KR101589673B1 - infectious disease diagnosis method and apparatus by image of reagent kit - Google Patents

Abstract

In a method for diagnosing an infectious disease through an image of a reagent kit according to the present invention, the reagent kit comprises a negative reagent that provides a reference color for negative determination, a positive reagent that provides a reference color for positive determination, The method comprising: obtaining a reagent kit image by photographing the negative reagent, the positive reagent, and the reagent into which the specimen is injected, together with the reaction reagent; Detecting a negative reagent region corresponding to the negative reagent, a positive reagent region corresponding to the positive reagent, and a reaction reagent region corresponding to the reaction reagent in the image of the reagent kit; Comparing the hue of the reaction reagent region with the hue of the negative reagent region and the positive reagent region to determine negative / positive for the reaction reagent; And determining the voice / affinity for the infectious disease according to the result of the voice / affirmative determination.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method and an apparatus for diagnosing an infectious disease through an image of a reagent kit,

The present invention relates to a method and apparatus for diagnosing an infectious disease, and more particularly, to a method and an apparatus for diagnosing an infectious disease by analyzing an image of a diagnostic reagent kit.

It is very important to accurately and quickly diagnose the infectious disease and identify the infectious pathway early and to prevent the spread of the infectious disease since the medical, social, and economic damage increases greatly as the infection spreads after the first onset.

For example, influenza, which is a typical infectious disease, is an infectious disease caused by influenza virus. In general, when infected with a human, it causes general discomfort such as chills, fever, sore throat, muscular pain, headache, cough and helplessness. It may lead to complications such as Inlay syndrome and death in elderly people. Infections are spread by the substances that come into the air through coughing or sneezing of the infected person, and it can be spread by the excretion of birds, saliva, runny nose, feces and blood. There are various infectious diseases such as SARS, MERS, and cholera as well as influenza, and there are bacteria or viruses due to each infectious disease. However, viruses are only 20-400 nm in size and can not be distinguished from the naked eye. They can be observed by using an electron microscope or the like.

Diagnostic reagent kits are being used to quickly and accurately diagnose these infectious diseases. Normally, a physician or a diagnostician judges the positive / negative for the infectious disease by observing the color change of the diagnostic reagent with the naked eye. However, such a method depends entirely on the ability or skill of a diagnostician, so there is a limit to accuracy and an error may occur depending on the diagnostic environment such as surrounding illumination. In addition, a large number of diagnostic reagents are required or a large amount of time is required to read a large quantity of diagnostic reagent kits.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made in view of the above problems, and an object of the present invention is to provide an infection diagnosis method and apparatus capable of diagnosing an infectious disease by analyzing images taken by a diagnostic reagent kit.

The problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems that are not mentioned can be clearly understood by those skilled in the art from the following description.

In accordance with the present invention, there is provided a method for diagnosing an infectious disease through an image of a reagent kit, comprising the steps of: preparing a negative reagent for providing a reference color for negative determination, And at least one reaction reagent into which the sample is to be introduced, wherein the infection diagnosis method comprises the steps of: (a) photographing the reaction reagent into which the negative reagent, the positive reagent and the specimen are injected together to obtain a reagent kit image; (b) detecting a negative reagent region corresponding to the negative reagent, a positive reagent region corresponding to the positive reagent, and a reaction reagent region corresponding to the reagent in the image of the reagent kit; (c) comparing the hue of the reaction reagent region with the hue of the negative reagent region and the positive reagent region to determine negative / positive for the reaction reagent; And (d) determining the voice / affinity for the infectious disease according to the result of the voice / affirmative determination.

The method for diagnosing an infectious disease may further include converting an RGB value of each pixel of the reagent kit image into an HSV value.

The step (b) comprises: identifying pixels in the reagent kit image in which the HSV value of the pixel belongs to a predetermined range; And detecting, as the negative reagent region, the positive reagent region, and the reaction reagent region, regions having the size of the region including the identified pixels not smaller than a predetermined size.

In the step (c), the HSV value of the reaction reagent region may be compared with the HSV values of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent.

In the step (c), an average of the HSV values of the reaction reagent region may be compared with an average of the HSV values of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent.

Wherein the step (c) comprises: determining an audio reference color range including an average of the HSV values of the audio reagent area; Determining a positive reference color range comprising an average of the HSV values of the positive reagent region; And determining that the average of the HSV values in the reaction reagent region belongs to the negative reference color range and the negative determination if the average of the HSV values in the reaction reagent region belongs to the positive reference color range .

