KR101402949B1 - Genetic biomarkers and DNA chip for analysing for asthma and atopy diseases - Google Patents

Abstract

TECHNICAL FIELD The present invention relates to biomarkers for diagnostic genomes in asthma and allergic diseases and DNA chips containing the same.

According to the present invention, gene expression analysis using gene chips showed that 79 genes were increased-regulated by asthma and allergic diseases, 51 genes were increased in expression, and 28 genes were decreased in expression. Nine of these 79 genes were identified by quantitative real-time gene-amplification (RT-PCR) analysis and these gene indices will be used as useful genomic biomarkers for asthma and atopic disease. In addition, the genome bioindicator genes can be used for the development of a DNA chip or a measurement kit for diagnosis related to asthma and atopic disease.

Diagnosis of asthma and atopy disease Diene chips, asthma and atopy disease diagnosis kit

Description

TECHNICAL FIELD The present invention relates to a diagnostic biomarker gene for asthma and allergic diseases, and a DNA chip for analyzing the same,

The present invention relates to a diagnostic biomarker gene for asthma and atopic disease and a DNA chip comprising the same. More particularly, the present invention relates to a genome biomarker related to asthma and atopic disease associated with environmental pollutants, .

In recent years, genomics, particularly the field derived from this, toxic genomics appears to be a rapidly evolving technology enabling the study of the effects of chemicals and drugs, especially on gene expression in biological systems (Corvi 2002). The widespread application of the DENE chip technology to toxicology has provided efficient research tools by merging with traditional toxicological methods that are likely to produce various biomarkers of toxic chemicals. Therefore, in the present invention, a genome analysis using a DNA chip was conducted to identify which biomarkers are associated with diseases in asthma and atopic diseases exposed to air pollutants.

      Health problems caused by air pollution can be roughly divided into three categories. The first is already known respiratory diseases such as asthma, and the second is heart disease (Pope et al, 2004). The third is the allergic immune response (Granum & Lovik, 2002). The most important mechanism of respiratory disease caused by air pollutants is inflammation of lung epithelium and increased production of cytokines. The most important mechanism of this reaction is oxidative stress (Stringer & Kobzik, 1998). The chemical syndromes due to indoor pollution, which is a recent problem, are similar to the existing Sick Building Syndrome or Multiple Chemical Sensitivity, but there is no established method for evaluating the exact cause or human influence. However, various indoor pollutants causing indoor pollution are reported to cause oxidative stress. (2003), tobacco smoke (Howard et al, 1998), heavy metals (Merzenich et al, 2001) and cooking oil fumes (Tung et al, 2001) Oxidative stress is also a major mechanism in the case of substances (McBride et al, 2003). In the present study, the effects of multiple chemical sensitivities were investigated in the 1980s (Lee et al, 2003; Shinohara et al, 2004).

     Therefore, the major diseases caused by various indoor and air pollutants can be classified into respiratory diseases, allergies, and chemical syndromes, which are typified by asthma. In order to evaluate these diseases, Content can be central. In addition to indoor and air pollution, oxidative stress, immune disorders, etc., as well as these diseases, may be caused by other causes (Eriksson et al, 1999), for example, . In addition, there may be different patterns depending on the amount and distribution of indoor and air pollutants, and various pollutants cause oxidative damage, but the target at the molecular level may be different (Halliwell & Cross, 1994). Although there is a genetic difference in susceptibility to oxidative stress (Forsberg et al., 2001), even if exposed to the same level of pollutants, the difference in genetic expression through DNA chip techniques It is necessary to develop a genomic biomarker related to the disease. On the other side, new diseases may appear due to indoor and air pollutants, but existing diseases are exacerbated and an evaluation is needed (Stringer & Kobzik, 1998).

 I. Current Status of Domestic and Foreign Related Technologies

  1) Overseas

Most of all, research on environmental pollution and allergies has been carried out. Especially, studies on children have been focused (Richter & Pfeifer, 1993; Rumiantseva & Dmitriev, 1999). Studies on bronchial inflammation and asthma by air pollutants have been conducted to inhibit the production of IgE for the treatment of this disease. There have been attempts to apply the humanized IgE antibody (mAb-E25) in the treatment of these diseases at the University of Southampton in England, but the effect has been insignificant. Interestingly, Salvi et al. Of the same university have now reported that glucocorticoids or β Antagonists of the 2-adrenergic receptor have been reported to significantly increase the amount of IgE despite alleviating the symptoms of asthma. The results of a study on the role of NKT cells producing IL-4 and IL-13 in bronchial hyperresponsive animal models induced by allergens have been reported by Stanford University on March 30, 2003 Nature And reported that allergen-specific Th1 cells do not inhibit Th2-induced airway hyperresponsiveness, but rather cause more severe airway inflammation at Stanford University. These studies are expanding their understanding of the allergic reaction by environmental pollutants. A number of studies have been reported on individual exposure assessment techniques and health impact assessment techniques, and studies evaluating exposure comprehensively at home are the well-known US National Human Exposure Assessment Survey (NHEXAS) study (Walker et al, 2003 ; Calyton et al, 2002). There were no comprehensive studies evaluating various exposure and health impact indicators, and no studies conducted with genomic and proteomic studies were found.

  2) Domestic

   The research on indoor and air pollution reported in domestic journals is either epidemiologic or risk-oriented (Jong-Tae, 2003; Lim Hyun-joon, 2003; (2003) investigated the effects of genetic diversity on urinary 1-hydroxypyrene induced by exposure to PAH, but also assessed overall exposure to indoor and air pollution exposure and molecular levels of oxidative stress I could not find anything. Except for cell experiments and animal experiments with toxic substances, molecular and epidemiological studies of human lung diseases and asthma due to indoor and air pollutants were not found. The researchers at SNU investigated the effects of methacholine on inflammation rather than bronchial hyperresponsiveness in patients with allergic rhinitis We have published a paper that suggests that the maximal increase in airway response by mediators can be a predictor of asthma development.

   All. Differences from domestic and overseas similar technologies

    The most similar study among domestic and international studies is the NHEXAS study of the United States, which carried out an exposure assessment study for the entire family at home. However, the NHEXAS study was an exposure-centered study and did not directly assess the health effects of exposure. The present invention relates to a method for evaluating gene expression by comparing and evaluating patient groups such as asthma and atopy with respect to oxidative stress and immune function and related genetic factors, It is about markers.

   la. Commercialization of invention

   The use of specific biomarkers for disease-specific diseases, such as asthma, respiratory diseases, allergic diseases, and environmental chemicals, to establish a system for tracking environmental pollutants and to evaluate human impacts. It is expected that it will be developed and commercialized as a human influence assessment diagnostic kit which can be used easily by many ordinary people along with promptness and accuracy in human health impact assessment by manufacturing the probe. In addition, comprehensive exposure-impact assessments will develop relatively specific impact indicators related to exposure to indoor and air pollutants, and intensive cytokine expression studies involving respiratory diseases, allergic patients, and chemical sensitizers due to environmental air pollutants There is a possibility of commercialization that can develop new immune related genome biomarkers through development of genetic chip for the above specific diseases.

   hemp. Expected effects and utilization plan in technology development

   The development of novel genomic biomarkers that can assess oxidative stress comprehensively can provide fundamental research results that reveal the mechanism of oxidative damage specific to indoor and air pollutants. Since oxidative damage is a cause of many diseases, understanding the degree of oxidative damage due to indoor and air pollution can provide a way to understand and prevent diseases associated with oxidative damage. Therefore, it is possible to contribute to the promotion of public health by developing a method to monitor health effects such as asthma and atopy from a preventive level as an oxidative damage center. Allergy and other immune diseases are increasing diseases in developed countries. It is known that environmental pollution is an important cause, but there is a lack of research on precise mechanisms. This study aims to provide a comprehensive assessment of indoor and air pollution and new immunity indicators to understand the mechanism of newly emerging immune diseases and to draw out research results that can prevent them, And can contribute greatly to treatment.

TECHNICAL FIELD The present invention relates to biomarkers for diagnostic genomes in asthma and allergic diseases and a DNA chip containing the same. More specifically, the present invention relates to gene expression analysis in a control group and a patient group by applying a DNA chip technology from asthma and allergic diseases, The present invention relates to genetic biomarkers for diagnostic genomics,

It is another object of the present invention to provide a DNA chip or kit for evaluating toxicity against asthma and atopy due to environmental harmful / toxic substances using the genome biomarkers.

The present invention is based on the analysis of gene expression in control and patient groups by applying the DENE chip technology from asthma and atopy disease and real-time gene amplification to identify diagnostic genome biomarkers, As an effective ingredient, as a genome biomarker for diagnosing asthma and atopic disease. In Table 1 below, the item "No. " refers to the sequence number.

In the present invention, the change in gene expression in asthma and atopic disease means that the expression of the gene is regulated up or down. In addition, the nucleotide sequence of these genes can be obtained from known NCBI.

According to another aspect of the present invention, there is provided a DNA chip for diagnosing asthma and atopic disease, which comprises at least one probe for a genome bioelement according to the present invention on a substrate.

In the present invention, preferably, the probe is selected from oligonucleotides having the nucleotide sequences of SEQ ID NOS: 79 to 148, and a DNA chip for diagnosis of asthma and atopic disease.

According to another aspect of the present invention, there is provided an RT-PCR kit for the detection of formaldehyde exposure comprising at least one primer capable of amplifying the genome bioindicative according to the present invention.

In the present invention, preferably, the primer is selected from oligonucleotides having the nucleotide sequences of SEQ ID NOS: 79 to 148, and an RT-PCR kit for diagnosing asthma and atopic disease.

The oligonucleotides having the nucleotide sequences of SEQ ID NOS: 79 to 148 of the present invention are specifically bound to genomic biomarkers having the nucleotide sequences of SEQ ID NOS: 1 to 78 derived from peripheral blood whose expression varies according to asthma and atopic disease The probe can be used as a primer sequence capable of specifically RT-PCR amplifying the genomic bioindexes, and as a probe sequence capable of specifically hybridizing with the biomarker genes.

In the DNA chip of the present invention, the probe may be a nucleic acid such as a deoxyribonucleotide (DNA), a ribonucleotide (RNA) as well as a peptide nucleotide (PNA), a lactocynucleotide (LNA) and a dihexitol nucleotide ). ≪ / RTI > The nucleic acid analogue is stable to an enzyme such as a nuclease, has a structure-specific binding to a nucleotide sequence, and has a heat-stable advantage. That is, since the oligonucleotide of the present invention is characterized by its base sequence capable of hybridizing with the target sequence, it should be understood that the oligonucleotide includes the nucleic acid analogue as long as it has the same base sequence as the base sequence.

In the DNA chip of the present invention, the probe may be made for sense or antisense. Thus, the oligonucleotide may have the nucleotide sequence of SEQ ID NOs or a sequence complementary thereto.

In the microarray of the present invention, the support may be a slide glass, a plastic, a membrane, a semiconductor chip, a silicone, a gel, a nano material, a ceramic material, an optical fiber, . The microarray of the present invention can be produced by a conventional pin DNA chip (Microarray printing technology, Don Rose, Ph.D., Cartesian Technologies, Inc., Anal Biochem, 320 (2): 281-91 (2003)), ink jet (Nat Biotech, 18; 438-441 (2000), Bioconjug Chem, 13 (1); 97-103 (2002)), photolithography (Cur Opinion Chem Biol, 2: 404-410 (1998), Nature genetics supplement, 21: 20-24 (1999)) or electric arrays (Ann Biomed Eng. 20 (4): 423-37 (1992), Psychiatric Genetics, 12; 181-192 (2002)).

When the microarray of the present invention is provided in the form of a diagnostic kit, it may contain, in addition to the microarray of the present invention, an extraction reagent for separating target DNA, a PCR kit containing a primer for amplifying a target gene, a hybridization reaction solution, A solution for washing reactive DNA, a cover slip, a dye, a solution for non-dyed bond cleansing solution, and instructions for use.

In the method for diagnosing asthma and atopy disease using the DNA chip of the present invention, the nucleic acid can be separated using conventional DNA or RNA separation methods or kits, and DNA amplification can be performed by conventional PCR or RT-PCR The PCR detection method may be performed by an electrophoresis analysis method using conventional agarose gels or the microarray signal detection may be performed using a scanner for fluorescent dye binding and signal detection such as Cy5 or Cy3 .

As described above, 79 gene genome biomarkers were found in asthma and atopic disease in the gene expression analysis using the DENE chip, showing that 51 of the genome biomarkers were increased-regulated and 28 genes were decreased-regulated . Thirty genomic biomarkers of these 79 genes were identified by quantitative real-time gene amplification (RT-PCR) analysis and these genes will be provided as useful genomic biomarkers for asthma and atopic disease. In addition, the genome bioelements can be used for the development of a DNA chip or a portable measurement kit for diagnosing human diseases associated with asthma and atopic diseases.

Hereinafter, the present invention will be described in more detail with reference to Examples. These embodiments are only for illustrating the present invention, and thus the scope of the present invention is not construed as being limited by these embodiments.

Example  1: Materials and experimental design

 (1) Peripheral blood samples were collected from control, asthmatic and atopic patients, and RNA was extracted. A control group (74 samples), asthma (52 samples) and atopy (12 samples) were obtained.

Control group asthma Atopic dermatitis division 74 mild 16 mild 2 moderate 20 moderate 9 severe 6 severe One Etc 10 Etc Sum 74 52 12

(A) List of control group

Control group SNo. ID SNo. ID SNo. ID One One 26 30 51 60 2 2 27 31 52 61 3 3 28 32 53 62 4 4 29 33 54 63 5 5 30 34 55 65 6 6 31 35 56 68 7 7 32 36 57 69 8 9 33 38 58 71 9 10 34 40 59 72 10 11 35 41 60 73 11 12 36 42 61 74 12 13 37 43 62 75 13 14 38 44 63 77 14 16 39 45 64 79 15 18 40 46 65 80 16 19 41 47 66 81 17 20 42 48 67 82 18 21 43 49 68 83 19 23 44 50 69 84 20 24 45 51 70 87 21 25 46 53 71 89 22 26 47 55 72 90 23 27 48 56 73 91 24 28 49 57 74 92 25 29 50 58 Sum 74

 (B) A list of asthma patients

asthma No . SNo ID Severity No . SNo ID Severity One R101 door** moderate 27 R127 Hong ** mild 2 R102 River** moderate 28 R128 this** moderate 3 R103 south** severe 29 R129 tablet** moderate 4 R104 within** severe 30 R130 Choi ** mild 5 R105 Kim** severe 31 R131 this** mild 6 R106 God** moderate 32 R132 One** moderate 7 R107 this** severe 33 R133 River** mild 8 R108 core** severe 34 R134 Yun ** mild 9 R109 Kim** moderate 35 R135 Min ** mild 10 R110 River** moderate 36 R136 Kim** mild 11 R111 being** moderate 37 R137 Kim** moderate 12 R112 foil** moderate 38 R138 back** mild 13 R113 Kim** moderate 39 R139 Kim** moderate 14 R114 River** moderate 40 R140 south** mild 15 R115 Ha ** moderate 41 R141 being** mild 16 R116 phrase** mild 42 R142 chapter** moderate 17 R117 Kim** mild 43 R143 this** female 18 R118 Kim** severe 44 R144 south** south 19 R119 this** mild 45 R145 foil** south 20 R120 Degree** moderate 46 R146 Kim** female 21 R121 I** moderate 47 R147 article** female 22 R122 this** mild 48 R148 foil** south 23 R123 being** mild 49 R149 Choi ** south 24 R124 foil** moderate 50 R150 this** female 25 R125 being** moderate 51 R151 Kim** south 26 R126 this** mild 52 R152 this** south

(C) List of samples for atopic patients

Atopic dermatitis No SNo ID Severity No SNo ID Severity One R201 south** mild 8 R208 foil** severe 2 R202 Kim** moderate 9 R209 chapter** moderate 3 R203 article** moderate 10 R210 article** moderate 4 R204 female** moderate 11 R211 River** moderate 5 R205 foil** mild 12 R212 week** moderate 6 R206 Kim** moderate 7 R207 High ** moderate

Example  2: RNA  extraction

Total RNA was extracted from the peripheral blood of patients with asthma and atopy using TRISol reagent (Invitrogen, USA) by the manufacturer and stored at -80 ° C until use. The concentration and purity of the RNA were measured by a spectrophotometer at 260 nm and analyzed by Agilent bioanalyzer.

After adding 500.0ul of TRIzol to each sample, it was shredded using a 23 gauge syringe, 100.0ul chloroform was added, and the mixture was smoothly transferred and mixed and centrifuged at 12,000g for 15 minutes. The supernatant was placed in a clean centrifuge tube and equilibrated with isopropanol, mixed, left at room temperature for 10 minutes, and centrifuged at 12,000 g for 10 minutes. After removal of the supernatant, 500.0 ul of 75% ethanol was added to the pellet, centrifuged at 7,500 g for 5 minutes, and the supernatant was removed again. After the pellet was completely dried in the air, a DEPC-treated buffer was added to separate the total RNA. The isolated total RNA was isolated using a MicroPoly (A) Purist (Ambion Co.) kit and stored at -70 ° C until use.

Example  3: Microarray  Analysis of gene expression using

Gene expression was analyzed by using the total human genomic microarrays of illumina (48,000 genes; Illumina, San Diego, Calif., USA) and according to the method provided by the manufacturer. To construct first-strand cDNA, 2.0ul of 16.7ng / ul combined spike solution, 1.0ul of T7 oligo-dT primer and 2.0ug of total RNA were added, and 12.0ul of nuclease-free water was added, After incubation, 2.0ul of 10x first-strand buffer, 4.0ul of 5mM dNTP mix, 1.0ul of RNase inhibitor and 1.0ul of reverse transcriptase were added and incubated at 42 ° C for 2 hours. To prepare second-strand cDNA, 10.0 μl of 10 × second-strand buffer, 4.0 μl of 5 mM dNTP mix, 2.0 μl of DNA polymerase mix, and 1.0 μl of RNase H were added to 20.0 μl of first strand cDNA and then 100 μl of nuclease-free water ul. After incubation at 16 ° C for 2 hours, the cells were purified using QIAGEN purification kit. To prepare cRNA, 4.0 μl of 10 × T7 reaction buffer, 4.0 μl of T7 ATP solution, 4.0 μl of T7 GTP solution, 4.0 μl of T7 CTP solution, cDNA solution is added to 4.0ul of solution, 7.5ul of 10mM biotin-11-UTP, 4.0ul of 10x T7 enzyme mix, and incubated at 37 ° C for 14 hours. The synthesized cRNA was purified using a QIAGEN RNeasy mini kit and the OD value at 260 nm was measured to confirm that the A260: A280 ration was 1.8 or more and 2.1 or less. The hybridization was performed by adding 5.0 μl of 5 × fragmentation buffer to 10.0 μg of cRNA, heating at 94 ° C for 20 minutes, 260ul of hybridization solution, denaturation at 90 ° C for 5 minutes, loading on microarray, Hybridization was performed in a 300 rpm shaker incubator for 18-24 hours. For post-hybridization washing, microarray was placed in 13 ml of 0.75 × TNT buffer overnight at 46 ° C, and incubated for 1 hour. After removing 0.75 × TNT buffer, 3.4 ml of Cy5-streptavidin working solution was added, For 30 minutes. The microarray was washed in 240 ml filtered 1 × TNT buffer for 5 minutes and then gently washed with rinse solution (0.1 × SSC / 0.05% Tween 20) to remove water and analyzed with a scanner (Scanarray 5000, Biorobotics, UK).

Example 4 : RT - PCR  Dielectric Statistical Analysis

Genomic biomarkers were analyzed by GeneSpring GX ver. 9.0 and related genes were selected. (Fig. 1)

Example  5: Realtime ( Real time ) RT - PCR

Gene expression was verified using SYBR Green fluorescence on a Roche LightCycler system (LC480, Roche Diagnostics, Germany) instrument for selected genes with differences in gene expression analyzed in the chip. The genes analyzed by Lightcycler were analyzed by relative CT method for relative gene expression. In real-time PCR, 2.0 μl of 10x buffer (50 mM KCl, 10 mM TrisHCl (pH 8.3), 0.001% gelatin), 2.0 μl of 2.5 mM MgCl ₂ and 1.6 μl of 2.5 mM dNTP , 1.0 μl of 5 'primer (10 pmol / μl), 1.0 μl of 3' primer (100.4 μl of amplitaq (5 U / ml), 1.0 μl of SYBR Green I (Molecular probes) cDNA was mixed with 10.0 μl of distilled water under the following conditions: denaturation at 95 ° C for 3 minutes, 52 ° C for 5 seconds, and 72 ° C for 12 seconds. For 3 minutes, and the PCR was repeated 40 times at 54 ° C for 5 seconds and at 72 ° C for 12 seconds. The nucleotide sequences of the primers are shown in Table 1 below. Was confirmed to show a single amplicon in 2.0% agarose. A negative control of real-time PCR was included in each experiment W analyzed. Quantitative analysis of polymerase chain reaction was analyzed by lightcycler version 4.0 program was each PCR reaction is verified by melting curve analysis using LightCycler instrument.

(1) a primer base sequence used in real-time PCR

asthma Atopic dermatitis gene sequence gene sequence ERAF 5'-cctcaagagtgtgggtgagac-3 '(SEQ ID NO: 79)
5'-tccttattggccttaagaagagc-3 '(SEQ ID NO: 80) IL1R2 5'-tacgcaccacagtcaaggaa-3 '(SEQ ID NO: 127)
5'-aagaaggccagtgaaagtgg-3 '(SEQ ID NO: 128) CAMP 5'-tcggatgctaacctctaccg-3 '(SEQ ID NO: 81)
5'-gtctgggtccccatccat-3 '(SEQ ID NO: 82) IL2RA 5'-acgggaagacaaggtggac-3 '(SEQ ID NO: 129)
5'-tgcctgaggcttctcttcac-3 '(SEQ ID NO: 130) MCEMP1 5'-gaggctgggattccgttc-3 '(SEQ ID NO: 83)
5'-ttttctgtacctttgtgtcaacg-3 '(SEQ ID NO: 84) IL8RB 5'-gaggcacagtgaagacatcg-3 '(SEQ ID NO: 131)
5'-aggacacctccagaagagca-3 '(SEQ ID NO: 132) SEPP1 5'-ttcctcctcttccacctcct-3 '(SEQ ID NO: 85)
5'-acaaacacatacagaataaaccaagg-3 '(SEQ ID NO: 86) IL8 5'-agacagcagagcacacaagc-3 '(SEQ ID NO: 133)
5'-atggttccttccggtggt-3 '(SEQ ID NO: 134) CTSS 5'-ctcatacgatctgggcatga-3 '(SEQ ID NO: 87)
5'-gggaactctcagggaactca-3 '(SEQ ID NO: 88) KLF6 5'-aaagctcccacttgaaagca-3 '(SEQ ID NO: 135)
5'-ccttcccatgagcatctgtaa-3 '(SEQ ID NO: 136) IL1R2 5'-tacgcaccacagtcaaggaa-3 '(SEQ ID NO: 89)
5'-aagaaggccagtgaaagtgg-3 '(SEQ ID NO: 90) RGS1 5'-tgaaatcttccaagtccaagg-3 '(SEQ ID NO: 137)
5'-ttccaaagacattttgaccagtt-3 '(SEQ ID NO: 138) NCF4 5'-tcagcaccatcaaggacatc-3 '(SEQ ID NO: 91)
5'-cagagctatgtcctctctctgga-3 '(SEQ ID NO: 92) IL2RG 5'-tgctaaaactgcagaatctggt-3 '(SEQ ID NO: 139)
5'-agctgggattcactcagtttg-3 '(SEQ ID NO: 140) TREM1 5'-ctgaaatcaaccttacaaatgtgac-3 '(SEQ ID NO: 93)
5'-gctcttactcaggaatccacca-3 '(SEQ ID NO: 94) FASLG 5'-gctggcagaactccgaga-3 '(SEQ ID NO: 141)
5'-ttttcagggggtggactg-3 '(SEQ ID NO: 142) IL8RB 5'-gaggcacagtgaagacatcg-3 '(SEQ ID NO: 95)
5'-aggacacctccagaagagca-3 '(SEQ ID NO: 96) IFNG 5 'gcattttgaagaattggaaag-3' (SEQ ID NO: 143)
5'-tttggatgctctggtcatctt-3 '(SEQ ID NO: 144) TNFRSF17 5'-tgcataccttgtcaacttcgat-3 '(SEQ ID NO: 97)
5'-cctttcactgaattggtcacac-3 '(SEQ ID NO: 98) CCL8 5'-ccctcagggacttgctcag-3 '(SEQ ID NO: 99)
5'-ctccagcctctggataggaa-3 '(SEQ ID NO: 100) IFI27 5'-ggtgaggtcagcttcacattc-3 '(SEQ ID NO: 145)
5'-ggttaattccgtggcctaga-3 '(SEQ ID NO: 146) INFr 5'-ggcattttgaagaattggaaag-3 '(SEQ ID NO: 101)
5'-tttggatgctctggtcatctt-3 '(SEQ ID NO: 102) HAMP 5'-ctgttttctcacaacagacg-3 '(SEQ ID NO: 147)
5'-tctggaacatgggcatcc-3 '(SEQ ID NO: 148) STAT1a 5'-gactgagttgatttctgtgtctgaa-3 '(SEQ ID NO: 103)
5'-acacctcgtcaaactcctcag-3 '(SEQ ID NO: 104) STAT1b 5'-ttggcacctaacgtgctg-3 '(SEQ ID NO: 105)
5'-ttcgtaccactgagacatcctg-3 '(SEQ ID NO: 106) CCL13 5'-accttcaacatgaaagtctctgc-3 '(SEQ ID NO: 107)
5'-ggacgttgagtgcatctgg-3 '(SEQ ID NO: 108) IFI27 5'-ggtgaggtcagcttcacattc-3 '(SEQ ID NO: 109)
5'-ggttaattccgtggcctaga-3 '(SEQ ID NO: 110) IL2RA 5'-acgggaagacaaggtggac-3 '(SEQ ID NO: 111)
5'-tgcctgaggcttctcttcac-3 '(SEQ ID NO: 112) IL6 5'-gatgagtacaaaagtcctgatcca-3 '(SEQ ID NO: 113)
5'-ctgcagccactggttctgt-3 '(SEQ ID NO: 114) IL8 5'-agacagcagagcacacaagc-3 '(SEQ ID NO: 115)
5'-atggttccttccggtggt-3 '(SEQ ID NO: 116) KLF6 5'-aaagctcccacttgaaagca-3 '(SEQ ID NO: 117)
5'-ccttcccatgagcatctgtaa-3 '(SEQ ID NO: 118) RGS1 5'-tgaaatcttccaagtccaagg-3 '(SEQ ID NO: 119)
5'-ttccaaagacattttgaccagtt-3 '(SEQ ID NO: 120) FASLG 5'-gctggcagaactccgaga-3 '(SEQ ID NO: 121)
5'-ttttcagggggtggactg-3 '(SEQ ID NO: 122) IFNG 5'-ggcattttgaagaattggaaag-3 '(SEQ ID NO: 123)
5'-tttggatgctctggtcatctt-3 '(SEQ ID NO: 124) FADD 5'-cagagcccatgctcaacc-3 '(SEQ ID NO: 125)
5'-acatcctttctgccaactgc-3 '(SEQ ID NO: 126)

(2) real-time PCR

Gene expression changes in asthma and atopy group were quantitatively analyzed by real time PCR and genomic biomarkers were analyzed by DNA chip analysis.

(A) Asthma results

(B) Atopic dermatitis results

Example  6: for gene expression analysis DNA chip Production

Using a MicroGrid spotter manufactured by BioRobotics, a glass slide for microscope prepared in the above reagent, apparatus and equipment section was divided into four sections in the microarray device, and each gene spotted at 50 pmol / μl concentration was spotted in each section.

The glass slide was incubated for 2 hours at 80 ° C for 4 hours and incubated at 42 ° C for 45 min with blocking buffer (5X SSC, 1% BSA, 0.1% SDS) . isopropanol, shaking incubation for 1 min, discarding, and shaking incubation for 5 min with distilled water for 5 min. After drying at room temperature, it was stored in sealed box. (Fig. 2)

Apogent Discovery's human EZ-rays oligo library was used to select probes for genes associated with selected asthma and atopy disorders.

FIG. 1 shows a scatter plot and clustering analysis of gene expression in asthmatic patients by the K-means algorithm.

2 shows an example of the production of a DNA chip in which 79 kinds of genes related to asthma and allergy are spotted on a glass slide and a chamber is attached so that four specimens can be applied.

FIGS. 3A to 3F show results of real-time gene amplification of genomic biomarkers derived from analysis of gene expression in asthma and allergic diseases using DENE chip.

