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KR102291355B1 - Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법 - Google Patents

Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법 Download PDF

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KR102291355B1
KR102291355B1 KR1020157014102A KR20157014102A KR102291355B1 KR 102291355 B1 KR102291355 B1 KR 102291355B1 KR 1020157014102 A KR1020157014102 A KR 1020157014102A KR 20157014102 A KR20157014102 A KR 20157014102A KR 102291355 B1 KR102291355 B1 KR 102291355B1
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안톤 벨로우소브
지암파올로 비안치니
루카 지안니
마를레네 토마스
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Abstract

본 발명은 환자가 PD-L1 억제제 공동치료가 필요한지를 결정하기 위한 수단 및 방법에 관한 것이다. 환자는, 환자의 샘플에서, 낮거나 부재하는 ER 발현 수준, 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 시험관내에서 측정되는 경우, PD-L1 억제제 공동치료를 필요로 하는 것으로 결정된다. 상기 환자는 HER2/neu(ErbB2) 신호전달 경로의 조절제(예를 들면, 트라스투주맙) 및 화학치료제(예를 들면, 도데탁셀)를 포함하는 치료를 받고 있거나, 또는 상기 치료가 환자에게 고려된다. 본원에는 또한 HER2/neu(ErbB2) 신호전달 경로의 조절제(예를 들면, 트라스투주맙) 및 화학치료제(예를 들면, 도데탁셀)를 포함하는 치료가 고려되는 암 환자에서 암을 치료하기 위한 수단 및 방법이 제공되며, 이때 상기 환자는 PD-L1 억제제 공동치료를 받게 된다.

