KR101762902B1 - Soluble type fibrous sheet for skin-contacting with optimized dispersibility of skin and usage using the same - Google Patents

Abstract

The present invention relates to a skin-contacting fibrous sheet of a dissolving formulation having excellent skin dispersibility and a product using the same.
The present invention provides a skin-contacting fibrous sheet in which a carboxymethylcellulose woven fabric or a nonwoven fabric is adjusted to a substitution degree of 0.4 or more to be dispersed and absorbed on the skin by physical dispersing force upon contact with water, A cosmetic sheet containing a high content of a cosmetic active ingredient, a water-soluble drug or a natural moisturizing ingredient, a drug delivery patch or a moisturizing sheet for treating atopy can be provided. Thus, by providing the product in the form of a dry sheet containing a skin-soluble component, it is easy to maintain the stability of the skin-soluble component in the formulation, so that it can be mounted in a high content and can be provided in a portable size, It is possible to provide a product of a novel formulation which can increase the yield.

Description

TECHNICAL FIELD [0001] The present invention relates to a skin-contacting fibrous sheet having excellent skin dispersibility and a skin-contacting fibrous sheet using the same and a product using the same. [0002]

The present invention relates to a skin-contacting fiber sheet having excellent skin-dispersing ability, and to a product of a dissolving formulation using the same. More specifically, the present invention relates to a skin- The present invention provides a skin sheet for skin contact, which is dispersed and absorbed by a skin, comprising a cosmetic sheet containing a cosmetic active ingredient, a water-soluble drug or a natural moisturizing ingredient in a high content, Or a moisturizing sheet for the treatment of atopic diseases, thereby improving the skin transmission and absorption of skin oil-soluble components in contact with water due to the gelation property of natural cellulose, and a fiber sheet product of a dissolving formulation using the same.

Natural cellulose is the most abundant biomass on the planet and has been provided as a functional, low-cost recycled material for mankind for thousands of years, corresponding to an indefinite resource that repeats the cycle of generation, degradation, utilization, and production by the laws of nature. Such cellulose has been actively developed to utilize the cellulose component of the plant as a source of energy, food, etc. Recently, the need for environmentally friendly polymer materials has increased, and cellulose has been used for various functional polymer materials and industrial fields Polymeric resources.

In particular, since oxidized cellulose obtained by oxidizing such cellulose has a property of absorbing moisture while being gelled by moisture or body fluids, it is preferably used for medical applications such as wound dressings, sanitary napkins such as sanitary napkins and diapers, Packs and other cosmetic fields.

Carboxymethyl cellulose (CMC), which is oxidized and treated with the oxidized cellulose, is a cellulose derivative that has been proved as safety and efficacy. It is easily licensed, can be decomposed spontaneously, and can be used as a raw material harmless to human body .

More specifically, carboxymethyl cellulose (CMC) is a substance obtained by reacting wood-based cellulose with NaOH alkali treatment and MCA (Mono Chloroacetic Acid), and is already widely used as a viscosity modifier and additive in the food industry.

Most of the carboxymethyl cellulose (CMC) obtained through the above process is required to be in the form of a powder, but recently it has been required to provide fibrous carboxymethylcellulose such as fiber, woven fabric and nonwoven fabric instead of a powder form, have.

However, although the production method of carboxymethylcellulose fibrils is still being produced on a laboratory scale, the necessity of mass production of carboxymethylcellulose fibrils is expected to increase day by day due to an increase in demand due to expansion of use.

Korean Patent No. 1437082 discloses a composition in which carboxymethyl cellulose (CMC) fiber in which gelation occurs upon contact with water or body fluids and non-carboxymethyl cellulose (NON-CMC) fiber in which gelation does not occur is mixed with carboxymethyl cellulose (CMC) fibers are contacted with water or body fluids in the hybrid nonwoven fabric, and are thus effective for therapeutic purposes for medical or cosmetic purposes, and the non-carboxymethylcellulose (NON -CMC) fiber serves as a support, the strength is improved when the product is used, and since it is easy to remove after use, it is useful as a medical nonwoven fabric or a mask pack using the same.