<110> KOREA UNIVERSITY <120> Genetic biomarkers and DNA chip for analysing for asthma and          atopy diseases <130> GNP-P08-117 <160> 148 <170> Kopatentin 2.0 <210> 1 <211> 1485 <212> DNA <213> Homo sapiens <400> 1 tcagccaatt agagctccag ttgtcactcc tacccacact gggcctgggg gtgaagggaa 60 gtgtttatta ggggtacatg tgaagccgtc cagaagtgtc agagtctttg tagctttgaa 120 agtcacctag gttatttggg catgctctcc tgagtcctct gctagttaag ctctctgaaa 180 agaaggtggc agacccggtt tgctgatcgc cccagggatc aggaggctga tcccaaagtt 240 gtcagatgga gagtaaatac aaggagatac tcttgctaac aggcctggat aacatcactg 300 atgaggaact ggataggttt aagttctttc tttcagacga gtttaatatt gccacaggca 360 aactacatac tgcaaacaga atacaagtag ctaccttgat gattcaaaat gctggggcgg 420 tgtctgcagt gatgaagacc attcgtattt ttcagaagtt gaattatatg cttttggcaa 480 aacgtcttca ggaggagaag gagaaagttg ataagcaata caaatcggta acaaaaccaa 540 agccactaag tcaagctgaa atgagtcctg ctgcatctgc agccatcaga aatgatgtcg 600 caaagcaacg tgctgcacca aaagtctctc ctcatgttaa gcctgaacag aaacagatgg 660 tggcccagca ggaatctatc agagaagggt ttcagaagcg ctgtttgcca gttatggtac 720 tgaaagcaaa gaagcccttc acgtttgaga cccaagaagg caagcaggag atgtttcatg 780 ctacagtggc tacagaaaag gaattcttct ttgtaaaagt ttttaataca ctgctgaaag 840 ataaattcat tccaaagaga ataattataa tagcaagata ttatcggcac agtggtttct 900 tagaggtaaa tagcgcctca cgtgtgttag atgctgaatc tgaccaaaag gttaatgtcc 960 cgctgaacat tatcagaaaa gctggtgaaa ccccgaagat caacacgctt caaactcagc 1020 cccttggaac aattgtgaat ggtttgtttg tagtccagaa ggtaacagaa aagaagaaaa 1080 acatattatt tgacctaagt gacaacactg ggaaaatgga agtactgggg gttagaaacg 1140 aggacacaat gaaatgtaag gaaggagata aggttcgact tacattcttc acactgtcaa 1200 aaaatggaga aaaactacag ctgacatctg gagttcatag caccataaag gttattaagg 1260 ccaaaaaaaa aacatagaga agtaaaaagg accaattcaa gccaactggt ctaagcagca 1320 tttaattgaa gaatatgtga tacagcctct tcaatcagat tgtaagttac ctgaaagctg 1380 cagttcacag gctcctctct ccaccaaatt aggatagaat aattgctgga taaacaaatt 1440 cagaatatca acagatgatc acaataaaca tctgtttctc attcc 1485 <210> 2 <211> 2714 <212> DNA <213> Homo sapiens <400> 2 aatcttatga acagaaccag gacagggagg ctggccggag gttcctgcag agggagcgtc 60 aaggccctgt gctgctgtcc ctgggggcca gaggggttgc ccagcatgcc cactggcagg 120 agagagggaa ctgacccact tgctcctacc agcttctgaa ggctccaaag tccggaggtg 180 cagaaagcca ggaccaagag acaggcagct caccagggtg gacaaatcgc cagagatgtg 240 gtgcattgtc ctgttttcac ttttggcatg ggtttatgct gagcctacca tgtatgggga 300 gatcctgtcc cctaactatc ctcaggcata tcccagtgag gtagagaaat cttgggacat 360 agaagttcct gaagggtatg ggattcacct ctacttcacc catctggaca ttgagctgtc 420 agagaactgt gcgtatgact cagtgcagat aatctcagga gacactgaag aagggaggct 480 ctgtggacag aggagcagta acaatcccca ctctccaatt gtggaagagt tccaagtccc 540 atacaacaaa ctccaggtga tctttaagtc agacttttcc aatgaagagc gttttacggg 600 gtttgctgca tactatgttg ccacagacat aaatgaatgc acagattttg tagatgtccc 660 ttgtagccac ttctgcaaca atttcattgg tggttacttc tgctcctgcc ccccggaata 720 tttcctccat gatgacatga agaattgcgg agttaattgc agtggggatg tattcactgc 780 actgattggg gagattgcaa gtcccaatta tcccaaacca tatccagaga actcaaggtg 840 tgaataccag atccggttgg agaaagggtt ccaagtggtg gtgaccttgc ggagagaaga 900 ttttgatgtg gaagcagctg actcagcggg aaactgcctt gacagtttag tttttgttgc 960 aggagatcgg caatttggtc cttactgtgg tcatggattc cctgggcctc taaatattga 1020 aaccaagagt aatgctcttg atatcatctt ccaaactgat ctaacagggc aaaaaaaggg 1080 ctggaaactt cgctatcatg gagatccaat gccctgccct aaggaagaca ctcccaattc 1140 tgtttgggag cctgcgaagg caaaatatgt ctttagagat gtggtgcaga taacctgtct 1200 ggatgggttt gaagttgtgg agggacgtgt tggtgcaaca tctttctatt cgacttgtca 1260 aagcaatgga aagtggagta attccaaact gaaatgtcaa cctgtggact gtggcattcc 1320 tgaatccatt gagaatggta aagttgaaga cccagagagc actttgtttg gttctgtcat 1380 ccgctacact tgtgaggagc catattacta catggaaaat ggaggaggtg gggagtatca 1440 ctgtgctggt aacgggagct gggtgaatga ggtgctgggc ccggagctgc cgaaatgtgt 1500 tccagtctgt ggagtcccca gagaaccctt tgaagaaaaa cagaggataa ttggaggatc 1560 cgatgcagat attaaaaact tcccctggca agtcttcttt gacaacccat gggctggtgg 1620 agcgctcatt aatgagtact gggtgctgac ggctgctcat gttgtggagg gaaacaggga 1680 gccaacaatg tatgttgggt ccacctcagt gcagacctca cggctggcaa aatccaagat 1740 gctcactcct gagcatgtgt ttattcatcc gggatggaag ctgctggaag tcccagaagg 1800 acgaaccaat tttgataatg acattgcact ggtgcggctg aaagacccag tgaaaatggg 1860 acccaccgtc tctcccatct gcctaccagg cacctcttcc gactacaacc tcatggatgg 1920 ggacctggga ctgatctcag gctggggccg aacagagaag agagatcgtg ctgttcgcct 1980 caaggcggca aggttacctg tagctccttt aagaaaatgc aaagaagtga aagtggagaa 2040 acccacagca gatgcagagg cctatgtttt cactcctaac atgatctgtg ctggaggaga 2100 gaagggcatg gatagctgta aaggggacag tggtggggcc tttgctgtac aggatcccaa 2160 tgacaagacc aaattctacg cagctggcct ggtgtcctgg gggccccagt gtgggaccta 2220 tgggctctac acacgggtaa agaactatgt tgactggata atgaagacta tgcaggaaaa 2280 tagcaccccc cgtgaggact aatccagata catcccacca gcctctccaa gggtggtgac 2340 caatgcatta ccttctgttc cttatgatat tctcattatt tcatatgac tgaaagaaga 2400 cacgagcgaa tgatttaaat agaacttgat tgttgagacg ccttgctaga ggtagagttt 2460 gatcatagaa ttgtgctggt catacatttg tggtctgact ccttggggtc ctttccccgg 2520 agtacctatt gtagataaca ctatgggtgg ggcactcctt tcttgcacta ttccacaggg 2580 ataccttaat tctttgtttc ctctttacct gttcaaaatt ccatttactt gatcattctc 2640 agtatccact gtctatgtac aataaaggat gtttataagc aaaaaaaaaaaaaaaaaaa 2700 aaaaaaaaaa aaaa 2714 <210> 3 <211> 2609 <212> DNA <213> Homo sapiens <400> 3 ggctctctac ctctcgccgc ccctagggag gacaccatgg gcccactgat ggttcttttt 60 tgcctgctgt tcctgtaccc aggtctggca gactcggctc cctcctgccc tcagaacgtg 120 cctctcgc tactcctgcc cccagggcct gtacccatcc ccagcatcac ggctgtgcaa gagcagcgga 240 cagtggcaga ccccaggagc cacccggtct ctgtctaagg cggtctgcaa acctgtgcgc 300 tgtccagccc ctgtctcctt tgagaatggc atttataccc cacggctggg gtcctatccc 360 gtgggtggca atgtgagctt cgagtgtgag gatggcttca tattgcgggg ctcgcctgtg 420 cgtcagtgtc gccccaacgg catgtgggat ggagaaacag ctgtgtgtga taatggggct 480 ggccactgcc ccaacccagg catttcactg ggcgcagtgc ggacaggctt ccgctttggt 540 catggggaca aggtccgcta tcgctgctcc tcgaatcttg tgctcacggg gtcttcggag 600 cgggagtgcc agggcaacgg ggtctggagt ggaacggagc ccatctgccg ccaaccctac 660 tcttatgact tccctgagga cgtggcccct gccctgggca cttccttctc ccacatgctt 720 ggggccacca atcccaccca gaagacaaag gaaagcctgg gccgtaaaat ccaaatccag 780 cgctctggtc atctgaacct ctacctgctc ctggactgtt cgcagagtgt gtcggaaaat 840 gactttctca tcttcaagga gagcgcctcc ctcatggtgg acaggatctt cagctttgag 900 atcaatgtga gcgttgccat tatcaccttt gcctcagagc ccaaagtcct catgtctgtc 960 ctgaacgaca actcccggga tatgactgag gtgatcagca gcctggaaaa tgccaactat 1020 aaagatcatg aaaatggaac tgggactaac acctatgcag ccttaaacag tgtctatctc 1080 atgatgaaca accaaatgcg actcctcggc atggaaacga tggcctggca ggaaatccga 1140 catgccatca tccttctgac agatggaaag tccaatatgg gtggctctcc caagacagct 1200 gttgaccata tcagagagat cctgaacatc aaccagaaga ggaatgacta tctggacatc 1260 tatgccatcg gggtgggcaa gctggatgtg gactggagag aactgaatga gctagggtcc 1320 aagaaggatg gtgagaggca tgccttcatt ctgcaggaca caaaggctct gcaccaggtc 1380 tttgaacata tgctggatgt ctccaagctc acagacacca tctgcggggt ggggaacatg 1440 tcagcaaacg cctctgacca ggagaggaca ccctggcatg tcactattaa gcccaagagc 1500 caagagacct gccggggggc cctcatctcc gaccaatggg tcctgacagc agctcattgc 1560 ttccgcgatg gcaacgacca ctccctgtgg agggtcaatg tgggagaccc caaatcccag 1620 tggggcaaag aattccttat tgagaaggcg gtgatctccc cagggtttga tgtctttgcc 1680 aaaaagaacc agggaatcct ggagttctat ggtgatgaca tagctctgct gaagctggcc 1740 cagaaagtaa agatgtccac ccatgccagg cccatctgcc ttccctgcac gatggaggcc 1800 aatctggctc tgcggagacc tcaaggcagc acctgtaggg accatgagaa tgaactgctg 1860 aacaaacaga gtgttcctgc tcattttgtc gccttgaatg ggagcaaact gaacattaac 1920 cttaagatgg gagtggagtg gacaagctgt gccgaggttg tctcccaaga aaaaaccatg 1980 ttccccaact tgacagatgt cagggaggtg gtgacagacc agttcctatg cagtgggacc 2040 caggaggatg agagtccctg caagggagaa tctgggggag cagttttcct tgagcggaga 2100 ttcaggtttt ttcaggtggg tctggtgagc tggggtcttt acaacccctg ccttggctct 2160 gctgacaaaa actcccgcaa aagggcccct cgtagcaagg tcccgccgcc acgagacttt 2220 cacatcaatc tcttccgcat gcagccctgg ctgaggcagc acctggggga tgtcctgaat 2280 tttttacccc tctagccatg gccactgagc cctctgctgc cctgccagaa tctgccgccc 2340 ctccatcttc tacctctgaa tggccaccct tagaccctgt gatccatcct ctctcctagc 2400 tgagtaaatc cgggtctcta ggatgccaga ggcagcgcac acaagctggg aaatcctcag 2460 ggctcctacc agcaggactg cctcgctgcc ccacctcccg ctccttggcc tgtccccaga 2520 ttccttccct ggttgacttg actcatgctt gtttcacttt cacatggaat ttcccagtta 2580 tgaaattaat aaaaatcaat ggtttccac 2609 <210> 4 <211> 5101 <212> DNA <213> Homo sapiens <400> 4 cactcctccc catcctctcc ctctgtccct ctgtccctct gaccctgcac tgtcccagca 60 ccatgggacc cacctcaggt cccagcctgc tgctcctgct actaacccac ctccccctgg 120 ctctggggag tcccatgtac tctatcatca cccccaacat cttgcggctg gagagcgagg 180 agaccatggt gctggaggcc cacgacgcgc aaggggatgt tccagtcact gttactgtcc 240 acgacttccc aggcaaaaaa ctagtgctgt ccagtgagaa gactgtgctg acccctgcca 300 ccaaccacat gggcaacgtc accttcacga tcccagccaa cagggagttc aagtcagaaa 360 aggggcgcaa caagttcgtg accgtgcagg ccaccttcgg gacccaagtg gtggagaagg 420 tggtgctggt cagcctgcag agcgggtacc tcttcatcca gacagacaag accatctaca 480 cccctggctc cacagttctc tatcggatct tcaccgtcaa ccacaagctg ctacccgtgg 540 gccggacggt catggtcaac attgagaacc cggaaggcat cccggtcaag caggactcct 600 tgtcttctca gaaccagctt ggcgtcttgc ccttgtcttg ggacattccg gaactcgtca 660 acatgggcca gtggaagatc cgagcctact atgaaaactc accacagcag gtcttctcca 720 ctgagtttga ggtgaaggag tacgtgctgc ccagtttcga ggtcatagtg gagcctacag 780 agaaattcta ctacatctat aacgagaagg gcctggaggt caccatcacc gccaggttcc 840 tctacgggaa gaaagtggag ggaactgcct ttgtcatctt cgggatccag gatggcgaac 900 agaggatttc cctgcctgaa tccctcaagc gcattccgat tgaggatggc tcgggggagg 960 ttgtgctgag ccggaaggta ctgctggacg gggtgcagaa cccccgagca gaagacctgg 1020 tggggaagtc tttgtacgtg tctgccaccg tcatcttgca ctcaggcagt gacatggtgc 1080 aggcagagcg cagcgggatc cccatcgtga cctctcccta ccagatccac ttcaccaaga 1140 cacccaagta cttcaaacca ggaatgccct ttgacctcat ggtgttcgtg acgaaccctg 1200 atggctctcc agcctaccga gtccccgtgg cagtccaggg cgaggacact gtgcagtctc 1260 taacccaggg agatggcgtg gccaaactca gcatcaacac acaccccagc cagaagccct 1320 tgagcatcac ggtgcgcacg aagaagcagg agctctcgga ggcagagcag gctaccagga 1380 ccatgcaggc tctgccctac agcaccgtgg gcaactccaa caattacctg catctctcag 1440 tgctacgtac agagctcaga cccggggaga ccctcaacgt caacttcctc ctgcgaatgg 1500 accgcgccca cgaggccaag atccgctact acacctacct gatcatgaac aagggcaggc 1560 tgttgaaggc gggacgccag gtgcgagagc ccggccagga cctggtggtg ctgcccctgt 1620 ccatcaccac cgacttcatc ccttccttcc gcctggtggc gtactacacg ctgatcggtg 1680 ccagcggcca gagggaggtg gtggccgact ccgtgtgggt ggacgtcaag gactcctgcg 1740 tgggctcgct ggtggtaaaa agcggccagt cagaagaccg gcagcctgta cctgggcagc 1800 agatgaccct gaagatagag ggtgaccacg gggcccgggt ggtactggtg gccgtggaca 1860 agggcgtgtt cgtgctgaat aagaagaaca aactgacgca gagtaagatc tgggacgtgg 1920 tggagaaggc agacatcggc tgcaccccgg gcagtgggaa ggattacgcc ggtgtcttct 1980 ccgacgcagg gctgaccttc acgagcagca gtggccagca gaccgcccag agggcagaac 2040 ttcagtgccc gcagccagcc gcccgccgac gccgttccgt gcagctcacg gagaagcgaa 2100 tggacaaagt cggcaagtac cccaaggagc tgcgcaagtg ctgcgaggac ggcatgcggg 2160 agaaccccat gaggttctcg tgccagcgcc ggacccgttt catctccctg ggcgaggcgt 2220 gcaagaaggt cttcctggac tgctgcaact acatcacaga gctgcggcgg cagcacgcgc 2280 gggccagcca cctgggcctg gccaggagta acctggatga ggacatcatt gcagaagaga 2340 acatcgtttc ccgaagtgag ttcccagaga gctggctgtg gaacgttgag gacttgaaag 2400 agccaccgaa aaatggaatc tctacgaagc tcatgaatat atttttgaaa gactccatca 2460 ccacgtggga gattctggct gtgagcatgt cggacaagaa agggatctgt gtggcagacc 2520 ccttcgaggt cacagtaatg caggacttct tcatcgacct gcggctaccc tactctgttg 2580 ttcgaaacga gcaggtggaa atccgagccg ttctctacaa ttaccggcag aaccaagagc 2640 tcaaggtgag ggtggaacta ctccacaatc cagccttctg cagcctggcc accaccaaga 2700 ggcgtcacca gcagaccgta accatccccc ccaagtcctc gttgtccgtt ccatatgtca 2760 tcgtgccgct aaagaccggc ctgcaggaag tggaagtcaa ggctgctgtc taccatcatt 2820 tcatcagtga cggtgtcagg aagtccctga aggtcgtgcc ggaaggaatc agaatgaaca 2880 aaactgtggc tgttcgcacc ctggatccag aacgcctggg ccgtgaagga gtgcagaaag 2940 aggacatccc acctgcagac ctcagtgacc aagtcccgga caccgagtct gagaccagaa 3000 ttctcctgca agggacccca gtggcccaga tgacagagga tgccgtcgac gcggaacggc 3060 tgaagcacct cattgtgacc ccctcgggct gcggggaaca gaacatgatc ggcatgacgc 3120 ccacggtcat cgctgtgcat tacctggatg aaacggagca gtgggagaag ttcggcctag 3180 agaagcggca gggggccttg gagctcatca agaaggggta cacccagcag ctggccttca 3240 gacaacccag ctctgccttt gcggccttcg tgaaacgggc acccagcacc tggctgaccg 3300 cctacgtggt caaggtcttc tctctggctg tcaacctcat cgccatcgac tcccaagtcc 3360 tctgcggggc tgttaaatgg ctgatcctgg agaagcagaa gcccgacggg gtcttccagg 3420 aggatgcgcc cgtgatacac caagaaatga ttggtggatt acggaacaac aacgagaaag 3480 acatggccct cacggccttt gttctcatct cgctgcagga ggctaaagat atttgcgagg 3540 agcaggtcaa cagcctgcca ggcagcatca ctaaagcagg agacttcctt gaagccaact 3600 acatgaacct acagagatcc tacactgtgg ccattgctgg ctatgctctg gcccagatgg 3660 gcaggctgaa ggggcctctt cttaacaaat ttctgaccac agccaaagat aagaaccgct 3720 gggaggaccc tggtaagcag ctctacaacg tggaggccac atcctatgcc ctcttggccc 3780 tactgcagct aaaagacttt gactttgtgc ctcccgtcgt gcgttggctc aatgaacaga 3840 gatactacgg tggtggctat ggctctaccc aggccacctt catggtgttc caagccttgg 3900 ctcaatacca aaaggacgcc cctgaccacc aggaactgaa ccttgatgtg tccctccaac 3960 tgcccagccg cagctccaag atcacccacc gtatccactg ggaatctgcc agcctcctgc 4020 gatcagaaga gaccaaggaa aatgagggtt tcacagtcac agctgaagga aaaggccaag 4080 gcaccttgtc ggtggtgaca atgtaccatg ctaaggccaa agatcaactc acctgtaata 4140 aattcgacct caaggtcacc ataaaaccag caccggaaac agaaaagagg cctcaggatg 4200 ccaagaacac tatgatcctt gagatctgta ccaggtaccg gggagaccag gatgccacta 4260 tgtctatatt ggacatatcc atgatgactg gctttgctcc agacacagat gacctgaagc 4320 agctggccaa tggtgttgac agatacatct ccaagtatga gctggacaaa gccttctccg 4380 ataggaacac cctcatcatc tacctggaca aggtctcaca ctctgaggat gactgtctag 4440 ctttcaaagt tcaccaatac tttaatgtag agcttatcca gcctggagca gtcaaggtct 4500 acgcctatta caacctggag gaaagctgta cccggttcta ccatccggaa aaggaggatg 4560 gaaagctgaa caagctctgc cgtgatgaac tgtgccgctg tgctgaggag aattgcttca 4620 tacaaaagtc ggatgacaag gtcaccctgg aagaacggct ggacaaggcc tgtgagccag 4680 gagtggacta tgtgtacaag acccgactgg tcaaggttca gctgtccaat gactttgacg 4740 agtacatcat ggccattgag cagaccatca agtcaggctc ggatgaggtg caggttggac 4800 agcagcgcac gttcatcagc cccatcaagt gcagagaagc cctgaagctg gaggagaaga 4860 aacactacct catgtggggt ctctcctccg atttctgggg agagaagccc aacctcagct 4920 acatcatcgg gaaggacact tgggtggagc actggcccga ggaggacgaa tgccaagacg 4980 aagagaacca gaaacaatgc caggacctcg gcgccttcac cgagagcatg gttgtctttg 5040 ggtgccccaa ctgaccacac ccccattccc ccactccaga taaagcttca gttatatctc 5100 a 5101 <210> 5 <211> 3976 <212> DNA <213> Homo sapiens <400> 5 ctgggtcctg tgtgtgccac aggggtgggg tgtccagcga gcggtctcct cctcctgcta 60 gtgctgctgc ggcgtcccgc ggcctccccg agtcgggcgg gaggggagag cgggtgtgga 120 tttgtcttga cggtaattgt tgcgtttcca cgtctcggag gcctgcgcgc tgggttgctc 180 cttcttcggg agcgagctgt tctcagcgat cccactccca gccggggctc cccacacaca 240 ctgggctgcg tgcgtgtgga gtgggacccg cgcacacgcg tgtctctgga cagctacggc 300 gccgaaagaa ctaaaattcc agatggcaaa ctcaatgaat ggcagaaacc ctggtggtcg 360 aggaggaaat ccccgaaaag gtcgaatttt gggtattatt gatgctattc aggatgcagt 420 tggaccccct aagcaagctg ccgcagatcg caggaccgtg gagaagactt ggaagctcat 480 ggacaaagtg gtaagactgt gccaaaatcc caaacttcag ttgaaaaata gcccaccata 540 tatacttgat attttgcctg atacatatca gcatttacga cttatattga gtaaatatga 600 tgacaaccag aaacttgccc aactcagtga gaatgagtac tttaaaatct acattgatag 660 ccttatgaaa aagtcaaaac gggcaataag actctttaaa gaaggcaagg agagaatgta 720 tgaagaacag tcacaggaca gacgaaatct cacaaaactg tcccttatct tcagtcacat 780 gctggcagaa atcaaagcaa tctttcccaa tggtcaattc cagggagata actttcgtat 840 cacaaaagca gatgctgctg aattctggag aaagtttttt ggagacaaaa ctatcgtacc 900 atggaaagta ttcagacagt gccttcatga ggtccaccag attagctctg gcctggaagc 960 aatggctcta aaatcaacaa ttgatttaac ttgcaatgat tacatttcag tttttgaatt 1020 tgatattttt accaggctgt ttcagccttg gggctctatt ttgcggaatt ggaatttctt 1080 agctgtgaca catccaggtt acatggcatt tctcacatat gatgaagtta aagcacgact 1140 acagaaatat agcaccaaac ccggaagcta tattttccgg ttaagttgca ctcgattggg 1200 acagtgggcc attggctatg tgactgggga tgggaatatc ttacagacca tacctcataa 1260 caagccctta tttcaagccc tgattgatgg cagcagggaa ggattttatc tttatcctga 1320 tgggaggagt tataatcctg atttaactgg attatgtgaa cctacacctc atgaccatat 1380 aaaagttaca caggaacaat atgaattata ttgtgaaatg ggctccactt ttcagctctg 1440 taagatttgt gcagagaatg acaaagatgt caagattgag ccttgtgggc atttgatgtg 1500 cacctcttgc cttacggcat ggcaggagtc ggatggtcag ggctgccctt tctgtcgttg 1560 tgaaataaaa ggaactgagc ccataatcgt ggaccccttt gatccaagag atgaaggctc 1620 caggtgttgc agcatcattg acccctttgg catgccgatg ctagacttgg acgacgatga 1680 tgatcgtgag gagtccttga tgatgaatcg gttggcaaac gtccgaaagt gcactgacag 1740 gcagaactca ccagtcacat caccaggatc ctctcccctt gcccagagaa gaaagccaca 1800 gcctgaccca ctccagatcc cacatctaag cctgccaccc gtgcctcctc gcctggatct 1860 aattcagaaa ggcatagtta gatctccctg tggcagccca acgggttcac caaagtcttc 1920 tccttgcatg gtgagaaaac aagataaacc actcccagca ccacctcctc ccttaagaga 1980 tcctcctcca ccgccacctg aaagacctcc accaatccca ccagacaata gactgagtag 2040 acacatccat catgtggaaa gcgtgccttc cagagacccg ccaatgcctc ttgaagcatg 2100 gtgccctcgg gatgtgtttg ggactaatca gcttgtggga tgtcgactcc taggggaggg 2160 ctctccaaaa cctggaatca cagcgagttc aaatgtcaat ggaaggcaca gtagagtggg 2220 ctctgaccca gtgcttatgc ggaaacacag acgccatgat ttgcctttag aaggagctaa 2280 ggtcttttcc aatggtcacc ttggaagtga agaatatgat gttcctcccc ggctttctcc 2340 tcctcctcca gttaccaccc tcctccctag cataaagtgt actggtccgt tagcaaattc 2400 tctttcagag aaaacaagag acccagtaga ggaagatgat gatgaataca agattccttc 2460 atcccaccct gtttccctga attcacaacc atctcattgt cataatgtaa aacctcctgt 2520 tcggtcttgt gataatggtc actgtatgct gaatggaaca catggtccat cttcagagaa 2580 gaaatcaaac atccctgact taagcatata tttaaaggga gatgtttttg attcagcctc 2640 tgatcccgtg ccattaccac ctgccaggcc tccaactcgg gacaatccaa agcatggttc 2700 ttcactcaac aggacgccct ctgattatga tcttctcatc cctccattag gtgaagatgc 2760 ttttgatgcc ctccctccat ctctcccacc tcccccacct cctgcaaggc atagtctcat 2820 tgaacattca aaacctcctg gctccagtag ccggccatcc tcaggacagg atctttttct 2880 tcttccttca gatccctttg ttgatctagc aagtggccaa gttcctttgc ctcctgctag 2940 aaggttacca ggtgaaaatg tcaaaactaa cagaacatca caggactatg atcagcttcc 3000 ttcatgttca gatggttcac aggcaccagc cagaccccct aaaccacgac cgcgcaggac 3060 tgcaccagaa attcaccaca gaaaacccca tgggcctgag gcggcattgg aaaatgtcga 3120 tgcaaaaatt gcaaaactca tgggagaggg ttatgccttt gaagaggtga agagagcctt 3180 agagatagcc cagaataatg tcgaagttgc ccggagcatc ctccgagaat ttgccttccc 3240 tcctccagta tccccacgtc taaatctata gcagccagaa ctgtagacac caaaatggaa 3300 agcaatcgat gtattccaag agtgtggaaa taaagagaac tgagatggaa ttcaagagag 3360 aagtgtctcc tcctcgtgta gcagcttgag aagaggcttg ggagtgcagc ttctcaaagg 3420 agaccgatgc ttgctcagga tgtcgacagc tgtggcttcc ttgtttttgc tagccatatt 3480 tttaaatcag ggttgaactg acaaaaataa tttaaagacg tttacttccc ttgaactttg 3540 aacctgtgaa atgctttacc ttgtttacag tttggcaaag ttgcagtttg ttcttgtttt 3600 tagtttagtt ttgttttggt gttttgatac ctgtactgtg ttcttcacag accctttgta 3660 gcgtggtcag gtctgctgta acatttccca ccaactctct tgctgtccac atcaacagct 3720 aaatcattta ttcatatgga tctctaccat ccccatgcct tgcccaggtc cagttccatt 3780 tctctcattc acaagatgct ttgaaggttc tgattttcaa ctgatcaaac taatgcaaaa 3840 aaaaaaaagt atgtattctt cactactgag tttcttcttt ggaaaccatc actattgaga 3900 gatgggaaaa acctgaatgt ataaagcatt tatttgtcaa taaactgcct tttgtaaggg 3960 gttttcacat aacata 3976 <210> 6 <211> 793 <212> DNA <213> Homo sapiens <400> 6 aggagttgtg agtttccaag ccccagctca ctctgaccac ttctctgcct gcccagcatc 60 atgaagggcc ttgcagctgc cctccttgtc ctcgtctgca ccatggccct ctgctcctgt 120 gcacaagttg gtaccaacaa agagctctgc tgcctcgtct atacctcctg gcagattcca 180 caaaagttca tagttgacta ttctgaaacc agcccccagt gccccaagcc aggtgtcatc 240 ctcctaacca agagaggccg gcagatctgt gctgacccca ataagaagtg ggtccagaaa 300 tacatcagcg acctgaagct gaatgcctga ggggcctgga agctgcgagg gcccagtgaa 360 cttggtgggc ccaggaggga acaggagcct gagccagggc aatggccctg ccaccctgga 420 ggccacctct tctaagagtc ccatctgcta tgcccagcca cattaactaa ctttaatctt 480 agtttatgca tcatatttca ttttgaaatt gatttctatt gttgagctgc attatgaaat 540 tagtattttc tctgacatct catgacattg tctttatcat cctttcccct ttcccttcaa 600 ctcttcgtac attcaatgca tggatcaatc agtgtgatta gctttctcag cagacattgt 660 gccatatgta tcaaatgaca aatctttatt gaatggtttt gctcagcacc accttttaat 720 atattggcag tacttattat ataaaaggta aaccagcatt ctcactgtga aaaaaaaaaa 780 aaaaaaaaaaaaa 793 <210> 7 <211> 760 <212> DNA <213> Homo sapiens <400> 7 gaggaaccga gaggctgaga ctaacccaga aacatccaat tctcaaactg aagctcgcac 60 tctcgcctcc agcatgaaag tctctgccgc ccttctgtgc ctgctgctca tagcagccac 120 cttcattccc caagggctcg ctcagccaga tgcaatcaat gccccagtca cctgctgtta 180 taacttcacc aataggaaga tctcagtgca gaggctcgcg agctatagaa gaatcaccag 240 cagcaagtgt cccaaagaag ctgtgatctt caagaccatt gtggccaagg agatctgtgc 300 tgaccccaag cagaagtggg ttcaggattc catggaccac ctggacaagc aaacccaaac 360 tccgaagact tgaacactca ctccacaacc caagaatctg cagctaactt attttcccct 420 agctttcccc agacaccctg ttttatttta ttataatgaa ttttgtttgt tgatgtgaaa 480 cattatgcct taagtaatgt taattcttat ttaagttatt gatgttttaa gtttatcttt 540 catggtacta gtgtttttta gatacagaga cttggggaaa ttgcttttcc tcttgaacca 600 cagttctacc cctgggatgt tttgagggtc tttgcaagaa tcattaatac aaagaatttt 660 ttttaacatt ccaatgcatt gctaaaatat tattgtggaa atgaatattt tgtaactatt 720 acaccaaata aatatatttt tgtacaaaaa aaaaaaaaaa 760 <210> 8 <211> 2918 <212> DNA <213> Homo sapiens <400> 8 caggacagag catggatcgc ctacagactg cactcctggt tgtcctcgtc ctccttgctg 60 tggcgcttca agcaactgag gcaggcccct acggcgccaa catggaagac agcgtctgct 120 gccgtgatta cgtccgttac cgtctgcccc tgcgcgtggt gaaacacttc tactggacct 180 cagactcctg cccgaggcct ggcgtggtgt tgctaacctt cagggataag gagatctgtg 240 ccgatcccag agtgccctgg gtgaagatga ttctcaataa gctgagccaa tgaagagcct 300 actctgatga ccgtggcctt ggctcctcca ggaaggctca ggagccctac ctccctgcca 360 ttatagctgc tccccgccag aagcctgtgc caactctctg cattccctga tctccatccc 420 tgtggctgtc acccttggtc acctccgtgc tgtcactgcc atctcccccc tgacccctct 480 aacccatcct ctgcctccct ccctgcagtc agagggtcct gttcccatca gcgattcccc 540 tgcttaaacc cttccatgac tccccactgc cctaagctga ggtcagtctc ccaagcctgg 600 catgtggccc tctggatctg ggttccatct ctgtctccag cctgcccact tcccttcatg 660 aatgttgggt tctagctccc tgttctccaa acccatacta cacatcccac ttctgggtct 720 ttgcctggga tgttgctgac acccagaaag tcccaccacc tgcacatgtg tagccccacc 780 agccctccaa ggcattgctc gcccaagcag ctggtaattc catttcatgt attagatgtc 840 ccctggccct ctgtcccctc ttaataaccc tagtcacagt ctccgcagat tcttgggatt 900 tgggggtttt ctcccccacc tctccactag ttggaccaag gtttctagct aagttactct 960 agtctccaag cctctagcat agagcactgc agacaggccc tggctcagaa tcagagccca 1020 gaaagtggct gcagacaaaa tcaataaaac taatgtccct cccctctccc tgccaaaagg 1080 cagttacata tcaatacaga gactcaaggt cactagaaat gggccagctg ggtcaatgtg 1140 aagccccaaa tttgcccaga ttcacctttc ttcccccact cccttttttt tttttttttt 1200 gagatggagt ttcgctcttg tcacccacgc tggagtgcaa tggtgtggtc ttggcttatt 1260 gaagcctctg cctcctgggt tcaagtgatt ctcttgcctc agcctcctga gtagctggga 1320 ttacaggttc ctgctaccac gcccagctaa tttttgtatt tttagtagag acgaggcttc 1380 accatgttgg ccaggctggt ctcgaactcc tgtcctcagg taatccgccc acctcagcct 1440 cccaaagtgc tgggattaca ggcgtgagcc acagtgcctg gcctcttccc tctccccacc 1500 ccccccccaa cttttttttt tttttatggc agggtctcac tctgtcgccc aggctggagt 1560 gcagtggcgt gatctcggct cactacaacc tcgacctcct gggttcaagc gattctccca 1620 ccccagcctc ccaagtagct gggattacag gtgtgtgcca ctacggctgg ctaatttttg 1680 tatttttagt agagacaggt ttcaccatat tggccaggct ggtcttgaac tcctgacctc 1740 aagtgatcca ccttccttgt gctcccaaag tgctgagatt acaggcgtga gctatcacac 1800 ccagcctccc cctttttttc ctaataggag actcctgtac ctttcttcgt tttacctatg 1860 tgtcgtgtct gcttacattt ccttctcccc tcaggctttt tttgggtggt cctccaacct 1920 ccaataccca ggcctggcct cttcagagta ccccccattc cactttccct gcctccttcc 1980 ttaaatagct gacaatcaaa ttcatgctat ggtgtgaaag actacctttg acttggtatt 2040 ataagctgga gttatatatg tatttgaaaa cagagtaaat acttaagagg ccaaatagat 2100 gaatggaaga attttaggaa ctgtgagagg gggacaaggt ggagctttcc tggccctggg 2160 aggaagctgg ctgtggtagc gtagcgctct ctctctctgt ctgtggcagg aggcaaagag 2220 tagggtgtaa ttgagtgaag gaatcctggg tagagaccat tctcaggtgg ttgggccagg 2280 ctaaagactg ggatttgggt ctatctatgc ctttctggct gatttttgta gagacggggt 2340 tttgccatgt tacccaggct ggtctcaaac tcctgggctc aagcgatcct cctggctcag 2400 cctcccaaag tgctgggatt acaggcgtga gtcactgcgc ctggcttcct cttcctcttg 2460 agaaatattc ttttcataca gcaagtatgg gacagcagtg tcccaggtaa aggacataaa 2520 tgttacaagt gtctggtcct ttctgaggga ggctggtgcc gctctgcagg gtatttgaac 2580 ctgtggaatt ggaggaggcc atttcactcc ctgaacccag cctgacaaat cacagtgaga 2640 atgttcacct tataggcttg ctgtggggct caggttgaaa gtgtggggag tgacactgcc 2700 taggcatcca gctcagtgtc atccagggcc tgtgtccctc ccgaacccag ggtcaacctg 2760 cctaccacag gcactagaag gacgaatctg cctactgccc atgaacgggg ccctcaagcg 2820 tcctgggatc tccttctccc tcctgtcctg tccttgcccc tcaggactgc tggaaaataa 2880 atcctttaaa atagaaaaaa aaaaaaaaaa aaaaaaaa 2918 <210> 9 <211> 1616 <212> DNA <213> Homo sapiens <400> 9 gccaaggctg gggcagggga gtcagcagag gcctcgctcg ggcgcccagt ggtcctgccg 60 cctggtctca cctcgctatg gttcgtctgc ctctgcagtg cgtcctctgg ggctgcttgc 120 tgaccgctgt ccatccagaa ccacccactg catgcagaga aaaacagtac ctaataaaca 180 gtcagtgctg ttctttgtgc cagccaggac agaaactggt gagtgactgc acagagttca 240 ctgaaacgga atgccttcct tgcggtgaaa gcgaattcct agacacctgg aacagagaga 300 cacactgcca ccagcacaaa tactgcgacc ccaacctagg gcttcgggtc cagcagaagg 360 gcacctcaga aacagacacc atctgcacct gtgaagaagg ctggcactgt acgagtgagg 420 cctgtgagag ctgtgtcctg caccgctcat gctcgcccgg ctttggggtc aagcagattg 480 ctacaggggt ttctgatacc atctgcgagc cctgcccagt cggcttcttc tccaatgtgt 540 catctgcttt cgaaaaatgt cacccttgga caagctgtga gaccaaagac ctggttgtgc 600 aacaggcagg cacaaacaag actgatgttg tctgtggtcc ccaggatcgg ctgagagccc 660 tggtggtgat ccccatcatc ttcgggatcc tgtttgccat cctcttggtg ctggtcttta 720 tcaaaaaggt ggccaagaag ccaaccaata aggcccccca ccccaagcag gaaccccagg 780 agatcaattt tcccgacgat cttcctggct ccaacactgc tgctccagtg caggagactt 840 tacatggatg ccaaccggtc acccaggagg atggcaaaga gagtcgcatc tcagtgcagg 900 agagacytg aggctgcacc cacccaggag tgtggccacg tgggcaaaca ggcagttggc 960 cagagagcct ggtgctgctg ctgctgtggc gtgagggtga ggggctggca ctgactgggc 1020 atagctcccc gcttctgcct gcacccctgc agtttgagac aggagacctg gcactggatg 1080 cagaaacagt tcaccttgaa gaacctctca cttcaccctg gagcccatcc agtctcccaa 1140 cttgtattaa agacagaggc agaagtttgg tggtggtggt gttggggtat ggtttagtaa 1200 tatccaccag accttccgat ccagcagttt ggtgcccaga gaggcatcat ggtggcttcc 1260 ctgcgcccag gaagccatat acacagatgc ccattgcagc attgtttgtg atagtgaaca 1320 actggaagct gcttaactgt ccatcagcag gagactggct aaataaaatt agaatatatt 1380 tatacaca aatctcaaaa acactgttga gtaaggaaaa aaaggcatgc tgctgaatga 1440 tgggtatgga actttttaaa aaagtacatg cttttatgta tgtatattgc ctatggatat 1500 atgatataaat acaatatgca tcatatattg atataacaag ggttctggaa gggtacacag 1560 aaaacccaca gctcgaagag tggtgacgtc tggggtgggg aagaagggtc tggggg 1616 <210> 10 <211> 2757 <212> DNA <213> Homo sapiens <400> 10 gacaagtact gagtgaactc aaaccctctg taaagtaaca gaagttagaa ggggaaatgt 60 cgcctctctg aagattaccc aaagaaaaag tgatttgtca ttgctttata gactgtaaga 120 agagaacatc tcagaagtgg agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga 180 atttttcttc agcaagctgt gaaactaaat ccacaacctt tggagaccca ggaacaccct 240 ccaatctctg tgtgttttgt aaacatcact ggagggtctt ctacgtgagc aattggattg 300 tcatcagccc tgcctgtttt gcacctggga agtgccctgg tcttacttgg gtccaaattg 360 ttggctttca cttttgaccc taagcatctg aagccatggg ccacacacgg aggcagggaa 420 catcaccatc caagtgtcca tacctcaatt tctttcagct cttggtgctg gctggtcttt 480 ctcacttctg ttcaggtgtt atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt 540 cctgtggtca caatgtttct gttgaagagc tggcacaaac tcgcatctac tggcaaaagg 600 agaagaaaat ggtgctgact atgatgtctg gggacatgaa tatatggccc gagtacaaga 660 accggaccat ctttgatatc actaataacc tctccattgt gatcctggct ctgcgcccat 720 ctgacgaggg cacatacgag tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg 780 aacacctggc tgaagtgacg ttatcagtca aagctgactt ccctacacct agtatatctg 840 actttgaaat tccaacttct aatattagaa ggataatttg ctcaacctct ggaggttttc 900 cagagcctca cctctcctgg ttggaaaatg gagaagaatt aaatgccatc aacacaacag 960 tttcccaaga tcctgaaact gagctctatg ctgttagcag caaactggat ttcaatatga 1020 caaccaacca cagcttcatg tgtctcatca agtatggaca tttaagagtg aatcagacct 1080 tcaactggaa tacaaccaag caagagcatt ttcctgataa cctgctccca tcctgggcca 1140 ttaccttaat ctcagtaaat ggaatttttg tgatatgctg cctgacctac tgctttgccc 1200 caagatgcag agagagaagg aggaatgaga gattgagaag ggaaagtgta cgccctgtat 1260 aacagtgtcc gcagaagcaa ggggctgaaa agatctgaag gtcccacctc catttgcaat 1320 tgacctcttc tgggaacttc ctcagatgga caagattacc ccaccttgcc ctttacgtat 1380 ctgctcttag gtgcttcttc acttcagttg ctttgcagga agtgtctaga ggaatatggt 1440 gggcacagaa gtagctctgg tgaccttgat caaggtgttt tgaaatgcag aattcttgag 1500 ttctggaagg gactttagag aataccagtg ttattaatga caaaggcact gaggcccagg 1560 gaggtgaccc gaattataaa ggccagcgcc agaacccaga tttcctaact ctggtgctct 1620 ttccctttat cagtttgact gtggcctgtt aactggtata tacatatata tgtcaggcaa 1680 agtgctgctg gaagtagaat ttgtccaata acaggtcaac ttcagagact atctgatttc 1740 ctaatgtcag agtagaagat tttatgctgc tgtttacaaa agcccaatgt aatgcatagg 1800 aagtatggca tgaacatctt taggagacta atggaaatat tattggtgtt tacccagtat 