JPS5711986A - Okadaic acid, its salt, and its ester - Google Patents
Okadaic acid, its salt, and its esterInfo
- Publication number
- JPS5711986A JPS5711986A JP8680080A JP8680080A JPS5711986A JP S5711986 A JPS5711986 A JP S5711986A JP 8680080 A JP8680080 A JP 8680080A JP 8680080 A JP8680080 A JP 8680080A JP S5711986 A JPS5711986 A JP S5711986A
- Authority
- JP
- Japan
- Prior art keywords
- ester
- salt
- okadaic acid
- carboxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002148 esters Chemical class 0.000 title abstract 3
- QNDVLZJODHBUFM-WFXQOWMNSA-N okadaic acid Chemical compound C([C@H](O1)[C@H](C)/C=C/[C@H]2CC[C@@]3(CC[C@H]4O[C@@H](C([C@@H](O)[C@@H]4O3)=C)[C@@H](O)C[C@H](C)[C@@H]3[C@@H](CC[C@@]4(OCCCC4)O3)C)O2)C(C)=C[C@]21O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O QNDVLZJODHBUFM-WFXQOWMNSA-N 0.000 title abstract 3
- VEFJHAYOIAAXEU-UHFFFAOYSA-N okadaic acid Natural products CC(CC(O)C1OC2CCC3(CCC(O3)C=CC(C)C4CC(=CC5(OC(CC(C)(O)C(=O)O)CCC5O)O4)C)OC2C(O)C1C)C6OC7(CCCCO7)CCC6C VEFJHAYOIAAXEU-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 241000353756 Halichondria okadai Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An okadaic acid shown by the formula (R is carboxy or esterified carboxy), its salt, and its ester.
EXAMPLE: Okadaic acid P-bromophenacyl ester.
USE: An antitumor agent, cardiotonic, etc. Pharmaceutically manufactured into an oral agent, injection, external preparation, etc. for use. A dose as the antitumor agent for human is about 2W50γ/kg/day.
PROCESS: For example, Halichondria Okadai PORIFERA is extracted with an organic solvent (e.g., methanol, ethanol, etc.) to give an extracted solution, from which an odakaic acid shown by the formula (R is carboxy) is isolated and collected. And, if necessary, esterification or salt formation is carried out.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8680080A JPS5711986A (en) | 1980-06-25 | 1980-06-25 | Okadaic acid, its salt, and its ester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8680080A JPS5711986A (en) | 1980-06-25 | 1980-06-25 | Okadaic acid, its salt, and its ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5711986A true JPS5711986A (en) | 1982-01-21 |
Family
ID=13896864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8680080A Pending JPS5711986A (en) | 1980-06-25 | 1980-06-25 | Okadaic acid, its salt, and its ester |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5711986A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931314A (en) * | 1987-10-15 | 1990-06-05 | Nissan Chemical Industries Ltd. | Method for preventing hardened cementitious material from deteriorating |
| WO1993003365A1 (en) * | 1991-08-09 | 1993-02-18 | Iatron Laboratories, Inc. | Immunoassay, monoclonal antibody and hybridoma |
| ES2161616A1 (en) * | 1999-07-29 | 2001-12-01 | Univ Santiago Compostela | Removal of toxins from fish products by carbon dioxide consists of pressurized reaction based on supercritical carbon dioxide mixed with acetic acid |
| CN100346781C (en) * | 2005-11-16 | 2007-11-07 | 陈凤华 | Use of okadaic acid in preparation of medicine for resisting glaucoma operation scar |
| CN108949848A (en) * | 2018-08-08 | 2018-12-07 | 浙江海洋大学 | A method of it is fermented using marine bacteria and prepares sponge acid |
-
1980
- 1980-06-25 JP JP8680080A patent/JPS5711986A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931314A (en) * | 1987-10-15 | 1990-06-05 | Nissan Chemical Industries Ltd. | Method for preventing hardened cementitious material from deteriorating |
| WO1993003365A1 (en) * | 1991-08-09 | 1993-02-18 | Iatron Laboratories, Inc. | Immunoassay, monoclonal antibody and hybridoma |
| ES2161616A1 (en) * | 1999-07-29 | 2001-12-01 | Univ Santiago Compostela | Removal of toxins from fish products by carbon dioxide consists of pressurized reaction based on supercritical carbon dioxide mixed with acetic acid |
| CN100346781C (en) * | 2005-11-16 | 2007-11-07 | 陈凤华 | Use of okadaic acid in preparation of medicine for resisting glaucoma operation scar |
| CN108949848A (en) * | 2018-08-08 | 2018-12-07 | 浙江海洋大学 | A method of it is fermented using marine bacteria and prepares sponge acid |
| CN108949848B (en) * | 2018-08-08 | 2021-08-20 | 浙江海洋大学 | A kind of method utilizing marine bacteria fermentation to prepare sponge acid |
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