KR100759518B1 - Oral composition for bad breath - Google Patents

Abstract

The present invention relates to an oral composition for inhibiting bad breath, and more particularly, to an oral composition for inhibiting bad breath comprising an acidic first agent and a basic second agent. When the acidic first preparation and the basic second preparation are used in a ratio of about 1: 1, the proliferation of bad breath-causing microorganisms at various pH conditions can be suppressed, thereby providing an excellent effect of preventing and inhibiting detention. It does not cause side effects such as discoloration of teeth.

Bad breath, microorganisms, pH, acids, bases

Description

Oral composition for suppressing bad breath {Oral Composition for suppressing oral malodor}

The present invention relates to an oral composition for inhibiting bad breath, and more particularly, it consists of an acidic first agent and a basic second agent, and when used, it is blended in a ratio of about 1: 1, thereby providing an excellent bad breath preventing and suppressing effect. It relates to an oral composition for inhibiting bad breath that can be provided.

In general, bad breath is caused by acquired systemic diseases, proteins in the saliva, food residues, etc., are broken down by microorganisms in the oral cavity, and amino acids are decomposed by dehydrating enzymes or amino enzymes to produce odor-causing substances. This is caused by the bad breath causing substances such as volatile sulfide compounds (VSC), such as hydrogen sulfide (H ₂ S), methyl mercaptan (CH ₃ SH), dimethyl mercaptan [(CH ₃ ) ₂ S] Amine compounds, aldehydes, fatty acids, ammonia, pyridine and the like. In addition, when ingesting garlic or red pepper, bad breath is also caused by sulfides contained in these substances.

Therefore, in order to prevent or inhibit bad breath in the oral cavity, it is necessary to remove the causative agents causing bad breath or to suppress the growth of microorganisms in the oral cavity, which is the primary cause of bad breath, and conventionally, bamboo salt, green tea flavono component, persimmon leaf extract, etc. The use of oral antimicrobial agents such as triclosan, chlorohexidine hydrochloride, or the like to remove volatile sulfur compounds has been used to remove or prevent bad breath causing microorganisms.

However, the method of removing the substance causing bad breath was a problem that can prevent and suppress bad breath in the short term, but because the microorganism which is the primary cause of bad breath is present in the oral cavity, the long term effect cannot be sustained.

In addition, the method of removing the microorganisms causing bad breath cause different microorganisms that can inhibit the growth of microorganisms causing bad breath. Therefore, it is not easy to select a suitable antimicrobial agent and some side effects such as discoloration of teeth depending on the antimicrobial agents. There was a problem that caused it.

Accordingly, the present inventors have repeatedly studied to develop oral hygiene products that can effectively prevent and suppress bad breath by inhibiting the proliferation of various bad breath-causing microorganisms without side effects. If the composition is composed of a basic second agent, and used in a ratio of about 1: 1, all acidic, basic and neutral pHs exist in the oral cavity, and the pH conditions for inhibiting proliferation differ depending on the type of bad breath causing microorganism. The present invention has been found to be able to satisfy all of them to provide an excellent bad breath prevention and suppression effect, does not cause side effects such as discoloration of teeth and has completed the present invention.

Accordingly, it is an object of the present invention to provide an oral composition for inhibiting bad breath, which exhibits an excellent bad breath prevention and suppression effect by simply inhibiting the proliferation of various bad breath causing microorganisms without side effects.

In order to achieve the above object, oral composition for inhibiting bad breath according to the present invention is composed of an acidic first agent and a basic second agent, characterized in that used in combination of about 1: 1.

Hereinafter, the present invention will be described in more detail.

The oral composition of this invention consists of an acidic 1st agent and a basic 2nd agent, It is characterized by using these in combination of about 1: 1.

That is, the present inventors are different from the following facts that the range of effective pH that can suppress their proliferation by each bad breath-causing microorganism, in order to effectively inhibit bad breath pH in the oral cavity is effective pH for inhibiting the growth of these bad breath-causing microorganisms Found that all ranges must be met;

Hereinafter, the characteristics of oral bad breath-causing microorganisms and mechanisms thereof will be described in detail.

First, bad breath in the oral cavity is Fusobacterium nucleatum , Veionella alcalescens , Porphyromonas gingivalis , and Prebo , which grow in a wide range of pH. It is caused by microorganisms such as Prevotella intermedia , Prevotella loeschii , Treponema denticola , Klebsiella pneumonieae .

