KR101216596B1 - Animal skin protectants, and its manufacturing method - Google Patents

Abstract

The present invention is to protect the skin of the livestock, in particular to protect by coating the pores of the breast and teat of the cattle producing dairy products, such as cows, sheep, horses, etc., during the winter, the skin is secondary infection or wounds through the nipples The present invention relates to a livestock skin protection agent and a method of manufacturing the same, which is intended to prevent infection of bacteria and protect breasts from diseases, and to protect livestock, and to produce fresh dairy products, and to boil purified water purified by distilled water or purified water. After sterilization, the warm-level ratio process of preparing 70.6 parts by weight of hot water maintaining the temperature of 60 ℃ ~ 70 ℃, and a separate container by collecting the hot water of 60 ℃ ~ 70 ℃ prepared in the hot water preparation process at least 2 hours before the mixing time Povidone dilution step of diluting 1 part by weight of povidone to a weight ratio of water 5: povidone 1, and adding the hot water at least 2 hours before the mixing time. Xanthan gum dilution step of diluting 0.4 parts by weight of xanthan gum to a weight ratio of water 35: xanthan gum 1 in a separate container by collecting hot water prepared at a non-process, and diluting povidone prepared in the above-mentioned temperature level process. 6 parts by weight of the polymer as a coating agent in the remaining 60 ℃ ~ 70 ℃ hot water used in the process and xanthan gum dilution process, hot water diluted with povidone in the povidone dilution process, 15 parts by weight of glycerin, xanthan in the xanthan gum dilution process A mixing step of adding and diluting the hot water diluted with the gums in order, and a stirring step of adding the compound sufficiently mixed in the mixing step to a sealed stirrer, adding 7 parts by weight of ethyl alcohol to the mixture and stirring at least 24 hours; , A packaging step of packaging the animal skin protectant obtained by the stirring step into a container as a product, water 70.6 parts by weight, polymer 6 parts by weight, povidone 1 part by weight, glycerin 15 It is composed of parts by weight, xanthan gum 0.4 parts by weight, and 7 parts by weight of ethyl alcohol, while the polymer acts as a coating agent to prevent pores, while povidone acts as a disinfectant to prevent bacteria from invading into the open pores. It prevents nipples from cracking and has excellent adhesive force due to the viscosity of xanthan gum, which does not flow down when applied, as well as its excellent retention effect.It also increases the disinfection effect by the action of ethyl alcohol and also protects breasts and nipples for milking. It is easy to wipe off and remove the skin protector that was used and applied easily when wiping, and there is no risk of deterioration even if it is stored for a long time when adding preservative bronopol, and adding food coloring to it makes it easy to use the present invention. Can be easily identified to users so that they can be taken or injected It is not a method that can be found in practical use, such as preventing livestock infections and diseases caused by bacterial infection in the pore or rupture of livestock by simply applying it to the breasts and nipples every time the milker directly milks. It is a novel invention having an effect.

Food coloring, Bronopol, Polymer (Unithan-E50), Povidone (iovidin), Glycerin (Glycerin), Xanthan gum, Ethyl alcohol (Ethanol)

Description

Animal skin protectants, and its manufacturing method

The present invention is to protect the skin of the livestock, in particular to protect by coating the pores of the breast and teat of the cattle producing dairy products, such as cows, sheep, horses, etc., during the winter, the skin is secondary infection or wounds through the nipples The present invention relates to a livestock skin protection agent and a method of manufacturing the same, which aims to prevent infection of bacteria to protect breasts from diseases and to protect livestock and to produce fresh dairy products.

In livestock, all skin is protected by hair, while nipples and breasts are exposed without hair. Therefore, all livestock were exposed to breasts and nipples in winter, which not only damaged the skin, but also caused infections of the bacteria and secondary mastitis.

In particular, cattle producing milk are milked every day, and after milking, the pore has been opened for about 2 hours or more, so that the occurrence of diseases such as mastitis due to the secondary infection through the pore was not ignored.

Therefore, antibiotics are commonly used to treat mastitis in domestic animals.

Mastitis only by inhibiting the proliferation of pathogens in the breast, milk, and teats by injecting antibiotics into the breast over several days to a week and by injecting antibiotics into muscles, veins, or arteries, depending on the intended use It is a way to heal.