1860 tccatttttt tcattgtgtt ctctattgct gctctctcac tcccccatga ggtacagcag 1920 aaaggagaac tatccaaaac taatttcctc tgacatgtaa gacgaatgat ttaggtacgt 1980 caaagcagta gtcaaggagg aaagggatag tccaaagact taactggttc atattggact 2040 gataatctct ttaaatggct ttatgctagt ttgacctcat ttgtaaaata tttatgagaa 2100 agttctcatt taaaatgaga tcgttgttta cagtgtatgt actaagcagt aagctatctt 2160 caaatgtcta aggtagtaac tttccatagg gcctccttag atccctaaga tggctttttc 2220 tccttggtat ttctgggtct ttctgacatc agcagagaac tggaaagaca tagccaactg 2280 ctgttcatgt tactcatgac tcctttctct aaaactgcct tccacaattc actagaccag 2340 aagtggacgc aacttaagct gggataatca cattatcatc tgaaaatctg gagttgaaca 2400 gcaaaagaag acaacatttc tcaaatgcac atctcatggc agctaagcca catggctggg 2460 atttaaagcc tttagagcca gcccatggct ttagctacct cactatgctg cttcacaaac 2520 cttgctcctg tgtaaaacta tattctcagt gtagggcaga gaggtctaac accaacataa 2580 ggtactagca gtgtttcccg tattgacagg aatacttaac tcaataattc ttttcttttc 2640 catttagtaa cagttgtgat gactatgttt ctattctaag taattcctgt attctacagc 2700 agatactttg tcagcaatac taagggaaga aacaaagttg aaccgtttct ttaataa 2757 <210> 11 <211> 2574 <212> DNA <213> Homo sapiens <400> 11 ttggatgttc cgggaaagtg atgtgggtag gacaggcggg gcgagccgca ggtgccagaa 60 cacagattgt ataaaaggct gggggctggt ggggagcagg ggaagggaat gtgaccaggt 120 ctaggtctgg agtttcagct tggacactga gccaagcaga caagcaaagc aagccaggac 180 acaccatcct gccccaggcc cagcttctct cctgccttcc aacgccatgg ggagcaatct 240 cagcccccaa ctctgcctga tgccctttat cttgggcctc ttgtctggag gtgtgaccac 300 cactccatgg tctttggccc ggccccaggg atcctgctct ctggaggggg tagagatcaa 360 aggcggctcc ttccgacttc tccaagaggg ccaggcactg gagtacgtgt gtccttctgg 420 cttctacccg taccctgtgc agacacgtac ctgcagatct acggggtcct ggagcaccct 480 gaagactcaa gaccaaaaga ctgtcaggaa ggcagagtgc agagcaatcc actgtccaag 540 accacacgac ttcgagaacg gggaatactg gccccggtct ccctactaca atgtgagtga 600 tgagatctct ttccactgct atgacggtta cactctccgg ggctctgcca atcgcacctg 660 ccaagtgaat ggccgatgga gtgggcagac agcgatctgt gacaacggag cggggtactg 720 ctccaacccg ggcatcccca ttggcacaag gaaggtgggc agccagtacc gccttgaaga 780 cagcgtcacc taccactgca gccgggggct taccctgcgt ggctcccagc ggcgaacgtg 840 tcaggaaggt ggctcttgga gcgggacgga gccttcctgc caagactcct tcatgtacga 900 cacccctcaa gaggtggccg aagctttcct gtcttccctg acagagacca tagaaggagt 960 cgatgctgag gatgggcacg gcccagggga acaacagaag cggaagatcg tcctggaccc 1020 ttcaggctcc atgaacatct acctggtgct agatggatca gacagcattg gggccagcaa 1080 cttcacagga gccaaaaagt gtctagtcaa cttaattgag aaggtggcaa gttatggtgt 1140 gaagccaaga tatggtctag tgacatatgc cacatacccc aaaatttggg tcaaagtgtc 1200 tgaagcagac agcagtaatg cagactgggt cacgaagcag ctcaatgaaa tcaattatga 1260 agaccacaag ttgaagtcag ggactaacac caagaaggcc ctccaggcag tgtacagcat 1320 gatgagctgg ccagatgacg tccctcctga aggctggaac cgcacccgcc atgtcatcat 1380 cctcatgact gatggattgc acaacatggg cggggaccca attactgtca ttgatgagat 1440 ccgggacttg ctatacattg gcaaggatcg caaaaaccca agggaggatt atctggatgt 1500 ctatgtgttt ggggtcgggc ctttggtgaa ccaagtgaac atcaatgctt tggcttccaa 1560 gaaagacaat gagcaacatg tgttcaaagt caaggatatg gaaaacctgg aagatgtttt 1620 ctaccaaatg atcgatgaaa gccagtctct gagtctctgt ggcatggttt gggaacacag 1680 gaagggtacc gattaccaca agcaaccatg gcaggccaag atctcagtca ttcgcccttc 1740 aaagggacac gagagctgta tgggggctgt ggtgtctgag tactttgtgc tgacagcagc 1800 acattgtttc actgtggatg acaaggaaca ctcaatcaag gtcagcgtag gaggggagaa 1860 gcgggacctg gagatagaag tagtcctatt tcaccccaac tacaacatta atgggaaaaa 1920 agaagcagga attcctgaat tttatgacta tgacgttgcc ctgatcaagc tcaagaataa 1980 gctgaaatat ggccagacta tcaggcccat ttgtctcccc tgcaccgagg gaacaactcg 2040 agctttgagg cttcctccaa ctaccacttg ccagcaacaa aaggaagagc tgctccctgc 2100 acaggatatc aaagctctgt ttgtgtctga ggaggagaaa aagctgactc ggaaggaggt 2160 ctacatcaag aatggggata agaaaggcag ctgtgagaga gatgctcaat atgccccagg 2220 ctatgacaaa gtcaaggaca tctcagaggt ggtcacccct cggttccttt gtactggagg 2280 agtgagtccc tatgctgacc ccaatacttg cagaggtgat tctggcggcc ccttgatagt 2340 tcacaagaga agtcgtttca ttcaagttgg tgtaatcagc tggggagtag tggatgtctg 2400 caaaaaccag aagcggcaaa agcaggtacc tgctcacgcc cgagactttc acatcaacct 2460 ctttcaagtg ctgccctggc tgaaggagaa actccaagat gaggatttgg gttttctata 2520 aggggtttcc tgctggacag gggcgtggga ttgaattaaa acagctgcga caac 2574 <210> 12 <211> 1613 <212> DNA <213> Homo sapiens <400> 12 gtagcagttt gtccctgagc tctagcttct ttaaatgaag ctgagtctct gggcaacatc 60 tttagggaga gaggtacaaa aggttcctgg accttctcaa cacagggagc ctgcataatg 120 atgcaagagc agcaacctca aagtacagag aaaagaggct ggttgtccct gagactctgg 180 tctgtggctg ggatttccat tgcactcctc agtgcttgct tcattgtgag ctgtgtagta 240 acttaccatt ttacatatgg tgaaactggc aaaaggctgt ctgaactaca ctcatatcat 300 tcaagtctca cctgcttcag tgaagggaca aaggtgccag cctggggatg ttgcccagct 360 tcttggaagt catttggttc cagttgctac ttcatttcca gtgaagagaa ggtttggtct 420 aagagtgagc agaactgtgt tgagatggga gcacatttgg ttgtgttcaa cacagaagca 480 gagcagaatt tcattgtcca gcagctgaat gagtcatttt cttattttct ggggctttca 540 gacccacaag gtaataataa ttggcaatgg attgataaga caccttatga gaaaaatgtc 600 agattttggc acctaggtga gcccaatcat tctgcagagc aatgtgcttc aatagtcttc 660 tggaaaccta caggatgggg ctggaatgat gttatctgtg aaactagaag gaattcaata 720 tgtgagatga ataagattta cctatgagta gaagcttaat tggaaagaag agaagaatta 780 ctgacgtaat tttttccctg acgtctttaa aattgaaccc tatcatgaaa tgataatttc 840 ttcctgaatt tacacataat ccttatgtta tagaggttca cagaaatgga aagatacctg 900 tttcccttta atcaatcttc tcgtttcctc ttttccatta atgatagaat gcacccttcc 960 tctctttgtt ccattctttc acttgttatt catttttttc tttcttcaca cttcattaca 1020 caaatattta ttgtttcaga gactgtacta ttttgtttgt tagaagattt ataaggcagt 1080 atcttttgaa aattatgact ttccttcctc aatataccat aaagaaatct ttttggtcaa 1140 gatggtagtt ggaactacaa tcatctgaag gcctgacaag agttgaaaga catgttttct 1200 agatggctca ctcacatggc tggcaacttg gtgttggcta ttaatgtaac ctggaaataa 1260 attttattct gcagttaggg atttggcatt ttatatatgt tgattcaatc aagtttggca 1320 agcagggtgt tcgatactgc tatatcctgt attcttggtt tatttgtttt atttctgaga 1380 aatatgtgtt aagatctctc gctgattggg aatttgtcta tttctcattt aaattttgtc 1440 aaatctttct ttgcttgcaa gcatttcttg ttacccaaat ctaacctatt cctgaaaata 1500 tgatggttag caaagtttga gataactaga gcctgtaatc catcatttta aatggcaatg 1560 ataatgacag tttattttta tgttatataa aaacctcaac aaattttcca aac 1613 <210> 13 <211> 1904 <212> DNA <213> Homo sapiens <400> 13 agctatttca aggcgcgcgc ctcgtggtgg actcaccgct agcccgcagc gctcggcttc 60 ctggtaattc ttcacctctt ttctcagctc cctgcagcat gggtgctggg ccctccttgc 120 tgctcgccgc cctcctgctg cttctctccg gcgacggcgc cgtgcgctgc gacacacctg 180 ccaactgcac ctatcttgac ctgctgggca cctgggtctt ccaggtgggc tccagcggtt 240 cccagcgcga tgtcaactgc tcggttatgg gaccacaaga aaaaaaagta gtggtgtacc 300 ttcagaagct ggatacagca tatgatgacc ttggcaattc tggccatttc accatcattt 360 acaaccaagg ctttgagatt gtgttgaatg actacaagtg gtttgccttt tttaagtata 420 aagaagaggg cagcaaggtg accacttact gcaacgagac aatgactggg tgggtgcatg 480 atgtgttggg ccggaactgg gcttgtttca ccggaaagaa ggtgggaact gcctctgaga 540 atgtgtatgt caacacagca caccttaaga attctcagga aaagtattct aataggctct 600 acaagtatga tcacaacttt gtgaaagcta tcaatgccat tcagaagtct tggactgcaa 660 ctacatacat ggaatatgag actcttaccc tgggagatat gattaggaga agtggtggcc 720 acagtcgaaa aatcccaagg cccaaacctg caccactgac tgctgaaata cagcaaaaga 780 ttttgcattt gccaacatct tgggactgga gaaatgttca tggtatcaat tttgtcagtc 840 ctgttcgaaa ccaagcatcc tgtggcagct gctactcatt tgcttctatg ggtatgctag 900 aagcgagaat ccgtatacta accaacaatt ctcagacccc aatcctaagc cctcaggagg 960 ttgtgtcttg tagccagtat gctcaaggct gtgaaggcgg cttcccatac cttattgcag 1020 gaaagtacgc ccaagatttt gggctggtgg aagaagcttg cttcccctac acaggcactg 1080 attctccatg caaaatgaag gaagactgct ttcgttatta ctcctctgag taccactatg 1140 taggaggttt ctatggaggc tgcaatgaag ccctgatgaa gcttgagttg gtccatcatg 1200 ggcccatggc agttgctttt gaagtatatg atgacttcct ccactacaaa aaggggatct 1260 accaccacac tggtctaaga gaccctttca acccctttga gctgactaat catgctgttc 1320 tgcttgtggg ctatggcact gactcagcct ctgggatgga ttactggatt gttaaaaaca 1380 gctggggcac cggctgggt gagaatggct acttccggat ccgcagagga actgatgagt 1440 gtgcaattga gagcatagca gtggcagcca caccaattcc taaattgtag ggtatgcctt 1500 ccagtatttc ataatgatct gcatcagttg taaaggggaa ttggtatatt cacagactgt 1560 agactttcag cagcaatctc agaagcttac aaatagattt ccatgaagat atttgtcttc 1620 agaattaaaa ctgcccttaa ttttaatata cctttcaatc ggccactggc catttttttc 1680 taagtattca attaagtggg aattttctgg aagatggtca gctatgaagt aatagagttt 1740 gcttaatcat ttgtaattca aacatgctat attttttaaa atcaatgtga aaacatagac 1800 ttatttttaa attgtaccaa tcacaagaaa ataatggcaa taattatcaa aacttttaaa 1860 atagatgctc atatttttaa aataaagttt taaaaataac tgca 1904 <210> 14 <211> 2249 <212> DNA <213> Homo sapiens <400> 14 cccggatcgg ggaagtgaaa gtgcctcgga ggaggagggc cggtccggca gtgcagccgc 60 ctcacaggtc ggcggacggg ccaggcgggc ggcctcctga accgaaccga atcggctcct 120 cgggccgtcg tcctcccgcc cctcctcgcc cgccgccgga gttttctttc ggtttcttcc 180 gggcggggg ctccacctcc tcggctttcc ctgcgtccag aggctggcat ggcgcgggcc gagtactgag 300 cgcacggtcg gggcacagca gggccggtgg gtgcagctgg ctcgcgcctc ctctccggcc 360 gccgtctcct ccggtccccg gcgaaagcca ttgagacacc agctggacgt cacgcgccgg 420 agcatgtctg ggagtcagag cgaggtggct ccatccccgc agagtccgcg gagccccgag 480 atgggacggg acttgcggcc cgggtcccgc gtgctcctgc tcctgcttct gctcctgctg 540 gtgtacctga ctcagccagg caatggcaac gagggcagcg tcactggaag ttgttattgt 600 ggtaaaagaa tttcttccga ctccccgcca tcggttcagt tcatgaatcg tctccggaaa 660 cacctgagag cttaccatcg gtgtctatac tacacgaggt tccagctcct ttcctggagc 720 gtgtgtggag gcaacaagga cccatgggtt caggaattga tgagctgtct tgatctcaaa 780 gaatgtggac atgcttactc ggggattgtg gcccaccaga agcatttact tcctaccagc 840 cccccaactt ctcaggcctc agagggggca tcttcagata tccacacccc tgcccagatg 900 ctcctgtcca ccttgcagtc cactcagcgc cccaccctcc cagtaggatc actgtcctcg 960 gacaaagagc tcactcgtcc caatgaaacc accattcaca ctgcgggcca cagtctggca 1020 gttgggcctg aggctgggga gaaccagaag cagccggaaa aaaatgctgg tcccacagcc 1080 aggacatcag ccacagtgcc ggtcctgtgc ctcctggcca tcatcttcat cctcaccgca 1140 gccctttcct atgtgctgtg caagaggagg agggggcagt caccgcagtc ctctccagat 1200 ctgccggttc attatatacc tgtggcacct gactctaata cctgagccaa gaatggaagc 1260 ttgtgaggag acggactcta tgttgcccag gctgttatgg aactcctgag tcaagtgatc 1320 ctcccacctt ggcctctgaa ggtgcgagga ttataggcgt cacctaccac atccagccta 1380 cacgtatttg ttaatatcta acataggact aaccagccac tgccctctct taggcccctc 1440 atttaaaaac ggttatacta taaaatctgc ttttcacact gggtgataat aacttggaca 1500 aattctatgt gtattttgtt ttgttttgct ttgctttgtt ttgagacgga gtctcgctct 1560 gtcatccagg ctggagtgca gtggcatgat ctcggctcac tgcaaccccc atctcccagg 1620 ttcaagcgat tctcctgcct cctcctaagt agctgggact acaggtgctc accaccacac 1680 ccggctaatt ttttgtattt ttagtagaga cggggtttca ccatgttgac caggctggtc 1740 tcgaactcct gacctggtga tctgcccacc caggcctccc aaagtgctgg gattaaaggt 1800 gtgagccacc atgcctggcc ctatgtgtgt tttttaacta ctaaaaatta tttttgtaat 1860 gattgagtct tctttatgga aacaactggc ctcagccctt gcgcccttac tgtgattcct 1920 ggcttcattt tttgctgatg gttccccctc gtcccaaatc tctctcccag tacaccagtt 1980 gttcctcccc cacctcagcc ctctcctgca tcctcctgta cccgcaacga aggcctgggc 2040 tttcccaccc tccctcctta gcaggtgccg tgctgggaca ccatacgggt tggtttcacc 2100 tcctcagtcc cttgcctacc ccagtgagag tctgatcttg tttttattgt tattgctttt 2160 attattattg cttttattat cattaaaact ctagttcttg ttttgtctct caaaaaaaaa 2220 aaaaaaaaaa aaaaaaaaaa aaaaaaaac 2249 <210> 15 <211> 4759 <212> DNA <213> Homo sapiens <400> 15 cctcatttcc cctgctttcc ccgctcgcca cgccctcctc ctacccggct ttaaagctag tgaggcacag 120 cctgcgggga acgtagctag ctgcaagcag aggccggcat gaccaccgag cagcgacgca 180 gcctgcaagc cttccaggat tatatccgga agaccctgga ccctacctac atcctgagct 240 acatggcccc ctggtttagg gaggaagagg tgcagtatat tcaggctgag aaaaacaaca 300 agggcccaat ggaggctgcc acactttttc tcaagttcct gttggagctc caggaggaag 360 gctggttccg tggctttttg gatgccctag accatgcagg ttattctgga ctttatgaag 420 ccattgaaag ttgggatttc aaaaaaattg aaaagttgga ggagtataga ttacttttaa 480 aacgtttaca accagaattt aaaaccagaa ttatcccaac cgatatcatt tctgatctgt 540 ctgaatgttt aattaatcag gaatgtgaag aaattctaca gatttgctct actaagggga 600 tgatggcagg tgcagagaaa ttggtggaat gccttctcag atcagacaag gaaaactggc 660 ccaaaacttt gaaacttgct ttggagaaag aaaggaacaa gttcagtgaa ctgtggattg 720 tagagaaagg tataaaagat gttgaaacag aagatcttga ggataagatg gaaacttctg 780 acatacagat tttctaccaa gaagatccag aatgccagaa tcttagtgag aattcatgtc 840 caccttcaga agtgtctgat acaaacttgt acagcccatt taaaccaaga aattaccaat 900 tagagcttgc tttgcctgct atgaaaggaa aaaacacaat aatatgtgct cctacaggtt 960 gtggaaaaac ctttgtttca ctgcttatat gtgaacatca tcttaaaaaa ttcccacaag 1020 gacaaaaggg gaaagttgtc ttttttgcga atcagatccc agtgtatgaa cagcagaaat 1080 ctgtattctc aaaatacttt gaaagacatg ggtatagagt tacaggcatt tctggagcaa 1140 cagctgagaa tgtcccagtg gaacagattg ttgagaacaa tgacatcatc attttaactc 1200 cacagattct tgtgaacaac cttaaaaagg gaacgattcc atcactatcc atctttactt 1260 tgatgatatt tgatgaatgc cacaacacta gtaaacaaca cccgtacaat atgatcatgt 1320 ttaattatct agatcagaaa cttggaggat cttcaggccc actgccccag gtcattgggc 1380 tgactgcctc ggttggtgtt ggggatgcca aaaacacaga tgaagccttg gattatatct 1440 gcaagctgtg tgcttctctt gatgcgtcag tgatagcaac agtcaaacac aatctggagg 1500 aactggagca agttgtttat aagccccaga agtttttcag gaaagtggaa tcacggatta 1560 gcgacaaatt taaatacatc atagctcagc tgatgaggga cacagagagt ctggcaaaga 1620 gaatctgcaa agacctcgaa aacttatctc aaattcaaaa tagggaattt ggaacacaga 1680 aatatgaaca atggattgtt acagttcaga aagcatgcat ggtgttccag atgccagaca 1740 aagatgaaga gagcaggatt tgtaaagccc tgtttttata cacttcacat ttgcggaaat 1800 ataatgatgc cctcattatc agtgagcatg cacgaatgaa agatgctctg gattacttga 1860 aagacttctt cagcaatgtc cgagcagcag gattcgatga gattgagcaa gatcttactc 1920 agagatttga agaaaagctg caggaactag aaagtgtttc cagggatccc agcaatgaga 1980 atcctaaact tgaagacctc tgcttcatct tacaagaaga gtaccactta aacccagaga 2040 caataacaat tctctttgtg aaaaccagag cacttgtgga cgctttaaaa aattggattg 2100 aaggaaatcc taaactcagt tttctaaaac ctggcatatt gactggacgt ggcaaaacaa 2160 atcagaacac aggaatgacc ctcccggcac agaagtgtat attggatgca ttcaaagcca 2220 gtggagatca caatattctg attgccacct cagttgctga tgaaggcatt gacattgcac 2280 agtgcaatct tgtcatcctt tatgagtatg tgggcaatgt catcaaaatg atccaaacca 2340 gaggcagagg aagagcaaga ggtagcaagt gcttccttct gactagtaat gctggtgtaa 2400 ttgaaaaaga acaaataaac atgtacaaag aaaaaatgat gaatgactct attttacgcc 2460 ttcagacatg ggacgaagca gtatttaggg aaaagattct gcatatacag actcatgaaa 2520 aattcatcag agatagtcaa gaaaaaccaa aacctgtacc tgataaggaa aataaaaaac 2580 tgctctgcag aaagtgcaaa gccttggcat gttacacagc tgacgtaaga gtgatagagg 2640 aatgccatta cactgtgctt ggagatgctt ttaaggaatg ctttgtgagt agaccacatc 2700 ccaagccaaa gcagttttca agttttgaaa aaagagcaaa gatattctgt gcccgacaga 2760 actgcagcca tgactgggga atccatgtga agtacaagac atttgagatt ccagttataa 2820 aaattgaaag ttttgtggtg gaggatattg caactggagt tcagacactg tactcgaagt 2880 ggaaggactt tcattttgag aagataccat ttgatccagc agaaatgtcc aaatgatatc 2940 aggtcctcaa tcttcagcta cagggaatga gtaactttga gtggagaaga aacaaacata 3000 gtgggtataa tcatggatcg cttgtacccc tgtgaaaata tattttttaa aaatatcttt 3060 agcagtttgt actatattat atatgcaaag cacaaatgag tgaatcacag cactgagtat 3120 tttgtaggcc aacagagctc atagtacttg ggaaaaatta aaaagcctca tttctagcct 3180 tctttttaga gtcaactgcc aacaaacaca cagtaatcac tctgtacaca ctgggataga 3240 tgaatgaatg gaatgttggg aatttttatc tccctttgtc tccttaacct actgtaaact 3300 ggcttttgcc cttaacaatc tactgaaatt gttcttttga aggttaccag tgactctggt 3360 tgccaaatcc actgggcact tcttaacctt ctatttgacc tctgcgcatt tggccctgtt 3420 gagcactctt cttgaagctc tccctgggct tctctctctt ctagttctat tctagtcttt 3480 ttttattgag tcctcctctt tgctgatccc ttccaagggt tcaatatata tacatgtata 3540 tactgtacat atgtatatgt aactaatata catacataca ggtatgtata tgtaatggtt 3600 atatgtactc atgttcctgg tgtagcaacg tgtggtatgg ctacacagag aacatgagaa 3660 cataaagcca tttttatgct tactactaaa agctgtccac tgtagagttg ctgtatgtag 3720 caatgtgtat ccactctaca gtggtcagct tttagtagag agcataaaaa tgataaaata 3780 cttcttgaaa acttagttta ctatacatct tgccctatta atatgttctc ttaacgtgtg 3840 ccattgttct ctttgaccat tttcctataa tgatgttgat gttcaacacc tggactgaat 3900 gtctgttctc agatcccttg gatgttacag atgaggcagt ctgactgtcc tttctacttg 3960 aaagattaga atatgtatcc aaatggcatt cacgtgtcac ttagcaaggt ttgctgatgc 4020 ttcaaagagc ttagtttgcg gtttcctgga cgtggaaaca agtatctgag ttccctggag 4080 atcaacggga tgaggtgtta cagctgcctc cctcttcatg caatctggtg agcagtggtg 4140 caggcgggga gccagagaaa cttgccagtt atataacttc tctttggctt ttcttcatct 4200 gtaaaacaag gataatactg aactgtaagg gttagtggag agtttttaat taaaagaatg 4260 tgtgaaaagt acatgacaca gtagttgctt gataatagtt actagtagta gtattcttac 4320 taagacccaa tacaaatgga ttatttaaac caagtttatg agttggtttt ttttcatttt 4380 ctatttgtat tttattaaga gtgtcttttc ttatgtgatt ttttttaatt gctatttgat 4440 atggtttggc tatatgtccc cacccaaatc tcatcttgaa ttataatccc catgtgtcaa 4500 gggagggacc tgacgggagg tgattggatc acgggggcag ttgtccccat gctgttcttg 4560 ggatagtgag ttagttctca tgagatctga tggttttata agtgtttgac aattcctcct 4620 ttacacacac tctctctctc atctgctgcc atgtaagact tgcctgcttc cccttctgcc 4680 atgattgtaa gtttcctgag gcctcctcag ccatgtggaa ctgtgaatct attaagcctc 4740 ttttctttat aaatgaaaa 4759 <210> 16 <211> 484 <212> DNA <213> Homo sapiens <400> 16 tcccttcagt tccgtcgacg aggttgtgca atccaccagt cttataaata cagtgacgct 60 ccagcctctg gaagcctctg tcagctcagc ctccaaagga gccagcgtct ccccagttcc 120 tgaaatcctg ggtgttgcct gccagtcgcc atgagaactt cctaccttct gctgtttact 180 ctctgcttac ttttgtctga gatggcctca ggtggtaact ttctcacagg ccttggccac 240 agatctgatc attacaattg cgtcagcagt ggagggcaat gtctctattc tgcctgcccg 300 atctttacca aaattcaagg cacctgttac agagggaagg ccaagtgctg caagtgagct 360 gggagtgacc agaagaaatg acgcagaagt gaaatgaact ttttataagc attcttttaa 420 taaaggaaaa ttgcttttga agtatacctc ctttgggcca aaaaaaaaaa aaaaaaaaaa 480 aaaa 484 <210> 17 <211> 3366 <212> DNA <213> Homo sapiens <400> 17 cgtgggattt ccagaccgcg gctttctaat cggctcggga ggaagctctg cagctctctt 60 gggaattaag ctcaatctct ggactctctc tctttctctt tctccccctc cctctcctgc 120 gaagaagctc aagacaaaac caggaagccg gcgaccctca cctcctcggg ggctgggagg 180 aaggaggaaa acgaaagtcg ccgccgccgc gctgtccccc gagagctgcc tttcctcggg 240 catccctggg gctgccgcgg gacctcgcag ggcggatata aagaaccgcg gccttgggaa 300 gaggcggaga ccggctttta aagaaagaag tcctgggtcc tgcggtctgg ggcgaggcaa 360 gggcgctttt ctgcccacgc tccccgtggc ccatcgatcc cccgcgcgtc cgccgctgtt 420 ctaaggagag aagtgggggc cccccaggct cgcgcgtgga gcgaagcagc atgggcagtc 480 ggtgcgcgct ggccctggcg gtgctctcgg ccttgctgtg tcaggtctgg agctctgggg 540 tgttcgaact gaagctgcag gagttcgtca acaagaaggg gctgctgggg aaccgcaact 600 gctgccgcgg gggcgcgggg ccaccgccgt gcgcctgccg gaccttcttc cgcgtgtgcc 660 tcaagcacta ccaggccagc gtgtcccccg agccgccctg cacctacggc agcgccgtca 720 cccccgtgct gggcgtcgac tccttcagtc tgcccgacgg cgggggcgcc gactccgcgt 780 tcagcaaccc catccgcttc cccttcggct tcacctggcc gggcaccttc tctctgatta 840 ttgaagctct ccacacagat tctcctgatg acctcgcaac agaaaaccca gaaagactca 900 tcagccgcct ggccacccag aggcacctga cggtgggcga ggagtggtcc caggacctgc 960 acagcagcgg ccgcacggac ctcaagtact cctaccgctt cgtgtgtgac gaacactact 1020 acggagaggg ctgctccgtt ttctgccgtc cccgggacga tgccttcggc cacttcacct 1080 gtggggagcg tggggagaaa gtgtgcaacc ctggctggaa agggccctac tgcacagagc 1140 cgatctgcct gcctggatgt gatgagcagc atggattttg tgacaaacca ggggaatgca 1200 agtgcagagt gggctggcag ggccggtact gtgacgagtg tatccgctat ccaggctgtc 1260 tccatggcac ctgccagcag ccctggcagt gcaactgcca ggaaggctgg gggggccttt 1320 tctgcaacca ggacctgaac tactgcacac accataagcc ctgcaagaat ggagccacct 1380 gcaccaacac gggccagggg agctacactt gctcttgccg gcctgggtac acaggtgcca 1440 cctgcgagct ggggattgac gagtgtgacc ccagcccttg taagaacgga gggagctgca 1500 cggatctcga gaacagctac tcctgtacct gcccacccgg cttctacggc aaaatctgtg 1560 aattgagtgc catgacctgt gcggacggcc cttgctttaa cgggggtcgg tgctcagaca 1620 gccccgatgg agggtacagc tgccgctgcc ccgtgggcta ctccggcttc aactgtgaga 1680 agaaaattga ctactgcagc tcttcaccct gttctaatgg tgccaagtgt gtggacctcg 1740 gtgatgccta cctgtgccgc tgccaggccg gcttctcggg gaggcactgt gacgacaacg 1800 tggacgactg cgcctcctcc ccgtgcgcca acgggggcac ctgccgggat ggcgtgaacg 1860 acttctcctg cacctgcccg cctggctaca cgggcaggaa ctgcagtgcc cccgtcagca 1920 ggtgcgagca cgcaccctgc cacaatgggg ccacctgcca cgagaggggc caccgctatg 1980 tgtgcgagtg tgcccgaggc tacgggggtc ccaactgcca gttcctgctc cccgagctgc 2040 ccccgggccc agcggtggtg gacctcactg agaagctaga gggccagggc gggccattcc 2100 cctgggtggc cgtgtgcgcc ggggtcatcc ttgtcctcat gctgctgctg ggctgtgccg 2160 ctgtggtggt ctgcgtccgg ctgaggctgc agaagcaccg gcccccagcc gacccctgcc 2220 ggggggagac ggagaccatg aacaacctgg ccaactgcca gcgtgagaag gacatctcag 2280 tcagcatcat cggggccacg cagatcaaga acaccaacaa gaaggcggac ttccacgggg 2340 accacagcgc cgacaagaat ggcttcaagg cccgctaccc agcggtggac tataacctcg 2400 tgcaggacct caagggtgac gacaccgccg tcagggacgc gcacagcaag cgtgacacca 2460 agtgccagcc ccagggctcc tcaggggagg agaaggggac cccgaccaca ctcaggggtg 2520 gagaagcatc tgaaagaaaa aggccggact cgggctgttc aacttcaaaa gacaccaagt 2580 accagtcggt gtacgtcata tccgaggaga aggatgagtg cgtcatagca actgaggtgt 2640 aaaatggaag tgagatggca agactcccgt ttctcttaaa ataagtaaaa ttccaaggat 2700 atatgcccca acgaatgctg ctgaagagga gggaggcctc gtggactgct gctgagaaac 2760 cgagttcaga ccgagcaggt tctcctcctg aggtcctcga cgcctgccga cagcctgtcg 2820 cggcccggcc gcctgcggca ctgccttccg tgacgtcgcc gttgcactat ggacagttgc 2880 tcttaagaga atatatattt aaatgggtga actgaattac gcataagaag catgcactgc 2940 ctgagtgtat attttggatt cttatgagcc agtcttttct tgaattagaa acacaaacac 3000 tgcctttatt gtcctttttg atacgaagat gtgctttttc tagatggaaa agatgtgtgt 3060 tattttttgg atttgtaaaa atatttttca tgatatctgt aaagcttgag tattttgtga 3120 tgttcgtttt ttataattta aattttggta aatatgtaca aaggcacttc gggtctatgt 3180 gactatattt ttttgtatat aaatgtattt atggaatatt gtgcaaatgt tatttgagtt 3240 ttttactgtt ttgttaatga agaaattcct ttttaaaata tttttccaaa ataaatttta 3300 tgaatgacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3360 aaaaaa 3366 <210> 18 <211> 1746 <212> DNA <213> Homo sapiens <400> 18 tgcacagcct ctcttaaaac aacatgccac agttaaaact tacttcagtt tggacaacta 60 ctcacagcta ctacacagag acccgaacga gtcactgata tacacctgga ccaccaccaa 120 tggatataca aatggcaaac aattttactc cgccctctgc aactcctcag ggaaatgact 180 gtgacctcta tgcacatcac agcacggcca ggatagtaat gcctctgcat tacagcctcg 240 tcttcatcat tgggctcgtg ggaaacttac tagccttggt cgtcattgtt caaaacagga 300 aaaaaatcaa ctctaccacc ctctattcaa caaatttggt gatttctgat atacttttta 360 ccaccgcttt gcctacacga atagcctact atgcaatggg ctttgactgg agaatcggag 420 atgccttgtg taggataact gcgctagtgt tttacatcaa cacatatgca ggtgtgaact 480 ttatgacctg cctgagtatt gaccgcttca ttgctgtggt gcaccctcta cgctacaaca 540 agataaaaag gattgaacat gcaaaaggcg tgtgcatatt tgtctggatt ctagtatttg 600 ctcagacact cccactcctc atcaacccta tgtcaaagca ggaggctgaa aggattacat 660 gcatggagta tccaaacttt gaagaaacta aatctcttcc ctggattctg cttggggcat 720 gtttcatagg atatgtactt ccacttataa tcattctcat ctgctattct cagatctgct 780 gcaaactctt cagaactgcc aaacaaaacc cactcactga gaaatctggt gtaaacaaaa 840 aggctctcaa cacaattatt cttattattg ttgtgtttgt tctctgtttc acaccttacc 900 atgttgcaat tattcaacat atgattaaga agcttcgttt ctctaatttc ctggaatgta 960 gccaaagaca ttcgttccag atttctctgc actttacagt atgcctgatg aacttcaatt 1020 gctgcatgga cccttttatc tacttctttg catgtaaagg gtataagaga aaggttatga 1080 ggatgctgaa acggcaagtc agtgtatcga tttctagtgc tgtgaagtca gcccctgaag 1140 aaaattcacg tgaaatgaca gaaacgcaga tgatgataca ttccaagtct tcaaatggaa 1200 agtgaaatgg attgtatttt ggtttatagt gacgtaaact gtatgacaaa ctttgcagga 1260 cttcccttat aaagcaaaat aattgttcag cttccaatta gtattctttt atatttcttt 1320 cattgggcac tttcccatct ccaactcgga agtaagccca agagaacaac ataaagcaaa 1380 caacataaag cacaataaaa atgcaaataa atatttcatt tttatttgta aacgaataca 1440 ccaaaaggag gcgctcttaa taactcccaa tgtaaaaagt tttgttttaa taaaaaattt 1500 aattattatt tcttgccaac aaatggctag aaaggactga atagattata tattgccaga 1560 tgttaatact gtaacatact ttttaaataa catatttctt aaatccaaat ttctctcaat 1620 gttagattta attccctcaa taacaccaat gttttgtttt gtttcgttct gggtcataaa 1680 actttgttaa ggaactcttt tggaataaag agcaggatgc tgcaaagtta aaaaaaaaaa 1740 aaaaaa 1746 <210> 19 <211> 1149 <212> DNA <213> Homo sapiens <400> 19 ccgcagccat gaccccgcag cttctcctgg cccttgtcct ctgggccagc tgcccgccct 60 gcagtggaag gaaagggccc ccagcagctc tgacactgcc ccgggtgcaa tgccgagcct 120 ctcggtaccc gatcgccgtg gattgctcct ggaccctgcc gcctgctcca aactccacca 180 gccccgtgtc cttcattgcc acgtacaggc tcggcatggc tgcccggggc cacagctggc 240 cctgcctgca gcagacgcca acgtccacca gctgcaccat cacggatgtc cagctgttct 300 ccatggctcc ctacgtgctc aatgtcaccg ccgtccaccc ctggggctcc agcagcagct 360 tcgtgccttt cataacagag cacatcatca agcccgaccc tccagaaggc gtgcgcctaa 420 gccccctcgc tgagcgccag ctacaggtgc agtgggagcc tcccgggtcc tggcccttcc 480 cagagatctt ctcactgaag tactggatcc gttacaagcg tcagggagct gcgcgcttcc 540 accgggtggg gcccattgaa gccacgtcct tcatcctcag ggctgtgcgg ccccgagcca 600 ggtactacgt ccaagtggcg gctcaggacc tcacagacta cggggaactg agtgactgga 660 gtctccccgc cactgccaca atgagcctgg gcaagtagca agggcttccc gctgcctcca 720 gacagcacct gggtcctcgc caccctaagc cccgggacac ctgttggagg gcggatggga 780 tctgcctagc ctgggctgga gtccttgctt tgctgctgct gagctgccgg gcaacctcag 840 atgaccgact tttccctttg agcctcagtt tctctagctg agaaatggag atgtactact 900 ctctccttta cctttacctt taccacagtg cagggctgac tgaactgtca ctgtgagata 960 ttttttattg tttaattaga aaagaattgt tgttgggctg ggcgcagtgg atcgcacctg 1020 taatcccagt cactgggaag ccgacgtggg agggtagctt gaggccagga gctcgaaacc 1080 agtccgggcc acacagcaag accccatctc taaaaaatta atataaatat aaaataaaaa 1140 aaaaaaaaa 1149 <210> 20 <211> 2808 <212> DNA <213> Homo sapiens <400> 20 gcggcggcgg cggcgcagtt tgctcatact ttgtgacttg cggtcacagt ggcattcagc 60 tccacacttg gtagaaccac aggcacgaca agcatagaaa catcctaaac aatcttcatc 120 gaggcatcga ggtccatccc aataaaaatc aggagaccct ggctatcata gaccttagtc 180 ttcgctggta tactcgctgt ctgtcaacca gcggttgact ttttttaagc cttctttttt 240 ctcttttacc agtttctgga gcaaattcag tttgccttcc tggatttgta aattgtaatg 300 acctcaaaac tttagcagtt cttccatctg actcaggttt gcttctctgg cggtcttcag 360 aatcaacatc cacacttccg tgattatctg cgtgcatttt ggacaaagct tccaaccagg 420 atacgggaag aagaaatggc tggtgatctt tcagcaggtt tcttcatgga ggaacttaat 480 acataccgtc agaagcaggg agtagtactt aaatatcaag aactgcctaa ttcaggacct 540 ccacatgata ggaggtttac atttcaagtt ataatagatg gaagagaatt tccagaaggt 600 gaaggtagat caaagaagga agcaaaaaat gccgcagcca aattagctgt tgagatactt 660 aataaggaaa agaaggcagt tagtccttta ttattgacaa caacgaattc ttcagaagga 720 ttatccatgg ggaattacat aggccttatc aatagaattg cccagaagaa aagactaact 780 gtaaattatg aacagtgtgc atcgggggtg catgggccag aaggatttca ttataaatgc 840 aaaatgggac agaaagaata tagtattggt acaggttcta ctaaacagga agcaaaacaa 900 ttggccgcta aacttgcata tcttcagata ttatcagaag aaacctcagt gaaatctgac 960 tacctgtcct ctggttcttt tgctactacg tgtgagtccc aaagcaactc tttagtgacc 1020 agcacactcg cttctgaatc atcatctgaa ggtgacttct cagcagatac atcagagata 1080 aattctaaca gtgacagttt aaacagttct tcgttgctta tgaatggtct cagaaataat 1140 caaaggaagg caaaaagatc tttggcaccc agatttgacc ttcctgacat gaaagaaaca 1200 aagtatactg tggacaagag gtttggcatg gattttaaag aaatagaatt aattggctca 1260 ggtggatttg gccaagtttt caaagcaaaa cacagaattg acggaaagac ttacgttatt 1320 aaacgtgtta aatataataa cgagaaggcg gagcgtgaag taaaagcatt ggcaaaactt 1380 gatcatgtaa atattgttca ctacaatggc tgttgggatg gatttgatta tgatcctgag 1440 accagtgatg attctcttga gagcagtgat tatgatcctg agaacagcaa aaatagttca 1500 aggtcaaaga ctaagtgcct tttcatccaa atggaattct gtgataaagg gaccttggaa 1560 caatggattg aaaaaagaag aggcgagaaa ctagacaaag ttttggcttt ggaactcttt 1620 gaacaaataa caaaaggggt ggattatata cattcaaaaa aattaattca tagagatctt 1680 aagccaagta atatattctt agtagataca aaacaagtaa agattggaga ctttggactt 1740 gtaacatctc tgaaaaatga tggaaagcga acaaggagta agggaacttt gcgatacatg 1800 agcccagaac agatttcttc gcaagactat ggaaaggaag tggacctcta cgctttgggg 1860 ctaattcttg ctgaacttct tcatgtatgt gacactgctt ttgaaacatc aaagtttttc 1920 acagacctac gggatggcat catctcagat atatttgata aaaaagaaaa aactcttcta 1980 cagaaattac tctcaaagaa acctgaggat cgacctaaca catctgaaat actaaggacc 2040 ttgactgtgt ggaagaaaag cccagagaaa aatgaacgac acacatgtta gagcccttct 2100 ctgctaggga atatcaatag atatttacct tttattttaa tgtttccttt aattttttac tatttttact 2220 aatctttctg cagaaacaga aaggttttct tctttttgct tcaaaaacat tcttacattt 2280 tactttttcc tggctcatct ctttattctt tttttttttt ttaaagacag agtctcgctc 2340 tgttgcccag gctggagtgc aatgacacag tcttggctca ctgcaacttc tgcctcttgg 2400 gttcaagtga ttctcctgcc tcagcctcct gagtagctgg attacaggca tgtgccaccc 2460 acccaactaa tttttgtgtt tttaataaag acagggtttc accatgttgg ccaggctggt 2520 ctcaaactcc tgacctcaag taatccacct gcctcggcct cccaaagtgc tgggattaca 2580 gggatgagcc accgcgccca gcctcatctc tttgttctaa agatggaaaa accaccccca 2640 aattttcttt ttatactatt aatgaatcaa tcaattcata tctatttatt aaatttctac 2700 cgcttttagg ccaaaaaaat gtaagatcgt tctctgcctc acatagctta caagccagct 2760 ggagaaatat ggtactcatt aaaaaaaaaa aaaaagtgat gtacaacc 2808 <210> 21 <211> 1909 <212> DNA <213> Homo sapiens <400> 21 gaggtgtttc ccttagctat ggaaactcta taagagagat ccagcttgcc tcctcttgag 60 cagtcagcaa cagggtcccg tccttgacac ctcagcctct acaggactga gaagaagtaa 120 aaccgtttgc tggggctggc ctgactcacc agctgccatg cagcagccct tcaattaccc 180 atatccccag atctactggg tggacagcag tgccagctct ccctgggccc ctccaggcac 240 agttcttccc tgtccaacct ctgtgcccag aaggcctggt caaaggaggc caccaccacc 300 accgccaccg ccaccactac cacctccgcc gccgccgcca ccactgcctc cactaccgct 360 gccacccctg aagaagagag ggaaccacag cacaggcctg tgtctccttg tgatgttttt 420 catggttctg gttgccttgg taggattggg cctggggatg tttcagctct tccacctaca 480 