KR102084602B1 - Foaming tablet for cleaning oral cavity having improved foamability and stability - Google Patents
Foaming tablet for cleaning oral cavity having improved foamability and stability Download PDFInfo
- Publication number
- KR102084602B1 KR102084602B1 KR1020180136325A KR20180136325A KR102084602B1 KR 102084602 B1 KR102084602 B1 KR 102084602B1 KR 1020180136325 A KR1020180136325 A KR 1020180136325A KR 20180136325 A KR20180136325 A KR 20180136325A KR 102084602 B1 KR102084602 B1 KR 102084602B1
- Authority
- KR
- South Korea
- Prior art keywords
- foam
- weight
- oral cleaning
- stability
- foamed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 56
- 238000005187 foaming Methods 0.000 title abstract description 19
- 210000000214 mouth Anatomy 0.000 title abstract description 7
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- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 31
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 31
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 27
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 27
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 27
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 26
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 26
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 26
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 17
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- 239000008101 lactose Substances 0.000 claims description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims description 5
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 5
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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Abstract
Description
본 발명은 발포성 및 안정성이 향상된 구강 세정용 발포정에 관한 것이다. 더욱 상세하게는 구강 세정용 발포정의 발포성 및 안정성을 향상시키기 위해 기재 물질로서 미세결정셀룰로오스에 말토덱스트린 및 베타시클로덱스트린을 코팅시킨 혼합 기재를 사용하고 발포성 향상을 위해 혼합 기재의 붕해제로 크로스포비돈을 첨가하고 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키기 위해 음이온 계면활성제인 라우릴황산나트륨을 조성물 내에 첨가시켜 제조된 발포성 및 안정성이 향상된 구강 세정용 발포정에 관한 것이다. The present invention relates to foam tablets for oral cleaning with improved foamability and stability. More specifically, a mixed substrate in which maltodextrin and betacyclodextrin are coated on microcrystalline cellulose as a base material to improve the foamability and stability of the foam for oral cleaning tablets, and crospovidone as a disintegrant of the mixed substrate to improve foamability. The present invention relates to an effervescent tablet having improved foamability and stability, which is prepared by adding sodium lauryl sulfate, an anionic surfactant, into a composition to add bubbles and to generate bubbles together with saliva and water to improve intraoral cleaning ability.
치약은 우수한 연마작용으로 치아의 미백 및 플라그의 제거가 가능하나 구강 청정효과와 구강 내의 플라그 제거를 위해서는 물, 칫솔 등의 부가적인 도구와 시간이 필요하다. 한편 부가적인 도구를 제거시킨 액체형 구강청정제는 그 자제의 용량이 크고 부수적으로 따르는 컵과 같은 용기도 필요한 경우가 있어 휴대하기가 불편한 단점이 있다.Toothpaste can be used for whitening teeth and removing plaque due to its excellent polishing, but additional tools and time such as water and toothbrush are needed for the oral cleansing effect and the removal of plaque in the mouth. On the other hand, liquid oral cleansers with additional tools removed have a disadvantage in that they are inconvenient to carry, as the containers of such cups need to be accompanied by a large volume of the materials.
이에 본 발명자는 이러한 치약 및 액체형 구강청정제의 단점을 개선하기 위해 대한민국 특허등록 제10-294515호 '구강청정용 발포성 정제 및 그의 제조방법'에서 "결정셀룰로오스, 분말셀룰로오스 및 식이섬유질로 구성된 군에서 선택된 1종 또는 2종 이상의 혼합물인 기재 30∼70 중량%에 탄산수소나트륨, 탄산수소암모늄, 탄산수소칼륨 및 탄산철로 구성된 군에서 선택된 1종 또는 2종 이상의 혼합물인 발포제 10∼50 중량%, 이산화규소, 인산일수소칼슘, 탄산칼슘, 수산화알루미늄, 침강실리카, 함수규산, 함수알루미나, 실리카겔, 불용성메타인산나트륨, 지르코늄실리케이트, 중조, 알루미노실리케이트로 이루어진 군에서 선택된 1종 또는 2종 이상의 혼합물인 연마제 5∼20 중량%, 구연산, 주석산, 사과산, 글루콘산, 아스코르빈산, 호박산 및 프로피온산으로 구성된 군에서 선택된 1종 또는 2종 이상의 혼합물인 유기산 3∼20 중량% 및 불화나트륨 또는 불소계화합물인 충치예방제 0.05∼1.0 중량% 및 적량의 향료, 적량의 감미제 및 색소를 혼합하고 강도를 주어 타정시킴을 특징으로 하는 구강청정용 발포성 정제 및 그의 제조방법"을 개시한 바 있다. In order to improve the drawbacks of toothpaste and liquid mouthwashes, the present inventors have selected from the group consisting of crystalline cellulose, powdered cellulose and dietary fiber in Korean Patent Registration No. 10-294515 'Foaming tablets for oral cleaning and preparation method thereof'. 30 to 70% by weight of the substrate, which is one or more mixtures, 10 to 50% by weight of the blowing agent which is one or two or more mixtures selected from the group consisting of sodium bicarbonate, ammonium bicarbonate, potassium hydrogen carbonate and iron carbonate, and silicon dioxide Abrasive, one or two or more selected from the group consisting of calcium monohydrogen phosphate, calcium carbonate, aluminum hydroxide, precipitated silica, hydrous silicate, hydrous alumina, silica gel, insoluble sodium phosphate, zirconium silicate, sodium bicarbonate, and aluminosilicate 5-20% by weight, citric acid, tartaric acid, malic acid, gluconic acid, ascorbic acid, succinic acid and propionic acid 3-20% by weight of one or two or more mixtures selected from the group consisting of organic acids and 0.05-1.0% by weight of sodium fluoride or fluorine compounds and a suitable amount of flavors, sweeteners and pigments, followed by tableting Oral cleansing foam tablets and a method for preparing the same "have been disclosed.
상기 특허문헌에 개시된 구강청정용 발포성 정제의 경우 치주성 병원성 미생물에 대한 우수한 살균 활성과 구강 내의 구취 제거 및 맛과 향 면에서 겔 상의 일반 치약이나 액상의 구강청정용 액제보다 우수한 효과를 나타내었으나 구강 세정용 발포성 정제의 발포성과 안정성이 충분하지 않아 그 상용화에 문제가 있었던 것이다. The foam tablets for oral cleaning disclosed in the patent document showed superior sterilizing activity against periodontal pathogenic microorganisms, removing bad breath in the oral cavity, and taste and flavor than the general toothpaste on the gel or liquid oral cleaning solution. There was a problem in the commercialization because the foamability and stability of the washing foamable tablet is not sufficient.
