JPS63139562A - Hollow yarn type artificial lung - Google Patents
Hollow yarn type artificial lungInfo
- Publication number
- JPS63139562A JPS63139562A JP61286426A JP28642686A JPS63139562A JP S63139562 A JPS63139562 A JP S63139562A JP 61286426 A JP61286426 A JP 61286426A JP 28642686 A JP28642686 A JP 28642686A JP S63139562 A JPS63139562 A JP S63139562A
- Authority
- JP
- Japan
- Prior art keywords
- outlet
- heat exchange
- exchange medium
- hollow fibers
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004072 lung Anatomy 0.000 title description 8
- 239000012510 hollow fiber Substances 0.000 claims description 34
- 239000007789 gas Substances 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 16
- 210000004369 blood Anatomy 0.000 claims description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 13
- 230000004087 circulation Effects 0.000 claims description 13
- 239000001301 oxygen Substances 0.000 claims description 13
- 229910052760 oxygen Inorganic materials 0.000 claims description 13
- 238000005192 partition Methods 0.000 claims description 4
- 230000037452 priming Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、中空糸型人工肺に関する。さらに詳しくは熱
交換器を内蔵してなる中空糸型人工肺に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hollow fiber oxygenator. More specifically, the present invention relates to a hollow fiber oxygenator having a built-in heat exchanger.
［従来の技術］
関心術等において使用される人工肺には種々のタイプの
ものがあるが、近年になって中空糸型人工肺が開発され
使用が増加しつつある。人工肺を設けた体外循環回路に
は、血液を加温または冷却して体内へ返すために熱交換
器を設けるが、そのために体外循環回路全体の血液のプ
ライミング量はかなり多くなる。そこで、できるだけプ
ライミング量を減少させて患者への負担を少なくするた
めに、特開昭５８−８６１７１号公報及び特開昭５８−
１５５８６２号公報などにおいては、熱交換器を一体化
した人工肺が提案されている。[Prior Art] There are various types of oxygenators used in surgical procedures and the like, and hollow fiber oxygenators have been developed in recent years and are increasingly being used. Extracorporeal circulation circuits equipped with oxygenators are equipped with heat exchangers to warm or cool blood before returning it to the body, which increases the amount of blood priming throughout the extracorporeal circuit. Therefore, in order to reduce the amount of priming as much as possible and reduce the burden on the patient, Japanese Patent Laid-Open No. 58-86171 and Japanese Patent Laid-Open No. 58-58
In Japanese Patent No. 155862 and the like, an artificial lung with an integrated heat exchanger has been proposed.
［発明が解決しようとする問題点］
上記の熱交換器一体型人工肺は、プライミング量を減少
させる上である程度の効果はあるが、効果の程度は小さ
い。なぜなら、プライミング量の減少は単に人工肺と熱
交換器を連結して回路を簡略化したことによるものにす
ぎず、一体化した装置自身のプライミング量は従来の分
離型装置のプライミング量の和と変わらないからである
。[Problems to be Solved by the Invention] Although the heat exchanger-integrated oxygenator described above has some effect in reducing the amount of priming, the degree of effect is small. This is because the reduction in priming amount is simply due to the simplification of the circuit by connecting the oxygenator and heat exchanger, and the priming amount of the integrated device itself is equal to the sum of the priming amount of the conventional separate device. Because it doesn't change.
本発明の目的は、回路の簡略化によるブライミング量の
減少にとどまらず、人工肺と熱交換器とを複合化して大
幅にブライミング量を減少させた熱交換器一体型人工肺
を提供することにある。The purpose of the present invention is not only to reduce the amount of briming by simplifying the circuit, but also to provide an oxygenator with an integrated heat exchanger that combines an oxygenator and a heat exchanger to significantly reduce the amount of briming. be.
［問題を解決するための手段］
本発明の人工肺は、人工肺と熱交換器とを複合的に一体
化したものであり、これによって初めてプライミング量
の大幅な減少が可能になった。本発明の人工肺は、血液
導出入口、酸素含有ガス導出入口及び熱交換媒体導出入
口を有するハウジングと、該ハウジング内のほぼ中央に
設けられた熱交換媒体流通部と、該熱交換媒体流通部を
取り巻くように配置された多数のガス透過性中空糸と、
該中空糸を両端で保持するとともに中空糸の内部と外部
とを隔離する隔壁とを有してなり、前記血液導出入口と
中空糸外部とを連通し酸素含有ガス導出入口と中空糸内
部とを連通してなる構造を有するものである。すなわち
、中心部に熱交換器を設けこれを取り巻くように中空糸
を配置し、血液を中空糸の外部に流すとともに酸素含有
ガスを中空系の内部に流すようにしたものである。[Means for Solving the Problems] The oxygenator of the present invention has an oxygenator and a heat exchanger integrated in a complex manner, and this makes it possible for the first time to significantly reduce the amount of priming. The artificial lung of the present invention includes a housing having a blood lead-in/outlet, an oxygen-containing gas lead-in/outlet, and a heat exchange medium lead-in/out port, a heat exchange medium circulation part provided approximately at the center of the housing, and the heat exchange medium circulation part. A large number of gas-permeable hollow fibers arranged to surround the
It has a partition wall that holds the hollow fiber at both ends and isolates the inside and outside of the hollow fiber, and connects the blood outlet and outlet to the outside of the hollow fiber and connects the oxygen-containing gas outlet and outlet to the inside of the hollow fiber. It has a structure in which it is connected. That is, a heat exchanger is provided in the center, and hollow fibers are arranged to surround it, so that blood flows outside the hollow fibers and oxygen-containing gas flows inside the hollow system.