gaaggagctg gcagaactcc gagagtctac cagccagatg cacacagcat catctttgga 540 gaagcaaata ggccacccca gtccaccccc tgaaaaaaag gagctgagga aagtggccca 600 tttaacaggc aagtccaact caaggtccat gcctctggaa tgggaagaca cctatggaat 660 tgtcctgctt tctggagtga agtataagaa gggtggcctt gtgatcaatg aaactgggct 720 gtactttgta tattccaaag tatacttccg gggtcaatct tgcaacaacc tgcccctgag 780 ccacaaggtc tacatgagga actctaagta tccccaggat ctggtgatga tggaggggaa 840 gatgatgagc tactgcacta ctgggcagat gtgggcccgc agcagctacc tgggggcagt 900 gttcaatctt accagtgctg atcatttata tgtcaacgta tctgagctct ctctggtcaa 960 ttttgaggaa tctcagacgt ttttcggctt atataagctc taagagaagc actttgggat 1020 tctttccatt atgattcttt gttacaggca ccgagaatgt tgtattcagt gagggtcttc 1080 ttacatgcat ttgaggtcaa gtaagaagac atgaaccaag tggaccttga gaccacaggg 1140 ttcaaaatgt ctgtagctcc tcaactcacc taatgtttat gagccagaca aatggaggaa 1200 tatgacggaa gaacatagaa ctctgggctg ccatgtgaag agggagaagc atgaaaaagc 1260 agctaccagg tgttctacac tcatcttagt gcctgagagt atttaggcag attgaaaagg 1320 acacctttta actcacctct caaggtgggc cttgctacct caagggggac tgtctttcag 1380 atacatggtt gtgacctgag gatttaaggg atggaaaagg aagactagag gcttgcataa 1440 taagctaaag aggctgaaag aggccaatgc cccactggca gcatcttcac ttctaaatgc 1500 atatcctgag ccatcggtga aactaacaga taagcaagag agatgttttg gggactcatt 1560 tcattcctaa cacagcatgt gtatttccag tgcaattgta ggggtgtgtg tgtgtgtgtg 1620 tgtgtgtgtg tgtgtatgac taaagagaga atgtagatat tgtgaagtac atattaggaa 1680 aatatgggtt gcatttggtc aagattttga atgcttcctg acaatcaact ctaatagtgc 1740 ttaaaaatca ttgattgtca gctactaatg atgttttcct ataatataat aaatatttat 1800 gtagatgtgc atttttgtga aatgaaaaca tgtaataaaa agtatatgtt aggatacaaa 1860 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1909 <210> 22 <211> 2881 <212> DNA <213> Homo sapiens <400> 22 acagaagtgc tagaagccag tgctcgtgaa ctaaggagaa aaagaacaga caagggaaca 60 gcctggacat ggcatcagag atccacatga caggcccaat gtgcctcatt gagaacacta 120 atgggcgact gatggcgaat ccagaagctc tgaagatcct ttctgccatt acacagccta 180 tggtggtggt ggcaattgtg ggcctctacc gcacaggcaa atcctacctg atgaacaagc 240 tggctggaaa gaaaaagggc ttctctctgg gctccacggt gcagtctcac actaaaggaa 300 tctggatgtg gtgtgtgccc caccccaaga agccaggcca catcctagtt ctgctggaca 360 ccgagggtct gggagatgta gagaagggtg acaaccagaa tgactcctgg atcttcgccc 420 tggccgtcct cctgagcagc accttcgtgt acaatagcat aggaaccatc aaccagcagg 480 ctatggacca actgtactat gtgacagagc tgacacatag aatccgatca aaatcctcac 540 ctgatgagaa tgagaatgag gttgaggatt cagctgactt tgtgagcttc ttcccagact 600 ttgtgtggac actgagagat ttctccctgg acttggaagc agatggacaa cccctcacac 660 cagatgagta cctgacatac tccctgaagc tgaagaaagg taccagtcaa aaagatgaaa 720 cttttaacct gcccagactc tgtatccgga aattcttccc aaagaaaaaa tgctttgtct 780 ttgatcggcc cgttcaccgc aggaagcttg cccagctcga gaaactacaa gatgaagagc 840 tggaccccga atttgtgcaa caagtagcag acttctgttc ctacatcttt agtaattcca 900 aaactaaaac tctttcagga ggcatccagg tcaacgggcc tcgtctagag agcctggtgc 960 tgacctacgt caatgccatc agcagtgggg atctgccgtg catggagaac gcagtcctgg 1020 ccttggccca gatagagaac tcagctgcag tgcaaaaggc tattgcccac tatgaacagc 1080 agatgggcca gaaggtgcag ctgcccacag aaagcctcca ggagctgctg gacctgcaca 1140 gggacagtga gagagaggcc attgaagtct tcatcaggag ttccttcaaa gatgtggacc 1200 atctatttca aaaggagtta gcggcccagc tagaaaaaaa gcgggatgac ttttgtaaac 1260 agaatcagga agcatcatca gatcgttgct caggtttact tcaggtcatt ttcagtcctc 1320 tagaagaaga agtgaaggcg ggaatttatt cgaaaccagg gggctatcgt ctctttgttc 1380 agaagctaca agacctgaag aaaaagtact atgaggaacc gaggaagggg atacaggctg 1440 aagagattct gcagacatac ttgaaatcca aggagtctat gactgatgca attctccaga 1500 cagaccagac tctcacagaa aaagaaaagg agattgaagt ggaacgtgtg aaagctgagt 1560 ctgcacaggc ttcagcaaaa atgttgcagg aaatgcaaag aaagaatgag cagatgatgg 1620 aacagaagga gaggagttat caggaacact tgaaacaact gactgagaag atggagaacg 1680 acagggtcca gttgctgaaa gagcaagaga ggaccctcgc tcttaaactt caggaacagg 1740 agcaactact aaaagaggga tttcaaaaag aaagcagaat aatgaaaaat gagatacagg 1800 atctccagac gaaaatgaga cgacgaaagg catgtaccat aagctaaaga ccagagcctt 1860 cctgtcaccc ctaaccaagg cataattgaa acaattttag aatttggaac aagcgtcact 1920 acatttgata ataattagat cttgcatcat aacaccaaaa gtttataaag gcatgtggta 1980 caatgatcaa aatcatgttt tttcttaaaa aaaaaaaaaa gactgtaaat tgtgcaacaa 2040 agatgcattt acctctgtat caactcagga aatctcataa gctggtacca ctcaggagaa 2100 gtttattctt ccagatgacc agcagtagac aaatggatac tgagcagagt cttaggtaaa 2160 agtcttggga aatatttggg cattggtctg gccaagtcta caatgtccca atatcaagga 2220 caaccaccct agcttcttag tgaagacaat gtacagttat ccattagatc aagactacac 2280 ggtctatgag caataatgtg atttctggac attgcccatg tataatcctc actgatgatt 2340 tcaagctaaa gcaaaccacc ttatacagag atctagaatc tctttatgtt ctccagagga 2400 aggtggaaga aaccatgggc aggagtagga attgagtgat aaacaattgg gctaatgaag 2460 aaaacttctc ttattgttca gttcatccag attataactt caatgggaca ctttagacca 2520 ttagacaatt gacactggat taaacaaatt cacataatgc caaatacaca atgattatt 2580 agcaacgtat aatttgcaaa gatggacttt aaaagatgct gtgtaactaa actgaaataa 2640 ttcaattact tattatttag aatgttaaag cttatgatag tcttttctaa ttcttaacac 2700 tcatacttga aatctttccg agtttcccca gaagagaata tgggattttt tttgacattt 2760 ttgacccatt taataatgct cttgtgttta cctagtatat gtagactttg tcttatgtgt 2820 caaaagtcct aggaaagtgg ttgatgtttc ttatagcaat taaaaattat ttttgaactg 2880 a 2881 <210> 23 <211> 1158 <212> DNA <213> Homo sapiens <400> 23 gcctgctgct ctggcccctg gtcctgtcct cttctccagc atggtgtgtc tgaagctccc 60 tggaggctcc agcttggcag cgttgacagt gacactgatg gtgctgagct cccgactggc 120 tttcgctggg gacacccgac cacgtttctt ggagctgcgt aagtctgagt gtcatttctt 180 caatgggacg gagcgggtgc ggtacctgga cagatacttc cataaccagg aggagttcct 240 gcgcttcgac agcgacgtgg gggagtaccg ggcggtgacg gagctggggc ggcctgtcgc 300 cgagtcctgg aacagccaga aggacctcct ggagcagaag cggggccggg tggacaatta 360 ctgcagacac aactacgggg ttggtgagag cttcacagtg cagcggcgag tccatcctca 420 ggtgactgtg tatcctgcaa agacccagcc cctgcagcac cacaacctcc tggtctgctc 480 tgtgagtggt ttctatccag gcagcattga agtcaggtgg ttccggaacg gccaggaaga 540 gaaggctggg gtggtgtcca cgggcctgat ccagaatgga gactggacct tccagaccct 600 ggtgatgcta gaaacagttc ctcggagtgg agaggtttac acttgccaag tggagcaccc 660 aagcgtaacg agcgctctca cagtggaatg gagagcacgg tctgaatctg cacagagcaa 720 gatgctgagt ggagtcgggg gctttgtgct gggcctgctc ttccttgggg ccgggctgtt 780 catctacttc aggaatcaga aaggacactc tggacttcag ccaacaggat tcctgagctg 840 aagtgcagat gacaatttaa ggaagaatct tctgccccag ctttgcagga tgaaaagctt 900 tcccgcctgg ctgttattct tccacgagag agggctttct caggacctag ttgctactgg 960 ttcagcaact gcagaaaatg tcctcccttg tggcttcctc agttcctgcc cttggcctga 1020 agtcccagca ttgatggcag cgcctcatct tcaacttttg tgctcccctt tgcctaaacc 1080 ctatggcctc ctgtgcatct gtactcaccc tgtaccacaa acacattaca ttattaaatg 1140 tttctcaaag atggagtt 1158 <210> 24 <211> 2620 <212> DNA <213> Homo sapiens <400> 24 ctgaacgcga ggactgttaa ctgtttctgg caaacatgaa gtcaggcctc tggtatttct 60 ttctcttctg cttgcgcatt aaagttttaa caggagaaat caatggttct gccaattatg 120 agatgtttat atttcacaac ggaggtgtac aaattttatg caaatatcct gacattgtcc 180 agcaatttaa aatgcagttg ctgaaagggg ggcaaatact ctgcgatctc actaagacaa 240 aaggaagtgg aaacacagtg tccattaaga gtctgaaatt ctgccattct cagttatcca 300 acaacagtgt ctcttttttt ctatacaact tggaccattc tcatgccaac tattacttct 360 gcaacctatc aatttttgat cctcctcctt ttaaagtaac tcttacagga ggatatttgc 420 atatttatga atcacaactt tgttgccagc tgaagttctg gttacccata ggatgtgcag 480 cctttgttgt agtctgcatt ttgggatgca tacttatttg ttggcttaca aaaaagaagt 540 attcatccag tgtgcacgac cctaacggtg aatacatgtt catgagagca gtgaacacag 600 ccaaaaaatc tagactcaca gatgtgaccc tataatatgg aactctggca cccaggcatg 660 aagcacgttg gccagttttc ctcaacttga agtgcaagat tctcttattt ccgggaccac 720 ggagagtctg acttaactac atacatcttc tgctggtgtt ttgttcaatc tggaagaatg 780 actgtatcag tcaatgggga ttttaacaga ctgccttggt actgccgagt cctctcaaaa 840 caaacaccct cttgcaacca gctttggaga aagcccagct cctgtgtgct cactgggagt 900 ggaatccctg tctccacatc tgctcctagc agtgcatcag ccagtaaaac aaacacattt 960 acaagaaaaa tgttttaaag atgccagggg tactgaatct gcaaagcaaa tgagcagcca 1020 aggaccagca tctgtccgca tttcactatc atactacctc ttctttctgt agggatgaga 1080 attcctcttt taatcagtca agggagatgc ttcaaagctg gagctatttt atttctgaga 1140 tgttgatgtg aactgtacat tagtacatac tcagtactct ccttcaattg ctgaacccca 1200 gttgaccatt ttaccaagac tttagatgct ttcttgtgcc ctcaattttc tttttaaaaa 1260 tacttctaca tgactgcttg acagcccaac agccactctc aatagagag tatgtcttac 1320 attctttcct ctgctgctca atagttttat atatctatgc atacatatat acacacatat 1380 gtatataaaa ttcataatga atatatttgc ctatattctc cctacaagaa tatttttgct 1440 ccagaaagac atgttctttt ctcaaattca gttaaaatgg tttactttgt tcaagttagt 1500 ggtaggaaac attgcccgga attgaaagca aatttatttt attatcctat tttctaccat 1560 tatctatgtt ttcatggtgc tattaattac aagtttagtt ctttttgtag atcatattaa 1620 aattccaaac aaaatcatct ttaatgggcc agcattctca tggggtagag cagaatattc 1680 atttagcctg aaagctgcag ttactatagg ttgctgtcag actataccca tggtgcctct 1740 gggcttgaca ggtcaaaatg gtccccatca gcctggagca gccctccaga cctgggtgga 1800 attccagggt tgagagactc ccctgagcca gaggccacta ggtattcttg ctcccagagg 1860 ctgaagtcac cctgggaatc acagtggtct acctgcattc ataattccag gatctgtgaa 1920 gagcacatat gtgtcagggc acaattccct ctcataaaaa ccacacagcc tggaaattgg 1980 ccctggccct tcaagatagc cttctttaga atatgatttg gctagaaaga ttcttaaata 2040 tgtggaatat gattattctt agctggaata ttttctctac ttcctgtctg catgcccaag 2100 gcttctgaag cagccaatgt cgatgcaaca acatttgtaa ctttaggtaa actgggatta 2160 tgttgtagtt taacattttg taactgtgtg cttatagttt acaagtgaga cccgatatgt 2220 cattatgcat acttatatta tcttaagcat gtgtaatgct ggatgtgtac agtacagtac 2280 tgaacttgta atttgaatct agtatggtgt tctgttttca gctgacttgg acaacctgac 2340 tggctttgca caggtgttcc ctgagttgtt tgcaggtttc tgtgtgtggg gtggggtatg 2400 gggaggagaa ccttcatggt ggcccacctg gcctggttgt ccaagctgtg cctcgacaca 2460 tcctcatccc cagcatggga cacctcaaga tgaataataa ttcacaaaat ttctgtgaaa 2520 tcaaatccag ttttaagagg agccacttat caaagagatt ttaacagtag taagaaggca 2580 aagaataaac atttgatatt cagcaactga aaaaaaaaaa 2620 <210> 25 <211> 656 <212> DNA <213> Homo sapiens <400> 25 gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc 60 tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca 120 ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg 180 gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga 240 ggagttgtgg ctgtgcccat ggtgctcagt gccatgggct tcactgcggc gggaatcgcc 300 tcgtcctcca tagcagccaa gatgatgtcc gcggcggcca ttgccaatgg gggtggagtt 360 gcctcgggca gccttgtggc tactctgcag tcactgggag caactggact ctccggattg 420 accaagttca tcctgggctc cattgggtct gccattgcgg ctgtcattgc gaggttctac 480 tagctccctg cccctcgccc tgcagagaag agaaccatgc caggggagaa ggcacccagc 540 catcctgacc cagcgaggag ccaactatcc caaatatacc tggggtgaaa tataccaaat 600 tctgcatctc cagaggaaaa taagaaataa agatgaattg ttgcaactct tcaaaa 656 <210> 26 <211> 860 <212> DNA <213> Homo sapiens <400> 26 ccagccttca gccggagaac cgtttactcg ctgctgtgcc catctatcag caggctccgg 60 gctgaagatt gcttctcttc tctcctccaa ggtctagtga cggagcccgc gcgcggcgcc 120 ccttgcagt 180 ggggtggagg caggtgagaa tgcgggtaag gatgcaggta agaaaaagtg ctcggagagc 240 tcggacagcg gctccgggtt ctggaaggcc ctgaccttca tggccgtcgg aggaggactc 300 gcagtcgccg ggctgcccgc gctgggcttc accggcgccg gcatcgcggc caactcggtg 360 gctgcctcgc tgatgagctg gtctgcgatc ctgaatgggg gcggcgtgcc cgccgggggg 420 ctagtggcca cgctgcagag cctcggggct ggtggcagca gcgtcgtcat aggtaatatt 480 ggtgccctga tgggctacgc cacccacaag tatctcgata gtgaggagga tgaggagtag 540 ccagcagctc ccagaacctc ttcttccttc ttggcctaac tcttccagtt aggatctaga 600 actttgcctt tttttttttt tttttttttt tgagatgggt tctcactata ttgtccaggc 660 tagagtgcag tggctattca cagatgcgaa catagtacac tgcagcctcc aactcctagc 720 ctcaagtgat cctcctgtct caacctccca agtaggatta caagcatgcg ccgacgatgc 780 ccagaatcca gaactttgtc tatcactctc cccaacaacc tagatgtgaa aacagaataa 840 acttcaccca gaaaacactt 860 <210> 27 <211> 3434 <212> DNA <213> Homo sapiens <400> 27 gccccgctgc ccacctgccc gcctgcccac ctgcccaggt gcgagtgcag ccccgcgcgc 60 cggcctgaga gccctgtgga caacctcgtc attgtcaggc acagagcggt agaccctgct 120 tctctaagtg ggcagcggac agcggcacgc acatttcacc tgtcccgcag acaacagcac 180 catctgcttg ggagaaccct ctcccttctc tgagaaagaa agatgtcgaa tgggtattcc 240 acagacgaga atttccgcta tctcatctcg tgcttcaggg ccagggtgaa aatgtacatc 300 caggtggagc ctgtgctgga ctacctgacc tttctgcctg cagaggtgaa ggagcagatt 360 cagaggacag tcgccacctc cgggaacatg caggcagttg aactgctgct gagcaccttg 420 gagaagggag tctggcacct tggttggact cgggaattcg tggaggccct ccggagaacc 480 ggcagccctc tggccgcccg ctacatgaac cctgagctca cggacttgcc ctctccatcg 540 tttgagaacg ctcatgatga atatctccaa ctgctgaacc tccttcagcc cactctggtg 600 gacaagcttc tagttagaga cgtcttggat aagtgcatgg aggaggaact gtggacaatt 660 gaagacagaa accggattgc tgctgcagaa aacaatggaa atgaatcagg tgtaagagag 720 ctactaaaaa ggattgtgca gaaagaaaac tggttctctg catttctgaa tgttcttcgt 780 caaacaggaa acaatgaact tgtccaagag ttaacaggct ctgattgctc agaaagcaat 840 gcagagattg agaatttatc acaagttgat ggtcctcaag tggaagagca acttctttca 900 accacagttc agccaaatct ggagaaggag gtctggggca tggagaataa ctcatcagaa 960 tcatcttttg cagattcttc tgtagtttca gaatcagaca caagtttggc agaaggaagt 1020 gtcagctgct tagatgaaag tcttggacat aacagcaaca tgggcagtga ttcaggcacc 1080 atgggaagtg attcagatga agagaatgtg gcagcaagag catccccgga gccagaactc 1140 cagctcaggc cttaccaaat ggaagttgcc cagccagcct tggaagggaa gaatatcatc 1200 atctgcctcc ctacagggag tggaaaaacc agagtggctg tttacattgc caaggatcac 1260 ttagacaaga agaaaaaagc atctgagcct ggaaaagtta tagttcttgt caataaggta 1320 ctgctagttg aacagctctt ccgcaaggag ttccaaccat ttttgaagaa atggtatcgt 1380 gttattggat taagtggtga tacccaactg aaaatatcat ttccagaagt tgtcaagtcc 1440 tgtgatatta ttatcagtac agctcaaatc cttgaaaact ccctcttaaa cttggaaaat 1500 ggagaagatg ctggtgttca attgtcagac ttttccctca ttatcattga tgaatgtcat 1560 cacaccaaca aagaagcagt gtataataac atcatgaggc attatttgat gcagaagttg 1620 aaaaacaata gactcaagaa agaaaacaaa ccagtgattc cccttcctca gatactggga 1680 ctaacagctt cacctggtgt tggaggggcc acgaagcaag ccaaagctga agaacacatt 1740 ttaaaactat gtgccaatct tgatgcattt actattaaaa ctgttaaaga aaaccttgat 1800 caactgaaaa accaaataca ggagccatgc aagaagtttg ccattgcaga tgcaaccaga 1860 gaagatccat ttaaagagaa acttctagaa ataatgacaa ggattcaaac ttattgtcaa 1920 atgagtccaa tgtcagattt tggaactcaa ccctatgaac aatgggccat tcaaatggaa 1980 aaaaaagctg caaaagaagg aaatcgcaaa gaacgtgttt gtgcagaaca tttgaggaag 2040 tacaatgagg ccctacaaat taatgacaca attcgaatga tagatgcgta tactcatctt 2100 gaaactttct ataatgaaga gaaagataag aagtttgcag tcatagaaga tgatagtgat 2160 gagggtggtg atgatgagta ttgtgatggt gatgaagatg aggatgattt aaagaaacct 2220 ttgaaactgg atgaaacaga tagatttctc atgactttat tttttgaaaa caataaaatg 2280 ttgaaaaggc tggctgaaaa cccagaatat gaaaatgaaa agctgaccaa attaagaaat 2340 accataatgg agcaatatac taggactgag gaatcagcac gaggaataat ctttacaaaa 2400 acacgacaga gtgcatatgc gctttcccag tggattactg aaaatgaaaa atttgctgaa 2460 gtaggagtca aagcccacca tctgattgga gctggacaca gcagtgagtt caaacccatg 2520 acacagaatg aacaaaaaga agtcattagt aaatttcgca ctggaaaaat aaatctgctt 2580 atcgctacca cagtggcaga agaaggtctg gatattaaag aatgtaacat tgttatccgt 2640 tatggtctcg tcaccaatga aatagccatg gtccaggccc gtggtcgagc cagagctgat 2700 ggagcacct acgtcctggt tgctcacagt ggttcaggag ttatcgaaca tgagacagtt 2760 aatgatttcc gagagaagat gatgtataaa gctatacatt gtgttcaaaa tatgaaacca 2820 gaggagtatg ctcataagat tttggaatta cagatgcaaa gtataatgga aaagaaaatg 2880 aaaaccaaga gaaatattgc caagcattac aagaataacc catcactaat aactttcctt 2940 tgcaaaaact gcagtgtgct agcctgttct ggggaagata tccatgtaat tgagaaaatg 3000 catcacgtca atatgacccc agaattcaag gaactttaca ttgtaagaga aaacaaagca 3060 ctgcaaaaga agtgtgccga ctatcaaata aatggtgaaa tcatctgcaa atgtggccag 3120 gcttggggaa caatgatggt gcacaaaggc ttagatttgc cttgtctcaa aataaggaat 3180 tttgtagtgg ttttcaaaaa taattcaaca aagaaacaat acaaaaagtg ggtagaatta 3240 cctatcacat ttcccaatct tgactattca gaatgctgtt tatttagtga tgaggattag 3300 cacttgattg aagattcttt taaaatacta tcagttaaac atttaatatg attatgatta 3360 atgtattcat tatgctacag aactgacata agaatcaata aaatgattgt tttactctgc 3420 aaaaaaaaaa aaaa 3434 <210> 28 <211> 1876 <212> DNA <213> Homo sapiens <400> 28 ttacaccatt ggctgctgtt tagctccctt atataacact gtcttggggt ttaaacgtaa 60 ctgaaaatcc acaagacaga atagccagat ctcagaggag cctggctaag caaaaccctg 120 cagaacggct gcctaattta cagcaaccat gagtacaaat ggtgatgatc atcaggtcaa 180 ggatagtctg gagcaattga gatgtcactt tacatgggag ttatccattg atgacgatga 240 aatgcctgat ttagaaaaca gagtcttgga tcagattgaa ttcctagaca ccaaatacag 300 tgtgggaata cacaacctac tagcctatgt gaaacacctg aaaggccaga atgaggaagc 360 cctgaagagc ttaaaagaag ctgaaaactt aatgcaggaa gaacatgaca accaagcaaa 420 tgtgaggagt ctggtgacct ggggcaactt tgcctggatg tattaccaca tgggcagact 480 ggcagaagcc cagacttacc tggacaaggt ggagaacatt tgcaagaagc tttcaaatcc 540 cttccgctat agaatggagt gtccagaaat agactgtgag gaaggatggg ccttgctgaa 600 gtgtggagga aagaattatg aacgggccaa ggcctgcttt gaaaaggtgc ttgaagtgga 660 ccctgaaaac cctgaatcca gcgctgggta tgcgatctct gcctatcgcc tggatggctt 720 taaattagcc acaaaaaatc acaagccatt ttctttgctt cccctaaggc aggctgtccg 780 cttaaatcca gacaatggat atattaaggt tctccttgcc ctgaagcttc aggatgaagg 840 acaggaagct gaaggagaaa agtacattga agaagctcta gccaacatgt cctcacagac 900 ctatgtcttt cgatatgcag ccaagtttta ccgaagaaaa ggctctgtgg ataaagctct 960 tgagttatta aaaaaggcct tgcaggaaac acccacttct gtcttactgc atcaccagat 1020 agggctttgc tacaaggcac aaatgatcca aatcaaggag gctacaaaag ggcagcctag 1080 agggcagaac agagaaaagc tagacaaaat gataagatca gccatatttc attttgaatc 1140 tgcagtggaa aaaaagccca catttgaggt ggctcatcta gacctggcaa gaatgtatat 1200 agaagcaggc aatcacagaa aagctgaaga gaattttcaa aaattgttat gcatgaaacc 1260 agtggtagaa gaaacaatgc aagacataca tttccactat ggtcggtttc aggaatttca 1320 aaagaaatct gacgtcaatg caattatcca ttatttaaaa gctataaaaa tagaacaggc 1380 atcattaaca agggataaaa gtatcaattc tttgaagaaa ttggttttaa ggaaacttcg 1440 gagaaaggca ttagatctgg aaagcttgag cctccttggg ttcgtctaca aattggaagg 1500 aaatatgaat gaagccctgg agtactatga gcgggccctg agactggctg ctgactttga 1560 gaactctgtg agacaaggtc cttaggcacc cagatatcag ccactttcac atttcatttc 1620 attattatgct aacatttact aatcatcttt tctgcttact gttttcagaa acattataat 1680 tcactgtaat gatgtaattc ttgaataata aatctgacaa aatattagtt gtgttcaaca 1740 attagtgaaa cagaatgtgt gtatgcatgt aagaaagaga aatcatttgt atgagtgcta 1800 tgtagtagag aaaaaatgtt agttaacttt gtaggaaata aaacattgga cttacactaa 1860 aaaaaaaaaa aaaaaa 1876 <210> 29 <211> 1975 <212> DNA <213> Homo sapiens <400> 29 ggcagacagg aagacttctg aagaacaaat cagcctggtc accagctttt cggaacagca 60 gagacacaga gggcagtcat gagtgaggtc accaagaatt ccctggagaa aatccttcca 120 cagctgaaat gccatttcac ctggaactta ttcaaggaag acagtgtctc aagggatcta 180 gaagatagag tgtgtaacca gattgaattt ttaaacactg agttcaaagc tacaatgtac 240 aacttgttgg cctacataaa acacctagat ggtaacaacg aggcagccct ggaatgctta 300 cggcaagctg aagagttaat ccagcaagaa catgctgacc aagcagaaat cagaagtcta 360 gtcacttggg gaaactacgc ctgggtctac tatcacttgg gcagactctc agatgctcag 420 atttatgtag ataaggtgaa acaaacctgc aagaaatttt caaatccata cagtattgag 480 tattctgaac ttgactgtga ggaagggtgg acacaactga agtgtggaag aaatgaaagg 540 gcgaaggtgt gttttgagaa ggctctggaa gaaaagccca acaacccaga attctcctct 600 ggactggcaa ttgcgatgta ccatctggat aatcacccag agaaacagtt ctctactgat 660 gtttggaagc aggccattga gctgagtcct gataaccaat acgtcaaggt tctcttgggc 720 ctgaaactgc agaagatgaa taaagaagct gaaggagagc agtttgttga agaagccttg 780 gaaaagtctc cttgccaaac agatgtcctc cgcagtgcag ccaaatttta cagaagaaaa 840 ggtgacctag acaaagctat tgaactgttt caacgggtgt tggaatccac accaaacaat 900 ggctacctct atcaccagat tgggtgctgc tacaaggcaa aagtaagaca aatgcagaat 960 acaggagaat ctgaagctag tggaaataaa gagatgattg aagcactaaa gcaatatgct 1020 atggactatt cgaataaagc tcttgagaag ggactgaatc ctctgaatgc atactccgat 1080 ctcgctgagt tcctggagac ggaatgttat cagacaccat tcaataagga agtccctgat 1140 gctgaaaagc aacaatccca tcagcgctac tgcaaccttc agaaatataa tgggaagtct 1200 gaagacactg ctgtgcaaca tggtttagag ggtttgtcca taagcaaaaa atcaactgac 1260 aaggaagaga tcaaagacca accacagaat gtatccgaaa atctgcttcc acaaaatgca 1320 ccaaattatt ggtatcttca aggattaatt cataagcaga atggagatct gctgcaagca 1380 gccaaatgtt atgagaagga actgggccgc ctgctaaggg atgccccttc aggcataggc 1440 agtattttcc tgtcagcatc tgagcttgag gatggtagtg aggaaatggg ccagggcgca 1500 gtcagctcca gtcccagaga gctcctctct aactcagagc aactgaactg agacagagga 1560 ggaaaacaga gcatcagaag cctgcagtgg tggttgtgac gggtaggagg ataggaagac 1620 agggggcccc aacctgggat tgctgagcag ggaagctttg catgttgctc taaggtacat 1680 ttttaaagag ttgttttttg gccgggcgca gtggctcatg cctgtaatcc cagcactttg 1740 ggaggccgag gtgggcggat cacgaggtct ggagtttgag accatcctgg ctaacacagt 1800 gaaatcccgt ctctactaaa aatacaaaaa attagccagg cgtggtggct ggcacctgta 1860 gtcccagcta cttgggaggc tgaggcagga gaatggcgtg aacctggaag gaagaggttg 1920 cagtgagcca agattgcgcc ccctgcactc cagcctgggc ttcagagcaa gactc 1975 <210> 30 <211> 3906 <212> DNA <213> Homo sapiens <400> 30 ctggcgcgcg cacgcgcacg cgcacgccca ccgcgcggct tcccccgctc cccggtgctg 60 aggagagagc gatccgaggg actgcgccgc ccggacggcc tgcagagcgc tgccatcatg 120 agtgaaattc gtaaggacac cttgaaggcc attctgttgg agttagaatg tcattttaca 180 tggaatttac ttaaggaaga cattgatctg tttgaggtag aagatacaat tgggcaacag 240 cttgaatttc ttaccacaaa atctagactt gctctttata acctattggc ctatgtgaaa 300 cacctaaaag gccaaaataa agacgccctt gagtgcttgg aacaagcaga agaaataatc 360 cagcaagaac actcagacaa agaagaagta cgaagcctgg tcacttgggg aaactatgcc 420 tgggtgtatt atcacatgga ccagcttgaa gaagctcaga agtatacagg taagataggg 480 aatgtctgta agaaattgtc cagtccttct aactacaagt tggagtgtcc tgagactgac 540 tgtgagaaag gctgggcact cttgaaattt ggaggaaagt attatcaaaa ggctaaagcg 600 gcttttgaga aggctctgga agtggagcct gacaatccag aatttaacat cggctatgct 660 atcacagtgt atcggctgga tgattctgat agagaagggt ctgtaaagag cttttctctg 720 gggcctttga gaaaggctgt taccctgaac ccagataaca gctatattaa ggtttttctg 780 gcactgaagc ttcaagatgt acatgcagaa gctgaagggg aaaagtatat tgaagaaatc 840 ctggaccaaa tatcatccca gccttacgtc cttcgttatg cagccaagtt ctataggaga 900 aaaaattcct ggaacaaagc tctcgaactt ttaaaaaagg ccttggaggt gacaccaact 960 tcttctttcc tgcatcacca gatgggactt tgctacaggg cacaaatgat ccaaatcaag 1020 aaggccacac acaacagacc taaaggaaag gataaactaa aggttgatga gctgatttca 1080 tctgctatat ttcatttcaa agcagccatg gaacgagact ctatgtttgc atttgcctac 1140 acagacctgg ccaacatgta tgctgaagga ggccagtata gcaatgctga ggacattttc 1200 cggaaagctc ttcgtctgga gaacataacc gatgatcaca aacatcagat ccattaccac 1260 tatggccgct ttcaggaatt tcaccgtaaa tcagaaaata ctgccatcca tcattattta 1320 gaagccttaa aggtcaaaga cagatcaccc cttcgcacca aactgacaag tgctctgaag 1380 aaattgtcta ccaagagact ttgtcacaat gctttagatg tgcagagttt aagtgcccta 1440 gggtttgttt acaagctgga aggagaaaag aggcaagctg ctgagtacta tgagaaggca 1500 caaaagatag atccagaaaa tgcagaattc ctgactgctc tctgtgagct ccgactttcc 1560 atttaaatac atactctagg aaattagctc taagtttttc ccttcatttt gggttctcct 1620 gtttgttttt tttttattat tttaatccct tgtttattat agagctaata tttattgaat 1680 agttattgtg taccaagcat tgtgctaaat actttatatg cattatgatg aatcttgtgc 1740 ggttttcttt ctttttttct ttttaattaa aatactataa tccattgaga aatagcaata 1800 ttctagctat tgtaacttct aaaaatggta tggccattag atctgtgctt tttatctctg 1860 ctctttgaat ttctcatatt atatagtaaa tatattccta cgtaaacctt tgatacctag 1920 atcaggaata ctcttccagg agtacaaaat tacattattg atagttaagc tcttaattgt 1980 gtagcttgca aaagacagca ctttttagtt acagatgttt tgactttgat gaggatattt 2040 agctatcaat ctaatagtca cctaaaatat cttttttgtt ggaaaaaagt ttataataaa 2100 aaagtttgtc atctctagtg acttcaataa agaaaaaact agaagaggag aaaaaggatt 2160 tcctcaaatt ttaaatatgt aacttcaggg attcaatccc caaatgttta ttaagtagct 2220 agaaataatt atgtggaaaa aaatgaataa tggaaaatag tgagtctcaa attgtttttt 2280 tttaactaaa atctgcaatg aatctagatg caattaattt tattccttcc aactaaaatt 2340 acaatatttt taggttaaaa ttattgagat ataaagcagc cattgggaaa ttgggagaaa 2400 tgataaacaa atggaaaaag aagatgtccc taacctacac ccatagatta ccaaggtttc 2460 agtgtactag ttttgaatct gttctgaatg gagtttttat accctcaatt tctggccttt 2520 ggctatttta gcatttcaaa gtgacttcta tgaagctttt tttttaatgt gaaattttca 2580 gaatgttgtt tttttcatgt agatactcca ggaagagtta agcactgctt tcagttttaa 2640 tatccacctt gaggggtcgc tgcttgaggg ctcttatccc aggggacttt ttaattcgga 2700 tgttacttaa tgtggcttct ctaatgtagt ttctttgatt accgactaca caattatgta 2760 ccatcacagt attagtggaa aagtaccatg tgatttaatt ctccattcct ccaatgtaac 2820 tcttaaaatt attatgtatg tgtatgtgtt ttactttttg ttttttatca tctttaaaat 2880 ttctattatg gtttgattat tataaaaata atgaattctc actgtaaatt tcaaaaaaaa 2940 aattacaaaa gtatgtgaat ttaaaaatga gagcagtccc ctcaccctac cacagttcca 3000 caccctcaag gtaaacttat aacttataat ttgatatgta aacttccaga tcttttttct 3060 atgcgtaatc agacatacat atatactgca gtgtatctca cgtattaatt tttaaaaatc 3120 ttttgtttta cttaattctg tttttattat tattattatt ttgtttgatc tattaaggaa 3180 gaacaaggaa gggaatgatc tttactcaag aatttcagaa agtcagcact gaagtcctga 3240 cctatcagta gacacatttg tccctttcag atattttagg atattctagc aaagcaggcc 3300 atttctccca cctgaaagta cataacttct atcacttgcc acataattaa aagaactcac 3360 attaagcggt tactcagaca gttaatcata gaaaagatta tttgcttcat cagttcatag 3420 aaaagattat ttgcttcatc agttaacttg tttttataaa tcagggcctg tgttcataca 3480 cagaaggggc ctgagatttc tgcactttaa acaagctcct cctaggtgag gatgctgtgg 3540 ctgttctaat tacattttga gtagtaaggt ctacagcatt gttcctcaaa cttggctacg 3600 tattggaatc acctaaaaag ttaaaacaaa acatggatgt ctgggtcccg ccccatagag 3660 aatgacttaa ttggcatggg gtgcagtcca ggcatcatga tttttagatt tcccagttgg 3720 aacttgtgca gcaaagtttg ggagctactg atggacatgt gaaaagtaag tataaatgga 3780 ataaaattaa ttaggctaat aggcttaacc caggaaatcc taagttcctt gaatatccag 3840 tttgcatttg ggactcctca tcatatactt ggtatataat actctaataa aagctgcctg 3900 agttga 3906 <210> 31 <211> 678 <212> DNA <213> Homo sapiens <400> 31 aggaaaagga aactgttgag aaaccgaaac tactggggaa agggagggct cactgagaac 60 catcccagta acccgaccgc cgctggtctt cgctggacac catgaatcac actgtccaaa 120 ccttcttctc tcctgtcaac agtggccagc cccccaacta tgagatgctc aaggaggagc 180 acgaggtggc tgtgctgggg gcgccccaca accctgctcc cccgacgtcc accgtgatcc 240 acatccgcag cgagacctcc gtgcccgacc atgtcgtctg gtccctgttc aacaccctct 300 tcatgaaccc ctgctgcctg ggcttcatag cattcgccta ctccgtgaag tctagggaca 360 ggaagatggt tggcgacgtg accggggccc aggcctatgc ctccaccgcc aagtgcctga 420 acatctgggc cctgattctg ggcatcctca tgaccattct gctcatcgtc atcccagtgc 480 tgatcttcca ggcctatgga tagatcagga ggcatcactg aggccaggag ctctgcccat 540 gacctgtatc ccacgtactc caacttccat tcctcgccct gcccccggag ccgagtcctg 600 tatcagccct ttatcctcac acgcttttct acaatggcat tcaataaagt gcacgtgttt 660 ctggtgctaa aaaaaaaa 678 <210> 32 <211> 1240 <212> DNA <213> Homo sapiens <400> 32 cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt 60 ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg 120 gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct 180 cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt 240 aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat 300 tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa 360 ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa 420 gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg 480 actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa 540 gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg 600 tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa 660 tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat 720 caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata 780 tatgatattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga 840 ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa 900 cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat 960 aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag 1020 tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag 1080 catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc 1140 aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta 1200 agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1240 <210> 33 <211> 2308 <212> DNA <213> Homo sapiens <400> 33 gagagactgg atggacccac aagggtgaca gcccaggcgg accgatcttc ccatcccaca 60 tcctccggcg cgatgccaaa aagaggctga cggcaactgg gccttctgca gagaaagacc 120 tccgcttcac tgccccggct ggtcccaagg gtcaggaaga tggattcata cctgctgatg 180 tggggactgc tcacgttcat catggtgcct ggctgccagg cagagctctg tgacgatgac 240 ccgccagaga tcccacacgc cacattcaaa gccatggcct acaaggaagg aaccatgttg 300 aactgtgaat gcaagagagg tttccgcaga ataaaaagcg ggtcactcta tatgctctgt 360 acaggaaact ctagccactc gtcctgggac aaccaatgtc aatgcacaag ctctgccact 420 cggaacacaa cgaaacaagt gacacctcaa cctgaagaac agaaagaaag gaaaaccaca 480 gt; cctccaccat gggaaaatga agccacagag agaatttatc atttcgtggt ggggcagatg 600 gtttattatc agtgcgtcca gggatacagg gctctacaca gaggtcctgc tgagagcgtc 660 tgcaaaatga cccacgggaa gacaaggtgg acccagcccc agctcatatg cacaggtgaa 720 atggagacca gtcagtttcc aggtgaagag aagcctcagg caagccccga aggccgtcct 780 gagagtgaga cttcctgcct cgtcacaaca acagattttc aaatacagac agaaatggct 840 gcaaccatgg agacgtccat atttacaaca gagtaccagg tagcagtggc cggctgtgtt 900 ttcctgctga tcagcgtcct cctcctgagt gggctcacct ggcagcggag acagaggaag 960 agtagaagaa caatctagaa aaccaaaaga acaagaattt cttggtaaga agccgggaac 1020 agacaacaga agtcatgaag cccaagtgaa atcaaaggtg ctaaatggtc gcccaggaga 1080 catccgttgt gcttgcctgc gttttggaag ctctgaagtc acatcacagg acacggggca 1140 gtggcaacct tgtctctatg ccagctcagt cccatcagag agcgagcgct acccacttct 1200 aaatagcaat ttcgccgttg aagaggaagg gcaaaaccac tagaactctc catcttattt 1260 tcatgtatat gtgttcatta aagcatgaat ggtatggaac tctctccacc ctatatgtag 1320 tataaagaaa agtaggttta cattcatctc attccaactt cccagttcag gagtcccaag 1380 gaaagcccca gcactaacgt aaatacacaa cacacacact ctaccctata