이에 본 발명자는 종래 구강청정용 발포성 정제의 발포성 및 안정성의 개선을 위해 노력하던 중 미세결정 셀룰로오스 코어 물질에 말토덱스트린과 베타시클로덱스트린을 코팅시킨 혼합 기재를 발포 기재로 사용하고 발포성 향상을 위해 혼합 기재의 붕해제로 크로스포비돈을 첨가하고 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키기 위해 음이온 계면활성제인 라우릴황산나트륨을 조성물 내에 첨가시켜 발포성 및 안정성이 향상된 구강 세정용 발포정을 개발함으로써 본 발명을 완성하게 된 것이다. Therefore, the present inventors are using a mixed substrate coated with maltodextrin and betacyclodextrin on a microcrystalline cellulose core material as a foaming substrate while trying to improve the foamability and stability of a conventional oral cleaning foamable tablet, and a mixed substrate to improve foamability. By adding crospovidone as a disintegrating agent and adding bubbles with saliva and water to improve the oral cleansing ability, an anionic surfactant sodium lauryl sulfate was added to the composition to develop an effervescent and stable foam for oral cleaning. The present invention has been completed.
본 발명이 해결하고자 하는 과제는 미세결정 셀룰로오스 코어 물질에 말토덱스트린과 베타시클로덱스트린을 코팅시킨 혼합 기재를 발포 기재로 적용하고, 발포성 향상을 위해 혼합 기재의 붕해제로 크로스포비돈을 첨가하고 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키기 위해 음이온 계면활성제인 라우릴황산나트륨을 조성물 내에 첨가시켜 발포성 및 안정성이 향상된 구강 세정용 발포정을 개발코자 한 것이다. The problem to be solved by the present invention is to apply a mixed substrate coated with maltodextrin and betacyclodextrin to the microcrystalline cellulose core material as a foamed substrate, adding crospovidone as a disintegrant of the mixed substrate in order to improve the foamability, saliva, water In addition, it is intended to develop an oral cleaning foam having improved foamability and stability by adding an anionic surfactant sodium lauryl sulfate in the composition in order to create bubbles to improve the oral cleaning ability.
본 발명의 목적은 ⅰ) 20 ~ 35 중량%의 발포 기재; ⅱ) 20 ~ 25 중량%의 탄산수소나트륨 발포제; ⅲ) 5 ~ 15 중량%의 경질무수규산 또는 무수인산수소칼슘에서 선택된 1종 이상의 연마제; ⅳ) 5 ~ 10 중량%의 구연산; ⅴ) 0.05 ~ 0.5 중량%의 라우릴황산나트륨 기포제; ⅵ) 0.1 ~ 1.0 중량%의 크로스포비돈 붕해제; 및 ⅶ) 0.05 ~ 0.5 중량%의 불소계 충치 예방제;를 포함하는 발포성 및 안정성이 향상된 구강 세정용 발포정에 있어서, 상기 발포 기재는 미세결정 셀룰로오스 코어 물질에 말토덱스트린 및 베타시클로덱스트린을 코팅시킨 혼합 발포 기재이며, 상기 발포 기재의 발포성과 안정성을 향상시키기 위해 발포정 내의 발포 기재의 함량을 35 중량% 이하로 감소시킨 발포성 및 안정성이 향상된 구강 세정용 발포정을 제공하는 것이다. It is an object of the present invention to provide a composition comprising i) 20 to 35% by weight of a foamed substrate; Ii) 20 to 25% by weight sodium hydrogen carbonate blowing agent; Viii) at least one abrasive selected from 5 to 15% by weight of hard silicic anhydride or anhydrous calcium hydrogen phosphate; Iii) 5 to 10 weight percent citric acid; Iii) 0.05-0.5% by weight sodium lauryl sulfate foaming agent; Viii) 0.1-1.0 wt% crospovidone disintegrant; And iii) 0.05 to 0.5% by weight of a fluorine-based tooth decay preventive agent, comprising: a foamed tablet for oral cleaning with improved foamability and stability, wherein the foam base is a mixed foam in which maltodextrin and betacyclodextrin are coated on a microcrystalline cellulose core material It is a substrate, and in order to improve the foamability and stability of the foamed substrate to provide a foamed tablet for oral cleaning with improved foamability and stability by reducing the content of the foamed substrate in the foamed tablet to 35% by weight or less.
이때 상기 발포 기재는 7 ~ 12 중량%의 미세결정 셀룰로오스 코어 물질에 8 ~ 14 중량%의 말토덱스트린과 3 ~ 6 중량%의 베타시클로덱스트린을 코팅시켜 제조됨을 특징으로 한다. At this time, the foamed substrate is characterized in that it is prepared by coating 8 to 14% by weight of maltodextrin and 3 to 6% by weight of betacyclodextrin on 7 to 12% by weight of the microcrystalline cellulose core material.
또한 상기 발포 기재인 말토덱스트린 및 베타시클로덱스트린 코팅 미세결정 셀룰로오스의 1.0 중량% 수용액의 점도는 Brookfield 회전형 점도계로 20 rpm/분 회전 속도로 측정시 20 ~ 70 mPa·s임을 특징으로 한다.In addition, the viscosity of the 1.0 wt% aqueous solution of the maltodextrin and betacyclodextrin-coated microcrystalline cellulose of the foamed substrate is characterized in that 20 to 70 mPa · s as measured at 20 rpm / min rotational speed with a Brookfield rotary viscometer.
한편 상기 구연산과 탄산수소나트륨 발포제는 산 염기 반응을 통해 이산화탄소 가스를 발포시키며 음이온 계면활성제인 라우릴황산나트륨은 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키며, 상기 크로스포비돈 붕해제는 발포 기재의 붕해를 촉진시켜 발포성 및 안정성을 향상시킴을 특징으로 한다.Meanwhile, the citric acid and sodium bicarbonate blowing agent foam carbon dioxide gas through an acid base reaction, and sodium lauryl sulfate, an anionic surfactant, creates bubbles together with saliva and water to improve cleaning ability in the oral cavity, and the crospovidone disintegrant is foamed. It is characterized by promoting disintegration of the substrate to improve foamability and stability.