Description

PD-L1 억제제 공동치료를 필요로 하는 환자의 식별방법{IDENTIFICATION OF PATIENTS IN NEED OF PD-L1 INHIBITOR COTHERAPY}
본 발명은 환자가 PD-L1 억제제 공동치료가 필요한지를 결정하기 위한 수단 및 방법에 관한 것이다. 환자는, 환자의 샘플에서, 낮거나 부재하는 ER 발현 수준, 및 대조군에 비해 증가된 예정 사멸 리간드 1(programmed death ligand 1, PD-L1)의 발현 수준이 시험관내에서 측정되는 경우, PD-L1 억제제 공동치료를 필요로 하는 것으로 결정된다. 상기 환자는 HER2/neu(ErbB2) 신호전달 경로의 조절제(예를 들면, 트라스투주맙(Trastuzumab)) 및 화학치료제(예를 들면, 도데탁셀)를 포함하는 치료를 받고 있거나, 또는 상기 치료가 환자에게 고려된다. 본원에는 또한 HER2/neu(ErbB2) 신호전달 경로의 조절제(예를 들면, 트라스투주맙) 및 화학치료제(예를 들면, 도데탁셀)를 포함하는 치료가 고려되는 암 환자에서 암을 치료하기 위한 수단 및 방법이 제공되며, 이때 상기 환자는 PD-L1 억제제 공동치료를 받게 된다.
수용체 티로신 키나제의 HER 계열은 세포 성장, 분화 및 생존의 중요한 매개체이다. 상기 수용체 계열은 표피 성장 인자 수용체(EGFR, ErbB1 또는 HER1), HER2(ErbB2 또는 p185 neu ), HER3(ErbB3) 및 HER4(ErbB4 또는 tyro2)를 포함한 4개의 별개의 구성원들을 포함한다.
erbB1 유전자에 의해 암호화되는 EGFR은 인간 악성종양에 원인적으로 관련되었다. 특히, EGFR의 증가된 발현이 유방암, 방광암, 폐암, 두부암, 경부암 및 위암뿐 아니라, 교모세포종에서 관찰되었다. 증가된 EGFR 수용체 발현은 흔히, 자가분비 자극 경로에 의한 수용체 활성화를 야기하는 동일한 종양 세포에 의해, EGFR 리간드, 형질전환 성장 인자 알파(TGF-α)의 증가된 생성과 관련된다[Baselga and Mendelsohn Pharmac . Ther. 64:127-154 (1994)]. EGFR 또는 그의 리간드, TGF-α 및 EGF에 대해 유도된 단클론성 항체가 상기 악성종양의 치료에 치료제로서 평가되었다(예를 들면, 문헌 [Baselga and Mendelsohn Pharmac . Ther. 64:127-154 (1994); Masui et al . Cancer Research 44:1002-1007 (1984); and Wu et al . J. Clin. Invest. 95:1897-1905 (1995)] 참조).
HER 계열의 두번째 구성원인 p185 neu 는 원래 화학적으로 처리된 래트의 신경모세포종으로부터 형질전환 유전자의 산물로서 확인되었다. neu 원발암유전자의 활성화 형태는 암호화된 단백질의 막관통 영역에서의 점 돌연변이(발린이 글루탐산으로)로부터 야기된다. neu의 인간 동족체의 증폭이 유방암 및 난소암에서 관찰되며, 불량한 예후와 상관된다(문헌 [Slamon et al ., Science, 235:177-182 (1987); Slamon et al ., Science, 244:707-712 (1989)] 및 미국 특허 제 4,968,603 호). 지금까지, 인간 종양에 대해 neu 원발암유전자에서 상기와 유사한 점 돌연변이는 보고된 바가 없었다. HER2의 과발현(흔히, 그러나 일률적이진 않게 유전자 증폭으로 인해)은 또한 위, 자궁내막, 침샘, 폐, 신장, 결장, 갑상선, 췌장 및 방광의 암종을 포함하여 다른 암종에서도 관찰되었다(특히, 문헌 [King et al ., Science, 229:974 (1985); Yokota et al ., Lancet: 1:765-767 (1986); Fukushige et al ., Mol Cell Biol ., 6:955-958 (1986); Guerin et al ., Oncogene Res ., 3:21-31 (1988); Cohen et al ., Oncogene, 4:81-88 (1989); Yonemura et al ., Cancer Res ., 51:1034 (1991); Borst et al ., Gynecol . Oncol ., 38:364 (1990); Weiner et al ., Cancer Res ., 50:421-425 (1990); Kern et al ., Cancer Res ., 50:5184 (1990); Park et al ., Cancer Res ., 49:6605 (1989); Zhau et al ., Mol . Carcinog ., 3:254-257 (1990); Aasland et al . Br . J. Cancer 57:358-363 (1988); Williams et al . Pathobiology 59:46-52 (1991); and McCann et al ., Cancer, 65:88-92 (1990)] 참조. HER2는 전립선암에서도 과발현될 수 있다Gu et al. Cancer Lett. 99:185-9 (1996); Ross et al . Hum . Pathol. 28:827-33 (1997); Ross et al . Cancer 79:2162-70 (1997); and Sadasivan et al . J. Urol . 150:126-31 (1993))].
래트 p185 neu 및 인간 HER2 단백질 생성물에 대해 유도된 항체가 기술되었다. 드레빈(Drebin)과 동료들은 래트 neu 유전자 산물인 p185 neu 에 대한 항체를 생성하였다(예를 들면, 문헌 [Drebin et al ., Cell 41:695-706 (1985); Myers et al ., Meth. Enzym . 198:277-290 (1991)] 및 WO94/22478 호 참조). 문헌 [Drebin et al . Oncogene 2:273-277 (1988)]은 p185 neu 의 2개의 별개 영역과 반응하는 항체들의 혼합물이 누드 마우스에 이식된 neu-형질전환된 NIH-3T3 세포에 상승적 항-종양 효과를 제공함을 보고하고 있다(또한, 1998년 10월 20일에 허여된 미국 특허 제 5,824,311 호 참조).
문헌 [Hudziak et al ., Mol . Cell . Biol . 9(3):1165-1172 (1989)]은 인간 유방종양 세포주 SK-BR-3을 사용하여 특성화된 HER2 항체 패널의 생성을 기술하고 있다. 항체에 노출후 SK-BR-3 세포의 상대적 세포 증식을 72 시간후 단층의 크리스탈 바이올렛 염색에 의해 측정하였다. 상기 분석을 이용하여, 세포 증식을 56% 억제한 4D5로 지칭된 항체에 의해 최대 억제가 달성되었다. 패널내 다른 항체들은 상기 분석에서 세포 증식을 보다 적게 감소시켰다. 항체 4D5는 또한 HER2-과발현 유방 종양 세포주를 TNF-α의 세포독성 효과에 대해 감작시키는 것으로 밝혀졌다(또한, 1997년 10월 14일에 허여된 미국 특허 제 5,677,171 호 참조). 상기 헛지악(Hudziak) 등의 문헌에 기술된 HER2 항체는 다음 문헌들에 더 특성화되어 있다: [Fendly et al . Cancer Research 50:1550-1558 (1990); Kotts et al . In Vitro 26(3):59a (1990); Sarup et al . Growth Regulation 1:72-82 (1991); Shepard et al . J. Clin . Immunol . 11(3):117-127 (1991); Kumar et al . Mol. Cell . Biol . 11(2):979-986 (1991); Lewis et al . Cancer Immunol . Immunother . 37:255-263 (1993); Pietras et al . Oncogene 9:1829-1838 (1994); Vitetta et al . Cancer Research 54:5301-5309 (1994); Sliwkowski et al . J. Biol . Chem . 269(20):14661-14665 (1994); Scott et al . J. Biol . Chem . 266:14300-5 (1991); D'souza et al . Proc. Natl . Acad . Sci. 91:7202-7206 (1994); Lewis et al . Cancer Research 56:1457-1465 (1996); and Schaefer et al . Oncogene 15:1385-1394 (1997)].
뮤린 HER2 항체 4D5의 재조합 인간화 버전(huMAb4D5-8, rhuMAb HER2, 트라스투주맙 또는 허셉틴(Herceptin, 등록상표); 미국 특허 제 5,821,337 호)은 광범위한 사전 항암 치료를 받았던, HER2-과발현 전이성 유방암을 갖는 환자에서 임상적으로 활성이다[Baselga et al ., J. Clin . Oncol . 14:737-744 (1996)]. 투라스투주맙은 종양이 HER2 단백질을 과발현하는 전이성 유방암을 갖는 환자의 치료를 위해 1998년 9월 25일 식품 의약품국으로부터 판매 승인을 받았다.
인간화 항-ErbB2 항체로는 특별히 본원에 참고로 인용된 미국 특허 제 5,821,337 호의 표 3에 기술된 바와 같은 huMAb4D5-1, huMAb4D5-2, huMAb4D5-3, huMAb4D5-4, huMAb4D5-5, huMAb4D5-6, huMAb4D5-7 및 huMAb4D5-8(허셉틴(등록상표); 인간화 520C9(WO 93/21319 호) 및 특별히 본원에 참고로 인용된 WO 01/000245 호에 기술된 바와 같은 인간화 2C4 항체가 포함된다.
퍼투주맙(Pertuzumab)(예를 들면, WO 01/000245 호 참조)은 HER 이량체화 억제제(HDI)로서 알려진 새로운 부류의 약제의 첫번째 약제이다. 퍼투주맙은 그의 이량체화 도메인에서 HER2에 결합함으로써, 활성 이량체 수용체 복합체를 형성하는 그의 능력을 억제하고 따라서 결국 세포 성장 및 분열을 야기하는 하류 신호 전달계를 차단한다(문헌 [Franklin, M.C., Cancer Cell 5 (2004) 317-328] 참조). 퍼투주맙은 HER2의 세포외 도메인에 대해 유도된 완전 인간화 재조합 단클론성 항체이다. 인간 상피 세포 상에서 HER2에 대한 퍼투주맙의 결합은 HER2가 HER 계열의 다른 구성원(EGFR, HER3, HER4 포함)과의 복합체를 형성하는 것 및 아마도 또한 HER2 호모이량체화(homodimerization)를 방지한다. 복합체 형성을 차단함으로써, 퍼투주맙은 HER1, HER3 및 HER4의 리간드(예를 들면, EGF, TGF알파, 암피레귤린 및 헤레귤린)에 의해 활성화된 성장 자극 효과 및 세포 생존 신호를 방지한다. 퍼투주맙에 대한 또 다른 명칭은 2C4이다. 퍼투주맙은 인간 IgG1(K) 프레임워크 서열을 기반으로 하는 완전 인간화 재조합 단클론성 항체이다. 퍼투주맙의 구조는 2개의 중쇄(449개 잔기) 및 2개의 경쇄(214개 잔기)로 이루어진다. 트라스투주맙(허셉틴(등록상표))과 비교하여, 퍼투주맙은 경쇄에서 12개 아미노산 차이 및 IgG1 중쇄에서 29개 아미노산 차이를 갖는다.
다양한 성질을 갖는 다른 HER2 항체들이 문헌 [Tagliabue et al . Int . J. Cancer 47:933-937 (1991); McKenzie et al . Oncogene 4:543-548 (1989); Maier et al . Cancer Res. 51:5361-5369 (1991); Bacus et al . Molecular Carcinogenesis 3:350-362 (1990); Stancovski et al . PNAS ( USA ) 88:8691-8695 (1991); Bacus et al . Cancer Research 52:2580-2589 (1992); Xu et al . Int . J. Cancer 53:401-408 (1993); WO94/00136; Kasprzyk et al . Cancer Research 52:2771-2776 (1992);Hancock et al . Cancer Res. 51:4575-4580 (1991); Shawver et al . Cancer Res. 54:1367-1373 (1994); Arteaga et al . Cancer Res . 54:3758-3765 (1994); Harwerth et al . J. Biol . Chem. 267:15160-15167 (1992)]; 미국 특허 제 5,783,186 호; 및 문헌 [Klapper et al . Oncogene 14:2099-2109 (1997)]에 기술되었다.
상동성 스크리닝은 2개의 다른 HER 수용체 계열 구성원; HER3(미국 특허 제5,183,884 및 5,480,968 호, 및 문헌 [Kraus et al . PNAS ( USA ) 86:9193-9197 (1989)]) 및 HER4(EP 특허출원 제 599,274 호; 문헌 [Plowman et al ., Proc . Natl . Acad. Sci . USA, 90:1746-1750 (1993); and Plowman et al ., Nature, 366:473-475 (1993)])의 확인을 달성하였다. 상기 수용체 둘 다 적어도 일부의 유방암 세포주 상에서 증가된 발현을 나타낸다.
HER 수용체는 일반적으로 세포에서 다양한 조합으로 발견되며, 헤테로이량체화(heterodimerization)는 다양한 HER 리간드에 대한 세포 반응의 다양성을 증가시키는 것으로 생각된다[Earp et al . Breast Cancer Research and Treatment 35: 115-132 (1995)]. EGFR은 6개의 상이한 리간드; 상피 성장 인자(EGF), 형질전환 성장 인자 알파(TGF-α), 암피레귤린, 헤파린 결합 상피 성장 인자(HB-EGF), 베타셀룰린 및 에피레귤린에 의해 결합된다[Groenen et al . Growth Factors 11:235-257 (1994)]. 단일 유전자의 선택적 스플라이싱으로부터 야기되는 헤레귤린 단백질의 한 계열은 HER3 및 HER4에 대한 리간드이다. 헤레귤린 계열은 알파, 베타 및 감마 헤레귤린([Holmes et al ., Science, 256:1205-1210 (1992)]; 미국 특허 제 5,641,869 호; 및 [Schaefer et al . Oncogene 15:1385-1394 (1997)]); neu 분화 인자(NDF), 신경교 성장 인자(GGF); 활성을 유도하는 아세틸콜린 수용체(ARIA); 및 감각 및 운동 뉴런 유도 인자(SMDF)를 포함한다. 검토를 위해서는, 문헌 [Groenen et al. Growth Factors 11:235-257 (1994); Lemke, G. Molec . & Cell . Neurosci. 7:247-262 (1996) and Lee et al. Pharm . Rev . 47:51-85 (1995)]을 참조하시오). 최근에 3개의 또 다른 HER 리간드가 확인되었다; HER3 또는 HER4에 결합하는 것으로 보고된 뉴레귤린-2(NRG-2)[Chang et al . Nature 387 509-512 (1997); and Carraway et al Nature 387:512-516 (1997)]; HER4에 결합하는 뉴레귤린-3[Zhang et al . PNAS (USA) 94(18):9562-7 (1997)]; 및 HER4에 결합하는 뉴레귤린-4[Harari et al . Oncogene 18:2681-89 (1999)]. HB-EGF, 베타셀룰린 및 에피레귤린도 또한 HER4에 결합한다.
EGF 및 TGFα는 HER2에 결합하지 않지만, EGF는 EGFR 및 HER2를 자극하여 헤테로이량체를 형성하고, 이것은 EGFR을 활성화시키고 헤테로이량체에서 HER2의 트랜스포스포릴화를 야기한다. 이량체화 및/또는 트랜스포스포릴화는 HER2 티로신 키나제를 활성화시키는 것으로 보인다(문헌 [Earp et al ., Breast Cancer Research and Treatment 35: 115-132 (1995)] 참조). 유사하게, HER3이 HER2와 동시발현되는 경우, 활성 신호전달 복합체가 형성되고 HER2에 대해 유도된 항체는 상기 복합체를 파괴할 수 있다[Sliwkowski et al ., J. Biol . Chem., 269(20):14661-14665 (1994)]. 또한, 헤레귤린(HRG)에 대한 HER3의 친화도는 HER2와 동시발현될 때 더 높은 친화도 상태로 증가된다. HER2-HER3 단백질 복합체에 관해서는 또한 문헌 [Levi et al ., Journal of Neuroscience 15: 1329-1340 (1995); Morrissey et al ., Proc . Natl . Acad . Sci . USA 92: 1431-1435 (1995); and Lewis et al ., Cancer Res ., 56:1457-1465 (1996)]을 참조하시오. HER4는, HER3과 마찬가지로, HER2와 활성 신호전달 복합체를 형성한다[Carraway and Cantley, Cell 78:5-8 (1994)].
또한 항체 변이체 조성물이 당해 분야에 기술되어 있다. 미국 특허 제 6,339,142 호는 항-HER2 항체와 그의 하나 이상의 산성 변이체의 혼합물을 포함하는 HER2 항체 조성물을 기술하고 있으며, 상기 혼합물에서 산성 변이체(들)의 양은 약 25% 미만이다. 트라스투주맙이 예시된 HER2 항체이다. 문헌 [Reid et al . Poster presented at Well Characterized Biotech Pharmaceuticals conference (January, 2003) "effects of Cell Culture Process Changes on Humanized Antibody Characteristic"]은 그의 중쇄 상에서 VHS 신호 펩티드, N-말단 글루타민 및 피로글루탐산의 조합으로 인한 N-말단 이종성을 갖는 무명의 인간화 IgG1 항체 조성물을 기술하고 있다. 문헌 [Harris et al . "The Ideal Chromatographic Antibody Characterization Metho" talk presented at the IBC Antibody Production Conference (February, 2002)]은 E25, 인간화 항-IgE 항체의 중쇄 상에서의 VHS 연장을 보고하고 있다. 문헌 [Rouse et al . Poster presented at WCBP "Glycoprotein Characterization by High Resolution Mass Spectrometry and Its Application to Biopharmaceutical Development" (January 6-9, 2004)]은 그의 경쇄상의 AHS 또는 HS 신호 펩티드 잔기로부터 비롯된 N-말단 이종성을 갖는 단클론성 항체 조성물을 기술하고 있다. IBC 회의(2000년 9월)("Strategic Use of Comparability Studies and Assays for Well Characterized Biologicals")에서의 프레젠테이션에서 질 포터(Jill Porter)는 그의 중쇄 상에 3개의 추가 아미노산 잔기를 갖는 제나팍스(ZENAPAX, 등록상표)의 말기-용출 형태를 논의하였다. US 2006/0018899 호는 주요 종인 퍼투주맙 항체 및 아미노-말단 리더 연장 변이체, 및 퍼투주맙 항체의 다른 변이체 형태를 포함하는 조성물을 기술하고 있다.
HER 항체에 관한 특허 공보로는 다음이 포함된다: US 5,677,171, US 5,720,937, US 5,720,954, US 5,725,856, US 5,770,195, US 5,772,997, US 6,165,464, US 6,387,371, US 6,399,063, US 2002/0192211a1, US 6,015,567, US 6,333,169, US 4,968,603, US 5,821,337, US 6,054,297, US 6,407,213, US 6,719,971, US 6,800,738, US 2004/0236078A1, US 5,648,237, US 6,267,958, US 6,685,940, US 6,821,515, WO 98/17797, US 6,127,526, US 6,333,398, US 6,797,814, US 6,339,142, US 6,417,335, US 6,489,447, WO 99/31140, US 2003/0147884a1, US 2003/0170234a1, US 2005/0002928A1, US 6,573,043, US 2003/0152987A1, WO 99/48527, US 2002/0141993a1, WO 01/00245, US 2003/0086924, US 2004/0013667A1, WO 00/69460, WO 01/00238, WO 01/15730, US 6,627,196B1, US 6,632,979b1, WO 01/00244, US 2002/0090662a1, WO 01/89566, US 2002/0064785, US 2003/0134344, WO 04/24866, US 2004/0082047, US 2003/0175845a1, WO 03/087131, US 2003/0228663, WO 2004/008099a2, US 2004/0106161, WO 2004/048525, US 2004/0258685a1, US 5,985,553, US 5,747,261, US 4,935,341, US 5,401,638, US 5,604,107, WO 87/07646, WO 89/10412, WO 91/05264, EP 412,116 B1, EP 494,135 B1, US 5,824,311, EP 444,181 B1, EP 1,006,194 A2, US 2002/0155527A1, WO 91/02062, US 5,571,894, US 5,939,531, EP 502,812 B1, WO 93/03741, EP 554,441 B1, EP 656,367 A1, US 5,288,477, US 5,514,554, US 5,587,458, WO 93/12220, WO 93/16185, US 5,877,305, WO 93/21319, WO 93/21232, US 5,856,089, WO 94/22478, US 5,910,486, US 6,028,059, WO 96/07321, US 5,804,396, US 5,846,749, EP 711,565, WO 96/16673, US 5,783,404, US 5,977,322, US 6,512,097, WO 97/00271, US 6,270,765, US 6,395,272, US 5,837,243, WO 96/40789, US 5,783,186, US 6,458,356, WO 97/20858, WO 97/38731, US 6,214,388, US 5,925,519, WO 98/02463, US 5,922,845, WO 98/18489, WO 98/33914, US 5,994,071, WO 98/45479, US 6,358,682 B1, US 2003/0059790, WO 99/55367, WO 01/20033, US 2002/0076695 A1, WO 00/78347, WO 01/09187, WO 01/21192, WO 01/32155, WO 01/53354, WO 01/56604, WO 01/76630, WO02/05791, WO 02/11677, US 6,582,919, US 2002/0192652a1, US 2003/0211530A1, WO 02/44413, US 2002/0142328, US 6,602,670 B2, WO 02/45653, WO 02/055106, US 2003/0152572, US 2003/0165840, WO 02/087619, WO 03/006509, WO03/012072, WO 03/028638, US 2003/0068318, WO 03/041736, EP 1,357,132, US 2003/0202973, US 2004/0138160, US 5,705,157, US 6,123,939, EP 616,812 B1, US 2003/0103973, US 2003/0108545, US 6,403,630 B1, WO 00/61145, WO 00/61185, US 6,333,348 B1, WO 01/05425, WO 01/64246, US 2003/0022918, US 2002/0051785 A1, US 6,767,541, WO 01/76586, US 2003/0144252, WO 01/87336, US 2002/0031515 A1, WO 01/87334, WO 02/05791, WO 02/09754, US 2003/0157097, US 2002/0076408, WO 02/055106, WO 02/070008, WO 02/089842 및 WO 03/86467.
HER2 항체 트라스투주맙/허셉틴(등록상표)으로 치료된 환자가 HER2 단백질 과발현/유전자 증폭을 기반으로 하는 치료에 선택된다; 예를 들면, WO 99/31140 호 (페이튼 등(Paton et al.)), US 2003/0170234a1 호(헬만(Hellmann, S.)), 및 US 2003/0147884 호(페이튼 등); 및 WO 01/89566 호, US 2002/0064785 호, 및 US 2003/0134344 호(매스 등(Mass et al.)) 참조. 또한, HER2 과발현 및 증폭을 검출하기 위한 면역조직화학(IHC) 및 원위치 형광 하이브리드화(fluorescence in situ hybridization, FISH)에 관한 US 2003/0152987 호(코헨 등(Cohen et al.))를 참조하시오. WO 2004/053497 호 및 US 2004/024815a1 호(바커스 등(Bacus et al.)), 및 US 2003/0190689 호(크로스비 및 스미스(Crosby and Smith))는 트라스투주맙 치료에 대한 반응을 측정하거나 예측하는 것에 관한 것이다. US 2004/013297A1 호(바커스 등)는 ABX0303 EGFR 항체 치료에 대한 반응을 측정하거나 예측하는 것에 관한 것이다. WO 2004/000094 호(바커스 등)는 GW572016, 소분자, EGFR-HER2 티로신 키나제 억제제에 대한 반응을 측정하는 것에 관한 것이다. WO 2004/063709 호(암러 등(Amler et al.))는 EGFR 억제제, 에를로티닙 HCl에 대한 민감성을 측정하기 위한 바이오마커 및 방법에 관한 것이다. US 2004/0209290 호(코블레이 등(Cobleigh et al.))는 유방암 예후에 대한 유전자 발현 마커에 관한 것이다.
HER2 이량체화 억제제(예를 들면, 본원에 상기에서 보다 상세히 기술된 바와 같은 퍼투주맙)로 치료될 환자가 HER 활성화 또는 이량체화를 기반으로 하는 치료에 선택될 수 있다. 퍼투주맙 및 그를 사용한 치료를 위한 환자의 선별에 관한 특허 공보는 다음을 포함한다: WO 01/00245 호(아담스 등(Adams et al.)); US 2003/0086924 호(슬리브코브스키(Sliwkowski, M.)); US 2004/0013667A1 호(슬리브코브스키); 및 WO 2004/008099a2 및 US 2004/0106161 호(보센마이어 등(Bossenmaier et al.)).
허셉틴(등록상표)/트라스투주맙은 당해 분야에서 종양이 HER2 단백질을 과발현하거나 또는 HER2 유전자 증폭을 갖는 전이성 유방암을 갖는 환자의 치료에 권고된다:
a) 그의 전이성 질환에 대해 2가지 이상의 화학치료 요법을 받았던 환자의 치료를 위한 단일치료로서. 사전 화학치료는 환자가 그 치료에 부적합하지 않는 한 적어도 안트라사이클린 및 탁산을 포함하였어야 한다. 호르몬 수용체 양성 환자는 또한 환자가 그 치료에 부적합하지 않는 한 호르몬 치료를 받았어야 한다.
b) 그의 전이성 질환에 대한 화학치료를 받지 않았고 안트라사이클린이 적합하지 않은 환자의 치료를 위해 파클리탁셀과 함께, 및
c) 그의 전이성 질환에 대한 화학치료를 받지 않은 환자의 치료를 위해 도세탁셀과 함께.
허셉틴(등록상표)/트라스투주맙도 또한 초기 유방암에 보조 치료로 사용될 수 있다. 허셉틴(등록상표)/트라스투주맙은 또한 수술, 화학치료(선행보조요법(neoadjuvant)(즉, 수술전) 또는 보조요법(adjuvant)) 및 방사선치료(적용가능한 경우) 후 HER2-양성 초기 유방암을 갖는 환자의 치료에 승인되어 있다. 또한, 카페시타빈 또는 5-플루오로우라실 및 시스플라틴과 함께 허셉틴은 그의 전이성 질환에 대한 사전 항암 치료를 받지 않은 위 또는 위식도 접합부의 HER2 양성 국소 진행성 또는 전이성 선암을 갖는 환자의 치료에 권고된다. 선행보조 퍼투주맙 및 트라스투주맙 치료의 효능 및 안전성은 2상 시험(네오스피어(NEOSPHERE))에서 평가되었다[Gianni (2012) Lancet Oncol 13, 25-32].
당해 분야에서, 허셉틴(등록상표)/트라스투주맙을 사용한 유방암 환자의 치료는, 예를 들면, HER2-양성 암을 갖는 환자에게 권장되며 통상적이다. 면역조직화학 방법에 의해 검출된 높은 HER2 (단백질) 발현 수준(예를 들면, HER2(+++)), 또는 원위치-하이브리드화에 의해 검출된 HER2 유전자 증폭(예를 들면, ISH 양성,예를 들어, 종양 세포 당 HER2 유전자의 4개 복제보다 높은 HER2 유전자 복제수, 또는 HER2 유전자 복제수 대 CEP17에 대한 신호의 수에 대해 ≥2.0의 비), 또는 둘 다가 환자로부터 수득된 샘플, 예를 들면, 유방 조직 생검물 또는 유방 조직 절편에서 또는 전이 부위로부터 수득된 조직에서 발견되는 경우, HER2-양성 암이 존재한다.
WO 2011/109789 호, WO 2011/066342 호, WO 2009/089149 호 및 WO2006/133396 호는 PD-L1 억제제의 치료 용도를 개시하고 있다. 또한, WO 2010/077634 호는 항-PD-L1 항체 및 그의 치료 용도를 개시하고 있다.
본 발명은, 하기 단계를 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법에 관한 것이다:
a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 시험관내에서 측정하는 단계; 및
b) 낮거나 부재하는 ER 발현 수준 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
따라서, 본 발명은, 하기 단계를 포함하는, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제와 함께 PD-L1 조절제 공동치료에 대한 암 환자의 필요를 결정하는 방법을 제공한다:
- HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나 또는 상기 치료를 받고 있는 환자의 종양 샘플을 검사하고;
- 상기 종양 샘플에서 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 측정하되,
이때, 낮거나 부재하는 ER 발현 수준 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준은 상기 환자에서 PD-L1 조절제 공동치료의 성공적인 사용을 나타낸다.
도 1은 HER2 단백질 구조의 도식 및 그의 세포외 도메인의 도메인 I 내지 IV 각각에 대한 아미노산 서열을 나타낸다.
도 2a 및 2b는 뮤린 단클론성 항체 2C4의 가변 경쇄(VL)(도 2a) 및 가변 중쇄(VH)(도 2b) 도메인(각각 서열번호 5 및 6); 변이체 574/퍼투주맙의 VL 및 VH 도메인(각각 서열번호 7 및 8), 및 인간 VL 및 VH 공통 프레임워크(hum κ1, 경쇄 카파 아족 I; humIII, 중쇄 아족 III)(각각 서열번호 9 및 10)의 아미노산 서열들의 정렬을 나타낸 것이다. 별표는 퍼투주맙과 뮤린 단클론성 항체 2C4의 가변 도메인 간의 차이 또는 퍼투주맙과 인간 프레임워크의 가변 도메인 간의 차이를 확인한 것이다. 상보성 결정 영역(Complementarity Determining Region, CDR)은 괄호안에 나타내었다.
도 3a 및 3b는 퍼투주맙 경쇄(도 3a) 및 중쇄(도 3b)의 아미노산 서열을 나타낸 것이다. CDR은 굵은 활자로 나타내었다. 경쇄 및 중쇄의 계산된 분자질량은 23,526.22 Da 및 49,216.56 Da (환원된 형태의 시스테인)이다. 탄수화물 잔기는 중쇄의 Asn 299에 결합된다.
도 4a 및 4b는 각각 트라스투주맙 경쇄(도 4a) 및 중쇄(도 4b)의 아미노산 서열을 나타낸 것이다. 가변 경쇄 및 가변 중쇄 도메인의 경계는 화살표로 나타내었다.
도 5a 및 5b는 각각 변이체 퍼투주맙 경쇄 서열(도 5a) 및 변이체 퍼투주맙 중쇄 서열(도 5b)을 나타낸 것이다.
도 6은 유전자의 마지막 엑손/3'UTR에 상응하는 선택된 프로브 세트를 나타낸 것이다.
도 7은 또한 유전자의 마지막 엑손/3'UTR을 나타내는 프로브 세트이다.
도 8은 ER- 및 ER+ 집단 둘 다의 샘플에서 CD274 및 IFNG 유전자의 발현의 결합 분포를 나타낸 것이다.
도 9a는 pCR ER=ERneg에 의한 CD274 발현의 일원 분석 결과를 나타낸 것이고, 도 9b는 상기 분석의 비등분산을 추정한 결과이다.
도 10a는 pCR ER=ERneg에 의한 IFNG 발현의 일원 분석 결과를 나타낸 것이고, 도 10b는 상기 분석의 비등분산을 추정한 결과이다.
도 11a는 pCR ER=ERpos에 의한 CD274 발현의 일원 분석 결과를 나타낸 것이고, 도 11b는 상기 분석의 비등분산을 추정한 결과이다.
도 12a는 pCR ER=ERpos에 의한 IFNG 발현의 일원 분석 결과를 나타낸 것이고, 도 12b는 상기 분석의 비등분산을 추정한 결과이다.
도 13은 치료수용자의 수술 특성을 나타낸 것이다.
도 14는 리프트 곡선을 나타낸 것이다.
도 15는 유전자 발현 프로파일링의 예측 프로파일러를 나타낸 것이다.
도 16은 치료수용자의 수술 특성을 나타낸 것이다.
도 17은 ER 음성 샘플에서 주 임상 공변량 및 임상 반응의 분포를 나타낸 것이다.
도 18은 ER 양성 샘플에서 주 임상 공변량 및 임상 반응의 분포를 나타낸 것이다.
도 19는 환자가 본 발명에 따른 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정할 수 있게 하는 유전자 발현 분석의 컷-오프 값을 나타낸 것이다.
첨부된 실시예에서 입증되듯이, 놀랍게도, 본 발명에서, 예정 사멸 리간드 1(PD-L1)의 발현 수준이 대조군에 비해 ER 음성(ER(-)) 암 환자의 샘플에서 증가되는 경우, HER2/neu (ErbB2) 신호전달 경로의 조절제(예를 들면, 허셉틴(등록상표)/트라스투주맙) 및 화학치료제(예를 들면, 도데탁셀/탁소테어(Taxotere, 등록상표))를 사용한 치료를 받고 있는 에스트로겐 수용체(ER) 음성(ER(-)) 암 환자(낮거나 심지어 부재하는 ER 발현 수준을 갖는 암 환자)가 에스트로겐 수용체(ER) 양성(ER(+)) 암 환자에 비해 치료에 대해 훨씬 더 나쁜 병리적 완전 반응률(pathological complete response, pCR)을 나타내는 것으로 밝혀졌다. 용어 "예정 사멸 리간드 1", "CD274" 및 "PD-L1"은 본원에서 상호교환적으로 사용된다. 그러므로, 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 ER 음성(ER(-)) 암 환자는 PD-L1 억제제를 사용한 추가의 공동치료로부터 이익을 얻을 것이다. 상기 환자들이 HER2/neu (ErbB2) 신호전달 경로의 조절제(예를 들면, 허셉틴(등록상표)/트라스투주맙) 및 화학치료제(예를 들면, 도데탁셀/탁소테어(등록상표))를 사용한 치료에 더해 PD-L1 억제제를 사용한 공동치료를 받을 경우, 상기 환자군에서 병리적 완전 반응률(pCR)은 증가될 것으로 예상된다. 즉, ER 음성(ER(-)) 암 환자는, 환자로부터의 샘플에서 예정 사멸 리간드 1(PD-L1)의 발현 수준이 대조군에 비해 증가하는 경우, HER2/neu (ErbB2) 신호전달 경로의 조절제(예를 들면, 트라스투주맙) 및 화학치료제(예를 들면, 도데탁셀/탁소테어(등록상표)) 이외에 예정 사멸 리간드 1(PD-L1) 억제제를 투여받게 된다. 하기에서, ER 음성 암 환자 또는 ER 음성 암 환자로부터 수득된 (생물학적/종양) 샘플은 본원에서 "ER(-)"로 나타낸다. 마찬가지로, ER 양성 암 환자 또는 ER 양성 암 환자로부터 수득된 (생물학적/종양) 샘플은 본원에서 "ER(+)"로 나타낸다.
상기에 따라서, 본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 효과량의, HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1) 억제제를 환자에게 투여하는 것을 포함한다. 유사하게, 본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다. 따라서, 본 발명에서는 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)을 포함하는 약학 조성물이 고려된다.
상기에 따라서, PD-L1 억제제 공동치료에 대한 암 환자의 필요를 결정하기 위한 본원에 제공된 방법은 단계 a) 전에, 상기 암 환자로부터 샘플을 수득하는 것이거나 수득하는 것을 포함하는 추가의 단계를 포함할 수 있다. 따라서, 본 발명은, 하기의 단계를 추가로 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법을 제공한다:
a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER)의 발현 수준 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 시험관내에서 측정하는 단계, 및
b) 낮거나 부재하는 ER 발현 수준 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
또한, 환자 샘플에서 예정 사멸 리간드 1(PD-L1)의 발현 수준 이외에 인터페론-감마(IFNγ)의 발현 수준을 측정하는 경우, PD-L1 억제제 공동치료에 대한 환자의 필요를 훨씬 더 신뢰할 수 있게 결정할 수 있음이 본 발명에서 밝혀졌으며, 첨부된 실시예에서 입증된다. 본원에서, 예정 사멸 리간드 1(PD-L1)의 발현 수준이 증가되는 경우 및 인터페론-감마(IFNγ)의 발현 수준이 감소되는 경우, ER 발현이 낮거나 부재하는 환자가 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 사용한 치료에 대해 훨씬 더 나쁜 병리적 완전 반응률을 갖는 것으로 나타난다.
따라서, 본원에 제공된 방법은 바람직하게는, 환자로부터 수득된 샘플에서 인터페론-감마(IFNγ)의 발현 수준을 측정하는 것을 추가로 포함하며, 이때 환자는, 인터페론-감마(IFNγ)의 발현 수준이 대조군에 비해 감소되는 경우 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정된다. 상기에 따라서, 바람직한 양태에서, 본 발명은 하기의 단계를 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법에 관한 것이다:
a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER)의 발현 수준, 예정 사멸 리간드 1(PD-L1)의 발현 수준, 및 인터페론-감마(IFNγ)의 발현 수준을 시험관내에서 측정하는 단계, 및
b) 낮거나 부재하는 ER 발현 수준, 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준, 및 대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
따라서, 대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준은 상기 환자에서 PD-L1 억제제 공동치료의 성공적인 사용을 나타낸다. 상기에 따라서, 본원에 제공된 약학 조성물은 암의 치료에 사용하기 위한 것으로, 이때 상기 암은 낮거나 부재하는 ER 발현 수준을 갖는 것으로 측정되고, 상기 암은 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되며, 상기 암은 대조군에 비해 인터페론-감마(IFNγ)의 감소된 발현 수준을 갖는 것으로 측정된다. 따라서, 낮거나 부재하는 ER 발현 수준을 가지고, 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 가지며, 대조군에 비해 인터페론-감마(IFNγ)의 감소된 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)의 억제제를 포함하는 약학 조성물이 본원에 제공된다.