The step (c) may further include determining that the negative / positive determination is not possible if the average of the HSV values in the reaction reagent region does not fall within both of the negative reference hue range and the positive reference hue range.

According to an aspect of the present invention, there is provided an apparatus for diagnosing an infectious disease through an image of a reagent kit, the reagent kit comprising: a negative reagent for providing a reference color for negative determination; And at least one reaction reagent to which a specimen is to be injected, wherein the infection diagnosis apparatus comprises: an image acquiring unit for acquiring an image of a reagent kit by taking the negative reagent, the positive reagent, and the reagent into which the specimen is injected together; A reagent region detector for detecting a negative reagent region corresponding to the negative reagent, a positive reagent region corresponding to the positive reagent, and a reaction reagent region corresponding to the reagent in the image of the reagent kit; And comparing the hue of the reaction reagent region with the hue of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent, and determining the negative / positive of the infectious disease according to the negative / positive determination result And an infectious disease judging unit for judging the infectious disease.

The image obtaining unit may convert an RGB value of each pixel of the reagent kit image into an HSV value.

Wherein the reagent area detecting unit identifies pixels in which the HSV value of the pixel belongs to a predetermined range in the reagent kit image and sets the areas having the size of the area including the identified pixels not smaller than a predetermined size to the negative reagent area, And as the reaction reagent region.

The infection disease judgment unit may compare the HSV value of the reaction reagent region with the HSV value of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent.

The infection disease judgment unit may compare the average of the HSV values of the reaction reagent region with the average of the HSV values of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent.

Wherein the infection disease judgment section determines a negative reference color range including an average of the HSV values of the negative reagent region and a positive reference color range including an average of HSV values of the positive reagent region, A negative judgment is made when the average of the HSV values belongs to the negative reference color range and a positive judgment is made when the average of the HSV values of the reaction reagent zone belongs to the positive reference color range.

The infectious disease judging section can judge that the negative / positive judgment can not be made when the average of the HSV values in the reaction reagent region does not fall within both of the negative reference hue range and the positive reference hue range.

According to the present invention described above, the infectious disease can be diagnosed more accurately and quickly by effectively analyzing images taken by the diagnostic reagent kit, and it is possible to judge whether or not the infecting disease is infectious to a large quantity of diagnostic reagent kits Do.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the following description.

Figure 1 shows an example of a reagent kit used in an embodiment of the present invention.
2 shows a configuration of an apparatus for diagnosing an infectious disease according to an embodiment of the present invention.
3 shows a flowchart of a method for diagnosing an infectious disease according to an embodiment of the present invention.
Figure 4 shows an example of a photographed reagent kit image.
Figure 5 shows an example of a reagent kit image cropped from the reagent kit image of Figure 4;
6 shows an example of a process of identifying pixels whose HSV values belong to a predetermined color range in a reagent kit image.
Figure 7 shows an example of an algorithm for detecting reagent regions in a reagent kit image.
FIG. 8 is a flowchart illustrating a process of determining the voice / affinity of a reaction reagent according to an embodiment of the present invention.
FIG. 9 shows an example of a screen for outputting negative / positive determination results for each reaction reagent.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. In the following description and the accompanying drawings, substantially the same components are denoted by the same reference numerals, and redundant description will be omitted. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

In the following examples, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

In the following embodiments, terms such as inclusive or possessive are intended to mean that a feature, or element, described in the specification is present, and does not preclude the possibility that one or more other features or elements may be added.

If certain embodiments are otherwise feasible, the particular process sequence may be performed differently from the sequence described. For example, two processes that are described in succession may be performed substantially concurrently, and may be performed in the reverse order of the order described.

A method and apparatus for diagnosing an infectious disease according to an embodiment of the present invention diagnose an infectious disease by analyzing the obtained image of a reagent kit by photographing a reagent kit with a camera to obtain an image. The infectious disease diagnosis apparatus may be implemented through a portable terminal such as a smart phone or a tablet PC equipped with a camera, or a PC or a notebook without (or equipped with) a camera. The infection diagnosis method may be implemented through a mobile application installed in a portable terminal such as a smart phone or a tablet PC, or through a program installed in a PC or a notebook computer.

Figure 1 shows an example of a reagent kit used in an embodiment of the present invention.