한편 본 발명의 구강 세정용 발포정은 (a) 스테아르산 마그네슘 활택제; (b) D-만니톨 발포성 강화제; (c) 오렌지향, 딸기향, 포도향, 페퍼민트오일, 스피아민트오일, 멘톨, 카르본, 아네롤, 오이게놀, 윈터그린, 세이지 또는 유칼립토오일에서 선택된 1종 이상의 향료; (d) 락토오스, 말토오스, 락티톨, 사카린나트륨, 아스파탐, 스테비오사이드 또는 감초산에서 선택된 1종 이상의 감미료; 또는 (e) 세이지, 로즈마리, 녹차, 감추출물 또는 샨피니온추출물에서 선택된 1종 이상의 구취제거제; 에서 선택된 1종 이상의 첨가제를 더욱 포함함을 특징으로 한다.On the other hand, foaming tablets for oral cleaning of the present invention (a) magnesium stearate lubricant; (b) D-mannitol foam enhancer; (c) at least one flavor selected from orange, strawberry, grape, peppermint oil, spearmint oil, menthol, carbon, anerol, eugenol, wintergreen, sage or eucalypto oil; (d) at least one sweetener selected from lactose, maltose, lactitol, sodium saccharin, aspartame, stevioside or licoriceic acid; Or (e) at least one deodorant selected from sage, rosemary, green tea, persimmon extract or shanpinion extract; It further comprises at least one additive selected from.
본 발명의 효과는 미세결정 셀룰로오스 코어 물질에 말토덱스트린과 베타시클로덱스트린을 코팅시킨 혼합 기재를 발포 기재로 적용하고, 발포성 향상을 위해 혼합 기재의 붕해제로 크로스포비돈을 첨가하고 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키기 위해 음이온 계면활성제인 라우릴황산나트륨을 조성물 내에 첨가시켜 발포성 및 안정성이 향상된 구강 세정용 발포정을 제공하는 것이다.The effect of the present invention is to apply a mixed substrate coated with maltodextrin and betacyclodextrin to the microcrystalline cellulose core material as a foamed substrate, and to add foam povidone as a disintegrant of the mixed substrate in order to improve the foamability and bubbles with saliva, water Sodium lauryl sulfate, an anionic surfactant, is added to the composition in order to improve the oral cleansing ability, thereby providing effervescent tablets having improved foamability and stability.
본 발명은 ⅰ) 20 ~ 35 중량%의 발포 기재; ⅱ) 20 ~ 25 중량%의 탄산수소나트륨 발포제; ⅲ) 5 ~ 15 중량%의 경질무수규산 또는 무수인산수소칼슘에서 선택된 1종 이상의 연마제; ⅳ) 5 ~ 10 중량%의 구연산; ⅴ) 0.05 ~ 0.5 중량%의 라우릴황산나트륨 기포제; ⅵ) 0.1 ~ 1.0 중량%의 크로스포비돈 붕해제; 및 ⅶ) 0.05 ~ 0.5 중량%의 불소계 충치 예방제;를 포함하는 발포성 및 안정성이 향상된 구강 세정용 발포정에 있어서, 상기 발포 기재는 미세결정 셀룰로오스 코어 물질에 말토덱스트린 및 베타시클로덱스트린을 코팅시킨 혼합 발포 기재이며, 상기 발포 기재의 발포성과 안정성을 향상시키기 위해 발포정 내의 발포 기재의 함량을 35 중량% 이하로 감소시킨 발포성 및 안정성이 향상된 구강 세정용 발포정에 관한 것이다.The present invention comprises: i) 20 to 35% by weight of the foam substrate; Ii) 20 to 25% by weight sodium hydrogen carbonate blowing agent; Viii) at least one abrasive selected from 5 to 15% by weight of hard silicic anhydride or anhydrous calcium hydrogen phosphate; Iii) 5 to 10 weight percent citric acid; Iii) 0.05-0.5% by weight sodium lauryl sulfate foaming agent; Viii) 0.1-1.0 wt% crospovidone disintegrant; And iii) 0.05 to 0.5% by weight of a fluorine-based tooth decay preventive agent, comprising: a foamed tablet for oral cleaning with improved foamability and stability, wherein the foam base is a mixed foam in which maltodextrin and betacyclodextrin are coated on a microcrystalline cellulose core material It is a substrate, and relates to a foaming tablet for oral cleaning with improved foamability and stability by reducing the content of the foamed substrate in the foamed tablet to 35% by weight or less in order to improve the foamability and stability of the foamed substrate.
한편 본 발명의 구강 세정용 발포정은 (a) 스테아르산 마그네슘 활택제; (b) D-만니톨 발포성 강화제; (c) 오렌지향, 딸기향, 포도향, 페퍼민트오일, 스피아민트오일, 멘톨, 카르본, 아네롤, 오이게놀, 윈터그린, 세이지 또는 유칼립토오일에서 선택된 1종 이상의 향료; (d) 락토오스, 말토오스, 락티톨, 사카린나트륨, 아스파탐, 스테비오사이드 또는 감초산에서 선택된 1종 이상의 감미료; 또는 (e) 세이지, 로즈마리, 녹차, 감추출물 또는 샨피니온추출물에서 선택된 1종 이상의 구취제거제; 에서 선택된 1종 이상의 첨가제를 더욱 포함함을 특징으로 한다.On the other hand, foaming tablets for oral cleaning of the present invention (a) magnesium stearate lubricant; (b) D-mannitol foam enhancer; (c) at least one flavor selected from orange, strawberry, grape, peppermint oil, spearmint oil, menthol, carbon, anerol, eugenol, wintergreen, sage or eucalypto oil; (d) at least one sweetener selected from lactose, maltose, lactitol, sodium saccharin, aspartame, stevioside or licoriceic acid; Or (e) at least one deodorant selected from sage, rosemary, green tea, persimmon extract or shanpinion extract; It further comprises at least one additive selected from.
한편 본 발명의 발포성 및 안정성이 향상된 구강 세정용 발포정은 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키기 위해 음이온 계면활성제인 라우릴황산나트륨 기포제를 0.05 ~ 0.5 중량% 포함하며 혼합 기재의 발포성을 향상시키기 위해 0.1 ~ 1.0 중량%의 크로스포비돈 붕해제를 포함한다. Meanwhile, the foaming tablet for oral cleaning having improved foamability and stability according to the present invention contains 0.05 to 0.5% by weight of an anionic surfactant sodium lauryl sulfate foaming agent in order to generate bubbles together with saliva and water to improve the oral cleaning power, and foamability of the mixed substrate. 0.1 to 1.0% by weight of crospovidone disintegrant to improve.
이하 본 발명에 사용된 구강 세정용 발포 기재에 대해 더욱 상세히 설명한다. Hereinafter will be described in more detail with respect to the foam substrate for oral cleaning used in the present invention.
