KR101507301B1 - Adhesive hydrogel transdermal composition and method for preparing an adhesive hydrogel transdermal sheet using the same - Google Patents

Abstract

The present invention relates to a tacky hydrogel composition and a method for producing a tacky hydrogel sheet using the same. More particularly, the present invention relates to a tacky hydrogel sheet comprising a gelled polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a crosslinking agent, Mixing the composition, and the gelled polymer, the skin active ingredient, and the solvent at a temperature of 60 to 80 캜; Preparing a gel by adding a hydrophilic polymer, a polyhydric alcohol, a gelation rate regulator, and a crosslinking agent; And coating the gel on a support. The present invention also relates to a method for producing a sticky hydrogel sheet.
Generally, in the case of a skin patch with a hydrophilic polymer, a step of aging under heating conditions is required for sufficient crosslinking. However, the adhesive hydrogel composition of the present invention containing a hydrophilic polymer together with a gel polymer is not required to have stable tackiness A hydrogel sheet can be produced.

Description

TECHNICAL FIELD The present invention relates to a tacky hydrogel composition and a method for producing the tacky hydrogel sheet using the tacky hydrogel composition.

The present invention relates to a tacky hydrogel composition and a method for producing a tacky hydrogel sheet using the tacky hydrogel composition.

A hydrogel is a material having a three-dimensional hydrophilic polymer network structure using purified water as a dispersion medium and capable of absorbing a large amount of water and has the same flexibility as a natural tissue. Due to these characteristics, application fields such as wound dressings, contact lenses, medicines or cosmetic delivery media, implants, wastewater treatment agents and the like have been diversified.

In addition, hydrogels have the advantage of being able to add new functions such as controlled release, which can control the delivery of the substances contained therein, and pH, temperature, electric field, and irritation that is stimulated by light, have.

Hydrogels with these properties have a structure similar to that of the human body and are widely used in a variety of pharmaceutical industries as well as cosmetics and medical care since they have inert biocompatibility, rubber-like elasticity and excellent permeability of oxygen and nutrients .

In recent years, mask packs having improved moisturizing, nutritional supply, or exfoliation effects by utilizing elasticity, skin adhesion, and soft touch of such hydrogels have been developed.

However, the conventional hydrogel is changed into a fluid state as the temperature rises, and as a result, the hydrogel has a flowability, and there is a problem that adherence is somewhat deteriorated when the hydrogel is attached to the face.

Accordingly, one aspect of the present invention is to provide a stable tacky hydrogel composition having excellent adhesion.

Another aspect of the present invention is to provide a method for producing a stable tacky hydrogel sheet having excellent adhesion.

Accordingly, another aspect of the present invention is to provide a stable adhesive hydrogel sheet having excellent adhesion and produced by the above production method.

According to one aspect of the present invention, there is provided a sticky hydrogel composition comprising a gelated polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a cross-linking agent, a gelation rate regulator and a solvent.

The adhesive hydrogel composition comprises 0.1 to 10 wt% of a gelled polymer, 0.1 to 15 wt% of a skin active ingredient, 5 to 35 wt% of a polyhydric alcohol, 0.5 to 10 wt% of a hydrophilic polymer, 0.01 to 5 wt% of a crosslinking agent, 0.01 By weight to 5% by weight and the solvent is 45 to 80% by weight.

It is preferable that the gelated polymer is at least one selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, algin, carrageenan, xanthan and gellan.

The skin active ingredient is preferably at least one selected from the group consisting of arbutin, niacinamide, vitamin C, vitamin B5, vitamin E, retinol, coenzyme Q10, adenosine, elastin, collagen, hyaluronic acid, chitosan, Do.

The natural extract may be selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucilage, kakaduplum, camucam, yashiyaki, squalane, caviar, broccoli, , Acerola, Chlorella, Mangosteen, Guava, Mountain Demand, Carrots, Caffeine, Hamamelis, Spirulina, Salmon roe, Gamut, Giant kelp, Packo, Matsushiro, Parake, Mugwort, Mulberry root, Raspberry, Raspberry, It is preferably at least one selected from the group consisting of egg yolk, edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, golden oyster, alder tree, citron, albumin and egg yolk protein.

The polyhydric alcohol is preferably at least one selected from the group consisting of glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, and xylitol.