Another method of treatment is the use of antibiotics for the treatment, prevention and growth effects of livestock diseases. Today, the damage caused by misuse of antibiotics is at a serious level.

For example, depending on the symptoms of the veterinarian, antibiotics that should be appropriately administered according to the veterinary diagnosis result in mutant pathogenic microorganisms that have become antibiotic resistant due to the inadequate use of formulated feed or livestock farmers. In addition, there is a medical report that one of the causes of antibiotic resistance is more than four times higher than that of developed countries due to the absence of antibiotics.

As an alternative to the above, probiotic, which inhibits pathogenic microorganisms by ingesting beneficial microorganisms in the intestines of livestock, has been widely distributed in domestic livestock farms.

Conventional methods for producing such probiotics are generally products in the form of fermenting microorganisms in the liquid phase and mixing them with excipients and simply drying them.

In addition, for decades, various (immune) attempts have been made to increase the production of immunogen-specific antibodies through the mammary gland of livestock, which attempts not only to mass-produce immunogen-specific antibodies through milk. In part, infection in the mammary gland, such as mastitis (Guidry et al., J. Dairy Sci. 77 (10): 2965-2974 (1994); Pighetti et al., J. Dairy Sci. 78 (3): 528-537 (1995)). However, antibody concentrations in mature milk are still lower (approximately on the order of magnitude) than can be obtained in colostrum (Hodgkinson et al., WO98 / 54226; Hastings, USPN5017372). Thus, the antigen-specific antibodies used in most clinical and preclinical studies are derived from colostrum and thus mainly belong to the IgG class (Tollemar et al., Bone Marrow Transpl. 23: 283-290 (1999); Bostwick et al. , USPN5,773,000; Cordle et al., USPN5,260,057)

And Patent Registration No. 10-0396022 (2003.08.14) relates to a method for producing livestock probiotics and livestock probiotics to be taken to livestock, primarily mixing a plurality of microbial cultures obtained by liquid fermentation, the microbial culture As a fermentation starter, the fermentation starter is added to a coozyme containing crab shells and fermented in a secondary manner to produce various fermentation metabolites and enzymes, as well as livestock probiotics and copper containing immunoactive substances chitin, chitosan and chitooligosaccharides. It relates to a manufacturing method.

Patent Registration No. 10-0627635 (September 18, 2006) provides a means and a method for obtaining an antibody from a mammary gland secretion product of an animal comprising administering to the animal two or more compositions which may be the same or different, wherein said composition Comprises an antigen that raised the antibody, the method comprising administering at least a first of the composition such that a high mucus and / or systemic immune response is obtained, wherein at least a second of the composition is a mammary gland of the animal And / or to glandular lymph nodes.

Patent registration No. 10-0239129 (October 19, 1999) is required to inject antibiotics into the breast for several days to a week for mastitis of livestock, a serious threat to dairy farming, raising cattle, goats and pigs. The present invention relates to an apparatus for implementing a method for treating mastitis only by inhibiting the proliferation of pathogens in the breast, oil, and papilla by injecting antibiotics into muscle, vein, or artery, depending on the use.

Patent application No. 2005-0074659 (Aug. 16, 2005) is an antiseptic and disinfectant for livestock, and it is a malic acid, sweetener and strong acidic acid as an acidic agent with potassium peroxy monosulfate which has excellent sterilization and disinfection. Sodium hexameta phosphate, which acts as a clearing of the metal tube while sulfamic acid, metal coating and containment, sodium dodecyl sulfate, an anionic surfactant that emulsifies, disperses, cleanses, antistatics, aggregates, penetrates, and bubbles the above drugs, It is a disinfectant disinfectant for livestock, consisting of sodium chloride, which promotes penetration of preservatives and drugs, flavors for eliminating the strong aroma of drugs, and coloring agents for improving the appearance of disinfectants and disinfectants, if necessary.

However, the preventive and therapeutic agents for livestock health, which have been conducted so far, have high drug costs, require long-term treatment periods, require specialized knowledge and diagnostic skills in the selection of drugs, and require advanced skills in the route of drug administration. In addition, antibiotics have a function of inhibiting the growth of bacteria, and additionally, expensive drugs are necessary to increase the natural healing power of cattle.