본 발명에 사용된 구강 세정용 발포 기재는 구강 세정용 발포정 전체 중량 대비 20 ~ 35 중량%를 사용한다. 7 ~ 12 중량%의 미세결정 셀룰로오스 코어 물질에 8 ~ 14 중량%의 말토덱스트린과 3 ~ 6 중량%의 베타시클로덱스트린을 코팅시켜 제조되는 것이 바람직하다.The foam base for oral cleaning used in the present invention uses 20 to 35% by weight relative to the total weight of the foam for oral cleaning. It is preferably prepared by coating 8-14% by weight of maltodextrin and 3-6% by weight of betacyclodextrin on 7-12% by weight of the microcrystalline cellulose core material.
또한 말토덱스트린 및 베타시클로덱스트린 코팅 미세결정 셀룰로오스의 평균 입자 크기는 수 분산시 1 내지 50 ㎛이며 바람직하게는 3 내지 20 ㎛이다. In addition, the average particle size of maltodextrin and betacyclodextrin coated microcrystalline cellulose is 1-50 μm in water dispersion and preferably 3-20 μm.
또한 이때 사용되는 미세결정 셀룰로오스는 물과는 낮은 친화도를 나타내나 미세결정 셀룰로오스 표면을 수용성 말토덱스트린과 베타시클로덱스트린으로 코팅시킴으로써 물에서 콜로이드 형태로 분산 용해된다. In addition, the microcrystalline cellulose used at this time has a low affinity with water, but is dispersed and dissolved in colloidal form in water by coating the surface of the microcrystalline cellulose with water-soluble maltodextrin and betacyclodextrin.
또한 상기 말토덱스트린 및 베타시클로덱스트린 코팅 미세결정 셀룰로오스는 적정한 점도의 물성이 요구되며 그 바람직한 점도는 1.0 중량% 수용액의 말토덱스트린 및 베타시클로덱스트린 코팅 미세결정 셀룰로오스를 20℃에서 Brookfield 회전형 점도계로 20 rpm/분 회전 속도로 측정시 20 ~ 70 mPa·s인 것이다. In addition, the maltodextrin and betacyclodextrin-coated microcrystalline cellulose is required to have a suitable physical properties of the viscosity, the preferred viscosity of the 1.0 wt% aqueous solution of maltodextrin and betacyclodextrin-coated microcrystalline cellulose at 20 ℃ 20 rpm to Brookfield rotary viscometer It is 20 to 70 mPa · s when measured at a rotational speed per minute.
한편 미세결정 셀룰로오스의 코팅 물질로 사용되는 말토덱스트린은 흰색의 미세 분말로서 수분 함량은 4.0 ~ 8.0 % 범위이고 덱스트로스 당량(DE)은 12.0 ~ 20.0 범위인 것이 바람직하다. 또한 말토덱스트린은 낮은 수분 함량으로 인한 저흡습성을 지니며 용해시 분산성이 우수하다. Maltodextrin, which is used as a coating material for microcrystalline cellulose, is a white fine powder, and the water content is in the range of 4.0 to 8.0%, and the dextrose equivalent weight (DE) is preferably in the range of 12.0 to 20.0. In addition, maltodextrin has low hygroscopicity due to low water content and disperses well when dissolved.
또한 미세결정 셀룰로오스의 코팅 물질로 사용되는 베타시클로덱스트린은 소수성 분자와 포접 복합체를 형성하는 것으로 알려져 있고 본 발명의 조성 내에서는 각각의 조성 성분의 용해성을 증진시켜 구강세정용 발포정의 발포성과 안정성을 향상시킨다.In addition, betacyclodextrin, which is used as a coating material for microcrystalline cellulose, is known to form a clathrate complex with hydrophobic molecules and improves the solubility of each component in the composition of the present invention to improve the foamability and stability of the foam tablet for oral cleaning. Let's do it.
한편 본 발명의 말토덱스트린 및 베타시클로덱스트린 코팅 미세결정 셀룰로오스는 이와 유사하게 표면 처리된 상업용으로 이용 가능한 미세결정 셀룰로오스를 사용할 수도 있다. 예를 들면 일본 아사히 카세이 사의 Ceolus RC 시리즈 또는 SC 시리즈의 표면 처리된 미세결정 셀룰로오스를 사용할 수도 있다. Meanwhile, maltodextrin and betacyclodextrin coated microcrystalline cellulose of the present invention may similarly use a commercially available microcrystalline cellulose having a surface treatment. For example, surface-treated microcrystalline cellulose of Ceolus RC series or SC series of Asahi Kasei Co., Ltd., Japan may be used.
본 발명에 따른 발포제는 약산성 수용액 내에서 붕해되어 이산화탄소를 발생시키는 것은 사용 가능하나 탄산수소나트륨을 발포제로 사용하는 것이 바람직하다. 바람직한 발포제의 함량은 발포정 전체 중량 대비 20 ~ 25 중량% 정도이다. Although the blowing agent according to the present invention can be used to generate carbon dioxide by disintegrating in a weakly acidic aqueous solution, it is preferable to use sodium bicarbonate as the blowing agent. The content of the preferred blowing agent is about 20 to 25% by weight based on the total weight of the foam tablet.
또한 본 발명에 따른 유기산인 구연산은 물 또는 타액에 의해 산성 수용액을 형성하여 발포제로 사용하는 탄산수소나트륨과 같은 탄산염을 분해시켜 이산화탄소를 발생시키게 한다. In addition, citric acid, an organic acid according to the present invention, forms an acidic aqueous solution with water or saliva to decompose carbonates such as sodium bicarbonate used as a blowing agent to generate carbon dioxide.
바람직한 유기산의 함량은 발포정 전체 중량 대비 5 ~ 10 중량% 정도이다. 또한 유기산은 수분 함량을 줄일 수 있도록 무수물의 형태로 첨가하는 것도 가능하다.The content of the preferred organic acid is about 5 to 10% by weight based on the total weight of the foamed tablet. Organic acids may also be added in the form of anhydrides to reduce the water content.
본 발명의 구강 세정용 발포정은 5 ~ 15 중량%의 경질무수규산 또는 인산수소칼슘에서 선택된 연마제를 포함한다. Foamed tablet for oral cleaning of the present invention comprises an abrasive selected from 5 to 15% by weight of hard silicic anhydride or calcium hydrogen phosphate.
한편 연마제로서 칼슘실리케이트를 사용하는 것도 가능하다. 칼슘 실리케이트는 CaSiO3 화학식을 가지는 물질로서 결정형에 따라 오르소-칼슘실리케이트, 메타-칼슘실리케이트, 알파-칼슘실리케이트, 트리클리닉-칼슘실리케이트 등으로 분류될 수 있으며 비결정형 칼슘실리케이트도 사용 가능하다. On the other hand, it is also possible to use calcium silicate as an abrasive. Calcium silicate is a substance having the formula CaSiO 3 and can be classified into ortho-calcium silicate, meta-calcium silicate, alpha-calcium silicate, triclinic-calcium silicate and the like according to the crystal form, and amorphous calcium silicate may also be used.