Referring to FIG. 1, the reagent kit 10 is for diagnosing a specific infectious disease, and comprises a plurality of transparent tubes and reagents contained in each tube. The reagents include a negative reagent 11 that provides a reference color for negative determination, a positive reagent 12 that provides a reference color for positive determination, and one or more reagents to which a sample (e.g., needle, blood, etc.) (13). Each of the reaction reagents (13) is prepared so that the color changes in response to the input of a specimen containing a specific pathogen. For example, the sixth tube contains reagents that react with H3N2, a subtype of the influenza virus, and the eighth tube contains reagents that react with H1N1. The negative reagent (11) and the positive reagent (12) are formed so as to have a hue that serves as a reference for distinguishing whether the reaction of the reaction reagent (13) is negative or positive. The reagent kit 10 is provided with a criterion for determining whether the infectious disease is negative / positive based on the results of the negative / positive determination of the reaction reagents 13. For example, the criterion is that if the third to eighth reagents are all positive, the infectious disease is positive, and if any of the third to eighth reagents are negative, the infectious disease is judged to be negative.

Hereinafter, embodiments of the present invention will be described by taking an image of the reagent kit 10 of FIG. 1 as an example, but it goes without saying that the configuration of the reagent kit 10 may be changed according to the embodiment. For example, the positions of the negative reagent 11 and the positive reagent 12, the number of the reaction reagents 13, and the like may be changed.

2 shows a configuration of an apparatus for diagnosing an infectious disease according to an embodiment of the present invention.

2, the apparatus for diagnosing an infectious disease according to the present embodiment includes an image acquiring unit 100 for acquiring an image of a reagent kit by photographing a negative reagent 11, a positive reagent 12, and a reaction reagent 13 into which a specimen is injected, A reagent region detector 200 for detecting a negative reagent region corresponding to the negative reagent 11, a positive reagent region corresponding to the positive reagent 12, and a reaction reagent region corresponding to the reaction reagent 13 in the reagent kit image, , And a color of the reaction reagent region is compared with the negative reagent region and the positive reagent region to determine the negative / positive for the corresponding reagent (13) and determine the negative / positive for the infectious disease according to the determination result 300).

FIG. 3 is a flowchart of a method for diagnosing an infectious disease according to an embodiment of the present invention. Referring to FIG. 3, the operation of the infectious disease diagnostic apparatus of FIG. 1 will be described.

In step S310, the image acquiring unit 100 acquires a reagent kit image by taking together the negative reagent 11, the positive reagent 12, and the reaction reagent 13 into which the sample is injected. According to the embodiment, however, the image acquiring unit 100 may acquire the photographed reagent kit image through the network or from the memory. Typically, the reagent kit image obtained in step S310 is an RGB image.

Figure 4 shows an example of a photographed reagent kit image. As shown, when the reagent kit is photographed, the marker 500 can be placed and photographed in the vicinity of the reagent kit to facilitate recognition of the tube and the reagent portion. That is, since the position of the tube and reagent in the image is changed according to the photographing position and the distance, the tube and the reagent are disposed inside the marker 500, so that the reagent portion can be easily recognized from the photographed image.

In step S320, the image obtaining unit 100 recognizes the marker 500 in the photographed image, crops a portion corresponding to the reagent inside the marker 500, and adjusts the resolution and size of the cropped image . This process makes it possible to analyze the image under the same conditions. FIG. 5 shows an example of a reagent kit image cropped using the marker 500 from the reagent kit image of FIG.

In step S330, the image obtaining unit 100 converts the RGB values of each pixel of the reagent kit image obtained through step S320 into HSV values. The HSV value of each pixel is stored as an index for each pixel separately from the RGB image.

There are CIE model, RGB model, HSV model, YCrCb model, CMY model, and the like as a color model which expresses a color.

The RGB model expresses all colors by combining the three colors of red, green, and blue, which are the three primary colors of light, and expresses the colors as brightness values for the above three colors. In image processing, an RGB model typically represents a pixel using values of 0 to 255 for red, green, and blue, respectively. For example, pure red is represented by (255, 0, 0).

The HSV model is a color model most similar to human vision, and is a method of expressing color with three components: hue, saturation, and brightness. The hue represents a series of colors, the saturation represents the sharpness of the color, and the lightness represents the intensity. The HSV model has different range values according to the system of expressing information. In general, H, S, and V values are represented by values between 0 and 255 in the image processing. The H value represents the sequence and type of color, so the value represents the index, not the size. The S value indicates achromatic color at 0, and the sharpest color at 255. The smaller the V value, the darker the color, the brighter the larger the color.

