KR101273969B1 - Oral composition containing capsulated perfume powder - Google Patents

Abstract

The present invention relates to a composition for oral cavity containing the encapsulated powder fragrance to enhance the refreshing feeling and persistence, and more specifically, to encapsulate the powdered fragrance that can provide the oral refreshing feeling with a water-insoluble or poorly water-soluble coating agent It relates to a composition for oral cavity, characterized in that. Powder fragrance used in the present invention has a slower rate of dilution by saliva in the oral cavity than conventional liquid fragrances, and has the effect of improving the freshness and persistence, by encapsulating the powder fragrance with a water-insoluble or poorly water-soluble coating agent formulation Stability can be improved within.

Powder fragrance, refreshing, long lasting, water insoluble or poorly water-soluble coating, capsule

Description

Oral composition containing capsulated perfume powder

The present invention relates to a composition for oral cavity containing the encapsulated powder fragrance to enhance the refreshing feeling and persistence, and more specifically, to encapsulate the powdered fragrance that can provide the oral refreshing feeling with a water-insoluble or poorly water-soluble coating agent It relates to a composition for oral cavity, characterized in that.

Generally the purpose of mix | blending a fragrance with a composition for oral cavity is to give a refreshing feeling and a refreshing feeling. The fragrance may also mask the taste or smell of the base (polishing agent, surfactant, caking additive, active ingredient, etc.). However, the liquid fragrance currently used in the composition for oral cavity is rapidly diluted by saliva in the oral cavity, it is difficult to continuously obtain the same refreshing and refreshing feeling as the first time.

U.S. Patent No. 4,071,614 describes a toothpaste encapsulated in a liquid flavor. That is, it is difficult to expect the oral sustainability of the refreshing and refreshing feeling by using a liquid fragrance or a formulation that releases fragrance when the capsule wall is broken when brushing teeth.

Republic of Korea Patent Publication No. 1997-0064589 (October 13, 1997) describes a dentifrice composition characterized in that it contains 0.01 to 10.00% by weight of a refreshing agent based on the total weight of the composition. This may improve the freshness immediately after brushing, but there is a problem in that the refreshing agent is dissolved by moisture in the toothpaste formulation and thus it is difficult to enhance the persistence of the freshness.

Accordingly, the present inventors encapsulate a powder fragrance having a relatively low solubility in saliva with a water-insoluble or poorly water-soluble coating and then formulating it into a composition for oral cavity. It was found that the powdered powder collected on the oral mucosa can remain and provide a refreshing and refreshing feeling for a long time, thereby completing the present invention.

Accordingly, it is an object of the present invention to provide a composition for oral cavity which enhances oral refreshment and persistence by containing encapsulated powdered perfume.

Still another object of the present invention is to provide a stabilization method for improving stability in the formulation of the composition for oral cavity by encapsulating the powdered perfume with a water-insoluble or poorly water-soluble coating.

In order to achieve the above object, the present invention provides a composition for oral cavity characterized in that the powdered fragrance that can provide an oral refreshing feeling encapsulated with a water-insoluble or poorly water-soluble coating agent.

Hereinafter, the present invention will be described in more detail.

In the present invention, a powdered perfume having a relatively low solubility in saliva is used. In the present invention, as a powder fragrance, menthol, vanillin, 2-isopropyl-N, 2,3-trimethylbutyric amide (2-Isopropyl-N, 2,3-) present in a solid state at room temperature trimethylbutyramide) and N-ethyl-p-methane-3-carboxamide may be used alone or in combination.

In the present invention, the powdered fragrance is used by encapsulating it with an insoluble or poorly soluble coating. In the present invention, as a coating agent, polyethylene glycol, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl ketyl cellulose, ethyl cellulose, hydroxyethyl cellulose, which are insoluble or poorly soluble in water and having a rigid structure which is destroyed by mechanical stimulation, Polyvinyl alcohol, vinylpyrrolidone, vinyl acetate polymer, polyvinyl acetal dimethylamino acetate, polymethyl methacrylate, polystyrene, bees wax, paraffin wax, carnauba wax, petroleum wax And starch (Starch) can be used one or more selected from the group consisting of.