본 발명에 사용할 수 있는 경질무수규산은 표면적이 180 ~ 200 m2/g 범위이고 밀도가 1.8 ~ 2.4 g/cc 범위인 것이 바람직하다. The hard silicic anhydride that can be used in the present invention preferably has a surface area of 180 to 200 m 2 / g and a density of 1.8 to 2.4 g / cc.
또한 본 발명에 따른 연마제는 치아의 법랑질을 연마하여 플라그 또는 음식물 찌꺼기 등을 제거시킴을 특징으로 한다.In addition, the abrasive according to the present invention is characterized by removing the plaque or food debris by grinding the enamel of the tooth.
한편 본 발명의 발포성 및 안정성이 향상된 구강 세정용 발포정은 타액, 물과 함께 기포를 생성시켜 구강 내 세정력을 향상시키기 위해 음이온 계면활성제인 라우릴황산나트륨 기포제를 0.05 ~ 0.5 중량% 포함하며 혼합 기재의 발포성을 향상시키기 위해 0.1 ~ 1.0 중량%의 크로스포비돈 붕해제를 포함한다. Meanwhile, the foaming tablet for oral cleaning having improved foamability and stability according to the present invention contains 0.05 to 0.5% by weight of an anionic surfactant sodium lauryl sulfate foaming agent in order to generate bubbles together with saliva and water to improve the oral cleaning power, and foamability of the mixed substrate. 0.1 to 1.0% by weight of crospovidone disintegrant to improve.
또한 본 발명의 발포성 및 안정성이 향상된 구강 세정용 발포정은 0.05 ~ 0.5 중량%의 불소계 충치 예방제를 포함한다. 불소계 충치 예방제는 충치 예방을 목적으로 불소 이온을 포함한 화합물을 사용한다. 불소계 충치 예방제로는 불화나트륨, 일불소인산나트륨, 불화주석, 불화아민에서 선택된 1종 이상을 사용할 수 있다. In addition, foam tablets for oral cleaning improved in the foamability and stability of the present invention contains a fluorine-based caries preventive agent of 0.05 to 0.5% by weight. Fluorine-based tooth decay preventive uses a compound containing fluorine ions for the purpose of preventing tooth decay. As the fluorine-based caries preventive agent, at least one selected from sodium fluoride, sodium monofluorophosphate, tin fluoride, and amine fluoride may be used.
불소계 충치 예방제에 함유된 바람직한 불소 이온의 함량은 800 ~ 1600 ppm 범위이다. The preferred content of fluorine ions in the fluorine-based caries preventer is in the range from 800 to 1600 ppm.
또한 본 발명의 구강 세정용 발포정은 (a) 스테아르산 마그네슘 활택제; (b) D-만니톨 발포성 강화제; (c) 오렌지향, 딸기향, 포도향, 페퍼민트오일, 스피아민트오일, 멘톨, 카르본, 아네롤, 오이게놀, 윈터그린, 세이지 또는 유칼립토오일에서 선택된 1종 이상의 향료; (d) 락토오스, 말토오스, 락티톨, 사카린나트륨, 아스파탐, 스테비오사이드 또는 감초산에서 선택된 1종 이상의 감미료; 또는 (e) 세이지, 로즈마리, 녹차, 감추출물 또는 샨피니온추출물에서 선택된 1종 이상의 구취제거제; 에서 선택된 1종 이상의 첨가제를 더욱 포함할 수 있다. In addition, foaming tablets for oral cleaning of the present invention (a) magnesium stearate lubricant; (b) D-mannitol foam enhancer; (c) at least one flavor selected from orange, strawberry, grape, peppermint oil, spearmint oil, menthol, carbon, anerol, eugenol, wintergreen, sage or eucalypto oil; (d) at least one sweetener selected from lactose, maltose, lactitol, sodium saccharin, aspartame, stevioside or licoriceic acid; Or (e) at least one deodorant selected from sage, rosemary, green tea, persimmon extract or shanpinion extract; It may further comprise one or more additives selected from.
본 발명에 사용되는 스테아르산마그네슘 활택제는 정제 제조시 타정 과정에서 타정기의 펀치에 이물이 삽입되는 것을 방지해주는 역할을 한다. 활택제의 함량은 발포제 전체 중량 대비 0.5 ~ 1.5 중량% 범위가 바람직하다. The magnesium stearate glidant used in the present invention serves to prevent foreign matter from being inserted into the punch of the tableting machine during the tableting process during tablet manufacture. The amount of the lubricant is preferably in the range of 0.5 to 1.5% by weight based on the total weight of the blowing agent.
본 발명은 오렌지향, 딸기향, 포도향, 페퍼민트오일, 스피아민트오일, 멘톨, 카르본, 아네롤, 오이게놀, 윈터그린, 세이지 또는 유칼립토오일에서 선택된 1종 이상의 향료를 첨가할 수 있다. 항료의 함량은 발포제 전체 중량 대비 1.5 ~ 3.0 중량% 범위가 바람직하다. The present invention may add at least one flavor selected from orange flavor, strawberry flavor, grape flavor, peppermint oil, spearmint oil, menthol, carbon, anerol, eugenol, wintergreen, sage or eucalypto oil. The content of the paint is preferably in the range of 1.5 to 3.0% by weight based on the total weight of the blowing agent.
본 발명은 락토오스, 말토오스, 락티톨, 사카린나트륨, 아스파탐, 스테비오사이드 또는 감초산에서 선택된 1종 이상의 감미료를 첨가할 수 있다. 감미료의 함량은 발포제 전체 중량 대비 0.8 ~ 1.5 중량% 범위가 바람직하다. The present invention may add one or more sweeteners selected from lactose, maltose, lactitol, sodium saccharin, aspartame, stevioside or licoriceic acid. The sweetener content is preferably in the range of 0.8 to 1.5% by weight based on the total weight of the blowing agent.
본 발명은 세이지, 로즈마리, 녹차, 감추출물 또는 샨피니온추출물에서 선택된 1종 이상의 구취제거제를 첨가할 수 있다. 구취제거제의 함량은 발포제 전체 중량 대비 0.1 ~ 0.5 중량% 범위가 바람직하다. The present invention may add at least one bad breath remover selected from sage, rosemary, green tea, persimmon extract or shanpinion extract. The content of the bad breath remover is preferably in the range of 0.1 to 0.5% by weight based on the total weight of the blowing agent.
