calcium carbonate, calcium birophosphate, insoluble sodium metaphosphate, amorphous silica,
Crystalline glue, abrasives such as alumina silicate, aluminum oxide, aluminum hydroxide, binders such as carboxymethylcellulose, hydroxyethylcellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, sorbitol, glycerin , thickening agents such as propylene glycol, foaming agents such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monoglyceride sulfate, sodium lauryl sulfoacetate, and N-acylglutamate, flavorings, sweeteners, and preservatives. Agents and the like can be added as appropriate.

Next, the present invention will be explained in more detail with reference to Examples and Comparative Examples.

Example 1~! 6 and Comparative Examples 1 to 9 Toothpastes were manufactured by a conventional method according to the formulations shown in Table 1. Using the obtained toothpaste, the effect on adsorption of Streptococcus mutans 6715 onto saliva-coated hydroxyapatite (HAP) beads was investigated in the following manner.

(1) 20H HAP beads were incubated with 0.5 iQ of human saliva (blood type 0) for 1 hour at room temperature. The beads were mixed with 0.05M KCQ, 1mM KH,
P O,, 1mM CaC12t and liM MgC
Washed twice with buffer Lx (l) of Ct pi (6,0).

(This buffer mimics the inorganic components of saliva).

Then, at room temperature, the beads were ink spaded with 0.5i12 of a pH 7.0 polymer solution (sample solution) for 1 hour, and washed twice with the above-mentioned mild #dlj.

Next, a suspension containing 5.0 x 10' [3H]thymidine-labeled bacteria (Streptococcus mutans) in 0.5 ml of the buffer was added to the beads,
Incubated for 1 hour at room temperature. Said buffer 1x (
After washing three times with l, the beads were transferred to a vial and radioactivity was counted using a liquid scintillation counter. On the other hand, the percentage of known ['H]-labeled cells was counted using the same method,
A calibration curve for the number of bacteria was created.

The sample solution used in the experiment was prepared by weighing out 1 g of toothpaste and
Ox (add 1 of distilled water, stir, suspend, 15.00O
After centrifugation at rpm for 15 minutes, the supernatant was collected and used as a sample solution. The results are shown in Table 1.

In Table 1, the viscosity and overall evaluation were determined based on the following criteria.

Viscosity (according to organoleptic) O: Good ×; Too expensive to be used.

Overall evaluation ○: The relative ratio of the effect on adsorption is 50% or less and the viscosity is ○.

×: The relative ratio of the effect is greater than 50% without adsorption, or the viscosity is X.

Example 17 According to the following prescription, Manufacture toothpaste using conventional methods Ta.

component glycerin polyoxyethylene hardening Castor oil (60E, O,) ethanol Sodium hydroxide saccharin sodium Plus size L-53D Methyl roseoxybenzoate fragrance purified water Example 18 According to the following prescription, Ta.

Toothpaste was manufactured using a conventional method, and the ingredient sorbitol blended amount (%) 0 1.5 0 0.4 0.2 2.0 0.1 3 Remaining blended amount (%) Glycerin polyoxyethylene polyquinopropylene glycol ethanol 15 Water Sodium oxide 0.0 1 Saccharin sodium o2 Brassize L-53
P 0.1 methyl oxybenzoate
o. l fragrance
o3 Purified water Remainder Example 19 A toothpaste was manufactured by a conventional method according to the following recipe.

Ingredients Amount (%) Glycerin
10 polysorbate 80
1 ethanol
10 Sodium hydroxide O
05 Sanocalin sodium 0.2
Plus size L-53D 0 5 Sodium benzoate 0.1 Fragrance
03 Kiyoshi Ice
Remaining Effects of the Invention According to the present invention, a toothpaste that effectively suppresses the adhesion of dental plaque to teeth can be obtained.

Claims (3)

[Claims] (1) As essential components, (a) Formulas: ▲There are mathematical formulas, chemical formulas, tables, etc.▼［I］▲There are mathematical formulas, chemical formulas, tables, etc.▼［II］▲There are mathematical formulas, chemical formulas, tables, etc.▼［III [In the formula, R_1, R_2, and R_3 represent hydrogen or a methyl group, and R_4 and R_5 represent an alkyl group having 1 to 18 carbon atoms. However, R_2 and R_3, R_4 and R_5
and cannot be based on the same base at the same time. ] A copolymer obtained by copolymerizing the monomers shown below. (b) 1 selected from the group consisting of polyoxyethylene oxyfatty acid triglyceride derivatives, polyoxyethylene sorbitan fatty acid esters, and block polymer types;
A toothpaste that suppresses plaque adhesion, characterized in that it contains one or more nonionic surfactants. (2) The average molecular weight of the copolymer is 10,000 to 200
,000. The toothpaste according to claim (1). (3) The toothpaste according to claim (1) or claim (2), which contains 0.001 to 10% by weight of the copolymer.