KR100879094B1 - Cosmetic composition for acne improvement containing a natural essential oil component and its hydrosol component - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving acne comprising a natural essential oil component including lavender essential oil and tea tree essential oil and a lavender hydrosol and tea tree hydrosol components obtained at the time of extracting the essential oil, wherein the cosmetic composition is a natural lavender essential oil. By simultaneously containing the four components of tea tree essential oil, lavender hydrosol and tea tree hydrosol, the cosmetic composition is excellent in inhibiting the growth of acne bacteria, acne skin improvement cosmetics for providing acne prevention and relief effect It relates to a composition.

Lavender, Tea Tree, Hydrosol, Acne, Cosmetics

Description

Cosmetic composition for acne improvement containing a natural essential oil component and its hydrosol component {COSMETICS FORMULATION CONTAINING NATURAL ESSENTIAL OILS AND ITS HYDROSOLS}

The present invention relates to a cosmetic composition for improving acne containing a natural essential oil component including a lavender essential oil and a tea tree essential oil, and a natural aromatic water, a lavender hydrosol and a tea tree hydrosol component. More specifically, natural antibacterial essential oil having excellent anti-proliferative ability of acne causing bacterium Propionibacterium acnes and inhibitory activity of 5α-reductase involved in sebum oversecretion of acne patients and obtained during the extraction of the essential oil It relates to a cosmetic composition having an acne prevention and alleviating effect containing a hydrosol component.

Acne is known to be caused by a combination of various causes. In general, acne has increased secretion of sebaceous glands due to increased male hormone function in puberty, and epithelial cells of hair follicles cause abnormal keratosis and blockage of hair follicles. It is recognized that the propensium bacterium Propionibacterium acne actively proliferates to produce free fatty acid, which stimulates hair follicles and causes acne inflammation. This progression to acne is exacerbated by sebum oversecretion associated with 5α-reductase.

Conventionally, as a method for treating or alleviating acne, a method using a female hormone such as estrogen, a male hormone inhibitor, or an antibacterial agent has been used to suppress sebum hypersecretion. In recent years, a method of inhibiting sebum hypersecretion by using a 5α-reductase inhibitor has been proposed.

However, the method of using female hormones is a side effect during the treatment of acne, in addition to the high risk of skin irritation as a side effect, there have been many reports of side effects caused by long-term administration of female hormones are not used very much, Even if it is used, only a small amount is prescribed carefully under the observation of a doctor.

Currently used acne treatments use topical therapy, which is a method of cleansing the skin, peeling off the stratum corneum, opening the hair follicles to facilitate sebum secretion, and using triclosan or hexaclorophen to treat acne. It is a method of sterilization. However, care should be taken that it can cause contact dermatitis. In addition, retinoic acid is a vitamin derivative that inhibits the formation of microsurface vesicles and is an agent that acts to reduce the number of vesicles formed. This is important for reducing the adhesion of keratinocytes in the hair follicles, so it is effective in treating acne with the addition of scleral disease. High concentrations cause irritation such as erythema and sulphate, so use a cream or gel form of 0.01 ~ 0.05.

Benzoyl peroxide reduces P. acne (propion bacterium acne) and is mainly effective for inflammatory acne. The titration is used in the form of gel of 2-5, but irritating and itchy and hot. Sulfur has an effect on the keratolytic effect and the sebum removal effect. It can be used for 2 to 10 years, but it is not suitable for cosmetics due to discoloration or odor of the skin. One of the most widely used raw materials for cosmetics is salicylic acid, which acts on the exfoliation effect and is used for about 0.5 to 2.0, but the skin irritation is severe and the content is decreasing. As an antibiotic for topical application, clindamycin external ointment is most effective, and erythromycin, tetracycline, sulfonamide, etc. are used, but all are used as a pharmaceutical agent and are not registered in the enteric device.

In addition, by using a moisturizer and alpha-hydroxy acid (AHA) that can soften keratin, it can help to heal acne by promoting the release of sebum, but it can dissolve the skin more than necessary and leave a wound. In particular, it may cause problems such as skin irritation.
Therefore, the inventors of the present invention to solve the problems as described above, the main ingredient is a natural essential oil component with excellent acne antibacterial properties and a natural hydrosol containing a large number of water-soluble active ingredients when extracting essential oils, antibacterial effect and 5α- As a result of measuring the activity inhibitory effect of reductase, the lavender and tea tree natural essential oil components and the hydrosol component obtained at the essential oil extraction found excellent effects in both of these aspects, and came to complete the present invention.

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It is an object of the present invention to provide a cosmetic composition for improving acne comprising a natural plant extract component, comprising tea tree and lavender natural essential oil components and tea tree and lavender hydrosol components obtained at the time of extracting the essential oil. .

