[go: up one dir, main page]

KR100459984B1 - 에리트로포이에틴수용체(epo-r)에결합하는화합물및펩티드 - Google Patents

에리트로포이에틴수용체(epo-r)에결합하는화합물및펩티드 Download PDF

Info

Publication number
KR100459984B1
KR100459984B1 KR1019970709231A KR19970709231A KR100459984B1 KR 100459984 B1 KR100459984 B1 KR 100459984B1 KR 1019970709231 A KR1019970709231 A KR 1019970709231A KR 19970709231 A KR19970709231 A KR 19970709231A KR 100459984 B1 KR100459984 B1 KR 100459984B1
Authority
KR
South Korea
Prior art keywords
peptide
epo
amino acid
peptides
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019970709231A
Other languages
English (en)
Korean (ko)
Other versions
KR19990022656A (ko
Inventor
씨. 라이튼 니콜라스
제이. 도워 윌리엄
에스. 창 레이
케이. 케쉬얍 아런
케이. 졸리프 린다
존슨 다나
멀케히 린다
Original Assignee
아피맥스 테크놀로지스, 엔.브이.
오르토 파마슈티칼 코오포레이숀
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/484,635 external-priority patent/US5773569A/en
Priority claimed from US08/484,631 external-priority patent/US5830851A/en
Application filed by 아피맥스 테크놀로지스, 엔.브이., 오르토 파마슈티칼 코오포레이숀 filed Critical 아피맥스 테크놀로지스, 엔.브이.
Publication of KR19990022656A publication Critical patent/KR19990022656A/ko
Application granted granted Critical
Publication of KR100459984B1 publication Critical patent/KR100459984B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/505Erythropoietin [EPO]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019970709231A 1995-06-07 1996-06-07 에리트로포이에틴수용체(epo-r)에결합하는화합물및펩티드 Expired - Fee Related KR100459984B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/484,635 US5773569A (en) 1993-11-19 1995-06-07 Compounds and peptides that bind to the erythropoietin receptor
US08/484,631 US5830851A (en) 1993-11-19 1995-06-07 Methods of administering peptides that bind to the erythropoietin receptor
US08/484635 1995-06-07
US8/484631 1995-06-07
US08/484631 1995-06-07
US8/484635 1995-06-07

Publications (2)

Publication Number Publication Date
KR19990022656A KR19990022656A (ko) 1999-03-25
KR100459984B1 true KR100459984B1 (ko) 2005-06-20

Family

ID=27048076

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970709231A Expired - Fee Related KR100459984B1 (ko) 1995-06-07 1996-06-07 에리트로포이에틴수용체(epo-r)에결합하는화합물및펩티드

Country Status (18)