Coating methods for encapsulating powdered perfume according to the present invention include coacervation method, spray drying method, spray cooling method, crystallization method (co-crystallization) and fluidized bed (fluidized bed) And the like, and among these, the fluidized bed method is most preferred. The fluidized bed method consists of a unit process of raw material conveying, mixing, coalescing, granulation and drying. That is, by using a fluidized bed coater while spraying the powder fragrance with flowing air, the coating solution is sprayed through a spray nozzle to prepare a powder fragrance capsule so that the powder is composed of 1: 0.25 to 10 weight ratio of the capsule and the coating agent. When the ratio of the powder flavoring agent and the coating agent is less than 1: 0.25 weight ratio, the thickness of the coating wall of the capsule becomes thin, so that the capsule is easily broken when preparing the composition for oral formulation containing the same, and the content of powder flavoring agent is greater than 1:10 weight ratio. It is relatively low, so the effect is insignificant, and it may not feel the effect of enhancing the refreshing feeling.

Powdered flavor capsules of the present invention prepared by the above method has a particle size of 100-1000㎛ in the form of a sphere, preferably has a particle size of 300-600㎛.

The present invention provides a composition for oral cavity containing the encapsulated powdered perfume. The composition for oral cavity according to the present invention preferably contains the encapsulated powdered perfume in an amount of 0.01 to 10% by weight based on the total weight of the total composition. When the content of the encapsulated powdered fragrance is more than 10% by weight, oral mucosal irritation may be expressed, and when less than 0.01% by weight, the effect may be insignificant and may not properly feel the refreshing effect.

The composition for oral cavity according to the present invention is not particularly limited in its formulation, and specific examples thereof may include formulations such as toothpaste, mouthwash, mouthwash and tooth whitening agent.

For example, toothpastes may contain abrasives, wetting agents, foaming agents, binders, sweeteners, pH adjusting agents, preservatives, active ingredients, flavoring agents, brighteners, pigments, solvents and the like.

Examples of the abrasive component include calcium carbonate, precipitated silica, aluminum hydroxide, calcium dihydrogen phosphate, and insoluble sodium metaphosphate, and are preferably 1 to 60% by weight based on the total weight of the composition, alone or in combination of two or more thereof. Preferably 10 to 50% by weight.

The humectant component includes glycerin, sorbitol liquid, polyethylene glycol, propylene glycol, and the like, and is used alone or by mixing two or more kinds thereof, using 20 to 60% by weight based on the total weight of the composition.

Foaming agents include polyoxyethylene sorbitan fatty acid esters, polyoxyethylene (cured) castor oil, glycerin fatty acid esters, sorbitan fatty acid esters, sucrose fatty acid esters, alkylolamides and alkyls to prevent the activity of cationic fungicides from decreasing. Nonionic surfactants such as glucoside; Or cationic surfactants such as N-alkyldiamino ethylglycine, alone or in combination of two or more thereof, and 0.5 to 10% by weight, preferably 0.5 to 8% by weight, based on the total weight of the composition.

As the binder, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, carrageenan, sodium alginate, etc. may be used alone or in combination of two or more, and 0.1 to 5% by weight, preferably 0.1 to 2% by weight, based on the total weight of the composition. .

As a sweetener, saccharin sodium, aspartame, stevioside, xylitol, and licorice acid are used alone or in combination of two or more, and 0.05 to 5% by weight based on the total weight of the composition.

Examples of pH regulators include sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, citric acid and tartaric acid, and preservatives such as methyl paraoxyanthine, propyl paraoxybenzoate and sodium benzoate alone or two. The above mixture is used in an amount of 0.01 to 3.0 wt% based on the total weight of the composition.