In particular, it can cause drug poisoning by mixing it with feed for a long time, and it is developed for the treatment of already occurring germs rather than prevention, and it is difficult to reach deep parts of the breast as it has a small amount of antibiotics. There is a tissue disorder caused by the disease, irrelevant to the treatment of free radicals caused by the production of toxins and inflammation of the infecting microorganisms in the inflammatory tissues, and resistant bacteria or myoclosis is caused by the use of antibiotics In addition, the cow's milk to be treated due to the antibiotic residues must be disposed of until the residue is no longer recognized.Therefore, there is a loss for treatment.Since antibiotics are important indicators, they can only be used under the direction of a veterinarian. there was.

A boiling point sterilization process by boiling boiled clean water purified by distilled water or purified water and then preparing a hot water having a temperature of 60 ° C. to 70 ° C. or less at 70.6 parts by weight, and 60 prepared in the hot water preparation step at least 2 hours before the mixing time. A povidone dilution step of diluting 1 part by weight of povidone to a separate container with a weight ratio of water 5: povidone 1, which is obtained in the above-mentioned temperature-level ratio step, and collecting at least 2 hours before the mixing time; Xanthan gum dilution process for diluting 0.4 parts by weight of xanthan gum in a separate container by taking water which is hot water of 60 ° C. to 70 ° C. prepared in a hot water preparation step at a weight ratio of water 35: xanthan gum 1, which is hot water prepared in the above-mentioned temperature-level ratio process. And 6 parts by weight of polymer, which is prepared in the warm-level ratio process and used in the povidone dilution process and the xanthan gum dilution process, as a coating agent in water which is 60 ° C to 70 ° C hot water, and the povidone dilution process In the povidone-diluted hot water, glycerin 15 parts by weight, the xanthan gum dilution step by adding a water mixture of xanthan dilution hot water in order to mix and seal the formulation sufficiently blended in the raw material mixing process A stirring step of adding 7 parts by weight of ethyl alcohol to the stirrer and stirring at least 24 hours or more, and a packing step of putting the livestock skin protectant obtained by the stirring step into a container and packing the product with 70.6 weight of water. To obtain an animal skin protector, characterized by consisting of 6 parts by weight of polymer, 1 part by weight of povidone, 15 parts by weight of glycerin, 0.4 part by weight of xanthan gum, and 7 parts by weight of ethyl alcohol.

In the present invention, the polymer serves as a coating agent to prevent pores, while povidone acts as a disinfectant to prevent bacteria from invading into the open pores, and prevents the breast or nipple from cracking by moisturizing with glycerin, and the xanthan gum Due to its excellent adhesive strength, it does not flow down when applied, as well as its retention effect.It also increases the disinfection effect by the action of ethyl alcohol, and it is easily applied when cleaning breasts and nipples for milking. It can be easily wiped and removed, and there is no risk of deterioration even if it is stored for a long time when bronopol is added as an antiseptic. If food coloring is added thereto, it can be easily understood whether the present invention is used or not, and thus the user can be easily identified. The cattle ranchers do not direct the livestock Simply applying milk to the breasts and nipples immediately after milking every time prevents mastitis and diseases caused by bacterial infections in the pores and ruptured areas of livestock. Invention.

When the present invention described above is described in detail on the basis of 100 parts by weight of the total blended ratio as follows.

On-level non-process;

Boil and sterilize clean water purified by distilled water or purified water, and prepare 70.6 parts by weight of hot water, which is maintained at a temperature of 60 ° C to 70 ° C.

At this time, it is best to use water as distilled water, but distilled water may cause a cost increase, so clean water purified by a water purifier or clean water that is not contaminated may be used.

 Povidone dilution process;

At least 2 hours before the blending time, a portion of water, which is hot water of 60 ° C. to 70 ° C., prepared in the hot water preparation process is taken and 1 part by weight of povidone iodine, a disinfectant and sterilizer, is placed in a separate container. Dilute to a weight ratio of phosphorus 5: povidone 1.

At this time, the amount of povidone may be increased or decreased depending on the desired bactericidal effect, but according to the experiments of the present inventors, it was found to be most economically and hygienically suitable at 1 part by weight.

Herein, the mixing time is not limited, but may be based on when the povidone is completely diluted. The fastest dilution time performed by the present inventors was 2 hours, and in many cases, it took more than 24 hours.