Also, in the case of a cosmetic formulation in which a fiber and a cosmetic are combined, a method is employed in which a microcapsule having a polymerized structure containing a functional effective ingredient of a cosmetic is uniformly attached to the fibers so that the functional ingredient of the cosmetic is gradually released to the skin have. Such a method is applied not only to cosmetics including mask packs but also to functional apparel.

However, among the functional ingredients of cosmetics, retinol, ascorbic acid, and kocic acid, which are effective for moisturizing and elasticity, are excellent in efficacy, but due to instability of the functional active ingredient itself and discoloration and deterioration of the formulation containing the same, And it has been pointed out that the amount of skin absorption is small as the functional effective ingredient remains in the formulation.

Accordingly, the present inventors have made efforts to improve the conventional problems, and as a result, it has been found that a skin sheet for skin contact with melted form of carboxymethyl cellulose woven fabric or nonwoven fabric is provided through a technique capable of controlling gelation of a natural cellulose derivative, It is possible to mount a high content and it is possible to disperse and absorb on the skin due to physical dispersing ability in contact with water, so that it is possible to increase the amount of skin transfer and absorption of the skin oil-soluble ingredient By providing a novel form of portable size, the present invention has been completed

An object of the present invention is to provide a skin sheet for skin contact, which is capable of dispersing and absorbing the skin to a physical dispersing force upon moisture contact by controlling the degree of substitution so that the carboxymethylcellulose woven fabric or nonwoven fabric is dispersed and absorbed on the skin.

Another object of the present invention is to provide a cosmetic sheet of a dissolving formulation containing a cosmetic active ingredient in the skin-contacting fiber sheet of the dissolving formulation.

Yet another object of the present invention is to provide a drug delivery patch of a soluble formulation containing a water-soluble drug component in the skin-contacting fiber sheet of the above-mentioned dissolving formulation.

Still another object of the present invention is to provide a moisturizing sheet of a melted formulation for treatment of atopy, which contains a natural moisturizing ingredient in the skin-contacting fiber sheet of the above-mentioned melted formulation.

To achieve the above object, the present invention provides a skin-contacting fibrous sheet comprising a carboxymethylcellulose woven or nonwoven fabric having a degree of substitution of 0.4 or more, which is dispersed and absorbed on the skin by a physical dispersing force upon contact with water.

The carboxymethylcellulose woven or nonwoven fabric having a substitution degree of 0.4 or more according to the present invention is obtained from natural cellulose having a low molecular weight of 200 to 500 repeating units and a low weight of 30 to 40 g / m 2.

At this time, the degree of substitution of the carboxymethylcellulose woven fabric or the nonwoven fabric is 0.8 or more.

Also, the carboxymethylcellulose woven or nonwoven fabric has a size of 1 x 1 cm to 5 x 5 cm in width and length, and is capable of being dispersed and absorbed on the skin by physical dispersing force upon moisture contact.

Accordingly, the present invention provides a skin-contacting fiber sheet comprising a melted form of a carboxymethyl cellulose woven fabric or a non-woven fabric, wherein the skin-contactable fiber sheet has a cosmetic activity which realizes any skin improving function selected from the group consisting of moisturizing, The present invention provides a cosmetic sheet of a dissolving formulation containing a component.

More preferably, the present invention provides a cosmetic sheet of a dissolving formulation, which is applied to a portable lotion or mask pack containing a cosmetic active ingredient in the skin-contacting fiber sheet of the above-mentioned dissolving formulation.

In addition, the present invention provides a dissolution-type drug delivery patch containing a water-soluble drug component in a skin-contacting fiber sheet of melted form comprising carboxymethylcellulose woven fabric or nonwoven fabric.

Further, the present invention provides a moisturizing sheet for melanin for the treatment of atopy, which contains 50 to 80% by weight of a natural moisturizing ingredient in a skin-contacting fiber sheet of melted form of carboxymethylcellulose woven fabric or nonwoven fabric.

The present invention relates to a skin-contactable fiber sheet in which a carboxymethylcellulose woven fabric or a nonwoven fabric having a degree of substitution of 0.4 or more melts and is absorbed and dispersed on the skin by the physical dispersing force upon moisture contact, to provide.

