KR100825279B1 - Ｄｎα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자 - Google Patents

Ｄｎα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자 Download PDF

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Publication number: KR100825279B1
Authority: KR; South Korea
Prior art keywords: protein; seq; dna; dna polymerase; nucleic acid
Prior art date: 2006-11-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

KR1020060119613A

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English (en)

Korean (ko)

Inventor

이정현

강성균

김상진

권개경

이현숙

김윤재

유용구

배승섭

임재규

전정호

조요나

정인순

권석태

Original Assignee

한국해양연구원

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-30

Filing date

2006-11-30

Publication date

2008-04-25

2006-11-30 Application filed by 한국해양연구원 filed Critical 한국해양연구원

2006-11-30 Priority to KR1020060119613A priority Critical patent/KR100825279B1/ko

2007-11-30 Priority to PCT/KR2007/006150 priority patent/WO2008066350A1/fr

2008-04-25 Application granted granted Critical

2008-04-25 Publication of KR100825279B1 publication Critical patent/KR100825279B1/ko

Status Active legal-status Critical Current

2026-11-30 Anticipated expiration legal-status Critical

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
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Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

KR1020060119613A 2006-11-30 2006-11-30 Ｄｎα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자 Active KR100825279B1 (ko)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
KR1020060119613A KR100825279B1 (ko)	2006-11-30	2006-11-30	Ｄｎα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자
PCT/KR2007/006150 WO2008066350A1 (fr)	2006-11-30	2007-11-30	Ditpase et gènes le codant

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Application Number	Priority Date	Filing Date	Title
KR1020060119613A KR100825279B1 (ko)	2006-11-30	2006-11-30	Ｄｎα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자

Publications (1)

Publication Number	Publication Date
KR100825279B1 true KR100825279B1 (ko)	2008-04-25

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KR (1)	KR100825279B1 (fr)
WO (1)	WO2008066350A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101142950B1 (ko)	2008-12-05	2012-05-08	성균관대학교산학협력단	써모코커스 마리너스 균주 유래의 내열성 ｄｎａ 중합효소 및 이의 이용

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR970010965A (ko) *	1995-08-25	1997-03-27	클라우스너 프리돌린, 보러 롤란드	핵산 증폭 방법
KR20070039418A (ko) *	2005-10-08	2007-04-12	한국해양연구원	고호열성 ｄｎａ 중합효소 및 이의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3112148B2 (ja) *	1995-05-31	2000-11-27	東洋紡績株式会社	核酸の増幅方法およびその試薬
EP1456394B2 (fr) *	2001-11-28	2011-04-27	Bio-Rad Laboratories, Inc.	Procedes d'utilisation de polymerases ameliorees

2006
- 2006-11-30 KR KR1020060119613A patent/KR100825279B1/ko active Active
2007
- 2007-11-30 WO PCT/KR2007/006150 patent/WO2008066350A1/fr active Application Filing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR970010965A (ko) *	1995-08-25	1997-03-27	클라우스너 프리돌린, 보러 롤란드	핵산 증폭 방법
KR20070039418A (ko) *	2005-10-08	2007-04-12	한국해양연구원	고호열성 ｄｎａ 중합효소 및 이의 제조방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101142950B1 (ko)	2008-12-05	2012-05-08	성균관대학교산학협력단	써모코커스 마리너스 균주 유래의 내열성 ｄｎａ 중합효소 및 이의 이용

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Publication number	Publication date
WO2008066350A1 (fr)	2008-06-05

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KR100825279B1 - Ｄｎα 중합효소 활성 증가 단백질 및 이를 암호화 하는유전자 - Google Patents

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