Second, even if a human eats food containing a large number of germs or microorganisms, the disease is not infected because most of the germs or microorganisms in the stomach die from strong acidic acid at pH 2 to 3 in the stomach. This can be suppressed.

Third, saliva can inhibit the growth of microorganisms, the pH of which is 7. Fourth, chlorophyll, DNA, and ATP of microorganisms are decomposed under acidic conditions, and RNA and phospholipids are decomposed under alkaline conditions.

Accordingly, the present inventors have proposed an oral composition of the present invention consisting of an acidic first agent and a basic second agent based on the above facts. Acidic portion of the formulation; A neutral moiety in which the first agent and the second agent react (approximately the intermediate pH of the first agent and the basic pH of the second agent); And since the basic portion of the second agent is present to satisfy the effective pH for inhibiting the proliferation of various bad breath-causing microorganisms, it was confirmed that the growth of many kinds of bad breath-causing microorganisms is suppressed.

In the oral composition of the present invention, the acidic first agent is a pH adjusted to 2 to 7 using an acidic pH adjuster. At this time, the reason why the pH of the first formulation is 2 or more is because when the pH is less than 2, it may cause corrosion of the hard tissue of the tooth.

The acidic pH adjuster used in the present invention is used in a normal oral composition, and the kind thereof is not particularly limited, but citric acid, tartaric acid, boric acid, phosphoric acid, hydrochloric acid and the like can be used.

On the other hand, a basic 2nd agent adjusts pH to 7-12 using a basic pH adjuster. At this time, the reason why the pH is 12 or less is because when the pH exceeds 12, it can damage the teeth and gums.

The basic pH adjuster used in the present invention is used in a conventional oral composition, and the kind is not limited, and sodium monophosphate, sodium diphosphate, trisodium phosphate, sodium citrate, sodium stannate, sodium hydroxide, hydroxide Potassium, calcium hydroxide, sodium pyrophosphate, calcium pyrophosphate, ethylenediaminetetraacetate disodium (EDTA 2Na) and the like can be used.

In the oral composition of the present invention, the first agent and the second agent have a paste, liquid or tablet form, and the first agent and the second agent should be in the same form.

When the first agent and the second agent are paste or liquid, each agent is stored in a double container with a diaphragm or in a separate container so that they are mixed and reacted only when used. In the double container with the diaphragm, the first agent and the second agent should be discharged in the same amount.

On the other hand, a double container that can be used for this purpose is not particularly limited as long as it can achieve the above object, it is preferable to use the discharge container of the paste disclosed in Korea Patent Publication No. 2003-60753.

In the oral composition of the present invention, when the first agent and the second agent are in tablet form, they are dissolved in water immediately before each tablet is used, and then these solutions are formulated in a ratio of about 1: 1 and applied to the oral cavity. At this time, the amount of dissolving the first agent and the second agent in water is not particularly limited, but it is preferable to dissolve 0.01 to 5 g of the tablet formulation in 1 to 2,000 ml of drinking water.

On the other hand, as described above, when the acidic first agent and basicity are mixed in the same amount and applied to the oral cavity, the acidic pH of the first agent, the basic pH of the second agent, the first agent and the second agent react. Since a neutral pH is present in the oral cavity, and various pH conditions that can suppress the growth of bad breath-causing microorganisms are satisfied, the proliferation of various bad breath-causing microorganisms can be suppressed, thereby exhibiting an excellent bad breath prevention and suppression effect. The neutral pH represented by the reaction of the first agent and the second agent means a pH in the range of 5 to 8 as an intermediate pH between the first agent and the second agent used.

The composition for oral cavity according to the present invention may be prepared in various formulations of oral hygiene enhancers such as toothpaste, mouthwash, mouthwash and the like. Hereinafter, each component of the toothpaste, mouthwash, and mouthwash will be described in detail.

First, when the present invention is formulated oral composition to toothpaste, the toothpaste of the present invention contains the acidic pH adjusting agent and basic pH adjusting agent as essential components, in addition to abrasives, wetting agents, foaming agents, thickeners, preservatives, sweeteners, Fragrances, other additives and the like.

The abrasive may be a colloidal silicon oxide, calcium dihydrogen phosphate, calcium carbonate, aluminum hydroxide, precipitated silica, hydrous silicic acid and the like as a component for removing plaque, tartar, and the like attached to teeth.