The HSV model is intuitive in color representation, has the advantage of being able to accurately compare color similarities and to set boundary values for color comparisons. Therefore, in the embodiment of the present invention, the RGB values of each pixel of the reagent kit image are converted into the HSV values, and analysis is performed with the HSV values.

On the other hand, if the given illumination is too bright or dark when shooting the reagent kit, accurate diagnosis may not be made. Therefore, the reagent area detector 200 analyzes the illumination from the reagent kit image in step S340, and determines whether the predetermined illumination condition is satisfied in step S345. For example, the reagent area detector 200 calculates the illuminance value in the reagent kit image and determines whether the illuminance value falls within a predetermined range. If the illumination condition is not satisfied, the infectious disease diagnostic apparatus outputs in S347 that the infectious disease diagnosis can not be performed.

When the illumination condition is satisfied in step S345, the reagent area detecting unit 200 detects the negative reagent area corresponding to the negative reagent 11, the positive reagent area corresponding to the positive reagent 12, the reaction reagent 13 corresponding to the positive reagent 12, Of the reaction reagent.

In order to detect such reagent areas, pixels having HSV values of pixels in a reagent kit image are identified in a predetermined color range at step S350. Next, at step S360, The negative reagent region, the positive reagent region, and the reaction reagent region.

The HSV value used herein may be H value, H value and S value, or H value, S value and V value. The predetermined color range is preset as a range of colors that the negative reagent 11, the positive reagent 12, and the reaction reagent 13 can have so as to be distinguished from the surrounding color. The region where the pixels belonging to the color range are collected at a predetermined size or more can be regarded as the reagent region. Therefore, the regions having the size of the region including the identified pixels exceeding the predetermined size can be detected as the reagent region.

6 shows an example of a process of identifying pixels whose HSV values belong to a predetermined color range in a reagent kit image. For example, an initial value of '-1' is given to all pixels in the reagent kit image, and a '1' value is given to a pixel within the color range by checking whether the HSV value belongs to a predetermined color range per pixel, Quot; 0 "

Figure 7 shows an example of an algorithm for detecting reagent regions in a reagent kit image. 7, a pixel belonging to a color range (Bound _Low to Bound _Upper ) is _divided into regions (Contours _Masked ) including identified pixels (pixels assigned a value of '1') from the identified image information ), And detects a reagent region by searching for regions exceeding a predetermined size (Threshold Area _Contour ) among the extracted regions. Since the order of the negative reagent 11, the positive reagent 12 and the reaction reagent 13 in the given reagent kit 10 is predetermined, a negative reagent region, a positive reagent region, and a reaction reagent region are designated in each detected reagent region .

For example, in the case of the reagent kit image of FIG. 5, when eight reagent regions are found, a negative reagent region, a positive reagent region, and a reaction reagent region will be sequentially detected from the left.

Referring again to FIG. 3, in step S370, the infectious disease determination unit 300 compares the hue of each reaction reagent region with the hue of the negative reagent region and the positive reagent region to determine the negative / positive of the corresponding reaction reagent. Since the reagent kit image is an image of the negative reagent 11, the positive reagent 12 and the reaction reagent 13 taken together, the imaging conditions of these reagents are the same. According to the embodiment of the present invention, the colors of the reagent kits photographed in the same environment are compared, and accurate determination results can be obtained without being affected by the photographing environment.

In step S370, the infection suspect determining unit 300 compares the HSV value of the reaction reagent region with the HSV value of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent. At this time, the infectious disease judging unit 300 can compare the average of the HSV values of the reaction reagent region with the average of the HSV values of the negative reagent region and the positive reagent region to determine the negative / positive of the reaction reagent. The HSV value used herein may be H value, H value and S value, or H value, S value and V value.

FIG. 8 is a flowchart illustrating a process of determining the voice / affinity of a reaction reagent according to an embodiment of the present invention.

In step S810, the infection suspect determining unit 300 calculates the average HSV value (CutoffColor_nc_avg) of the voice reagent area.

In step S820, an audio reference color range including CutoffColor_nc_avg is determined. For example, a value smaller than CutoffColor_nc_avg may be determined as CutoffColor_nc_min, a value larger than CutoffColor_nc_avg by a predetermined value may be determined as CutoffColor_nc_max, and the audio reference color range may be determined as CutoffColor_nc_min to CutoffColor_nc_max.