The present invention provides a product in the form of a dry sheet containing a skin oil-soluble component in a skin-contacting fiber sheet of a melted form of a carboxymethylcellulose woven fabric or a nonwoven fabric, And it is possible to solve the problem of discoloration and spoilage in the formulation due to instability of the conventional skin oil-soluble component.

Furthermore, the present invention can provide a novel formulation of a product capable of increasing the amount of skin-transferable and absorbable components of the skin-soluble component even at a portable size.

FIG. 1 is a photograph of a skin-contacting fibrous sheet of a dissolving formulation according to the present invention in a state of being absorbed and gelled upon moisture contact,
FIG. 2 is a photograph sequentially showing a process of absorbing skin by a physical dispersing force when a cosmetic sheet of a dissolving formulation of the present invention is in contact with water,
Fig. 3 shows the moisturizing effect of the melted cosmetic sheet of the present invention before and after four weeks,
Fig. 4 shows the whitening effect before and after the melted cosmetic sheet of the present invention for 4 weeks,
Fig. 5 shows the result of UV spot measurement after UV irradiation before and after four weeks of the cosmetic sheet of the dissolving formulation of the present invention,
Fig. 6 shows the result of measurement of the brown spot after UV irradiation of the cosmetic sheet of the present invention for 4 weeks.

Hereinafter, the present invention will be described in detail.

Disclosed is a skin sheet for skin contact, which comprises a carboxymethylcellulose woven or nonwoven fabric having a substitution degree of 0.4 or more, wherein the natural cellulose end is substituted with a carboxyl group, and is dispersed and absorbed by the skin by the physical dispersing force upon moisture contact.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a photograph of a skin-contacting fibrous sheet of a dissolving formulation according to the present invention taken in a state of being absorbed and gelled upon moisture contact;

At this time, the melted form skin sheet for skin contact according to the present invention provides a novel formulation that maximizes the gelation property of natural cellulose by controlling the degree of substitution of the natural cellulose derivative.

The carboxymethylcellulose woven or nonwoven fabric of which the substitution degree is controlled according to the present invention is obtained from natural cellulose having a low molecular weight having 200 to 500 repeating units, preferably 200 to 300 repeating units.

If the repeating unit is less than 200, the sheet form can not be maintained due to the decrease in strength of the carboxymethylcellulose woven fabric or nonwoven fabric by alkali. When the number of repeating units exceeds 500, the dissociation of hydroxyl group by alkali is weakened and the degree of substitution is low.

The carboxymethylcellulose woven fabric or nonwoven fabric of the present invention is obtained from natural cellulose having a low weight of 30 to 40 g / m 2. If the weight range is out of the above range, gelation is possible upon moisture contact, And the sheet form is observed with the naked eye, which is not preferable for the formulation of the present invention.

The degree of substitution is controlled by immersing the cellulosic woven fabric or the nonwoven fabric in an alkali solution, padding it, aging at 20 to 50 DEG C for 30 to 60 minutes, and aging at 50 to 80 DEG C in the reaction solution comprising the carboxymethylation solvent after aging at 30 to 90 Min to obtain a carboxymethylcellulose woven or nonwoven fabric having a substitution degree of 0.4 or more.

When the concentration of the alkali solution (NaOH) is less than 15%, the required degree of substitution of carboxymethyl cellulose can not be obtained. When the concentration of the alkali metal solution (NaOH) is more than 40%, the acid (MCA) and the alkali NaOH), and the substitution degree of carboxymethyl cellulose is too high to be suitable for use in the product.

Also, when padding with 15 to 40% NaOH, the padding rate is preferably 300 to 400%, and the loss of the drug can be minimized because only the amount of cellulose can be retained. At this time, if the padding rate is less than 300%, the degree of substitution of hydrophilic carboxyl groups is low due to insufficient hydrophobic bond dissociation of cellulose molecules due to alkali, and if it exceeds 400%, the nonwoven fabric is damaged.

In order to dissociate the hydrogen bonds of the cellulose molecules after the padding, aging is carried out at 20 to 50 DEG C for 30 to 60 minutes. When the aging temperature is lower than 20 캜, the reaction is insufficient. When the aging temperature is higher than 50 캜, the reaction proceeds rapidly in the production of carboxymethyl cellulose, There is a problem that one carboxymethyl cellulose can not be obtained.