caactggaca 1440 ttgtctgcgt ggttcctttc tcagccgctt ctgactgctg attctcccgt tcacgttgcc 1500 taataaacat ccttcaagaa ctctgggctg ctacccagaa atcattttac ccttggctca 1560 atcctctaag ctaaccccct tctactgagc cttcagtctt gaatttctaa aaaacagagg 1620 ccatggcaga ataatctttg ggtaacttca aaacggggca gccaaaccca tgaggcaatg 1680 tcaggaacag aaggatgaat gaggtcccag gcagagaatc atacttagca aagttttacc 1740 tgtgcgttac taattggcct ctttaagagt tagtttcttt gggattgcta tgaatgatac 1800 cctgaatttg gcctgcacta atttgatgtt tacaggtgga cacacaaggt gcaaatcaat 1860 gcgtacgttt cctgagaagt gtctaaaaac accaaaaagg gatccgtaca ttcaatgttt 1920 atgcaaggaa ggaaagaaag aaggaagtga agagggagaa gggatggagg tcacactggt 1980 agaacgtaac cacggaaaag agcgcatcag gcctggcacg gtggctcagg cctataaccc 2040 cagctcccta ggagaccaag gcgggagcat ctcttgaggc caggagtttg agaccagcct 2100 gggcagcata gcaagacaca tccctacaaa aaattagaaa ttggctggat gtggtggcat 2160 acgcctgtag tcctagccac tcaggaggct gaggcaggag gattgcttga gcccaggagt 2220 tcgaggctgc agtcagtcat gatggcacca ctgcactcca gcctgggcaa cagagcaaga 2280 tcctgtcttt aaggaaaaaa agacaagg 2308 <210> 34 <211> 1125 <212> DNA <213> Homo sapiens <400> 34 ttctgccctc gagcccaccg ggaacgaaag agaagctcta tctcgcctcc aggagcccag 60 ctatgaactc cttctccaca agcgccttcg gtccagttgc cttctccctg gggctgctcc 120 tggtgttgcc tgctgccttc cctgccccag tacccccagg agaagattcc aaagatgtag 180 ccgccccaca cagacagcca ctcacctctt cagaacgaat tgacaaacaa attcggtaca 240 tcctcgacgg catctcagcc ctgagaaagg agacatgtaa caagagtaac atgtgtgaaa 300 gcagcaaaga ggcactggca gaaaacaacc tgaaccttcc aaagatggct gaaaaagatg 360 gatgcttcca atctggattc aatgaggaga cttgcctggt gaaaatcatc actggtcttt 420 tggagtttga ggtataccta gagtacctcc agaacagatt tgagagtagt gaggaacaag 480 ccagagctgt gcagatgagt acaaaagtcc tgatccagtt cctgcagaaa aaggcaaaga 540 atctagatgc aataaccacc cctgacccaa ccacaaatgc cagcctgctg acgaagctgc 600 aggcacagaa ccagtggctg caggacatga caactcatct cattctgcgc agctttaagg 660 agttcctgca gtccagcctg agggctcttc ggcaaatgta gcatgggcac ctcagattgt 720 tgttgttaat gggcattcct tcttctggtc agaaacctgt ccactgggca cagaacttat 780 gttgttctct atggagaact aaaagtatga gcgttaggac actattttaa ttatttttaa 840 tttattaata tttaaatatg tgaagctgag ttaatttatg taagtcatat ttatattttt 900 aagaagtacc acttgaaaca ttttatgtat tagttttgaa ataataatgg aaagtggcta 960 tgcagtttga atatcctttg tttcagagcc agatcatttc ttggaaagtg taggcttacc 1020 tcaaataaat ggctaactta tacatatttt taaagaaata tttatattgt atttatataa 1080 tgtataaatg gtttttatac caataaatgg cattttaaaa aattc 1125 <210> 35 <211> 1655 <212> DNA <213> Homo sapiens <400> 35 aatttctcac tgcccctgtg ataaactgtg gtcactggct gtggcagcaa ctattataag 60 atgctctgaa aactcttcag acactgaggg gcaccagagg agcagactac aagaatggca 120 cacgctatgg aaaactcctg gacaatcagt aaagagtacc atattgatga agaagtgggc 180 tttgctctgc caaatccaca ggaaaatcta cctgattttt ataatgactg gatgttcatt 240 gctaaacatc tgcctgatct catagagtct ggccagcttc gagaaagagt tgagaagtta 300 aacatgctca gcattgatca tctcacagac cacaagtcac agcgccttgc acgtctagtt 360 ctgggatgca tcaccatggc atatgtgtgg ggcaaaggtc atggagatgt ccgtaaggtc 420 ttgccaagaa atattgctgt tccttactgc caactctcca agaaactgga actgcctcct 480 attttggttt atgcagactg tgtcttggca aactggaaga aaaaggatcc taataagccc 540 ctgacttatg agaacatgga cgttttgttc tcatttcgtg atggagactg cagtaaagga 600 ttcttcctgg tctctctatt ggtggaaata gcagctgctt ctgcaatcaa agtaattcct 660 actgtattca aggcaatgca aatgcaagaa cgggacactt tgctaaaggc gctgttggaa 720 atagcttctt gcttggagaa agcccttcaa gtgtttcacc aaatccacga tcatgtgaac 780 ccaaaagcat ttttcagtgt tcttcgcata tatttgtctg gctggaaagg caacccccag 840 ctatcagacg gtctggtgta tgaagggttc tgggaagacc caaaggagtt tgcagggggc 900 agtgcaggcc aaagcagcgt ctttcagtgc tttgacgtcc tgctgggcat ccagcagact 960 gctggtggag gacatgctgc tcagttcctc caggacatga gaagatatat gccaccagct 1020 cacaggaact tcctgtgctc attagagtca aatccctcag tccgtgagtt tgtcctttca 1080 aaaggtgatg ctggcctgcg ggaagcttat gacgcctgtg tgaaagctct ggtctccctg 1140 aggagctacc atctgcaaat cgtgactaag tacatcctga ttcctgcaag ccagcagcca 1200 aaggagaata agacctctga agacccttca aaactggaag ccaaaggaac tggaggcact 1260 gatttaatga atttcctgaa gactgtaaga agtacaactg agaaatccct tttgaaggaa 1320 ggttaatgta acccaacaag agcacatttt atcatagcag agacatctgt atgcattcct 1380 gtcattaccc attgtaacag agccacaaac taatactatg caatgtttta ccaataatgc 1440 aatacaaaag acctcaaaat acctgtgcat ttcttgtagg aaaacaacaa aaggtaatta 1500 tgtgtaatta tactagaagt tttgtaatct gtatcttatc attggaataa aatgacattc 1560 aataaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 1655 <210> 36 <211> 633 <212> DNA <213> Homo sapiens <400> 36 cggctgagag gcagcgaact catctttgcc agtacaggag cttgtgccgt ggcccacagc 60 ccacagccca cagccatggg ctgggacctg acggtgaaga tgctggcggg caacgaattc 120 caggtgtccc tgagcagctc catgtcggtg tcagagctga aggcgcagat cacccagaag 180 ggcgctgcg gacagggtcc cccttgccag ccagggcctg ggccctggca gcacggtcct gctggtggtg 300 gacaaatgcg acgaacctct gagcatcctg gtgaggaata acaagggccg cagcagcacc 360 tacgaggtcc ggctgacgca gaccgtggcc cacctgaagc agcaagtgag cgggctggag 420 ggtgtgcagg acgacctgtt ctggctgacc ttcgagggga agcccctgga ggaccagctc 480 ccgctggggg agtacggcct caagcccctg agcaccgtgt tcatgaatct gcgcctgcgg 540 ggaggcggca cagagcctgg cgggcggagc taagggcctc caccagcatc cgagcaggat 600 caagggccgg aaataaaggc tgttgtaaga gaa 633 <210> 37 <211> 587 <212> DNA <213> Homo sapiens <400> 37 taaatctttt ctgcttactg aaaaggaaga gtctgatgat tagttactga tcctctttgc 60 atttgtaaag ctttggagat attgaatcat gttaccattt ctgttttttt ccaccctgtt 120 ttcttccata tttactgaag ctcagaagca gtattgggtc tgcaactcat ccgatgcaag 180 tatttcatac acctactgtg ataaaatgca atacccaatt tcaattaatg ttaacccctg 240 tatagaattg aaaggatcca aaggattatt gcacattttc tacattccaa ggagagattt 300 aaagcaatta tatttcaatc tctatataac tgtcaacacc atgaatcttc caaagcgcaa 360 agaagttatt tgccgaggat ctgatgacga ttactctttt tgcagagctc tgaagggaga 420 gactgtgaat acaacaatat cattctcctt caagggaata aaattttcta agggaaaata 480 caaatgtgtt gttgaagcta tttctgggag cccagaagaa atgctctttt gcttggagtt 540 tgtcatccta caccaaccta attcaaatta gaataaattg agtattt 587 <210> 38 <211> 2787 <212> DNA <213> Homo sapiens <400> 38 agagcggagg ccgcactcca gcactgcgca gggaccgcct tggaccgcag ttgccggcca 60 ggaatcccag tgtcacggtg gacacgcctc cctcgcgccc ttgccgccca cctgctcacc 120 cagctcaggg gctttggaat tctgtggcca cactgcgagg agatcggttc tgggtcggag 180 gctacaggaa gactcccact ccctgaaatc tggagtgaag aacgccgcca tccagccacc 240 attccaagga ggtgcaggag aacagctctg tgataccatt taacttgttg acattacttt 300 tatttgaagg aacgtatatt agagcttact ttgcaaagaa ggaagatggt tgtttccgaa 360 gtggacatcg caaaagctga tccagctgct gcatcccacc ctctattact gaatggagat 420 gctactgtgg cccagaaaaa tccaggctcg gtggctgaga acaacctgtg cagccagtat 480 gaggagaagg tgcgcccctg catcgacctc attgactccc tgcgggctct aggtgtggag 540 caggacctgg ccctgccagc catcgccgtc atcggggacc agagctcggg caagagctcc 600 gtgttggagg cactgtcagg agttgccctt cccagaggca gcgggatcgt gaccagatgc 660 ccgctggtgc tgaaactgaa gaaacttgtg aacgaagata agtggagagg caaggtcagt 720 taccaggact acgagattga gatttcggat gcttcagagg tagaaaagga aattaataaa 780 gcccagaatg ccatcgccgg ggaaggaatg ggaatcagtc atgagctaat caccctggag 840 atcagctccc gagatgtccc ggatctgact ctaatagacc ttcctggcat aaccagagtg 900 gctgtgggca atcagcctgc tgacattggg tataagatca agacactcat caagaagtac 960 atccagaggc aggagacaat cagcctggtg gtggtcccca gtaatgtgga catcgccacc 1020 acagaggctc tcagcatggc ccaggaggtg gaccccgagg gagacaggac catcggaatc 1080 ttgacgaagc ctgatctggt ggacaaagga actgaagaca aggttgtgga cgtggtgcgg 1140 aacctcgtgt tccacctgaa gaagggttac atgattgtca agtgccgggg ccagcaggag 1200 atccaggacc agctgagcct gtccgaagcc ctgcagagag agaagatctt ctttgagaac 1260 ccccatatt tcagggatct gctggaggaa ggaaaggcca cggttccctg cctggcagaa 1320 aaacttacca gcgagctcat cacacatatc tgtaaatctc tgcccctgtt agaaaatcaa 1380 atcaaggaga ctcaccagag aataacagag gagctacaaa agtatggtgt cgacataccg 1440 gaagacgaaa atgaaaaaat gttcttcctg atagataaaa ttaatgcctt taatcaggac 1500 atcactgctc tcatgcaagg agaggaaact gtaggggagg aagacattcg gctgtttacc 1560 agactccgac acgagttcca caaatggagt acaataattg aaaacaattt tcaagaaggc 1620 cataaaattt tgagtagaaa aatccagaaa tttgaaaatc agtatcgtgg tagagagctg 1680 ccaggctttg tgaattacag gacatttgag acaatcgtga aacagcaaat caaggcactg 1740 gaagagccgg ctgtggatat gctacacacc gtgacggata tggtccggct tgctttcaca 1800 gatgtttcga taaaaaattt tgaagagttt tttaacctcc acagaaccgc caagtccaaa 1860 attgaagaca ttagagcaga acaagagaga gaaggtgaga agctgatccg cctccacttc 1920 cagatggaac agattgtcta ctgccaggac caggtataca ggggtgcatt gcagaaggtc 1980 agagagaagg agctggaaga agaaaagaag aagaaatcct gggattttgg ggctttccag 2040 tccagctcgg caacagactc ttccatggag gagatctttc agcacctgat ggcctatcac 2100 caggaggcca gcaagcgcat ctccagccac atccctttga tcatccagtt cttcatgctc 2160 cagacgtacg gccagcagct tcagaaggcc atgctgcagc tcctgcagga caaggacacc 2220 tacagctggc tcctgaagga gcggagcgac accagcgaca agcggaagtt cctgaaggag 2280 cggcttgcac ggctgacgca ggctcggcgc cggcttgccc agttccccgg ttaaccacac 2340 tctgtccagc cccgtagacg tgcacgcaca ctgtctgccc ccgttcccgg gtagccactg 2400 gactgacgac ttgagtgctc agtagtcaga ctggatagtc cgtctctgct tatccgttag 2460 ccgtggtgat ttagcaggaa gctgtgagag cagtttggtt tctagcatga agacagagcc 2520 ccaccctcag atgcacatga gctggcggga ttgaaggatg ctgtcttcgt actgggaaag 2580 ggattttcag ccctcagaat cgctccacct tgcagctctc cccttctctg tattcctaga 2640 aactgacaca tgctgaacat cacagcttat ttcctcattt ttataatgtc ccttcacaaa 2700 cccagtgttt taggagcatg agtgccgtgt gtgtgcgtcc tgtcggagcc ctgtctcctc 2760 tctctgtaat aaactcattt ctagcag 2787 <210> 39 <211> 2961 <212> DNA <213> Homo sapiens <400> 39 aagagatgat ttctccatcc tgaacgtgca gcgagcttgt caggaagatc ggaggtgcca 60 agtagcagag aaagcatccc ccagctctga cagggagaca gcacatgtct aaggcccaca 120 agccttggcc ctaccggagg agaagtcaat tttcttctcg aaaatacctg aaaaaagaaa 180 tgaattcctt ccagcaacag ccaccgccat tcggcacagt gccaccacaa atgatgtttc 240 ctccaaactg gcagggggca gagaaggacg ctgctttcct cgccaaggac ttcaactttc 300 tcactttgaa caatcagcca ccaccaggaa acaggagcca accaagggca atggggcccg 360 agaacaacct gtacagccag tacgagcaga aggtgcgccc ctgcattgac ctcatcgact 420 ccctgcgggc tctgggtgtg gagcaggacc tggccctgcc agccatcgcc gtcatcgggg 480 accagagctc gggcaagagc tctgtgctgg aggcactgtc aggagtcgcg cttcccagag 540 gcagcggaat cgtaaccagg tgtccgctgg tgctgaaact gaaaaagcag ccctgtgagg 600 catgggccgg aaggatcagc taccggaaca ccgagctaga gcttcaggac cctggccagg 660 tggagaaaga gatacacaaa gcccagaacg tcatggccgg gaatggccgg ggcatcagcc 720 atgagctcat cagcctggag atcacctccc ctgaggttcc agacctgacc atcattgacc 780 ttcccggcat caccagggtg gctgtggaca accagccccg agacatcgga ctgcagatca 840 aggctctcat caagaagtac atccagaggc agcagacgat caacttggtg gtggttccct 900 gtaacgtgga cattgccacc acggaggcgc tgagcatggc ccatgaggtg gacccggaag 960 gggacaggac catcggtatc ctgaccaaac cagatctaat ggacaggggc actgagaaaa 1020 gcgtcatgaa tgtggtgcgg aacctcacgt accccctcaa gaagggctac atgattgtga 1080 agtgccgggg ccagcaggag atcacaaaca ggctgagctt ggcagaggca accaagaaag 1140 aaattacatt ctttcaaaca catccatatt tcagagttct cctggaggag gggtcagcca 1200 cggttccccg actggcagaa agacttacca ctgaactcat catgcatatc caaaaatcgc 1260 tcccgttgtt agaaggacaa ataagggaga gccaccagaa ggcgaccgag gagctgcggc 1320 gttgcggggc tgacatcccc agccaggagg ccgacaagat gttctttcta attgagaaaa 1380 tcaagatgtt taatcaggac atcgaaaagt tagtagaagg agaagaagtt gtaagggaga 1440 atgagacccg tttatacaac aaaatcagag aggattttaa aaactgggta ggcatacttg 1500 caactaatac ccaaaaagtt aaaaatatta tccacgaaga agttgaaaaa tatgaaaagc 1560 agtatcgagg caaggagctt ctgggatttg tcaactacaa gacatttgag atcatcgtgc 1620 atcagtacat ccagcagctg gtggagcccg cccttagcat gctccagaaa gccatggaaa 1680 ttatccagca agctttcatt aacgtggcca aaaaacattt tggcgaattt ttcaacctta 1740 accaaactgt tcagagcacg attgaagaca taaaagtgaa acacacagca aaggcagaaa 1800 acatgatcca acttcagttc agaatggagc agatggtttt ttgtcaagat cagatttaca 1860 gtgttgttct gaagaaagtc cgagaagaga tttttaaccc tctggggacg ccttcacaga 1920 atatgaagtt gaactctcat tttcccagta atgagtcttc ggtttcctcc tttactgaaa 1980 taggcatcca cctgaatgcc tacttcttgg aaaccagcaa acgtctcgcc aaccagatcc 2040 catttataat tcagtatttt atgctccgag agaatggtga ctccttgcag aaagccatga 2100 tgcagatact acaggaaaaa aatcgctatt cctggctgct tcaagagcag agtgagaccg 2160 ctaccaagag aagaatcctt aaggagagaa tttaccggct cactcaggcg cgacacgcac 2220 tctgtcaatt ctccagcaaa gagatccact gaagggcggc gatgcctgtg gttgttttct 2280 tgtgcgtact cattcattct aaggggagtc ggtgcaggat gccgcttctg ctttggggcc 2340 gt; atcaggggtc cacacaggct cagctctctc caccacccag ctcttccctg accttcacga 2460 agggatggct ctccagtcct tgggtcccgt agcacacagt tacagtgtcc taagatactg 2520 ctatcattct tcgctaattt gtatttgtat tcccttcccc ctacaagatt atgagacccc 2580 agagggggaa ggtctgggtc aaattcttct tttgtatgtc cagtctcctg cacagcacct 2640 gcagcattgt aactgcttaa taaatgacat ctcactgaac gaatgagtgc tgtgtaagtg 2700 atggagatac ctgaggctat tgctcaagcc caggccttgg acatttagtg actgttagcc 2760 ggtccctttc agatccagtg gccatgcccc ctgcttccca tggttcactg tcattgtgtt 2820 tcccagcctc tccactcccc cgccagaaag gagcctgagt gattctcttt tcttcttgtt 2880 tccctgatta tgatgagctt ccattgttct gttaagtctt gaagaggaat ttaataaagc 2940 aaagaaactt tttaaaaacg t 2961 <210> 40 <211> 1575 <212> DNA <213> Homo sapiens <400> 40 tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag 60 caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag 120 aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg 180 tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg 240 cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg 300 caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct 360 caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca 420 gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg 480 ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt 540 ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc 600 taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga 660 gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct 720 caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa 780 gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat 840 gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta 900 ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa 960 gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac 1020 aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc 1080 ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct 1140 gctgacccag cacactccag gcagcatcca ccccacaggc agaagaggac tggacctgca 1200 ccatcctctg aatgccagtg catcttgggg gaaagggctc cagtgttatc tggaccagtt 1260 ccttcatttt caggtgggac tcttgatcca gagaggacaa agctcctcag tgagctggtg 1320 tataatccag gacagaaccc aggtctcctg actcctggcc ttctatgccc tctatcctat 1380 catagataac attctccaca gcctcacttc attccaccta ttctctgaaa atattccctg 1440 agagagaaca gagagattta gataagagaa tgaaattcca gccttgactt tcttctgtgc 1500 acctgatggg agggtaatgt ctaatgtatt atcaataaca ataaaaataa agcaaatacc 1560 atttaaaaaa aaaaa 1575 <210> 41 <211> 3539 <212> DNA <213> Homo sapiens <400> 41 caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt 60 tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg 120 ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc 180 agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga 240 tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg 300 tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg 360 atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc 420 aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt 480 tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa 540 aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata 600 atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc 660 ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg 720 gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa 780 tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg 840 aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc 900 tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg 960 agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc 1020 cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag 1080 aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga 1140 atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg 1200 agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc 1260 gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg 1320 gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt 1380 tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg 1440 aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct 1500 ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc 1560 tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt 1620 ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg 1680 acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct 1740 cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg 1800 aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca 1860 tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga 1920 cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca 1980 actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg 2040 tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc 2100 atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg 2160 gaaacccaat accaccttgg aaagtgccga caatgcagac accaggaagt tgtggagcta 2220 ggatccatcc tattgtcaat gagatgttct catccagaag ccatagaatc ctgaataata 2280 attctaaaag aaacttctag agatcatctg gcaatcgctt ttaaagactc ggctcaccgt 2340 gagaaagagt cactcacatc cattcttccc ttgatggtcc ctattcctcc ttcccttgct 2400 tcttggactt cttgaaatca atcaagactg caaacccttt cataaagtct tgccttgctg 2460 aactccctct ctgcaggcag cctgccttta aaaatagttg ctgtcatcca ctttatgtgc 2520 atcttatttc tgtcaacttg tatttttttt cttgtatttt tccaattagc tcctcctttt 2580 tccttccagt ctaaaaaagg aatcctctgt gtcttcaaag caaagctctt tactttcccc 2640 ttggttctca taactctgtg atcttgctct cggtgcttcc aactcatcca cgtcctgtct 2700 gtttcctctg tatacaaaac cctttctgcc cctgctgaca cagacatcct ctatgccagc 2760 agccagccaa ccctttcatt agaacttcaa gctctccaaa ggctcagatt ataactgttg 2820 tcatatttat atgaggctgt tgtcttttcc ttctgagcct gcctttctcc cccccaccca 2880 ggagtatcct cttgccaaat caaaagactt tttccttggg ctttagcctt aaagatactt 2940 gaaggtctag gtgctttaac ctcacatacc ctcacttaaa cttttatcac tgttgcatat 3000 accagttgtg atacaataaa gaatgtatct ggattttgtg cctagttcct agcacacagc 3060 ttcaaaaatt ctagagtttc ctgataggag tgtcttttgt attcataaca agcccttttc 3120 acccatgcct gggtttatgc taacaaggtt acccatggtg ggcccttagt ttcaaggaag 3180 gagttggcca agccagaaag accaagcatg tggttaaagc attggaattt tcagccccat 3240 cccaccccca atctccaagg aggtgatggg gctggaaatt gagttcaatt ttaacatggc 3300 cagtgattta agcaatgctg cctatgtaaa gaaaccccaa taaaaactct ggacagtgag 3360 gcttggggag cttcctgatt ggcagacatt ccaatgtact aggaaggtag cgcatcttga 3420 ttccacaggg acaaaggctc ctgagctctg ggcccttcca gtgcttgcca ccctacatac 3480 tctttgtctg gctcttcatt tgtattcttt ataataaaat ggtgattgta agtagagca 3539 <210> 42 <211> 6646 <212> DNA <213> Homo sapiens <400> 42 gttcggagag ccgggcggga aaacgaaacc agaaatccga aggccgcgcc agagccctgc 60 ttccccttgc acctgcgccg ggcggccatg gacttgtaca gcaccccggc cgctgcgctg 120 gacaggttcg tggccagaag gctgcagccg cggaaggagt tcgtagagaa ggcgcggcgc 180 gctctgggcg ccctggccgc tgccctgagg gagcgcgggg gccgcctcgg tgctgctgcc 240 ccgcgggtgc tgaaaactgt caagggaggc tcctcgggcc ggggcacagc tctcaagggt 300 ggctgtgatt ctgaacttgt catcttcctc gactgcttca agagctatgt ggaccagagg 360 gcccgccgtg cagagatcct cagtgagatg cgggcatcgc tggaatcctg gtggcagaac 420 ccagtccctg gtctgagact cacgtttcct gagcagagcg tgcctggggc cctgcagttc 480 cgcctgacat ccgtagatct tgaggactgg atggatgtta gcctggtgcc tgccttcaat 540 gtcctgggtc aggccggctc cggcgtcaaa cccaagccac aagtctactc taccctcctc 600 aacagtggct gccaaggggg cgagcatgcg gcctgcttca cagagctgcg gaggaacttt 660 gtgaacattc gcccagccaa gttgaagaac ctaatcttgc tggtgaagca ctggtaccac 720 caggtgtgcc tacaggggtt gtggaaggag acgctgcccc cggtctatgc cctggaattg 780 ctgaccatct tcgcctggga gcagggctgt aagaaggatg ctttcagcct agccgaaggc 840 ctccgaactg tcctgggcct gatccaacag catcagcacc tgtgtgtttt ctggactgtc 900 aactatggct tcgaggaccc tgcagttggg cagttcttgc agcggcagct taagagaccc 960 aggcctgtga tcctggaccc agctgacccc acatgggacc tggggaatgg ggcagcctgg 1020 cactgggatt tgctagccca ggaggcagca tcctgctatg accacccatg ctttctgagg 1080 gggatggggg acccagtgca gtcttggaag gggccgggcc ttccacgtgc tggatgctca 1140 ggtttgggcc accccatcca gctagaccct aaccagaaga cccctgaaaa cagcaagagc 1200 ctcaatgctg tgtacccaag agcagggagc aaacctccct catgcccagc tcctggcccc 1260 actggggcag ccagcatcgt cccctctgtg ccgggaatgg ccttggacct gtctcagatc 1320 cccaccaagg agctggaccg cttcatccag gaccacctga agccgagccc ccagttccag 1380 gagcaggtga aaaaggccat cgacatcatc ttgcgctgcc tccatgagaa ctgtgttcac 1440 aaggcctcaa gagtcagtaa agggggctc tttggccggg gcacagacct aagggatggc 1500 tgtgatgttg aactcatcat cttcctcaac tgcttcacgg actacaagga ccaggggccc 1560 cgccgcgcag agatccttga tgagatgcga gcgcagctag aatcctggtg gcaggaccag 1620 gtgcccagcc tgagccttca gtttcctgag cagaatgtgc ctgaggctct gcagttccag 1680 ctggtgtcca cagccctgaa gagctggacg gatgttagcc tgctgcctgc cttcgatgct 1740 gtggggcagc tcagttctgg caccaaacca aatccccagg tctactcgag gctcctcacc 1800 agtggctgcc aggagggcga gcataaggcc tgcttcgcag agctgcggag gaacttcatg 1860 aacattcgcc ctgtcaagct gaagaacctg attctgctgg tgaagcactg gtaccgccag 1920 gttgcggctc agaacaaagg aaaaggacca gcccctgcct ctctgccccc agcctatgcc 1980 ctggagctcc tcaccatctt tgcctgggag cagggctgca ggcaggattg tttcaacatg 2040 gcccaaggct tccggacggt gctggggctc gtgcaacagc atcagcagct ctgtgtctac 2100 tggacggtca actatagcac tgaggaccca gccatgagaa tgcaccttct tggccagctt 2160 cgaaaaccca gacccctggt cctggacccc gctgatccca cctggaacgt gggccacggt 2220 agctgggagc tgttggccca ggaagcagca gcgctgggga tgcaggcctg ctttctgagt 2280 agagacggga catctgtgca gccctgggat gtgatgccag ccctccttta ccaaacccca 2340 gctggggacc ttgacaagtt catcagtgaa tttctccagc ccaaccgcca gttcctggcc 2400 caggtgaaca aggccgttga taccatctgt tcatttttga aggaaaactg cttccggaat 2460 tctcccatca aagtgatcaa ggtggtcaag ggtggctctt cagccaaagg cacagctctg 2520 cgaggccgct cagatgccga cctcgtggtg ttcctcagct gcttcagcca gttcactgag 2580 cagggcaaca agcgggccga gatcatctcc gagatccgag cccagctgga ggcatgtcaa 2640 caggagcggc agttcgaggt caagtttgaa gtctccaaat gggagaatcc ccgcgtgctg 2700 agcttctcac tgacatccca gacgatgctg gaccagagtg tggactttga tgtgctgcca 2760 gcctttgacg ccctaggcca gctggtctct ggctccaggc ccagctctca agtctacgtc 2820 gacctcatcc acagctacag caatgcgggc gagtactcca cctgcttcac agagctacaa 2880 cgggacttca tcatctctcg ccctaccaag ctgaagagcc tgatccggct ggtgaagcac 2940 tggtaccagc agtgtaccaa gatctccaag gggagaggct ccctaccccc acagcacggg 3000 ctggaactcc tgactgtgta tgcctgggag cagggcggga aggactccca gttcaacatg 3060 gctgagggct tccgcacggt cctggagctg gtcacccagt accgccagct ctgtatctac 3120 tggaccatca actacaacgc caaggacaag actgttggag acttcctgaa acagcagctt 3180 cagaagccca ggcctatcat cctggatccg gctgacccga caggcaacct gggccacaat 3240 gcccgctggg acctgctggc caaggaagct gcagcctgca catctgccct gtgctgcatg 3300 ggacggaatg gcatccccat ccagccatgg ccagtgaagg ctgctgtgtg aagttgagaa 3360 aatcagcggt cctactggat gaagagaaga tggacaccag ccctcagcat gaggaaattc 3420 agggtcccct accagatgag agagattgtg tacatgtgtg tgtgagcaca tgtgtgcatg 3480 tgtgtgcaca cgtgtgcatg tgtgtgtttt agtgaatctg ctctcccagc tcacacactc 3540 ccctgcctcc catggcttac acactaggat ccagactcca tggtttgaca ccagcctgcg 3600 tttgcagctt ctctgtcact tccatgactc tatcctcata ccaccactgc tgcttcccac 3660 ccagctgaga atgccccctc ctccctgact cctctctgcc catgcaaatt agctcacatc 3720 tttcctcctg ctgcaatcca tcccttcctc ccattggcct ctccttgcca aatctaaata 3780 gtttatatag ggatggcaga gagttcccat ctcatctgtc agccacagtc atttggtact 3840 ggctacctgg agccttatct tctgaagggt tttaaagaat ggccaattag ctgagaagaa 3900 ttatctaatc aattagtgat gtctgccatg gatgcagtag aggaaagtgg tggtacaagt 3960 gccatgattg attagcaatg tctgcactgg atacggaaaa aagaaggtgc ttgcaggttt 4020 acagtgtata tgtgggctat tgaagagccc tctgagctcg gttgctagca ggagagcatg 4080 cccatattgg cttactttgt ctgccacaga cacagacaga gggagttggg acatgcatgc 4140 tatggggacc ctcttgttgg acacctaatt ggatgcctct tcatgagagg cctccttttc 4200 ttcacctttt atgctgcact cctcccctag tttacacatc ttgatgctgt ggctcagttt 4260 gccttcctga atttttattg ggtccctgtt ttctctccta acatgctgag attctgcatc 4320 cccacagcct aaactgagcc agtggccaaa caaccgtgct cagcctgttt ctctctgccc 4380 tctagagcaa ggcccaccag gtccatccag gaggctctcc tgacctcaag tccaacaaca 4440 gtgtccacac tagtcaaggt tcagcccaga aaacagaaag cactctagga atcttaggca 4500 gaaagggatt ttatctaaat cactggaaag gctggaggag cagaaggcag aggccaccac 4560 tggactattg gtttcaatat tagaccactg tagccgaatc agaggccaga gagcagccac 4620 tgctactgct aatgccacca ctacccctgc catcactgcc ccacatggac aaaactggag 4680 tcgagaccta ggttagattc ctgcaaccac aaacatccat cagggatggc cagctgccag 4740 agctgcggga agacggatcc cacctccctt tcttagcaga atctaaatta cagccagacc 4800 tctggctgca gaggagtctg agacatgtat gattgaatgg gtgccaagtg ccagggggcg 4860 gagtccccag cagatgcatc ctggccatct gttgcgtgga tgagggagtg ggtctatctc 4920 agaggaagga acaggaaaca aagaaaggaa gccactgaac atcccttctc tgctccacag 4980 gagtgcctta gacagcctga ctctccacaa accactgtta aaacttacct gctaggaatg 5040 ctagattgaa tgggatggga agagccttcc ctcattattg tcattcttgg agagaggtga 5100 gcaaccaagg gaagctcctc tgattcacct agaacctgtt ctctgccgtc tttggctcag 5160 cctacagaga ctagagtagg tgaagggaca gaggacaggg cttctaatac ctgtgccata 5220 ttgacagcct ccatccctgt cccccatctt ggtgctgaac caacgctaag ggcaccttct 5280 tagactcacc tcatcgatac tgcctggtaa tccaaagcta gaactctcag gaccccaaac 5340 tccacctctt ggattggccc tggctgctgc cacacacata tccaagagct cagggccagt 5400 tctggtgggc agcagagacc tgctctgcca agttgtccag cagcagagtg gccctggcct 5460 gggcatcaca agccagtgat gctcctggga agaccaggtg gcaggtcgca gttgggtacc 5520 ttccattccc accacacaga ctctgggcct ccccgcaaaa tggctccaga attagagtaa 5580 ttatgagatg gtgggaacca gagcaactca ggtgcatgat acaaggagag gttgtcatct 5640 gggtagggca gagaggaggg cttgctcatc tgaacagggg tgtatttcat tccaggccct 5700 cagtctttgg caatggccac cctggtgttg gcatattggc cccactgtaa cttttggggg 5760 cttcccggtc tagccacacc ctcggatgga aagacttgac tgcataaaga tgtcagttct 5820 ccctgagttg attgataggc ttaatggtca ccctaaaaac acccacatat gcttttcgat 5880 ggaaccaggt aagttgacgc taaagttctt atggaaaaat acacacgcaa tagctgagaa 5940 aacacaggga aagaagagtt ctgagcaggg cctagtctta gccaatatta aaacatacta 6000 tgaagcctct gatacttaaa cagcatggcg ctggtacgta aatagaccaa tgcagttagg 6060 tggctctttc caagactctg gggaaaaaag tagtaaaaag ctaaatgcaa tcaatcagca 6120 attgaaagct aagtgagaga gccagagggc ctccttggtg gtaaaagagg gttgcatttc 6180 ttgcagccag aaggcagaga aagtgaagac caagtccaga actgaatcct aagaaatgca 6240 ggactgcaaa gaaattggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttaattttt 6300 aaaaagtttt tattgagata caagtcaata ccataaagct ctcacccttc taaagtgtac 6360 aattcagtgg tgtgagtata ttcataagat ttatacttgg tgtctattca taagacttat 6420 atccagcata ttcataacta gagccatatc acagatgcat tcatcataat aattccagac 6480 attttcatca ccctaaaagg aaaccctgaa acccattagc agtcattccc cattcctcca 6540 acccattctc tccctaatcc ctagaaacca ccaatctgct gtgtatttca tctattgcca 6600 acatttcata taaatggcat catacaaaaa aaaaaaaaaaaaaaa 6646 <210> 43 <211> 1584 <212> DNA <213> Homo sapiens <400> 43 acagagatgg cactgatgca ggaactgtat agcacaccag cctccaggct ggactccttc 60 gtggctcagt ggctgcagcc ccaccgggag tggaaggaag aggtgctaga cgctgtgcgg 120 accgtggagg agtttctgag gcaggagcat ttccagggga agcgtgggct ggaccaggat 180 gtgcgggtgc tgaaggtagt caaggtgggc tccttcggga atggcacggt tctcaggagc 240 accagagagg tggagctggt ggcgtttctg agctgtttcc acagcttcca ggaggcagcc 300 aagcatcaca aagatgttct gaggctgata tggaaaacca tgtggcaaag ccaggacctg 360 ctggacctcg ggctcgagga cctgaggatg gagcagagag tccccgatgc tctcgtcttc 420 accatccaga ccagggggac tgcggagccc atcacggtca ccattgtgcc tgcctacaga 480 gccctggggc cttctcttcc caactcccag ccaccccctg aggtctatgt gagcctgatc 540 aaggcctgcg gtggtcctgg aaatttctgc ccatccttca gcgagctgca gagaaatttc 600 gtgaaacatc ggccaactaa gctgaagagc ctcctgcgcc tggtgaaaca ctggtaccag 660 caggcccatc atcctggatc cggccgaccc caccctcaac gtggcagaag ggtacagatg 720 ggacatcgtt gctcagaggg cctcccagtg cctgaaacag gactgttgct atgacaacag 780 ggagaacccc atctccagct ggaacgtgaa gagggcacga gacatccact tgacagtgga 840 gcagaggggt tacccagatt tcaacctcat cgtgaaccct tatgagccca taaggaaggt 900 taaagagaaa atccggagga ccaggggcta ctctggcctg cagcgtctgt ccttccaggt 960 tcctggcagt gagaggcagc ttctcagcag caggtgctcc ttagccaaat atgggatctt 1020 ctcccacact cacatctatc tgctggagac catcccctcc gagatccagg tcttcgtgaa 1080 gaatcctgat ggtgggagct acgcctatgc catcaacccc aacagcttca tcctgggtct 1140 gaagcagcag attgaagacc agcaggggct tcctaaaaag cagcagcagc tggaattcca 1200 aggccaagtc ctgcaggact ggttgggtct ggggatctat ggcatccaag acagtgacac 1260 tctcatcctc tcgaagaaga aaggagaggc tctgtttcca gccagttagt tttctctggg 1320 agacttctct gtacatttct gccatgtact ccagaactca tcctgtcaat cactctgtcc 1380 cattgtctac tgggaaggtc ccaggtcttc accagtttta caatgagtta tcccaggcca 1440 gacgtggtag ctcacacctg taatcccaga actttgggag gccgaggtgg gaggagcgct 1500 tgagccgagg agttcaagac cagcctgggt atcacaggga gaccccgtct ctacaaaata 1560 aaaaaataat tcactgggaa aaaa 1584 <210> 44 <211> 1403 <212> DNA <213> Homo sapiens <400> 44 gcctgtctgc attctactat ataaagcagc agagacgttg actagcgcat atttgctaag 60 agcaccatgc gcgcagcagc catctccact ccaaagttag acaaaatgcc aggaatgttc 120 ttctctgcta acccaaagga attgaaagga accactcatt cacttctaga cgacaaaatg 180 caaaaaagga ggccaaagac ttttggaatg gatatgaaag catacctgag atctatgatc 240 ccacatctgg aatctggaat gaaatcttcc aagtccaagg atgtactttc tgctgctgaa 300 gtaatgcaat ggtctcaatc tctggaaaaa cttcttgcca accaaactgg tcaaaatgtc 360 tttggaagtt tcctaaagtc tgaattcagt gaggagaata ttgagttctg gctggcttgt 420 gaagactata agaaaacaga gtctgatctt ttgccctgta aagcagaaga gatatataaa 480 gcatttgtgc