The humectant is a component for inhibiting evaporation of water in the toothpaste composition and preventing solidification when the phase is exposed to the air. One or two kinds of polyhydric alcohols such as glycerin, sorbitol liquid, amorphous sorbitol liquid, polyethylene glycol, and propylene glycol are used. The above can be selected and used.

The foaming agent is a component having an emulsification effect of the water-soluble component and the oil-soluble component in the toothpaste composition and the cleaning effect in the oral cavity, such as sodium lauryl sulfate, sodium N-lauroyl salcosylate, N-long chain acyl glutamate, sucrose fatty acid ester, Anionic and nonionic surfactants such as polyoxyethylene hardened castor oil, sorbitan fatty acid ester, and polyoxyethylene polyoxypropylene copolymer can be used alone or in combination of two or more thereof.

The thickener prevents phase separation with time by combining an inorganic powder component and a liquid component which is insoluble in water in the dentifrice composition, and imparts viscosity to the composition, carboxymethylcellulose sodium, carrageenan, xanthan gum, polyvinyl p Ralidone, sodium alginate, other gums and the like can be used.

The preservative may be used as a component for extending the shelf life of the toothpaste composition, paraoxybenzoic acid ester, benzoic acid, sodium benzoate and the like.

The sweeteners and flavorings as a component for improving the taste when refreshing and refreshing the aftertaste after brushing, as a sweetener may be used sodium saccharin, aspartame, stevioside, licoriceic acid, and the like as peppermint, spearmint oil, Menthol, carbon, anetol, eugenol, etc. can be mixed and used.

As other additives, brighteners such as titanium dioxide, and food coloring agents such as blue No. 1 can be used as colorants.

Second, when the oral composition of the present invention is formulated as an oral cleanser, the oral cleanser of the present invention contains the acidic pH adjusting agent and the basic pH adjusting agent as essential components, in addition to the wetting agent, sweetening agent, foaming agent and solubilizer, astringent agent. , Preservatives, colorants, flavors, solvents and the like.

The components of the oral cleaning agent may be the same as each of the components in the toothpaste composition, except that zinc chloride may be used as the astringent, ethanol and purified water may be used as the solvent.

Third, when the oral composition of the present invention is formulated as an oral cleanser, the oral cleanser of the present invention contains the acidic pH adjusting agent and the basic pH adjusting agent as essential components, and in addition to the blowing agent, the moisture remover, the foaming agent, the binder, the lubricant. Agent, fragrance, solvent, and the like.

The blowing agent may be at least one selected from the group consisting of sodium bicarbonate, ammonium bicarbonate, potassium bicarbonate and iron carbonate as a component for oral cleaning.

The dehumidifying agent may be sodium carbonate as a component for formulating the mouthwash into tablets in the form of anhydride.

As the binder, a water-soluble polymer may be used, and carboxyl cellulose or polyvinylpyrrolidone may be preferably used.

The lubricant may be selected from the group consisting of magnesium stearate, stearic acid, stearyl alcohol, sucrose fatty acid ester, talc, light silicic anhydride and sodium benzoate, preferably sodium benzoate.

Hereinafter, the present invention will be described in detail with reference to Examples and Comparative Examples, but the present invention is not limited only to these examples.

<Examples 1-3 and Comparative Examples 1-3> Toothpaste

Toothpaste of Comparative Examples 1 to 3 were accurately quantified and mixed with the following composition and content, and then prepared a toothpaste paste by a general method of manufacturing a toothpaste was filled in a general toothpaste container.

Toothpaste of Examples 1 to 3 were accurately quantified and mixed with the composition and content of the following first and second formulations, respectively, and then toothpaste pastes were prepared by the general toothpaste manufacturing method. Next, the first paste and the second paste were filled in a toothpaste container with a diaphragm. On the other hand, the pH of the first paste and the second paste of each of the examples was measured using a pH meter and shown below.