After the aging, a reaction solution obtained by dissolving a certain amount of a carboxymethylation solution (hereinafter referred to as MCA) in isopropyl alcohol is subjected to a substitution reaction at a temperature of 50 to 80 ° C for 30 to 90 minutes, Of carboxymethylcellulose woven or nonwoven fabric can be obtained.

After completion of the reaction, the reaction mixture is washed twice or three times with a washing solution containing isopropyl alcohol and water to remove unreacted substances of the natural cellulose derivative. At this time, After completion, the process of squeezing using an automatic mangle and drying continuously at a temperature of 120 ° C may be performed.

From the above, the degree of substitution of the obtained carboxymethylcellulose woven fabric or nonwoven fabric of the present invention is controlled to be 0.4 or more, more preferably 8.0 or more, and it is more effective in absorbing the skin due to excellent gelation by water, The present invention provides a skin sheet for contact with skin of a carboxymethylcellulose woven or nonwoven fabric which is finely dispersed and dissolved in the skin by physical dispersing force upon contact with water.

More specifically, the melting-type fiber sheet for skin contact of the present invention is capable of securing stability and natural decomposition to the skin due to the use of environmental and human-friendly cellulosic materials. In the above, "melting formulation" Means that the carboxymethylcellulose woven fabric or nonwoven fabric is finely dispersed in a state in which the naked eye is not visible by physical dispersing force, and it can be easily removed by washing with running water after use.

In addition, the skin-contacting fibrous sheet of the melted formulation of carboxymethylcellulose woven fabric or nonwoven fabric of the present invention is provided in a size of 1 x 1 cm to 5 x 5 cm in width and can be applied to a portable product.

Accordingly, the present invention can provide a product group of a formulation containing melanin content containing a skin-soluble ingredient in a skin-contacting fibrous sheet of melted form of carboxymethylcellulose woven fabric or nonwoven fabric.

At this time, the skin oil-soluble component is impregnated with the carboxymethylcellulose woven or non-woven fabric into the solution containing the oil-soluble component by a pad-dry method, and then dried to produce a product, which contains a high content of skin- So that it is easy to maintain the stability of the skin oil-soluble ingredient in the formulation. Accordingly, it is possible to solve the problem of discoloration and discoloration of the formulation due to the instability of the conventional skin oil-soluble component.

As a preferable example of the skin oil-soluble component in the embodiment of the present invention, the active ingredient of the cosmetic preparation is specifically described. However, the skin-contactable fiber sheet of melted formulation comprising the above-mentioned carboxymethyl cellulose woven fabric or non- The present invention is not limited to this.

As a preferred embodiment of the skin oil-soluble component, the present invention relates to a skin-contacting fibrous sheet of a melted formulation comprising the above-mentioned carboxymethylcellulose woven fabric or nonwoven fabric, and a method of moisturizing, A cosmetic composition containing the active ingredient of the cosmetic composition for realizing the skin improving function of the skin.

FIG. 2 is a photograph sequentially showing a process of skin absorption of a cosmetic sheet of a melted formulation according to the present invention by a physical dispersing force when the skin is in contact with water, wherein a cosmetic sheet having a size of 1 × 1 cm in width × 1 cm is placed on the back of the hand, Emulsion state. Then, when the cosmetic is spread on the back of the user's hand or face as if using a cosmetic product, the active ingredient of the cosmetic is absorbed into the skin, and the carboxymethyl cellulose woven fabric or the nonwoven fabric finely dispersed in the skin to the physical dispersing ability can be washed away with water.

At this time, the cosmetic sheet containing the active ingredient for cosmetics in the skin-contacting fibrous sheet of the present invention is provided in a size of 1 x 1 cm to 5 x 5 cm in width and is thus useful as a portable compact cosmetic, .

In addition, the cosmetic sheet containing the active ingredient for cosmetics in the skin-contacting fibrous sheet of the dissolving formulation of the present invention may be provided in the form of a portable size sheet having a width of 1 x 1 cm to 5 x 5 cm, It is useful as a mask pack because it can stabilize and increase the amount of skin transfer and absorption of the active ingredient of the cosmetic during moisture contact.