본원에서 사용된 바와 같은 용어 "암 환자"는 암을 앓고 있는 것으로 추정되거나, 암을 앓고 있거나 또는 암에 걸리기 쉬운 환자를 말한다. 본 발명에 따라 치료될 암은 고형암, 예를 들면, 유방암 또는 위암일 수 있다. 또한, 암은 난소암 또는 대장암일 수 있다. 암은 바람직하게는 "HER2-양성" 암이다.
바람직하게, 암은 유방암, 예를 들어, 초기 유방암이다. 유방암은 초기 단계 유방암 또는 전이성 유방암일 수 있다. 따라서, (치료될) 암 환자는 고형암을 앓고 있는 것으로 추정되거나, 고형 암을 앓고 있거나, 또는 고형 암에 걸리기 쉬우며, 이때 고형암은 유방암 또는 위암일 수 있다. 바람직하게, 암은 유방암, 예를 들어, 초기 단계 유방암이다. 환자는 바람직하게는 인간이다.
상기 언급된 바와 같이, 에스트로겐 수용체(ER), 및 예정 사멸 리간드(PD-L1), 및 선택적으로 인터페론-감마(IFNγ)의 발현 수준은 환자로부터의 샘플에서 시험관내에서 측정될 수 있다. 바람직하게, 본원에 제공된 방법은 환자로부터의 샘플에서 인터페론-감마(IFNγ)를 시험관내에서 측정하는 것을 포함한다. 바람직하게, 여기서 평가/분석될 샘플은 종양 조직 샘플이다. 환자(또는 환자군)은, 낮거나 부재하는 ER 발현 수준 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준 및 선택적으로 대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준이 상기 샘플에서 시험관내에서 측정되는 경우, PD-L1 억제제 공동치료를 필요로 하는 것으로 결정된다.
용어 "ER"은 "에스트로겐 수용체"의 약자이다. 유사하게, 용어 "PD-L1" 및 "IFN-γ"는 각각 용어 "예정 사멸 리간드" 및 "인터페론-감마"의 약자이다. 따라서, 용어 "ER"은 본원에서 "에스트로겐 수용체"와 상호교환적으로 사용될 수 있다. 유사하게, 용어 "PD-L1" 및 "IFN-γ"는 각각 본원에서 용어 "예정 사멸 리간드" 및 "인터페론-감마"와 상호교환적으로 사용될 수 있다.
바람직하게, 치료될 환자 및/또는 암의 (종양/생물학적) 샘플은 낮거나 부재하는 에스트로겐 수용체(ER) 발현 수준에 의해 특성화되거나 또는 그와 관련된다. 바람직하게, 환자의 샘플은 종양 샘플이다. ER 발현 수준은 ER 음성(ER(-))일 수 있다. 용어 "ER(-)"는 본원에서 용어 "ER 음성"과 상호교환적으로 사용될 수 있다.
"ER 음성" 발현 수준은, 예를 들면, [Guideline on Hormone Receptor Testing in Breast Cancer, S. Nofech-Mozes, E. Vella, S. Dhesy-Thind, and W. Hanna (A Quality Initiative of the Program in Evidence-Based Care (PEBC), Cancer Care Ontario (CCO); Report Date: April 8, 2011]에 기술된 바와 같은 통상적인 표준 절차에 의해 측정될 수 있다. 상기 가이드라인(및 그에 인용된 참조문헌들)은 본원에 전체로 참고로 인용된다. 상기 가이드라인은 cancercare.on.ca의 월드 와이드 웹 및 https://www.cancercare.on.ca/toolbox/qualityguidelines/ clin-program/pathlabebs/의 PEBC Pathology & Laboratory Medicine 페이지에서 이용가능하다.
"ER 음성" 발현 수준을 측정하기 위한 통상적인 표준 절차는 상기 가이드라인 및 또한 하기의 참조문헌들에 기술되어 있다:
[Nofech-Mozes S, Vella ET, Dhesy-Thind S, Hagerty KL, Mangu PB, Temin S, et al. Systematic review on hormone receptor testing in breast cancer. Applied Immunohistochem Mol Morphol. 2012 May;20(3):214-63. doi: 10.1097/PAI.0b013e318234aa12. Epub 2011 Nov 11].
[Nofech-Mozes S, Vella ET, Dhesy-Thind S, Hanna WM. Cancer Care Ontario guideline recommendations for hormone receptor testing in breast cancer. Clin Oncol (R Coll Radiol). Epub 2012 May 17].
"ER 음성" 발현은, 예를 들면, ER의 발현 수준이 낮거나 부재하는 경우 및/또는 프로게스테론 수용체(PR) 발현 수준이 낮거나 부재하는 경우, IHC(면역조직화학)에 의해 측정할 수 있다. 약자 "PR"은 본원에서 용어 "프로게스테론 수용체"와 상호교환적으로 사용된다. 샘플 또는 환자는 본원에서 하기의 염색 패턴(IHC에 의한)에 따라 "ER 음성"으로 평가될 수 있다:
핵(세포질은 아님) 염색만 점수를 매겨야 한다.
염색에 대한 3가지 범주가 있다:
양성: ER 또는 PR에 대해 ≥10% 염색
약한 양성: ER 또는 PR에 대해 1% 내지 9% 염색
음성: ER 및 PR에 대해 <1% 염색.
따라서, 샘플 또는 환자는, 샘플이 IHC에 의한 하기의 염색 패턴을 나타내는 경우, 특별히 본원에서 "ER 음성"으로 평가될 수 있다: ER 및 PR에 대해 <1% 염색.
샘플 또는 환자는, 샘플이 IHC에 의해 "양성" 염색: ER 또는 PR에 대해 ≥1% 염색(즉, 검사/평가된 세포의 1%보다 많은 세포가 에스트로겐 수용체 또는 프로게스테론 수용체를 가지고/IHC(면역조직화학)에 의해 에스트로겐 수용체에 대한 염색을 나타낸다)을 나타내는 경우, 본원에서 "ER 양성"으로 평가될 수 있다.
바람직하게, 샘플 또는 환자는, 샘플이 IHC에 의한 하기의 염색 패턴을 나타내는 경우 "ER 음성"으로 평가된다: ER에 대해 <1% 염색(즉, 검사/평가된 세포의 1% 미만이 에스트로겐 수용체를 가지고/IHC(면역조직화학)에 의해 에스트로겐 수용체(들)에 대한 염색을 나타낸다). 가장 바람직하게는, 샘플 또는 환자는, 종양 조직 샘플중의 핵이 IHC에 의해 ER 염색에 대해 <1% 염색을 나타내는 경우, "ER 음성"으로 평가된다. 따라서, 상기 본원에 제공된 3가지 범주로부터, "ER 음성"의 평가는 IHC에 의해 ER에 대한 <1% 염색을 기준으로 한다.
유사하게, "ER 음성" 발현은 당해 분야에서 통상적으로 사용되는 다른 방법들에 의해 측정될 수 있다. 예를 들면, "ER 음성"은 mRNA/RNA 발현 수준이 낮거나 부재하는 경우에 측정될 수 있다. 사용될 통상적인 방법은 다음을 포함하나, 이로 한정되지는 않는다: 알레드 점수(Allred score), IRS, 렘멜 점수(Remmele score) 또는 임의의 다른 적당한 생화학 검출 방법. 당해 분야에 숙련된 자라면 상기 방법들에 대한 컷-오프(cut-off)가 IHC에 의한 상기 정의된 바와 같은 컷-오프와 일치해야 함을 인지한다.
본원에서 사용될 프로게스테론 수용체(PR), 에스트로겐 수용체(ER), 예정 사멸 리간드 1(PD-L1), 및/또는 인터페론-감마(IFNγ)의 핵산 서열 및 아미노산 서열은 공지되어 있으며 NCBI와 같은 데이터베이스로부터 검색할 수 있다. 대표적인 서열들은 본원에 제공된다(예를 들면, 서열번호: 38 내지 51 참조).
마커(예를 들면, 예정 사멸 리간드 1(PD-L1) 및/또는 인터페론-감마(IFN-γ))의 컷-오프 값을 수립하고 분석될 개인 또는 환자로부터 수득된 샘플을 측정하기 위해 사용되는 방법 및 샘플 유형은 서로 일치하거나 동일하다. 컷-오프 값, 즉, 그 이상에서 과발현(예를 들면, 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현)이 인정되는 값은 대조군에서 수득될 수 있다. 컷-오프 값, 즉, 그 미만에서 감소된 발현(예를 들면, 대조군에 비해 인터페론-감마(IFN-γ)의 감소된 발현)이 인정되는 값은 대조군에서 수득될 수 있다.
컷-오프 값이 기초하는 대조군은 연구중인 개인/환자들의 군과 일치하도록 선택된다, 즉, 본 발명의 방법이 유방암 또는 위암 각각을 갖는 환자에서 PD-L1 공동치료에 대한 필요를 결정하기 위해 이용되는 경우, 대조군은 또한 유방암 또는 위암 각각을 갖는 환자이다. PDL-1 및 IFN-γ 둘 다에 대한 컷-오프 값을 수립하기 위해 사용되는 대조군은 각각 40명 이상 또는 50명 이상 또는 100명 이상의 개인/환자를 포함한다. 컷-오프보다 높은 발현 수준 또는 상응하는 값은 과발현을 나타내는 것으로 간주되며, 컷-오프 이하의 값은 감소된 발현으로 간주된다.
한 태양에서, 개인/환자로부터의 종양 조직 샘플에서의 "IFN-γ" 발현 수준을 컷-오프 값과 비교한다. 컷-오프보다 높은 값은 IFN-γ의 과발현을 나타내는 것으로 간주되고, 컷-오프 이하의 값은 IFN-γ의 감소된 발현으로 간주된다. 한 태양에서, IFN-γ에 대한 발현 수준이, 대조군에서 수립된 바와 같은 최고 오분위수, 사분위수 또는 삼분위수 각각의 값 이하인 경우에 감소된 발현이 인정된다. 한 태양에서, IFN-γ에 대한 컷-오프는 최고 삼분위수이다. 한 태양에서, 컷-오프 값은 70번째와 80번째 백분위수 사이의 값이다. 한 태양에서, IFN-γ에 대한 컷-오프 값은 73번째 백분위수이다, 즉, 상기 컷-오프보다 높은 값은 IFN-γ의 과발현을 나타내는 것으로 간주되고, 73번째 백분위수 이하의 값은 IFN-γ의 감소된 발현으로 간주된다. 한 태양에서, 샘플(예를 들면, 종양 조직 샘플)에서 IFN-γ 발현이 감소되는(즉, IFN-γ 컷-오프 값 이하인) 경우, 개인/환자는 PD-L1 공동치료를 필요로 하는 것으로 결정된다. 한 태양에서, IFN-γ가 과발현되는(즉, 전술한 바와 같은 IFN-γ 컷-오프 값보다 높은) 경우, 개인/환자는 PDL-1 공동치료가 필요하지 않은 것으로 결정된다.
한 태양에서는, 개인/환자로부터의 종양 조직 샘플에서 PD-L1 발현 수준을 컷-오프 값과 비교한다. 컷-오프보다 높은 값은 PD-L1의 과발현을 나타내는 것으로 간주되고 컷-오프 이하의 값은 PD-L1의 감소된 발현으로 간주된다. 한 태양에서, PDL-1에 대한 발현 수준이, 대조군에서 수립된 바와 같은 50번째 백분위수와 75번째 백분위수 사이의 컷-오프 값보다 높은 경우에 PDL-1에 대한 과발현이 인정된다. 한 태양에서, PDL-1에 대한 과발현은, PDL-1에 대한 발현 수준이 대조군의 50번째 백분위수와 70번째 백분위수 사이의 컷-오프 값보다 높은 경우에 인정된다. 한 태양에서, 개인/환자는, PDL-1이 과발현되는(즉, 측정된 PDL-1 발현 수준이 PDL-1 컷-오프 값보다 높은) 경우, PDL-1 공동치료를 필요로 하는 것으로 결정된다.
다른 한 태양에서, PDL-1에 대한 과발현은 종양 조직 샘플에서 IFN-γ의 감소된 발현 수준을 갖는 개인/환자의 소집단에서 수립된다. 한 태양에서, PDL-1에 대한 과발현은, PDL-1에 대한 발현 수준이 상기 소집단에서 수립된 바와 같은 40번째 백분위수와 65번째 백분위수 사이의 컷-오프 값보다 높은 경우에 인정된다. 한 태양에서, PDL-1에 대한 과발현은, PDL-1에 대한 발현 수준이 상기 소집단에서 수립된 바와 같은 50번째 백분위수와 60번째 백분위수 사이의 컷-오프 값보다 높은 경우에 인정된다. 한 태양에서, IFN-γ의 감소된 발현 수준을 갖는 소집단에서의 PDL-1 발현 수준이 54번째 백분위수보다 높은 경우, 개인/환자는 PDL-1 공동치료가 필요한 것으로 결정된다.
한 태양에서, 종양 조직 샘플에서 IFN-γ 발현이 감소되고(즉, IFN-γ 컷-오프 값 이하) PDL-1이 과발현되는(즉, PDL-1 컷-오프 값보다 높은) 경우, 개인/환자는 PDL-1 공동치료가 필요한 것으로 결정된다.
용어 "대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준"은 본원에서 상기 본원에 정의되고 설명된 바와 같은 "PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준"과 상호교환적으로 사용될 수 있다.
용어 "대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준"은 "IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준"과 상호교환적으로 사용될 수 있다.
본 발명은 하기의 양태들에 관한 것이다.
본 발명은 하기의 단계를 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법에 관한 것이다:
a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER), 예정 사멸 리간드 1(PD-L1), 및 인터페론-감마(IFNγ)의 발현 수준을 시험관내에서 측정하는 단계, 및
b) 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성), PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준, 및 IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은, 그의 암이 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)을 가지고 PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준을 가지고 IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은, 그의 암이 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)을 가지고 PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준을 가지고 IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
본 발명은, 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)을 가지고 PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준을 가지고 IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)의 억제제를 포함하는 약학 조성물에 관한 것이다.
"PD-L1 억제제", "PD-L1 억제제 공동치료", "암", "암 환자", "HER2/neu (ErbB2) 신호전달 경로의 조절제", "화학치료제", "샘플", "발현 수준" 등에 대해 본원에 제공된 모든 설명 및 정의는 본 발명의 상기 양태들에도 필요한 부분만 약간 수정하여 적용된다.
환자로부터의 샘플에서 에스트로겐 수용체(ER), 예정 사멸 리간드 1(PD-L1), 및 인터페론-감마(IFNγ)의 발현 수준은 시험관내에서 동시에 또는 임의의 조합으로 순차적으로 측정될 수 있다. 예를 들면, 에스트로겐 수용체(ER), 예정 사멸 리간드 1(PD-L1), 및 인터페론-감마(IFNγ)의 발현 수준은 동시에 측정될 수 있다. 에스트로겐 수용체(ER)의 발현 수준을 먼저 측정한 후에, 예정 사멸 리간드 1(PD-L1) 및 인터페론-감마(IFNγ)를 측정할 수 있다. 예정 사멸 리간드 1(PD-L1)의 발현 수준을 먼저 측정한 후에, 에스트로겐 수용체(ER) 및 인터페론-감마(IFNγ)를 (동시에 또는 순차적으로) 측정할 수 있다. 인터페론-감마(IFNγ)의 발현 수준을 먼저 측정한 후에, 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)를 (동시에 또는 순차적으로) 측정할 수 있다. 환자로부터의 샘플에서 에스트로겐 수용체(ER), 예정 사멸 리간드 1(PD-L1), 및 인터페론-감마(IFNγ)의 발현 수준 측정의 임의의 순서/조합은 본원에서 예상되고 포함된다.
본원에서는, 제 1 단계로 (1) 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)이 측정되는 경우, 및 제 2 단계로, (2) IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준이 측정되는 경우, 및 제 3 단계로, (3) PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준이 측정되는 경우, 환자를 PD-L1 억제제 공동치료가 필요한 것으로 결정하는 것이 고려된다.
본 발명은 하기의 양태들에 관한 것이다:
본 발명은 하기의 단계를 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법에 관한 것이다:
a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER), 예정 사멸 리간드 1(PD-L1), 및 인터페론-감마(IFNγ)의 발현 수준을 시험관내에서 측정하는 단계, 및
b) 제 1 단계로 (1) 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)이 측정되는 경우, 및 제 2 단계로 (2) IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준이 측정되는 경우, 및 제 3 단계로 (3) PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준이 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은, 그의 암이 제 1 단계로 (1) 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)을 가지고, 제 2 단계로 (2) IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준을 가지고, 제 3 단계로 (3) PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은, 그의 암이 제 1 단계로 (1) 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)을 가지고, 제 2 단계로 (2) IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준을 가지고, 제 3 단계로 (3) PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
본 발명은, 낮거나 부재하는 ER 발현 수준(예를 들면, ER(-)/ER-음성)을 가지고, IFNγ 컷-오프 값 이하의 인터페론-감마(IFNγ)의 발현 수준을 가지고, PDL-1 컷-오프 값보다 높은 예정 사멸 리간드 1(PD-L1)의 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)의 억제제를 포함하는 약학 조성물에 관한 것이다.
"PD-L1 억제제", "PD-L1 억제제 공동치료", "암", "암 환자", "HER2/neu (ErbB2) 신호전달 경로의 조절제", "화학치료제", "샘플", "발현 수준" 등에 대해 본원에 제공된 모든 설명 및 정의는 본 발명의 상기 양태들에도 필요한 부분만 약간 수정하여 적용된다.
하기는 본 발명에 따라서 환자가 PD-L1 억제제 공동치료를 필요로 하는지를 결정하게 하는 예시적인 컷-오프 값에 관한 것이다. 환자로부터의 샘플에서 PD-L1 및/또는 IFN-감마의 발현 수준이 상기 컷-오프 값보다 낮은지 아니면 높은지는 통상적인 기술(예를 들면, 아피메트릭스(Affymetrix))에 의해 용이하게 측정될 수 있다.
유전자 발현 분석이 4.8 이상의 IFN-감마 발현에 대한 결과를 제공하는 경우, 병용 치료(HER2-표적화 및 PDL-1 표적화)가 권장되지 않으며, 추가의 PDL1 평가가 필요하지 않다. 유전자 발현 분석이 4.8 미만의 IFN-감마에 대한 결과를 제공하는 경우, PDL-1의 병행 평가가 필요하다. 이어서, PDL-1 유전자 발현 분석이 5.3 이상의 결과를 제공하는 경우, 병용 치료(HER2-표적화 및 PDL1-표적화)가 권장된다. 상기 예시적인 프로토콜은 도 19에 예시되어 있다.
이와 관련하여, 아피메트릭스는 다음과 같이 수행될 수 있다: 종양 세포로부터의 전체 RNA를 라이트 사이클러 퍼투주맙(Light Cycler Pertuzumab) FFPET RNA 키트(로슈 다이아그노스틱스(Roche Diagnostics))를 사용하여 FFPE 종양 절편으로부터 추출하였다. 하이브리드화를 위해 WT-오베이션 FFPE 시스템(WT-Ovation FFPE System) V2(누겐(Nugen))를 사용하여 RNA를 처리하고, 아피메트릭스 진칩(등록상표) 인간 게놈 U133 플러스 2.0 어레이(Affymetrix GeneChip Human Genome U133 Plus 2.0 Arrays)에 하이브리드화시켰다. 하이브리드화된 어레이를 세척하고, 아피메트릭스 플루이딕스 스테이션(Affymetrix Fluidics Station) 450 상에서 염색하고, 아피메트릭스 진칩(등록상표) 스캐너(Affymetrix GeneChip Scanner) 3000 7G로 스캐닝하였다.
언급한 바와 같이, 환자로부터의 샘플에서 PD-L1 및/또는 IFN-감마의 발현 수준은 아피메트릭스와 같은 통상적인 기술에 의해 측정될 수 있다. 하기는 상기 측정을 위한 대표적인 프로토콜(본원에서 유전자 발현 프로파일링(Gene Expression Profiling)으로 지칭됨)에 관한 것이다:
종양 생검 샘플을 아피메트릭스 HG-U133플러스 2 전체 인간 게놈 마이크로어레이 플랫폼(AFFYMETRIX HG-U133Plus 2 whole Human Genome microarray platform) 상에서 유전자 발현에 대해 프로파일링할 수 있다. 로슈 하이퓨어(Roche HighPure) RNA 추출, 누겐(NuGen) 증폭, 및 표준 아피메트릭스 하이브리드화 및 스캐닝 프로토콜을 사용할 수 있다. 상기 프로토콜 등은 본원에 참고로 인용된다. 모든 어레이 스캔은 통상적으로 표준 아피메트릭스 QC를 통과한다.
원신호의 예비처리를 위해 로버스트 멀티어레이 알고리즘(Robust Multiarray algorithm, RMA)을 사용할 수 있다(Irizarry et al, 2003. World wide web at .ncbi.nlm.nih.gov/pubmed/12925520; 본원에 참고로 인용됨). 해당 유전자에 이용가능한 모든 프로브 세트는 하기에 보고된 바와 같이 검색될 수 있다. 유전자 CD274의 경우, 상기 유전자를 나타내기 위해 여러 프로브 세트가 이용가능했을 때, 유전자를 나타내기 위해 최고 평균 발현 값(주어진 프로브 세트의 발현의 산술 평균으로 정의됨)을 갖는 프로브 세트가 선택되었다:
CD274 ( PDL1 )
PDL1에 대해 선택된 223834_at
227458_at
선택된 프로브 세트는 유전자의 마지막 엑손/3'UTR에 상응하며 모든 알려진 RefSEq mRNA를 포착한다(도 6 참조).
IFNG
210354_at
상기 프로브 세트도 또한 유전자의 마지막 엑손/3'UTR을 나타내며, 모든 알려진 RefSEq mRNA를 포착한다(도 7 참조).
상기에 따라서, 인터페론-감마의 발현 수준은 에스트로겐 수용체(ER)의 발현 수준 전에 및/또는 예정 사멸 리간드 1(PD-L1)의 발현 수준 전에 측정될 수 있다. 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 측정하는 단계는 심지어 생략될 수 있다.
첨부된 실시예에서 보이듯이, PD-L1 공동치료는, 예를 들면, 인터페론-감마(IFNγ)의 발현 수준이 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 이상인 경우, 권장되지 않을 수 있다.
따라서, 본 발명은 하기의 단계를 포함하는, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법을 제공한다:
(a) 상기 환자로부터 수득된 샘플에서 인터페론-감마(IFNγ)의 발현 수준을 시험관내에서 측정하는 단계, 및
(b) 단계 (a)에서 인터페론-감마(IFNγ)의 발현 수준이 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 이상인 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하지 않는 것으로 결정하는 단계
인터페론-감마(IFNγ)의 발현 수준이 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만인 경우, 예정 사멸 리간드 1(PD-L1) 및 선택적으로, 에스트로겐 수용체(ER)의 발현 수준을 상기 환자로부터의 샘플에서 시험관내에서 측정할 수 있다.
따라서, 본 발명은 하기의 단계를 포함하는, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법을 제공한다:
(a) 상기 환자로부터 수득된 샘플에서 인터페론-감마(IFNγ), 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 시험관내에서 측정하는 단계, 및
(b) 인터페론-감마(IFNγ)의 발현 수준이 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만인 경우, 및 낮거나 부재하는 ER 발현 수준 및 선택적으로 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
환자는 본 발명에 따라서 환자로부터의 샘플에서 측정된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 대조군에 비해 증가되는 경우, PD-L1 억제제 공동치료를 필요로 하는 것으로 결정될 수 있다. 예를 들면, 예정 사멸 리간드 1(PD-L1)의 발현 수준은 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 5.3 이상일 수 있다.
본원에 제공된 바와 같은 "PD-L1 억제제", "PD-L1 억제제 공동치료", "암", "암 환자", "HER2/neu (ErbB2) 신호전달 경로의 조절제", "화학치료제", "샘플", "발현 수준" 등에 대해 본원에 제공된 모든 설명 및 정의는 상기와 관련하여 필요한 부분만 약간 수정하여 적용된다.
따라서, 본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은, 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준 및 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 암을 치료하는 방법에 관한 것으로, 상기 방법은, 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 가지고 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
낮거나 부재하는 ER 발현 수준을 가지고, 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준 및 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)의 억제제를 포함하는 약학 조성물이 제공된다.
암의 치료에 사용하기 위한 약학 조성물은 또한 화학치료제를 포함할 수 있다.
상기에 따라서, 본원에 제공된 방법은 상기 샘플에서 인터페론-감마(IFNγ)의 발현 수준을 측정하고, 대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준이 측정되는 경우 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계를 포함할 수 있다. 예를 들면, 인터페론-감마(IFNγ)의 "감소된 발현 수준"은 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만의 발현 수준일 수 있다. 따라서, 대조군에 비해 인터페론-감마(IFNγ)의 감소된 발현 수준을 갖는 것으로 측정되는 암은 아피메트릭스와 같은 통상적인 방법에 의해 측정할 때 (약) 4.8 미만의 인터페론-감마(IFNγ)의 발현 수준을 갖는 것으로 측정될 수 있다.
본원에서 발현 수준은 유전자 산물/단백질의 활성에 반영될 수 있는 것으로 예상된다. 따라서, 본 발명에 따라서 발현 수준 이외에 또는 발현 수준에 대안으로서 또한 ER, PD-L1 및/또는 IFN-γ의 활성을 측정하고 평가할 수 있다. 당해 분야에 숙련된 자는 ER, PD-L1 및 IFN-γ 발현 수준 및/또는 활성을 검출하고 평가하기 위한 상응하는 수단 및 방법을 알고 있다. 사용될 대표적인 방법으로는 웨스턴 블롯(Western Blot), 노던 블롯(Northern Blot), 실시간 PCR 등과 같은 분자 측정이 포함되나, 이로 한정되지는 않는다. 상기 방법들은 본원에서 상세히 기술된다.
ER, PD-L1 및/또는 IFN-γ의 발현 수준은 ER, PD-L1 및/또는 IFN-γ의 mRNA 발현 수준일 수 있다. 유전자 산물이 RNA, 특히 mRNA(예를 들면, 비스플라이싱, 부분 스플라이싱 또는 스플라이싱된 mRNA)인 경우, 측정은 노던 블로팅 기술, 원위치 하이브리드화, mRNA 전사체에 특이적인 하나 이상의 프로브 또는 프로브 세트가 구비된 마이크로어레이 또는 DNA 칩 상에서의 하이브리드화, 또는 PCR 기술, 예를 들면, 실시간 PCR과 같은 정량적 PCR 기술을 이용하여 수행될 수 있다. (특이적) mRNA를 결합시키기 위한 상기 및 기타 적합한 방법은 당해 분야에 공지되어 있으며, 예를 들면, 샘브룩 및 러셀(Sambrook and Russell)의 상기 인용 문헌(2001)에 기술되어 있다. 숙련된 자는 검출 신호 강도와 측정될 유전자 산물의 양 사이의 상관관계, 바람직하게는 선형 상관관계를 이용하여 성분, 특히 상기 유전자 산물의 양을 측정할 수 있다.
발현 수준은 ER, PD-L1 및/또는 IFN-γ의 단백질 발현 수준일 수 있다. 단백질 발현 수준의 정량화는 공지되어 있는 기술, 예를 들면, 웨스턴 블로팅 기술, 면역분석법, 겔- 또는 블롯-기반 방법, IHC, 질량 분석법, 유세포분석, FACS 등을 이용하여 수행할 수 있다. 일반적으로, 당해 분야에 숙련된 자는 폴리펩티드(들)/단백질(들)의 정량화 방법을 알고 있다. 용액중 정제된 폴리펩티드의 양은 물리적 방법, 예를 들면, 광도측정법에 의해 측정할 수 있다. 혼합물 중 특정 폴리펩티드의 정량화 방법은, 예를 들면, 항체의 특이적 결합을 필요로 할 수 있다. 항체의 특이성을 이용하는 특이적 검출 및 정량화 방법은, 예를 들면, 면역조직화학(원위치)을 포함한다. 웨스턴 블로팅은 전기영동에 의한 단백질 혼합물의 분리와 항체를 사용한 특이적 검출을 결합시킨다. 전기영동은 2D 전기영동과 같이 다-차원성일 수 있다. 통상적으로, 폴리펩티드는 한 차원을 따라 그의 겉보기 분자량에 의해서 및 다른 방향을 따라서는 그의 등전점에 의해 2D 전기영동에서 분리된다. 또는, 단백질 정량화 방법은 질량 분석법 또는 효소-결합 면역흡착 분석 방법을 포함할 수 있으나, 이로 한정되지는 않는다.
본 발명의 맥락에서 고속 대량 스크리닝(high throughput screening, HTS)의 사용도 또한 예상된다. 적합한 (HTS) 접근방법은 당해 분야에 공지되어 있다. 당해 분야에 숙련된 자는 용이하게 상기 프로토콜 또는 알고 있는 HTS 접근방법을 본 발명 방법의 수행에 맞춰 조정하는 위치에 있다. 상기 분석은 통상적으로 액체 상에서 수행되며, 여기서, 검사될 각각의 세포/조직/세포 배양물에 대해 하나 이상의 반응 배치가 제조된다. 사용될 전형적인 용기는, 예를 들면, 384, 1536 또는 3456 웰(즉, "원래" 96개 반응 용기의 복합물)을 갖는 미세적정 플레이트이다. 로봇공학, 데이터 처리 및 제어 소프트웨어, 및 민감한 검출기가 HTS 장치의 공통적으로 사용되는 다른 요소들이다. 흔히 로봇 시스템은 샘플(들) 및 시약(들)의 첨가 및 혼합, 시약의 배양 및 최종 판독(검출)을 위해 위치에서 위치로 미세적정 플레이트를 운반하기 위해 사용된다. 통상적으로, HTS는 많은 플레이트의 동시 제조, 배양 및 분석에 사용될 수 있다. 분석은 단일 반응(이것이 통상적으로 바람직하다)으로 수행될 수 있지만, 또한 세척 및/또는 전달 단계를 포함할 수 있다. 검출은 방사능, 발광 또는 형광, 예를 들면, 형광-공명-에너지 전달(FRET) 및 형광 편광(FP) 등을 이용하여 수행될 수 있다. 본원에 기술된 생물 샘플은 또한 상기 맥락에서 사용될 수 있다. 특정 세포 분석 및 생체내 분석이 HTS에 사용될 수 있다. 세포 분석은 또한 세포 추출물, 즉, 세포, 조직 등으로부터의 추출물을 포함할 수 있다. 그러나, 본원에서는 생물 샘플(특히 암을 앓고 있거나 또는 암에 걸리기 쉬운 환자/대상으로부터 수득된 샘플)로서 세포(들) 또는 조직(들)의 사용이 바람직한 반면, 생체내 분석은 본원에 사용될 조절제/억제제/화학치료제의 확인에 특히 유용하다. 첫번째 분석의 결과에 따라서, 실험을 반복하여 좁혀진 세트(예를 들면, 첫번째 분석에서 "양성"으로 밝혀진 샘플) 상에서 추가의 데이터를 수집하고, 확인하고, 관찰결과를 개선함으로써 후속 분석이 수행될 수 있다.
본 발명 방법의 맥락에서 사용된 바와 같이, "대조군"의 비-제한 예는 바람직하게는 PD-L1 억제제 공동치료를 필요로 하지 않는 환자로부터의 대조군, 예를 들면, 1명 이상의 건강한 대상, 또는 암/종양을 앓고 있고 PD-L1 억제제 공동치료를 필요로 하지 않는 것으로 알려진 1명 이상의 환자로부터 수득된 샘플/세포/조직이다. 예를 들면, 상기 대조군(샘플)은 추가의 PD-L1 억제제 공동치료로부터 이익을 얻지 못하는 환자로부터 수득될 수 있다. "대조군"의 또 다른 비제한 예는 "내부 표준물", 예를 들면, 정제되거나 합성적으로 생성된 단백질 및/또는 펩티드 또는 RNA의 혼합물이며, 이때 각각의 단백질/펩티드/RNA의 양은 상기 기술된 대조군을 사용하여 측정된다.
"대조군"의 다른 비-제한 예는 "건강한" 대조군, 예를 들면, 암/종양을 앓고 있지 않는 건강한 대상 또는 환자로부터 수득된 샘플/세포/조직 또는 상기 대상으로부터 수득된 세포일 수 있다. 상기에 따라서, ER, PD-L1 및/또는 IFN-γ의 기준 또는 대조군 발현 수준은 상응하는 건강한 대조군 대상/환자(의 샘플)에서 측정된 것이다, 즉, ER, PD-L1 및/또는 IFN-γ의 "정상적" 상태이다. 대조군은 또한 암을 앓고 있는 것으로 추정되는 개인 또는 환자로부터 수득된 샘플/세포/조직일 수 있으나, 단 상기 샘플/세포/조직은 종양 또는 암 세포를 함유하지 않는다. 다른 대안으로, "대조군"은 암의 발생 또는 진단 이전에 수득된, 암을 앓고 있는 개인 또는 환자로부터 수득된 샘플/세포/조직일 수 있다.
본원에 제공된 방법에 따라 평가될 샘플은 비-질환 세포 및/또는 질환 세포, 즉, 비-암성 세포 및/또는 암성 세포를 포함할 수 있다. 그러나, 비-암성 세포중 암성 세포의 함량은, 예를 들면, 50%보다 높아야 한다. 샘플은 또한 (또는 심지어 전적으로) 암/종양 세포(들), 예를 들면, 유방암/종양 세포(들)을 포함할 수 있다. 용어 "샘플"은 일반적으로 환자의 종양으로부터 수득된 임의의 생물 샘플을 의미한다. 샘플은 조직 절편 또는 조직 생검물일 수 있다. 샘플은 또한 전이성 병변, 또는 전이성 병변의 절편, 또는 순환 종양 세포를 포함하는 것으로 알려지거나 추정되는 혈액 샘플일 수 있다. 상기에 따라서, 생물 샘플은 암 세포 및 어느 정도, 즉, 예를 들면, 50% 미만의 비-암 세포(기타 세포)를 포함할 수 있다. 숙련된 병리학자는 정상 조직 세포로부터 암 세포를 식별할 수 있다. 포유동물, 예를 들면, 인간으로부터 조직 생검물, 조직 절제물 및 체액 등을 수득하기 위한 방법은 당해 분야에 공지되어 있다.
상기에서 설명한 바와 같이, 본 발명에 따라 PD-L1 억제제 공동치료가 필요한 것으로 결정되는 암 환자는 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있거나, 또는 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 상기 치료가 상기 환자에게 고려된다. HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료는 "HER2-양성 암"을 갖는 환자, 예를 들면, HER2-양성 암을 앓고 있는 것으로 추정되거나, HER2-양성 암을 앓고 있거나 또는 HER2-양성 암에 걸리기 쉬운 환자에게 권고된다. 바람직하게, 본 발명에 따라서, 치료될 암은 "HER2-양성 암", 특히 "HER2-양성 유방암"이다. "HER2-양성 암"은 "HER2-양성 유방암" 또는 "HER2-양성 위암"일 수 있다. 또한, HER2-양성 암은 난소암, 폐암, 대장암, 신장암, 뼈암, 골수암, 방광암, 피부암, 전립선암, 식도암, 침샘암, 췌장암, 간암, 두경부암, CNS(특히 뇌) 암, 자궁경부암, 연골암, 결장암, 비뇨기암, 위장관암, 췌장암, 활막암, 고환암, 흉선암, 갑상선암 및 자궁암일 수 있다.
본원에서 사용된 바와 같은 용어 "HER2-양성 암"은 정상 수준보다 높은 HER2를 갖는 암 세포를 포함하는 암/종양 조직 등을 말한다. 본 발명에 있어서, "HER2-양성 암"은 적어도 2+의 면역조직화학(IHC) 점수 및/또는 ≥2.0(즉, ISH-양성)의 원위치 하이브리드화(ISH) 증폭비를 갖는다. 따라서, HER2-양성 암은, 예를 들면, 면역조직화학 방법에 의해 검출된 높은 HER2 (단백질) 발현 수준 및/또는 원위치 하이브리드화에 의해 검출된 HER2 유전자 증폭(IHS 양성, 예를 들면, 종양 세포당 4개 복체물보다 많은 HER2 유전자 복제수 또는 HER2 유전자 복제수 대 CEP17.에 대한 신호의 수에 대해 ≥2.0의 비)이, 환자로부터 수득된 샘플, 예를 들면, 유방 조직 생검물 또는 유방 조직 절제물 또는 전이 부위로부터 수득된 조직에서 발견되는 경우에 존재한다. 한 태양에서, "HER2-양성 암"은 HER2의 면역조직화학(IHC) 점수(3+)를 가지고/가지거나 ISH 양성이다.
HER2의 발현 수준은 면역조직화학 방법에 의해 검출할 수 있는 반면, 상기 HER2 유전자 증폭 상태는 원위치 하이브리드화 방법, 예를 들면, 형광 원위치 하이브리드화 기술(FISH)로 측정할 수 있다. 단백질 발현 분석 및 유전자 증폭의 검출에 대해, 상응하는 분석법 및 키트는 당해 분야에 공지되어 있다. 또는, qRT-PCR과 같은 다른 방법들을 이용하여 HER2 유전자 발현의 수준을 검출할 수 있다.
HER2의 발현 수준은, 특히, 면역조직화학 방법에 의해 검출할 수 있다. 상기 방법은 당해 분야에 공지되어 있으며, 상응하는 상업적 키트가 시판된다. 본 발명에 따라 사용될 수 있는 대표적인 키트는, 특히, 다코(Dako)사에 의해 생산되고 유통되는 허셉트테스트(HerceptTest, 등록상표) 또는 벤타나 패쓰웨이(Ventana Pathway, 등록상표)로 지칭되는 검사이다. HER2 단백질 발현의 수준은 허셉테스트(등록상표)를 사용하여 제공된 시약을 사용하고 허셉테스트(등록상표)의 프로토콜에 따라서 평가할 수 있다. 숙련된 자라면 면역조직화학 방법에 의해 HER2의 발현 수준을 측정하기 위한 다른 수단 및 방법을 인지할 것이다; 예를 들면, WO 2005/117553 호 참조. 그러므로, HER2의 발현 수준은 과도한 부담없이 당해 분야에 숙련된 자에 의해 용이하고 재현가능하게 측정될 수 있다. 그러나, 정확하고 재현가능한 결과를 보장하기 위해, 검사는 전문 실험실에서 수행되어야 하며, 이에 의해 검사 절차의 검증이 보장될 수 있다.
HER2의 발현 수준은 낮은 발현 수준, 중간 발현 수준 및 높은 발현 수준으로 분류될 수 있다. 본 발명의 맥락에서 HER2-양성 질환은, 예를 들면, 암 환자의 샘플에서 측정된, HER2의 강한 발현 수준(예를 들면, IHC에 의한 HER2(3+))으로 정의되는 것이 바람직하다.
본원에서 HER2(0), HER2(+), HER2(++) 및 HER2(+++)로 명시된 HER2의 발현 수준을 반영하는 IHC 염색 패턴을 평가하기 위한 권장 점수 체계는 다음과 같다:
Figure 112015051247986-pct00001