Ingredient (% by weight) Comparative example Example 1 Example 2 Example 3 One 2 3 First paste 2nd paste First face 2nd paste First paste 2nd paste Colloidal Silicon Oxide 6.00 6.00 6.00 6.00 6.0 6.00 6.0 6.00 6.0 glycerin 20.00 20.00 20.00 20.00 20.0 20.00 20.0 20.00 20.0 Hydrous silicon dioxide 16.50 16.50 16.50 16.50 16.50 16.50 16.50 16.50 16.50 Xanthan Gum 0.30 0.30 0.30 0.30 0.3 0.30 0.3 0.30 0.3 Paraoxybenzoic Acid Methyl 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Saccharin Sodium 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 Blue No. 1 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 Titanium dioxide 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Sodium Lauryl Sulfate 3.50 3.50 3.50 3.50 3.5 3.50 3.5 3.50 3.5 Combination Spices (Mint Flavor B70097) 2.00 2.00 2.0 2.00 2.00 2.00 2.00 2.00 2.00 Citric acid - 0.8 - 0.8 - 0.35 - 0.2 - Potassium Hydroxide (10% Solution) - - 0.5 - 0.5 - - - - Sodium hydroxide - - - - - - 0.64 - - Sodium Phosphate (Na ₃ PO ₄ ) - - - - - - - - 0.5 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 pH 7.3 4.3 8.5 4.3 8.5 5.07 8.3 5.67 8.48

Test Example 1 pH Measurement

In the toothpaste of Examples 1 to 3, each of the first paste and the second paste by mixing in a ratio of about 1: 1 to react them and then measure the pH using a pH meter and The results are shown in Table 1 below.

Example 1 Example 2 Example 3 First paste 2nd paste First paste 2nd paste First paste 2nd paste PH before reaction 4.3 8.5 5.07 8.3 5.67 8.48 PH after the reaction of the first paste and the second paste 5.4 6.27 7.7

When the toothpaste of the present invention is applied to the oral cavity from Table 1, various pH ranges exist in the oral cavity, and thus, all of the effective pH ranges required for suppression of proliferation of bad breath-causing microorganisms can be satisfied. It is thought that the growth can be suppressed.

<Test Example 2> antibacterial activity test

1 g of the toothpaste of Examples 1 to 3 and Comparative Example 1 was diluted and suspended in 19 g of sterile phosphate buffer and used in the following experiment.

That is, 2 ml of diluted test solution and 18 ml of blood agar medium (blood agar base + final blood 5% sheep) were poured into a 9 cm petri dish. The test bacteria were then inoculated and incubated at 37 ° C. for 96 hours using an anaerobic chamber. The maximum dilution rate at which the test bacteria did not grow was measured by MID, and the results are shown in Table 2 (Bactron I. anaerobic chamber was used).

The test bacteria were Fusobacterium nucleatum ATCC 25586 and Porphyromonas gingivalis ATCC 33277.

Test bacteria Comparative Example 1 Comparative Example 2 Comparative Example 3  Example 1  Example 2 Example 3 Fusobacterium nucleatum 320 1,800 1,600 2,560 2,400 2,100 Porphyromonas gingivalis 120 1,900 1,500 2,560 2,350 2,150

When using the toothpaste of the present invention from Table 2, the acid, basic and neutral pH is present in the oral cavity, the general toothpaste of Comparative Example 1 showing neutrality, the toothpaste of Comparative Example 2 showing acidity and basic comparison It was found that the antibacterial activity against the causative bacteria causing bad breath was superior to the toothpaste of Example 3.

<Test Example 3> Bad breath measurement

Each of the patients in need of bad breath management was selected from 40 patients, and the toothpastes of Comparative Examples 1 to 3 and Examples 1 to 3 prepared above were used twice a day for 1 week, followed by a halimeter (interscan Co. chartworth. CA. USA) was used to measure the presence or absence of bad breath by the following method, and the result was determined according to the following evaluation method and the results are shown in Table 3. For reference, the Halimeter is a device that can measure the concentration of volatile sulfur compounds in parts per billion (ppb).

(1-1) Measuring method

① Turn on the power for at least 30 minutes before starting the measurement.

② Adjust the zero point so that the value of the limiter is between 10ppb.

③ Shut your mouth to collect volatile sulfur compounds in your mouth for 3 minutes before measurement.

④ Insert the disposable tube connected to the Halimeter so that it does not touch the mucosa of the first molar in the oral cavity of the investigator, and keep the mouth closed for about 1 minute (to prevent blowing wind or inhaling saliva and breathing) Tolerate or breathe through your nose).

⑤ Remove the tube after recording if it shows the highest halitometer measurement result.

⑥ Wait until the reading is between 10 ppb again for the next measurement.