이하 본 발명을 제조실시예, 제조비교예 및 실시예를 통해 더욱 상세히 설명한다. Hereinafter, the present invention will be described in more detail with reference to Preparation Examples, Preparation Examples and Examples.
(제조실시예) 본 발명의 구강 세정용 발포정의 제조 Preparation Example Preparation of Foamed Tablet for Oral Washing of the Present Invention
(단계 1) 혼합 기재의 제조(Step 1) Preparation of Mixed Substrate
80 mg의 미세결정 셀룰로오스를 코어 물질로 하고 110 mg의 말토덱스트린 및 45 mg의 베타시클로덱스트린을 코팅 물질로 하여 미세결정 셀룰로오스에 말토덱스트린과 베타시클로덱스트린을 코팅기 내에서 흡식 혼합법으로 분산시켜 혼합 기재 235 mg을 제조한다. A mixed substrate was prepared by dispersing maltodextrin and betacyclodextrin in a coating machine by suction mixing method using 80 mg of microcrystalline cellulose as a core material and 110 mg of maltodextrin and 45 mg of betacyclodextrin as a coating material. 235 mg is prepared.
(단계 2) 발포제 조성물의 제조 (Step 2) Preparation of the Foaming Agent Composition
단계 1에서 제조된 235 mg의 혼합 기재에 230 mg의 탄산수소나트륨 발포제, 60 mg의 경질무수규산과 30 mg의 무수인산수소칼슘의 연마제, 70 mg의 구연산, 1 mg의 라우릴황산나트륨, 8 mg의 크로스포비돈 붕해제에 적량의 감미제, 향료, 활택제를 첨가하여 총 중량 1000 mg의 발포제 조성물을 제조한다. On the 235 mg mixed substrate prepared in step 1, 230 mg of sodium bicarbonate blowing agent, 60 mg of hard silicic anhydride and 30 mg of anhydrous calcium hydrogen phosphate abrasive, 70 mg of citric acid, 1 mg of sodium lauryl sulfate, 8 mg An appropriate amount of sweetener, flavoring agent, and lubricant is added to the crospovidone disintegrant in to prepare a foaming agent composition having a total weight of 1000 mg.
(단계 3) 구강 세정용 발포정의 제조 (Step 3) Preparation of the foam tablet for oral cleaning
단계 2에서 제조된 발포제 조성물을 혼합시키고 정립시킨 후 타정시켜 구강 세정용 발포정을 제조한다. The blowing agent composition prepared in step 2 is mixed, stipulated, and compressed to prepare a foam for oral cleaning.
(제조비교예 1) 구강 세정용 발포정의 제조 (미세결정 셀룰로오스 단일성분 발포 기재)Preparation Example 1 Preparation of Foam for Oral Washing (Microcrystalline Cellulose Monocomponent Foam Base)
(단계 1) 기재의 제조(Step 1) Preparation of Substrate
235 mg의 미세결정 셀룰로오스를 발포 기재로 준비한다. 235 mg of microcrystalline cellulose is prepared as foam substrate.
(단계 2) 발포제 조성물의 제조 (Step 2) Preparation of the Foaming Agent Composition
단계 1에서 제조된 235 mg의 미세결정 셀룰로오스 기재에 230 mg의 탄산수소나트륨 발포제, 60 mg의 경질무수규산과 30 mg의 무수인산수소칼슘의 연마제, 70 mg의 구연산, 1 mg의 라우릴황산나트륨, 8 mg의 크로스포비돈 붕해제에 적량의 감미제, 향료, 활택제를 첨가하여 총 중량 1000 mg의 발포제 조성물을 제조한다. On the 235 mg microcrystalline cellulose substrate prepared in step 1, 230 mg of sodium bicarbonate blowing agent, 60 mg of hard silicic anhydride and 30 mg of anhydrous calcium hydrogen phosphate, 70 mg of citric acid, 1 mg of sodium lauryl sulfate, An appropriate amount of sweetener, fragrance, glidant is added to 8 mg crospovidone disintegrant to prepare a total weight of 1000 mg blowing agent composition.
(단계 3) 구강 세정용 발포정의 제조 (Step 3) Preparation of the foam tablet for oral cleaning
단계 2에서 제조된 발포제 조성물을 혼합시키고 정립시킨 후 타정시켜 구강 세정용 발포정을 제조한다. The blowing agent composition prepared in step 2 is mixed, stipulated, and compressed to prepare a foam for oral cleaning.
(제조비교예 2) 구강 세정용 발포정의 제조 (라우릴황산나트륨 및 크로스포비돈 미첨가)Preparation Example 2 Preparation of Foam for Oral Washing (No Sodium Lauryl Sulfate and Crospovidone Added)
(단계 1) 혼합 기재의 제조(Step 1) Preparation of Mixed Substrate
80 mg의 미세결정 셀룰로오스를 코어 물질로 하고 110 mg의 말토덱스트린 및 45 mg의 베타시클로덱스트린을 코팅 물질로 하여 미세결정 셀룰로오스에 말토덱스트린과 베타시클로덱스트린을 코팅기 내에서 흡식 혼합법으로 분산시켜 혼합 기재 235 mg을 제조한다. A mixed substrate was prepared by dispersing maltodextrin and betacyclodextrin in a coating machine by suction mixing method using 80 mg of microcrystalline cellulose as a core material and 110 mg of maltodextrin and 45 mg of betacyclodextrin as a coating material. 235 mg is prepared.
(단계 2) 발포제 조성물의 제조 (Step 2) Preparation of the Foaming Agent Composition
단계 1에서 제조된 235 mg의 혼합 기재에 230 mg의 탄산수소나트륨 발포제, 60 mg의 경질무수규산과 30 mg의 무수인산수소칼슘의 연마제, 79 mg의 구연산에 적량의 감미제, 향료, 활택제를 첨가하여 총 중량 1000 mg의 발포제 조성물을 제조한다. 235 mg of the mixed substrate prepared in step 1 was prepared with 230 mg of sodium bicarbonate blowing agent, 60 mg of hard silicic anhydride and 30 mg of anhydrous calcium hydrogen phosphate, 79 mg of citric acid, and an appropriate amount of sweetener, flavoring, glidant. Add to prepare a blowing agent composition with a total weight of 1000 mg.
(단계 3) 구강 세정용 발포정의 제조 (Step 3) Preparation of the foam tablet for oral cleaning
단계 2에서 제조된 발포제 조성물을 혼합시키고 정립시킨 후 타정시켜 구강 세정용 발포정을 제조한다. The blowing agent composition prepared in step 2 is mixed, stipulated, and compressed to prepare a foam for oral cleaning.