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Acne improvement cosmetic composition according to the present invention for achieving the above object is a natural essential oil component having excellent antimicrobial activity and excellent 5α-reductase activity inhibitory activity against acne bacteria as a main component Since it contains, it shows excellent acne prevention and alleviating effectiveness, suggests a useful application as a cosmetic composition for improving acne.
Hereinafter, the present invention will be described in more detail.

The cosmetic composition for improving acne according to the present invention simultaneously contains a natural essential oil component including a lavender essential oil and a tea tree essential oil and a hydrosol component of natural floral water. Ingredients of the cosmetic composition for improving acne of the present invention is a natural essential oil component including lavender essential oil and tea tree essential oil in the whole composition, and natural floral water including lavender hydrosol and tea tree hydrosol obtained when the essential oil is extracted. ) And a hydrosol component.

Lavander's Botanical Name is Lavandula officinalis , which is a herb and balsam odor, colorless to slightly yellow liquid, and lavender flowers are extracted by steam distillation. Get Its main components include d-bprneol, cineol, carophyllene, coumarin, geraniol, ester, l-pinene, linalyl, butyric acid and valerianic acid, which are effective for acne and oily skin by controlling sebum secretion. In addition, it helps to alleviate sunburn, and has an excellent skin soothing and regenerating effect. Lavender component contains 0.1 to 5% by weight of the components of the cosmetic composition of the present invention, less than 0.1% by weight is insufficient acne relieving effect, 5% by weight or more content is too strong fragrance and skin rejection when applied Can give

Tea Tree's Botanical Name is Melaleuca alternifolia , which is a strong fragrance that gives a cool, clean and clean feel, is a thin, pale yellow liquid, and the tea tree leaves are extracted by steam distillation. Get by Its main ingredients include Terpinen-4-ol, g-terpinene, 1,8-cineol, etc. Tea tree essential oils are versatile for astringent, cleansing and cleansing. Antibacterial and bactericidal effect is effective for acne improvement and prevention. Tea tree component contains 0.1 to 5% by weight of the components of the cosmetic composition of the present invention, less than 0.1% by weight is insufficient acne relieving effect, 5% or more by weight is too high fragrance when applied to the skin It can be rejective, and it can sometimes irritate your skin.

Generally, the method of extracting the aromatic natural essential oil is steam distillation, and the method of extracting the aromatic natural essential oil by breaking the cell wall of the plant using hot water or steam. That is, when the cell wall of the plant is broken above a predetermined temperature, the fragrance substance is evaporated, and when the evaporated fragrance substance is cooled again, a liquid essential oil can be obtained. At this time, the water evaporated together will be dissolved in the water-soluble active ingredients of the natural plant components, such extraction water (water) is called floral water (floral water) or hydrosol (Hydrosol). In particular, the hydrosol contains a large amount of water-soluble components soluble in water among the plant extract obtained through steam distillation, the components insoluble in water will float on the water with aroma oil after extraction. Thus, this natural hydrosol contains various water soluble plant active ingredients that are not contained in natural essential oils.

Therefore, the use of lavender hydrosol and tea tree hydrosol together with lavender and tea tree essential oils gives synergistic effect of applying the water-soluble ingredients contained in the original lavender and tea tree plants that are not in the essential oils.

Lavender Hydrosol is very effective for oily and acne skin, irritated skin, and it helps to control skin pH, soothing, converging and cleansing, especially for soothing and cleansing damaged skin. Lavender hydrosol may contain from 5 to 95% by weight of the components of the cosmetic composition of the present invention, more preferably from 5 to 15% by weight. At this time, less than 5% by weight of the acne relieving effect is insignificant, in the case of 95% by weight or more, the content in the total composition is too high, the synergistic side with other components is reduced.

Tea Tree Hydrosol is very effective for oily and acne skin, irritated skin, and helps to soothe, convergence and cleanse of skin irritation and inflammation. Especially, it has excellent antibacterial effect. Tea tree hydrosol may contain 5 to 95% by weight of the components of the cosmetic composition of the present invention, preferably 5 to 15% by weight. At this time, less than 5% by weight of the acne relieving effect is insignificant, in the case of 95% by weight or more, the content in the total composition is too high, the synergistic side with other components is reduced.

The cosmetic composition for acne improvement of the present invention comprising the lavender, tea tree essential oil and natural floral water lavender, tea tree hydrosol (Hydrosol) extract, excellent antibacterial activity and excellent 5α- against acne bacteria Cosmetic ingredients generally used in external preparations for skin, such as aqueous components, powder components, oils, surfactants, humectants, thickeners, preservatives, and oxidation, within the range that does not inhibit the expression of reductase activity inhibitory activity, etc. It can be combined with anti-perspirant, fragrance, pigment, etc., and it is known and used as various cosmetic formulations such as skin lotion, flexible lotion, astringent lotion, cream, lotion, latex foundation, face wash such as pack, face wash foam, functional soap, etc. It can of course be formulated according to the method.