⑦ Repeat the above process to measure the bad breath three times to find the average value and record it. (1-2) Reading and Evaluation Criteria

Can't feel obvious bad breath: 50ppb ~ 80ppb

Bad breath: 80ppb ~ 150ppb or more

Bad breath need: 150ppb ~ 200ppb

Degree of definite treatment required: more than 200 ppb

Changes in Mean Sulfur Compounds Concentration with Treatment Before use after use Comparative Example 1 Group 1 (20) 140 ± 5.4 142 ± 7.0 Group 2 (20 people) 221 ± 11.2 214 ± 12.7 Comparative Example 2 Group 1 (20) 141 ± 9.5 135 ± 7.2 Group 2 (20 people) 225 ± 10.5 215 ± 9.2 Comparative Example 3 Group 1 (20) 140 ± 6.5 137 ± 8.0 Group 2 (20 people) 240 ± 11.6 235 ± 9.0 Example 1 Group 1 (20) 145 ± 7.2 72 ± 3.2 Group 2 (20 people) 272 ± 10.4 148 ± 5.4 Example 2 Group 1 (20) 143 ± 10 102 ± 5.2 Group 2 (20 people) 232 ± 12.0 180 ± 7.2 Example 3 Group 1 (20) 142 ± 11.4 120 ± 4.8 Group 2 (20 people) 252 ± 7.4 203 ± 6.3

Table 3 shows that the use of the toothpaste of the present invention showed a significant effect of reducing bad breath compared to the case of using the general toothpaste of Comparative Example 1, the acidic toothpaste of Comparative Example 2, and the basic toothpaste of Comparative Example 3. Could.

Experimental Example 4 Measurement of Tooth Discoloration

After the toothpaste of Examples 1 to 3 of the present invention is used for a healthy person in their 20s to 30s for one week, the tooth sample is extracted, and the extracted tooth sample is fixed to the epoxy resin so that the exposed area is horizontal × vertical ( After the specimen was prepared to be 2mm × 2mm), the whiteness was measured using a color difference meter (Model: SZ, Nippon Denshoku). On the other hand, the whiteness change rate of the tooth when the toothpaste of the present invention using the whiteness of the tooth sample before using the toothpaste is shown in Table 4 below.

 Example 1  Example 2 Example 3 % Change in whiteness 0 0 0

Table 4 shows that even when the toothpaste of the present invention is used, side effects such as tooth discoloration do not occur.

<Example 4 and Comparative Examples 4 to 6> mouthwash

The oral cleanser of Example 4 accurately quantifies and mixes the components with the composition and content of the following first and second agents, prepares the respective oral cleansers by a general method of preparing oral cleansers, and then The second mouthwash was filled in a separate container and used in a ratio of about 1: 1 immediately before the following experiment.

The mouthwashes of Comparative Examples 4 to 6 were accurately quantified and mixed with the following compositions and contents, and then prepared with mouthwashes by a general method of preparing mouthwashes, and filled in the general mouthwash container.

The pH was measured for each mouthwash and shown below.

Ingredients (mg / 100ml) Example 4 Comparative example First agent Second agent 4 5 6 Sodium fluoride 20 20 20 20 20 ethanol 6.6 6.6 6.6 6.6 6.6 glycerin 6 6 6 6 6 Polyoxyl 40 hydrogenated castor oil 30 30 30 30 30 Sodium Lauryl Sulfate 100 100 100 100 100 Sodium citrate 100 100 100 100 100 Saccharin Sodium 20 20 20 20 20 Methyl paraoxybenzoate 34 34 34 34 34 Paraoxybenzoic acid propyl 17 17 17 17 17 Zinc chloride 10 10 10 10 10 Toothpaspe flover AQF 188 Quantity Quantity Quantity Quantity Quantity Window color 1 Quantity Quantity Quantity Quantity Quantity Citric acid 0.35 - - 0.35 - Sodium hydroxide - 0.64 - - 0.64 Purified water Quantity Quantity Quantity Quantity Quantity pH 5.07 8.48 7.5 5.07 8.3

Test Example 5 pH Measurement

The first mouthwash and the second mouthwash of Example 4 filled in each separate container are mixed and mixed in a ratio of about 1: 1, and then completely reacted, and then the pH is adjusted using a pH meter. Measured.

As a result, the pH was found to be 6.4. Therefore, even when the oral detergent of the present invention is applied to the oral cavity, various pH ranges exist in the oral cavity, and thus, all of the effective pH ranges required for suppression of proliferation of bad breath-causing microorganisms can be satisfied. It is thought that the growth can be suppressed.

