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KR101873303B1 - 타액 내 dna 메틸화를 이용한 연령 예측 방법 - Google Patents

타액 내 dna 메틸화를 이용한 연령 예측 방법 Download PDF

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Publication number
KR101873303B1
KR101873303B1 KR1020170010915A KR20170010915A KR101873303B1 KR 101873303 B1 KR101873303 B1 KR 101873303B1 KR 1020170010915 A KR1020170010915 A KR 1020170010915A KR 20170010915 A KR20170010915 A KR 20170010915A KR 101873303 B1 KR101873303 B1 KR 101873303B1
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South Korea
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methylation
age
value
marker
subject
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English (en)
Korean (ko)
Inventor
이환영
홍새롬
정상은
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연세대학교 산학협력단
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Priority to PCT/KR2018/000986 priority patent/WO2018139826A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2533/00—Reactions characterised by the enzymatic reaction principle used
    • C12Q2533/10—Reactions characterised by the enzymatic reaction principle used the purpose being to increase the length of an oligonucleotide strand
    • C12Q2533/101—Primer extension
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020170010915A 2017-01-24 2017-01-24 타액 내 dna 메틸화를 이용한 연령 예측 방법 Expired - Fee Related KR101873303B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020170010915A KR101873303B1 (ko) 2017-01-24 2017-01-24 타액 내 dna 메틸화를 이용한 연령 예측 방법
PCT/KR2018/000986 WO2018139826A1 (fr) 2017-01-24 2018-01-23 Procédé de prédiction de l'âge faisant appel à la méthylation de l'adn

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020170010915A KR101873303B1 (ko) 2017-01-24 2017-01-24 타액 내 dna 메틸화를 이용한 연령 예측 방법

Publications (1)

Publication Number Publication Date
KR101873303B1 true KR101873303B1 (ko) 2018-07-02

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KR1020170010915A Expired - Fee Related KR101873303B1 (ko) 2017-01-24 2017-01-24 타액 내 dna 메틸화를 이용한 연령 예측 방법

Country Status (2)

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KR (1) KR101873303B1 (fr)
WO (1) WO2018139826A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200101084A (ko) * 2019-02-19 2020-08-27 바이오코아 주식회사 체액을 이용한 연령 추적 방법
KR20220008133A (ko) * 2020-07-13 2022-01-20 대한민국(관리부서: 행정안전부 국립과학수사연구원장) 뼈를 이용한 연령 예측을 위한 방법 및 마커
CN114464255A (zh) * 2022-01-28 2022-05-10 北京果壳生物科技有限公司 一种基于dna甲基化水平数据的甲基化年龄评估方法
CN114774557A (zh) * 2022-03-02 2022-07-22 华中科技大学 用于推断中国汉族人群个体年龄的组合标志物及其应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210388442A1 (en) * 2018-10-08 2021-12-16 Thomas J.C. Matzen Gmbh Method and devices for age determination
WO2022058980A1 (fr) 2020-09-21 2022-03-24 Insilico Medicine Ip Limited Signatures de vieillissement basées sur des données de méthylation et procédé de détermination d'une horloge de vieillissement biologique
CN116064836A (zh) * 2022-09-28 2023-05-05 公安部物证鉴定中心 一种基于微滴数字pcr的唾液样本个体生物学年龄推断方法及检测体系

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015048665A2 (fr) * 2013-09-27 2015-04-02 The Regents Of The University Of California Procédé permettant d'estimer l'âge de tissus et de types cellulaires sur la base de marqueurs épigénétiques
US20150259742A1 (en) * 2012-11-09 2015-09-17 The Regents Of The University Of California Methods for predicting age and identifying agents that induce or inhibit premature aging

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012162139A1 (fr) * 2011-05-20 2012-11-29 The Regents Of The University Of California Méthode pour estimer l'âge d'un individu sur la base de marqueurs épigénétiques dans un échantillon biologique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150259742A1 (en) * 2012-11-09 2015-09-17 The Regents Of The University Of California Methods for predicting age and identifying agents that induce or inhibit premature aging
WO2015048665A2 (fr) * 2013-09-27 2015-04-02 The Regents Of The University Of California Procédé permettant d'estimer l'âge de tissus et de types cellulaires sur la base de marqueurs épigénétiques

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Renata Zbiec-Piekarska et al. Forensic Science International: Genetics 17 (2015) 173-179.
Sae Rom Hong et al. Forensic Science International: Genetics 29 (2017) 118-125.
Shaza B Zaghlool et al. Clinical Epigenetics (2015) 7:6 (12 pages).

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200101084A (ko) * 2019-02-19 2020-08-27 바이오코아 주식회사 체액을 이용한 연령 추적 방법
KR102170423B1 (ko) * 2019-02-19 2020-10-27 바이오코아 주식회사 체액을 이용한 연령 추적 방법
KR20220008133A (ko) * 2020-07-13 2022-01-20 대한민국(관리부서: 행정안전부 국립과학수사연구원장) 뼈를 이용한 연령 예측을 위한 방법 및 마커
KR102401159B1 (ko) 2020-07-13 2022-05-24 대한민국 뼈를 이용한 연령 예측을 위한 방법 및 마커
CN114464255A (zh) * 2022-01-28 2022-05-10 北京果壳生物科技有限公司 一种基于dna甲基化水平数据的甲基化年龄评估方法
CN114774557A (zh) * 2022-03-02 2022-07-22 华中科技大学 用于推断中国汉族人群个体年龄的组合标志物及其应用

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