［作 用］
本発明の人工肺においては、ハウジング内に導入された
血液は、熱交換媒体流通部外表面と接触して加温または
冷却され、さらに中空糸外表面と接触して中空糸内部を
流れる酸素含有ガスとの間でガス交換が行われる。[Function] In the artificial lung of the present invention, the blood introduced into the housing is heated or cooled by contacting the outer surface of the heat exchange medium circulation section, and further contacts the outer surface of the hollow fibers and flows inside the hollow fibers. Gas exchange takes place with the oxygen-containing gas flowing through.
［実施例］ 以下、図面により本発明をさらに具体的に説明する。[Example] Hereinafter, the present invention will be explained in more detail with reference to the drawings.
第１図は本発明の中空糸型人工肺の実施例についての縦
断面図であり、第２図は横断面図である。FIG. 1 is a longitudinal cross-sectional view of an embodiment of the hollow fiber oxygenator of the present invention, and FIG. 2 is a cross-sectional view.
すなわち第１図の線■−■の位置で切断したのが第２図
であり、第２図の線Ｉ−Ｉの位置で切断したのが第１図
である。人工肺は円筒型のハウジング１内に多数のガス
透過性中空糸６と熱交換媒体流通部７とが収納された構
造になっている。ハウジング１は合成樹脂で形成されて
おり、第１図において図の下方中央部に血液導入口９を
有し、左右側面に２つの血液導出口５，５を有している
。That is, FIG. 2 is a cut along line 1--2 in FIG. 1, and FIG. 1 is a cut along line I--I in FIG. The oxygenator has a structure in which a large number of gas-permeable hollow fibers 6 and a heat exchange medium circulation section 7 are housed in a cylindrical housing 1. The housing 1 is made of synthetic resin, and in FIG. 1 has a blood inlet 9 in the lower central part of the figure and two blood outlet ports 5, 5 on the left and right sides.
また、図の上方には酸素含有ガス導入口２が、下方には
酸素含有ガス導出口１０が設けられており、さらに上方
中央部付近には熱交換媒体導入口３と導出口４が設けら
れている。ハウジング１内のほぼ中央には熱交換媒体流
通部７が設けられているが、７はアルミニウムやステン
レス等から形成された中空円筒体であり、第２図より明
らかなように、側面にひだを設けて表面積を増加させる
とともに血液の流路を確保している。Further, an oxygen-containing gas inlet 2 is provided at the top of the figure, an oxygen-containing gas outlet 10 is provided at the bottom, and a heat exchange medium inlet 3 and an outlet 4 are provided near the upper center. ing. A heat exchange medium circulation part 7 is provided approximately in the center of the housing 1, and 7 is a hollow cylindrical body made of aluminum, stainless steel, etc., and as is clear from FIG. This increases the surface area and ensures a blood flow path.
中空糸６は内径１００〜１０００μ、厚さ５０〜２００
μ程度の中空糸を多数本集束または積層したものであり
、両端において隔壁１１．１１によって接着固定されて
いる。中空糸は非多孔質のシリコーンゴムあるいは多孔
質ポリエチレンまたはポリプロピレンなどから形成され
たものが好ましく使用される。中空糸はハウジングの軸
方向に平行に束ねたものでもよいが、斜め方向に１層ず
つ互いに交差するように積層したものでもよい。The hollow fiber 6 has an inner diameter of 100 to 1000μ and a thickness of 50 to 200μ.
It is made by bundling or laminating a large number of hollow fibers of μ size, and is adhesively fixed at both ends by partition walls 11 and 11. The hollow fibers are preferably made of non-porous silicone rubber or porous polyethylene or polypropylene. The hollow fibers may be bundled parallel to the axial direction of the housing, or may be stacked diagonally one layer at a time so as to cross each other.