attcagatgc tgctaaacaa atcaatattg acttccgcac tcgagaatct 540 acagccaaga agattaaagc accaaccccc acgtgttttg atgaagcaca aaaagtcata 600 tatactctta tggaaaagga ctcttatccc aggttcctca aatcagatat ttacttaaat 660 cttctaaatg acctgcaggc taatagccta aagtgactgg tccctggctg aagggaatta 720 acagatagta tcaagcgcag aaggaatgtg ccagtatggc tccctgggtg aacagcttgg 780 ccttttttgg gtgtcttgac aggccaagaa gaacaaatga ctcagaatgg attaacatga 840 aagttatcca ggcgcagagt tgaagaagca taagcaagac aaaaacagag agaccgcaga 900 aggaggaaga tactgtggta ctgtcataaa aaacagtgga gctctgtatt agaaagcccc 960 tcagaactgg gaaggccagg taactctagt tacacagaaa ctgtgactaa agtctatgaa 1020 actgattaca acagactgta agaatcaaag tcaactgaca tctatgctac atattattat 1080 atagtttgta ctgagctatt gaagtcccat taacttaaag tatatgtttt caaattgcca 1140 ttgctactat tgcttgtcgg tgttatttta ttttattgtt tttgactttg gaagagatga 1200 actgtgtatt taacttaagc tattgctctt aaaaccaggg agtcagaata tatttgtaag 1260 ttaaatcatt ggtgctaata ataaatgtgg attttgtatt aaaatatata gaagcaattt 1320 ctgtttacat gtccttgcta cttttaaaaa cttgcattta ttcctcagat tttaaaaata 1380 aataaataat tcatttaaga ttc 1403 <210> 45 <211> 1832 <212> DNA <213> Homo sapiens <400> 45 gctggctggc tccgcaggtc cgctgacgtc gccgcccaga tggcctccag gctgaccctg 60 ctgaccctcc tgctgctgct gctggctggg gatagagcct cctcaaatcc aaatgctacc 120 agctccagct cccaggatcc agagagtttg caagacagag gcgaagggaa ggtcgcaaca 180 acagttatct ccaagatgct attcgttgaa cccatcctgg aggtttccag cttgccgaca 240 accaactcaa caaccaattc agccaccaaa ataacagcta ataccactga tgaacccacc 300 acacaaccca ccacagagcc caccacccaa cccaccatcc aacccaccca accaactacc 360 cagctcccaa cagattctcc tacccagccc actactgggt ccttctgccc aggacctgtt 420 actctctgct ctgacttgga gagtcattca acagaggccg tgttggggga tgctttggta 480 gatttctccc tgaagctcta ccacgccttc tcagcaatga agaaggtgga gaccaacatg 540 gccttttccc cattcagcat cgccagcctc cttacccagg tcctgctcgg ggctggggag 600 aacaccaaaa caaacctgga gagcatcctc tcttacccca aggacttcac ctgtgtccac 660 caggccctga agggcttcac gaccaaaggt gtcacctcag tctctcagat cttccacagc 720 ccagacctgg ccataaggga cacctttgtg aatgcctctc ggaccctgta cagcagcagc 780 cccagagtcc taagcaacaa cagtgacgcc aacttggagc tcatcaacac ctgggtggcc 840 aagaacacca acaacaagat cagccggctg ctagacagtc tgccctccga tacccgcctt 900 gtcctcctca atgctatcta cctgagtgcc aagtggaaga caacatttga tcccaagaaa 960 accagaatgg aaccctttca cttcaaaaac tcagttataa aagtgcccat gatgaatagc 1020 aagaagtacc ctgtggccca tttcattgac caaactttga aagccaaggt ggggcagctg 1080 cagctctccc acaatctgag tttggtgatc ctggtacccc agaacctgaa acatcgtctt 1140 gaagacatgg aacaggctct cagcccttct gttttcaagg ccatcatgga gaaactggag 1200 atgtccaagt tccagcccac tctcctaaca ctaccccgca tcaaagtgac gaccagccag 1260 gatatgctct caatcatgga gaaattggaa ttcttcgatt tttcttatga ccttaacctg 1320 tgtgggctga cagaggaccc agatcttcag gtttctgcga tgcagcacca gacagtgctg 1380 gaactgacag agactggggt ggaggcggct gcagcctccg ccatctctgt ggcccgcacc 1440 ctgctggtct ttgaagtgca gcagcccttc ctcttcgtgc tctgggacca gcagcacaag 1500 ttccctgtct tcatggggcg agtatatgac cccagggcct gagacctgca ggatcaggtt 1560 agggcgagcg ctacctctcc agcctcagct ctcagttgca gccctgctgc tgcctgcctg 1620 gacttggccc ctgccacctc ctgcctcagg tgtccgctat ccaccaaaag ggctccctga 1680 gggtctgggc aagggacctg cttctattag cccttctcca tggccctgcc atgctctcca 1740 aaccactttt tgcagctttc tctagttcaa gttcaccaga ctctataaat aaaacctgac 1800 agaccatgac tttcaaaaaa aaaaaaaaaa aa 1832 <210> 46 <211> 5503 <212> DNA <213> Homo sapiens <400> 46 tttgaataca ccaattgctg tggggcggct cgaggaagag aagacaccag tgcctcagaa 60 actgctcggt cagacggtga tagcgagcca cgcattcaca gggccactgc tgctcacaga 120 agcagtgagg atgatgccag gatgatgtct gcctcgcgcc tggctgggac tctgatccca 180 gccatggcct tcctctcctg cgtgagacca gaaagctggg agccctgcgt ggaggtggtt 240 cctaatatta cttatcaatg catggagctg aatttctaca aaatccccga caacctcccc 300 ttctcaacca agaacctgga cctgagcttt aatcccctga ggcatttagg cagctatagc 360 ttcttcagtt tcccagaact gcaggtgctg gatttatcca ggtgtgaaat ccagacaatt 420 gaagatgggg catatcagag cctaagccac ctctctacct taatattgac aggaaacccc 480 atccagagtt tagccctggg agccttttct ggactatcaa gtttacagaa gctggtggct 540 gtggagacaa atctagcatc tctagagaac ttccccattg gacatctcaa aactttgaaa 600 gaacttaatg tggctcacaa tcttatccaa tctttcaaat tacctgagta tttttctaat 660 ctgaccaatc tagagcactt ggacctttcc agcaacaaga ttcaaagtat ttattgcaca 720 gacttgcggg ttctacatca aatgccccta ctcaatctct ctttagacct gtccctgaac 780 cctatgaact ttatccaacc aggtgcattt aaagaaatta ggcttcataa gctgacttta 840 agaaataatt ttgatagttt aaatgtaatg aaaacttgta ttcaaggtct ggctggttta 900 gaagtccatc gtttggttct gggagaattt agaaatgaag gaaacttgga aaagtttgac 960 aaatctgctc tagagggcct gtgcaatttg accattgaag aattccgatt agcatactta 1020 gactactacc tcgatgatat tattgactta tttaattgtt tgacaaatgt ttcttcattt 1080 tccctggtga gtgtgactat tgaaagggta aaagactttt cttataattt cggatggcaa 1140 catttagaat tagttaactg taaatttgga cagtttccca cattgaaact caaatctctc 1200 aaaaggctta ctttcacttc caacaaaggt gggaatgctt tttcagaagt tgatctacca 1260 agccttgagt ttctagatct cagtagaaat ggcttgagtt tcaaaggttg ctgttctcaa 1320 agtgattttg ggacaaccag cctaaagtat ttagatctga gcttcaatgg tgttattacc 1380 atgagttcaa acttcttggg cttagaacaa ctagaacatc tggatttcca gcattccaat 1440 ttgaaacaaa tgagtgagtt ttcagtattc ctatcactca gaaacctcat ttaccttgac 1500 atttctcata ctcacaccag agttgctttc aatggcatct tcaatggctt gtccagtctc 1560 gaagtcttga aaatggctgg caattctttc caggaaaact tccttccaga tatcttcaca 1620 gagctgagaa acttgacctt cctggacctc tctcagtgtc aactggagca gttgtctcca 1680 acagcattta actcactctc cagtcttcag gtactaaata tgagccacaa caacttcttt 1740 tcattggata cgtttcctta taagtgtctg aactccctcc aggttcttga ttacagtctc 1800 aatacacataa tgacttccaa aaaacaggaa ctacagcatt ttccaagtag tctagctttc 1860 ttaaatctta ctcagaatga ctttgcttgt acttgtgaac accagagttt cctgcaatgg 1920 atcaaggacc agaggcagct cttggtggaa gttgaacgaa tggaatgtgc aacaccttca 1980 gataagcagg gcatgcctgt gctgagtttg aatatcacct gtcagatgaa taagaccatc 2040 attggtgtgt cggtcctcag tgtgcttgta gtatctgttg tagcagttct ggtctataag 2100 ttctattttc acctgatgct tcttgctggc tgcataaagt atggtagagg tgaaaacatc 2160 tatgatgcct ttgttatcta ctcaagccag gatgaggact gggtaaggaa tgagctagta 2220 aagaatttag aagaaggggt gcctccattt cagctctgcc ttcactacag agactttatt 2280 cccggtgtgg ccattgctgc caacatcatc catgaaggtt tccataaaag ccgaaaggtg 2340 attgttgtgg tgtcccagca cttcatccag agccgctggt gtatctttga atatgagatt 2400 gctcagacct ggcagtttct gagcagtcgt gctggtatca tcttcattgt cctgcagaag 2460 gtggagaaga ccctgctcag gcagcaggtg gagctgtacc gccttctcag caggaacact 2520 tacctggagt gggaggacag tgtcctgggg cggcacatct tctggagacg actcagaaaa 2580 gccctgctgg atggtaaatc atggaatcca gaaggaacag tgggtacagg atgcaattgg 2640 caggaagcaa catctatctg aagaggaaaa ataaaaacct cctgaggcat ttcttgccca 2700 gctgggtcca acacttgttc agttaataag tattaaatgc tgccacatgt caggccttat 2760 gctaagggtg agtaattcca tggtgcacta gatatgcagg gctgctaatc tcaaggagct 2820 tccagtgcag agggaataaa tgctagacta aaatacagag tcttccaggt gggcatttca 2880 accaactcag tcaaggaacc catgacaaag aaagtcattt caactcttac ctcatcaagt 2940 tgaataaaga cagagaaaac agaaagagac attgttcttt tcctgagtct tttgaatgga 3000 aattgtatta tgttatagcc atcataaaac cattttggta gttttgactg aactgggtgt 3060 tcactttttc ctttttgatt gaatacaatt taaattctac ttgatgactg cagtcgtcaa 3120 ggggctcctg atgcaagatg ccccttccat tttaagtctg tctccttaca gaggttaaag 3180 tctagtggct aattcctaag gaaacctgat taacacatgc tcacaaccat cctggtcatt 3240 ctcgagcatg ttctattttt taactaatca cccctgatat atttttattt ttatatatcc 3300 agttttcatt tttttacgtc ttgcctataa gctaatatca taaataaggt tgtttaagac 3360 gtgcttcaaa tatccatatt aaccactatt tttcaaggaa gtatggaaaa gtacactctg 3420 tcactttgtc actcgatgtc attccaaagt tattgcctac taagtaatga ctgtcatgaa 3480 agcagcattg aaataatttg tttaaagggg gcactctttt aaacgggaag aaaatttccg 3540 cttcctggtc ttatcatgga caatttgggc tagaggcagg aaggaagtgg gatgacctca 3600 ggaggtcacc ttttcttgat tccagaaaca tatgggctga taaacccggg gtgacctcat 3660 gaaatgagtt gcagcagaag tttatttttt tcagaacaag tgatgtttga tggacctctg 3720 aatctcttta gggagacaca gatggctggg atccctcccc tgtacccttc tcactgccag 3780 gagaactacg tgtgaaggta ttcaaggcag ggagtataca ttgctgtttc ctgttgggca 3840 atgctccttg accacatttt gggaagagtg gatgttatca ttgagaaaac aatgtgtctg 3900 gaattaatgg ggttcttata aagaaggttc ccagaaaaga atgttcatcc agcctcctca 3960 gaaacagaac attcaagaaa aggacaatca ggatgtcatc agggaaatga aaataaaaac 4020 cacaatgaga tatcacctta taccaggtag aatggctact ataaaaaaat gaagtgtcat 4080 caaggatata gagaaattgg aacccttctt cactgctgga gggaatggaa aatggtgtag 4140 ccgttatgaa aaacagtacg gaggtttctc aaaaattaaa aatagaactg ctatatgatc 4200 cagcaatctc acttctgtat atatacccaa aataattgaa atcagaattt caagaaaata 4260 tttacactcc catgttcatt gtggcactct tcacaatcac tgtttccaaa gttatgaaa 4320 caacccaaat ttccattgaa aaataaatgg acaaagaaaa tgtgcatata cgtacaatgg 4380 gatattattc agcctaaaaa aagggggaat cctgttattt atgacaacat gaataaaccc 4440 ggaggccatt atgctatgta aaatgagcaa gtaacagaaa gacaaatact gcctgatttc 4500 atttatatga ggttctaaaa tagtcaaact catagaagca gagaatagaa cagtggttcc 4560 tagggaaaag gaggaaggga gaaatgagga aatagggagt tgtctaattg gtataaaatt 4620 atagtatgca agatgaatta gctctaaaga tcagctgtat agcagagttc gtataatgaa 4680 caatactgta ttatgcactt aacattttgt taagagggta cctctcatgt taagtgttct 4740 taccatatac atatacacaa ggaagctttt ggaggtgatg gatatattta ttaccttgat 4800 tgtggtgatg gtttgacagg tatgtgacta tgtctaaact catcaaattg tatacattaa 4860 atatatgcag ttttataata tcaattatgt ctgaatgaag ctataaaaaa gaaaagacaa 4920 caaaattcag ttgtcaaaac tggaaatatg accacagtca gaagtgtttg ttactgagtg 4980 tttcagagtg tgtttggttt gagcaggtct agggtgattg aacatccctg ggtgtgtttc 5040 catgtctcat gtactagtga aagtagatgt gtgcatttgt gcacatatcc ctatgtatcc 5100 ctatcagggc tgtgtgtatt tgaaagtgtg tgtgtccgca tgatcatatc tgtatagaag 5160 agagtgtgat tatatttctt gaagaataca tccatttgaa atggatgtct atggctgttt 5220 gagatgagtt ctctactctt gtgcttgtac agtagtctcc ccttatccct tatgcttggt 5280 ggatacgttc ttagacccca agtggatctc tgagaccgca gatggtacca aacctcatat 5340 atgcaatatt ttttcctata cataaatacc taagataaag ttcatcttct gaattaggca 5400 cagtaagaga ttaacaataa ctaacaataa aattgaatag ttataataat atattgtaat 5460 aaaagttatg tgaatgtgat ctctttcttt ctctctctca aaa 5503 <210> 47 <211> 1377 <212> DNA <213> Homo sapiens <400> 47 agcatcctga gtaatgagtg gcctgggccg gagcaggcga ggtggccgga gccgtgtgga 60 ccaggaggag cgctttccac agggcctgtg gacgggggtg gctatgagat cctgccccga 120 agagcagtac tgggatcctc tgctgggtac ctgcatgtcc tgcaaaacca tttgcaacca 180 tcagagccag cgcacctgtg cagccttctg caggtcactc agctgccgca aggagcaagg 240 caagttctat gaccatctcc tgagggactg catcagctgt gcctccatct gtggacagca 300 ccctaagcaa tgtgcatact tctgtgagaa caagctcagg agcccagtga accttccacc 360 agagctcagg agacagcgga gtggagaagt tgaaaacaat tcagacaact cgggaaggta 420 ccaaggattg gagcacagag gctcagaagc aagtccagct ctcccggggc tgaagctgag 480 tgcagatcag gtggccctgg tctacagcac gctggggctc tgcctgtgtg ccgtcctctg 540 ctgcttcctg gtggcggtgg cctgcttcct caagaagagg ggggatccct gctcctgcca 600 gccccgctca aggccccgtc aaagtccggc caagtcttcc caggatcacg cgatggaagc 660 cggcagccct gtgagcacat cccccgagcc agtggagacc tgcagcttct gcttccctga 720 gtgcagggcg cccacgcagg agagcgcagt cacgcctggg acccccgacc ccacttgtgc 780 tggaaggtgg gggtgccaca ccaggaccac agtcctgcag ccttgcccac acatcccaga 840 cagtggcctt ggcattgtgt gtgtgcctgc ccaggagggg ggcccaggtg cataaatggg 900 ggtcagggag ggaaaggagg agggagagag atggagagga ggggagagag aaagagaggt 960 ggggagaggg gagagagata tgaggagaga gagacagagg aggcagagag ggagagaaac 1020 agaggagaca gagagggaga gagagacaga gggagagaga gacagagggg aagagaggca 1080 gagagggaaa gaggcagaga aggaaagaga caggcagaga aggagagagg cagagaggga 1140 gagaggcaga gagggagaga ggcagagaga cagagaggga gagagggaca gagagagata 1200 gagcaggagg tcggggcact ctgagtccca gttcccagtg cagctgtagg tcgtcatcac 1260 ctaaccacac gtgcaataaa gtcctcgtgc ctgctgctca cagcccccga gagcccctcc 1320 tcctggagaa taaaaccttt ggcagctgcc cttcctcaaa aaaaaaaaaaaaaaaaa 1377 <210> 48 <211> 994 <212> DNA <213> Homo sapiens <400> 48 aagactcaaa cttagaaact tgaattagat gtggtattca aatccttagc tgccgcgaag 60 cccccgtaag aacccacgaa gcaggcgaag ttcattgttc tcaacattct 120 agctgctctt gctgcatttg ctctggaatt cttgtagaga tattacttgt ccttccaggc 180 tgttctttct gtagctccct tgttttcttt ttgtgatcat gttgcagatg gctgggcagt 240 gctcccaaaa tgaatatttt gacagtttgt tgcatgcttg cataccttgt caacttcgat 300 gttcttctaa tactcctcct ctaacatgtc agcgttattg taatgcaagt gtgaccaatt 360 cagtgaaagg aacgaatgcg attctctgga cctgtttggg actgagctta ataatttctt 420 tggcagtttt cgtgctaatg tttttgctaa ggaagataaa ctctgaacca ttaaaggacg 480 agtttaaaaa cacaggatca ggtctcctgg gcatggctaa cattgacctg gaaaagagca 540 ggactggtga tgaaattatt cttccgagag gcctcgagta cacggtggaa gaatgcacct 600 gtgaagactg catcaagagc aaaccgaagg tcgactctga ccattgcttt ccactcccag 660 ctatggagga aggcgcaacc attcttgtca ccacgaaaac gaatgactat tgcaagagcc 720 tgccagctgc tttgagtgct acggagatag agaaatcaat ttctgctagg taattaacca 780 tttcgactcg agcagtgcca ctttaaaaat cttttgtcag aatagatgat gtgtcagatc 840 tctttaggat gactgtattt ttcagttgcc gatacagctt tttgtcctct aactgtggaa 900 actctttatg ttagatatat ttctctaggt tactgttggg agcttaatgg tagaaacttc 960 cttggtttca tgattaaact cttttttttc ctga 994 <210> 49 <211> 1776 <212> DNA <213> Homo sapiens <400> 49 tttcatttcc tcactgacta taaaagaata gagaaggaag ggcttcagtg accggctgcc 60 tggctgactt acagcagtca gactctgaca ggatcatggc tatgatggag gtccaggggg 120 gacccagcct gggacagacc tgcgtgctga tcgtgatctt cacagtgctc ctgcagtctc 180 tctgtgtggc tgtaacttac gtgtacttta ccaacgagct gaagcagatg caggacaagt 240 actccaaaag tggcattgct tgtttcttaa aagaagatga cagttattgg gaccccaatg 300 acgaagagag tatgaacagc ccctgctggc aagtcaagtg gcaactccgt cagctcgtta 360 gaaagatgat tttgagaacc tctgaggaaa ccatttctac agttcaagaa aagcaacaaa 420 atatttctcc cctagtgaga gaaagaggtc ctcagagagt agcagctcac ataactggga 480 ccagaggaag aagcaacaca ttgtcttctc caaactccaa gaatgaaaag gctctgggcc 540 gcaaaataaa ctcctgggaa tcatcaagga gtgggcattc attcctgagc aacttgcact 600 tgaggaatgg tgaactggtc atccatgaaa aagggtttta ctacatctat tcccaaacat 660 actttcgatt tcaggaggaa ataaaagaaa acacaaagaa cgacaaacaa atggtccaat 720 atatttacaa atacacaagt tatcctgacc ctatattgtt gatgaaaagt gctagaaata 780 gttgttggtc taaagatgca gaatatggac tctattccat ctatcaaggg ggaatatttg 840 agcttaagga aaatgacaga atttttgttt ctgtaacaaa tgagcacttg atagacatgg 900 accatgaagc cagttttttc ggggcctttt tagttggcta actgacctgg aaagaaaaag 960 caataacctc aaagtgacta ttcagttttc aggatgatac actatgaaga tgtttcaaaa 1020 aatctgacca aaacaaacaa acagaaaaca gaaaacaaaa aaacctctat gcaatctgag 1080 tagagcagcc acaaccaaaa aattctacaa cacacactgt tctgaaagtg actcacttat 1140 cccaagagaa tgaaattgct gaaagatctt tcaggactct acctcatatc agtttgctag 1200 cagaaatcta gaagactgtc agcttccaaa cattaatgca atggttaaca tcttctgtct 1260 ttataatcta ctccttgtaa agactgtaga agaaagagca acaatccatc tctcaagtag 1320 tgtatcacag tagtagcctc caggtttcct taagggacaa catccttaag tcaaaagaga 1380 gaagaggcac cactaaaaga tcgcagtttg cctggtgcag tggctcacac ctgtaatccc 1440 aacattttgg gaacccaagg tgggtagatc acgagatcaa gagatcaaga ccatagtgac 1500 caacatagtg aaaccccatc tctactgaaa gtacaaaaat tagctgggtg tgttggcaca 1560 tgcctgtagt cccagctact tgagaggctg aggcaagaga attgtttgaa cccgggaggc 1620 agaggttgca gtgtggtgag atcatgccac tacactccag cctggcgaca gagcgagact 1680 tggtttcaaa aaaaaaaaaa aaaaaaactt cagtaagtac gtgttatttt tttcaataaa 1740 attctattac agtatgtcaa aaaaaaaaaa aaaaaa 1776 <210> 50 <211> 3015 <212> DNA <213> Homo sapiens <400> 50 cagggtttat tgttatgtaa gttcttgttc agcttccttt gttttctttc acttctgaga 60 atttaacttt cgtttctcac tcagctcctg tggggaaact catttgtgga gaccagccct 120 ctggcttggt gagtgaatct ggtttacacc ggctcctgcc ctgccttcac tcttctcccc 180 tgattcaaga ctcctctgct ttggactgaa gcactgcagg agtttgtgac caagaacttc 240 aagagtcaag acagaaggaa gccaagggag cagtgcaatg gatttctcag taaaggtaga 300 catagagaag gaggtgacct gccccatctg cctggagctc ctgacagaac ctctgagcct 360 agattgtggc cacagcttct gccaagcctg catcactgca aagatcaagg agtcagtgat 420 catctcaaga ggggaaagca gctgtcctgt gtgtcagacc agattccagc ctgggaacct 480 ccgacctaat cggcatctgg ccaacatagt tgagagagtc aaagaggtca agatgagccc 540 acaggagggg cagaagagag atgtctgtga gcaccatgga aaaaaactcc agatcttctg 600 taaggaggat ggaaaagtca tttgctgggt ttgtgaactg tctcaggaac accaaggtca 660 ccaaacattc cgcataaacg aggtggtcaa ggaatgtcag gaaaagctgc aggtagccct 720 gcagaggctg ataaaggagg atcaagaggc tgagaagctg gaagatgaca tcagacaaga 780 gagaaccgcc tggaagaatt atatccagat cgagagacag aagattctga aagggttcaa 840 ggagagagag tgaggtgaat gtgctggata acctggcagc agctacagac cagctggtcc agcagaggca 960 ggatgccagc acgctcatct cagatctcca gcggaggttg aggggatcgt cagtagagat 1020 gctgcaggat gtgattgacg tcatgaaaag gagtgaaagc tggacattga agaagccaaa 1080 atctgtttcc aagaaactaa agagtgtatt ccgagtacca gatctgagtg ggatgctgca 1140 agttcttaaa gagctgacag atgtccagta ctactgggtg gacgtgatgc tgaatccagg 1200 cagtgccact tcgaatgttg ctatttctgt ggatcagaga caagtgaaaa ctgtacgcac 1260 ctgcacattt aagaattcaa atccatgtga tttttctgct tttggtgtct tcggctgcca 1320 atatttctct tcggggaaat attactggga agtagatgtg tctggaaaga ttgcctggat 1380 cctgggcgta cacagtaaaa taagtagtct gaataaaagg aagagctctg ggtttgcttt 1440 tgatccaagt gtaaattatt caaaagttta ctccagatat agacctcaat atggctactg 1500 ggttatagga ttacagaata catgtgaata taatgctttt gaggactcct cctcttctga 1560 tcccaaggtt ttgactctct ttatggctgt gcctccctgt cgtattgggg ttttcctaga 1620 ctatgaggca ggcattgtct catttttcaa tgtcacaaac cacggagcac tcatctacaa 1680 gttctctgg tgtcgctttt ctcgacctgc ttatccgtat ttcaatcctt ggaactgcct 1740 agtccccatg actgtgtgcc caccgagctc ctgagtgttc tcattccttt acccacttct 1800 gcatagtagc ccttgtgctg agactcagat tctgcacctg agttcatctc tactgagacc 1860 atctcttcct ttctttcccc ttcttttact tagaatgtct ttgtattcat ttgctagggc 1920 ttccatagca aagcatcata gattgctgat ttaaactgta attgtattgc cgtactgtgg 1980 gctggaaatc ccaaatctag attccagcag agttggttct ttctgaggtc tgcaaggaag 2040 ggctctgttc catgcctctc tccttggctt gtagaaggca tcttgtccct atgactcttc 2100 acattgtctt tatgtacatc tctgtgccca agttttccct ttttattaag acaccagtca 2160 tactggctc gggcccaccg ctaatgcctt aatgaaatca ttttaacatt atattctcta 2220 caaagacctt atttccaaat aagataatat ttggaggtat tgggaataaa aactccaaca 2280 tataaatttg aggaaggcac gatttcactc ataacaatct taccctttct tgcaagagat 2340 gcttgtacat tattttccta ataccttggt ttcactagta gtaaacatta ttattttttt 2400 tatatttgca aaggaaacat atctaatcct tcctatagaa agaacagtat tgctgtaatt 2460 ccttttcttt tcttcctcat ttcctctgcc ccttaaaaga ttgaagaaag agaaacttgt 2520 caactcatat ccacgttatc tagcaaagta cataagaatc tatcactaag taatgtatcc 2580 ttcagaatgt gttggtttac cagtgacacc ccatattcat cacaaaatta aagcaagaag 2640 tccatagtaa tttatttgct aatagtggat ttttaatgct cagagtttct gaggtcaaat 2700 tttatctttt cacttacaag ctctatgatc ttaaataatt tacttaatgt attttggtgt 2760 attttcctca aattaatatt ggtgttcaag actatatcta attcctctga tcactttgag 2820 aaacaaactt ttattaaatg taaggcactt ttctatgaat tttaaatata aaaataaata 2880 ttgttctgat tattactgaa aagatgtcag ccatttcaat gtcttgggaa acaatttttt 2940 gtttttgttc tgttttcttt ttgcttcaat aaaacaatag ctggctctaa aaaaaaaaaa 3000 aaaaaaaaaa aaaaa 3015 <210> 51 <211> 2948 <212> DNA <213> Homo sapiens <400> 51 aggtaatgat taatctgtca ggcacaaaag ggattgtttt ggggatttcg ggttctaagt 60 cgcagattca aacaaatagc agcgaacagg gaatgacagt tccaccagaa gacgattaag 120 ccacagcctc taattggaac ggcatttgta cagtcagaga ctcttaccag acatctccag 180 gaatctgtga gccattgtca aaacgtccat tttcatctgg ctgtgaaagt gaggaccaca 240 acaggtaggt attggtagaa acaggagtcc tcagagaagc cccaagatgc agcctgaggg 300 agcagaaaag ggaaaaagct tcaagcagag actggtcttg aagagcagct tagcgaaaga 360 aaccctctct gagttcttgg gcacgttcat cttgattgtc cttggatgtg gctgtgttgc 420 ccaagctatt ctcagtcgag gacgttttgg aggggtcatc actatcaatg ttggattttc 480 aatggcagtt gcaatggcca tttatgtggc tggcggtgtc tctggtggtc acatcaaccc 540 agctgtgtct ttagcaatgt gtctctttgg acggatgaaa tggttcaaat tgccatttta 600 tgtgggagcc cagttcttgg gagcctttgt gggggctgca accgtctttg gcatttacta 660 tgatggactt atgtcctttg ctggtggaaa actgctgatc gtgggagaaa atgcaacagc 720 acacattttt gcaacatacc cagctccgta tctatctctg gcgaacgcat ttgcagatca 780 agtggtggcc accatgatac tcctcataat cgtctttgcc atttttgact ccagaaactt 840 gggagccccc agaggcctag agcccattgc catcggcctc ctgattattg tcattgcttc 900 ctccctggga ctgaacagtg gctgtgccat gaacccagct cgagacctga gtcccagact 960 tttcactgcc ttggcaggct gggggtttga agtcttcaga gctggaaaca acttctggtg 1020 gattcctgta gtgggccctt tggttggtgc tgtcattgga ggcctcatct atgttcttgt 1080 cattgaaatc caccatccag agcctgactc agtctttaag gcagaacaat ctgaggacaa 1140 accagagaaa tatgaactca gtgtcatcat gtagtggcat gctcagctct ggatttgcag 1200 tcagtttggg attctcttca gaaagatggc atctaagtgt ctgtgttctt gtaagcctga 1260 ggtggaatcc acccagtttt gtctgctagc catatgggac atctaattgg aaaagcatct 1320 gcataaaagt ttggaaacaa tgaccacttc tctaccattg tcccccaccc caccccccag 1380 aataacgctg actgtcccct gaaacagcct tctctcctgc cctgtttatt tcatcctcga 1440 tgggaattct tgctaggtaa gcactaataa ctcggcatct tgacgatagt cccatttggg 1500 tggtttcagc tgcactatct gtatgaaatg gtgtcaccaa aacccttttc ttcagtatcg 1560 cctatgagt agtcaacata ttcatgaatt agggagctaa tgggttaagc ttccagttcc cgctatgcta 1680 ctggatttgt ataaatactg atattctcca aacctagtgg tgtagggagc aagagaatgc 1740 agctggaagg cacaagggga ggacattgtg gcattcagaa actgcaggag acaagatgaa 1800 tttgagaagc caaatggaat ttttaatgga aaccatttat cagattaatc tcttgctctc 1860 ctgcatttta gaggacacca attaatttcc tggtctttag tatataataa cctaaaatac 1920 cattgtaacc tcagtcatga aaaatacatc actctgtctt tttagctcaa atgattattc 1980 ctaattgccc acttgagaac agacatttga caagttatat caacgactgt gcttgtccat 2040 tattttacac atgccctaga agccaaaact gaaagccact ggatcctggt ctagctgaat 2100 cttcagagtg ggaggtctcc aaaaagatat taccttattg ggcttaacaa ttcacaaggc 2160 actttcacac ccattatcta atttaatcct cataatgact atgtgaggca aatgccacat 2220 tgcccatttt tcagataaag aaacaaaatc ttagggaaga taagttgagt tgtccaagag 2280 cacactgaaa gttgaatgtt atctaatgca ttcctctacc tttcagaaga tcagtagctg 2340 gctgagaatc tttgccaaat cttccttgct agccagaagt ggaattggca gcttctagaa 2400 tatgtacacc tctggacaaa atgttcctca atcttaagat acaaagaccc tcattgtctg 2460 ggtctattcc cacacttact gagtacagat gaaggaaagt ggtagcaatt taatcataac 2520 tttcatttgc tgaaaaacat tatgagaagg cctcccttcc taagccacct ctggtcttgc 2580 taagtcttga tcttgcttcc tgccagcacc aaacattaca ttcaggggat ttcctctggc 2640 tcagtctttt ccccttgaag ttctctaata gatgttactt ttgacaaaag atcgcctatg 2700 agttacaagc accaggggat gctctacatc aagggatgca ccttcagtca aactgtcaaa 2760 aagcccagaa ttcccaaagg cattaggttt cccaactgct ttgtgctgat atcagaacag 2820 cagaaattaa atgtgaaatg tttctgatga cttatgttct acaatctatg gacatacggg 2880 attttttttt cttgctttga agctacctgg atatttccta tttgaaataa aattgttcgg 2940 tcattgtt 2948 <210> 52 <211> 1497 <212> DNA <213> Homo sapiens <400> 52 aaagtgctgg gattacaggc atgagccgcc gcgccccgcc ccacgctcag tcttgaaatt 60 gtctggaacg ggaaacggca aacagcgaga tatccgagcg agagtcccgc cctgcatcag 120 tttgcggaac cgccttggta gaaggagaga aggggagtgg aggaagcacg ggactggagg 180 gccaaagtt ccccgatggc ggcccagggg tgcgcggcat cgcggctgct ccagctgctg 240 ctgcagcttc tgcttctact gttgctgctg gcggcgggcg gggcgcgcgc gcggtggcgc 300 ggggagggca ccagcgcaca cttgcgggac atcttcctgg gccgctgcgc cgagtaccgc 360 gcactgctga gtcccgagca gcggaacaag aactgcacag ccatctggga agcctttaaa 420 gtggcgctgg acaaggatcc ctgctccgtg ctgccctcag actatgacct ttttattaac 480 ttgtccaggc actctattcc cagagataag tccctgttct gggaaaatag ccacctcctt 540 gttaacagct ttgcagacaa cacccgtcgt tttatgcccc tgagcgatgt tctgtatggc 600 agggttgcag atttcttgag ctggtgtcga cagaaaaatg actctggact cgattaccaa 660 tcctgcccta catcagaaga ctgtgaaaat aatcctgtgg attccttttg gaaaagggca 720 tccatccagt attccaagga tagttctggg gtgatccacg tcatgctgaa tggttcagag 780 ccaacaggag cctatcccat caaaggtttt tttgcagatt atgaaattcc aaacctccag 840 aaggaaaaaa ttacacgaat cgagatctgg gttatgcatg aaattggggg acccaatgtg 900 gaatcctgcg gggaaggcag catgaaagtc ctggaaaaga ggctgaagga catggggttc 960 cagtacagct gtattaatga ttaccgacca gtgaagctct tacagtgcgt ggaccacagc 1020 acccatcctg actgtgcctt aaagtcggca gcagccgcta ctcaaagaaa agccccaagt 1080 ctttatacag aacaaagggc gggtcttatc attcccctct ttctggtgct ggcttccagg 1140 actcaactgt aactggaaac tgtgttgctc taaccctcct ccagccctgc agcctcccct 1200 tgcagtcatc attcgtgttc tgtgtatacc aaatgattct gttatctaaa gaagcttttt 1260 gctgggaaaa cgatgtcctg aaaatggtat ttcaatgagg catatgttca ggatttcaga 1320 aacaagaagt tagttctatt tagcaggtta aaaaatgctg cattagaatt aaagcaagtt 1380 attttcttat ttgtataatg acacaaagca ttgggagtca gactgcttgt atattatcaa 1440 acattttaag agaattctaa taaagctgta ttttacatca aaaaaaaaaaaaaaaaa 1497 <210> 53 <211> 2273 <212> DNA <213> Homo sapiens <400> 53 caggactgcc tgagacaagc cacaagctga acagagaaag tggattgaac aaggacgcat 60 ttccccagta catccacaac atgctgtcca catctcgttc tcggtttatc agaaatacca 120 acgagagcgg tgaagaagtc accacctttt ttgattatga ttacggtgct ccctgtcata 180 aatttgacgt gaagcaaatt ggggcccaac tcctgcctcc gctctactcg ctggtgttca 240 tctttggttt tgtgggcaac atgctggtcg tcctcatctt aataaactgc aaaaagctga 300 agtgcttgac tgacatttac ctgctcaacc tggccatctc tgatctgctt tttcttatta 360 ctctcccatt gtgggctcac tctgctgcaa atgagtgggt ctttgggaat gcaatgtgca 420 aattattcac agggctgtat cacatcggtt attttggcgg aatcttcttc atcatcctcc 480 tgacaatcga tagatacctg gctattgtcc atgctgtgtt tgctttaaaa gccaggacgg 540 tcacctttgg ggtggtgaca agtgtgatca cctggttggt ggctgtgttt gcttctgtcc 600 caggaatcat ctttactaaa tgccagaaag aagattctgt ttatgtctgt ggcccttatt 660 ttccacgagg atggaataat ttccacacaa taatgaggaa cattttgggg ctggtcctgc 720 cgctgctcat catggtcatc tgctactcgg gaatcctgaa aaccctgctt cggtgtcgaa 780 acgagaagaa gaggcatagg gcagtgagag tcatcttcac catcatgatt gtttactttc 840 tcttctggac tccctataac attgtcattc tcctgaacac cttccaggaa ttcttcggcc 900 tgagtaactg tgaaagcacc agtcaactgg accaagccac gcaggtgaca gagactcttg 960 ggatgactca ctgctgcatc aatcccatca tctatgcctt cgttggggag aagttcagaa 1020 gcctttttca catagctctt ggctgtagga ttgccccact ccaaaaacca gtgtgtggag 1080 gtccaggagt gagaccagga aagaatgtga aagtgactac acaaggactc ctcgatggtc 1140 gtggaaaagg aaagtcaatt ggcagagccc ctgaagccag tcttcaggac aaagaaggag 1200 cctagagaca gaaatgacag atctctgctt tggaaatcac acgtctggct tcacagatgt 1260 gtgattcaca gtgtgaatct tggtgtctac gttaccaggc aggaaggctg agaggagaga 1320 gactccagct gggttggaaa acagtatttt ccaaactacc ttccagttcc tcatttttga 1380 atacaggcat agagttcaga ctttttttaa atagtaaaaa taaaattaaa gctgaaaact 1440 gcaacttgta aatgtggtaa agagttagtt tgagttgcta tcatgtcaaa cgtgaaaatg 1500 ctgtattagt cacagagata attctagctt tgagcttaag aattttgagc aggtggtatg 1560 tttgggagac tgctgagtca acccaatagt tgttgattgg caggagttgg aagtgtgtga 1620 tctgtgggca cattagccta tgtgcatgca gcatctaagt aatgatgtcg tttgaatcac 1680 agtatacgct ccatcgctgt catctcagct ggatctccat tctctcaggc ttgctgccaa 1740 aagccttttg tgttttgttt tgtatcatta tgaagtcatg cgtttaatca cattcgagtg 1800 tttcagtgct tcgcagatgt ccttgatgct catattgttc cctaatttgc cagtgggaac 1860 tcctaaatca aattggcttc taatcaaagc ttttaaaccc tattggtaaa gaatggaagg 1920 tggagaagct ccctgaagta agcaaagact ttcctcttag tcgagccaag ttaagaatgt 1980 tcttatgttg cccagtgtgt ttctgatctg atgcaagcaa gaaacactgg gcttctagaa 2040 ccaggcaact tgggaactag actcccaagc tggactatgg ctctactttc aggccacatg 2100 gctaaagaag gtttcagaaa gaagtgggga cagagcagaa ctttcacctt catatatttg 2160 tatgatccta atgaatgcat aaaatgttaa gttgatggtg atgaaatgta aatactgttt 2220 ttaacaacta tgatttggaa aataaatcaa tgctataact atgttgataa aag 2273 <210> 54 <211> 1320 <212> DNA <213> Homo sapiens <400> 54 cggaagggga agggggtgga ggttgctgct atgagagaga aaaaaaaaac agccacaata 60 gagattctgc cttcaaaggt tggcttgcca cctgaagcag ccactgccca gggggtgcaa 120 agaagagaca gcagcgccca gcttggaggt gctaactcca gaggccagca tcagcaactg 180 ggcacagaaa ggagccgcct gggcagggac catggcacgg ccacatccct ggtggctgtg 240 cgttctgggg accctggtgg ggctctcagc tactccagcc cccaagagct gcccagagag 300 gcactactgg gctcagggaa agctgtgctg ccagatgtgt gagccaggaa cattcctcgt 360 gaaggactgt gaccagcata gaaaggctgc tcagtgtgat ccttgcatac cgggggtctc 420 cttctctcct gaccaccaca cccggcccca ctgtgagagc tgtcggcact gtaactctgg 480 tcttctcgtt cgcaactgca ccatcactgc caatgctgag tgtgcctgtc gcaatggctg 540 gcagtgcagg gacaaggagt gcaccgagtg tgatcctctt ccaaaccctt cgctgaccgc 600 tcggtcgtct caggccctga gcccacaccc tcagcccacc cacttacctt atgtcagtga 660 gatgctggag gccaggacag ctgggcacat gcagactctg gctgacttca ggcagctgcc 720 tgcccggact ctctctaccc actggccacc ccaaagatcc ctgtgcagct ccgattttat 780 tcgcatcctt gtgatcttct ctggaatgtt ccttgttttc accctggccg gggccctgtt 840 cctccatcaa cgaaggaaat atagatcaaa caaaggagaa agtcctgtgg agcctgcaga 900 gccttgtcgt tacagctgcc ccagggagga ggagggcagc accatcccca tccaggagga 960 ttaccgaaaa ccggagcctg cctgctcccc ctgagccagc acctgcggga gctgcactac 1020 agccctggcc tccaccccca ccccgccgac catccaaggg agagtgagac ctggcagcca 1080 caactgcagt cccatcctct tgtcagggcc ctttcctgtg tacacgtgac agagtgcctt 1140 ttcgagactg gcagggacga ggacaaatat ggatgaggtg gagagtggga agcaggagcc 1200 cagccagctg cgcctgcgct gcaggagggc gggggctctg gttgtaaaac acacttcctg 1260 ctgcgaaaga cccacatgct acaagacggg caaaataaag tgacagatga ccaccctgca 1320                                                                         1320 <210> 55 <211> 1303 <212> DNA <213> Homo sapiens <400> 55 ctgcagccgg tgcagttaca cgttttcctc caaggagcct cggacgttgt cacgggtttg 60 gggtcgggga cagagcggtg accatggcca ggctggcgtt gtctcctgtg cccagccact 120 ggatggtggc gttgctgctg ctgctctcag cagctgagcc agtaccagca gccagatcgg 180 aggaccggta ccggaatccc aaaggtagtg cttgttcgcg gatctggcag agcccacgtt 240 tcatagccag gaaacggggc ttcacggtga aaatgcactg ctacatgaac agcgcctccg 300 gcaatgtgag ctggctctgg aagcaggaga tggacgagaa tccccagcag ctgaagctgg 360 aaaagggccg catggaagag tcccagaacg aatctctcgc caccctcacc atccaaggca 420 tccggtttga ggacaatggc atctacttct gtcagcagaa gtgcaacaac acctcggagg 480 tctaccaggg ctgcggcaca