JPS5566580A - Coumarin derivative, its preparation and antiallergic agent containing the same as effective component - Google Patents
Coumarin derivative, its preparation and antiallergic agent containing the same as effective componentInfo
- Publication number
- JPS5566580A JPS5566580A JP13923178A JP13923178A JPS5566580A JP S5566580 A JPS5566580 A JP S5566580A JP 13923178 A JP13923178 A JP 13923178A JP 13923178 A JP13923178 A JP 13923178A JP S5566580 A JPS5566580 A JP S5566580A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- antiallergic agent
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Coumarin derivatives of formula I (R is H, alkyl, halogen; n is 1, 2; two Rs arbitrarily adjacent to each other may form a condensed ring along with binding carbon atoms). EXAMPLE:6-Isopropyl-3-(1H-tetrazol-5-yl)coumarin. USE:Antiallergic agent; they depress histamines from mast cells caused by immune reactions and the liberation of SRS-A and are used as remedy and preventive for allergic asthma, dermatitis, rhinitis and enterogastritis. PREPARATION:A compound of formula II is made to react with hydrogen azide or its salt to give the compound of formula I. The reaction is conducted in a solvent of benzene or so, at room temperature-130 deg.C. The compounds of formula II are partially novel and, for example, obtained by reaction of a compound of formula III with a cyanomalonic ester.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13923178A JPS5566580A (en) | 1978-11-11 | 1978-11-11 | Coumarin derivative, its preparation and antiallergic agent containing the same as effective component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13923178A JPS5566580A (en) | 1978-11-11 | 1978-11-11 | Coumarin derivative, its preparation and antiallergic agent containing the same as effective component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5566580A true JPS5566580A (en) | 1980-05-20 |
| JPS6136754B2 JPS6136754B2 (en) | 1986-08-20 |
Family
ID=15240527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13923178A Granted JPS5566580A (en) | 1978-11-11 | 1978-11-11 | Coumarin derivative, its preparation and antiallergic agent containing the same as effective component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5566580A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014152213A3 (en) * | 2013-03-15 | 2014-11-13 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders |
| WO2014152278A3 (en) * | 2013-03-15 | 2014-11-13 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating hyperproliferative diseases |
| US9221840B2 (en) | 2011-05-17 | 2015-12-29 | Discoverybiomed Inc. | Treating protein folding disorders with small molecule CFTR correctors |
| US9546176B2 (en) | 2012-11-20 | 2017-01-17 | Discoverybiomed, Inc. | Small molecule bicyclic and tricyclic CFTR correctors |
| US9676779B2 (en) | 2012-11-20 | 2017-06-13 | Discoverybiomed, Inc. | Small molecule CFTR correctors |
| CN108069929A (en) * | 2016-11-18 | 2018-05-25 | 中国科学院大连化学物理研究所 | 3- substituted cumarins analog derivative and the agonist of application and GPR35 receptors |
-
1978
- 1978-11-11 JP JP13923178A patent/JPS5566580A/en active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9221840B2 (en) | 2011-05-17 | 2015-12-29 | Discoverybiomed Inc. | Treating protein folding disorders with small molecule CFTR correctors |
| US9546176B2 (en) | 2012-11-20 | 2017-01-17 | Discoverybiomed, Inc. | Small molecule bicyclic and tricyclic CFTR correctors |
| US9676779B2 (en) | 2012-11-20 | 2017-06-13 | Discoverybiomed, Inc. | Small molecule CFTR correctors |
| WO2014152213A3 (en) * | 2013-03-15 | 2014-11-13 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders |
| WO2014152278A3 (en) * | 2013-03-15 | 2014-11-13 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating hyperproliferative diseases |
| US9815825B2 (en) | 2013-03-15 | 2017-11-14 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders |
| US10369145B2 (en) | 2013-03-15 | 2019-08-06 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating hyperproliferative diseases |
| CN108069929A (en) * | 2016-11-18 | 2018-05-25 | 中国科学院大连化学物理研究所 | 3- substituted cumarins analog derivative and the agonist of application and GPR35 receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6136754B2 (en) | 1986-08-20 |
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