상기 IHC 염색 패턴은 통상적으로 HER2-양성 유방암을 측정하는데 사용된다. 본원에서 사용되는 용어 HER2(+), HER2(++) 및 HER2(+++)는 용어 HER2(1+), HER2(2+) 및 HER2(3+)와 등가이다. 본 발명에서 사용된 "낮은 단백질 발현 수준"은 0 또는 1+ 점수(본원에서 상기에 나타낸 표에 따라서 "음성 평가")에 상응하고, "약함 내지 중간 단백질 발현 수준"은 2+ 점수("약함 내지 중간 과발현, 상기 표 참조)에 상응하고, "높은 단백질 발현 수준"은 3+ 점수("강한 과발현", 상기 표 참조)에 상응한다. 상기 본원에서 상세히 기술된 바와 같이, 단백질 발현 수준의 평가(즉, 표에 나타낸 바와 같은 점수 체계)는 면역조직화학 방법에 의해 수득된 결과를 기초로 한다. 표준으로서 또는 통상적으로, HER-2 상태평가는 따라서 시판하는 2개의 FDA-승인된 상업적 키트; 즉 다코 허셉테스트(등록상표) 및 벤타나 패쓰웨이(등록상표) 중 하나를 사용하여 면역조직화학에 의해 수행된다. 이들은 발현 수준을 0(세포당 <20,000개 수용체, IHC 염색에 의해 가시적인 발현 없음), 1+(세포당 약 100,000개 수용체, 부분적인 막 염색, <10%의 세포가 HER-2 과발현), 2+(세포당 약 500,000개 수용체, 약간 내지 중간정도의 완전한 막 염색, >10%의 세포가 HER-2 과발현) 및 3+(세포당 약 2,000,000개 수용체, 강한 완전 막 염색, >10%의 세포가 HER-2 과발현)로 계층화시키는 반-정량적 분석법들이다.
또는, HER2의 단백질 발현 수준의 평가를 위한 다른 방법, 예를 들면, 웨스턴 블롯, ELISA-기반 검출 시스템 등을 이용할 수 있다.
HER2-양성 암은 또한 HER2의 유전자 증폭 상태를 평가함으로써 진단될 수 있다. 따라서, HER2-양성 암은, ISH에 의한 상기 평가가 양성인 경우에 진단된다. 상기 평가에 따르면, HER2-양성 암은 특히, 종양 세포당 HER2 유전자의 4개 복제물보다 높은 평균 HER2 유전자 복제수(내부 동원체(centromere) 대조군 프로브를 갖지 않는 검사 시스템의 경우), 또는 >= 2.0의 HER2/CEP17 비(내부 염색체 17 동원체 대조군 프로브를 사용하는 검사 시스템의 경우)와 관련된다. 즉, HER2-양성 암은 특히 4보다 큰 HER2 유전자 복제수와 관련될 수 있다. HER2 유전자의 증폭 수준은 형광 원위치 하이브리드화(FISH), 색원체 원위치 하이브리드화(CISH) 및 은 원위치 하이브리드화(SISH)와 같은 원위치 하이브리드화(ISH)에 의해 용이하게 확인할 수 있다. 상기 방법들은 숙련된 전문가에게 공지되어 있다. 상기 방법들의 원리는 표준 교재들로부터 추론될 수 있다. 원위치 하이브리드화에 의해 HER2 유전자 증폭 상태를 측정하기 위한 상업적 키트가 시판중이다.
하기의 IHC 염색 패턴이 HER2-양성 위암을 측정하기 위해 권장된다(다코 허셉테스트 패키지 삽입물 참조).
허셉테스트(등록상표) 염색된 생검물들 중에서, 5개 이상의 염색된 종양 세포의 무리가 권장된다. 5개 이상의 염색된 종양 세포의 무리는 5개의 결합된 HER2 염색 종양 세포로 이루어진다.
[표 9]
HER2 면역조직화학 염색의 해석 및 점수
Figure 112015051247986-pct00002
문헌 [Hofmann et al.(40)]에 기초한 가이드라인.
HER2-양성 위암을 측정하기 위한 보다 개선된 IHC 염색 패턴은 다음과 같다:
Figure 112015051247986-pct00003

