JPS56122368A - Guanidinothiazole compound and its preparation - Google Patents
Guanidinothiazole compound and its preparationInfo
- Publication number
- JPS56122368A JPS56122368A JP2493880A JP2493880A JPS56122368A JP S56122368 A JPS56122368 A JP S56122368A JP 2493880 A JP2493880 A JP 2493880A JP 2493880 A JP2493880 A JP 2493880A JP S56122368 A JPS56122368 A JP S56122368A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- lower alkyl
- activity
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Guanidinothiazole compound Chemical class 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000004051 gastric juice Anatomy 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 229910003844 NSO2 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- OTONQHQAXUYNSI-UHFFFAOYSA-N n'-cyano-5-[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]pentanimidamide Chemical compound NC(=N)NC1=NC(CCCCC(=N)NC#N)=CS1 OTONQHQAXUYNSI-UHFFFAOYSA-N 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A guanidinothiazole compound of formula I [R is H or lower alkyl; m is 3W5; X is O, N-R1 (R1 is H, cyano, carbamoyl, hydroxyl, etc.), or NSO2R2 (R2 is lower alkyl, aryl, amino, etc.); Y is H, lower alkyl, lower alkenyl, or lower alkynyl)], and its acid addition salt.
EXAMPLE: N-cyano-5-(2-guanidinothiazol-4-yl)pentanoamidine.
USE: The compound has gastric juice secretion suppressing activity, and histamine H2 receptor antagonistic activity, and useful as a gastric juice secretion suppressing agent. It has no side effects caused by anticholine activity.
PROCESS: The compound of formula I is prepared, e.g. by reacting the compound of formula II (R' is lower alkyl) with an amine of formula H2N-Y in a solvent such as methanol, isopropanol, etc., at room temp. or under heating, pref. under neutral or basic conditions.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2493880A JPS56122368A (en) | 1980-02-29 | 1980-02-29 | Guanidinothiazole compound and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2493880A JPS56122368A (en) | 1980-02-29 | 1980-02-29 | Guanidinothiazole compound and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56122368A true JPS56122368A (en) | 1981-09-25 |
Family
ID=12151994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2493880A Pending JPS56122368A (en) | 1980-02-29 | 1980-02-29 | Guanidinothiazole compound and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56122368A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496564A (en) * | 1981-03-09 | 1985-01-29 | Ici Americas Inc. | Amide derivatives |
| US4748165A (en) * | 1981-05-18 | 1988-05-31 | Imperial Chemical Industries Plc | Amidine derivatives |
| JPWO2015002150A1 (en) * | 2013-07-03 | 2017-02-23 | 株式会社新日本科学 | Novel compound, detection agent and activity inhibitor of organic cation transporter 3 |
-
1980
- 1980-02-29 JP JP2493880A patent/JPS56122368A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496564A (en) * | 1981-03-09 | 1985-01-29 | Ici Americas Inc. | Amide derivatives |
| US4748165A (en) * | 1981-05-18 | 1988-05-31 | Imperial Chemical Industries Plc | Amidine derivatives |
| JPWO2015002150A1 (en) * | 2013-07-03 | 2017-02-23 | 株式会社新日本科学 | Novel compound, detection agent and activity inhibitor of organic cation transporter 3 |
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