In step S830, the infection suspect determining unit 300 calculates the average HSV value (CutoffColor_pc_avg) of the positive reagent region.

In step S840, a positive reference color range including CutoffColor_pc_avg is determined. For example, a value smaller than CutoffColor_pc_avg may be determined as CutoffColor_pc_min, a value larger than CutoffColor_pc_avg by a predetermined value may be determined as CutoffColor_pc_max, and a positive reference color range may be determined as CutoffColor_pc_min to CutoffColor_pc_max.

In step S850, the infection susceptibility determining unit 300 calculates the average HSV value (Color_i_avg) of the i th reaction reagent region. For a given reagent kit 10, i = 3 to 8.

If Color_i_avg belongs to the voice reference color range (CutoffColor_nc_min to CutoffColor_nc_max) in step S860, the i th reaction reagent is judged as negative in step S865.

If Color_i_avg does not belong to the voice reference color range (CutoffColor_nc_min to CutoffColor_nc_max) in step S860 and Color_i_avg belongs to the positive reference color range (CutoffColor_pc_min to CutoffColor_pc_max) in step S870, the i th reaction reagent is determined to be positive in step S875.

If the Color_i_avg does not belong to the positive reference color range (CutoffColor_pc_min to CutoffColor_pc_max) in step S870, it is determined in step S880 that the i th reaction reagent is negative / positive determination.

Referring again to FIG. 3, in step S380, the infection susceptibility determining unit 300 determines whether the negative / positive determination result of step S370 for each reaction reagent 13 and the negative / positive test for the infectious disease according to the acceptance criteria given to the reagent kit .

In step S390, the infection control unit 300 outputs the determination results of step S370 and step S380. If the negative / positive determination of some or all of the reaction reagents is not possible in step S370 and the negative / positive determination of the infectious disease is impossible in step S380, it indicates that the infectious disease determination is impossible.

FIG. 9 shows an example of a screen for outputting negative / positive determination results for each reaction reagent. Referring to FIG. 9, the color of each reaction reagent is shown and a negative / positive determination result is shown. In the illustrated example, it can be confirmed that the determination results are negative, positive, positive, negative, positive, and negative for the third to eighth reaction reagents, respectively. In the case where all of the reagents are positive, the infectious disease determination result is negative. In the example of FIG. 9, if the infection is positive, if any of the reagents is negative, the infection is determined as negative.

According to the present invention, it is possible to diagnose the infectious disease more accurately and promptly by efficiently diagnosing the infectious disease by using the color of the image taken by the diagnostic reagent kit, .

In addition, the color of each reagent region is compared with the image obtained by photographing the negative reagent, the positive reagent, and the reaction reagent together to determine the voice / positiveness, so that accurate judgment results can be obtained without being affected by the photographing environment.

Also, by comparing colors using the HSV values in the reagent kit area, it is possible to effectively set the boundary value for color comparison and to more accurately determine the similarity of reagent colors.

In addition, even if the diagnostic reagent kit is changed, there is an advantage that it is possible to support various kinds of diagnostic reagent kits because only a few settings (the number of reagents, order determination criteria, etc.) given to the diagnostic reagent kit can be changed.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art . Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

Embodiments may be represented by functional block configurations and various processing steps. These functional blocks may be implemented in a wide variety of hardware and / or software configurations that perform particular functions. For example, embodiments may include integrated circuit components such as memory, processing, logic, look-up tables, etc., that may perform various functions by control of one or more microprocessors or other control devices Can be employed.

Similar to the components of the present invention may be implemented with software programming or software components, embodiments may include various algorithms implemented in a combination of data structures, processes, routines, or other programming constructs, such as C, C ++ , Java (Java), assembler, and the like. Functional aspects may be implemented with algorithms running on one or more processors. The embodiments may also employ conventional techniques for electronic configuration, signal processing, and / or data processing. Terms such as "mechanism", "element", "means", "configuration" may be used broadly and are not limited to mechanical and physical configurations. The term may include the meaning of a series of routines of software in conjunction with a processor or the like.

The specific implementations described in the embodiments are, by way of example, not intended to limit the scope of the embodiments in any way. For brevity of description, descriptions of conventional electronic configurations, control systems, software, and other functional aspects of such systems may be omitted. Also, the connections or connecting members of the lines between the components shown in the figures are illustrative of functional connections and / or physical or circuit connections, which may be replaced or additionally provided by a variety of functional connections, physical Connection, or circuit connections. Also, unless explicitly mentioned, such as "essential "," importantly ", etc., it may not be a necessary component for application of the present invention.