상기에 나타낸 바와 같이, 본 발명에 따라 치료될 HER2 양성 암은 유방암, 예를 들면, 초기 단계 유방암일 수 있다. 본원에서 사용된 바와 같은 용어 "초기-단계 유방암"은 유방 또는 겨드랑이 림프절을 넘어 퍼지지 않은 유방암을 말한다. 상기 암은 일반적으로 선행보조 또는 보조 치료로 치료될 수 있다. 본원에서 사용된 바와 같은 용어 "선행보조 치료"는 수술전에 제공된 전신 치료를 말한다. 용어 "보조 치료"는 수술후에 제공된 전신 치료를 말한다. 상기에 따라서, 치료는 초기-단계 유방암의 선행보조 또는 보조 치료일 수 있다.
상기에 따라서, 평가될 샘플은 상기 정의된 바와 같은 HER2-양성 암을 갖는 환자로부터일(수득될) 수 있다. 예를 들면, 상기 샘플은 종양 조직, 종양(들)로부터 수득될 수 있으며, 따라서, 유방 종양 등과 같은 HER2-양성 종양인 것으로 추정되는 종양 세포(들) 또는 종양 조직(들)이다. 당해 분야에 숙련된 자는 상기 종양 및/또는 당해 분야에 공지된 표준 기술 및 본원에 개시된 방법을 이용하여 상응하는 암을 앓고 있는 개인/환자를 확인하는 위치에 있다. 일반적으로, 상기 종양 세포 또는 암 세포는 임의의 생물학적 공급원/유기체, 특히 상기-언급한 암을 앓고 있는 임의의 생물학적 공급원/유기체로부터 수득될 수 있다. 본 발명의 맥락에서, 특히 유용한 세포는 바람직하게는 인간 세포이다. 상기 세포들은, 예를 들면, 생검물로부터 또는 생물 샘플로부터 수득될 수 있다. 종양/암/종양 세포/암 세포는 고형 종양/암/종양 세포/암 세포이다. 상기에 따라서, 암/종양 세포는 유방암/종양 세포일 수 있거나, 또는 상기 샘플은 암/종양 세포, 예를 들면, 유방암/종양 세포를 포함한다. 상기에 따라서, 상기 종양/암은 유방 종양/암일 수 있다.
HER2/neu (ErbB2) 신호전달 경로의 조절제는 HER2의 억제제, 예를 들면, HER 이량체화/신호전달 억제제일 수 있다. HER 이량체화 억제제는 HER2 이량체화 억제제일 수 있다. HER 이량체화 억제제는 HER 헤테로이량체화 또는 HER 호모이량체화를 억제할 수 있다. HER 이량체화 억제제는 항-HER 항체일 수 있다. 용어 "항체"는 본원에서 가장 광의로 사용되며, 특히 비손상 단클론성 항체, 다클론성 항체, 2개 이상의 비손상 항체로부터 생성된 다중특이성 항체(예를 들면, 이중특이성 항체), 및 목적하는 생물 활성을 나타내는 경우의 항체 단편들을 포함한다. 또한 인간 및 인간화 뿐 아니라 CDR-그라프팅된 항체도 포함된다.
HER 항체는 EGFR, HER2 및 HER3으로 이루어진 군에서 선택된 HER 수용체에 결합할 수 있다. 바람직하게, 항체는 HER2에 결합한다. 항 HER2 항체는 HER2 세포외 도메인의 도메인 II에 결합할 수 있다. 항체는 HER2 세포외 도메인의 도메인 I, II 및 III 사이의 연결부에 결합할 수 있다. 항 HER2 항체는 퍼투주맙일 수 있다.
본 발명에 있어서, "퍼투주맙" 및 "rhuMAb 2C4"는 상호교환적으로 사용되며, 가변 경쇄 및 중쇄 도메인(도 2에 도시된 바와 같이, 각각 서열번호 5 및 6에 나타낸 그의 아미노산 서열)을 포함하는 항체를 말한다. 변이체 574/퍼투주맙의 가변 경쇄 및 가변 중쇄 도메인도 또한 도 2에 나타내었다(도 2에 도시된 바와 같이, 각각 서열번호 7 및 8에 나타낸 그의 아미노산 서열). 퍼투주맙이 비손상 항체인 경우, 이것은 바람직하게는 IgG1 항체를 포함하며; 그 중에 경쇄 아미노산 서열을 포함하는 한 태양에서, 바람직하게는 각각 도 3a/3b 및 5a/5b(도 5a/5b는 변이 퍼투주맙의 경쇄 및 중쇄 아미노산 서열을 나타낸다)에 나타낸 바와 같은 경쇄 및 중쇄 아미노산 서열을 포함한다. 도 3b에 나타낸 바와 같은 퍼투주맙의 중쇄 아미노산 서열은 선택적으로 C-말단에서 위치 449에 추가의 아미노산 "K"를 포함할 수 있다. 항체는 선택적으로 재조합 차이니즈 햄스터 난소(Chinese Hamster Ovary, CHO) 세포에 의해 생성된다. 용어 "퍼투주맙" 및 "rhuMAb 2C4"는 본원에서 미국 채택명(United States Adopted Name, USAN) 또는 국제 일반명(International Nonproprietary Name, INN): 퍼투주맙(Pertuzumab)을 갖는 약물의 바이오시밀러(biosimilar) 버전을 포함한다. 또한, 상응하는 서열들을 도 2 내지 5에 나타내었다.
HER2/neu (ErbB2) 신호전달 경로의 조절제는 HER 박리의 억제제, 예를 들면, HER2 박리 억제제일 수 있다. HER 박리의 억제제는 HER 헤테로이량체화 또는 HER 호모이량체화를 억제할 수 있다. 상기 HER 박리의 억제제는 항-HER 항체일 수 있다.
용어 "항체"는 본원에서 가장 광의로 사용되며, 특히 비손상 단클론성 항체, 다클론성 항체, 2개 이상의 비손상 항체로부터 생성된 다중특이성 항체(예를 들면, 이중특이성 항체), 및 목적하는 생물 활성을 나타내는 경우의 항체 단편들을 포함한다. 또한 인간 및 인간화 뿐 아니라 CDR-그라프팅된 항체도 포함된다.
항-HER 항체는 EGFR, HER2 및 HER3으로 이루어진 군에서 선택된 HER 수용체에 결합할 수 있다. 바람직하게, 항체는 HER2에 결합한다. 항 HER2 항체는 HER2 세포외 도메인의 도메인의 서브-도메인 IV에 결합할 수 있다. 바람직하게, HER2 항체는 허셉틴(등록상표)/트라스투주맙일 수 있다.
본 발명에 있어서, "허셉틴(등록상표)"/"트라스투주맙" 및 rhuMAb4D5-8"은 상호교환적으로 사용되며, 가변 경쇄 도메인 및 가변 중쇄 도메인(그의 아미노산 서열들은 각각 도 4에 나타나 있으며; 도메인은 화살표로 나타내었다)을 포함하는 항체를 말한다. 트라스투주맙이 비손상 항체인 경우, 이것은 바람직하게는 IgG1 항체를 포함하며; 한 태양에서, 도 4에 나타낸 바와 같은 경쇄 및 중쇄 아미노산 서열을 포함한다. 항체는 선택적으로 차이니즈 햄스터 난소(CHO) 세포에 의해 생성된다. 용어 "트라스투주맙" 및 "rhuMAb4D5-8"는 본원에서 미국 채택명(USAN) 또는 국제 일반명(INN): 트라스투주맙(Trastuzumab)을 갖는 약물의 바이오시밀러 버전을 포함한다.
예정 사멸 리간드 1(PD-L1)의 억제제는 PD-L1에 특이적으로 결합하는 항체(항-PD-L1 항체)일 수 있다. 또한, 용어 "항체"는 가장 광의로 사용되며, 특히 비손상 단클론성 항체, 다클론성 항체, 2개 이상의 비손상 항체로부터 생성된 다중특이성 항체(예를 들면, 이중특이성 항체), 및 목적하는 생물 활성을 나타내는 경우의 항체 단편들을 포함한다. 또한 인간 및 인간화 뿐 아니라 CDR-그라프팅된 항체도 포함된다.
대표적인 항-PD-L1 항체가 본원에 전체로 인용된 WO 2010/077634 호에 개시되어 있다. 본 발명에 따라 사용될 상응하는 대표적인 항-PD-L1 항체를 하기에 기술한다.
항-PD-L1 항체는 HVR-H1, HVR-H2 및 HVR-H3 서열을 포함하는 중쇄 가변 영역 폴리펩티드를 포함할 수 있으며, 여기서
(a) HVR-H1 서열은 GFTFSX1SWIH (서열번호: 1)이고;
(b) HVR-H2 서열은 AWIX2PYGGSX3YYADSVKG (서열번호: 2)이고;
(c) HVR-H3 서열은 RHWPGGFDY (서열번호: 3)이고;
여기서 X1은 D 또는 G이고; X2는 S 또는 L이고; X3은 T 또는 S이다. X1은 D일 수 있고; X2는 S일 수 있고, X3은 T일 수 있다.
상기 폴리펩티드는 또한 식: (HC-FR1)-(HVR-H1)-(HC-FR2)-(HVR-H2)-(HC-FR3)-(HVR-H3)-(HC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 중쇄 프레임워크 서열을 포함할 수 있다. 프레임워크 서열은 인간 공통 프레임워크 서열로부터 유도될 수 있다. 프레임워크 서열은 VH 아족 III 공통 프레임워크일 수 있다. 프레임워크 서열들 중 하나 이상은 다음일 수 있다:
HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고,
HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고,
HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고,
HC-FR4는 WGQGTLVTVSA (서열번호: 7)이다.
중쇄 폴리펩티드는 HVR-L1, HVR-L2 및 HVR-L3을 포함하는 가변 영역 경쇄와 함께 존재할 수 있으며, 여기서:
(a) HVR-L1 서열은 RASQX4X5X6TX7X8A (서열번호: 8)이고;
(b) HVR-L2 서열은 SASX9LX10S (서열번호: 9)이고;
(c) HVR-L3 서열은 QQX11X12X13X14PX15T (서열번호: 10)이며;
여기서, X4는 D 또는 V이고; X5는 V 또는 I이고; X6은 S 또는 N이고; X7은 A 또는 F이고; X8은 V 또는 L이고; X9는 F 또는 T이고; X10은 Y 또는 A이며; X11은 Y, G, F 또는 S이고; X12는 L, Y, F 또는 W이고; X13은 Y, N, A, T, G, F 또는 I이고; X14는 H, V, P, T 또는 I이고; X15는 A, W, R, P 또는 T이다.
X4는 D일 수 있고; X5는 V일 수 있고; X6은 S일 수 있고; X7은 A일 수 있고; X8은 V일 수 있고; X9는 F일 수 있고; X10은 Y일 수 있고; X11은 Y일 수 있고; X12는 L일 수 있고; X13은 Y일 수 있고; X14는 H일 수 있고; X15는 A일 수 있다.
폴리펩티드는 또한 식: (LC-FR1)-(HVR-L1)-(LC-FR2)-(HVR-L2)-(LC-FR3)-(HVR-L3)-(LC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 경쇄 프레임워크 서열들을 포함할 수 있다. 프레임워크 서열은 인간 공통 프레임워크 서열로부터 유도될 수 있다. 프레임워크 서열은 VL 카파 I 공통 프레임워크일 수 있다. 프레임워크 서열들 중 하나 이상은 다음일 수 있다:
LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
항-PD-L1 항체(또는 그의 항원 결합 단편)은 중쇄 및 경쇄 가변 영역 서열을 포함할 수 있으며, 여기서:
(a) 중쇄는 HVR-H1, HVR-H2 및 HVR-H3을 포함하고, 이때 또한:
(i) HVR-H1 서열은 GFTFSX1SWIH (서열번호: 1)이고;
(ii) HVR-H2 서열은 AWIX2PYGGSX3YYADSVKG (서열번호: 2)이고;
(iii) HVR-H3 서열은 RHWPGGFDY (서열번호:3)이며;
(b) 경쇄는 HVR-L1, HVR-L2 및 HVR-L3을 포함하고, 이때 또한:
(iv) HVR-L1 서열은 RASQX4X5X6TX7X8A (서열번호: 8)이고;
(v) HVR-L2 서열은 SASX9LX10S (서열번호: 9)이고;
(vi) HVR-L3 서열은 QQX11X12X13X14PX15T (서열번호: 10)이며;
여기서: X1은 D 또는 G이고; X2는 S 또는 L이고; X3은 T 또는 S이고; X4는 D 또는 V일 수 있고; X5는 V 또는 I일 수 있고; X6은 S 또는 N일 수 있고; X7은 A 또는 F일 수 있고; X8은 V 또는 L일 수 있고; X9는 F 또는 T일 수 있고; X10은 Y 또는 A일 수 있고; X11은 Y, G, F 또는 S일 수 있고; X12는 L, Y, F 또는 W일 수 있고; X13은 Y, N, A, T, G, F 또는 I일 수 있고; X14는 H, V, P, T 또는 I일 수 있고; X15는 A, W, R, P 또는 T일 수 있다.
X1은 D일 수 있고; X2는 S일 수 있고, X3은 T일 수 있다. 또한, 위치는 다음과 같을 수 있다: X4 = D, X5 = V, X6 = S, X7 = A 및 X8 = V, X9 = F, 및 X10 = Y, X11 = Y, X12 = L, X13 = Y, X14 = H 및/또는 X15 = A. 또한, 위치는 다음과 같을 수 있다: X1 = D, X2 = S 및 X3 = T, X4 = D, X5 = V, X6 = S, X7 = A 및 X8 = V, X9 = F, 및 X10 = Y, X11 = Y, X12 = L, X13 = Y, X14 = H 및 X15 = A.
항체(그의 항원 결합 단편)은 또한 다음을 포함할 수 있다:
(a) 식: (HC-FR1)-(HVR-H1)-(HC-FR2)-(HVR-H2)-(HC-FR3)-(HVR-H3)-(HC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 중쇄 프레임워크 서열, 및
(b) 식: (LC-FR1)-(HVR-L1)-(LC-FR2)-(HVR-L2)-(LC-FR3)-(HVR-L3)-(LC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 경쇄 프레임워크 서열. 프레임워크 서열은 인간 공통 프레임워크 서열로부터 유도될 수 있다.
가변 영역 중쇄 프레임워크 서열은 VH 아족 III 공통 프레임워크일 수 있다. 프레임워크 서열들 중 하나 이상은 다음일 수 있다:
HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고,
HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고,
HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고,
HC-FR4는 WGQGTLVTVSA (서열번호: 7)이다.
가변 영역 경쇄 프레임워크 서열은 VL 카파 I 공통 프레임워크일 수 있다. 프레임워크 서열들 중 하나 이상은 다음일 수 있다:
LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
항체(또는 그의 항원 결합 단편)은 다음일 수 있거나 또는 다음을 포함할 수 있다:
(a) 가변 중쇄 프레임워크 서열은 다음이다:
(i) HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고;
(ii) HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고;
(iii) HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고;
(iv) HC-FR4는 WGQGTLVTVSA (서열번호: 7)이며;
(b) 가변 경쇄 프레임워크 서열은 다음이다:
(i) LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
(ii) LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
(iii) LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
(iv) LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
항체(또는 그의 단편)은 또한 인간 불변 영역을 포함할 수 있다. 불변 영역은 IgG1, IgG2, IgG3 및 IgG4로 이루어진 군에서 선택될 수 있다. 불변 영역은 IgG1일 수 있다. 항체(또는 그의 단편)은 또한 뮤린 불변 영역을 포함할 수 있다. 불변 영역은 IgG1, IgG2A, IgG2B 및 IgG3으로 이루어진 군에서 선택될 수 있다. 불변 영역은 IgG2A일 수 있다.
항체(또는 그의 단편)은 감소되거나 또는 최소 작동인자 기능을 가질 수 있다. 최소 작동인자 기능은 작동인자-배제 Fc 돌연변이로부터 야기될 수 있다. 작동인자-배제 Fc 돌연변이는 N297A일 수 있다. 작동인자-배제 Fc 돌연변이는 D265A/N297A일 수 있다. 최소 작동인자 기능은 비글리코실화로부터 비롯될 수 있다.
항체(또는 그의 단편)은 중쇄 및 경쇄 가변 영역 서열을 포함할 수 있으며, 여기서:
(a) 중쇄는 GFTFSDSWIH (서열번호: 15), AWISPYGGSTYYADSVKG (서열번호: 16) 및 RHWPGGFDY (서열번호: 3) 각각에 대해 85% 이상의 전체 서열 동일성을 갖는 HVR-H1, HVR-H2 및 HVR-H3을 포함하고,
(b) 경쇄는 RASQDVSTAVA (서열번호: 17), SASFLYS (서열번호: 18) 및 QQYLYHPAT (서열번호: 19) 각각에 대해 85% 이상의 전체 서열 동일성을 갖는 HVR-L1, HVR-L2 및 HVR-L3을 포함한다.
서열 동일성은 90% 이상일 수 있다.
항체(또는 그의 단편)은 또한 다음을 포함할 수 있다:
(a) 식: (HC-FR1)-(HVR-H1)-(HC-FR2)-(HVR-H2)-(HC-FR3)-(HVR-H3)-(HC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 중쇄(VH) 프레임워크 서열, 및
(b) 식: (LC-FR1)-(HVR-L1)-(LC-FR2)-(HVR-L2)-(LC-FR3)-(HVR-L3)-(LC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 경쇄(VL) 프레임워크 서열.
항체(또는 그의 단편)은 또한 인간 공통 서열로부터 유도된 VH 및 VL 프레임워크 영역을 포함할 수 있다. VH 프레임워크 서열은 카밧(Kabat) 아족 I, II 또는 III 서열로부터 유도될 수 있다. VH 프레임워크 서열은 카밧 아족 III 공통 프레임워크 서열일 수 있다. VH 프레임워크 서열은 다음일 수 있다:
HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고,
HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고,
HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고,
HC-FR4는 WGQGTLVTVSA (서열번호: 7)이다.
VL 프레임워크 서열은 카밧 카파 I, II, III 또는 IV 아족 서열로부터 유도될 수 있다. VL 프레임워크 서열은 카밧 카파 I 공통 프레임워크 서열일 수 있다.
VL 프레임워크 서열은 다음일 수 있다:
LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
항체(또는 그의 단편)은 중쇄 및 경쇄 가변 영역 서열을 포함할 수 있으며, 여기서:
(a) 중쇄 서열은 중쇄 서열: EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPG KGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSA (서열번호: 20)에 대해 85% 이상의 서열 동일성을 가지고,
(b) 경쇄 서열은 경쇄 서열: DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGK APKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKR(서열번호: 21)에 대해 85% 이상의 서열 동일성을 갖는다.
서열 동일성은 90% 이상일 수 있다.
항체(또는 그의 단편)은 중쇄 및 경쇄 가변 영역 서열을 포함할 수 있으며, 여기서:
(a) 중쇄는 서열: EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWIS PYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSA(서열번호: 20)을 포함하고,
(b) 경쇄는 서열: DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSA SFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKR(서열번호: 21)을 포함한다.
또한, 항-PD-L1 항체는 핵산에 의해 암호화될 수 있다. 따라서, 본원에는 상기 폴리펩티드/항체(또는 그의 단편)을 암호화하는 단리된 핵산이 기술되어 있다.
본원에는 항-PD-L1 항체 또는 항원 결합 단편의 경쇄 또는 중쇄 가변 서열을 암호화하는 단리된 핵산이 제공되며, 여기서:
(a) 중쇄는 또한 GFTFSDSWIH (서열번호: 15), AWISPYGGSTYYADSVKG (서열번호: 16) 및 RHWPGGFDY (서열번호: 3) 각각에 대해 85% 이상의 전체 서열 동일성을 갖는 HVR-H1, HVR-H2 및 HVR-H3을 포함하고,
(b) 경쇄는 또한 RASQDVSTAVA (서열번호: 17), SASFLYS (서열번호: 18) 및 QQYLYHPAT (서열번호: 19) 각각에 대해 85% 이상의 전체 서열 동일성을 갖는 HVR-L1, HVR-L2 및 HVR-L3을 포함한다.
서열 동일성은 90% 이상일 수 있다. 항-PD-L1 항체는 또한 인간 공통 서열로부터 유도된 VL 및 VH 프레임워크 영역을 포함할 수 있다. VH 서열은 카밧 아족 I, II 또는 III 서열로부터 유도될 수 있다. VL 서열은 카밧 카파 I, II, III 또는 IV 아족 서열로부터 유도될 수 있다. 항-PD-L1 항체는 뮤린 항체로부터 유도된 불변 영역을 포함할 수 있다. 항-PD-L1 항체는 인간 항체로부터 유도된 불변 영역을 포함할 수 있다. 불변 영역은 IgG1일 수 있다. 핵산에 의해 암호화된 항체는 감소되거나 최소 작동인자 기능을 가질 수 있다. 최소 작동인자 기능은 작동인자-배제 Fc 돌연변이로부터 야기될 수 있다. 작동인자-배제 Fc 돌연변이는 N297A일 수 있다.
본원에는 또한 상기 핵산을 포함하는 벡터, 상기 벡터를 포함하는 숙주 세포가 제공된다. 숙주 세포는 진핵세포일 수 있다. 숙주 세포는 포유동물일 수 있다. 숙주 세포는 차이니즈 햄스터 난소(CHO) 세포일 수 있다. 숙주 세포는 원핵세포일 수 있다. 숙주 세포는 이. 콜라이(E. coli)일 수 있다. 본원에는 또한, 상기 숙주 세포를 항-PD-L1 항체 또는 항원 결합 단편을 암호화하는 벡터의 발현에 적합한 조건하에서 배양하고, 항체 또는 단편을 회수하는 것을 포함하는, 항-PD-L1 항체의 제조 방법이 제공된다.
다음은 암 및/또는 암 환자를 치료하기 위한 본원에 제공된 수단 및 방법을 보다 상세히 기술한다.
따라서, 본원에서는 낮거나 부재하는 ER 발현 수준을 가지며 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu(ErbB2) 신호전달 경로의 조절제(예를 들면, 트라스투주맙) 및 예정 사멸 리간드 1(PD-L1)의 억제제(예를 들면, 본원에 기술된 항-PD-L1 항체)를 포함하는 약학 조성물이 고려된다. 상기 암은 대조군에 비해 인터페론 감마(IFNγ)의 감소된 발현 수준을 갖는 것으로 측정될 수 있다. 약학 조성물은 또한 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))를 포함할 수 있다.
상기에 따라서, 본 발명은 효과량의 HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1)의 억제제를 그를 필요로 하는 대상에게 투여하는 것을 포함하는, 암을 치료하는 방법을 제공한다. 상기 암은 대조군에 비해 인터페론 감마(IFNγ)의 감소된 발현 수준을 갖는 것으로 측정될 수 있다.
본원에는 낮거나 부재하는 ER 발현 수준을 가지며 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu(ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)의 억제제가 제공된다. 또한, 본원에는 낮거나 부재하는 ER 발현 수준을 가지며 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu(ErbB2) 신호전달 경로의 조절제, 예정 사멸 리간드 1(PD-L1)의 억제제 및 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))가 제공된다. 상기 암은 대조군에 비해 인터페론 감마(IFNγ)의 감소된 발현 수준을 갖는 것으로 측정될 수 있다.
상기에서 논의된 바와 같이, 본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되는 암 환자에서 암을 치료하는 방법을 제공하며, 상기 방법은 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 효과량의 HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1) 억제제를 환자에게 투여하는 것을 포함한다. 유사하게, 본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 암을 치료하는 방법을 제공하며, 상기 방법은 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 환자에게 효과량의 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함한다.
본원에서 "암", "암 환자", "PD-L1 억제제", "PD-L1 억제제 치료", "HER2/neu (ErbB2) 신호전달 경로의 조절제", "화학치료제", "낮거나 부재하는 ER 발현 수준", "예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준", "인터페론-감마(IFNγ)의 감소된 발현 수준" 등과 관련하여 상기에 제공된 설명 및 정의는 본 발명의 맥락에서 필요한 부분만 약간 수정하여 적용된다.
용어 "치료", "치료하는" 등은 본원에서 일반적으로 목적하는 약리학적 및/또는 생리학적 효과를 수득하는 것을 의미하기 위해 사용된다. 효과는 질환 또는 그의 증상을 완전히 또는 부분적으로 예방하는 면에서 예방적일 수 있고/있거나, 질환 및/또는 질환에 기인한 이상 반응을 부분적으로 또는 완전히 치료하는 면에서 치료적일 수 있다. 본원에서 사용된 바와 같은 용어 "치료"는 환자에서 질환의 임의의 치료를 포함하며, (a) 질환에 걸릴 성향이 있을 수 있는 환자에서 관련된 질환을 예방하거나; (b) 질환을 억제, 즉, 그의 진행을 막거나; 또는 (c) 질환을 완화, 즉, 질환의 관해를 야기하는 것을 포함한다.
본 발명에 있어서 "환자"는 인간 및 다른 동물, 특히 포유동물 둘 다, 및 기타 유기체를 포함한다. 따라서, 상기 방법은 인간 치료 및 수의학 용도 모두에 적용가능하다. 바람직하게, 환자는 인간이다.
하기의 설명은 보다 상세하게 본 발명에 따른 상기 환자들/상기 환자군의 처치/치료에 관한 것이다.
약학 조성물은, 개개 환자의 임상 상태, 약학 조성물의 전달 부위, 투여 방법, 투여 일정, 및 전문의에게 알려져 있는 다른 요인들을 고려하여, 올바른 의료 행위에 부합하는 방식으로 제형화되고 투약될 수 있다. 따라서, 본 발명에 있어서 약학 조성물의 "효과량"은 상기 고려사항들에 의해 결정된다.
숙련된 자는 개인에게 투여되는 약학 조성물 중 본원에 기술된 PD-L1 억제제(들), HER2/neu (ErbB2) 신호전달 경로의 조절제(들) 및 화학치료제(들) 중 하나의 효과량이 특히 화합물의 성질에 따라 달라질 것임을 인지한다. 예를 들면, 상기 화합물이 (폴리)펩티드 또는 단백질인 경우, 용량 당 비경구적으로 투여되는 약학 조성물의 전체 약학적 효과량은 약 1 ㎍ 단백질/kg/일 내지 10 mg 단백질/kg/일의 환자 체중의 범위일 것이지만, 상기 언급했듯이, 이것은 치료 재량에 따른 문제일 것이다. 보다 바람직하게, 상기 용량은 0.01 mg 단백질/kg/일 이상, 가장 바람직하게는 인간의 경우 약 0.01 내지 1 mg 단백질/kg/일이다.
투라스투주맙과 관련하여 하기의 투여량이 사용될 수 있다:
약량학 및 투여 방법
HER2 검사는 의무적으로 치료 개시 이전에 한다. 허셉틴 치료는 세포독성 화학치료제의 투여에 경험이 있는 의사에 의해 개시되어야만 한다.
MBC
3주간 스케줄
권장 초기 부하 용량은 8 mg/kg 체중이다. 3주 간격으로 권장 유지 용량은 부하 용량 3주후에 시작하여, 6 mg/kg 체중이다.
주간 스케줄
허셉틴의 권장 초기 부하 용량은 4 mg/kg 체중이다. 허셉틴의 매주 권장 유지 용량은 부하 용량 1주후에 시작하여, 2 mg/kg 체중이다.
파클리탁셀 또는 도세탁셀과 함께 투여:
본 임상시험(H0648g, M77001)에서, 파클리탁셀 또는 도세탁셀을 허셉틴의 1차 용량 다음날(용량에 관해서는, 파클리탁셀 또는 도세탁셀에 대한 제품 특징 요약(Summary of Product Characteristics) 참조), 및 허셉틴의 사전 용량이 잘 허용된 경우 허셉틴의 후속 용량 직후에 투여하였다.
아로마타제 억제제와 함께 투여:
본 임상시험(BO16216)에서, 허셉틴 및 아나스트로졸을 제 1일부터 투여하였다. 투여시 허셉틴 및 아나스트로졸의 상대적 타이밍에는 제한이 없었다(용량에 관해서는, 아나스트로졸 또는 다른 아로마타제 억제제에 대한 제품 특징 요약 참조).
3주간 및 주간 스케줄
3주 요법으로서, 허셉틴의 권장 초기 부하 용량은 8 mg/kg 체중이다. 3주 간격으로 허셉틴의 권장 유지 용량은 부하 용량 3주 후에 시작하여 6 mg/kg 체중이다.
주간 요법(4 mg/kg의 초기 부하 용량에 이어 매주 2 mg/kg)으로서, 독소루비신 및 사이클로포스파미드를 사용한 화학치료에 이어 파클리탁셀과 함께(화학치료 병용 투약에 관한 섹션 5.1 참조).
MGC
3주간 스케줄
권장 초기 부하 용량은 8 mg/kg 체중이다. 3주 간격으로 권장 유지 용량은 부하 용량 3주후에 시작하여 6 mg/kg 체중이다.
유방암(MBC 및 EBC) 및 위암(MGC)
치료 기간
MBC 또는 MGC를 갖는 환자는 질환의 진행까지 허셉틴으로 치료되어야 한다. EBC를 갖는 환자는 처음에 발생한 것이 무엇이든 1년동안 또는 질환 재발까지 허셉틴으로 치료되어야 한다.
용량 감소
임상 시험동안 허셉틴 용량은 감소시키지 않았다. 환자들은 가역적 화학치료-유도된 골수억제 기간동안 치료를 지속할 수 있지만, 상기 시간동안 호중구감소증의 합병증에 대해 주의깊게 모니터링해야 한다. 용량 감소 또는 지연에 관한 정보를 위해서는 파클리탁셀, 도세탁셀 또는 아로마타제 억제제에 대한 제품 특징 요약을 참조한다.
놓친 용량
환자가 1주일 이하까지 허셉틴의 용량을 거른 경우, 통상적인 유지 용량(주간 요법: 2 mg/kg; 3주간 요법: 6 mg/kg)을 가능한 한 빨리 제공하여야 한다. 다음 예정된 주기까지 기다리지 않는다. 이어서, 후속의 유지 용량(주간 요법: 2 mg/kg; 3주간 요법: 6 mg/kg)이 이전 스케줄에 따라 제공되어야 한다.