Country Link
EP (2) EP0886648B8 (fr)
JP (3) JP4050314B2 (fr)
KR (1) KR100459984B1 (fr)
CN (1) CN1192748A (fr)
AT (1) ATE254138T1 (fr)
AU (1) AU712713B2 (fr)
BR (1) BR9609006A (fr)
CA (1) CA2223833C (fr)
CZ (1) CZ391097A3 (fr)
DE (1) DE69630708T2 (fr)
ES (1) ES2210374T3 (fr)
HU (1) HUP9901069A2 (fr)
IL (1) IL122417A0 (fr)
NO (1) NO318783B1 (fr)
NZ (1) NZ310804A (fr)
PL (1) PL185040B1 (fr)
TR (1) TR199701557T2 (fr)
WO (1) WO1996040749A1 (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830851A (en) * 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5773569A (en) * 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5767078A (en) * 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
US6121416A (en) * 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
DE19904396A1 (de) * 1999-02-04 2000-08-10 Bayer Ag Substituierte Pyrazolbenzylamin-Derivate
DE19904406A1 (de) * 1999-02-04 2000-08-10 Bayer Ag Substituierte Pyrazolcarbonsäuren
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6703480B1 (en) 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
US7259146B2 (en) 2000-05-26 2007-08-21 Ortho-Mcneil Pharmaceutical, Inc. Neuroprotective peptides
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
EP1581260B1 (fr) 2002-12-31 2014-09-17 Nektar Therapeutics Reactifs polymeres comprenant une cetone ou un groupe fonctionnel apparente
NZ543935A (en) 2003-05-12 2008-06-30 Affymax Inc Peptides that bind to the erythropoietin receptor
JP2007500218A (ja) 2003-05-12 2007-01-11 アフィーマックス・インコーポレイテッド ポリ(エチレングリコール)修飾ペプチド系化合物の新規スペーサー部分
SG160224A1 (en) 2003-05-12 2010-04-29 Affymax Inc Novel peptides that bind to the erythropoietin receptor
CN1820024B (zh) 2003-05-12 2011-06-22 阿费麦克斯公司 新的聚(乙二醇)修饰的化合物及其用途
US7887789B2 (en) 2003-05-23 2011-02-15 Nektar Therapeutics Polymer derivatives having particular atom arrangements
WO2005028539A2 (fr) 2003-09-17 2005-03-31 Nektar Therapeutics Al, Corporation Promedicaments a base de polymere a branches multiples
EA018427B1 (ru) 2003-12-16 2013-07-30 Нектар Терапьютикс Химически модифицированный налоксон
DE602005012575D1 (en) * 2004-03-17 2009-03-19 Aplagen Gmbh Isostere transformation
US8562965B2 (en) 2004-05-03 2013-10-22 Nektar Therapeutics Polymer derivatives comprising an acetal or ketal branching point
WO2005107815A2 (fr) 2004-05-03 2005-11-17 Nektar Therapeutics Al, Corporation Dérivés de polymères comprenant un point de ramification de type imide
AU2005303887A1 (en) * 2004-11-10 2006-05-18 Aplagen Gmbh Molecules which promote hematopoiesis
US7589063B2 (en) 2004-12-14 2009-09-15 Aplagen Gmbh Molecules which promote hematopoiesis
WO2006060148A2 (fr) * 2004-11-11 2006-06-08 Affymax, Inc. Nouveaux peptides qui se lient au recepteur d'erythropoietine
CN101198321A (zh) * 2005-04-26 2008-06-11 味之素株式会社 骨髓祖红细胞分化诱导剂
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
EA200800109A1 (ru) * 2005-06-23 2008-06-30 Аплаген Гмбх Суправалентные соединения
EP2371855B1 (fr) * 2005-08-05 2015-07-22 Araim Pharmaceuticals, Inc. Peptides protecteurs de tissus et utilisations associées
CA2680228A1 (fr) * 2006-03-09 2007-09-13 Aplagen Gmbh Molecules modifiees destinees a promouvoir l'hematopoiese
US8470963B2 (en) 2006-06-30 2013-06-25 Sku Asset Management Gmbh Multifunctional compounds for pharmaceutical purposes
WO2008095004A2 (fr) 2007-01-31 2008-08-07 Affymax, Inc. Groupements de liaison à base d'azote destinés à attacher des groupements modificateurs à des polypeptides et autres macromolécules
EP2018835B1 (fr) 2007-07-09 2014-03-05 Augustinus Bader Pavé sortant d'agent actif
CN101456911A (zh) * 2007-12-12 2009-06-17 江苏豪森药业股份有限公司 促红细胞生成素模拟肽衍生物及其可药用盐和其制备方法与用途
WO2009142679A2 (fr) * 2008-03-26 2009-11-26 Orthologic Corp. Procédés permettant de traiter un infarctus du myocarde aigu
US8575102B2 (en) 2008-08-01 2013-11-05 Nektar Therapeutics Conjugates having a releasable linkage
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
EP2331139B1 (fr) 2008-09-11 2019-04-17 Nektar Therapeutics Réactifs polymères alpha-hydroxy aldéhydiques et cétoniques et procédé de conjugaison
MX2011003117A (es) 2008-09-19 2011-04-21 Nektar Therapeutics Conjugados polimericos de peptidos terapeuticos.
WO2010036964A2 (fr) * 2008-09-26 2010-04-01 Ambrx Inc. Polypeptides d'érythropoïétine animale modifiés et leurs utilisations
JP6059014B2 (ja) * 2009-06-19 2017-01-11 アリゾナ ボード オブ リージェンツ ア ボディー コーポレート アクティング オン ビハーフ オブ アリゾナ ステイト ユニバーシティARIZONA BOARD OF REGENTS,a body corporate acting on behalf of ARIZONA STATE UNIVERSITY 試料の構成成分の検出において使用されるデバイスを製造する方法およびペプチドアレイ
WO2011012306A2 (fr) 2009-07-30 2011-02-03 Aplagen Gmbh Utilisation d'emp pour contrer les effets stimulants de l'epo sur des tumeurs sensibles à l'epo, tout en maintenant l'érythropoïèse
ES2632164T3 (es) 2010-07-06 2017-09-11 Augustinus Bader Aplicación tópica de eritropoyetina para uso en el tratamiento de lesiones de la córnea
WO2012088422A1 (fr) 2010-12-22 2012-06-28 Nektar Therapeutics Conjugués promédicaments polymères à plusieurs bras de composés à base de taxane
WO2012088445A1 (fr) 2010-12-22 2012-06-28 Nektar Therapeutics Conjugués promédicaments polymères à plusieurs bras de composés à base de cabazitaxel
WO2012166555A1 (fr) 2011-05-27 2012-12-06 Nektar Therapeutics Composés à base de médicament et de fraction de liaison liée à un polymère soluble dans l'eau
WO2013171810A1 (fr) 2012-05-14 2013-11-21 パナソニック株式会社 Procédé d'obtention d'un phage présentateur d'anticorps thermorésistant
CN103450348B (zh) * 2012-05-29 2016-03-30 中国人民解放军军事医学科学院毒物药物研究所 一种促红细胞生成素模拟肽、其制备方法和用途
CN106608906A (zh) * 2015-10-22 2017-05-03 天津药物研究院有限公司 一种具有刺激红细胞生成功能的环形多肽的制备及其应用
CN106928338A (zh) * 2015-12-31 2017-07-07 杭州阿德莱诺泰制药技术有限公司 促红细胞生成素肽及衍生物和聚合物、制备方法和应用
GB201609083D0 (en) 2016-05-24 2016-07-06 Syntab Therapeutics Gmbh Synthetic compound
JP7445978B2 (ja) * 2018-09-14 2024-03-08 エポメッド株式会社 抗エリスロポエチン受容体ペプチド
AU2020292266A1 (en) 2019-06-10 2022-01-27 Respira Therapeutics, Inc. Carrier-based formulations and related methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008822A1 (fr) * 1989-02-03 1990-08-09 Genetics Institute, Inc. Recepteur d'erythropoietine
US5106954A (en) * 1989-07-26 1992-04-21 Behringwerke Aktiengesellschaft Erythropoietin (epo) peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US5767078A (en) * 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008822A1 (fr) * 1989-02-03 1990-08-09 Genetics Institute, Inc. Recepteur d'erythropoietine
US5106954A (en) * 1989-07-26 1992-04-21 Behringwerke Aktiengesellschaft Erythropoietin (epo) peptides