(실시예 1) 발포성 시험Example 1 Foamability Test
제조실시예 내의 단계 2에서 제조된 구강 세정용 발포제 조성물 1 g과 제조비교예 1에서 제조된 구강 세정용 발포제 조성물 1 g, 제조비교예 2에서 제조된 구강 세정용 발포제 조성물 1 g 등 3 종의 시료를 사용하였다. 시료 각각 1 g을 10 ml의 인공 타액(50 mM KCl, 1 mM KH2PO4, 1 mM CaCl2, 0.1 mM MgCl2) 내에 투입하고 시료와 인공 타액의 혼합액을 200 rpm으로 교반하면서 발포시켜 최대 10분간 인공 타액 내의 발포된 시료의 용출을 측정하였다. 그 결과를 표 1에 나타내었다. Three kinds of the oral cleansing foam composition prepared in step 2 in the preparation example 1 and the oral cleansing foam composition prepared in Comparative Example 1 1g, 1 g of the oral cleansing foam composition prepared in Comparative Example 2 Samples were used. 1 g of each sample is placed in 10 ml of artificial saliva (50 mM KCl, 1 mM KH 2 PO 4, 1 mM CaCl 2 , 0.1 mM MgCl 2 ), and the mixture of the sample and the artificial saliva is foamed while stirring at 200 rpm. The elution of the foamed sample in artificial saliva was measured for a minute. The results are shown in Table 1.
표 1에 나타난 바와 같이 본 발명의 제조실시예에서 제조된 구강 세정용 발포제 조성물의 경우 타액에서 3분 이상 발포 용출시 제조비교예 1, 2에서 제조된 발포제 조성물보다 높은 발포 용출 속도를 나타내었다. 이를 통해 본 발명의 말토덱스트린 및 베타시클로덱스트린 코팅 미세결정 셀룰로오스 혼합 기재가 타액 내에서 3분 이상의 일정 기간 경과 후 제조비교예 1, 2에서 제조된 발포제 조성물보다 더욱 높게 발포 용출됨을 의미하는 것이다. As shown in Table 1, the foaming agent composition for oral cleansing prepared in the preparation example of the present invention exhibited a higher foaming dissolution rate than the foaming agent compositions prepared in Comparative Examples 1 and 2 when foamed and eluted in saliva for at least 3 minutes. This means that the maltodextrin and betacyclodextrin-coated microcrystalline cellulose mixed substrate of the present invention is foamed and eluted higher than the foaming agent composition prepared in Comparative Examples 1 and 2 after a predetermined period of 3 minutes or more in saliva.
다만 3분 이내의 발포 용출시에는 본 발명의 구강 세정용 발포제 조성물과 제조비교예 1, 2에서 제조된 발포제 조성물 간의 유의미한 발포 용출 속도의 차이는 나타나지 않았다. However, when the foam dissolution was within 3 minutes, there was no significant difference in the foam dissolution rate between the foaming agent composition for oral cleaning of the present invention and the foaming agent compositions prepared in Comparative Examples 1 and 2.
(실시예 2) 조직감 및 발포 안정성 시험 Example 2 Texture and Foaming Stability Test
제조실시예에서 제조된 구강 세정용 발포정 100정과 제조비교예 1 및 2에서 제조된 구강 세정용 발포정 각각 100정 등 총 300정의 발포정을 사용하여 조직감 및 구강 내 발포 정도에 따른 발포정의 발포 안정성을 시험하였다. 20인의 패널을 대상으로 교차 시험을 통해 구강 세정용 발포정의 조직감 및 발포 안정성을 측정하였다. 그 결과를 표 2에 나타내었다. Foaming of the foamed tablet according to texture and oral foaming degree using a total of 300 foamed tablets, including 100 tablets for oral cleansing tablets prepared in Examples and 100 tablets for oral cleansing prepared in Comparative Examples 1 and 2, respectively. Stability was tested. Tissues and foaming stability of the foam tablets for oral lavage were measured in a cross test of 20 panelists. The results are shown in Table 2.
(조직감 및 발포 안정성의 판정 기준)(Judgement criteria of texture and foam stability)
평점 1 : 조직감 및 발포 안정성이 매우 불량하여 거부감이 매우 심함Rating 1: Very poor rejection due to poor texture and foam stability
평점 2 : 조직감 및 발포 안정성이 불량하여 거부감이 있음Rating 2: Rejection due to poor texture and foam stability
평점 3 : 조직감 및 발포 안정성이 보통이며 거부감은 없음Rating 3: Normal texture and foam stability with no rejection
평점 4 : 조직감 및 발포 안정성이 양호하여 거부감은 없음Rating 4: Good texture and foam stability, no rejection
평점 5 : 조직감 및 발포 안정성이 매우 양호하여 거부감은 없음Rating 5: Very good texture and foam stability, no rejection
표 2에 나타난 바와 같이 본 발명의 구강 세정용 발포정의 경우 조직감 및 발포 안정성이 우수하게 나타남을 확인할 수 있었다. 특히 본 발명의 구강 세정용 발포정의 경우 말토덱스트린 및 베타시클로덱스트린을 코팅시킨 미세결정 셀룰로오스 혼합 기재를 사용함으로써 혼합 기재를 사용하지 않은 제조비교예 1 또는 라우릴황산나트륨 및 크로스포비돈을 사용하지 않은 제조비교예 2의 발포정 보다 조직감 및 발포 안정성이 개선된 것으로 판단된다.As shown in Table 2, the foam tablet for oral cleaning of the present invention was confirmed that the texture and foam stability was excellent. In particular, in the case of effervescent tablets for oral cleaning of the present invention, by using maltodextrin and beta cyclodextrin coated microcrystalline cellulose mixed substrate Comparative Preparation Example 1 without using a mixed substrate or Comparative Preparation without using sodium lauryl sulfate and crospovidone The texture and foaming stability of the foamed tablets of Example 2 are believed to be improved.
(실시예 3) 구강 세정 효과 시험 Example 3 Oral Washing Effect Test
제조실시예에서 제조된 구강 세정용 발포정 50정과 제조비교예 1 및 2에서 제조된 구강 세정용 발포정 각각 50정 등 총 150정의 발포정을 사용하여 구강 세정 효과를 시험하였다. 10인의 패널을 대상으로 교차 시험을 통해 구강 세정용 발포정의 구강 세정 효과를 측정하였다. 그 결과를 표 3에 나타내었다. The oral lavage effect was tested using a total of 150 effervescent tablets, including 50 tablets for oral cleansing prepared in the preparation examples and 50 tablets for oral cleansing prepared in Comparative Examples 1 and 2, respectively. The oral cleansing effect of the foam tablet for oral lavage was measured through a crossover test on 10 panelists. The results are shown in Table 3.