Wherein the hydrophilic polymer is selected from the group consisting of gelatin, polyacrylate or a salt thereof, polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone, methylcellulose, cellulose. Carboxymethylcellulose, and hydroxyethylcellulose, and more preferably at least one selected from the group consisting of carboxymethylcellulose, carboxymethylcellulose, and hydroxyethylcellulose.

The gelling rate regulator is preferably at least one selected from the group consisting of EDTA, acetic acid, lactic acid, oxalic acid, citric acid, tartaric acid, EDTA-2 sodium, calcium citrate, sodium citrate and sodium nitrate.

According to another aspect of the present invention, there is provided a method for producing a skin gel, comprising: mixing a gelled polymer, a skin active ingredient, and a solvent at a temperature of 60 to 80 캜; Preparing a gel by adding a hydrophilic polymer, a polyhydric alcohol, a gelation rate regulator, and a crosslinking agent; And coating the gel on a support. The present invention also provides a method for producing a sticky hydrogel sheet.

The adhesive hydrogel composition comprises 0.1 to 10 wt% of a gelled polymer, 0.1 to 15 wt% of a skin active ingredient, 5 to 35 wt% of a polyhydric alcohol, 0.5 to 10 wt% of a hydrophilic polymer, 0.01 to 5 wt% of a crosslinking agent, 0.01 By weight to 5% by weight and the solvent is 45 to 80% by weight.

The sheet is preferably produced to a thickness of 0.5 to 30 mm.

It is preferable that the support is selected from the group consisting of paper, nonwoven fabric, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polyethylene, polypropylene, polybutadiene, ethylene vinyl acetate copolymer and polyvinyl chloride film.

According to another aspect of the present invention, there is provided a tacky hydrogel sheet produced by the above-described production method.

Generally, in the case of a skin patch with a hydrophilic polymer, a step of aging under heating conditions is required for sufficient crosslinking. However, the adhesive hydrogel composition of the present invention comprising a hydrophilic polymer together with a gel polymer has no adhering force It is possible to produce an excellent and stable tacky hydrogel sheet.

Figure 1 shows the results (a) of Example 1 and the results (b) of Comparative Example 1 immediately after coating.
Fig. 2 shows the results (a) of Example 1 and the results (b) of Comparative Example 1 after 24 hours.
Fig. 3 shows the results (a) of Example 1 and the results (b) of Comparative Example 1 after 48 hours.

Hereinafter, the present invention will be described in detail.

The present invention relates to a sticky hydrogel composition comprising a gelled polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a cross-linking agent, a gelation rate regulator and a solvent. The present invention relates to a sticky hydrogel composition containing a hydrophilic polymer together with a gelled polymer, A stable tacky hydrogel sheet can be produced.

The adhesive hydrogel composition comprises 0.1 to 10 wt% of a gelled polymer, 0.1 to 15 wt% of a skin active ingredient, 5 to 35 wt% of a polyhydric alcohol, 0.5 to 10 wt% of a hydrophilic polymer, 0.01 to 5 wt% of a crosslinking agent, 0.01 By weight to 10% by weight and the solvent is 45 to 80% by weight.

More preferably, the adhesive hydrogel composition of the present invention comprises 0.5 to 5% by weight of a gelled polymer, 0.15 to 5% by weight of a skin active ingredient, 10 to 30% by weight of a polyhydric alcohol, 1 to 5% by weight of a hydrophilic polymer, 0.05 to 3% by weight of a gelling rate modifier, and 45 to 70% by weight of a solvent.

The gelling polymer contained in the adhesive hydrogel composition of the present invention acts to gelate the adhesive composition. For example, the gelling polymer may be selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, , Gellan and the like, but is not limited thereto.

The gelling polymer is preferably contained in an amount of 0.1 to 10% by weight, more preferably 0.5 to 5% by weight, based on the weight of the total adhesive hydrogel composition of the present invention. When the gel polymer is contained in an amount of less than 0.1% by weight, the hardness of the gel is low, flexibility is low, and skin adhesion is reduced, so that it is difficult to apply the gel to a skin having many bends. When the gel polymer is contained in an amount exceeding 10% There is a problem that the gel is stretched to make it difficult to maintain its shape, its elasticity is low, and its adhesive function is deteriorated.