斜め方向に積層する場合には、中空糸を熱交換媒体流通
部７の周囲に巻いていくことによって容易に中空糸層を
形成することができるので便利である。隔壁１１は、中
空糸の端部を接着固定するためにポリウレタン等の液状
硬化性樹脂を遠心注型して形成したものであり、中空糸
内腔は両端において開口している。When laminated in an oblique direction, it is convenient because the hollow fiber layer can be easily formed by winding the hollow fibers around the heat exchange medium circulation section 7. The partition wall 11 is formed by centrifugally casting a liquid hardening resin such as polyurethane to adhesively fix the ends of the hollow fibers, and the hollow fiber lumen is open at both ends.
次に、人工肺の機能について説明する。酸素含有ガスは
導入口２よりハウジング内に導入し、第１図の上方端部
より中空糸内へ供給する。そして中空糸の内部を通過し
たガスは下方の端部より排出され、１０より外部へ導出
される。また、熱交換媒体導入口３から温水などの熱交
換媒体を導入し、７内を流通させた後導出口４より排出
させる。Next, the function of the artificial lung will be explained. The oxygen-containing gas is introduced into the housing through the inlet 2 and supplied into the hollow fiber from the upper end in FIG. The gas that has passed through the inside of the hollow fiber is discharged from the lower end and led out from 10. In addition, a heat exchange medium such as hot water is introduced from the heat exchange medium inlet 3 and is allowed to flow through the interior of the heat exchange medium 7 before being discharged from the outlet 4.
血液は導入口９よりハウジング内に導入すると熱交換媒
体流通部７の外表面と接触し、ひだ８によって整流され
ると同時に熱交換が行われて加温または冷却され、中空
糸の間へ入って行く。そして中空糸の内部を流れる酸素
含有ガスとの間でガス交換が行われ、酸素加されて導出
口５より導出される。このようにして血液は本発明の人
工肺を通過する間に酸素加と熱交換の両方が行われる。When blood is introduced into the housing through the inlet 9, it comes into contact with the outer surface of the heat exchange medium flow section 7, is rectified by the folds 8, heat exchanges at the same time, and is heated or cooled, and then enters between the hollow fibers. Go. Then, gas exchange is performed with the oxygen-containing gas flowing inside the hollow fibers, oxygen is added thereto, and the gas is discharged from the outlet 5. In this way, blood is both oxygenated and heat exchanged while passing through the oxygenator of the invention.
しかも熱交換媒体流通部を設けたことによって、血液が
プライミングされる部分に全く無駄がなくなり、プライ
ミング量を飛躍的に少なくできた。Moreover, by providing the heat exchange medium circulation section, there is no waste in the area where blood is primed, and the amount of priming can be dramatically reduced.
［発明の効果］
本発明の人工肺は、熱交換器を複合一体化したことによ
り体外循環回路全体としての血液のプライミング量が大
幅に減少し、患者に対する負担を少なくすることができ
る。また、好ましい態様においては熱交換媒体流通部の
側面にひだを設けたことにより、伝熱面積を大きくとる
ことができるだけでなく血液がひだに沿って中空糸全体
に均一に分配されて流れるので、ガス交換効率の優れた
人工肺が得られる。[Effects of the Invention] In the artificial lung of the present invention, by integrating the heat exchanger into a composite body, the amount of blood priming for the whole extracorporeal circulation circuit is significantly reduced, and the burden on the patient can be reduced. In addition, in a preferred embodiment, by providing pleats on the side surface of the heat exchange medium circulation section, not only can the heat transfer area be increased, but also blood can flow uniformly throughout the hollow fibers along the pleats. An artificial lung with excellent gas exchange efficiency can be obtained.