Test Example 6 Antibacterial Activity Test

The antimicrobial activity was measured in the same manner as in Test Example 2, except that the test solution diluted in the ratio of 1:20 using the purified water using the oral cleanser of Example 4 and Comparative Examples 4 to 6 was measured. Table 5 shows.

Test bacteria Example 4 Comparative Example 4 Comparative Example 5  Comparative Example 6 Fusobacterium nucleatum 2,300 300 1,500 1,700 Porphyromonas gingivalis 2,280 130 1,550 1,700

When the oral cleanser of the present invention is used in Table 5, acidic, basic and neutral pH are present in the oral cavity, and the general oral cleanser of Comparative Example 4 showing neutrality and the oral cleanser and basic of Comparative Example 5 showing weak acidity It was found that the antimicrobial activity against the causative bacteria causing bad breath was excellent as compared to the mouthwashes of Comparative Example 6 showing.

<Test Example 7> Bad breath measurement

The molar was measured in the same manner as in Test Example 3 except that the mouthwashes of Example 4 and Comparative Examples 4 to 6 were used, and the results are shown in Table 6.

Changes in Mean Sulfur Compounds Concentration with Treatment Before use after use Example 4 Group 1 (20)   140 ± 10.5 105 ± 4.8 Group 2 (20 people)   235 ± 11.0 195 ± 8.5 Comparative Example 4 Group 1 (20)  141 ± 6.7 139 ± 5.4 Group 2 (20 people)   220 ± 10.5  217 ± 11.5 Comparative Example 5 Group 1 (20)  142 ± 7.5 138 ± 6.3 Group 2 (20 people)   235 ± 12.0 227 ± 9.0 Comparative Example 6 Group 1 (20)  145 ± 8.0 141 ± 5.4 Group 2 (20 people)   240 ± 10.0 236 ± 9.0

In the case of using the mouthwash of the present invention from Table 6, compared to the case of using the general mouthwash of Comparative Example 4, the weakly acidic mouthwash of Comparative Example 5, the basic mouthwash of Comparative Example 6, the effect of remarkable reduction of bad breath It could be seen that.

Test Example 8 Measurement of Tooth Discoloration

As a result of measuring the change rate of discoloration of the tooth in the same manner as in Test Example 4, except that the mouthwash of Example 4 of the present invention was used, no side effects such as tooth discoloration were induced even when the mouthwash of the present invention was used. I could see.

<Example 5 and Comparative Examples 7 to 9> Tablet type mouthwash

The tablet-type mouthwash of Example 5 was precisely quantitatively mixed with each component by the composition and content of the following first and second agents, and then tablets were made to be 1.0 ± 0.1 g using a tableting machine. After diluting the first tablet and the second tablet with 10 ml of water, 5 ml of the first tablet and the second tablet were respectively used immediately in the experiment.

Tablet mouthwashes of Comparative Examples 7 to 8 were also prepared in the same manner as in Example 5. The tablets were then diluted in 10 ml of water and used for the following experiment. The pH of each purified liquid was measured and shown below.

Ingredient (% by weight) Example 5 Comparative example First agent Second agent 7 8 9 Sodium fluoride 20.0 20.0 20.0 20.0 20.0 glycerin  2.0  2.0  2.0  2.0  2.0 Hydrogen carbonate fume 40.0 40.0 40.0 40.0 40.0 Sodium carbonate 10.0 10.0 10.0 10.0 10.0 Sodium Lauryl Sulfate  3.0  3.0  3.0  3.0  3.0 Polyvinylpyrrolidone  3.0  3.0  3.0  3.0  3.0 Saccharin Sodium  1.0  1.0  1.0  1.0  1.0 incense  7.0  7.0  7.0  7.0  7.0 Citric acid  0.2 - -  0.2 - Sodium phosphate -  0.5 - -  0.5 pH 5.67 8.48 7.79 5.67 8.48

Test Example 9 pH Measurement

The first mouthwash and the second mouthwash of Example 5 diluted in each separate container are reacted by combining and mixing in a ratio of about 1: 1, and then pH is measured using a pH meter. It was.

As a result, pH was 7.8. Therefore, even when the oral cleaner of the present invention is applied to the oral cavity, various pH ranges exist in the oral cavity, thereby satisfying all effective pH ranges required for suppression of proliferation of bad breath-causing microorganisms. It is thought that the growth can be suppressed.