gagctgcgag tcatgggatt cagcaccttg gcacagctga 540 agcagaggaa cacgctgaag gatggtatca tcatgatcca gacgctgctg atcatcctct 600 tcatcatcgt gcctatcttc ctgctgctgg acaaggatga cagcaaggct ggcatggagg 660 aagatcacac ctacgagggc ctggacattg accagacagc cacctatgag gacatagtga 720 cgctgcggac aggggaagtg aagtggtctg taggtgagca cccaggccag gagtgagagc 780 caggtcgccc catgacctgg gtgcaggctc cctggcctca gtgactgctt cggagctgcc 840 tggctcatgg cccaacccct ttcctggacc ccccagctgg cctctgaagc tggcccacca 900 gagctgccat ttgtctccag cccctggtcc ccagctcttg ccaaagggcc tggagtagaa 960 ggacacaagg gcagcaactt ggagggagtt ctctggggat ggacgggacc cagccttctg 1020 ggggtgctat gaggtgatcc gtccccacac atgggatggg ggaggcagag actggtccag 1080 agcccgcaaa tggactcgga gccgagggcc tcccagcaga gcttgggaag ggccatggac 1140 ccaactgggc cccagaagag ccacaggaac atcattcctc tcccgcaacc actcccaccc 1200 cagggaggcc ctggcctcca gtgccttccc ccgtggaata aacggtgtgt cctgagaaac 1260 cacaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1303 <210> 56 <211> 655 <212> DNA <213> Homo sapiens <400> 56 atgcgcgcaa gagagcggga agccgagctg ggcgagaagt aggggagggc ggtgctccgc 60 cgcggtggcg gttgctatcg cttcgcagaa cctactcagg cagccagctg agaagagttg 120 agggaaagtg ctgctgctgg gtctgcagac gcgatggata acgtgcagcc gaaaataaaa 180 catcgcccct tctgcttcag tgtgaaaggc cacgtgaaga tgctgcggct ggcactaact 240 gtgacatcta tgaccttttt tatcatcgca caagcccctg aaccatatat tgttatcact 300 ggatttgaag tcaccgttat cttatttttc atacttttat atgtactcag acttgatcga 360 ttaatgaagt ggttattttg gcctttgctt gatattatca actcactggt aacaacagta 420 ttcatgctca tcgtatctgt gttggcactg ataccagaaa ccacaacatt gacagttggt 480 ggagggttat tttaactcag tataggagct agaggaagag atttccgaag tctgcacccc 540 gcgcagagca ctactgtaac ttccaaggga gcgctgggag cagcgggatc gggttttccg 600 gcacccgggc ctgggtggca gggaagaatg tgccgggatc cgcctcaggg atctt 655 <210> 57 <211> 4100 <212> DNA <213> Homo sapiens <400> 57 gtacctcatg tgacaagttc caatttcttt tcaagtcaat tgaactgaaa tctccttgtt 60 gctttgaaat cttagaagag agcccactaa ttcaaggact cttactgtgg gagcaactgc 120 tggttctatc acaatgaaac ggctggtttg tgtgctcttg gtgtgctcct ctgcagtggc 180 acagttgcat aaagatccta ccctggatca ccactggcat ctctggaaga aaacctatgg 240 caaacaatac aaggaaaaga atgaagaagc agtacgacgt ctcatctggg aaaagaatct 300 aaagtttgtg atgcttcaca acctggagca ttcaatggga atgcactcat acgatctggg 360 catgaaccac ctgggagaca tgaccagtga agaagtgatg tctttgatga gttccctgag 420 agttcccagc cagtggcaga gaaatatcac atataagtca aaccctaatc ggatattgcc 480 tgattctgtg gactggagag agaaagggtg tgttactgaa gtgaaatatc aaggttcttg 540 tggtgcttgc tgggctttca gtgctgtggg ggccctggaa gcacagctga agctgaaaac 600 aggaaagctg gtgtctctca gtgcccagaa cctggtggat tgctcaactg aaaaatatgg 660 aaacaaaggc tgcaatggtg gcttcatgac aacggctttc cagtacatca ttgataacaa 720 gggcatcgac tcagacgctt cctatcccta caaagccatg gatcagaaat gtcaatatga 780 ctcaaaatat cgtgctgcca catgttcaaa gtacactgaa cttccttatg gcagagaaga 840 tgtcctgaaa gaagctgtgg ccaataaagg cccagtgtct gttggtgtag atgcgcgtca 900 tccttctttc ttcctctaca gaagtggtgt ctactatgaa ccatcctgta ctcagaatgt 960 gaatcatggt gtacttgtgg ttggctatgg tgatcttaat gggaaagaat actggcttgt 1020 gaaaaacagc tggggccaca actttggtga agaaggatat attcggatgg caagaaataa 1080 aggaaatcat tgtgggattg ctagctttcc ctcttaccca gaaatctaga ggatctctcc 1140 tttttataac aaatcaagaa atatgaagca ctttctctta acttaatttt tcctgctgta 1200 tccagaagaa ataattgtgt catgattaat gtgtatttac tgtactaatt agaaaatata 1260 gtttgaggcc gggcacggtg gctcacgcct gtaatcccag tacttgggag gccaaggcag 1320 gcatatcaac ttgaggccag gagttaaaga gcagcctggc taacatggtg aaaccccatc 1380 tctactaaaa atacaaaaaa ttagccgagc acggtggtgc atgcctgtaa tcccagctac 1440 ttgggaggct gaggcacgag attccttgaa cccaagaggt tgaggctatg ttgagctgag 1500 atcacaccac tgtactccag cctggatgac agagtggaga ctctgtttca aaaaaacaga 1560 aaagaaaata tagtttgatt cttcattttt ttaaatttgc aaatctcagg ataaagtttg 1620 ctaagtaaat tagtaatgta ctatagatat aactgtacaa aaattgttca acctaaaaca 1680 atctgtaatt gcttattgtt ttattgtata ctctttgtct ttttaagacc cctaatagcc 1740 ttttgtaact tgatggctta aaaatactta ataaatctgc catttcaaat ttctatcatt 1800 gccacatacc attcttattc ctaggcaact attaataatc tatcctgaga atattaattg 1860 tggtattctg gtgatggggt ttagcaactt tgatggaaga aaatattagg ctataaatgt 1920 cctaaggact cagattgtat ctttgtacag aagaggattc aaaacgccac gtgtagtggc 1980 tcatgcctgt aatcccaaca ctttgggagg ctgaagtagg aggatcgtct tgagcccagg 2040 agttcaagac cagcctggac aacatagtga gaccttgtct ccacaaaaat aaaaaagaaa 2100 ctatccagga gtggtggtgt gtgcctgtgg tccctgctat gcagatgtct aagacaggag 2160 gatcacaaga gcccaggagg ttgagaatgc agtgagcttg taattgcacc actgcactcc 2220 agcctgggtg acagagcaag accctgtctt aaaaaaagag gattcaacac atatttttat 2280 attatgttaa agtaaagaaa tgcataaaag acaagcactt tggaagaatt attttaatga 2340 tcaacaattt aatgtattag tccaaattat ttttacgtag tcatcaacaa tttgaccagg 2400 gcctttattt ggcaaataac tgagccaacc agaataaaat aaccaatact ccactgctca 2460 tatttttatc taattcagat ggatcttcct tacaactgct ctagattagt agatgcatct 2520 aagcaggcag caggaacttt aaatttttta agttcatgtc tatgacatga acaatgtgtg 2580 ggataatgtc attaatatat cctaaattaa cctaaacgta tttcactaac tctggctcct 2640 tctccataaa gcacatttta aggaacaaga attgctaaat ataaaaacat aaataatacc 2700 ataatacatg gctatcatca aaagtgtata gaatattata gtttaaaagt atttagttga 2760 ttacttttca gttttgtttt gttttttgag acggagtctc actctgttgc ccaggctgga 2820 gtgcagtggc accatctcag ttcactgcaa cttctgcctc ccgagttcaa gcgattctcc 2880 tgcctcagcc tcccgagtag ctggaattat aggcgtgcac caccacgccc agctaatttt 2940 tgtattttta gtaaagacag ggttttgcca cattagccag gctggtctca aactcctgac 3000 ctcaggtgat ccacccaccc cagcctccca aagtgctaag attacaggcg tgagccactg 3060 agcccagcct acttttcagt ttttaacata atttttgttt tatccacaac ttttcaagta 3120 ttgaaagtag aataaaaaca tgggttctta gtctttagct atctgttaaa gcctatgaat 3180 gccttcttaa aatcatgttt ttaaatgcat aaaatatata ggattacaaa ggaatctaat 3240 tatatcgaaa tacagttatt aaaatgttaa aagataagtt tgttatatat taatatgcat 3300 gcttctttat aaatgcatta aataagagtt aatagctatc ctaaatttga aatagtgata 3360 agcataatga aaatagatgc aaaaaactaa tgtgatatga aaatatctgg gtttttcttt 3420 tgatgatgaa gtattgctaa tattaccgtg gtttatgaac tatgttcaga attgaagaaa 3480 atcctaactt tcagttagag gttagtgacg gggttcagga caccctacac aaaatacagc 3540 actttgacat attgaatatt ttaagctgaa ggcatttgag gaaattgcag aagcaggaag 3600 gtgactctga ccttctgcct gctgttctcc ccagaagcag ccataaaacc tgggaaggat 3660 tttctgacct tcccctgaag tagatcataa gactgtcatg taagaggtgc tctcctggca 3720 cccagagaaa aggagcatcc ttacctccaa aagcacaggg acacaaagag gaatctaaac 3780 aaacaggcct ctcagtttcc cccagtttat tacatttagc ttgttcacac tttgccctat 3840 gacatttcta catcactggc tgctcttcat caaacctact ataaaaaaca ttcaagttca 3900 actgtttctt tgggccttta tttccttatg gagcccctcg tgtcgtgtaa aacttatatt 3960 gccgctttt aaacctagga tggatagaag gaaacatatg ttctccccta cattagtaaa aataaaaatg 4080 gaatttttta cccatacaaa 4100 <210> 58 <211> 1566 <212> DNA <213> Homo sapiens <400> 58 gagtcagccc ccgggggagg ccatgaacgc cacggggacc ccggtggccc ccgagtcctg 60 ccaacagctg gcggccggcg ggcacagccg gctcattgtt ctgcactaca accactcggg 120 ccggctggcc gggcgcgggg ggccggagga tggcggcctg ggggccctgc gggggctgtc 180 ggtggccgcc agctgcctgg tggtgctgga gaacttgctg gtgctggcgg ccatcaccag 240 ccacatgcgg tcgcgacgct gggtctacta ttgcctggtg aacatcacgc tgagtgacct 300 gctcacgggc gcggcctacc tggccaacgt gctgctgtcg ggggcccgca ccttccgtct 360 ggcgcccgcc cagtggttcc tacgggaggg cctgctcttc accgccctgg ccgcctccac 420 cttcagcctg ctcttcactg caggggagcg ctttgccacc atggtgcggc cggtggccga 480 gagcggggcc accaagacca gccgcgtcta cggcttcatc ggcctctgct ggctgctggc 540 cgcgctgctg gggatgctgc ctttgctggg ctggaactgc ctgtgcgcct ttgaccgctg 600 ctccagcctt ctgcccctct actccaagcg ctacatcctc ttctgcctgg tgatcttcgc 660 cggcgtcctg gccaccatca tgggcctcta tggggccatc ttccgcctgg tgcaggccag 720 cgggcagaag gccccacgcc cagcggcccg ccgcaaggcc cgccgcctgc tgaagacggt 780 gctgatgatc ctgctggcct tcctggtgtg ctggggccca ctcttcgggc tgctgctggc 840 cgacgtcttt ggctccaacc tctgggccca ggagtacctg cggggcatgg actggatcct 900 ggccctggcc gtcctcaact cggcggtcaa ccccatcatc tactccttcc gcagcaggga 960 ggtgtgcaga gccgtgctca gcttcctctg ctgcgggtgt ctccggctgg gcatgcgagg 1020 gcccggggac tgcctggccc gggccgtcga ggctcactcc ggagcttcca ccaccgacag 1080 ctctctgagg ccaagggaca gctttcgcgg ctcccgctcg ctcagctttc ggatgcggga 1140 gcccctgtcc agcatctcca gcgtgcggag catctgaagt tgcagtcttg cgtgtggatg 1200 gtgcagccac cgggtgcgtg ccaggcaggc cctcctgggg tacaggaagc tgtgtgcacg 1260 cagcctcgcc tgtatgggga gcagggaacg ggacaggccc ccatggtctt cccggtggcc 1320 tctcggggct tctgacgcca aatgggcttc ccatggtcac cctggacaag gaggtaacca 1380 ccccacctcc ccgtaggagc agagagcacc ctggtgtggg ggcgagtggt tccccacaac 1440 cccgcttctg tgtgattctg gggaagtccc ggcccctctc tgggcctcag tagggctccc 1500 aggctgcaag gggtggactg tgggatgcat gccctggcaa cattgaagtt cgatcatggt 1560 aaaaaa 1566 <210> 59 <211> 1636 <212> DNA <213> Homo sapiens <400> 59 tccacccaag agcaacctgg aactaagtta ttcggcaacg aactgttcca ctttgttgtg 60 aggcaataga tgtggaaatt ccctgacgag gggctctgtc ctcatacttc ctgcggagct 120 tattgtcgta agaatatctg tcatcctgct aatgtgcatt gaaaggagag caacggggct 180 gaggccgtgt cagcacgatg gaccccaaac agaccaccct cctgtgtctt gtgctctgtc 240 tgggccagag gattcaggca caggaagggg actttcccat gcctttcata tctgccaaat 300 cgagtcctgt gattcccttg gatggatctg tgaaaatcca gtgccaggcc attcgtgaag 360 cttacctgac ccagctgatg atcataaaaa actccacgta ccgagagata ggcagaagac 420 tgaagttttg gaatgagact gatcctgagt tcgtcattga ccacatggac gcaaacaagg 480 cagggcgcta tcagtgccaa tataggatag ggcactacag attccggtac agtgacaccc 540 tggagctggt agtgacaggc ttgtatggca aacccttcct ctctgcagat cggggtctgg 600 tgttgatgcc aggagagaat atttccctca cgtgcagctc agcacacatc ccatttgata 660 gattttcact ggccaaggag ggagaacttt ctctgccaca gcaccaaagt ggggaacacc 720 cggccaactt ctctttgggt cctgtggacc tcaatgtctc agggatctac aggtgctacg 780 gttggtacaa caggagcccc tacctgtggt ccttccccag taatgccttg gagcttgtgg 840 tcacaggtag gtaccgccca gtccagccct gtgtctgggt tggctgtcca gggccttgcc 900 accgggcagg aatatgaaga cgtgcactga gagtgaagtg aagagaggca aaggctctca 960 ctccaggaca gtggagagag aaaggcttcc ccaccacact ttccgctttc acttcctcgc 1020 tagagttctc cagacagggt tcattgaaaa cttagtctgt ggagaacaga agggctaact 1080 cagtttgttt cattttattt atttcatttt attttccggg atagagtctt gctctttcgc 1140 caaggctgga gtgcagtggc acgatctcga ctcactgcaa ccttcgcctc ccaggttcaa 1200 gcaattctcc tgcctcagcc tcctgagtag ctgggaccac acagacaggg tttcaccatg 1260 ttggccaggc tggtctcgaa ctcccgacct caggtgatcc acctgcctcg gcctcccaaa 1320 gtgctgggat tacaggcgtg agccaccgcg cctggccagg ctgcacacat tcttattagg 1380 attccacctt gttctggtgt tgtagagatg tgattaggta tttagtgaat tcaccaagtg 1440 aggagagaat gaaaagaaaa cacaacctgc ctggccgggc gtggtggcgt gagcctgtcg 1500 tcccagctac tcaggaggct gaggcaggag aatcacttga acccaggagg cagctgttgc 1560 agtgagccaa gatcacgcca ttgcactcca gcctgggtga cagaacgaga ctccacctca 1620 agaaaaaaaa aaaaaa 1636 <210> 60 <211> 2295 <212> DNA <213> Homo sapiens <400> 60 gaattccaac tatggagacc caaatgtctc agaatgtatg tcccagaaac ctgtggctgc 60 ttcaaccatt gacagttttg ctgctgctgg cttctgcaga cagtcaagct gcagctcccc 120 caaaggctgt gctgaaactt gagcccccgt ggatcaacgt gctccaggag gactctgtga 180 ctctgacgg ccagggggct cgcagccctg agagcgactc cattcagtgg ttccacaatg 240 ggaatctcat tcccacccac acgcagccca gctacaggtt caaggccaac aacaatgaca 300 gcggggagta cacgtgccag actggccaga ccagcctcag cgaccctgtg catctgactg 360 tgctttccga atggctggtg ctccagaccc ctcacctgga gttccaggag ggagaaacca 420 tcatgctgag gtgccacagc tggaaggaca agcctctggt caaggtcaca ttcttccaga 480 atggaaaatc ccagaaattc tcccgtttgg atcccacctt ctccatccca caagcaaacc 540 acagtcacag tggtgattac cactgcacag gaaacatagg ctacacgctg ttctcatcca 600 agcctgtgac catcactgtc caagtgccca gcatgggcag ctcttcacca atggggatca 660 ttgtggctgt ggtcattgcg actgctgtag cagccattgt tgctgctgta gtggccttga 720 tctactgcag gaaaaagcgg atttcagcca attccactga tcctgtgaag gctgcccaat 780 ttgagccacc tggacgtcaa atgattgcca tcagaaagag acaacttgaa gaaaccaaca 840 atgactatga aacagctgac ggcggctaca tgactctgaa ccccagggca cctactgacg 900 atgataaaaa catctacctg actcttcctc ccaacgacca tgtcaacagt aataactaaa 960 gagtaacgtt atgccatgtg gtcatactct cagcttgctg agtggatgac aaaaagaggg 1020 gaattgttaa aggaaaattt aaatggagac tggaaaaatc ctgagcaaac aaaaccacct 1080 ggcccttaga aatagcttta actttgctta aactacaaac acaagcaaaa cttcacgggg 1140 tcatactaca tacaagcata agcaaaactt aacttggatc atttctggta aatgcttatg 1200 ttagaaataa gacaacccca gccaatcaca agcagcctac taacatataa ttaggtgact 1260 agggactttc taagaagata cctaccccca aaaaacaatt atgtaattga aaaccaaccg 1320 attgccttta ttttgcttcc acattttccc aataaatact tgcctgtgac attttgccac 1380 tggaacacta aacttcatga attgcgcctc agatttttcc tttaacatct tttttttttt 1440 tgacagagtc tcaatctgtt acccaggctg gagtgcagtg gtgctatctt ggctcactgc 1500 aaacccgcct cccaggttta agcgattctc atgcctcagc ctcccagtag ctgggattag 1560 aggcatgtgc catcataccc agctaatttt tgtatttttt attttttttt tttagtagag 1620 acagggtttc gcaatgttgg ccaggccgat ctcgaacttc tggcctctag cgatctgccc 1680 gcctcggcct cccaaagtgc tgggatgacc agcatcagcc ccaatgtcca gcctctttaa 1740 catcttcttt cctatgccct ctctgtggat ccctactgct ggtttctgcc ttctccatgc 1800 tgagaacaaa atcacctatt cactgcttat gcagtcggaa gctccagaag aacaaagagc 1860 ccaattacca gaaccacatt aagtctccat tgttttgcct tgggatttga gaagagaatt 1920 agagaggtga ggatctggta tttcctggac taaattcccc ttggggaaga cgaagggatg 1980 ctgcagttcc aaaagagaag gactcttcca gagtcatcta cctgagtccc aaagctccct 2040 gtcctgaaag ccacagacaa tatggtccca aatgactgac tgcaccttct gtgcctcagc 2100 cgttcttgac atcaagaatc ttctgttcca catccacaca gccaatacaa ttagtcaaac 2160 cactgttatt aacagatgta gcaacatgaa agacgctatg ttacaggtta catgagagca 2220 atcatgtaag tctatatgac ttcagaaatg ttaaaataga ctaacctcta acaacaaatt 2280 aaaagtgcgg aattc 2295 <210> 61 <211> 2300 <212> DNA <213> Homo sapiens <400> 61 agatgctcag ccgcagacct ttgggagagt aaagggggca cacccaccca ccttgcctcc 60 aggctctttc cttcctattc ctgttctatg gtggggctcc attgcgagac ttcagattga 120 gaaatcagat gaagtttcaa gaaaaggaaa ctggcaggtg acagagatgg gtggagggac 180 tggggaaagg ctgtttactc cctcctgtct agtcggcttg gtccctttag ggctccggat 240 atctttggtg acttgtccac tccagtgtgg catcatgtgg cagctgctcc tcccaactgc 300 tctgctactt ctagtttcag ctggcatgcg gactgaagat ctcccaaagg ctgtggtgtt 360 cctggagcct caatggtaca gcgtgcttga gaaggacagt gtgactctga agtgccaggg 420 agcctactcc cctgaggaca attccacaca gtggtttcac aatgagaacc tcatctcaag 480 ccaggcctcg agctacttca ttgacgctgc cacagtcaac gacagtggag agtacaggtg 540 ccagacaaac ctctccaccc tcagtgaccc ggtgcagcta gaagtccata tcggctggct 600 gttgctccag gcccctcggt gggtgttcaa ggaggaagac cctattcacc tgaggtgtca 660 cagctggaag aacactgctc tgcataaggt cacatattta cagaatggca aagacaggaa 720 gtattttcat cataattctg acttccacat tccaaaagcc acactcaaag atagcggctc 780 ctacttctgc agggggcttg ttgggagtaa aaatgtgtct tcagagactg tgaacatcac 840 catcactcaa ggtttggcag tgtcaaccat ctcatcattc tctccacctg ggtaccaagt 900 ctctttctgc ttggtgatgg tactcctttt tgcagtggac acaggactat atttctctgt 960 gaagacaaac atttgaagct caacaagaga ctggaaggac cataaactta aatggagaaa 1020 ggaccctcaa gacaaatgac ccccatccca tgggagtaat aagagcagtg gcagcagcat 1080 ctctgaacat ttctctggat ttgcaacccc atcatcctca ggcctctcta caagcagcag 1140 gaaacataga actcagagcc agatccttta tccaactctc gatttttcct tggtctccag 1200 tggaagggaa aagcccatga tcttcaagca gggaagcccc agtgagtagc tgcattccta 1260 gaaattgaag tttcagagct acacaaacac tttttctgtc ccaaccattc cctcacagca 1320 aagcaacaat acaggctagg gatggtaatc ctttaaacat acaaaaattg ctcgtattat 1380 aaattaccca gtttagaggg aaaaaaagaa aataattatt cctaaacaaa tggataagta 1440 gaattaatgg ttgaggcagg accctacaga gtgtgggaac tgctggggat ctagagaatt 1500 cagtgggacc aatgaaagca tggctgagaa atagcagggt agtccaggat agtctaaggg 1560 aggtgttccc atctgagccc agagataagg gtgtcttcct agaacattag ccgtagtgga 1620 attaacagga aatcatgagg gtgacgtaga attgagtctt ccaggggact ctatcagaac 1680 tggaccattt ccaagtatat aacgatgagc cctctaatgc taggagtagc aaatggtcct 1740 aggaagggga ctgaggattg gggtgggggt ggggtggaaa agaaagtaca gaacaaaccc 1800 tgtgtcactg tcccaagtta agctaagtga acagaactat ctcagcatca gaatgagaaa 1860 gcctgagaag aaagaaccaa ccacaagcac acaggaagga aagcgcagga ggtgaaaatg 1920 ctttcttggc cagggtagta agaattagag gttaatgcag ggactgtaaa accacctttt 1980 ctgcttcaat gtctagttcc tgtatagctt tgttcattgc atttattaaa caaatgttgt 2040 cactus cttcttcatg tcagttccaa tgaggtgggg atggagaaga caattgttgc ttatgaaaga 2160 aagctttagc tgtctctgtt ttgtaagctt tcagtgcaac atttcttggt tccaataaag 2220 cattttacaa gatcttgcat gctactctta gatagaagat ggcaaaacca tggtaataaa 2280 atatgaatga taaaaaaaaa 2300 <210> 62 <211> 430 <212> DNA <213> Homo sapiens <400> 62 gactgtcact cggtcccaga caccagagca agctcaagac ccagcagtgg gacagccaga 60 cagacggcac gatggcactg agctcccaga tctgggccgc ttgcctcctg ctcctcctcc 120 tcctcgccag cctgaccagt ggctctgttt tcccacaaca gacgggacaa cttgcagagc 180 tgcaacccca ggacagagct ggagccaggg ccagctggat gcccatgttc cagaggcgaa 240 ggaggcgaga cacccacttc cccatctgca ttttctgctg cggctgctgt catcgatcaa 300 agtgtgggat gtgctgcaag acgtagaacc tacctgccct gcccccgtcc cctcccttcc 360 ttatttattc ctgctgcccc agaacatagg tcttggaata aaatggctgg ttcttttgtt 420 ttccaaaaaa 430 <210> 63 <211> 948 <212> DNA <213> Homo sapiens <400> 63 cacacacctt aaccctgact ttttttgctc cagtttttca gaagaagtga agtcaagatg 60 aagaaccatt tgcttttctg gggagtcctg gcggttttta ttaaggctgt tcatgtgaaa 120 gcccaagaag atgaaaggat tgttcttgtt gacaacaaat gtaagtgtgc ccggattact 180 tccaggatca tccgttcttc cgaagatcct aatgaggaca ttgtggagag aaacatccga 240 attattgttc ctctgaacaa cagggagaat atctctgatc ccacctcacc attgagaacc 300 agatttgtgt accatttgtc tgacctctgt aaaaaatgtg atcctacaga agtggagctg 360 gataatcaga tagttactgc tacccagagc aatatctgtg atgaagacag tgctacagag 420 acctgctaca cttatgacag aaacaagtgc tacacagctg tggtcccact cgtatatggt 480 ggtgagacca aaatggtgga aacagcctta accccagatg cctgctatcc tgactaattt 540 aagtcattgc tgactgcata gctctttttc ttgagaggct ctccattttg attcagaaag 600 ttagcatatt tattaccaat gaatttgaaa ccagggcttt tttttttttt ttgggtgatg 660 taaaaccaac tccctgccac caaaataatt aaaatagtca cattgttatc tttattaggt 720 aatcacttct taattatatg ttcatactct aagtatcaaa atcttccaat tatcatgctc 780 acctgaaaga ggtatgctct cttaggaata cagtttctag cattaaacaa ataaacaagg 840 ggagaaaata aaactcaagg agtgaaaatc aggaggtgta ataaaatgtt cctcgcattc 900 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 948 <210> 64 <211> 1484 <212> DNA <213> Homo sapiens <400> 64 cccgtgagga ggaaaaggtg tgtccgctgc cacccagtgt gagcgggtga caccacccgg 60 ttaggaaatc ccagctccca agagggtata aatccctgct ttactgctga gctcctgctg 120 gaggtgaaag tctggcctgg cagccttccc caggtgagca gcaacaaggc cacgtgctgc 180 tgggtctcag tcctccactt cccgtgtcct ctggaagttg tcaggagcaa tgttgcgctt 240 gtacgtgttg gtaatgggag tttctgcctt cacccttcag cctgcggcac acacaggggc 300 tgccagaagc tgccggtttc gtgggaggca ttacaagcgg gagttcaggc tggaagggga 360 gcctgtagcc ctgaggtgcc cccaggtgcc ctactggttg tgggcctctg tcagcccccg 420 catcaacctg acatggcata aaaatgactc tgctaggacg gtcccaggag aagaagagac 480 acggatgtgg gcccaggacg gtgctctgtg gcttctgcca gccttgcagg aggactctgg 540 cacctacgtc tgcactacta gaaatgcttc ttactgtgac aaaatgtcca ttgagctcag 600 agtttttgag aatacagatg ctttcctgcc gttcatctca tacccgcaaa ttttaacctt 660 gtcaacctct ggggtattag tatgccctga cctgagtgaa ttcacccgtg acaaaactga 720 cgtgaagatt caatggtaca aggattctct tcttttggat aaagacaatg agaaatttct 780 aagtgtgagg gggaccactc acttactcgt acacgatgtg gccctggaag atgctggcta 840 ttaccgctgt gtcctgacat ttgcccatga aggccagcaa tacaacatca ctaggagtat 900 tgagctacgc atcaagaaaa aaaaagaaga gaccattcct gtgatcattt cccccctcaa 960 gaccatatca gcttctctgg ggtcaagact gacaatcccg tgtaaggtgt ttctgggaac 1020 cggcacaccc ttaaccacca tgctgtggtg gacggccaat gacacccaca tagagagcgc 1080 ctacccggga ggccgcgtga ccgaggggcc acgccaggaa tattcagaaa ataatgagaa 1140 ctacattgaa gtgccattga tttttgatcc tgtcacaaga gaggatttgc acatggattt 1200 taaatgtgtt gtccataata ccctgagttt tcagacacta cgcaccacag tcaaggaagc 1260 ctcctccacg ttctcctggg gcattgtgct ggccccactt tcactggcct tcttggtttt 1320 ggggggaata tggatgcaca gacggtgcaa acacagaact ggaaaagcag atggtctgac 1380 tgtgctatgg cctcatcatc aagactttca atcctatccc aagtgaaata aatggaatga 1440 aataattcaa acacaaaaaa aaaaaaaaaa aaaaaaaaaaaaaa 1484 <210> 65 <211> 2859 <212> DNA <213> Homo sapiens <400> 65 cattcagaga cagaaggtgg atagacaaat ctccaccttc agactggtag gctcctccag 60 aagccatcag acaggaagat gtgaaaatcc ccagcactca tcccagaatc actaagtggc 120 acctgtcctg ggccaaagtc ccaggacaga cctcattgtt cctctgtggg aatacctccc 180 caggagggca tcctggattt cccccttgca acccaggtca gaagtttcat cgtcaaggtt 240 gtttcatctt ttttttcctg tctaacagct ctgactacca cccaaccttg aggcacagtg 300 aagacatcgg tggccactcc aataacagca ggtcacagct gctcttctgg aggtgtccta 360 caggtgaaaa gcccagcgac ccagtcagga tttaagttta cctcaaaaat ggaagatttt 420 aacatggaga gtgacagctt tgaagatttc tggaaaggtg aagatcttag taattacagt 480 tacagctcta ccctgccccc ttttctacta gatgccgccc catgtgaacc agaatccctg 540 gaaatcaaca agtattttgt ggtcattatc tatgccctgg tattcctgct gagcctgctg 600 ggaaactccc tcgtgatgct ggtcatctta tacagcaggg tcggccgctc cgtcactgat 660 gtctacctgc tgaacctagc cttggccgac ctactctttg ccctgacctt gcccatctgg 720 gccgcctcca aggtgaatgg ctggattttt ggcacattcc tgtgcaaggt ggtctcactc 780 ctgaaggaag tcaacttcta tagtggcatc ctgctactgg cctgcatcag tgtggaccgt 840 tacctggcca ttgtccatgc cacacgcaca ctgacccaga agcgctactt ggtcaaattc 900 atatgtctca gcatctgggg tctgtccttg ctcctggccc tgcctgtctt acttttccga 960 aggaccgtct actcatccaa tgttagccca gcctgctatg aggacatggg caacaataca 1020 gcaaactggc ggatgctgtt acggatcctg ccccagtcct ttggcttcat cgtgccactg 1080 ctgatcatgc tgttctgcta cggattcacc ctgcgtacgc tgtttaaggc ccacatgggg 1140 cagaagcacc gggccatgcg ggtcatcttt gctgtcgtcc tcatcttcct gctctgctgg 1200 ctgccctaca acctggtcct gctggcagac accctcatga ggacccaggt gatccaggag 1260 acctgtgagc gccgcaatca catcgaccgg gctctggatg ccaccgagat tctgggcatc 1320 cttcacagct gcctcaaccc cctcatctac gccttcattg gccagaagtt tcgccatgga 1380 ctcctcaaga ttctagctat acatggcttg atcagcaagg actccctgcc caaagacagc 1440 aggccttcct ttgttggctc ttcttcaggg cacacttcca ctactctcta agacctcctg 1500 cctaagtgca gccccgtggg gttcctccct tctcttcaca gtcacattcc aagcctcatg 1560 tccactggtt cttcttggtc tcagtgtcaa tgcagccccc attgtggtca caggaagtag 1620 aggaggccac gttcttacta gtttcccttg catggtttag aaagcttgcc ctggtgcctc 1680 accccttgcc ataattacta tgtcatttgc tggagctctg cccatcctgc ccctgagccc 1740 atggcactct atgttctaag aagtgaaaat ctacactcca gtgagacagc tctgcatact 1800 cattaggatg gctagtatca aaagaaagaa aatcaggctg gccaacgggg tgaaaccctg 1860 tctctactaa aaatacaaaa aaaaaaaaaa attagccggg cgtggtggtg agtgcctgta 1920 atcacagcta cttgggaggc tgagatggga gaatcacttg aacccgggag gcagaggttg 1980 cagtgagccg agattgtgcc cctgcactcc agcctgagcg acagtgagac tctgtctcag 2040 tccatgaaga tgtagaggag aaactggaac tctcgagcgt tgctgggggg gattgtaaaa 2100 tggtgtgacc actgcagaag acagtatggc agctttcctc aaaacttcag acatagaatt 2160 aacacatgat cctgcaattc cacttatagg aattgaccca caagaaatga aagcagggac 2220 ttgaacccat atttgtacac caatattcat agcagcttat tcacaagacc caaaaggcag 2280 aagcaaccca aatgatcatc aatgaatgaa tgaatggcta agcaaaatgt gatatgtacc 2340 taacgaagta tccttcagcc tgaaagagga atgaagtact catacatgtt acaacacgga 2400 cgaaccttga aaactttatg ctaagtgaaa taagccagac atcaacagat aaatagttta 2460 tgattccacc tacatgaggt actgagagtg aacaaattta cagagacaga aagcagaaca 2520 gtgattacca gggactgagg ggaggggagc atgggaagtg acggtttaat gggcacaggg 2580 tttatgttta ggatgttgaa aaagttctgc agataaacag tagtgatagt tgtaccgcaa 2640 tgtgacttaa tgccactaaa ttgacactta aaaatggttt aaatggtcaa ttttgttatg 2700 tatattttat atcaatttaa aaaaaaacct gagccccaaa aggtatttta atcaccaagg 2760 ctgattaaac caaggctaga accacctgcc tatatttttt gttaaatgat ttcattcaat 2820 atcttttttt taataaacca tttttacttg ggtgtttat 2859 <210> 66 <211> 2129 <212> DNA <213> Homo sapiens <400> 66 acgtgatcca cccgcctcgg cctcccaaag tttttggatt acaggtgtga gccacctcgc 60 ccggtcctat ctctctttct tctctttctc cctctcactt tgtttctctt ctctctctct 120 ctcccgcctc cttcccccgt ctcccctccc ttccccccac cgccctcttc atagctgagc 180 ctgtccggca gtgcggcgga tgtacggatg attcagtggc tggcaggaag cccgccctgc 240 ccgcccgcca gtgtcagtgg tgttggcatc agcttgggca ggtgtgcggg ctcaggatgg 300 ggcggccgtg gtgaggaacc ctggactctc agagatggaa tttcaccgtg ttgcctaggc 360 tggtctggag ctcttgatct caagcgatcc tccctgcctc ggcctcccaa cgtgctggga 420 ttataggcgt gagccaccgc tcctggccag gcatcacaag aggcaacacc aggagccaac 480 atgagctcgg ggactgaact gctgtggccc ggagcagcgc tgctggtgct gttgggggtg 540 gcagccagtc tgtgtgtgcg ctgctcacgc ccaggtgcaa agaggtcaga gaaaatctac 600 cagcagagaa gtctgcgtga ggaccaacag agctttacgg ggtcccggac ctactccttg 660 gtcgggcagg catggccagg acccctggcg gacatggcac ccacaaggaa ggacaagctg 720 ttgcaattct accccagcct ggaggatcca gcatcttcca ggtaccagaa cttcagcaaa 780 ggaagcagac acgggtcgga ggaagcctac atagacccca ttgccatgga gtattacaac 840 tgggggcggt tctcgaagcc cccagaagat gatgatgcca attcctacga gaatgtgctc 900 atttgcaagc agaaaaccac agagacaggt gcccagcagg agggcatagg tggcctctgc 960 agaggggacc tcagcctgtc actggccctg aagactggcc ccacttctgg tctctgtccc 1020 tctgcctccc cggaagaaga tgaggaatct gaggattatc agaactcagc atccatccat 1080 cagtggcgcg agtccaggaa ggtcatgggg caactccaga gagaagcatc ccctggcccg 1140 gtgggaagcc cagacgagga ggacggggaa ccggattacg tgaatgggga ggtggcagcc 1200 acagaagcct agggcagacc aagaagaaag gagccaaggc aaagagggac cactgtgctc 1260 atggacccat cgctgccttc caaggaccat ttcccagagc tactcaactt ttaagcccct 1320 gccatggttg ctcctggaag gagaaccagc caccctgagg accacctggc catgcgtgca 1380 cagcctggga aaagacagtt actcacggga gctgcaggcc cgtcaccaag ccctctcccg 1440 acccaggctt tgtggggcag gcacctggta ccaagggtaa cccggctcct ggtatggacg 1500 gatgcgcagg atttaggata agctgtcacc cagtccccat aacaaaacca ctgtccaaca 1560 ctggtatctg tgttcttttg tgctatgaat ttggattcct aattgctatt gttggttgct 1620 ggggttttaa atgattgata agcttgtaca gttaacttat agagggggag ccatatttaa 1680 cattctggat ttcagagtag agatttctgt gttgtctcct agaaagcatt acatgtagtt 1740 tatttcagca tccttgttgg gtggggccct ggctctcttc ccctttggtg ggacctcccc 1800 tttctttggg cttcagttca ctcaggaaga aatgaggctg tcgccatctt tatgtgcttc 1860 cagtggaaat gtcacttgct acagacaata gtgcatgaga gtctagagaa gtagtgacca 1920 gaacagggca gagtaggtcc cctccatggc cctgaatcct cctctgctcc agggctggcc 1980 tctgcagagc tgattaaaca gtgttgtgac tgtctcatgg gaagagctgg ggcccagagg 2040 gaccttgagt cagaaatgtt gccagaaaaa gtatctcctc caaccaaaac atctcaataa 2100 aaccatttta gttgaaaagc aaaaaaaaa 2129 <210> 67 <211> 1696 <212> DNA <213> Homo sapiens <400> 67 ccgagtgtcc acaccctgtg cgtctctctg tcctgccagc actgagggct catccatccg 60 cagagcaggg cagtgggagg agacgccatg acccccatcc tcacggtcct gatctgtctc 120 gggctgagtc tgggccccag gacccacgtg caggcagggc acctccccaa gcccaccctc 180 tgggctgagc caggctctgt gatcatccag ggaagtcctg tgaccctcag gtgtcagggg 240 agccttcagg ctgaggagta ccatctatat agggaaaaca aatcagcatc ctgggttaga 300 cggatacaag agcctgggaa gaatggccag ttccccatcc catccatcac ctgggaacac 360 gcagggcggt atcactgtca gtactacagc cacaatcact catcagagta cagtgacccc 420 ctggagctgg tggtgacagg agcctacagc aaacccaccc tctcagctct gcccagccct 480 gtggtgacct taggagggaa cgtgaccctc cagtgtgtct cacaggtggc atttgacggc 540 ttcattctgt gtaaggaagg agaagatgaa cacccacaac gcctgaactc ccattcccat 600 gcccgtgggt ggtcctgggc catcttctcc gtgggccccg tgagcccgag tcgcaggtgg 660 tcgtacaggt gctatgctta tgactcgaac tctccctatg tgtggtctct acccagtgat 720 ctcctggagc tcctggtccc aggtgtttct aagaagccat cactctcagt gcagccaggt 780 cctatggtgg cccctgggga gagcctgacc ctccagtgtg tctctgatgt cggctacgac 840 agatttgttc tgtataagga gggagaacgt gacttcctcc agcgccctgg ttggcagccc 900 caggctgggc tctcccaggc caacttcacc ctgggccctg tgagcccctc ccacgggggc 960 cagtacagat gctacagtgc acacaacctc tcctccgagt ggtcggcccc cagtgacccc 1020 ctggacatcc tgatcacagg acagttctat gacagaccct ctctctcggt gcagccggtc 1080 cccacagtag ccccaggaaa gaacgtgacc ctgctgtgtc agtcacgggg gcagttccac 1140 actttccttc tgaccaagga gggggcaggc catcccccac tgcatctgag atcagagcac 1200 caagctcagc agaaccaggc tgaattccgc atgggtcctg tgacctcagc ccacgtgggg 1260 acctacagat gctacagctc actcagctcc aacccctacc tgctgtctct ccccagtgac 1320 cccctggagc tcgtggtctc agcatcccta ggccaacacc cccaggatta cacagtggag 1380 aatctcatcc gcatgggtgt ggctggcttg gtcctggtgg tcctcgggat tctgctattt 1440 gaggctcagc acagccagag aagcctacaa gatgcagccg ggaggtgaac agcagagagg 1500 acaatgcata cttcagcgtg gtggagcctc agggacagat ctgatgatcc caggaggctc 1560 tggaggacaa tctaggacct acattatctg gactgtatgc tggtcatttc tagagacagc 1620 aatcaatatt tgagtgtaag gaaactgtct ggggtgattc ctagaagatc attaaactgt 1680 ggtacatttt tttgtc 1696 <210> 68 <211> 1624 <212> DNA <213> Homo sapiens <400> 68 gtcctctgtc ctgccagcac cgagggctca tccatccaca gagcagtgca gtgggaggag 60 acgccatgac ctccatcctc acggtcctga tctgtctcgg gctgagcctg gaccccagga 120 cccacgtgca ggcagggccc ctccccaagc ccaccctctg ggctgagcca ggctctgtga 180 tcacccaagg gagtcctgtg accctcaggt gtcaggggag cctggagacg caggagtacc 240 atctatatag agaaaagaaa acagcactct ggattacacg gatcccacag gagcttgtga 300 agaagggcca gttccccatc ctatccatca cctgggaaca tgcagggcgg tattgctgta 360 tctatggcag ccacactgta ggcctctcag agagcagtga ccccctggag ctggtggtga 420 caggagccta cagcaaaccc accctctcag ctctgcccag ccctgtggtg acctcaggag 480 ggaatgtgac catccagtgt gactcacagg tggcatttga tggcttcatt ctgtgtaagg 540 aaggagaaga tgaacaccca caatgcctga actcccattc ccatgcccgt gggtcatccc 600 gggccatctt ctccgtgggc cccgtgagcc caagtcgcag gtggtcgtac aggtgctatg 660 gttatgactc gcgcgctccc tatgtgtggt ctctacccag tgatctcctg gggctcctgg 720 tcccaggtgt ttctaagaag ccatcactct cagtgcagcc gggtcctgtc gtggcccctg 780 gggagaagct gaccttccag tgtggctctg atgccggcta cgacagattt gttctgtaca 840 aggagtgggg acgtgacttc ctccagcgcc ctggccggca gccccaggct gggctctccc 900 aggccaactt caccctgggc cctgtgagcc gctcctacgg gggccagtac acatgctccg 960 gtgcatacaa cctctcctcc gagtggtcgg cccccagcga ccccctggac