Clinical results of the cosmetic sheet is a cosmetic active ingredient contained in the fiber sheet for contact with skin of a melting formulations as given in the embodiment of the present invention is increased after four weeks using the cosmetic sheet (D28) skin moisture content (au) is and [3] , A good whitening effect [ Fig. 4 ], a decrease in the number of counts and scores of UV spots and brown spots after irradiation with ultraviolet rays ( Figs. 5 and 6 ) Effective skin delivery of the active ingredients of the cosmetic composition contained in the present invention can be confirmed.

Further, the present invention can provide, as a skin oil-soluble component, each product use containing a water-soluble drug ingredient or a natural moisturizing ingredient.

More specifically, the present invention provides a drug delivery patch of a soluble formulation containing a water-soluble drug component in a skin-contacting fiber sheet of melted form comprising carboxymethylcellulose woven fabric or nonwoven fabric.

The present invention also provides a moisturizing sheet for melanin for the treatment of atopy, which contains 50 to 80% by weight of a natural moisturizing ingredient in a skin-contacting fiber sheet of melted form of carboxymethylcellulose woven fabric or nonwoven fabric.

Hereinafter, the present invention will be described in more detail with reference to Examples.

The present invention is intended to more specifically illustrate the present invention, and the scope of the present invention is not limited to these embodiments.

< Example  1> Carboxymethylcellulose ( CMC Manufacture of nonwovens

A cellulose nonwoven fabric having a low molecular weight and a low weight of 30 g / m &lt; 2 &gt; satisfying 200 to 300 repeating units in which the hydroxy group at the terminal of cellulose was substituted with a hydrophilic carboxyl group was prepared in the form of rolls, And the pickup ratio was 300 to 400%. Then, it was sealed at room temperature and 50 DEG C for 30 minutes to dissociate the hydrogen bonds of the cellulose molecules and aged. Subsequently, a reaction solution in which monochloroacetic acid was dissolved in a sample and isopropyl alcohol in a reactor was subjected to a substitution reaction at a temperature of 50 ° C. for 90 minutes under a liquid ratio of 1:20 to prepare a carboxymethyl cellulose (CMC) nonwoven fabric .

< Example  2> Cosmetics  Sheet manufacture

A colorless and odorless eco-friendly moisturizer made by 100% natural glycol and vitamin C effective for skin whitening were mixed and dissolved in purified water, and 2 ~ 10g of antimicrobial extract powder having a skin soothing effect and minimizing skin irritation was dissolved in 20 ml of purified water And mixed for 30 to 60 to prepare a solution containing the cosmetic active ingredient.

A carboxymethylcellulose nonwoven fabric having a degree of substitution of 0.891 prepared in Example 1 was immersed in a solution containing the cosmetic active ingredient and then padded to prepare a cosmetic sheet having a size of 1 × 1 cm and having a pickup ratio of 70 to 100% . At this time, the content of the moisturizing agent and the vitamin C can be controlled by the pick-up rate.

< Experimental Example  1> Measurement of degree of substitution

The substitution degree of the carboxymethylcellulose (CMC) nonwoven fabric prepared in Example 1 was measured in accordance with ASTM D 1439-03 by changing the melting fiber form into an acid form and titrating the result.

Step 1: Acid type substitution

A sample of the melt-formable fiber was cut into 10 x 10 mm &lt; 2 &gt;, and 4 g of a fiber-forming sample to be melted in a 300 ml beaker was added.

The sample was immersed in 150 ml of 95% ethanol, and 5 ml of HNO ₃ was added to the beaker. After stirring for 2 minutes, the beaker was immersed in a heated water bath and the temperature was set to 100. At this time, the beaker was blocked with a silver foil so that the ethanol did not evaporate, and when the solvent in the beaker was boiled, it was kept for 10 minutes. Thereafter, the beaker was taken out from the water bath and stirred without temperature for 15 minutes.