Test Example 10 Antibacterial Activity Test

The antibacterial activity was measured in the same manner as in Test Example 2, except that the test solution in which the mouthwash solutions of Examples 5 and Comparative Examples 7 to 9 were diluted again with a ratio of 1:20 using purified water was used. Is shown in Table 7.

Test bacteria Example 5 Comparative Example 7 Comparative Example 8  Comparative Example 9 Fusobacterium nucleatum 2,150 290 1,450 1,550 Porphyromonas gingivalis 2,200 125 1,400 1,500

When the oral cleanser of the present invention is used from Table 7, the acidic, basic and neutral pHs are present in the oral cavity, and the general oral cleanser of Comparative Example 7 showing neutrality, the oral cleanser of Comparative Example 8 showing weak acidity, and It was found that the antibacterial activity against the causative bacteria causing bad breath was excellent compared to the mouthwash of Comparative Example 9 showing basicity.

Test Example 11 Bad Breath Measurement

Except for using the mouthwashes of Example 5 and Comparative Examples 7 to 9, the molar was measured in the same manner as in Test Example 3, and the results are shown in Table 8.

Changes in Mean Sulfur Compounds Concentration with Treatment Before use after use Example 5 Group 1 (20)  143 ± 10.5 123 ± 5.4 Group 2 (20 people) 250 ± 8.2 209 ± 7.0 Comparative Example 7 Group 1 (20) 142 ± 9.7 139 ± 10.0 Group 2 (20 people) 242 ± 8.0 240 ± 7.5 Comparative Example 8 Group 1 (20) 141 ± 10.0 138 ± 5.1 Group 2 (20 people) 240 ± 9.0 235 + 7.5 Comparative Example 9 Group 1 (20) 145 ± 11.2 142 ± 9.0 Group 2 (20 people) 240 ± 8.5 235 + 6.5

In the case of using the mouthwash of the present invention from Table 8, the significant reduction in bad breath compared to the case of using the general mouthwash of Comparative Example 7, the weakly acidic mouthwash of Comparative Example 8, the basic mouthwash of Comparative Example 9 It could be seen that.

Test Example 12 Measurement of Tooth Discoloration

Except that the mouthwash of Example 5 is used, the rate of change of tooth discoloration was measured in the same manner as in Test Example 4, and it was found that no side effects such as tooth discoloration were induced even when the mouthwash of the present invention was used. Could.

As described above, the oral composition according to the present invention can suppress the proliferation of various bad breath-causing microorganisms in the oral cavity simply by adjusting the pH using a pH adjuster used in a conventional oral composition, thereby providing excellent bad breath by a simple method. Prophylactic and inhibitory effects can be provided.

In addition, the microorganisms causing bad breath are associated with not only bad breath but also periodontal disease, tooth decay, etc. When using the oral composition of the present invention, in addition to the bad breath prevention and suppression effect, it can additionally prevent periodontal disease, tooth decay.

In addition, the pH adjusting agents used in the present invention do not cause side effects such as tooth discoloration because they are components that have already been proven to be safe as components that have been conventionally used in oral compositions.

Claims (11)

delete delete delete delete A first agent comprising an acidic pH adjuster using any one or more of the group consisting of citric acid, tartaric acid, boric acid, phosphoric acid, or hydrochloric acid; A second agent comprising a basic pH adjuster using any one or more of the group consisting of sodium, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium pyrophosphate, potassium pyrophosphate or ethylenediaminetetraacetate disodium (EDTA 2Na). , Bad breath characterized in that the first agent and the second agent is blended in a ratio of 1: 1, the first agent is adjusted to pH 4 to 6.5, the second agent is adjusted to pH 7.5 to 10 Oral composition for inhibition. The composition for inhibiting bad breath according to claim 5, wherein the first agent and the second agent are paste-like. The oral composition for inhibiting bad breath, according to claim 6, wherein the first agent and the second agent are filled in a double container having a diaphragm or in a separate container. delete The oral composition for inhibiting bad breath according to claim 5, wherein the acidic, basic and neutral pHs are all expressed in the oral cavity by using the first agent and the second agent in a ratio of 1: 1. delete The oral composition for inhibiting bad breath, according to claim 5, wherein the oral composition is formulated as a toothpaste, mouthwash or mouthwash.