Wherein 5: 1 may be a weight ratio of povidone 100g to 500g of hot water, but the amount of hot water should not be a problem, but according to the experience of the present inventors, hot water and povidone should be at least 5: 1 weight ratio. Diluted sufficiently in 2 hours.

Xanthan gum dilution process;

At least 2 hours before the blending time, a portion of water, which is hot water of 60 ° C. to 70 ° C., prepared in the hot water preparation step is taken, and 0.4 parts by weight of Xanthan gum, which is harmless to the human body and viscous in a separate container, is used in the on-level ratio process. Dilute to a weight ratio of prepared hot water 35: xanthan gum 1.

At this time, the amount of xanthan gum may be increased or decreased depending on the desired viscosity, but according to the inventors' experiment, when it is 0.4 parts by weight, it was found to be most suitable for use as well as economically and sanitarily.

Herein, the mixing time is not limited, but may be based on when the povidone is completely diluted. The fastest dilution time performed by the present inventors was 2 hours, and in many cases, it took more than 24 hours.

Here, 35: 1 may be 1,500g of hot water and 40g of xanthan gum, but the amount of hot water should not be a problem, but according to the experience of the present inventors, the weight ratio of water 35: xanthan gum 1 should be at least 2 Diluted sufficiently in time.

Compounding process;

6 parts by weight of a polymer (Unithan-E50) which is prepared in the warm-level ratio process and used in povidone dilution process and xanthan gum dilution process as a coating agent for the remaining water of 60 ° C. to 70 ° C., and sterilized in the povidone dilution process. , And then mix with hot water phosphorus diluted with povidone, and 15 parts by weight of glycerin (Glycerin) as a moisturizer, and water with hot water diluted with xanthan gum having viscosity in the xanthan gum dilution process. .

At this time, the amount of the polymer and glycerin may be increased or decreased depending on the desired coating degree and the moisturizing state. According to the present inventors' experiment, it is economically and hygienic when 6 parts by weight of polymer (Unithan-E50) and 15 parts by weight of glycerin (Glycerin) are used. Of course, it appeared to be the most suitable for use.

Here, 99.7 to 99.9 parts by weight of the hot water, polymer, povidone, glycerin, xanthan gum, and ethyl alcohol prepared in the warm level ratio process and used in the povidone dilution process and the xanthan gum dilution process. Food coloring may be added in a proportion of 0.2 parts by weight of the total blending capacity, or bronopol, which is a preservative, may be added in a proportion of 0.1 parts by weight of the total blending amount.

Stirring process;

The compound sufficiently blended in the compounding step is added to a sealed stirrer, 7 parts by weight of ethyl alcohol is added thereto, and the mixture is stirred for at least 24 hours.

Here, the stirring in the sealed state is to prevent the evaporation of the ethanol, and the stirring time is not limited precisely, but it is enough to maintain a sufficiently stirred state, but the experience conducted by the present inventors is suitable for 24 hours. will be.

By carrying out the above-mentioned process, a skin protection agent composed of 70.6% by weight of water, 6% by weight of polymer, 1% by weight of povidone, 15% by weight of glycerin, 0.4% by weight of xanthan gum and 7% by weight of ethyl alcohol was obtained or obtained in this manner. The skin protector which added 0.2 weight part of food coloring to 99.9 weight part, and the skin protectant which added 0.1 weight part of bronopol which is an antiseptic | preservative further can be obtained.

Packaging process;

Livestock skin protection agent obtained by the above-mentioned temperature-level ratio process, povidone dilution process, xanthan gum dilution process, blending process, and stirring process is put into a container having a capacity or distribution for easy distribution according to the period of use, and then packaged as a product. do.
Example 1

In order to more clearly understand the present invention, a compounding amount and a process for obtaining a skin protective agent of about 10.03 kg are explained once again, and 20 g of food coloring is added to about 5,160 g of purified hot water of 60 ° C. to 70 ° C., followed by stirring. .

In the above-mentioned method, in the state where food coloring is completely solved, 10 g of bronopol which is a preservative is added again, and it mix | blends. When bronopol is fully mix | blended, 600g of polymers of a coating agent are added, and it mixes continuously.

