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JPS54138126A - Remedy for diabetes - Google Patents

Remedy for diabetes

Info

Publication number
JPS54138126A
JPS54138126A JP4501478A JP4501478A JPS54138126A JP S54138126 A JPS54138126 A JP S54138126A JP 4501478 A JP4501478 A JP 4501478A JP 4501478 A JP4501478 A JP 4501478A JP S54138126 A JPS54138126 A JP S54138126A
Authority
JP
Japan
Prior art keywords
diabetes
remedy
butanediol
remarkably effective
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4501478A
Other languages
Japanese (ja)
Inventor
Hachiro Nakagawa
Akira Tai
Miharu Izumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP4501478A priority Critical patent/JPS54138126A/en
Publication of JPS54138126A publication Critical patent/JPS54138126A/en
Pending legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: To provide a remedy for diabetes having low side effects and remarkably effective even by oral administration, containing L-1,3-butanediol.
CONSTITUTION: A remedy for diabetes containing L-1,3-butanediol (L-BD) as an active component. The L-BD has far better blood sugar leveldepressing activity than the D-BD and DL-BD, has even sugar production lowering activity, and is remarkably effective to the initial or terminal diabetes. The L-BD can be prepared by the LiH-reduction of L-3-hydroxubutyric acid which is obtained by the asymmetric reduction of methyl acetoacetate with a tartaric acid-modified Ni-catalyst.
COPYRIGHT: (C)1979,JPO&Japio
JP4501478A 1978-04-17 1978-04-17 Remedy for diabetes Pending JPS54138126A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4501478A JPS54138126A (en) 1978-04-17 1978-04-17 Remedy for diabetes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4501478A JPS54138126A (en) 1978-04-17 1978-04-17 Remedy for diabetes

Publications (1)

Publication Number Publication Date
JPS54138126A true JPS54138126A (en) 1979-10-26

Family

ID=12707494

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4501478A Pending JPS54138126A (en) 1978-04-17 1978-04-17 Remedy for diabetes

Country Status (1)

Country Link
JP (1) JPS54138126A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428066A (en) * 1989-03-08 1995-06-27 Larner; Joseph Method of reducing elevated blood sugar in humans
JP2001515510A (en) * 1997-03-17 2001-09-18 ビーティージー・インターナショナル・リミテッド Therapeutic composition
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
US9211275B2 (en) 2008-01-04 2015-12-15 Isis Innovation Ltd. Ketone bodies and ketone body esters as blood lipid lowering agents
US9579302B2 (en) 2012-11-05 2017-02-28 Tdeltas Ketone bodies to protect tissues from damage by ionizing radiation
US10660958B2 (en) 2010-02-22 2020-05-26 Tdeltas Limited Nutritional composition
US10821062B2 (en) 2013-03-12 2020-11-03 Tdeltas Limited Compound for use in protecting skin
US11230722B2 (en) 2003-06-03 2022-01-25 Oxford University Innovation Limited Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives
US11566268B2 (en) 2013-03-14 2023-01-31 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Process for producing (R)-3-hydroxybutyl (R)-3-hydroxybutyrate

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428066A (en) * 1989-03-08 1995-06-27 Larner; Joseph Method of reducing elevated blood sugar in humans
JP2001515510A (en) * 1997-03-17 2001-09-18 ビーティージー・インターナショナル・リミテッド Therapeutic composition
EP1017379A4 (en) * 1997-03-17 2007-01-24 Btg Int Ltd Therapeutic compositions
JP2009173677A (en) * 1997-03-17 2009-08-06 Btg Internatl Ltd Composition for therapy
EP2283834A3 (en) * 1997-03-17 2012-02-01 BTG International Limited Therapeutic compositions comprising ketone bodies or their precursors
JP2015042644A (en) * 1997-03-17 2015-03-05 ビーティージー・インターナショナル・リミテッド Therapeutic compositions
US11230722B2 (en) 2003-06-03 2022-01-25 Oxford University Innovation Limited Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives
US9211275B2 (en) 2008-01-04 2015-12-15 Isis Innovation Ltd. Ketone bodies and ketone body esters as blood lipid lowering agents
US11311509B2 (en) 2008-01-04 2022-04-26 Oxford University Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
US10154982B2 (en) 2008-01-04 2018-12-18 Oxford University Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
US10051880B2 (en) 2008-08-21 2018-08-21 Oxford University Innovation Limited Hydroxybutyrate ester and medical use thereof
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
US10660958B2 (en) 2010-02-22 2020-05-26 Tdeltas Limited Nutritional composition
US11571479B2 (en) 2010-02-22 2023-02-07 Tdeltas Nutritional composition
US10478415B2 (en) 2012-11-05 2019-11-19 Tdeltas Limited Ketone bodies to protect tissues from damage by ionizing radiation
US11234953B2 (en) 2012-11-05 2022-02-01 Tdeltas Limited Ketone bodies to protect tissues from damage by ionizing radiation
US9579302B2 (en) 2012-11-05 2017-02-28 Tdeltas Ketone bodies to protect tissues from damage by ionizing radiation
US10821062B2 (en) 2013-03-12 2020-11-03 Tdeltas Limited Compound for use in protecting skin
US12377032B2 (en) 2013-03-12 2025-08-05 Tdeltas Limited Compound for use in protecting skin
US11566268B2 (en) 2013-03-14 2023-01-31 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Process for producing (R)-3-hydroxybutyl (R)-3-hydroxybutyrate

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