환자가 1주일이 넘어서까지 허셉틴의 용량을 거른 경우, 허셉틴의 재-부하 용량이 약 90 분에 걸쳐 제공되어야 한다(주간 요법: 4 mg/kg; 3주간 요법: 8 mg/kg). 이어서, 상기 시점부터 후속 허셉틴 유지 용량(주간 요법: 2 mg/kg; 3주간 요법: 6 mg/kg)이 제공되어야 한다(주간 요법: 매주; 3주간 요법: 3주마다).
특수 환자 집단
임상 데이터는 허셉틴의 조치가 연령 또는 혈청 크레아티닌에 근거하여 변화되지 않음을 보여준다. 임상 시험에서, 노인 환자들은 감소된 용량의 허셉틴을 투약받지 않았다. 노인 및 신장 또는 간 손상이 있는 노인들에서의 전문 약동학적 연구는 수행되지 않았다. 그러나, 집단 약동학 분석에서, 연령 및 신장 손상이 트라스투주맙 조치에 영향을 미치는 것으로 나타나지 않았다.
투여 방법
허셉틴 부하 용량은 90-분 정맥내 주입으로 투여되어야 한다. 급속 정맥내 주입(intravenous push or bolus)으로 투여하지 않는다. 허셉틴 정맥내 주입은 아나필락시스를 관리하도록 준비된 의료인에 의해 투여되어야 하며, 응급 키트가 이용가능해야 한다. 환자는 첫번째 주입 개시후 적어도 6 시간동안 및 후속 주입 개시후 2 시간동안 발열 및 오한과 같은 증상 또는 다른 주입-관련 증상(섹센 4.4 및 4.8 참조)에 대해 관찰되어야 한다. 주입 중단 또는 속도 지연은 상기 증상을 제어하는 것을 도울 수 있다. 증상이 약해지면 주입을 재개할 수 있다.
초기 부하 용량이 잘 허용되면, 후속 용량들을 30-분 주입으로 투여할 수 있다. 본 발명의 약학 조성물은 비경구적으로 투여될 수 있다.
본 발명의 약학 조성물은 바람직하게는 약학적으로 허용되는 담체를 포함한다. "약학적으로 허용되는 담체"는 임의 유형의 무독성 고체, 반고체 또는 액체 충전제, 희석제, 캡슐화 물질 또는 제형화 보조제를 의미한다. 본원에서 사용된 바와 같은 용어 "비경구적"은 정맥내, 근육내, 복강내, 흉골내, 피하 및 관절내 주사 또는 주입을 포함하는 투여 방식을 말한다. 본원에 제공된 조성물의 투여는 특히 하루 2회, 매일, 격일, 3일마다, 4일마다, 5일마다, 1주일에 1회, 2주에 1회, 3주에 1회, 매월 1회 등의 투여를 포함할 수 있다.
약학 조성물은 또한 서방성 시스템에 의해 적절히 투여된다. 서방성 조성물의 적당한 예로는 성형품, 예를 들면, 필름 또는 마이크로캡슐 형태의 반-투과성 중합체 매트릭스가 포함된다. 서방성 매트릭스로는 폴리락티드(미국 특허 제 3,773,919 호, EP 58,481 호), L-글루탐산과 감마-에틸-L-글루타메이트의 공중합체[Sidman, U. et al., Biopolymers 22:547-556 (1983)], 폴리(2-하이드록시에틸 메타크릴레이트)[R. Langer et al., J. Biomed. Mater. Res. 15:167-277 (1981), and R. Langer, Chem. Tech. 12:98-105 (1982)], 에틸렌 비닐 아세테이트[R. Langer et al., Id.] 또는 폴리-D-(-)-3-하이드록시부티르산(EP 133,988 호)이 포함된다. 서방성 약학 조성물은 또한 리포좀에 봉입된 화합물을 포함한다. 약학 조성물을 함유하는 리포좀은 자체로 공지된 방법에 의해 제조된다: DE 3,218,121 호; [Epstein et al., Proc. Natl. Acad. Sci. (USA) 82:3688-3692 (1985); Hwang et al., Proc. Natl. Acad. Sci. (USA) 77:4030-4034 (1980)]; EP 52,322 호; EP 36,676 호; EP 88,046 호; EP 143,949 호; EP 142,641 호; 일본 특허출원 제 83-118008 호; 미국 특허출원 제 4,485,045 및 4,544,545 호; 및 EP 102,324 호. 통상적으로, 리포좀은 지질 함량이 약 30 몰%보다 큰 콜레스테롤인 작은(약 200 내지 800 Å) 단일라멜라 유형으로, 상기 선택된 비율은 최적의 치료를 위해 조정된다.
비경구 투여의 경우, 약학 조성물은 일반적으로, 목적하는 정도의 순도에서 단위 투여형 주사가능한 형태(용액, 현탁액 또는 유화액)로 약학적으로 허용되는 담체, 즉, 사용되는 투여량 및 농도에서 수용자에게 무독성이고 제형의 다른 성분들과 상용성인 담체와 혼합시켜 제형화된다.
일반적으로, 제형은 약학 조성물의 성분들을 액체 담체 또는 미분 고체 담체 또는 둘 다와 균일하고 균질하게 접촉시킴으로써 제조된다. 이어서, 필요한 경우, 생성물을 목적하는 제형으로 성형시킨다. 바람직하게, 담체는 비경구 담체, 보다 바람직하게는 수용자의 혈액과 등장성인 용액이다. 상기 담체 비히클의 예로는 물, 식염수, 링거액(Ringer's solution) 및 덱스트로스 용액이 포함된다. 불활성 오일 및 에틸 올리에이트와 같은 비-수성 비히클 뿐 아니라, 리포좀도 또한 본 발명에서 유용하다. 담체는 적절하게 미량의 첨가제, 예를 들면, 등장성 및 화학 안정성을 증대시키는 물질을 함유한다. 상기 물질은 사용되는 투여량 및 농도에서 수용자에게 무독성이며, 완충제, 예를 들면, 포스페이트, 시트레이트, 숙시네이트, 아세트산, 및 기타 유기산 또는 그의 염; 산화방지제, 예를 들면, 아스콜브산; 저분자량(약 10개 잔기 미만) (폴리)펩티드, 예를 들면, 폴리아르기닌 또는 트라이펩티드; 단백질, 예를 들면, 혈청 알부민, 젤라틴 또는 면역글로불린; 친수성 중합체, 예를 들면, 폴리비닐피롤리돈; 아미노산, 예를 들면, 글리신, 글루탐산, 아스파트산 또는 아르기닌; 모노사카라이드, 다이사카라이드, 및 셀룰로스 또는 그의 유도체, 글루코스, 만노스 또는 덱스트린을 포함한 기타 탄수화물; 킬레이트화제, 예를 들면, EDTA; 당 알콜, 예를 들면, 만니톨 또는 솔비톨; 상대이온, 예를 들면, 나트륨; 및/또는 비이온성 계면활성제, 예를 들면, 폴리솔베이트, 폴록사머 또는 PEG를 포함한다.
치료적 투여에 사용될 약학 조성물의 성분들은 멸균성이어야 한다. 멸균성은 멸균 여과 막(예를 들면, 0.2 마이크론 막)을 통한 여과에 의해 용이하게 달성된다. 약학 조성물의 치료 성분은 일반적으로 멸균 접근 입구를 갖는 용기, 예를 들면, 정맥내 용액 주머니 또는 피하 주사 바늘에 의해 천공될 수 있는 마개를 갖는 바이알에 담길 수 있다.
약학 조성물의 성분은 통상적으로 단위 또는 다중-용량 용기, 예를 들면, 밀봉 앰플 또는 바이알에, 수용액으로서 또는 재구성을 위한 동결건조된 제형으로서 저장될 것이다. 동결건조 제형의 한 에로서, 10 ml 바이알을 5 ml의 멸균-여과된 1%(w/v) 수용액으로 충전시키고, 수득된 혼합물을 동결건조시킨다. 주입 용액은 동결건조된 화합물(들)을 정균 주입용수(Water-for-Injection)를 사용하여 재구성시켜 제조된다.
HER2/neu (ErbB2) 신호전달 경로의 조절제, 예정 사멸 리간드 1(PD-L1)의 억제제 및 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))를 포함하는 본원에 제공된 암 치료는 상기 치료의 개개 성분들의 동시, 순차적 또는 별도의 투여에 의해 수행될 수 있다. 예를 들면, 본원에 정의된 바와 같은 HER2/neu (ErbB2) 신호전달 경로의 조절제(들)(예를 들면, 트라스투주맙) 중 하나 이상은 본원에 정의된 예정 사멸 리간드 1(PD-L1)의 억제제(들) 중 하나 이상(예를 들면, 본원에 정의되고 기술된 항-PD-L1 항체)과 동시에 투여될 수 있다. 또한, 본 발명에 따라 사용될 하나 이상의 본원에 정의된 예정 사멸 리간드 1(PD-L1)의 억제제(들)(예를 들면, 본원에 제공되고 기술된 항-PD-L1 항체)과 동시에 투여될 수 있는 본원에 정의된 바와 같은 HER2/neu (ErbB2) 신호전달 경로의 조절제(들)(예를 들면, 트라스투주맙)의 순차적 투여도 본원에서 예상된다. 본원에 정의된 바와 같은 HER2/neu (ErbB2) 신호전달 경로의 본원에 정의된 조절제(들)(예를 들면, 트라스투주맙) 및 하나 이상의 본원에 정의된 예정 사멸 리간드 1(PD-L1)의 억제제(예를 들면, 본원에 정의되고 기술된 항-PD-L1 항체)는 또한 별개로 투여될 수 있다. 예를 들면, 본원에 정의된 바와 같은 HER2/neu (ErbB2) 신호전달 경로의 하나 이상의 조절제(들)(예를 들면, 트라스투주맙)이 제 1 단계로 투여되고 이어서 제 2 단계에서 하나 이상의 예정 사멸 리간드 1(PD-L1)의 억제제(들)(예를 들면, 본원에 정의되고 기술된 항-PD-L1 항체)과 함께 투여될 수 있으며, 그 반대도 마찬가지이다. 유사하게, 화학치료제는 동시에, 순차적으로 또는 별개로 투여될 수 있다. HER2/neu (ErbB2) 신호전달 경로의 조절제(들), 예정 사멸 리간드 1(PD-L1)의 억제제(들) 및 화학치료제(들)(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어, 등록상표))의 동시, 순차 또는 별개 투여의 임의의 조합이 본원에서 예상된다.
HER2/neu (ErbB2) 신호전달 경로의 조절제, 예정 사멸 리간드 1(PD-L1)의 억제제 및 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))를 포함하는 본원에 제공된 암 치료는 단독 치료로서 적용될 수 있다. 그러나, 상기 치료는 하나 이상의 추가의 치료(즉, 추가의 공동치료로), 예를 들면, 수술과, 방사선치료 및/또는 하나 이상의 추가의 화학치료제와 같은 통상적인 치료와 함께 적용될 수 있다.
수술은, HER2/neu (ErbB2) 신호전달 경로의 조절제, 예정 사멸 리간드 1(PD-L1)의 억제제 및 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))를 포함하는 본원에 제공된 암 치료 투여 전에, 중에 또는 후에, 부분적 또는 완전 종양 절제 단계를 포함할 수 있다. 본원에 제공된 HER2/neu (ErbB2) 신호전달 경로의 조절제, 예정 사멸 리간드 1(PD-L1)의 억제제 및 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))는 선행보조요법 또는 보조요법 환경(특히, 암의 선행보조 또는 보조 치료)에서 투여될 수 있다.
HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1)의 억제제는 선행보조요법 환경에서 투여될 수 있다. HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1)의 억제제는 보조요법 환경 또는 전이 환경에서 투여될 수 있다.
따라서, 본원에 제공된 HER2/neu (ErbB2) 신호전달 경로의 조절제, 예정 사멸 리간드 1(PD-L1)의 억제제 및 화학치료제(예를 들면, 탁솔 또는 탁솔 유도체, 예를 들어, 도데탁셀(탁소테어(등록상표)))는 암 조직의 수술적 개입/절제 중에 또는 후에 상기 치료를 필요로 하는 환자에게 투여될 수 있다. 그러므로, 본 발명은 선행보조 치료, 즉 수술전에 그를 필요로 하는 환자/환자군에게 주어진 본원에 제공된 치료법에 의한 치료에 유용하다. 본 발명은 또한 보조 치료(즉, 수술후)에도 유용하다.
본 발명에서 사용될 화학치료제는 바람직하게는 탁산(용어 "탁솔"은 본원에서 "탁산"과 상호교환적으로 사용된다) 또는 탁산 유도체(탁솔 유도체), 예를 들면, 도데탁셀(탁소테어(등록상표)) 또는 파클리탁셀이다. 도데탁셀/(탁소테어(등록상표))의 사용이 본 발명에서 특히 바람직하다.
(추가의) 화학치료제(들)은 하기의 예시적인 비-제한 약물 또는 약제들 중 하나 이상일 수 있다:
시스플라틴(Cisplatin), 비노렐빈(Vinorelbin), 카보플라틴(Carboplatin), 파클리탁셀(Paclitaxel), 겜시타빈(Gemcitabin), 도세탁셀(Docetaxel), 베바시주맙(Bevacizumab), 페메트렉세드(Pemetrexed), 에토포시드(Etoposid), 이리노테칸(Irinotecan), 이포스파미드(Ifosfamid), 토포테칸(Topotecan),
항-혈관신생제(들), 예를 들면, VEGF 차단제(예를 들면, 베바시주맙/아바스틴(Avastin) 또는 수텐트(수니티닙 말레이트-SU-11248)), 리노마이드, 인테그린 ανβ3 기능 억제제, 안지오스타틴, 라족신, 탈리도마이드, 및 혈관 표적화제(예를 들면, 콤브레타스타틴 포스페이트 또는 N-아세틸콜치놀-O-포스페이트) 포함;
세포성장억제제(들), 예를 들면, 항에스트로겐(예를 들면, 타목시펜, 토레미펜, 랄록시펜, 드롤록시펜, 요오독시펜), 프로게스토겐(예를 들면, 메게스트롤 아세테이트), 아로마타제 억제제(예를 들면, 아나스트로졸, 레트라졸, 보라졸, 엑세메스탄), 항프로게스토겐, 항안드로겐(예를 들면, 플루타미드, 닐루타미드, 비칼루타미드, 시프로테론 아세테이트), LHRH 작용물질 및 길항물질(예를 들면, 고세렐린 아세테이트, 루프롤리드), 테스토스테론 5α-다이하이드로리덕타제의 억제제(예를 들면, 피나스테리드), 항-침습제(예를 들면, 메탈로프로테이나제 억제제, 예를 들어, 마리마스타트, 및 우로키나제 플라스미노겐 활성화제 수용체 기능의 억제제) 및 성장 인자 기능의 억제제(상기 성장 인자는, 예를 들면, 혈소판 유래 성장 인자 및 간세포 성장 인자를 포함하며, 상기 억제제는 성장 인자 항체, 성장 인자 수용체 항체, 티로신 키나제 억제제 및 세린/트레오닌 키나제 억제제를 포함한다);
생물 반응 조절제(예를 들면, 인터페론); 항-대사물질 약제(들)(예를 들면, 겜시타빈); 항-호르몬 화합물(들), 예를 들면, 항-에스트로겐(들); 항체(예를 들면, 에드레콜로맙); 보조 (항-)호르몬 치료/치료들(즉, 보조 (항-)호르몬 약물(들), 예를 들어, 타목시펜을 사용한 치료); 유전자 치료 접근방법(예를 들면, 안티센스 치료); 및/또는 면역치료 접근방법.
화학치료는 또한 (추가로), 티로신 키나제 억제제(들), raf 억제제(들), ras 억제제(들), 이중 티로신 키나제 억제제(들), 탁솔, 탁산(들)(예를 들면, 파클리탁셀 또는 도세탁셀), 안트라사이클린(들), 예를 들면, 독소루비신 또는 에피루비신, 아로마타제 억제제(예를 들면, 아나스트로졸 또는 레트로졸) 및/또는 비노렐빈과 같이, 의료 종양학에서 사용되는 바와 같은 하나 이상의 항증식성/항신생물 약물 및 그의 조합의 사용을 포함하며; 사이클로포스파미드, 메토트렉세이트 또는 플루오로우라실(5-FU로도 알려져 있음)은, 선택적으로 임의의 다른 본원에 제공된 추가의 치료와 함께, 상기 공동치료에 개별적으로 또는 상기 3개 약물을 포함하는 공동치료("CMF 치료")의 형태로 사용될 수 있다. 본 발명의 병용 치료에 사용하기 위한 화학치료제의 특정한 예들은 다음이다: 페메트렉세드, 랄티트렉세드, 에토포시드, 비노렐빈, 파클리탁셀, 도세탁셀, 시스플라틴, 옥살리플라틴, 카보플라틴, 겜시타빈, 이리노테칸(CPT-l), 5-플루오로우라실(5-FU(카페시타빈 포함)), 독소루비신, 사이클로포스파마이드, 테모졸로마이드, 하이드록시우레아, (iii) 의료 종양학에 사용되는 바와 같은 항증식성/항신생물 약물 및 그의 조합, 예를 들면, 항대사물질(예를 들면, 항엽산제, 예를 들어, 메토트렉세이트, 플루오로피리미딘, 예를 들면, 5-플루오로우라실, 퓨린 및 아데노신 유사체, 시토신 아라비노시드); 항종양 항생물질(예를 들면, 안트라사이클린, 예를 들어, 독소루비신, 다우노마이신, 에피루비신 및 이다루비신, 미토마이신-C, 닥티노마이신, 미트라마이신); 백금 유도체(예를 들면, 시스플라틴, 카보플라틴); 알킬화제(예를 들면, 질소 머스터드, 멜팔란, 클로람부실, 부설판, 사이클로포스파미드, 이포스파미드, 니트로소우레아, 티오테파); 항유사분열제(예를 들면, 빈카 알칼로이드, 예를 들어, 빈크리스틴 및 탁소이드, 예를 들어, 탁솔, 탁소테어); 토포이소머라제 억제제(예를 들면, 에피포도필로톡신, 예를 들어, 에토포시드 및 테니포시드, 암사크린, 토포테칸, 및 또한 이리노테칸); 또한 효소(예를 들면, 아스파라기나제); 및 티미딜레이트 신타제 억제제(예를 들면, 랄티트렉세드); 및 또 다른 유형의 화학치료제.
본 발명에 따라 사용하기 위한 억제제/조절제/화학치료제는 본원에 기술되어 있으며, 일반적으로 공지되어 있고/있거나 상업적으로 시판하는 억제제/조절제/화학치료제를 말한다. 그러나, 또한 아직 제조될 억제제 또는 그의 억제 활성에 대해 시험될 공지된 화합물들의 사용도 본 발명의 맥락에서 예상된다.
다른 태양에서, 본 발명은 HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제와 함께 PD-L1 억제제 공동치료에 대한 환자의 필요를 결정하기 위한, ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 검출할 수 있는 핵산(들) 또는 항체(항체들)의 용도에 관한 것이다. 상기 용어들 각각의 설명은 상기에 제공되었으며 여기서 필요한 부분만 약간 수정하여 적용된다.
바람직하게, 핵산(예를 들면, 올리고뉴클레오티드(들))은 약 15 내지 100개 뉴클레오티드의 길이이다. 당해 분야에 숙련된 자라면 용이하게, 그의 일반적인 지식 및 본원에 제공된 교지내용에 근거하여, ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 검출할 수 있는 올리고- 또는 폴리뉴클레오티드를 확인하고/하거나 제조하는 위치에 있다. 특히, 상기 핵산(들)(예를 들면, 올리고- 또는 폴리뉴클레오티드)은 본원에 기술된 방법에서, 예를 들면, 발현 수준의 측정에 프로브(들)로서 사용될 수 있다. 숙련된 자라면, 예를 들면, 본원에 사용될 상응하는 프로브의 확인에 유용할 수 있는 컴퓨터 프로그램을 알 것이다. 예를 들면, 에스트로겐 수용체를 암호화하는 핵산(또는 핵산의 일부)(예를 들면, 서열번호: 38), PD-L1을 암호화하는 핵산(또는 핵산의 일부)(예를 들면, 서열번호: 42), 및 선택적으로, IFNγ를 암호화하는 핵산(또는 핵산의 일부)(예를 들면, 서열번호: 44)을 상기 맥락에서 ER, PD-L1 및 IFNγ 각각의 발현 수준을 검출하기 위한 특이적 프로브를 확인하기 위해 사용할 수 있다. ER, PD-L1 및 IFNγ를 암호화하는 대표적인 핵산 서열들은 상응하는 데이터베이스, 예를 들면, NCBI 데이터베이스(ncbi.nlm.nih.gov/ sites/entrez의 월드 와이드 웹)에서 이용가능하다.
또한, 본원에는 선택적으로 ER, PD-L1 및 IFNγ의 발현 수준을 검출/측정/평가하기 위한 수단을 추가로 포함하는 진단 조성물인 조성물이 제공된다. 상기 검출 수단은, 예를 들면, 전술한 뉴클레오티드 및/또는 항체이다. 따라서, 본 발명은 PD-L1 억제제 공동치료를 필요로 하는 환자를 결정하기 위한 진단 조성물의 제조를 위한 상기 수단(예를 들면, 상기 뉴클레오티드 및/또는 항체)에 관한 것이다.
대안적 양태에서, 본 발명은 PD-L1 억제제 공동치료를 필요로 하는 환자를 결정하는데 사용하기 위한 상기 검출 수단(예를 들면, 전술한 핵산 및/또는 항체 및/또는 본 발명에 따라 사용될 키트와 관련하여 하기에 기술되는 "결합 분자")에 관한 것이다. 바람직하게, 본 발명은 PD-L1 억제제 공동치료를 필요로 하는 환자를 결정하는데 사용하기 위한 항체/항체들에 관한 것이다.
뿐만 아니라, 본 발명은 또한 ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 검출할 수 있는 핵산 또는 항체를 포함하는, 본원에 제공된 방법을 수행하는데 유용한 키트에 관한 것이다. 본원에서는 또한 본원에 제공된 방법을 수행하기 위한, 본원에 기술된 키트의 용도가 예상된다. 본원에 기술된 방법 및 용도를 수행하는데 유용한 상기 키트는 ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 측정할 수 있는 올리고뉴클레오티드 또는 폴리뉴클레오티드를 포함할 수 있다. 예를 들면, 상기 키트는 ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 특이적으로 측정하기 위해 필요한 화합물(들)을 포함할 수 있다. 더욱이, 본 발명은 또한 본 발명의 방법 또는 용도를 수행하기 위한 키트의 제조를 위한, ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 특이적으로 측정하기 위해 필요한 화합물(들)의 용도에 관한 것이다. 본 발명의 교지내용에 근거하여, 숙련된 자는 어느 화합물(들)이 ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 특이적으로 측정하기 위해 필요한지를 인지한다. 에를 들면, 상기 화합물(들)은 "결합 분자(들)"일 수 있다. 특히, 상기 화합물(들)은 ER 유전자/암호화 서열, PD-L1 유전자/암호화 서열 및 선택적으로 IFNγ/암호화 서열의 (유전자) 산물에 특이적인 (뉴클레오티드) 프로브(들), 프라이머(들)(쌍(들)), 항체(들) 및/또는 압타머(들)일 수 있다. 본 발명의 (맥락에서 제조될) 키트는 진단 키트일 수 있다.
본 발명의 (맥락에서 제조될) 키트 또는 본 발명의 방법 및 용도는 또한 사용 매뉴얼(들)을 포함하거나 제공될 수 있다. 예를 들면, 상기 사용 매뉴얼(들)은 숙련된 자가 ER, PD-L1 및 선택적으로 IFNγ의 (기준/대조군) 발현 수준을 (어떻게) 측정하는 방법 또는 PD-L1 억제제 치료에 대한 환자의 필요를 (어떻게) 측정하는 방법을 지도할 수 있다. 특히, 상기 사용 매뉴얼(들)은 본원에 제공된 방법 또는 용도를 사용하거나 적용하기 위한 지침을 포함할 수 있다. 본 발명의 (맥락에서 제조될) 키트는 또한 본 발명의 방법 및 용도를 수행하기에 적합한/필요한 물질/화학물질 및/또는 장비를 포함할 수 있다. 예를 들면, 상기 물질/화학물질 및/또는 장비는 ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 특이적으로 측정하기 위해 필요한 화합물(들)을 안정화시키고/시키거나 저장하기 위한 용매, 희석제 및/또는 완충제이다.
본원에서 사용된 바와 같이, 용어 "이루어지는" 및 "포함하는" 또는 그의 문법적 변형은 언급된 특징, 정수, 단계 또는 성분들을 명시하는 것으로 간주될 것이지만, 그의 하나 이상의 추가의 특징, 정수, 단계, 성분 또는 기의 부가를 배제하지 않는다. 상기 용어는 용어 "로 이루어지는" 및 "로 필수적으로 이루어지는"을 포함한다. 따라서, 용어 "이루어지는"/"포함하는"/"갖는"은 임의의 추가 성분(또는 유사하게 특징, 정수, 단계 등)이 존재할 수 있음을 의미한다.
용어 "로 이루어지는"은 추가의 성분(또는 유사하게 특징, 정수, 단계 등)이 존재할 수 없음을 의미한다.
용어 "로 필수적으로 이루어지는" 또는 그의 문법적 변형은 본원에서 사용될 때 언급된 특징, 정수, 단계 또는 성분들을 명시하는 것으로 간주될 것이지만, 그의 추가의 특징, 정수, 단계, 성분 또는 기가 청구된 조성물, 장치 또는 방법의 기본 및 신규 특징들을 물질적으로 변화시키지 않는 경우에만 그의 하나 이상의 추가의 특징, 정수, 단계, 성분 또는 기의 부가를 배제하지 않는다. 따라서, 용어 "로 필수적으로 이루어지는"은 특정 추가 성분(또는 유사하게 특징, 정수, 단계 등), 즉, 조성물, 장치 또는 방법의 근본적 특징에 물질적으로 영향을 미치지 않는 추가 성분들이 존재할 수 있음을 의미한다. 즉, 용어 "로 필수적으로 이루어지는"(본원에서 용어 "실질적으로 포함하는"과 상호교환적으로 사용될 수 있다)은, 정해진 성분(또는 유사하게 특징, 정수, 단계 등) 이외에 조성물, 장치 또는 방법에 다른 성분들의 존재를 허용하되, 단 장치 또는 방법의 근본적 특징이 다른 성분들의 존재에 의해 물질적으로 영향을 받지 않아야 한다.
용어 "방법"은, 화학, 생물 및 생물물리학 분야의 전문가에게 공지되어 있거나 또는 상기 전문가에 의해 공지된 방식, 수단, 기술 및 절차로부터 용이하게 발전되는 방식, 수단, 기술 및 절차를 포함하여(이로 한정되지는 않는다) 주어진 과제를 달성하기 위한 방식, 수단, 기술 및 절차를 말한다.
본원에서 사용된 바와 같이, 용어 "단리된"은 그의 생체내 위치(예를 들면, 수생 생물 또는 이끼)로부터 제거된 조성물을 말한다. 바람직하게, 본 발명의 단리된 조성물은 실질적으로 그의 생체내 위치에 존재하는 다른 물질들(예를 들면, 항-부착 효과를 포함하지 않는 다른 단백질)이 없다(즉, 정제되거나 또는 반-정제됨).
본원에서 사용된 바와 같이, 용어 "약"은 ±10%를 말한다.
본 발명은 또한 하기의 항목들에 관한 것이다:
1. 하기 단계를 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하는 방법:
a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 시험관내에서 측정하는 단계, 및
b) 낮거나 부재하는 ER 발현 수준 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계
2. 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 효과량의 HER2/neu (ErbB2) 신호전달 경로의 조절제, 화학치료제 및 예정 사멸 리간드 1(PD-L1) 억제제를 상기 환자에게 투여하는 것을 포함하는, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되는 암 환자에서 암을 치료하는 방법.
3. 그의 암이 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암 환자를 선별하고, 상기 환자에게 효과량의 예정 사멸 리간드 1(PD-L1) 억제제를 투여하는 것을 포함하는, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 암을 치료하는 방법.
4. 낮거나 부재하는 ER 발현 수준을 가지고 대조군에 비해 예정 사멸 리간드 1(PD-L1)의 증가된 발현 수준을 갖는 것으로 측정되는 암의 치료에 사용하기 위한, HER2/neu (ErbB2) 신호전달 경로의 조절제 및 예정 사멸 리간드 1(PD-L1)의 억제제를 포함하는 약학 조성물.
5. 화학치료제를 추가로 포함하는, 4 항의 암의 치료에 사용하기 위한 약학 조성물.
6. 환자로부터 수득된 샘플에서 인터페론-감마(IFNγ)의 발현 수준을 시험관내에서 측정하고, 대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준이 측정되는 경우 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 것을 추가로 포함하는, 1 내지 3 항 중 어느 하나의 방법.
7. ER 발현 수준이 ER(-)인, 1, 2, 3 및 6 항 중 어느 하나의 방법; 또는 4 및 5 항의 약학 조성물.
8. 상기 HER2/neu (ErbB2) 신호전달 경로의 조절제가 HER2 항체 허셉틴/트라스투주맙인, 1, 2, 3, 6 및 7 항 중 어느 하나의 방법; 또는 4, 5 및 7 항 중 어느 하나의 약학 조성물.
9. 상기 화학치료제가 탁솔 또는 탁솔 유도체인 1, 2, 3, 6, 7 및 8 항 중 어느 하나의 방법; 또는 5, 7 및 8 항 중 어느 하나의 약학 조성물.
10. 상기 예정 사멸 리간드 1(PD-L1)의 억제제가 PD-L1에 특이적으로 결합하는 항체(항-PD-L1 항체)인 1, 2, 3, 6, 7 및 8 내지 9 항 중 어느 하나의 방법; 또는 4, 5,및 7 내지 9 항 중 어느 하나의 약학 조성물.
11. 상기 암이 고형암인 1, 2, 3 및 6 내지 10 항 중 어느 하나의 방법; 또는 4, 5 및 7 내지 10 항 중 어느 하나의 약학 조성물.
12. 상기 고형암이 유방암 또는 위암인 11 항의 방법; 또는 11 항의 약학 조성물.
13. PD-L1의 발현 수준이 mRNA 발현 수준인 1, 2, 3 및 6 내지 12 항 중 어느 하나의 방법; 또는 4, 5 및 7 내지 12 항 중 어느 하나의 약학 조성물.
14. HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제와 함께 PD-L1 억제제 공동치료에 대한 환자의 필요를 결정하기 위한, ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 검출할 수 있는 핵산 또는 항체의 용도.
15. 상기 HER2/neu (ErbB2) 신호전달 경로의 조절제, 상기 화학치료제 및 상기 예정 사멸 리간드 1(PD-L1)의 억제제가 선행보조요법 환경에서 투여되는 것인, 1, 2, 3 및 6 내지 14 항 중 어느 하나의 방법; 또는 4, 5 및 7 내지 14 항 중 어느 하나의 약학 조성물.
본 발명은 하기의 비-제한 도면 및 실시예를 참고로 하여 더 기술된다. 달리 언급되지 않는 한, 재조합 유전자 기술의 확립된 방법은, 예를 들면, 본원에 전체로 참고로 인용된 문헌 [Sambrook, Russell "Molecular Cloning, A Laboratory Manual", Cold Spring Harbor Laboratory, N.Y. (2001)]에 기술된 바와 같이 사용되었다.
실시예는 본 발명을 예시한다.
실시예 1: HER2 표적화 치료 및 화학치료를 받고 있는 암 환자는, ER 의 발현 수준이 낮거나 부재하는 경우( ER 음성) 및 PD - L1 발현 수준이 증가되는 경우, PD -L1 억제제 공동치료로부터 이익을 얻는다
유전자 발현의 평가는 R 바이오컨덕터(Bioconductor) 패키지 '아피(affy)', R 버전 2.15.0을 사용하여 수행하였다. 모든 탐색적 분석 및 예측 모델은 SAS JMP 버전 10.0을 사용하여 이루어졌다.
48 HER2+, ER+ 및 39 HER2+, ER- 유방암 생검물을 네오스페어(NeoSphere) 임상 시험으로부터 수득하였다. 샘플은 나중에 선행보조요법 환경에서 도세탁셀 및 트라스투주맙으로 치료된 환자로부터 진단시에 취하였다. 기준선에서 주 임상 공변량, 및 수반된 집단에서 임상 반응(수술에서 평가될 때)의 분포는 다음과 같다:
ER 음성 샘플:
환자 연령 (도 17 참조)
분위수
Figure 112015051247986-pct00004