150 ml of 95% ethanol was added to a separate beaker and washed with stirring for 10 minutes and repeated three times. A sample was placed in a Buchner funnel, and 200 ml of 80% ethanol was added thereto, followed by filtration under reduced pressure to remove the filtrate. This process was repeated three times. The washed sample was slightly removed and the presence of N ion was confirmed with a diphenylamine indicator. When the residual N ion was present, the sample was judged to be a dark blue color and no color. At this time, if dark blue color appeared, the washing process of 150 ml of 95% ethanol was repeated. If no residual ions were left, the sample was placed in a beaker, dried in a hood to allow alcohol to flow off, and then dried in a 105 oven for 3 hours to obtain acid-CMC.

Step 2: Titration

1 g of the fiber-modified sample in acid form dissolved in 300 ml beaker, 100 ml of distilled water and 2 ml of phenolphthalein solution were added and 50 ml of 0.1 N NaOH solution was added while stirring. The temperature was maintained at 100 for 20 minutes with a digital heating magnetic stirrer and the heating was stopped and titrated with 0.1 N HCl solution while stirring continuously. The titration was terminated when a clear color was observed in sword-red color.

Step 3: Calculation of degree of substitution (DS)

The degree of substitution (DS) was calculated according to the following formula (1) according to ASTM D 1439-03.

Equation 1

DS = 0.162 x A / (1 - 0.058 x A)

In the above, A is the sample weight (1 g) of the acid-fiber formulation used: 0.1 N × (the amount of NaOH added - the amount of HCl added).

The above degree of substitution degree measurement is shown in Table 1 below.

< Experimental Example  2> Human Clinical Experiment

1. Experimental conditions and methods

The cosmetic sheet having a size of 1 × 1 cm prepared in Example 2 was stored in a brown container in an airtight container for prevention of oxidation and was used under the conditions described in Table 2 below . After spreading the sheet on the top and dissolving it in water, it was applied to the face as if it was cosmetically applied. After 30 minutes, it was washed with water for 4 weeks. FIG. 2 is a photograph sequentially showing a process of absorbing skin by a physical dispersing force when a cosmetic sheet of a dissolving formulation of the present invention is in contact with water.

2. Evaluation of moisturizing effect

As a result of the above clinical tests, the moisturizing effect of before and after (D0, D28) the cosmetic sheet of the melted formulation for 4 weeks is shown in the following Table 3 , and the skin moisture amount measurement using the measuring device (Corneometer CM825) After 4 weeks (D28), skin moisture (au) was significantly increased.

Fig. 3 quantitatively shows the moisturizing effect before and after the melted formulation cosmetic sheet of the present invention for 4 weeks.

3. Evaluation of whitening effect

Table 4 shows the whitening effect before and after (D0, D28) the cosmetic sheet of the above-mentioned melted formulation for 4 weeks.

FIG. 4 quantitatively shows the whitening effect before and after the treatment. As a result of measurement of skin pigmentation area using a spectrophotometer (CM3500d), L * and ITA values indicating skin color brightness after 4 weeks (D28) Respectively.

4. Improvement effect after UV irradiation

The results of measurement of UV spot and Brown spot after irradiating ultraviolet rays before and after the dissolving formulation cosmetic sheet for 4 weeks (D0 and D28) are shown in the following Table 5 , FIG. 5 and FIG.

FIG. 5 and FIG. 6 are the results of clinical photographing analysis using the VISIA Complexion Analysis system after the UV irradiation, and the number and score of the UV spot and brown spot after 4 weeks of using the cosmetic sheet of the dissolving formulation (D28) Respectively.

5. Sensory evaluation

Sensory evaluation of sensation on the basis of the results of the questionnaires of the subjects who performed the clinical test was performed and is shown in Table 6 below.

As a result, the skin condition and the efficacy of the cosmetic sheet for dissolving in the test subjects were examined before and after 4 weeks (D0, D28). As a result, satisfaction with moisturizing and whitening was confirmed.

< Experimental Example  3> Hazardous substance analysis

To determine the presence of harmful substances, the cosmetic sheet of the dissolving formulation prepared in Example 2 was subjected to a heavy metal content analysis by the KOTITI test institute.

The results are shown in Table 7 below. As a result of the analysis of the basic 8 heavy metals, heavy metal was not detected in the soluble cosmetic fiber formulation.

