JPS5764617A - Cytotoxic proteinic complex and its preparation - Google Patents
Cytotoxic proteinic complex and its preparationInfo
- Publication number
- JPS5764617A JPS5764617A JP55139922A JP13992280A JPS5764617A JP S5764617 A JPS5764617 A JP S5764617A JP 55139922 A JP55139922 A JP 55139922A JP 13992280 A JP13992280 A JP 13992280A JP S5764617 A JPS5764617 A JP S5764617A
- Authority
- JP
- Japan
- Prior art keywords
- group
- ricin
- subunit
- immunoglobulin
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A cytotoxic proteinic complex expressed by formula I (Ab is immunoglobulin or a fragment thereof, RA is subunit A of ricin; X is bifuntional organic group; N in the amide bond is derived from the amino group in the immunoglobulin or a fragment thereof; S is derived from -SH group of the subunit A in ricin; n is an integer 0W10).
USE: A remedy for malignant tumors capable of exhibiting the cytotoxicity to the target cell, e.g. cancerous cell, selectively and efficiently.
PROCESS: A product obtained by reacting immunoglobulin or 1W10 amino groups in the gragment thereof with a compound expressed by formula II is reacted with the subunit A having -SH in the ricin. The active ester group in the compound expressed by formula II forms an amide group with the amino group in the immunoglobulin, and -SH group of the subunit A is then added to the double bond in the maleimido group to give the compound expressed by formulaI. The subunit A of the ricin is obtained by reducing the ricin, and separating the ricin into the subunits A and B.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55139922A JPS5764617A (en) | 1980-10-08 | 1980-10-08 | Cytotoxic proteinic complex and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55139922A JPS5764617A (en) | 1980-10-08 | 1980-10-08 | Cytotoxic proteinic complex and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5764617A true JPS5764617A (en) | 1982-04-19 |
Family
ID=15256774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55139922A Pending JPS5764617A (en) | 1980-10-08 | 1980-10-08 | Cytotoxic proteinic complex and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5764617A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6069033A (en) * | 1983-06-21 | 1985-04-19 | ザ・ボ−ド・オブ・リ−ジエンツ・ザ・ユニバ−シテイ・オブ・テキサス・システム | immunotoxin complex |
| JPS6112630A (en) * | 1984-06-20 | 1986-01-21 | サノフイ | Immunotoxin and its production method |
| JPS6156198A (en) * | 1984-05-23 | 1986-03-20 | サノフイ | Clathrate body coupled with ionophore and high molecule and use thereof |
| JPH06102679B2 (en) * | 1984-08-29 | 1994-12-14 | ダナ−ファ−バ− キャンサ− インスティテュ−ト，インコ−ポレイテッド | Acid-cleavable compound |
-
1980
- 1980-10-08 JP JP55139922A patent/JPS5764617A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6069033A (en) * | 1983-06-21 | 1985-04-19 | ザ・ボ−ド・オブ・リ−ジエンツ・ザ・ユニバ−シテイ・オブ・テキサス・システム | immunotoxin complex |
| JPS6156198A (en) * | 1984-05-23 | 1986-03-20 | サノフイ | Clathrate body coupled with ionophore and high molecule and use thereof |
| JPS6112630A (en) * | 1984-06-20 | 1986-01-21 | サノフイ | Immunotoxin and its production method |
| JPH06102679B2 (en) * | 1984-08-29 | 1994-12-14 | ダナ−ファ−バ− キャンサ− インスティテュ−ト，インコ−ポレイテッド | Acid-cleavable compound |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5686121A (en) | Antitumor proten complex and its preparation | |
| JPS5764617A (en) | Cytotoxic proteinic complex and its preparation | |
| DE3061127D1 (en) | Peptides having ubiquitin-like activity, process for their preparation, therapeutic compositions containing them and their use | |
| JPS51113841A (en) | Process for preparing lower alkyl esters of n-formyl-alpha -l-aspartyl-l-phenylalanine | |
| JPS55145665A (en) | Agent for forming active ester of amino acid | |
| JPS5225733A (en) | Process for preparation of benzaldehydes | |
| JPS51113870A (en) | A process for secretin synthesis | |
| JPS54128584A (en) | Novel 3,4-dihydrocarbostyril derivative | |
| JPS55112568A (en) | New oxo-barbituric acid derivative antigen and production | |
| JPS5420195A (en) | Preparation of guanosine-5'-monophosphoric acid | |
| JPS5430144A (en) | Preparation of isocamphane | |
| JPS5770854A (en) | N,n-dialkyl carbamate | |
| JPS5432417A (en) | Preparation of n,n-disubstituted glycol amide | |
| JPS5764695A (en) | Novel cephalotaxine derivative | |
| JPS5273888A (en) | Preparation of gamma-glutamic acid-n-carboxylic acid | |
| JPS5217486A (en) | Novel process for preparation of dibenzooxepine derivatives | |
| JPS51131847A (en) | Process for preparation of 2,2'- dithiobisbenzamide compounds | |
| JPS51136632A (en) | Process for preparation of dibenzamides | |
| JPS51139677A (en) | Process for cultivating methanol-assimilating microorganisms | |
| JPS51138608A (en) | Process for preparation of hexyne-3-ol | |
| JPS5253860A (en) | Synthesizing 5-aminoimidazole-4-carbonitrile | |
| JPS51138611A (en) | Process for preparation of delta- alkoxyl-alpha,beta-unsaturated aldehyde | |
| JPS5718664A (en) | N-substituted-bicyclo- 2.2.1 -hept-5-ene-2,3-dicarboximide derivative | |
| JPS52108089A (en) | Novel process for synthesis of peptide derivatives | |
| JPS56108772A (en) | Preparation of pyrimidine derivative containing amino group |