The skin active ingredient contained in the skin adhesive composition of the present invention improves the affinity with the skin and enhances the skin absorption rate of the functional ingredient that can effectively act on the skin. The whitening ingredient, wrinkle function, antioxidant ingredient, Component, an antibacterial component, and the like, but is not limited thereto.

Skin active ingredients that may be included in the viscous hydrogel composition of the present invention include, for example, arbutin, niacinamide, vitamin C, vitamin B5, vitamin E, retinol, coenzyme Q10, adenosine, elastin, collagen, hyaluronic acid, chitosan, Extract, and the like, but the present invention is not limited thereto.

The natural extract may be selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, ginkgo leaf, propolis, mulberry leaf, silkworm, snail mucilage, kakaduplum, camucam, yashiyaki, squalane, caviar, broccoli, , Acerola, Chlorella, Mangosteen, Guava, Mountain Demand, Carrots, Caffeine, Hamamelis, Spirulina, Salmon roe, Gamut, Giant kelp, Packo, Matsushiro, Parake, Mugwort, Mulberry root, Raspberry, Raspberry, It is preferably at least one selected from the group consisting of egg yolk, edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, golden oyster, alder tree, citron, albumin and egg yolk protein.

The skin active ingredient may be added in an amount of 0.1 to 15% by weight, more preferably 0.15 to 5% by weight, based on the total adhesive hydrogel composition of the present invention. When the skin active ingredient is added in an amount of less than 0.1% by weight, the skin-affinity is poor and the effect of improving skin is insufficient. When the skin active ingredient is added in an amount exceeding 15% by weight, skin irritation may occur, There is a problem that the coloring and discoloration occurs.

The polyhydric alcohol contained in the skin sticking composition of the present invention has a moisturizing function and is, for example, a polyhydric alcohol which is composed of glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol and xylitol But it is not limited thereto. More preferably, glycerin is used.

The polyhydric alcohol is preferably added in an amount of 5 to 35% by weight, more preferably 10 to 30% by weight based on the total adhesive hydrogel composition of the present invention. When the amount of the polyhydric alcohol is less than 5% by weight, the moisture in the composition tends to be volatilized when adhering to the skin, resulting in deterioration of the adhesive strength. When the content is more than 35% by weight, stickiness, there is a problem.

The hydrophilic polymer is added for gelation, and any polymer capable of being gelled by water may be added. For example, gelatin, polyacrylate or a salt thereof, polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, But is not limited to, at least one member selected from the group consisting of polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone, methylcellulose, cellulose, carboxymethylcellulose, and hydroxyethylcellulose , And the salt of the polyacrylate is preferably a metal salt such as lithium, sodium or potassium.

The hydrophilic polymer may be contained in an amount of 0.5 to 10% by weight, more preferably 1 to 5% by weight based on the total adhesive hydrogel composition of the present invention. When the hydrophilic polymer is contained in an amount of less than 0.5% by weight, the pressure-sensitive adhesive hydrogel composition of the present invention tends not to maintain sufficient strength. When the hydrophilic polymer is contained in an amount of more than 10% by weight, the viscosity becomes high, There is a problem that the workability is insufficient due to high viscosity at the time of use.

The crosslinking agent is preferably a polyvalent metal salt, and examples thereof include aluminum hydroxide, aluminum hydroxide gel, hydrated aluminum silicate, kaolin, aluminum acetate, aluminum lactate, aluminum stearate, calcium chloride, magnesium chloride, magnesium aluminum metasilicate , And magnesium aluminosilicate, but the present invention is not limited thereto. Most preferably aluminum hydroxide can be used.

The crosslinking agent is preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight, most preferably 0.05 to 0.2% by weight based on the total adhesive hydrogel composition of the present invention.

When the amount of the crosslinking agent is less than 0.01% by weight, the crosslinking reaction does not sufficiently proceed and the gel strength tends to become insufficient. When the amount of the crosslinking agent is more than 5% by weight, the crosslinking reaction speed is excessively accelerated during the production of the adhesive- The strength of the viscous hydrogel composition becomes strong and the workability tends to become insufficient.

At this time, the gelling rate controlling agent may be, for example, an organic acid such as EDTA, acetic acid, lactic acid, oxalic acid, citric acid or tartaric acid having a chelating action with respect to metal ion, an organic acid such as EDTA-2 sodium, calcium citrate, sodium citrate or sodium nitrate , And an organic base. However, the present invention is not limited thereto.