If it is sufficiently blended by the method described above, 100 g of povidone as a disinfectant disinfectant is added and mixed with 600 g of povidone diluted with sufficient warm water to 500 g of hot water.

When the mixing is completed by the above-described method, 40g of xanthan gum having 40 viscosity is added and mixed with 1,440g of xanthan gum, which is sufficiently diluted in 1,400g of hot water.

9,330 g of the compound formulated by the above method is added to a sealed stirrer and 700 g of ethyl alcohol is added thereto, followed by stirring for 24 hours in a sealed state to complete. Wherein the addition of food coloring in the present invention is used to easily identify whether the application of moving animals without stopping in one place when using the skin protection agent completed in the present invention on the breast and nipple of the livestock, trace amount of bronopol preservative It is used to prevent the deterioration even after long-term storage of the skin protection agent obtained by the present invention, the use of a polymer to coat the pores that do not close and open for about 2 hours after milking as a coating agent when coating on the nipple. Povidone is used to kill bacteria and prevent new infections by sterilization and disinfection. Glycerin, a moisturizer, is used to moisturize the skin to prevent skin from cracking or cracking, and xanthan gum is used. Preventing the present invention from flowing down on the skin; Is done to maintain the state at the time of applying for a long time, using echil alcohol is to use so that it is of course already present invention to improve the sterilization role during application erasable.
When the animal breeder directly applies milk to the breast and nipple immediately after milking, the polymer contained in the present invention acts as a coating agent to prevent pore while the povidone acts as a disinfectant to prevent bacteria from invading into the open pores. Glycerin moisturizes to prevent cracking of breasts or nipples.Excellent adhesiveness due to the viscosity of xanthan gum prevents it from flowing down when applied, and it has excellent retention effect. The skin protectant that was easily applied and used when wiping breasts and teats for milking, as well as milking, is easily wiped off and removed, and there is no risk of deterioration even after long-term storage when adding preservative bronopol. By adding it, the user can easily grasp the use of the present invention. It is easy to prevent the mastitis and disease caused by bacterial infections in the pore or ruptured area of the livestock by simply applying it to the breast and nipple immediately after milking by the livestock farmer. Done.

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Claims (6)

A first step, which is a warm-level ratio step of preparing 70.6 parts by weight or less of hot water, which is boiled and sterilized by distilled water or purified water purified by sterilization, and The hot water prepared in the first step of the hot water preparation process is 60 ℃ ~ 70 ℃ hot water at least 2 hours before the mixing time is collected in a separate container 1 part by weight of povidone in the hot water prepared in the first step of the above-mentioned step 5: povidone A second step of the povidone dilution step of diluting at a weight ratio of 1, Water of hot water prepared at 60 ° C. to 70 ° C. prepared at least two hours before the mixing time was taken at least two hours before the blending time, and 0.4 parts by weight of xanthan gum in a separate container was prepared at the on-level ratio step. A third step, which is a xanthan gum dilution process diluting at a weight ratio of xanthan gum 1, 6 parts by weight of a polymer prepared as a coating agent in the warm water of 60 ° C. to 70 ° C., which was prepared in the first step of the on-level ratio step and used in the povidone dilution step as the second step and the xanthan gum dilution step as the third step; 4th process which is a compounding process which adds and mixes povidone-diluted hot water in the 2nd process, povidone-diluted water, 15 weight part of glycerin, and xanthan gum diluted in the 3rd process, xanthan gum dilution process sequentially , A fifth step which is a stirring step of adding a compound sufficiently blended in the compounding step of the fourth step into a sealed stirrer, adding 7 parts by weight of ethyl alcohol to it and stirring at least 24 hours; Animal skin protection agent manufacturing method characterized in that the sixth step of the packaging step of packaging the product into the product by putting the animal skin protection agent obtained in the stirring step of the fifth step sequentially. delete delete delete In the skin protection agent for livestock, which dilutes xanthan gum glycerin polymer in water to prevent spread of mastitis-causing organisms, 70.6% by weight of water, 6% by weight of polymer, 1% by weight of povidone, 15% by weight of glycerin, 0.4% by weight of xanthan gum, 79.7% by weight of ethyl alcohol and 99.7 parts by weight of bronopol And 0.2 parts by weight of food coloring to limit the amount of the animal skin protection agent. delete