As described above, the present invention provides a melted skin sheet for skin contact using the characteristics of gelation of carboxymethylcellulose woven fabric or nonwoven fabric upon moisture contact.

Accordingly, the present invention can provide skin stability and natural decomposition due to use of environmentally and human-friendly cellulosic materials, and can provide market competitiveness due to low cost effect due to abundant use of resources.

Accordingly, the present invention provides a melted formulation product application capable of loading a high content of a cosmetic active ingredient, a water-soluble drug or a natural moisturizing ingredient as a skin oil-soluble ingredient in a skin-contacting fiber sheet of a melted form of a carboxymethylcellulose woven fabric or a nonwoven fabric Respectively.

Furthermore, the present invention provides a product in the form of a dry sheet containing a skin oil-soluble component in a skin-contacting fiber sheet of melted form comprising a carboxymethylcellulose woven fabric or a nonwoven fabric, So that it is possible to solve the discoloration and the problem of discoloration of the formulation due to instability of the conventional skin oil-soluble component.

In addition, a melted form of a cosmetic sheet, a drug delivery patch, or a moisturizing sheet for treating atopy can be provided in the form of a portable size sheet, and skin permeability and absorption of the skin oil-soluble ingredient can be increased during moisture contact.

While the invention has been shown and described with reference to certain exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (9)

A carboxymethylcellulose woven or nonwoven fabric having a substitution degree of 0.8 or more in which a natural cellulose terminal is substituted with a carboxyl group group from a low molecular weight natural cellulose having 200 to 500 repeating units,
Wherein the fibrous shape of the carboxymethyl cellulose woven fabric or nonwoven fabric is finely dispersed in the skin in a state in which the fibrous shape of the carboxymethyl cellulose woven fabric or the nonwoven fabric is not visible to the naked eye due to a physical dispersing force upon contact with moisture. delete The skin sheet for skin contact according to claim 1, wherein the carboxymethylcellulose woven or nonwoven fabric is obtained from natural cellulose having a low weight of 30 to 40 g / m 2. delete The skin sheet for skin contact according to claim 1, wherein the carboxymethyl cellulose woven fabric or nonwoven fabric has a size of 1 x 1 cm to 5 x 5 cm in width and a portable size. A skin-contacting fibrous sheet of a melted form of a fiber of a carboxymethylcellulose woven fabric or a nonwoven fabric of any one of claims 1, 3 and 5, which is selected from the group consisting of moisturizing, elasticity, wrinkle improving and whitening A cosmetic active ingredient which realizes any one of the skin improving functionalities is contained,
Wherein the fibers of the carboxymethyl cellulose woven fabric or the nonwoven fabric are visually dispersed in the skin in a state of being visually dispersed by the physical dispersing force upon moisture contact and dispersed and absorbed by the active ingredients of the cosmetic. The cosmetic sheet as set forth in claim 6, wherein the melted formulation is applied to a portable lotion or mask pack containing the cosmetic active ingredient in the skin-contacting fiber sheet of the melted formulation. A water-soluble drug component is contained in a skin-contacting fibrous sheet of a melted formulation of a carboxymethylcellulose woven or nonwoven fabric of any one of claims 1, 3, and 5,
Wherein the fiber form of the carboxymethylcellulose woven or nonwoven fabric is finely dispersed in a state in which the fibrous shape of the woven or nonwoven fabric is visually observed and the water soluble drug ingredient is dispersed and absorbed by the physical dispersing force upon moisture contact. A skin-contacting fibrous sheet comprising a fibrous shape of the carboxymethylcellulose woven fabric or nonwoven fabric of any one of claims 1, 3, and 5, wherein the natural moisturizing ingredient is contained in an amount of 50 to 80%
A moisturizing sheet for the treatment of atopic dermatitis, wherein the fibrous form of the carboxymethylcellulose woven or nonwoven fabric is finely dispersed in the skin in a state in which the fibrous form of the carboxymethylcellulose woven or nonwoven fabric is not visually observed, and natural moisturizing ingredients are dispersed and absorbed by the physical dispersing force upon moisture contact.

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