On the other hand, the solvent of the present invention preferably uses water but is not limited thereto. The solvent is added in an amount of 100% by weight, and more preferably 45% by weight to 80% by weight, with the solvent added to the other components except for the solvent.

Further, other additives such as preservatives, perfumes, surfactants, thickeners and the like may be added to the adhesive hydrogel composition of the present invention, and the other additives are not particularly limited.

For example, the preservative added to the present invention may be selected from the group consisting of capryl glycols, paraoxybenzoic acid alkyl esters, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, phenoxyethanol, parabens, pentanediol, benzoic acid, salicylic acid, Its salt, ethylhexyl glycerin, 1,2-hexanediol, capryl glycol tropolone, p-oxybenzoic acid ester, 3-trifluoromethyl-4,4'-dichlorocarbabanilide, - trichloro-2-hydroxydiphenyl ether, but the present invention is not limited thereto.

According to the present invention, there is provided a process for producing a sticky hydrogel sheet, comprising mixing the gelled polymer, the skin active ingredient and the solvent at a temperature of 60 to 80 캜; Preparing a gel by adding a hydrophilic polymer, a polyhydric alcohol, a gelation rate regulator, and a crosslinking agent; And

And coating the gel on a support.

The components and content of the adhesive hydrogel composition used for producing the adhesive hydrogel sheet of the present invention are as described above.

The mixing at the temperature of 60 to 80 ° C may be carried out by adding other additives if necessary.

If the mixing step is carried out at a temperature of less than 60 캜, sufficient gelation is not achieved. If the mixing step is performed at a temperature higher than 80 캜, the stability of the skin active ingredient is reduced.

In the mixing step, a hydrophilic polymer, a polyhydric alcohol, a crosslinking agent, and a gelation rate controlling agent are then added to prepare a gel.

Further, other additives such as a preservative, a perfume, a surfactant, a thickening agent and the like may be further added to the adhesive hydrogel composition of the present invention as needed, and the other additives are not particularly limited.

In the step of coating the gel on a support, the coating may be carried out using any coating method well known in the art, for example, by coating with a roller and a film coater A solution casting method using a melt-extrusion method in which a film is obtained by extrusion, a solution casting method in which the cosmetic film composition is made into a dope, and the dope is cast to obtain a film.

In the coating step, the support may be paper, a nonwoven fabric, or a base material or a release film of various materials. Examples of the support include polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polyethylene, polypropylene, polybutadiene , Ethylene-vinyl acetate copolymer, and polyvinyl chloride film.

On the other hand, if necessary, the coated back surface may be coated with a nonwoven fabric, a paper, a film or the like on which the peeling treatment has been performed to prevent evaporation of moisture and the like.

The viscous hydrogel sheet of the present invention is preferably manufactured to a thickness of 0.05 to 0.3 cm, more preferably 0.1 to 0.2 μm. At this time, it is preferable that the coating is uniform in all areas. If the thickness of the viscous adhesive hydrogel sheet is less than 0.05 cm, it is difficult to handle due to the thin film. If the thickness exceeds 0.3 cm, adhesion to the curved skin is deteriorated.

Subsequently, the adhesive hydrogel sheet provided according to the present invention can be manufactured in a form capable of applying any specific part of the skin, and can be manufactured in any desired shape and size depending on the application site and application.

Generally, in the case of a skin patch with a hydrophilic polymer, sufficient crosslinking is not performed, and the physical properties of the gel are poor and sticky, so that it is difficult to form the gel directly without aging. Therefore, It is necessary to perform aging for about one day to two days. However, in the case where a hydrophilic polymer is contained together with the gelled polymer as in the present invention, a sticky hydrogel composition which can be formed immediately without such an aging step can be produced.

Further, according to the present invention, there is provided the adhesive hydrogel sheet produced by the above method.

Hereinafter, the present invention will be described more specifically by way of specific examples. The following examples are given for the purpose of helping to understand the present invention, but the scope of the present invention is not limited thereto.

Example  1 to 3

In the following Table 1, components 1, 2, 5 to 10 were mixed at a temperature of 75 캜, and components 3, 4, 11 to 18 were added to prepare a gel.

The gel was coated on a PET film support and molded into the desired shape without further aging.