第１図は本発明の人工肺の実施例についての縦断面図で
あり、第２図は横断面図である。
１、ハウジング ２．酸素含有ガス導入口３、熱
交換媒体導入口 ４．熱交換媒体導出口５、血液導出口
６．中空糸
７、熱交換媒体流通部 ８．ひだ
９、血液導入口 １０．酸素含有ガス導出口１１、
隔壁FIG. 1 is a longitudinal cross-sectional view of an embodiment of the artificial lung of the present invention, and FIG. 2 is a cross-sectional view. 1. Housing 2. Oxygen-containing gas inlet 3, heat exchange medium inlet 4. Heat exchange medium outlet 5, blood outlet 6. Hollow fiber 7, heat exchange medium distribution part 8. Fold 9, blood inlet 10. oxygen-containing gas outlet 11;
bulkhead
Claims (1)
出入口を有するハウジングと、該ハウジング内のほぼ中
央に設けられた熱交換媒体流通部と、該熱交換媒体流通
部を取り巻くように配置された多数のガス透過性中空糸
と、該中空糸を両端で保持するとともに中空糸の内部と
外部とを隔離する隔壁とを有してなり、前記血液導出入
口と中空糸外部とを連通し酸素含有ガス導出入口と中空
糸内部とを連通してなる構造を有することを特徴とする
中空糸型人工肺。A housing having a blood inlet/outlet, an oxygen-containing gas inlet/outlet, and a heat exchange medium inlet/outlet, a heat exchange medium circulation section provided approximately at the center of the housing, and a heat exchange medium circulation section arranged so as to surround the heat exchange medium circulation section. It has a large number of gas-permeable hollow fibers, and a partition wall that holds the hollow fibers at both ends and isolates the inside and outside of the hollow fibers, and communicates the blood inlet/outlet with the outside of the hollow fibers to contain oxygen. A hollow fiber oxygenator characterized by having a structure in which a gas inlet/outlet and the inside of the hollow fiber are connected to each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61286426A JPS63139562A (en) | 1986-12-01 | 1986-12-01 | Hollow yarn type artificial lung |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61286426A JPS63139562A (en) | 1986-12-01 | 1986-12-01 | Hollow yarn type artificial lung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63139562A true JPS63139562A (en) | 1988-06-11 |
Family
ID=17704235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61286426A Pending JPS63139562A (en) | 1986-12-01 | 1986-12-01 | Hollow yarn type artificial lung |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63139562A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6440060A (en) * | 1987-08-06 | 1989-02-10 | Ube Industries | Artificial lung provided with built-in heat exchanger |
| US5120501A (en) * | 1988-10-20 | 1992-06-09 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
| US5225161A (en) * | 1988-10-20 | 1993-07-06 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
| JP2015144857A (en) * | 2011-05-17 | 2015-08-13 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | Blood processing unit having blood cross flow |
| US9402943B2 (en) | 2010-08-19 | 2016-08-02 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US10098994B2 (en) | 2014-01-09 | 2018-10-16 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| US10369262B2 (en) | 2014-02-28 | 2019-08-06 | Sorin Group Italia S.R.L. | System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume |
| US10661004B2 (en) | 2015-05-12 | 2020-05-26 | Sorin Group Italia S.R.L. | Blood gas exchanger with restriction element or elements to reduce gas exchange |
| US10814056B2 (en) | 2014-11-12 | 2020-10-27 | Sorin Group Italia S.R.L. | Elastic protection tube for a hollow fiber blood processing apparatus |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4922437A (en) * | 1972-06-22 | 1974-02-27 |
-
1986
- 1986-12-01 JP JP61286426A patent/JPS63139562A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4922437A (en) * | 1972-06-22 | 1974-02-27 |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6440060A (en) * | 1987-08-06 | 1989-02-10 | Ube Industries | Artificial lung provided with built-in heat exchanger |
| US5120501A (en) * | 1988-10-20 | 1992-06-09 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
| US5225161A (en) * | 1988-10-20 | 1993-07-06 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
| JPH0622620B2 (en) * | 1988-10-20 | 1994-03-30 | バクスター インターナショナル インコーポレーテッド | Integrated blood membrane oxygenator / heat exchanger |
| US11160912B2 (en) | 2010-08-19 | 2021-11-02 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US9402943B2 (en) | 2010-08-19 | 2016-08-02 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US10159777B2 (en) | 2010-08-19 | 2018-12-25 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| US12171923B2 (en) | 2010-08-19 | 2024-12-24 | Sorin Group Italia S.R.L. | Blood processing unit with modified flow path |
| JP2015144857A (en) * | 2011-05-17 | 2015-08-13 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | Blood processing unit having blood cross flow |
| US10098994B2 (en) | 2014-01-09 | 2018-10-16 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| USRE49759E1 (en) | 2014-01-09 | 2023-12-19 | Sorin Group Italia S.R.L. | Blood processing unit with heat exchanger core for providing modified flow path |
| US10369262B2 (en) | 2014-02-28 | 2019-08-06 | Sorin Group Italia S.R.L. | System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume |
| US11471577B2 (en) | 2014-02-28 | 2022-10-18 | Sorin Group S.r.l. | System for providing an integrated arterial filter into an oxygenator, minimizing added priming volume |
| US10814056B2 (en) | 2014-11-12 | 2020-10-27 | Sorin Group Italia S.R.L. | Elastic protection tube for a hollow fiber blood processing apparatus |
| US12053565B2 (en) | 2015-05-12 | 2024-08-06 | Sorin Group Italia S.R.L. | Blood gas exchanger with restriction element or elements to reduce gas exchange |
| US10661004B2 (en) | 2015-05-12 | 2020-05-26 | Sorin Group Italia S.R.L. | Blood gas exchanger with restriction element or elements to reduce gas exchange |
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