The active ingredients include sodium fluoride, sodium monofluorophosphate, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, triclosan, cetylpyridium chloride, zinc chloride, pyridoxine hydrochloride, and tocopherol acetate. It can be used by mixing two or more kinds, and a suitable amount of peppermint oil, spearmint oil, menthol and anetol can be further mixed as a fragrance, titanium oxide as a brightener, food coloring as a pigment, purified water and It is prepared according to a conventional toothpaste production method using ethanol as a solvent.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, the scope of the present invention is not limited to these.

Example 1 Preparation of Powder Menthol Capsule

500 g of powder menthol as a powder fragrance was pulverized to a size of 100-300 μm and uniformly pulverized, and then injected into a fluidized bed coater, and then sprayed with a starch liquid as a coating agent through a nozzle to coat the powder menthol surface with starch. The constituent ratio of the capsule was 1: 1 to make menthol and starch, and 1kg of powdered menthol capsule having a particle size of 300-600 μm was prepared.

Comparative Example 1 Preparation of Liquid Menthol Capsule

After dissolving 500 g of menthol in 250 g of ethanol to prepare 750 g of menthol solution, 250 g of gelatin (gelatin) was used as a coating agent to prepare a liquid menthol capsule having a particle size of 300-600 μm by coacervation method.

Formulation Example 1-2 and Comparative Formulation Example 1-2 Formulation of Toothpaste

Toothpaste of Formulation Example 1-2 and Comparative Formulation Example 1-2 were prepared according to the conventional toothpaste manufacturing method with the composition shown in Table 1 below (content: wt%).

ingredient Formulation Example 1 Formulation Example 2 Comparative Formulation Example 1 Comparative Formulation Example 2 Function 17 17 17 17 Sodium fluoride 0.22 0.22 0.22 0.22 glycerin 5 5 5 5 Sorbitol solution 45 45 45 45 Carboxymethyl Cellulose Sodium 1.0 1.0 1.0 1.0 Sodium lauryl sulfate 2.0 2.0 2.0 2.0 Methyl paraben 0.15 0.15 0.15 0.15 Spices 1.0 1.0 1.0 1.0 Powder Menthol Capsules Prepared in Example 1 0.5 1.0 - - menthol - - 0.25 - Liquid Menthol Capsules Prepared in Comparative Example 1 - - - 0.5 Titanium dioxide 0.4 0.4 0.4 0.4 Sodium saccharin 0.2 0.2 0.2 0.2 Purified water Balance Balance Balance Balance

Looking at Table 1, Formulation Example 1 and Formulation Example 2 was added to the powdered flavor capsule of Example 1 prepared in the present invention, Comparative Formulation Example 1 was added to the same amount of powder menthol instead of powdered flavor capsules. In Comparative Formula 2, the liquid menthol capsule of Comparative Example 1 containing the same amount of menthol was blended instead of the powdered flavor capsule.

Test Example 1 Sensory Evaluation of Cooling Feel

In this test, the following sensory evaluation was performed to determine the refreshing feel of the toothpaste prepared in Formulation Example 1-2 and Comparative Formulation Example 1-2.

First, 30 test subjects (25-35 years old) who received 1 g of toothpaste of Formulation Example 1-2 and Comparative Formulation Example 1-2 after toothpaste to toothbrush moistened with saliva and were trained for oral refreshing sensory evaluation after 1 week 10 men and 20 women) were brushed for 3 minutes, washed 5 times with water, and then measured on a 5-point scale immediately after brushing, 30 minutes, 1 hour, 2 hours and 3 hours after brushing. And, the sensory evaluation results for the refreshing feeling are shown in Table 2 below. At this time, the food intake was prohibited during the measurement time after brushing.