NO Name Example 1 Example 2 Example 3 One Purified water 68.88 65.76 62.24 2 Carrageenan 0.5 1.0 2.0 3 glycerin 25 20 25 4 Sorbitol 0 5 0 5 Arbutin 2 2 5 6 Hydrolized Collagen 0.1 0.1 0.1 7 Marchia extract 0.1 0.1 0.1 8 Methylparaben 0.15 0 0.15 9 Propylparaben 0.05 0 0.05 10 1,2-hexanediol 0 2.5 0 11 Tataric acid 0.01 0.10 0.05 12 Disodium iodide 0 0.01 0.05 13 Polyvinylpyrrolidone 0 0.1 One 14 Sodium polyacrylate 3 3 2 15 Polyvinyl alcohol 0 0.1 2 16 Aluminum hydroxide 0.1 0.12 0.15 17 Spices 0.01 0.01 0.01 18 Polysorbate 60 0.1 0.1 0.1

* Unit: Weight%

Example  4 to 6

In the following Table 2, the components 1, 2, 5 to 10 were mixed at a temperature of 75 캜, and then the components 3, 4, 11 to 18 were added to prepare a gel.

The gel was coated on a PET film support and molded into the desired shape without further aging.

NO Name Example 4 Example 5 Example 6 One Purified water 56.02 55.35 47.49 2 Carrageenan 3.0 4.0 5.0 3 glycerin 20 30 20 4 Sorbitol 10 0 10 5 Arbutin 2 2 2 6 Hydrolized Collagen 0.1 0.1 0.1 7 Marchia extract 0.1 5 8.0 8 Methylparaben 0 0.15 0 9 Propylparaben 0 0.05 0 10 1,2-hexanediol 2.5 0 2.5 11 Tataric acid One 0.08 0.5 12 Disodium iodide 0.05 0.01 0.1 13 cellulose 0.5 0 0 14 gelatin 0.5 0 2 15 Sodium polyacrylate 4 3 2 16 Aluminum hydroxide 0.12 0.15 0.20 17 Spices 0.01 0.01 0.01 18 Polysorbate 60 0.1 0.1 0.1

* Unit: Weight%

Comparative Example  One

A pressure-sensitive adhesive composition was prepared in the same manner as in Example 1, except that the gelled polymer was not added. Specific compositions are shown in Table 3 below.

The prepared sticky composition was coated on a PET film support and then aged at a temperature of 50 캜 for 24 hours and then molded. As shown in FIG. 1, in the case of Comparative Example 1, it was difficult to mold immediately after coating and molding was impossible. It was confirmed that the molding was hardened to such an extent that molding could be carried out for at least 1-2 days, , It can be confirmed that coating is possible immediately after coating on the support.

NO Name Comparative Example 1 One Purified water 58.84 2 glycerin 30 3 Arbutin 2 4 Hydrolized Collagen 0.1 5 Marchia extract 0.1 6 Methylparaben 0.15 7 Propylparaben 0.05 8 1,2-hexanediol 0 9 Tataric acid 0.5 10 Disodium iodide 0.05 11 Sodium polyacrylate 3 12 Polyacrylic acid 5 13 Aluminum hydroxide 0.1 14 Spices 0.01 15 Polysorbate 60 0.1

* Unit: Weight%

Comparative Example  2

The viscous hydrogel prepared according to Example 1 was coated on a PET film and aged at a temperature of 50 캜 for 24 hours.

Test Example  1: Evaluation of stickiness

The sticky hydrogel sheets prepared according to Examples 1 and 2 and the sheet of Comparative Example 1 were attached to the upper arm portions of 20 subjects of healthy male and female subjects for 10 hours each, and sensory examination was performed.

The adhesion index is as shown in Table 4 below.

Degree of peeling Peel off more than 1/2 1/3 exfoliation 1/4 exfoliation Peel off No peeling Evaluation value One 2 3 4 5

The degree of exfoliation was measured, and the degree of exfoliation was calculated by dividing the number of subjects by the number of subjects. The following Table 5 shows the average of the degree of peeling calculated by the above evaluation method.

Attachment Index Example 1 4.5 Example 2 4.3 Comparative Example 1 4.1

As shown in Table 5, the pressure-sensitive adhesive sheets of Examples 1 and 2 of the present invention exhibited excellent adhesion as compared with the sheet of Comparative Example 1. [

Test Example  2: Hardness measurement

The hardness of the gel was measured using a Sun Rheometer Meter Compac-100 Ⅱ (Sun Scientific, Japan). The sample to be measured was cylindrical and had a width of 50 mm and a length of 50 mm.

