JPS57149288A - Imidazo(2,1-b)benzothiazole derivative - Google Patents
Imidazo(2,1-b)benzothiazole derivativeInfo
- Publication number
- JPS57149288A JPS57149288A JP56035718A JP3571881A JPS57149288A JP S57149288 A JPS57149288 A JP S57149288A JP 56035718 A JP56035718 A JP 56035718A JP 3571881 A JP3571881 A JP 3571881A JP S57149288 A JPS57149288 A JP S57149288A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- compound
- formula
- alkoxy
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RBQGKSWYSQGVDV-UHFFFAOYSA-N imidazo[2,1-b][1,3]benzothiazole Chemical class C1=CC=C2N3C=CN=C3SC2=C1 RBQGKSWYSQGVDV-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- GGRGGCMNHIYBDI-UHFFFAOYSA-N 6-ethoxyimidazo[2,1-b][1,3]benzothiazole-2-carboxylic acid Chemical compound CCOC1=CC=C2N3C=C(C(O)=O)N=C3SC2=C1 GGRGGCMNHIYBDI-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 hydroximino Chemical group 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
NEW MATERIAL:A compound of formulaI[one of R1WR6 is group of formula IV (X ia O, hydroximino; Y is H, hydroxyl, alkoxy, amino), the remainings are H, halogen, lower alkyl, alkoxy, hydroxyl, nitroso, nitro, amino, acylamino, mono-lower-alkyl amino]and its salt.
EXAMPLE: Etnyl 7-ethoxyimidazo[2, 1-b]benzothiazole-2-carboxylate.
USE: Antiallergic, antiasthmatic, anitrheumatic, carcinostatic and remedy for autoimmune diseases.
PREPARATION: The reaction between a compound of formula II[one of R11W R14 is group of formula V (Y1 is lower alkoxy, amino) or cyano, the remainings are H, halogen) and another compound of formula III (R9 is H, lower alkyl; R10 is lower alkyl) affords a compound of formulaIa.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56035718A JPS57149288A (en) | 1981-03-12 | 1981-03-12 | Imidazo(2,1-b)benzothiazole derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56035718A JPS57149288A (en) | 1981-03-12 | 1981-03-12 | Imidazo(2,1-b)benzothiazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57149288A true JPS57149288A (en) | 1982-09-14 |
Family
ID=12449632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56035718A Pending JPS57149288A (en) | 1981-03-12 | 1981-03-12 | Imidazo(2,1-b)benzothiazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57149288A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
| WO1998006724A1 (en) * | 1996-08-09 | 1998-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Metabotropic glutamate receptor agonists |
| EP0816366A4 (en) * | 1995-03-13 | 1998-07-08 | Nikken Chemicals Co Ltd | IMIDAZOTHIAZOL COMPOUNDS |
| EP2218464A1 (en) * | 2009-02-11 | 2010-08-18 | Technische Universität München | Compounds for non-invasive measurement of aggregates of amyloid peptides |
| US7820657B2 (en) | 2006-03-17 | 2010-10-26 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8883783B2 (en) | 2007-09-19 | 2014-11-11 | Ambit Biosciences Corporation | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
| JP2018503692A (en) * | 2015-02-03 | 2018-02-08 | アクティヴ・バイオテック・アーベー | Imidazo [2,1-b] thiazole and 5,6-dihydroimidazo [2,1-b] thiazole derivatives useful as S100 inhibitors |
-
1981
- 1981-03-12 JP JP56035718A patent/JPS57149288A/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
| EP0816366A4 (en) * | 1995-03-13 | 1998-07-08 | Nikken Chemicals Co Ltd | IMIDAZOTHIAZOL COMPOUNDS |
| US5919799A (en) * | 1995-03-13 | 1999-07-06 | Nikken Chemicals Co., Ltd. | Imidazothiazole compound |
| WO1998006724A1 (en) * | 1996-08-09 | 1998-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Metabotropic glutamate receptor agonists |
| US7820657B2 (en) | 2006-03-17 | 2010-10-26 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8129374B2 (en) | 2006-03-17 | 2012-03-06 | Ambit Bioscience Corporation | Method of using imidazolothiazole compounds for the treatment of disease |
| US8557810B2 (en) | 2006-03-17 | 2013-10-15 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8921546B2 (en) | 2006-03-17 | 2014-12-30 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| US8883783B2 (en) | 2007-09-19 | 2014-11-11 | Ambit Biosciences Corporation | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
| US9585892B2 (en) | 2007-09-19 | 2017-03-07 | Ambit Biosciences | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
| EP2218464A1 (en) * | 2009-02-11 | 2010-08-18 | Technische Universität München | Compounds for non-invasive measurement of aggregates of amyloid peptides |
| JP2018503692A (en) * | 2015-02-03 | 2018-02-08 | アクティヴ・バイオテック・アーベー | Imidazo [2,1-b] thiazole and 5,6-dihydroimidazo [2,1-b] thiazole derivatives useful as S100 inhibitors |
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