암 유형
Figure 112015051247986-pct00005

pT (종양의 병리학적 병기)
Figure 112015051247986-pct00006

pN (결절의 병리학적 병기)
Figure 112015051247986-pct00007

G (등급)
Figure 112015051247986-pct00008

ER 양성 샘플:
환자 연령 (도 18 참조)
분위수
Figure 112015051247986-pct00009

암 유형
Figure 112015051247986-pct00010

pT
Figure 112015051247986-pct00011

pN
Figure 112015051247986-pct00012

G
Figure 112015051247986-pct00013
에스트로겐 수용체(ER) 상태에 의한 병리학적 완전 반응률(pCR)의 상황의존도 분석(contingency analysis)
Figure 112015051247986-pct00014

유전자 발현 프로파일링
종양 생검 샘플을 아피메트릭스 HG-U133Plus 2 전체 인간 게놈 마이크로어레이 플랫폼 상에서 유전자 발현에 대해 프로파일링하였다. 로슈 하이퓨어 RNA 추출, 누겐 증폭 및 표준 아피메트릭스 하이브리드화 및 스캐닝 프로토콜을 이용하였다. 모든 어레이 스캔은 표준 아피메트릭스 QC를 통과하였다.
로버스트 멀티어레이 알고리즘(RMA)을 원신호의 예비처리에 이용하였다(Irizarry et al, 2003. http://www.ncbi.nlm.nih.gov/ pubmed/12925520). 해당 유전자에 이용가능한 모든 프로브 세트는 하기에 보고된 바와 같이 검색되었다. 유전자 CD274의 경우, 상기 유전자를 나타내기 위해 여러 프로브 세트가 이용가능했을 때, 유전자를 나타내기 위해 최고 평균 발현 값(주어진 프로브 세트의 발현의 산술 평균으로 정의됨)을 갖는 프로브 세트를 선택하였다:
CD274 ( PDL1 )
PDL1에 대해 선택된 223834_at
227458_at
선택된 프로브 세트는 유전자의 마지막 엑손/3'UTR에 상응하며 모든 알려진 RefSEq mRNA를 포착한다(도 6 참조).
IFNG
210354_at
상기 프로브 세트도 또한 유전자의 마지막 엑손/3'UTR을 나타내며, 모든 알려진 RefSEq mRNA를 포착한다(도 7 참조).
도 8은 ER- 및 ER- 집단 둘 다의 샘플에서 상기 유전자의 발현의 결합 분포를 나타낸 것이다. 부호 유형은 최종 pCR 상태에 상응한다(속이 찬것: pCR 달성, 속이 빈것: pCR 달성되지 않음).
ER 및 pCR 층을 교차하여 CD274 및 IFNG 발현의 분포에 대한 보다 상세한 내용은 부록 I에서 확인할 수 있다.
모든 ER 소집단에 대해, 선택된 유전자의 발현을 환자 연령, 암 유형 및 결절 상태에 대해 조정된 임상 반응과 관련시키는 로지스틱 회귀 모델을 구성하였다.
반응 ~ 환자 연령 + 암 유형 + pN + CD274 + IFNG
1. ER - 집단.
요약된 모델 출력결과를 하기에 나타내었다. 오즈비(Odds ratio, OR)는 바이오마커 값의 단위 변화에 대해 제공된다. 발현 값이 log2 등급으로 제공되므로, 1의 단위 변화는 2배 과발현에 상응할 것이다. 세부사항에 대해서는 부록을 참조하시오.
Figure 112015051247986-pct00015

특정 환자가 치료에 반응하는 확률을 예측하기 위한 최종 모델은 CD274 및 IFNG의 발현을 포함하며, 다음과 같다:
p(pCR) = -3.737 + 1.607*CD274 -1.069*IFNG
2. ER + 집단.
요약된 모델 출력결과를 하기에 나타내었다. 오즈비(OR)는 바이오마커 값의 단위 변화에 대해 제공된다. 발현 값이 log2 등급으로 제공되므로, 1의 단위 변화는 2배 과발현에 상응할 것이다. 세부사항에 대해서는 부록을 참조하시오.
Figure 112015051247986-pct00016

PDL1 발현의 역할은 선행보조요법 환경에서 트라스투주맙과 화학치료제에 의한 병용 치료를 받은 HER2+ 유방암 환자의 ER- 소집단에서 명백하다. 즉, 진단시 PDL1의 과발현은 선행보조 치료에 대한 더 낮은 반응 속도(즉, 트라스트주맙과 화학치료제에 의한 병용 치료에 대한 더 낮은 반응 속도)에 상응한다. 이것은 환자 연령, 암 유형 또는 림프절 상태와 무관하게 유지된다. 두 바이오마커 PDL1 및 IFNG 각각의 유전자 발현의 기준선 평가에 의해, PDL-1 표적화 치료가 트라스투주맙 및 화학치료에 부가되는 경우 환자가 더 큰 이익을 경험할 가능성이 있는지가 확인된다.
다음은 환자가 본 발명에 따른 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하게 하는 컷-오프 값에 관한 것이다.
유전자 발현 분석이 4.8 이상의 IFNG 발현에 대한 결과를 제공하는 경우, 병용 치료(HER2-표적화 및 PDL-1 표적화)는 권장되지 않으며 추가의 PDL 1 평가는 필요하지 않다. 유전자 발현 분석이 4.8 미만의 IFNG에 대한 결과를 제공하는 경우, PDL-1의 병행 평가가 필요하다. PDL-1 유전자 발현 분석이 5.3 이상의 결과를 제공하는 경우, 병용 치료(HER2-표적화 및 PDL1-표적화)가 권장된다(도 19 참조).
부록 I
ER - 소집단
pCR ER = ERneg 에 의한 CD274 발현의 일원 분석 (도 9a 참조)
t 검정
있음-없음(YES-NO)
비등분산 가정하에
Figure 112015051247986-pct00017

결과는 또한 도 9b에 나타내었다.
pCR ER = ERneg 에 의한 IFNG 발현의 일원 분석
결과는 도 10a에 나타내었다.
t 검정
있음-없음
비등분산 가정하에
Figure 112015051247986-pct00018

결과는 도 10b에 나타내었다.
ER + 소집단
pCR ER = ERpos 에 의한 CD274 발현의 일원 분석
결과는 도 11a에 나타내었다.
t 검정
있음-없음
비등분산 가정하에
Figure 112015051247986-pct00019

결과는 도 11b에 나타내었다.
pCR ER = ERpos 에 의한 IFNG 발현의 일원 분석
결과는 도 12a에 나타내었다.
t 검정
있음-없음
비등분산 가정하에
Figure 112015051247986-pct00020

결과는 도 12b에 나타내었다.
부록 II
pCR ER=ERneg에 대한 공칭 로지스틱 적합성
구배로 수렴, 5회 반복
전체 모델 시험
Figure 112015051247986-pct00021

Figure 112015051247986-pct00022

Figure 112015051247986-pct00023

적합성 결여
Figure 112015051247986-pct00024
파라미터 평가
Figure 112015051247986-pct00025

없음/있음의 로그 오즈비에 대해
유효 로그우도율 검정
Figure 112015051247986-pct00026

오즈비
없음 대 있음의 pCR 오즈비에 대해
오즈비에 대한 검정 및 신뢰 구간은 우도율을 기준으로 한다.
회귀변인에서 단위 변화 당 단위 오즈비
Figure 112015051247986-pct00027

암 유형에 대한 오즈비
Figure 112015051247986-pct00028

pN에 대한 오즈비
Figure 112015051247986-pct00029

치료수용자 수술 특성(도 13 참조)
양성 수준이 되는 pCR='있음'를 이용하여
Figure 112015051247986-pct00030
혼동 매트릭스
실제값
예측값
Figure 112015051247986-pct00031

리프트 곡선(도 14 참조)
Figure 112015051247986-pct00032

예측 프로파일러(도 15 참조)
pCR ER=ERpos에 대한 공칭 로지스틱 적합성
구배로 수렴, 19회 반복
전체 모델 시험
Figure 112015051247986-pct00033

Figure 112015051247986-pct00034

Figure 112015051247986-pct00035

적합성 결여
Figure 112015051247986-pct00036

파라미터 평가
Figure 112015051247986-pct00037

없음/있음의 오즈비에 대해
유효 우도율 검정
Figure 112015051247986-pct00038

오즈비
없음 대 있음의 pCR 오즈비에 대해
오즈비에 대한 검정 및 신뢰 구간은 우도율을 기준으로 한다.
회귀변인에서 단위 변화 당 단위 오즈비
Figure 112015051247986-pct00039
암 유형에 대한 오즈비
Figure 112015051247986-pct00040