As described above, the functional cosmetic composition for preventing and alleviating acne, which is formulated according to the present invention, can be used alone, but it can be used as a conventional acne treatment agent if necessary within the range that does not lower the effect of the functional cosmetic composition of the present invention. Combination with various types of antibacterial agents such as benzoyl peroxide, tetracycline, or erythromycin, anti-androgens, hormones such as steroids, vitamin A derivatives such as retinoic acid, or the above antibacterial agents or physiology It can also be used in combination with cocktail therapy in combination with an active agent, which is expected to be synergistic.

Cosmetic composition of the present invention is characterized in that it contains four components of lavender essential oil, tea tree essential oil, lavender hydrosol, tea tree hydrosol at the same time, the application in the form of applying the following two different products to the skin together Also includes. That is, one cosmetic composition is made of a product characterized in that it contains two components of lavender essential oil, tea tree essential oil at the same time and does not contain lavender hydrosol, tea tree hydrosol, the remaining cosmetic composition is lavender hydrosol, tea It is manufactured by simultaneously containing two components of trihydrosol and not containing lavender essential oil and tea tree essential oil, and applying the two products together to the skin and ultimately applying the four components to the skin. It includes utilization of furnace.

Hereinafter, the present invention will be described in detail by way of examples.
The following examples are merely illustrative of the present invention, but the scope of the present invention is not limited to the following examples.

<Examples 1-3 and Comparative Examples 1-3>

According to the composition of Table 1 below, a typical skin lotion acne improvement cosmetic composition containing four components of lavender, tea tree essential oil and lavender, tea tree hydrosol at the same time as Example 1-3, lavender, tea tree essential oil And a skin lotion cosmetic composition of Comparative Example 1-3 was prepared according to a conventional method with respect to the cosmetic composition containing or not containing only a part of four components of lavender and tea tree hydrosol.

ingredient Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 glycerin 5.0 5.0 5.0 5.0 5.0 5.0 1,3-butylene glycol 3.0 3.0 3.0 3.0 3.0 3.0 ethanol 5.0 5.0 5.0 5.0 5.0 5.0 Polyoxyethylene nonylphenyl ether 0.4 0.4 0.4 0.4 0.4 0.4 Lavender / Tea Tree Essential Oil 1.0 / 1.0 1.0 / 1.0 1.0 / 1.0 - - 1.0 / 1.0 Lavender / Tea Tree Hydrosol 10/10 15/5 5/15 - 10/10 - Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount system 100 100 100 100 100 100

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Experimental Example 1 Acne Antibacterial Test

The antimicrobial effect of Example 1-3 and Comparative Example 1-3 was measured as follows.

After incubating each strain for 1 day, 200 µl was plated in a petri dish, 1 g of each extract was dissolved in 2 ml of 50% 1, 3-butylene glycol aqueous solution, and 30 µl of the mixed solution was taken. Each acne bacterium was inoculated onto a paper disc (點 適) and cultured under the following conditions (Table 2).

Culture conditions of strains for measuring the antimicrobial effect of natural extracts according to the present invention Strains Medium Time, temperature type Acne Bacteria (Propionibacterium acne ATCC 6919) Reinforced clostridial agar medium 72 hours, 37 ℃ anaerobe

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The results are shown in Table 3 to measure the diameter of the clear zone appearing around the paper disc (paper disc).
Experimental Results for Examples and Comparative Examples (Clean Area Diameter Unit: mm) sample Clean area Example 1 21 Example 2 19 Example 3 18 Comparative Example 1 0 Comparative Example 2 3 Comparative Example 3 11

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As a result of the acne antibacterial test, Example 1-3, a skin lotion cosmetic composition containing four components of lavender, tea tree essential oil, lavender, and tea tree hydrosol simultaneously, contains only a single component among four components, or , Showed better antimicrobial activity than Comparative Examples 1-3 containing no four components at all.

Experimental Example 2 5α-Reductase Inhibitory Activity

Lavender, tea tree essential oil and lavender, tea tree hydrosol four components of the common skin lotion acne improvement cosmetic composition Examples 1-3 and lavender, tea tree essential oil and lavender, tea tree hydrosol four components In Comparative Example 1-3, which is a skin lotion cosmetic composition containing or not containing only some components, 5α-reductase inhibitory activity was measured by the following method.