atcctgatca 1020 caggacagat ccgtgccaga cccttcctct ccgtgcggcc gggccccaca gtggcctcag 1080 gagagaacgt gaccctgctg tgtcagtcac agggagggat gcacactttc cttttgacca 1140 aggagggggc agctgattcc ccgctgcgtc taaaatcaaa gcgccaatct cataagtacc 1200 aggctgaatt ccccatgagt cctgtgacct cggcccacgc ggggacctac aggtgctacg 1260 gctcactcag ctccaacccc tacctgctga ctcaccccag tgaccccctg gagctcgtgg 1320 tctcaggagc agctgagacc ctcagcccac cacaaaacaa gtccgactcc aaggctggtg 1380 agtgaggaga tgcttgccgt gatgacgctg ggcacagagg gtcaggtcct gtcaagagga 1440 gctgggtgtc ctgggtggac atttgaagaa ttatattcat tccaacttga agaattattc 1500 aacaccttta acaatgtata tgtgaagtac tttattcttt catattttaa aaataaaaga 1560 taattatcca tgagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1620 aaaa 1624 <210> 69 <211> 2840 <212> DNA <213> Homo sapiens <400> 69 atgacaagaa ggacccagcc tccgagcggc cacaccctgt gtgtctctct gtcctgccag 60 cactgagggc tcatccctct gcagagcgcg gggtcaccgg gaggagacgc catgacgccc 120 gccctcacag ccctgctctg ccttgggctg agtctgggcc ccaggacccg cgtgcaggca 180 gggcccttcc ccaaacccac cctctgggct gagccaggct ctgtgatcag ctgggggagc 240 cccgtgacca tctggtgtca ggggagccag gaggcccagg agtaccgact gcataaagag 300 ggaagcccag agcccttgga cagaaataac ccactggaac ccaagaacaa ggccagattc 360 tccatcccat ccatgacaga gcaccatgca gggagatacc gctgccacta ttacagctct 420 gcaggctggt cagagcccag cgaccccctg gagatggtga tgacaggagc ctacagcaaa 480 cccaccctct cagccctgcc cagccctgtg gtggcctcag gggggaatat gaccctccga 540 tgtggctcac agaagggata tcaccatttt gttctgatga aggaaggaga acaccagctc 600 ccccggaccc tggactcaca gcagctccac agtcgggggt tccaggccct gttccctgtg 660 ggccccgtga cccccagcca caggtggagg ttcacatgct attactatta tacaaacacc 720 ccctgggtgt ggtcccaccc cagtgacccc ctggagattc tgccctcagg cgtgtctagg 780 aagccctccc tcctgaccct gcagggccct gtcctggccc ctgggcagag cctgaccctc 840 cagtgtggct ctgatgtcgg ctacaacaga tttgttctgt ataaggaggg ggaacgtgac 900 ttcctccagc gccctggcca gcagccccag gctgggctct cccaggccaa cttcaccctg 960 ggccctgtga gcccctccaa tgggggccag tacaggtgct acggtgcaca caacctctcc 1020 tccgagtggt cggcccccag cgaccccctg aacatcctga tggcaggaca gatctatgac 1080 accgtctccc tgtcagcaca gccgggcccc acagtggcct caggagagaa cgtgaccctg 1140 ctgtgtcagt catggtggca gtttgacact ttccttctga ccaaagaagg ggcagcccat 1200 cccccactgc gtctgagatc aatgtacgga gctcataagt accaggctga attccccatg 1260 agtcctgtga cctcagccca cgcggggacc tacaggtgct acggctcata cagctccaac 1320 ccccacctgc tgtctcaccc cagtgagccc ctggagctcg tggtctcagg acactctgga 1380 ggctccagcc tcccacccac agggccgccc tccacacctg gtctgggaag atacctggag 1440 gttttgattg gggtctcggt ggccttcgtc ctgctgctct tcctcctcct cttcctcctc 1500 ctccgacgtc agcgtcacag caaacacagg acatctgacc agagaaagac tgatttccag 1560 cgtcctgcag gggctgcgga gacagagccc aaggacaggg gcctgctgag gaggtccagc 1620 ccagctgctg acgtccagga agaaaacctc tatgctgccg tgaaggacac acagtctgag 1680 gacagggtgg agctggacag tcagagccca cacgatgaag acccccaggc agtgacgtat 1740 gccccggtga aacactccag tcctaggaga gaaatggcct ctcctccctc ctcactgtct 1800 ggggaattcc tggacacaaa ggacagacagga gtggaagagg acaggcagat ggacactgag 1860 gctgctgcat ctgaagcctc ccaggatgtg acctacgccc agctgcacag cttgaccctt 1920 agacggaagg caactgagcc tcctccatcc caggaagggg aacctccagc tgagcccagc 1980 atctacgcca ctctggccat ccactagccc ggggggtacg cagaccccac actcagcaga 2040 aggagactca ggactgctga aggcacggga gctgccccca gtggacacca gtgaacccca 2100 gtcagcctgg acccctaaca cagaccatga ggagacgctg ggaacttgtg ggactcacct 2160 gactcaaaga tgactaatat cgtcccattt tggaaataaa gcaacagact tctcaacaat 2220 caatgagtta ataacaaaaa aacaaaaaac aaaaacagac gtaaaggccg ggtgtggtac 2280 tcaggaggct gagtggggag gattccttga acacaagaag ttaaggctgc tgaggctgca 2340 gtgagctatg actgtgccac tgcactccag cctgtgtgac agagcgagac cttgtctcta 2400 aaaaaaaaaa cagtgaatgt tttaaactga atgataatgt aaatattata catcgaactt 2460 atgacatggg aaaattaaga agcataaata ggccgggcgc ggtggctcac gcctataatc 2520 tcagcacttt gggaggctga tgcgggcgga tcatgaggtc aggagatcga gaccatcctg 2580 gctaacacgg tgaaaccccg tctctactaa aaatacaaaa aaattagccg ggcgtggtgg 2640 cgagtgccta tagtcccagc tactcaggag gctgaggcag gagaatggca tgagcccggg 2700 aggcagagct tgcagtgagc tgagatcgca ccactgcact ccagcctggg cgacagagtg 2760 agattccgtc tcgaaaaaaa aaaaaaaaga aagaaaaaaa ataaaaaaga agcataacca 2820 ggaaaaaaaa aaaaaaaaaa 2840 <210> 70 <211> 650 <212> DNA <213> Homo sapiens <400> 70 aggctggggg agaagttaaa gccagaggag gggcaggaat gtctgaggtg gcaacacttc 60 tcttcagcca gacagcactg gccagtttgg agtctgtcca tcctgcaggc cacaagctct 120 ggatgaggaa cttgaggcaa gtcaccagcc cctgatcatt tcgcctaaaa gagcaaggac 180 tagagttcct gacctccagg ccagtccctg atccctgacc taatgttatc gcggaatgat 240 ggcccagggc tcctcagagc aggaactcca ctatgcatct ctgcagaggc tgccagtgcc 300 cagcagtgag ggacctgacc tcaggggcag agacaagaga ggcaccaagg aggatccaag 360 agctgactat gcctgcattg ctgagaacaa acccacctga gcaccccaga caccttcctc 420 aacccaggcg ggtggacagg gtccccctgt ggtccagcca gtaaaaacca tggtcccccc 480 acttctgtgt ctcagtcctc tcagtccatc tcgagcctcc gttcaaattg atcatcatca 540 aaacttatgt ggctttttga cctttgaata gggaattttt taaatttttt aaaaattaaa 600 ataaaaaaaa cacatggctc acccttccac ccaaaaaaaa aaaaaaaaaa 650 <210> 71 <211> 2136 <212> DNA <213> Homo sapiens <400> 71 gccctggagg cccggcctgg ccgctcccgg ccctggggtg cacatcggcc ctgagtcccg 60 tcccaggctc tgggctcggg cagccgccgc caccgctgcc caggacgtcg ggcctcctgc 120 cttcctccca ggcccccacg ttgctggccg cctggccgag tggccgccat gctcctgcct 180 tgggccacct ctgcccccgg cctggcctgg gggcctctgg tgctgggcct cttcgggctc 240 ctggcagcat cgcagcccca ggcggtgcct ccatatgcgt cggagaacca gacctgcagg 300 gaccaggaaa aggaatacta tgagccccag caccgcatct gctgctcccg ctgcccgcca 360 ggcacctatg tctcagctaa atgtagccgc atccgggaca cagtttgtgc cacatgtgcc 420 gagaattcct acaacgagca ctggaactac ctgaccatct gccagctgtg ccgcccctgt 480 gacccagtga tgggcctcga ggagattgcc ccctgcacaa gcaaacggaa gacccagtgc 540 cgctgccagc cgggaatgtt ctgtgctgcc tgggccctcg agtgtacaca ctgcgagcta 600 ctttctgact gcccgcctgg cactgaagcc gagctcaaag atgaagttgg gaagggtaac 660 aaccactgcg tcccctgcaa ggcagggcac ttccagaata cctcctcccc cagcgcccgc 720 tgccagcccc acaccaggtg tgagaaccaa ggtctggtgg aggcagctcc aggcactgcc 780 cagtccgaca caacctgcaa aaatccatta gagccactgc ccccagagat gtcaggaacc 840 atgctgatgc tggccgttct gctgccactg gccttctttc tgctccttgc caccgtcttc 900 tcctgcatct ggaagagcca cccttctctc tgcaggaaac tgggatcgct gctcaagagg 960 cgtccgcagg gagagggacc caatcctgta gctggaagct gggagcctcc gaaggcccat 1020 ccatacttcc ctgacttggt acagccactg ctacccattt ctggagatgt ttccccagta 1080 tccactgggc tccccgcagc cccagttttg gaggcagggg tgccgcaaca gcagagtcct 1140 ctggacctga ccagggagcc gcagttggaa cccggggagc agagccaggt ggcccacggt 1200 accaatggca ttcatgtcac cggcgggtct atgactatca ctggcaacat ctacatctac 1260 aatggaccag tactgggggg accaccgggt cctggagacc tcccagctac ccccgaacct 1320 ccatacccca ttcccgaaga gggggaccct ggccctcccg ggctctctac accccaccag 1380 gaagatggca aggcttggca cctagcggag acagagcact gtggtgccac accctctaac 1440 aggggcccaa ggaaccaatt tatcacccat gactgacgga gtctgagaaa aggcagaaga 1500 aggggggcac aagggcactt tctcccttga ggctgccctg cccacgtggg attcacaggg 1560 gcctgagtag ggcccgggga agcagagccc taagggatta aggctcagac acctctgaga 1620 gcaggtgggc actggctggg tacggtgccc tccacaggac tctccctact gcctgagcaa 1680 acctgaggcc tcccggcaga cccacccacc ccctggggct gctcagcctc aggcacggac 1740 agggcacatg ataccaactg ctgcccacta cggcacgccg caccggagca cggcaccgag 1800 ggagccgcca cacggtcacc tgcaaggacg tcacgggccc ctctaaagga ttcgtggtgc 1860 tcatccccaa gcttcagaga ccctttgggg ttccacactt cacgtggact gaggtagacc 1920 ctgcatgaag atgaaattat agggaggacg ctccttccct cccctcctag aggagaggaa 1980 agggagtcat taacaactag ggggttgggt aggattccta ggtatgggga agagttttgg 2040 aaggggagga aaatggcaag tgtatttata ttgtaaccac atgcaaataa aaagaatggg 2100 acctaaactc gtgccgctcg tgccgaattc ctgcag 2136 <210> 72 <211> 895 <212> DNA <213> Homo sapiens <400> 72 ttatttttct gtgtgtccca tacaggcccc caccatgaag ggtttcacag ccactctctt 60 cctctggact ctgatttttc ccagctgcag tggaggcggc ggtgggaaag cctggcccac 120 acacgtggtc tgtagcgaca gcggcttgga agtgctctac cagagttgcg atccattaca 180 agattttggc ttttctgttg aaaagtgttc caagcaatta aaatcaaata tcaacattag 240 atttggaatt attctgagag aggacatcaa agagcttttt cttgacctag ctctcatgtc 300 tcaaggctca tctgttttga atttctccta tcccatctgt gaggcggctc tgcccaagtt 360 ttctttctgt ggaagaagga aaggagagca gatttactat gctgggcctg tcaataatcc 420 tgaatttact attcctcagg gagaatacca ggttttgctg gaactgtaca ctgaaaaacg 480 gtccaccgtg gcctgtgcca atgctactat catgtgctcc tgactgtggc ctgtagcaaa 540 aatcacagcc agctgcatct cgtgggacct ccaagctcct ctgactgaac ctactgtggg 600 aggagaagca gctgatgaca gagagaggct ctacaaagaa gcgcccccaa agagtgcagc 660 tgctaatttt agtcccagga ccagacatcc ccagactcca cagatgtaat gaagtccccg 720 aatgtatctg tttctaagga gcctcttggc agtccttaag cagtcttgag ggtccatcct 780 ttttctctaa ttggtcgcct cccaccagac tcacctgctt ttcaactttt taggagtgct 840 tcctcacagt taccaagaat aaagaaagct ggccaccata aaaaaaaaaaaaaaa 895 <210> 73 <211> 1386 <212> DNA <213> Homo sapiens <400> 73 gccagactgg agagaagcag gcctgagcct ccccaaaggc agctcctggg gactcccagg 60 accacaggct gagacgagac gcagggtggc tggaggaagt gagaggtgaa ctcagcctgg 120 gactggctgg gcgagactct ccacctgctc cctgggacca tcgcccacca tggctgtggc 180 ccagcagctg cgggccgaga gtgactttga acagcttccg gatgatgttg ccatctcggc 240 caacattgct gacatcgagg agaagagagg cttcaccagc cactttgttt tcgtcatcga 300 ggtgaagaca aaaggaggat ccaagtacct catctaccgc cgctaccgcc agttccatgc 360 tttgcagagc aagctggagg agcgcttcgg gccagacagc aagagcagtg ccctggcctg 420 taccctgccc acactcccag ccaaagtcta cgtgggtgtg aaacaggaga tcgccgagat 480 gcggatacct gccctcaacg cctacatgaa gagcctgctc agcctgccgg tctgggtgct 540 gatggatgag gacgtccgga tcttctttta ccagtcgccc tatgactcag agcaggtgcc 600 ccaggcactc cgccggctcc gcccgcgcac ccggaaagtc aagagcgtgt ccccacaggg 660 caacagcgtt gaccgcatgg cagctccgag agcagaggct ctatttgact tcactggaaa 720 cagcaaactg gagctgaatt tcaaagctgg agatgtgatc ttcctcctca gtcggatcaa 780 caaagactgg ctggagggca ctgtccgggg agccacgggc atcttccctc tctccttcgt 840 gaagatcctc aaagacttcc ctgaggagga cgaccccacc aactggctgc gttgctacta 900 ctacgaagac accatcagca ccatcaagga catcgcggtg gaggaagatc tcagcagcac 960 tcccctattg aaagacctgc tggagctcac aaggcgggag ttccagagag aggacatagc 1020 tctgaattac cgggacgctg agggggatct ggttcggctg ctgtcggatg aggacgtagc 1080 gctcatggtg cggcaggctc gtggcctccc ctcccagaag cgcctcttcc cctggaagct 1140 gcacatcacg cagaaggaca actacagggt ctacaacacg atgccatgag ctgacggtgt 1200 ccctggagca gtgaggggac accagcaaaa accttcagct ctcagaggag attgggacca 1260 ggaaaacctg ggaggatggg cagacttcct gtctttgagg ctaatggacc cgtggggctt 1320 gtaatctgtc tctttctact atttacatct gatttaaata aaccattcca tctgaaaggg 1380 gcaaaa 1386 <210> 74 <211> 741 <212> DNA <213> Homo sapiens <400> 74 actgcctgca gaaccccagc ccgactttcc ctgcgcactg ggatcctgct ggaacctcag 60 ctgcaacatg agctccgcag ccaggtcccg cctcacccgc gccacccgcc aggagatgct 120 gttcttggcg ttgctgctcc tgccagttgt ggtcgccttc gccagagctg aagctgaaga 180 agatggggac ctgcagtgcc tgtgtgtgaa gaccacctcc caggtccgtc ccaggcacat 240 caccagcctg gaggtgatca aggccggacc ccactgcccc actgcccaac tcatagccac 300 gctgaagaat gggaggaaaa tttgcttgga tctgcaagcc ctgctgtaca agaaaatcat 360 taaggaacat ttggagagtt agctactagc tgcctaagtg tgcactttca atctaactgt 420 gaaagaatct tctgatgttt gtattatcct tcttatatta tattaacaaa ataaatcaag 480 ttgtggtata gtcaatctat ttcttaataa tactgcaaaa ataatgctga cacatcacaa 540 tttcatattt taaaatttcc agaattttaa gcaaaaagca ttatgaagga aggcttggtt 600 taataaagac tgattttgtt cagtgttata tgttagctga tacatatttg ttcatttatg 660 tgattgcagt actttatagc tacatattta ccttgaatgt tacaattagc ttgccaataa 720 atattagtag ctcttaagca t 741 <210> 75 <211> 690 <212> DNA <213> Homo sapiens <400> 75 ccgggcgctc ctagcggtct cccggcccct gccgccctgc cactatgtcc cgccgctcta 60 tgctgcttgc ctgggctctt cccagcctcc ttcgactcgg agcggctcag gagacagaag 120 acccggcctg ctgcagcccc atagtgcccc ggaacgagtg gaaggccctg gcatcagagt 180 gcgcccagca cctgagcctg cccttacgct atgtggtggt atcgcacacg gcgggcagca 240 gctgcaacac ccccgcctcg tgccagcagc aggcccggaa tgtgcagcac taccacatga 300 agacactggg ctggtgcgac gtgggctaca acttcctgat tggagaagac gggctcgtat 360 acgagggccg tggctggaac ttcacgggtg cccactcagg tcacttatgg aaccccatgt 420 ccattggcat cagcttcatg ggcaactaca tggatcgggt gcccacaccc caggccatcc 480 gggcagccca gggtctactg gcctgcggtg tggctcaggg agccctgagg tccaactatg 540 tgctcaaagg acaccgggat gtgcagcgta cactctctcc aggcaaccag ctctaccacc 600 tcatccagaa ttggccacac taccgctccc cctgaggccc tgctgatccg caccccattc 660 ctcccctccc atggccaaaa accccactgt 690 <210> 76 <211> 3314 <212> DNA <213> Homo sapiens <400> 76 gaattccggc aggcgcccat ggcgggctga gtcctgccca tgccctggtg gcctggaagc 60 ctgcatgggc gccgtgcaaa gatcaacgtt ttccagagga gcttttgggc tcatcactgg 120 cctggggagg gcttgacacg gggttcccac agcttgcccc acaccacctt cacacccaca 180 cacagcaggt ccccgcgggg ccggtgcagg ctgtggctgc ccgcgctgcg ctgttgctct 240 gtcccggctg gctggctccg agtgtggggc gctctgggcc ggggccgctg gggcgcgcac 300 agtggggtga caggcggcct ggctgcagaa acgttgcacc ggtgcctgag gtgggaggat 360 gtgatgacgc ggcccacgca gcgggaaccc aggcctttaa aaagcccagg aaacagcctc 420 agctcaagcg gtggctccac tggaggaaaa cacaccccgg tctcacatta aagaagccaa 480 actgtcggct tcaaagagaa aaggcaacat cctgtcacag gccatgctct ggcaaaaacc 540 cacagctccg gagcaagccc cagccccggc ccggccatac cagggcgtcc gtgtgaagga 600 gccagtgaag gaactgctga ggaggaagcg aggccacgcc agcagtgggg cagcacctgc 660 acctacggcg gtggtgctgc cccatcagcc cctggcgacc tacaccacag tgggtccttc 720 ctgcctggac atggaaggtt ctgtgtctgc agtgacagag gaggctgccc tgtgtgccgg 780 ctggctctcc cagcccaccc cggccaccct gcagcccctg gccccatgga caccttacac 840 cgagtatgtg ccccatgaag ctgtcagctg cccctactca gctgacatgt atgtgcagcc 900 cgtgtgcccc agctacacgg tggtggggcc ctcctcagtg ttggcctatg cctctccgcc 960 actcatcacc aatgtcacga caagaagctc cgccacgccc gcagtggggc ccccgctgga 1020 gggcccagag caccaggcac ccctcaccta tttcccgtgg cctcagcccc tttccacact 1080 acccacctcc accctgcagt accggcctcc ggccccagcc ctacctgggc cccagtttgt 1140 ccagctcccc atctctatcc cagagccagt ccttcaggac atggaagacc ccagaagagc 1200 cgccagctcg ttgaccatcg acaagctgct tttggaggaa gaggatagcg acgcctatgc 1260 gcttaaccac actctctctg tggaaggctt ttaggcgtgg ctcccacctg agtcctgttc 1320 cctgaaactg ggattttaaa atgagcctgg aattgagccc caggttcatg cttgtttgga 1380 gtagtcattt catgactact ctttctacgc acagctagaa ttgtagacct gtaaaccttc 1440 cttcccttct tccttcccct ccctccctca cttcctccct ctcccccatc cttccattct 1500 tcccctccct cccttcttcc tttccaaccc cttccttcct tttcctccct cccttccttc 1560 cctccttccc ttctcccttt ccaacccctt ccttcctttt cctccctccc ttccttccct 1620 ccttcccttc tccctttcct tctttacctc cctccctccc tcgcttcttc tctctttctt 1680 acttcttttt tcaattctgt tccattttgg gaggtaatta tagggatttt agcaataaca 1740 ttttatgtca aatgttgcca agtctgtggt ccatgggctt tcatttctgt cacatttcat 1800 ttcttggaaa aggcctcctt cctccagtgc ctgctgaacc atcttagggt cactcacacc 1860 ctctgtaatt ttaagatgta tgtggtggcc ggcgggaaga ccagccccga cagcacctcc 1920 tgagaaagtc agccaagggc ctaccctgat gccagagtcc ttgagctgtc agttcccaca 1980 gttgctcctt tgtttgctct tctcagcctc ggccagattt acagtccagg cagcaaaatc 2040 tcaaggcctg gggctcagag tagtaagggg tgggaagtgg gtggcaggga gaaaagaaca 2100 tcagggtggg tggggacagg ccagtgacga agagagggac agaggaggga tgggaacagg 2160 ctgtgcatct tagttggaga gaggggtgtg ggaggaagct tgagtttgat gcagggagga 2220 ggaaggctga ggaatgactt ggctccagat tacttggtta ttaagaagaa caataaacta 2280 aaggaaagca ttgcttgaag agatggtttt gctgctctcc ttgaggatac gtgcaaggga 2340 agttgggctg ttgtaaacag ggtgaagggt gtgtttggtc ggccatttct ctctcacctc 2400 taggccctct gctggtgctg tggaggccaa gaccccatta agcctaaagg tgatgggtcc 2460 tcgcctaggc ttagtgctac catgtgggtt ttgtttcttt ccttccttcc ttccttcctt 2520 ccttccttcc ttccttcctt ccttccttcc ttccttcctt ccttctttcc ttccttcctt 2580 ccttccttcc ttcctctctc tttctttctt ttttttggtt ttttttggga cggagtctca 2640 ctccattgcc caggctggag tacaatggtg cgatcttggc tcactgcacc tctgtctccc 2700 aagttcaagt gattctcctg cctgagcctc ccgagtagct gggattacag gtgcatgcca 2760 ccatgcctgg ctaatttttg tatttttagt agagacgggg tttcaccatg ttggccaggc 2820 tggtctcgaa ctcctgacct tgtgatccgc gcgcctcagc ctctcagagt gctgggatca 2880 caggcgtgag ccaccgcacc cagcctttta ccatgtgggt ttctttagtg tcttaaaagc 2940 gtccataagc caccattctg tggaaccaag gccccctcca cgcaaacacc ctccctcctg 3000 gggacctctg gagcctcagc cagaagtacc attaggttta attttaattt gttttgctgg 3060 agaaacatca ggtttgtagg agactgagtt gttagcaggt gtgcttagct cttgatagtg 3120 aacgtgtacc ttgggaactg gctcacccac ctgctaatag caccatcgtc actattaagc 3180 agacatttca gttggtagaa tccatgtaga agtcatggac ttttctggga aatgactttt 3240 ctgggaaatg acagtttctt tgacatattt tctttgccca ctttaaataa aaactctgga 3300 gaaaaaaaaa aaaa 3314 <210> 77 <211> 3431 <212> DNA <213> Homo sapiens <400> 77 ggttttcagg agcccgagcg agggcgccgc ttttgcgtcc gggaggagcc aaccgtggcg 60 caggcggcgc ggggaggcgt cccagagtct cactctgccg cccaggctgg actgcagtga 120 cacaatctcg gctgactgca accactgcct ccagggttca agcgattctc ttgcctcagc 180 ctcccaagta gctgggatta cagattgatg ttcatgttcc tgacactact acaagattca 240 tactcctgat gctactgaca acgtggcttc tccacagtca ccaaaccagg gatgctatac 300 tggacttccc tactctcatc tgctccagcc ccctgacctt atagttgccc agctttcctg 360 gcaattgact ttgcccatca atacacagga tttagcatcc agggaagatg tcggagcctc 420 agatgttaat tttctaattg agaatgttgg cgctgtccga acctggagac aggaaaacaa 480 aaagtccttt ctcctgattc accaaaaaat aaaatactga ctaccatcac tgtgatgaga 540 ttcctatagt ctcaggaact gaagtcttta aacaaccagg gaccctctgc ccctagaata 600 agaacatact agaagtccct tctgctagga caacgaggat catgggagac cacctggacc 660 ttctcctagg agtggtgctc atggccggtc ctgtgtttgg aattccttcc tgctcctttg 720 atggccgaat agccttttat cgtttctgca acctcaccca ggtcccccag gtcctcaaca 780 ccactgagag gctcctgctg agcttcaact atatcaggac agtcactgct tcatccttcc 840 cctttctgga acagctgcag ctgctggagc tcgggagcca gtataccccc ttgactattg 900 acaaggaggc cttcagaaac ctgcccaacc ttagaatctt ggacctggga agtagtaaga 960 tatacttctt gcatccagat gcttttcagg gactgttcca tctgtttgaa cttagactgt 1020 atttctgtgg tctctctgat gctgtattga aagatggtta tttcagaaat ttaaaggctt 1080 taactcgctt ggatctatcc aaaaatcaga ttcgtagcct ttaccttcat ccttcatttg 1140 ggaagttgaa ttccttaaag tccatagatt tttcctccaa ccaaatattc cttgtatgtg 1200 aacatgagct cgagccccta caagggaaaa cgctctcctt ttttagcctc gcagctaata 1260 gcttgtatag cagagtctca gtggactggg gaaaatgtat gaacccattc agaaacatgg 1320 tgctggagat actagatgtt tctggaaatg gctggacagt ggacatcaca ggaaacttta 1380 gcaatgccat cagcaaaagc caggccttct ctttgattct tgcccaccac atcatgggtg 1440 ccgggtttgg cttccataac atcaaagatc ctgaccagaa cacatttgct ggcctggcca 1500 gaagttcagt gagacacctg gatctttcac atgggtttgt cttctccctg aactcacgag 1560 tctttgagac actcaaggat ttgaaggttc tgaaccttgc ctacaacaag ataaataaga 1620 ttgcagatga agcattttac ggacttgaca acctccaagt tctcaatttg tcatataacc 1680 ttctggggga actttacagt tcgaatttct atggactacc taaggtagcc tacattgatt 1740 tgcaaaagaa tcacattgca ataattcaag accaaacatt caaattcctg gaaaaattac 1800 agaccttgga tctccgagac aatgctctta caaccattca ttttattcca agcatacccg 1860 atatcttctt gagtggcaat aaactagtga ctttgccaaa gatcaacctt acagcgaacc 1920 tcatccactt atcagaaaac aggctagaaa atctagatat tctctacttt ctcctacggg 1980 tacctcatct ccagattctc attttaaatc aaaatcgctt ctcctcctgt agtggagatc 2040 aaaccccttc agagaatccc agcttagaac agcttttcct tggagaaaat atgttgcaac 2100 ttgcctggga aactgagctc tgttgggatg tttttgaggg actttctcat cttcaagttc 2160 tgtatttgaa tcataactat cttaattccc ttccaccagg agtatttagc catctgactg 2220 cattaagggg actaagcctc aactccaaca ggctgacagt tctttctcac aatgatttac 2280 ctgctaattt agagatcctg gacatatcca ggaaccagct cctagctcct aatcctgatg 2340 tatttgtatc acttagtgtc ttggatataa ctcataacaa gttcatttgt gaatgtgaac 2400 ttagcacttt tatcaattgg cttaatcaca ccaatgtcac tatagctggg cctcctgcag 2460 acatatattg tgtgtaccct gactcgttct ctggggtttc cctcttctct ctttccacgg 2520 aaggttgtga tgaagaggaa gtcttaaagt ccctaaagtt ctcccttttc attgtatgca 2580 ctgtcactct gactctgttc ctcatgacca tcctcacagt cacaaagttc cggggcttct 2640 gttttatctg ttataagaca gcccagagac tggtgttcaa ggaccatccc cagggcacag 2700 aacctgatat gtacaaatat gatgcctatt tgtgcttcag cagcaaagac ttcacatggg 2760 tgcagaatgc tttgctcaaa cacctggaca ctcaatacag tgaccaaaac agattcaacc 2820 tgtgctttga agaaagagac tttgtcccag gagaaaaccg cattgccaat atccaggatg 2880 ccatctggaa cagtagaaag atcgtttgtc ttgtgagcag acacttcctt agagatggct 2940 ggtgccttga agccttcagt tatgcccagg gcaggtgctt atctgacctt aacagtgctc 3000 tcatcatggt ggtggttggg tccttgtccc agtaccagtt gatgaaacat caatccatca 3060 gaggctttgt acagaaacag cagtatttga ggtggcctga ggatctccag gatgttggct 3120 ggtttcttca taaactctct caacagatac taaagaaaga aaaagaaaag aagaaagaca 3180 ataacattcc gttgcaaact gtagcaacca tctcctaatc aaaggagcaa tttccaactt 3240 atctcaagcc acaaataact cttcactttg tatttgcacc aagttatcat tttggggtcc 3300 tctctggagg tttttttttt ctttttgcta ctatgaaaac aacataaatc tctcaatttt 3360 cgtatcaaca ccatgttctg tctcactaac ctccaaatgg aaaataatag atctagaaaa 3420 ttgcaactgc c 3431 <210> 78 <211> 948 <212> DNA <213> Homo sapiens <400> 78 attgtggtgc cttgtagctg tcccgggagc cctcagcagc agttggagct ggtgcacagg 60 aaggatgagg aagaccaggc tctgggggct gctgtggatg ctctttgtct cagaactccg 120 agctgcaact aaattaactg aggaaaagta tgaactgaaa gaggggcaga ccctggatgt 180 gaaatgtgac tacacgctag agaagtttgc cagcagccag aaagcttggc agataataag 240 ggacggagag atgcccaaga ccctggcatg cacagagagg ccttcaaaga attcccatcc 300 agtccaagtg gggaggatca tactagaaga ctaccatgat catggtttac tgcgcgtccg 360 aatggtcaac cttcaagtgg aagattctgg actgtatcag tgtgtgatct accagcctcc 420 caaggagcct cacatgctgt tcgatcgcat ccgcttggtg gtgaccaagg gtttttcagg 480 gacccctggc tccaatgaga attctaccca gaatgtgtat aagattcctc ctaccaccac 540 taaggccttg tgcccactct ataccagccc cagaactgtg acccaagctc cacccaagtc 600 aactgccgat gtctccactc ctgactctga aatcaacctt acaaatgtga cagatatcat 660 cagggttccg gtgttcaaca ttgtcattct cctggctggt ggattcctga gtaagagcct 720 ggtcttctct gtcctgtttg ctgtcacgct gaggtcattt gtaccctagg cccacgaacc 780 cacgagaatg tcctctgact tccagccaca tccatctggc agttgtgcca agggaggagg 840 gaggaggtaa aaggcaggga gttaataaca tgaattaaat ctgtaatcac cagctatttc 900 taaagtcagc gtctcacctt aaaaaaaaaa aaaaaaaaaaaaaaaaaa 948 <210> 79 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 79 cctcaagagt gtgggtgaga c 21 <210> 80 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 80 tccttattgg ccttaagaag agc 23 <210> 81 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 81 tcggatgcta acctctaccg 20 <210> 82 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 82 gtctgggtcc ccatccat 18 <210> 83 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 83 gaggctggga ttccgttc 18 <210> 84 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 84 ttttctgtac ctttgtgtca acg 23 <210> 85 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 85 ttcctcctct tccacctcct 20 <210> 86 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 86 acaaacacat acagaataaa ccaagg 26 <210> 87 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 87 ctcatacgat ctgggcatga 20 <210> 88 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 88 gggaactctc agggaactca 20 <210> 89 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 89 tacgcaccac agtcaaggaa 20 <210> 90 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 90 aagaaggcca gtgaaagtgg 20 <210> 91 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 91 tcagcaccat caaggacatc 20 <210> 92 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 92 cagagctatg tcctctctct gga 23 <210> 93 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 93 ctgaaatcaa ccttacaaat gtgac 25 <210> 94 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 94 gctcttactc aggaatccac ca 22 <210> 95 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 95 gaggcacagt gaagacatcg 20 <210> 96 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 96 aggacacctc cagaagagca 20 <210> 97 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 97 tgcatacctt gtcaacttcg at 22 <210> 98 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 98 cctttcactg aattggtcac ac 22 <210> 99 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 99 ccctcaggga cttgctcag 19 <210> 100 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 100 ctccagcctc tggataggaa 20 <210> 101 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 101 ggcattttga agaattggaa ag 22 <210> 102 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 102 tttggatgct ctggtcatct t 21 <210> 103 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 103 gactgagttg atttctgtgt ctgaa 25 <210> 104 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 104 acacctcgtc aaactcctca g 21 <210> 105 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 105 ttggcaccta acgtgctg 18 <210> 106 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 106 ttcgtaccac tgagacatcc tg 22 <210> 107 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 107 accttcaaca tgaaagtctc tgc 23 <210> 108 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 108 ggacgttgag tgcatctgg 19 <210> 109 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 109 ggtgaggtca gcttcacatt c 21 <210> 110 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 110 ggttaattcc gtggcctaga 20 <210> 111 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 111 acgggaagac aaggtggac 19 <210> 112 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 112 tgcctgaggc ttctcttcac 20 <210> 113 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 113 gatgagtaca aaagtcctga tcca 24 <210> 114 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 114 ctgcagccac tggttctgt 19 <210> 115 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 115 agacagcaga gcacacaagc 20 <210> 116 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 116 atggttcctt ccggtgg 17 <210> 117 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 117 aaagctccca cttgaaagca 20 <210> 118 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 118 ccttcccatg agcatctgta a 21 <210> 119 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 119 tgaaatcttc caagtccaag g 21 <210> 120 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 120 ttccaaagac attttgacca gtt 23 <210> 121 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 121 gctggcagaa ctccgaga 18 <210> 122 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 122 ttttcagggg gtggactg 18 <210> 123 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 123 ggcattttga agaattggaa ag 22 <210> 124 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 124 tttggatgct ctggtcatct t 21 <210> 125 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 125 cagagcccat gctcaacc 18 <210> 126 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 126 acatcctttc tgccaactgc 20 <210> 127 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 127 tacgcaccac agtcaaggaa 20 <210> 128 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 128 aagaaggcca gtgaaagtgg 20 <210> 129 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 129 acgggaagac aaggtggac 19 <210> 130 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 130 tgcctgaggc ttctcttcac 20 <210> 131 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 131 gaggcacagt gaagacatcg 20 <210> 132 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 132 aggacacctc cagaagagca 20 <210> 133 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 133 agacagcaga gcacacaagc 20 <210> 134 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 134 atggttcctt ccggtggt 18 <210> 135 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 135 aaagctccca cttgaaagca 20 <210> 136 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 136 ccttcccatg agcatctgta a 21 <210> 137 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 137 tgaaatcttc caagtccaag g 21 <210> 138 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 138 ttccaaagac attttgacca gtt 23 <210> 139 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 139 tgctaaaact gcagaatctg gt 22 <210> 140 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 140 agctgggatt cactcagttt g 21 <210> 141 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 141 gctggcagaa ctccgaga 18 <210> 142 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 142 ttttcagggg gtggactg 18 <210> 143 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 143 gcattttgaa gaattggaaa g 21 <210> 144 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 144 tttggatgct ctggtcatct t 21 <210> 145 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 145 ggtgaggtca gcttcacatt c 21 <210> 146 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 146 ggttaattcc gtggcctaga 20 <210> 147 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 147 ctgttttctc acaacagacg 20 <210> 148 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> primer <400> 148 tctggaacat gggcatcc 18

Claims (5)

Genome for diagnosis of asthma and atopy containing genome bioindicators in human peripheral blood selected as shown in Table 1 in which gene expression changes in asthma and atopic disease as an active ingredient Biomarkers: A diene chip for the diagnosis of asthma and atopy, comprising one or more probes for a dielectric bioindicator according to claim 1 on a substrate. 3. The method of claim 2, Wherein the probe is selected from oligonucleotides having the nucleotide sequences of SEQ ID NOS: 79 to 148. An RT-PCR kit for the detection of formaldehyde exposure, comprising at least one primer capable of amplifying the genomic bioassay according to claim 1. 5. The method of claim 4, Wherein the primer is selected from oligonucleotides having the nucleotide sequences of SEQ ID NOS: 79 to 148.

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