The use of the terms "above" and similar indication words in the description of the embodiments (in particular in the claims) may refer to both singular and plural. In addition, in the embodiment, when a range is described, it includes the invention to which the individual values belonging to the above range are applied (if there is no description to the contrary), the individual values constituting the above range are described in the detailed description . Finally, the steps may be performed in an appropriate order, unless explicitly stated or contrary to the description of the steps constituting the method according to the embodiment. The embodiments are not necessarily limited to the description order of the steps. The use of all examples or exemplary terms (e.g., etc.) in the examples is for the purpose of describing the embodiments in detail and is not intended to be limited by the scope of the claims, It is not. It will also be appreciated by those skilled in the art that various modifications, combinations, and alterations may be made depending on design criteria and factors within the scope of the appended claims or equivalents thereof.

Claims (14)

A method for diagnosing an infectious disease through an image of a reagent kit,
The reagent kit comprising a negative reagent providing a reference color for negative determination, a positive reagent providing a reference color for positive determination, and at least one reagent to which the sample is to be introduced,
(a) photographing the reaction reagent into which the negative reagent, the positive reagent, and the sample are injected together to obtain a reagent kit image, and converting an RGB value of each pixel of the reagent kit image into an HSV value;
(b) detecting a negative reagent region corresponding to the negative reagent, a positive reagent region corresponding to the positive reagent, and a reaction reagent region corresponding to the reagent in the image of the reagent kit;
(c) comparing the average of the HSV values of the reaction reagent region with the average of the HSV values of the negative reagent region and the positive reagent region to determine the negative / positive for the corresponding reagent; And
(d) judging whether or not the infection / disease is positive / negative based on the result of the negative / positive judgment. delete The method according to claim 1,
The step (b)
Identifying pixels in the reagent kit image in which the HSV value of the pixel falls within a predetermined range; And
And detecting regions having a size of the region including the identified pixels equal to or larger than a predetermined size as the negative reagent region, the positive reagent region, and the reaction reagent region. delete delete The method according to claim 1,
The step (c)
Determining an audio reference color range comprising an average of HSV values of the audio reagent region;
Determining a positive reference color range comprising an average of the HSV values of the positive reagent region; And
Determining that the average of the HSV values in the reaction reagent region belongs to the negative reference color range, and determining that the average value of the HSV values in the reaction reagent region is positive if the average of the HSV values in the reaction reagent region belongs to the positive reference color range Lt; / RTI > The method according to claim 6,
Wherein the step (c) further comprises determining that the negative / positive determination is not possible if the average of the HSV values in the reaction reagent region does not fall within both the negative reference hue range and the positive reference hue range Way. As an apparatus for diagnosing an infectious disease through an image of a reagent kit,
The reagent kit comprising a negative reagent providing a reference color for negative determination, a positive reagent providing a reference color for positive determination, and at least one reagent to which the sample is to be introduced,
An image acquiring unit for acquiring an image of a reagent kit by photographing the reaction reagent into which the negative reagent, the positive reagent and the sample are injected together, and converting an RGB value of each pixel of the reagent kit image into an HSV value;
A reagent region detector for detecting a negative reagent region corresponding to the negative reagent, a positive reagent region corresponding to the positive reagent, and a reaction reagent region corresponding to the reagent in the image of the reagent kit; And
Comparing the average of the HSV values of the reaction reagent region with the average of HSV values of the negative reagent region and the positive reagent region to determine the negative / positive for the corresponding reagent, and determining the negative / And an infectious disease judging section for judging the voice / positive. delete 9. The method of claim 8,
Wherein the reagent area detecting unit identifies pixels in which the HSV value of the pixel belongs to a predetermined range in the reagent kit image and sets the areas having the size of the area including the identified pixels not smaller than a predetermined size to the negative reagent area, And as the reaction reagent region. delete delete 9. The method of claim 8,
Wherein the infection disease judgment section determines a negative reference color range including an average of the HSV values of the negative reagent region and a positive reference color range including an average of HSV values of the positive reagent region, Judges negative when the average of the HSV values belongs to the voice reference hue range and judges it positive if the average of the HSV values of the reaction reagent region belongs to the positive reference hue range. 14. The method of claim 13,
Wherein the infectious disease judging unit judges that the negative / positive judgment is not possible if the average of the HSV values in the reaction reagent region does not fall within both of the negative reference hue range and the positive reference hue range.

Images