(구강 세정 효과 판정 기준)(Oral cleaning effect judgment standard)
평점 1 : 구강 세정 효과가 매우 불량하여 구취가 매우 심함Rating 1: Bad oral cleaning effect, very bad breath
평점 2 : 구강 세정 효과가 불량하여 구취가 있음Rating 2: Poor breath due to poor oral cleaning effect
평점 3 : 구강 세정 효과가 보통이며 구취는 약함Rating 3: Oral cleansing effect is moderate, bad breath is weak
평점 4 : 구강 세정 효과가 양호하여 구취는 없음Rating 4: No bad breath due to good oral cleaning effect
평점 5 : 구강 세정 효과가 매우 양호하여 약한 향내가 느껴짐Rating 5: Very good oral cleansing effect with a mild fragrance
표 3에 나타난 바와 같이 본 발명의 구강 세정용 발포정의 경우 구강 세정 효과가 우수하게 나타남을 확인할 수 있었다. 특히 본 발명의 구강 세정용 발포정의 경우 말토덱스트린 및 베타시클로덱스트린을 코팅시킨 미세결정 셀룰로오스 혼합 기재를 사용함으로써 타액 내 연마제 및 유기산의 분산을 용이하게 할 뿐만 아니라 향료 및 감미료의 분산 역시 용이하게 함으로써 혼합 기재를 사용하지 않은 제조비교예 1 또는 라우릴황산나트륨 및 크로스포비돈을 사용하지 않은 제조비교예 2의 발포정 보다 구강 세정 효과가 개선된 것으로 판단된다.As shown in Table 3, in the case of the foam tablet for oral cleaning of the present invention was confirmed that the oral cleaning effect is excellent. In particular, in the case of effervescent tablets for oral cleaning of the present invention, by using a microcrystalline cellulose mixed substrate coated with maltodextrin and betacyclodextrin, not only facilitates dispersion of abrasives and organic acids in saliva, but also facilitates dispersion of flavors and sweeteners. It is believed that the oral cleaning effect is improved compared to the foaming tablets of Preparation Comparative Example 1 without using a base material or Preparation Comparative Example 2 without using sodium lauryl sulfate and crospovidone.
Claims (5)
ⅱ) 20 ~ 25 중량%의 탄산수소나트륨 발포제;
ⅲ) 5 ~ 15 중량%의 경질무수규산 또는 무수인산수소칼슘에서 선택된 1종 이상의 연마제;
ⅳ) 5 ~ 10 중량%의 구연산;
ⅴ) 0.05 ~ 0.5 중량%의 라우릴황산나트륨 기포제;
ⅵ) 0.1 ~ 1.0 중량%의 크로스포비돈 붕해제; 및
ⅶ) 0.05 ~ 0.5 중량%의 불소계 충치 예방제;
를 포함하는 발포성 및 안정성이 향상된 구강 세정용 발포정에 있어서,
상기 발포 기재는 미세결정 셀룰로오스 코어 물질에 말토덱스트린 및 베타시클로덱스트린을 코팅시킨 혼합 발포 기재이며, 상기 발포 기재의 발포성과 안정성을 향상시키기 위해 발포정 내의 발포 기재의 함량을 35 중량% 이하로 감소시킨 발포성 및 안정성이 향상된 구강 세정용 발포정.
Iii) 20 to 35% by weight of foamed substrate;
Ii) 20 to 25% by weight sodium hydrogen carbonate blowing agent;
Iii) at least one abrasive selected from 5 to 15% by weight of hard silicic anhydride or anhydrous calcium hydrogen phosphate;
Iii) 5 to 10 weight percent citric acid;
Iii) 0.05-0.5% by weight sodium lauryl sulfate foaming agent;
Viii) 0.1-1.0 wt% crospovidone disintegrant; And
Iii) 0.05 to 0.5% by weight of fluorine-based tooth decay preventive agents;
In the foam and oral cleaning foam improved stability including,
The foamed base material is a mixed foamed base material coated with maltodextrin and betacyclodextrin on a microcrystalline cellulose core material. Foam for oral cleaning with improved foamability and stability.
According to claim 1, wherein the foam base is foamed and characterized in that it is prepared by coating 8 to 14% by weight of maltodextrin and 3 to 6% by weight of betacyclodextrin to 7 to 12% by weight of the microcrystalline cellulose core material Foam for oral cleaning with improved stability.
The viscosity of the 1.0 wt% aqueous solution of maltodextrin and betacyclodextrin-coated microcrystalline cellulose, which are the foamed substrates, is 20 to 70 mPa · s when measured at a 20 rpm / min rotational speed with a Brookfield rotary viscometer. Effervescent tablet for oral cleaning.
The method of claim 1, wherein the citric acid and sodium bicarbonate blowing agent foams carbon dioxide gas through an acid base reaction, and sodium lauryl sulfate, an anionic surfactant, creates bubbles together with saliva and water to improve the oral cleaning power, and the cross Povidone disintegrant is a foam for oral cleaning, characterized in that to promote the disintegration of the foam base material to improve the foamability and stability.
(a) 스테아르산 마그네슘 활택제;
(b) D-만니톨 발포성 강화제;
(c) 오렌지향, 딸기향, 포도향, 페퍼민트오일, 스피아민트오일, 멘톨, 카르본, 아네롤, 오이게놀, 윈터그린, 세이지 또는 유칼립토오일에서 선택된 1종 이상의 향료;
(d) 락토오스, 말토오스, 락티톨, 사카린나트륨, 아스파탐, 스테비오사이드 또는 감초산에서 선택된 1종 이상의 감미료; 또는
(e) 세이지, 로즈마리, 녹차, 감추출물 또는 샨피니온추출물에서 선택된 1종 이상의 구취제거제;
에서 선택된 1종 이상의 첨가제를 더욱 포함함을 특징으로 하는 구강 세정용 발포정.The method according to any one of claims 1 to 4,
(a) magnesium stearate lubricant;
(b) D-mannitol foam enhancer;
(c) at least one flavor selected from orange, strawberry, grape, peppermint oil, spearmint oil, menthol, carbon, anerol, eugenol, wintergreen, sage or eucalypto oil;
(d) at least one sweetener selected from lactose, maltose, lactitol, sodium saccharin, aspartame, stevioside or licoriceic acid; or
(e) at least one deodorant selected from sage, rosemary, green tea, persimmon extract or shanpinion extract;
Foam tablet for oral cleaning, characterized in that it further comprises one or more additives selected from.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2025026931A1 (en) * | 2023-08-03 | 2025-02-06 | Unilever Ip Holdings B.V. | A personal cleansing tablet |
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