First, partially purified 5α-reductase derived from liver (adult, Sprague-Dawley, male rats) of 8-9 week old rats was extracted. Subsequently, a predetermined amount of protein suspension was prepared by protein quantification, and an enzyme reaction solution was prepared by a general method. Using the radiolabeled testosterone (3H-testosterone) as a reaction substrate of 5α-reductase, the reaction solvent was evaporated and then removed in an incubator for 2 minutes at a ratio of enzyme reaction solution: protein suspension: cosmetic composition = 7: 2: 1. The residue was then dissolved in developing solvent and thin layer chromatography, and the amount of testosterone developed and the amount of dihydrotestosterone were quantitatively analyzed using a densitometer. The conversion rate of testosterone to dihydrotestosterone by 5α-reductase was calculated and the result was compared with the conversion rate when no control group (eyewood leaf perfume oil extract) was added. It evaluated as inhibitory activity (inhibition rate).

The inhibition rate evaluation method is as follows.

% Inhibition = 100 (A-B / A)

In the inhibition rate, A is the conversion rate of testosterone to dihydrotestosterone when no cosmetic composition is added, and B is the conversion rate of testosterone to dihydrotestosterone when the cosmetic composition is added.

Inhibition rate results are shown in Table 4 below.

sample Suppression rate Example 1 100 Example 2 100 Example 3 100 Comparative Example 1 10.2 Comparative Example 2 32.1 Comparative Example 3 57.7

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As a result of the acne antibacterial test, Example 1-3, a skin lotion cosmetic composition containing four components of lavender, tea tree essential oil, lavender, and tea tree hydrosol simultaneously, contains only a single component among four components, or It can be seen that 5α-reductase inhibitory activity is superior to Comparative Examples 1-3 containing no four components at all.

Experimental Example 3 Measurement of Improvement of Acne

In order to confirm the effect of the acne treatment of the present invention, 180 men and women aged 18 to 35 years old divided into two groups of 60 persons each, and 180 persons in one category in the same manner as the daily skin lotion use for three weeks. The skin lotion of 180 persons in another category was allowed to use the skin lotion of Comparative Examples 1-3, and the degree of improvement was determined according to the opinion of the user.

Sebum secretion control effect (unit: number of people) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Very effective 18 21 16 0 One 2 It works 36 31 38 2 4 8 is average 5 5 4 7 14 19 It does not work 0 2 One 19 21 24 No effect at all One One One 32 20 7

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Acne improvement effect (unit: number of people) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Very effective 21 22 19 0 2 4 It works 31 32 32 2 5 10 is average 5 5 5 5 15 19 It does not work 2 One 3 24 21 22 No effect at all One 0 One 29 17 5

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As a result of the experiment, in the case of Example 1-3, which is a skin lotion cosmetic composition containing four components of lavender, tea tree essential oil, lavender, and tea tree hydrosol at the same time, among the four components, it contains only single components, or four kinds: Sebum control properties and acne improvement properties showed better results than Comparative Examples 1-3 containing no components of.

As described above, the cosmetic composition for acne improvement according to the present invention containing the four components of lavender, tea tree essential oil and lavender, tea tree hydrosol at the same time exhibits an excellent growth inhibitory ability against propionibacterium acne, which is the cause of acne. In addition, it showed excellent inhibitory activity against 5α-reductase related to sebum hypersecretion, and showed excellent properties in sebum control ability and acne improving effect, suggesting the use as a cosmetic composition very useful for treating, preventing and / or alleviating acne. .
Although the present invention has been described in detail only with respect to the embodiments described, it will be apparent to those skilled in the art that various modifications and variations are possible within the technical spirit of the present invention, and such modifications and variations belong to the appended claims. .

Claims (3)

A cosmetic composition for improving acne, comprising a natural essential oil component including lavender essential oil and tea tree essential oil and lavender hydrosol and tea tree hydrosol components obtained when the essential oil is extracted, the lavender essential oil 0.1 to 5% by weight, tea A cosmetic composition for improving acne, comprising 0.1 to 5% by weight of a tree essential oil, 5 to 15% by weight of lavender hydrosol, and 5 to 15% by weight of tea tree hydrosol. delete A cosmetic composition for improving acne, comprising a natural essential oil component including a lavender essential oil and a tea tree essential oil, but a cosmetic composition for improving acne of an essential oil component which does not contain lavender hydrosol and tea tree hydrosol obtained at the time of extracting the essential oil. ; And In the cosmetic composition for improving acne, a cosmetic composition for improving acne of a hydrosol component containing lavender hydrosol and tea tree hydrosol, but not containing lavender essential oil and tea tree essential oil; To 5% by weight of tea tree essential oil, 0.1 to 5% by weight, lavender hydrosol 5 to 15% by weight and tea tree hydrosol 5 to 15% by weight of the composition characterized in that applied to the skin, Application method of the cosmetic composition for improving acne of claim 1.