Refreshing index (five points scale) Formulation Example 1 Formulation Example 2 Comparative Formulation Example 1 Comparative Formulation Example 2 Immediately after brushing 4.0 4.5 3.9 3.9 30 minutes later 3.7 4.1 3.5 3.4 After 1 hour 3.5 3.8 3.2 3.3 After 2 hours 3.3 3.6 2.8 2.7 After 3 hours 3.2 3.4 2.4 2.5

Evaluation method: very good 5, good 4, normal 3, bad 2, very bad 1

As can be seen in Table 2, Formulation Example 1 and Formulation Example 2 to which the powdered flavor capsules prepared in Example 1 was added, Comparative Liquid Formula 1 and Comparative Example 1 added liquid menthol capsules of powder menthol Compared to Comparative Formulation Example 2, the refreshment index score was higher and the persistence score was much higher. According to the amount of powdered flavoring capsules added, the freshness and persistence increased, and Comparative Example 1 containing the same amount of menthol and Comparative Example 2 encapsulating the liquid menthol obtained similar results.

Test Example 2 Evaluation of Powder Menthol Stability in Toothpaste Formulation and Changes of Menthol Content in Capsules Over Time

In this test, the following tests were carried out to evaluate the change of powder menthol stability in dentifrice formulations and the menthol content in capsules over time when powdered flavor capsules were used.

First, the toothpaste of Formulation Example 1 and Comparative Formulation Example 1 were stored in a constant temperature room for one week, one month, and three months at 0, 30, 40, and 50 ° C., respectively, and then compared to powder menthol stability. For Formulation Example 1, the stability and menthol content of the powdered menthol capsules were confirmed by visual observation and gas chromatography analysis, respectively, and the results are shown in Table 3 below. The menthol content is expressed in weight percent relative to the initial blending amount. In the case of Comparative Formulation Example 1, it was difficult to confirm the stability of powder menthol in appearance, and the presence of menthol powder could be confirmed by rubbing the toothpaste by hand immediately after the manufacture, but when it was checked again after one week, the menthol powder was not felt. In addition, it was found that they could not be retained in the toothpaste formulation and dissolved.

Temperature (℃) 1 week 1 month 3 months 0 Stable (100%) Stable (100%) Stable (100%) 30 Stable (100%) Stable (100%) Stable (100%) 40 Stable (100%) Stable (100%) Stable (99%) 50 Stable (100%) Stable (100%) Stable (98%)

Appearance evaluation method: stable capsule shape, unstable capsule shape

As can be seen in Table 3, it can be seen that the aging change of the stability of the powder menthol and the menthol content in the capsule is stable in the toothpaste formulation of Formulation Example 1.

As described above, the composition for oral cavity according to the present invention encapsulates a powder fragrance having a lower solubility than a liquid perfume with a water-insoluble or poorly water-soluble coating agent to ensure long-term stability in the oral composition containing water during physical use. As the coating was broken by force, the powdered fragrance was attached to the oral mucosa and remained to provide a refreshing and refreshing feeling for a long time.

Claims (5)

Powder flavoring encapsulated with a coating agent based on the total weight of the composition of 0.01 to 10% by weight, The coating agent is polyethylene glycol, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl ketyl cellulose, ethyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, vinylpyrrolidone, vinyl acetate polymer, polyvinyl acetal dimethylamino acetate, polymethyl At least one member selected from the group consisting of methacrylate, polystyrene and starch, The powdered perfume is menthol (Menthol), vanillin (Vanillin), 2-isopropyl-N, 2,3-trimethylbutyramide (2-Isopropyl-N, 2,3-trimethylbutyramide) in a solid state at room temperature and N-ethyl-p-methane-3-carboxamide (N-Ethyl-p-methane-3-carboxamide) is one or more selected from the group consisting of The encapsulated powdered flavor is a composition for oral cavity having a particle size of 300 ~ 600㎛. delete delete The composition for oral cavity of claim 1, wherein the encapsulated powdered perfume is composed of a powdered perfume and a coating agent in a weight ratio of 1: 0.25 to 10. delete