In the hardness measurement, the adapter was measured with a diameter of 10 mm, a penetration distance of 15 mm and a maximum stress of 2 kg.

Immediately after gel formation After 24 hours of gel formation After 48 hours of gel formation Example 1 0.031 0.074 0.079 Comparative Example 1 0.032 0.029 0.024

* Unit: Hardness (N)

Claims (13)

A gelling polymer, a skin active ingredient, a polyhydric alcohol, a hydrophilic polymer, a cross-linking agent, a gelation rate regulator and a solvent,
Wherein the gelled polymer is at least one selected from the group consisting of galactomannan, glucomannan, guar gum, locust bean gum, pluronic, agar, carrageenan, and gellan.
The composition of claim 1, wherein the viscous hydrogel composition comprises 0.1 to 10% by weight of a gelled polymer, 0.1 to 15% by weight of a skin active ingredient, 5 to 35% by weight of a polyhydric alcohol, 0.5 to 10% by weight of a hydrophilic polymer, %, A gelling rate modifier of 0.01 to 5 wt%, and a solvent of 45 to 80 wt%.
delete The composition of claim 1, wherein the skin active ingredient is selected from the group consisting of arbutin, niacinamide, vitamin C, vitamin B5, vitamin E, retinol, coenzyme Q10, adenosine, elastin, collagen, hyaluronic acid, chitosan, By weight based on the total weight of the composition.
5. The method of claim 4, wherein the natural extract is selected from the group consisting of aloe, green tea, ginseng, red ginseng, vinegar, pine leaf, ginkgo leaf, propolis, mulberry leaf, silkworm, snail slime, kakaduplum, camucam, yashiyaki, squalane, , Blueberry, location hazel, acerola, chlorella, mangosteen, guava, mountain demand, carrots, caffeine, hammamelis, spirulina, salmon roe, gatti, giant kelp, packing, At least one member selected from the group consisting of raspberries, red raspberries, red peppers, edodes, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, Tacky hydrogel composition.
The adhesive hydrogel composition according to claim 1, wherein the polyhydric alcohol is at least one selected from the group consisting of glycerin, ethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, sorbitol, and xylitol.
The method of claim 1, wherein the hydrophilic polymer is selected from the group consisting of gelatin, polyacrylate or a salt thereof, polymethacrylic acid, carboxyvinyl polymer, polyvinyl alcohol, polyacrylamide, polyethylene oxide, polyethyleneimine, polyvinylpyrrolidone, methyl Cellulose, Cellulose. Carboxymethylcellulose, and hydroxyethylcellulose. ≪ RTI ID = 0.0 > 1. < / RTI >
The adhesive hydrogel composition according to claim 1, wherein the gelling rate modifier is at least one selected from the group consisting of EDTA, acetic acid, lactic acid, oxalic acid, citric acid, tartaric acid, EDTA-2 sodium, calcium citrate and sodium citrate.
Mixing the gelled polymer, the skin active ingredient, and the solvent at a temperature of 60 to 80 캜;
Preparing a gel by adding a hydrophilic polymer, a polyhydric alcohol, a gelation rate regulator, and a crosslinking agent; And
Coating the gel on a support
Wherein the adhesive layer is formed of a thermoplastic resin.
10. The method of claim 9, wherein the viscous hydrogel sheet comprises 0.1 to 10% by weight of a gelled polymer, 0.1 to 15% by weight of a skin active ingredient, 5 to 35% by weight of a polyhydric alcohol, 0.5 to 10% by weight of a hydrophilic polymer, 0.01 to 5% by weight of a gelling rate modifier, and 45 to 80% by weight of a solvent.
The process for producing a sticky hydrogel sheet according to claim 9, wherein the sheet is produced with a thickness of 0.5 to 30 mm.
10. The method of claim 9, wherein the support is selected from the group consisting of paper, nonwoven fabric, polyethylene terephthalate or polybutylene terephthalate, polyethylene naphthalate, polyethylene, polypropylene, polybutadiene, ethylene vinyl acetate copolymer, polyvinyl chloride film By weight based on the total weight of the hydrogel sheet.
A sticky hydrogel sheet produced by the production method according to any one of claims 9 to 12.

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