Also Published As

Publication number Publication date
DE69630708D1 (de) 2003-12-18
AU6166796A (en) 1996-12-30
BR9609006A (pt) 1999-12-14
JPH11507367A (ja) 1999-06-29
CA2223833A1 (fr) 1996-12-19
EP0886648A4 (fr) 2000-01-12
KR19990022656A (ko) 1999-03-25
PL323858A1 (en) 1998-04-27
JP2007277264A (ja) 2007-10-25
AU712713B2 (en) 1999-11-11
NZ310804A (en) 1998-10-28
ATE254138T1 (de) 2003-11-15
NO975729D0 (no) 1997-12-05
EP1510524A2 (fr) 2005-03-02
PL185040B1 (pl) 2003-02-28
CA2223833C (fr) 2010-12-21
EP0886648B8 (fr) 2004-03-03
JP4050314B2 (ja) 2008-02-20
ES2210374T3 (es) 2004-07-01
EP1510524A3 (fr) 2006-06-07
DE69630708T2 (de) 2004-08-05
NO975729L (no) 1998-02-05
EP0886648B1 (fr) 2003-11-12
NO318783B1 (no) 2005-05-09
JP2009280616A (ja) 2009-12-03
CN1192748A (zh) 1998-09-09
HUP9901069A2 (hu) 1999-07-28
EP0886648A1 (fr) 1998-12-30
WO1996040749A1 (fr) 1996-12-19
CZ391097A3 (cs) 1998-07-15
TR199701557T2 (xx) 2002-06-21
IL122417A0 (en) 1998-06-15

Similar Documents

Publication Publication Date Title
KR100459984B1 (ko) 에리트로포이에틴수용체(epo-r)에결합하는화합물및펩티드
US5830851A (en) Methods of administering peptides that bind to the erythropoietin receptor
US5773569A (en) Compounds and peptides that bind to the erythropoietin receptor
AU2004238868B2 (en) Peptides that bind to the erythropoietin receptor
AU2004238870B2 (en) Novel peptides that bind to the erythropoietin receptor
US20130012685A1 (en) Novel peptides that bind to the erythropoietin receptor
US20120157660A1 (en) Novel peptides that bind to the erythropoietin receptor
HK1088906B (en) Peptides that bind to the erythropoietin receptor

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

FPAY Annual fee payment

Payment date: 20121031

Year of fee payment: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

FPAY Annual fee payment

Payment date: 20131031

Year of fee payment: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20141126

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20141126