pN에 대한 오즈비
Figure 112015051247986-pct00041

치료수용자 수술 특성(도 16 참조)
양성 수준이 되는 pCR='있음'를 이용하여
Figure 112015051247986-pct00042

혼동 매트릭스
실제값
예측값
Figure 112015051247986-pct00043

본 발명은 하기의 뉴클레오티드 및 아미노산 서열을 참조한다:
본원에 제공된 서열들은 특히 NCBI 데이터베이스에서 이용가능하고 WO 2010/077634 호에 개시되어 있으며, ncbi.nlm.nih.gov/sites/entrez?db=gene의 월드 와이드 웹에서 검색할 수 있다. 상기 서열들은 또한 주석이 달리고 변형된 서열과 관련된다. 본 발명은 또한 본원에 제공된 축약된 서열의 상동성 서열 및 변이체를 사용하는 기술 및 방법을 제공한다.
서열번호 1 내지 21은 본 발명에 따라 사용될 항-PD-L1 항체를 규정한다. 서열번호 1 내지 21은 서열표에 나와 있다.
서열번호 22 내지 37은 HER2 단백질의 도메인 I 내지 IV에 대한 아미노산 서열들의 서열(서열번호 22 내지 25, 또한 도 1 참조) 및 항-HER2-항체의 서열(서열번호 26 내지 37; 또한 도 2 내지 5 참조)을 나타낸다.
서열번호 26:
도 2에 나타낸 바와 같은 뮤린 단클론성 항체 2C4(서열번호 5 및 6 각각)의 가변 경쇄(VL)(도 2a) 도메인의 아미노산 서열.
서열번호 27:
도 2에 나타낸 바와 같은 뮤린 단클론성 항체 2C4의 가변 중쇄(VH)(도 2b) 도메인의 아미노산 서열.
서열번호 28:
도 2에 나타낸 바와 같은 변이체 574/퍼투주맙의 가변 경쇄(VL)(도 2a) 도메인의 아미노산 서열.
서열번호 29:
도 2에 나타낸 바와 같은 변이체 574/퍼투주맙의 가변 중쇄(VH)(도 2b) 도메인의 아미노산 서열.
서열번호 30:
도 2에 나타낸 바와 같은 인간 VL 공통 프레임워크(hum κ1, 경쇄 카파 아족 I; humIII, 중쇄 아족 III).
서열번호 31:
도 2에 나타낸 바와 같은 인간 VH 공통 프레임워크(hum κ1, 경쇄 카파 아족 I; humIII, 중쇄 아족 III).
서열번호 32:
도 3a에 나타낸 바와 같은 퍼투주맙 경쇄의 아미노산 서열.
서열번호 33:
도 3b에 나타낸 바와 같은 퍼투주맙 중쇄의 아미노산 서열.
서열번호 34:
도 4a에 나타낸 바와 같은 트라스투주맙 경쇄 도메인의 아미노산 서열. 가변 경쇄 도메인의 경계를 화살표로 나타내었다.
서열번호 35:
도 4b에 나타낸 바와 같은 트라스투주맙 중쇄의 아미노산 서열. 가변 중쇄 도메인의 경계를 화살표로 나타내었다.
서열번호 36:
변이체 퍼투주맙 경쇄 서열의 아미노산 서열(도 5a).
서열번호 37:
변이체 퍼투주맙 중쇄 서열의 아미노산 서열(도 5b).
서열번호 38:
호모 사피엔스 프로게스테론 수용체(PR)를 암호화하는 뉴클레오티드 서열.
NCBI 기준 서열: NC_000011.9
>gi|224589802:c101000544-100900355 호모 사피엔스 염색체 11, GRCh37.p10 1차 집합
서열번호 39:
호모 사피엔스 프로게스테론 수용체(PR)의 아미노산 서열.
PRGR_HUMAN　 길이: 933　 2012년 12월 07일, 15:10　 유형: P　 체크: 6067　 ..
서열번호 40:
호모 사피엔스 에스트로겐 수용체(ER)를 암호화하는 뉴클레오티드 서열 (NM_000125.3)
서열번호 41:
호모 사피엔스 에스트로겐 수용체(ER)를 암호화하는 뉴클레오티드 서열.
NCBI 기준 서열: NC_000006.11
>gi|224589818:152011631-152424409 호모 사피엔스 염색체 6, GRCh37.p10 1차 집합
서열번호 42:
호모 사피엔스 에스트로겐 수용체(ER)의 아미노산 서열.
>ENST00000206249_6
서열번호 43:
호모 사피엔스 예정 사멸 리간드 1(PD-L1)을 암호화하는 뉴클레오티드 서열.
NCBI 기준 서열: NC_000009.11
>gi|224589821:5450503-5470567 호모 사피엔스 염색체 9, GRCh37.p10 1차 집합
서열번호 44:
호모 사피엔스 예정 사멸 리간드 1(PD-L1)을 암호화하는 뉴클레오티드 서열 (CD274), 전사 변이체 1, mRNA
NCBI 기준 서열: NM_014143.3
>gi|292658763|ref|NM_014143.3| 호모 사피엔스 CD274 분자 (CD274), 전사 변이체 1, mRNA
서열번호 45:
호모 사피엔스 예정 사멸 리간드 1(PD-L1) (예정 세포 사멸 1 리간드 1 이소폼 a 전구체 [호모 사피엔스])의 아미노산 서열
NCBI 기준 서열: NP_054862.1
>gi|7661534|ref|NP_054862.1| 예정 세포 사멸 1 리간드 1 이소폼 a 전구체 [호모 사피엔스]
서열번호 46:
호모 사피엔스 예정 사멸 리간드 1(PD-L1)을 암호화하는 뉴클레오티드 서열 (CD274), 전사 변이체 2, mRNA
NCBI 기준 서열: NM_001267706.1
>gi|390979638|ref|NM_001267706.1| 호모 사피엔스 CD274 분자 (CD274), 전사 변이체 2, mRNA
서열번호 47:
호모 사피엔스 예정 사멸 리간드 1(PD-L1) (예정 세포 사멸 1 리간드 1 이소폼 b 전구체 [호모 사피엔스])의 아미노산 서열
NCBI 기준 서열: NP_001254635.1
>gi|390979639|ref|NP_001254635.1| 예정 세포 사멸 1 리간드 1 이소폼 b 전구체 [호모 사피엔스]
서열번호 48:
호모 사피엔스 예정 사멸 리간드 1(PD-L1)을 암호화하는 뉴클레오티드 서열(호모 사피엔스 CD274 분자 (CD274), 전사 변이체 3, 비-암호화 RNA)
NCBI 기준 서열: NR_052005.1
>gi|390979640|ref|NM_052005.1| 호모 사피엔스 CD274 분자 (CD274), 전사 변이체 3, 비-암호화 RNA
서열번호 49:
호모 사피엔스 인터페론 감마를 암호화하는 뉴클레오티드 서열(호모 사피엔스 염색체 12, GRCh37.p10 1차 집합)
NCBI 기준 서열: NC_000012.11
>gi|224589803:c68553521-68548550 호모 사피엔스 염색체 12, GRCh37.p10 1차 집합.
서열번호 50:
호모 사피엔스 인터페론 감마를 암호화하는 뉴클레오티드 서열, mRNA
NCBI 기준 서열: NM_000619.2
>gi|56786137|ref|NM_000619.2| 호모 사피엔스 인터페론, 감마(IFNG), mRNA
서열번호 51:
호모 사피엔스 인터페론 감마, 인터페론 감마 전구체 [호모 사피엔스]의 아미노산 서열
NCBI 기준 서열: NP_000610.2
>gi|56786138|ref|NP_000610.2| 인터페론 감마 전구체 [호모 사피엔스]
본원에 인용된 모든 참조문헌은 전체로 참고로 인용된다. 본 발명을 충분히 기술하였지만, 당해 분야에 숙련된 자라면 본 발명이, 본 발명의 진의 또는 범위 또는 그의 임의의 태양에 영향을 미치지 않고 광범위하고 동등한 범위의 조건, 파라미터 등 내에서 시행될 수 있음을 이해할 것이다.
SEQUENCE LISTING <110> F. Hoffmann-La Roche AG <120> Identification of patients in need of PD-L1 inhibitor cotherapy <130> U2912 PCT S3 <140> PCT/EP2013/075162 <141> 2013-11-29 <150> EP 12195182.6 <151> 2012-11-30 <150> EP 12196177.5 <151> 2012-12-07 <160> 51 <170> BiSSAP 1.2 <210> 1 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> HVR-H1 sequence <220> <221> VARIANT <222> 6 <223> Xaa is D or G <400> 1 Gly Phe Thr Phe Ser Xaa Ser Trp Ile His 1 5 10 <210> 2 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> HVR-H2 sequence <220> <221> VARIANT <222> 4 <223> Xaa is S or L <220> <221> VARIANT <222> 10 <223> Xaa is T or S <400> 2 Ala Trp Ile Xaa Pro Tyr Gly Gly Ser Xaa Tyr Tyr Ala Asp Ser Val 1 5 10 15 Lys Gly <210> 3 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> HVR-H3 sequence <400> 3 Arg His Trp Pro Gly Gly Phe Asp Tyr 1 5 <210> 4 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> HC-FR1 sequence <400> 4 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser 20 25 <210> 5 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> HC-FR2 sequence <400> 5 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 1 5 10 <210> 6 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> HC-FR3 sequence <400> 6 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 <210> 7 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> HC-FR4 sequence <400> 7 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 1 5 10 <210> 8 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> HVR-L1 sequence <220> <221> VARIANT <222> 5 <223> Xaa is D or V <220> <221> VARIANT <222> 6 <223> Xaa is V or I <220> <221> VARIANT <222> 7 <223> Xaa is S or N <220> <221> VARIANT <222> 9 <223> Xaa is A or F <220> <221> VARIANT <222> 10 <223> Xaa is V or L <400> 8 Arg Ala Ser Gln Xaa Xaa Xaa Thr Xaa Xaa Ala 1 5 10 <210> 9 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> HVR-L2 sequence <220> <221> VARIANT <222> 4 <223> Xaa is F or T <220> <221> VARIANT <222> 6 <223> Xaa is Y or A <400> 9 Ser Ala Ser Xaa Leu Xaa Ser 1 5 <210> 10 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> HVR-L3 sequence <220> <221> VARIANT <222> 3 <223> Xaa is Y, G, F or S <220> <221> VARIANT <222> 4 <223> Xaa is L, Y, F or W <220> <221> VARIANT <222> 5 <223> Xaa is Y, N, A, T, G, F or I <220> <221> VARIANT <222> 6 <223> Xaa is H, V, P, T or I <220> <221> VARIANT <222> 8 <223> Xaa is A, W, R, P or T <400> 10 Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 1 5 <210> 11 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> LC-FR1 sequence <400> 11 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 <210> 12 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> LC-FR2 sequence <400> 12 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 <210> 13 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> LC-FR3 sequence <400> 13 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 <210> 14 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> LC-FR4 sequence <400> 14 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 1 5 10 <210> 15 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> heavy chain <400> 15 Gly Phe Thr Phe Ser Asp Ser Trp Ile His 1 5 10 <210> 16 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> heavy chain <400> 16 Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 1 5 10 15 Lys Gly <210> 17 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> light chain <400> 17 Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 1 5 10 <210> 18 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> light chain <400> 18 Ser Ala Ser Phe Leu Tyr Ser 1 5 <210> 19 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> light chain <400> 19 Gln Gln Tyr Leu Tyr His Pro Ala Thr 1 5 <210> 20 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> heavy chain <400> 20 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 20 25 30 Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ala 115 <210> 21 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> light chain <400> 21 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 22 <211> 195 <212> PRT <213> Homo sapiens <400> 22 Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 1 5 10 15 Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 20 25 30 Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 35 40 45 Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 50 55 60 Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 65 70 75 80 Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 85 90 95 Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 100 105 110 Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 115 120 125 Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 130 135 140 Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 145 150 155 160 Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 165 170 175 Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 180 185 190 Leu Thr Arg 195 <210> 23 <211> 124 <212> PRT <213> Homo sapiens <400> 23 Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr 1 5 10 15 Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His 20 25 30 Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly Ile Cys Glu 35 40 45 Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser 50 55 60 Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr 65 70 75 80 Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu 85 90 95 Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln 100 105 110 Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val 115 120 <210> 24 <211> 169 <212> PRT <213> Homo sapiens <400> 24 Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr 1 5 10 15 Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser 20 25 30 Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr 35 40 45 Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu 50 55 60 Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp 65 70 75 80 Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His 85 90 95 Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu 100 105 110 Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 115 120 125 His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu 130 135 140 Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu 145 150 155 160 Asp Glu Cys Val Gly Glu Gly Leu Ala 165 <210> 25 <211> 142 <212> PRT <213> Homo sapiens <400> 25 Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 1 5 10 15 Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 20 25 30 Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 35 40 45 His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 50 55 60 Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 65 70 75 80 Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 85 90 95 Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 100 105 110 Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 115 120 125 Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr 130 135 140 <210> 26 <211> 107 <212> PRT <213> Mus musculus <400> 26 Asp Thr Val Met Thr Gln Ser His Lys Ile Met Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 20 25 30 Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 65 70 75 80 Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 27 <211> 119 <212> PRT <213> Mus musculus <400> 27 Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 1 5 10 15 Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Thr Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 35 40 45 Gly Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 50 55 60 Lys Gly Lys Ala Ser Leu Thr Val Asp Arg Ser Ser Arg Ile Val Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Thr Phe Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Thr Leu Thr Val Ser Ser 115 <210> 28 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> Humanized 574 Variable Light Chain <400> 28 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 29 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Humanized 574 Variable Heavy Chain <400> 29 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 50 55 60 Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 30 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> Consensus framework Hum kappa1 Variable Light Chain <400> 30 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 31 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Consensus framework Hum kappa1 Variable Heavy Chain <400> 31 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Val Gly Tyr Ser Leu Tyr Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 32 <211> 214 <212> PRT <213> Artificial Sequence <220> <223> Pertuzumab light chain <400> 32 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 33 <211> 448 <212> PRT <213> Artificial Sequence <220> <223> Pertuzumab heavy chain <400> 33 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 50 55 60 Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 34 <211> 214 <212> PRT <213> Artificial Sequence <220> <223> Trastuzumab light chain <400> 34 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 35 <211> 449 <212> PRT <213> Artificial Sequence <220> <223> Trastuzumab heavy chain <400> 35 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 36 <211> 217 <212> PRT <213> Artificial Sequence <220> <223> variant Pertuzumab light chain sequence <400> 36 Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 1 5 10 15 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val 20 25 30 Ser Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 35 40 45 Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg 50 55 60 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 65 70 75 80 Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile 85 90 95 Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 37 <211> 449 <212> PRT <213> Artificial Sequence <220> <223> variant Pertuzumab heavy chain sequence <400> 37 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 50 55 60 Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Lys <210> 38 <211> 100190 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..100190 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 38 agtccacagc tgtcactaat cggggtaagc cttgttgtat ttgtgcgtgt gggtggcatt 60 ctcaatgaga actagcttca cttgtcattt gagtgaaatc tacaacccga ggcggctagt 120 gctcccgcac tactgggatc tgagatcttc ggagatgact gtcgcccgca gtacggagcc 180 agcagaagtc cgacccttcc tgggaatggg ctgtaccgag aggtccgact agccccaggg 240 ttttagtgag ggggcagtgg aactcagcga gggactgaga gcttcacagc atgcacgagt 300 ttgatgccag agaaaaagtc gggagataaa ggagccgcgt gtcactaaat tgccgtcgca 360 gccgcagcca ctcaagtgcc ggacttgtga gtactctgcg tctccagtcc tcggacagaa 420 gttggagaac tctcttggag aactccccga gttaggagac gagatctcct aacaattact 480 actttttctt gcgctcccca cttgccgctc gctgggacaa acgacagcca cagttcccct 540 gacgacagga tggaggccaa gggcaggagc tgaccagcgc cgccctcccc cgcccccgac 600 ccaggaggtg gagatccctc cggtccagcc acattcaaca cccactttct cctccctctg 660 cccctatatt cccgaaaccc cctcctcctt cccttttccc tcctcctgga gacgggggag 720 gagaaaaggg gagtccagtc gtcatgactg agctgaaggc aaagggtccc cgggctcccc 780 acgtggcggg cggcccgccc tcccccgagg tcggatcccc actgctgtgt cgcccagccg 840 caggtccgtt cccggggagc cagacctcgg acaccttgcc tgaagtttcg gccataccta 900 tctccctgga cgggctactc ttccctcggc cctgccaggg acaggacccc tccgacgaaa 960 agacgcagga ccagcagtcg ctgtcggacg tggagggcgc atattccaga gctgaagcta 1020 caaggggtgc tggaggcagc agttctagtc ccccagaaaa ggacagcgga ctgctggaca 1080 gtgtcttgga cactctgttg gcgccctcag gtcccgggca gagccaaccc agccctcccg 1140 cctgcgaggt caccagctct tggtgcctgt ttggccccga acttcccgaa gatccaccgg 1200 ctgcccccgc cacccagcgg gtgttgtccc cgctcatgag ccggtccggg tgcaaggttg 1260 gagacagctc cgggacggca gctgcccata aagtgctgcc ccggggcctg tcaccagccc 1320 ggcagctgct gctcccggcc tctgagagcc ctcactggtc cggggcccca gtgaagccgt 1380 ctccgcaggc cgctgcggtg gaggttgagg aggaggatgg ctctgagtcc gaggagtctg 1440 cgggtccgct tctgaagggc aaacctcggg ctctgggtgg cgcggcggct ggaggaggag 1500 ccgcggctgt cccgccgggg gcggcagcag gaggcgtcgc cctggtcccc aaggaagatt 1560 cccgcttctc agcgcccagg gtcgccctgg tggagcagga cgcgccgatg gcgcccgggc 1620 gctccccgct ggccaccacg gtgatggatt tcatccacgt gcctatcctg cctctcaatc 1680 acgccttatt ggcagcccgc actcggcagc tgctggaaga cgaaagttac gacggcgggg 1740 ccggggctgc cagcgccttt gccccgccgc ggagttcacc ctgtgcctcg tccaccccgg 1800 tcgctgtagg cgacttcccc gactgcgcgt acccgcccga cgccgagccc aaggacgacg 1860 cgtaccctct ctatagcgac ttccagccgc ccgctctaaa gataaaggag gaggaggaag 1920 gcgcggaggc ctccgcgcgc tccccgcgtt cctaccttgt ggccggtgcc aaccccgcag 1980 ccttcccgga tttcccgttg gggccaccgc ccccgctgcc gccgcgagcg accccatcca 2040 gacccgggga agcggcggtg acggccgcac ccgccagtgc ctcagtctcg tctgcgtcct 2100 cctcggggtc gaccctggag tgcatcctgt acaaagcgga gggcgcgccg ccccagcagg 2160 gcccgttcgc gccgccgccc tgcaaggcgc cgggcgcgag cggctgcctg ctcccgcggg 2220 acggcctgcc ctccacctcc gcctctgccg ccgccgccgg ggcggccccc gcgctctacc 2280 ctgcactcgg cctcaacggg ctcccgcagc tcggctacca ggccgccgtg ctcaaggagg 2340 gcctgccgca ggtctacccg ccctatctca actacctgag gtgagggccc gggacggggc 2400 acgcccagcg cgtccgggag tagcggttcc gttggcggcg gcggccgcca accctcagcc 2460 ccagccccag cgcaccgctg cgctccccgg ggcggccgga gagggtgggc agcgggacac 2520 agcacagggg cagttgcctc ccttcttctt ccctcctctc ctcactcttg gggacacgaa 2580 ggtgggcgca gaatatacta tttttggggc gtgcctccct gaaagctgtt tttttgtttg 2640 ttttttaact ttccgaatct tccagattcc gaagcagaac caaccccgat ttaaaacgtg 2700 cagcgtcaca ctaggtccgc tgtagcccag tggggcagaa agtgcgcggc gagttggggg 2760 ctttatgaaa tgcttctttc ttagaagaag gacgtttacc aggagtgctt gtcttggaga 2820 ggagttaagg caccgttccc ccgggagggg tgggacttga gaggtggccg gccagaaccg 2880 aaagcagcac catcttaggg atttgaacac ttcagtggct cagttttctt aagaatctca 2940 agattaaaat taagttcacg tgggaaatgt ttaaactgtg gatttaaacg cctgtcactg 3000 cattgcaccg ttttcttatt attgcttgct attcactaca atttttttta tatacaggtt 3060 taaaaaacac tactttgcat actgaagtaa tggaatgtaa aaaaagaatg ctctgtttgg 3120 aatcttatgt tgtgaatagg caaaacagtg tcagtgtatt ggacaatact ttaaaatgac 3180 aaacatatac ttgcttaagt aagcaatgat tacagggttg tgttttaaaa actcaaaacc 3240 aaaacattgc aaagtaccat cgaactttta aagccaaacc atatttgttt tgacccagca 3300 tacagacagg aaggacataa catttcattt gtcaaagact aaattgtttc tatataaaga 3360 gttttgtaga aagatttcct tttaaccgac tttaactttc taggacataa tattatacac 3420 taattattgt tcttttatat tggtgctact gatgaatggc taatcatttg caagtatggt 3480 gaatccagtt acggatagtc tattaccaag tttagtttgc atgtctttca agtgtatata 3540 tacagttctg tttttaaaat ctcctttcac cctgttaata ctggtttaag aaacctttag 3600 tattagatag tggtgcactt aaaaataaat ggagtacttt gttttgcatt tcaaggccgg 3660 attcagaagc cagccagagc ccacaataca gcttcgagtc attacctcag aagatttgtt 3720 taatctgtgg ggatgaagca tcaggctgtc attatggtgt ccttacctgt gggagctgta 3780 aggtcttctt taagagggca atggaaggta ggctcctttc ccctgatcct ttattattgg 3840 tttaattgta aatggagacc atctaatatt gtatagattt caattattcc ttgtttctta 3900 taagaaatgg tgatatttcc atataattta aaatatatga tgacatttta acaatatgtt 3960 tttatttatg atactcaaaa tggaatgtgg ttgggtacta taattgcata ctctttgact 4020 aacactttca gtattagaca taagtcataa aaatcttgag gacagtgcta ctattgttcc 4080 ttaactgctt agctttgagg aaacagcttt gttctaatag tacttttata tatctattat 4140 gtaggtatat gtgtatgcag tactttaaaa ttttgattaa aagaaaaatg gtagttgaca 4200 catatgtaca tgtatgcgta tacatatttg tacatacacg aacatatatc acaacatgta 4260 tatgatgcag ttttctacat gatactgtct tttgactaca tgaatattta tgtaatattt 4320 acaaagaagt aattctaaac aaatttttga attctctttt tgttcagtat atttttgtaa 4380 gtgtataaga ggacaggatt aaacagttta aaataaaaaa cctggacatc acagtaacat 4440 aatttctaaa gaagtatttt gctttaagta aaactttcat gtttttaaac tcattgaact 4500 tacatgctta atgatttcag atttacttgc atagtgtttc agattttaac tttcaaagaa 4560 aatatttttg aatttctttc tacctaaagt ctaagcagcc aaacatcttt acatttgaag 4620 ataaaaatac attgaaagat ttcatatttt aataccagca ataaatgtat tctataacta 4680 tgtaaaatga agcttaggat tccctctgga gtgctgagat cacacctaga caaggaacca 4740 aggatctgaa tgttggcttt ttgtttcctg ttctgaggat ttttgtttgt ttgtttgttt 4800 caacagccct ctccttacaa gcagaaaagc aggtagtagg aaatttcact ttaagggagc 4860 tttcaaagga gttcttcata acaaatattt gctttgtata tttttagaac atgatttttt 4920 ctcacaaaag atgaatgtat tttactgatg ttgaacatat tcagctttag ggggtttgat 4980 tgcattttaa actaattgag gcagtgttaa aagtggtact tgagaaaata gggcaactga 5040 tagtggctct tacccattga cattatttat ttacagttac agttggaagt tctttgtgtg 5100 gaaaagtcag ttttccaatg ggtaattgga gttaccattt ttatctgact ttggttctgg 5160 tttcttaaac attgccttct gcattaatat gatttcctct cttcttaaag tctcctaagg 5220 atagtataat tttataagtg aatgactccc ttagaatcct cttaagccca atttgtccta 5280 ccccagctcc ttcttttgaa agataagcaa atctcaaaga cataaatatg agtttccaaa 5340 ggtcacaaaa ctagttagta gctgattgtt agtaaacata ggttaaatat ttttacattg 5400 cagcgcttgt aaatcagaga tgatatgcaa aagtagatat ataaactgtt tgattcacag 5460 aagttatttc ataaagtgca tatatagaac aaagagcacc ctaactaaaa tacaaatgct 5520 ttctcgtcat tttgttagaa tagcatccaa aactgtagac gaagtctttc caaatgtact 5580 cttagaaagc atttgttgga ctccggctgt tggcatggtc ctatagtctt gagtactaga 5640 agtgaagcac ctttatttag cagtaattac aaagagttac ttaagattga tgcagataaa 5700 tcattcatga aactagaaca agattatgaa ctacattagt aagttccttc attcagcaat 5760 ttatgccaaa gatacacttt ccctgacttc acttttctct gccttgagat aaaatgagga 5820 taacagtggc tatttcttag ggttgctata aagattaaat gagctgatac ttgtaaagta 5880 tgtaaaagaa ggcctgacat attatcagtt tccattgaca tttctacttt caaggaactt 5940 gtaatatagt tagggaggta acatatgcac ataaaacatc taaataaaga ttctcagtaa 6000 atgcccaagt aagcaattct gtaatgtata tgagatctgt gtggtttgtg agtttttgta 6060 tttggacaga gcgaggtggt tatgggttga aatatgtata ttcttgaatg atgaagaagt 6120 ctacatggaa gatatgaaca tttgattagt aaaggacaaa taagctttct aggcattgag 6180 gagagcttta agtgtataca gtcaaagaag agtgaagaaa ttaagattac actgactaag 6240 cattgaatgt tcacattagg aaattgagag agttaaagtt tgagaaacta gattgctagt 6300 gtttgggtga atttggagaa tcggtaattt aaggcaagag aatatagaga atgttctagg 6360 agttttcagg aatgagaaag ataagtagaa ggacttatat caggttcaaa atcttcaata 6420 aagcaatgct gcgtgatgag ctggttcaag gtggcgctgt gtgtggatgc caatatggcc 6480 agaagtttaa agtaaacagg caacaatatg gatactaatg ttgccaagga tgagaatgaa 6540 aatgatggca ttataaaatg ctttctctgt gccagtgact atttcagtgc tttgcaggtc 6600 ttaacttatt tagttgttat aatgttggta ttattattat tactcccact ttacaaatga 6660 ggaaactaag acctgtagat gttaagctgt cttaatacgc ttaggaaatg gtaaagtcag 6720 gattcaaatc caggtggtat gaatccagaa tcccggccct tgaccactgt gcttcctttc 6780 tcataatagg aaatgcagtc aaagaaaaac aatagagggt tagaagaaaa gatgtgagcc 6840 aagtgatgaa acatctagga aggtaaaagt gaatcctaaa ggagaatgca agagcagggg 6900 taatgagaag tgtgtgatat aaaaggatgg atcatattaa cttcacattt agggcagcaa 6960 taagaagaca taagcaggag ccaacagcca gtttcttcac ctccctccca tgttaggaga 7020 gggaggtgat aaagcctata aagtcattct ggatgactgg gtttccctgg atatgagaca 7080 gaagagagaa gagataaaga aataagatac cactcaggaa atgggagaaa ggagttggga 7140 aaaatgattt cttttaagct aattgaactg tttaggatat agtattggcc aaaaaccagt 7200 tggttggata gcccattgca ttcctttacc aagacttgta ggtttggagt gaaccatgaa 7260 aggaccagga attgacttaa tgccttccaa agagaggaag taatcatgac ctgccagtcc 7320 tacaaatgca gactactaac ctggtatgat gaaggaaagg actatttctc aatggcttat 7380 ctttgccagt acacagtaac cagcccagtg ctaggaatat actaggcatc cagtagataa 7440 ctgctacatg atccagtcat cataactgat aacgccacac ttttattttt tggatgcttt 7500 actcagtgac agcatttgtt gtgaatacat ttggtgtaat atcattaaac acatgttata 7560 atacaattga aatgtattac ttagaagaca ctaagctaag taggtattga aggattttca 7620 attgtattgc atattatgct cacttttttt tttttttttt tgagacggag tctcgctgtt 7680 gcccatgctg gagtgcagtg gtgtgatctc ggctcactgc aagctccgcc tcccgggttc 7740 atgccattct cctgccttag cctcccgagt agctgggact acgggtgccc cccaccacgc 7800 ctggctaatt ttttgtattt tttagtagag atggggtttc accatggtct caatctccta 7860 acctcatgat ccgcctgcct cggcctccca aagtgctggg attacaggcg tgagccacca 7920 cacctggcct gtcctcattc ttttattcat atattaattg ttcatgaagt aattacctta 7980 attacattag ttcatgtatt tattgagtac ctgccatgcg ccaggcacta tgttaggtac 8040 tggtgaaacc acagtaaaac gagagacctt gctggctgtt gactaaagtt tatagtgtgg 8100 tggtggagag agacatttta cctatttgtg tacacatgac taattgcaca tgtggtaagt 8160 gattcgttta tgcaatgttt ggacaactag agaattgacc cctctgtcag ataatgggga 8220 aagtttttca gacctagaca tcacaataaa tagactgcag aggaaactag acagaaatga 8280 aatactttta tgaataaagt gtttctttca aaagttgggt atacttggtg tcataggcta 8340 gtaatgaaaa ctggtttggt agcatagttc tccttgatac agcatcagaa agagaaagat 8400 tgaacatcca atttttcatc agcaacttct gtgatttatt tgttctatat ttagagctct 8460 gtaatgcttt ctccatcttt tgtagtgcac agatcatcca gcaatctctt ctactataat 8520 ctatttgaat ttgaataata tttgggctct gagaagatat tttgccaata atcttattta 8580 tattcattta atctccaata gagtctgctc tatagcagct ttcacattac cctaaaaata 8640 aatatgtagt aattcactag attttatttc aaaactctat atccaatttc ttttcaagct 8700 gaggtctctc agtttactat ttagcatgga taatgataga ctggttttaa gcaccacttt 8760 acattagggt tcattgaaat ctctactgta ctgaaaaaga aatggttaaa aagatagcat 8820 ttggtgtcat ctgttcatat ttggttattt agagctccca gatttttaat actctttcag 8880 aacatgtact ttaataccac tacaagagcc agaggagaag cagtggtatt agccatgcgt 8940 gctagtgcta ataactgctc ctgttctggc cactgaatca ttgtacttta attactcaag 9000 taacacaaaa atccatctcc tttaaaaaat gaaaatgtta tcaataaggc ttaagtcctc 9060 ttgatcaata cctctaatct gttcccttgc ctaccatctt tctatacctc tacctcagtt 9120 tttcccatgt gtatgtgtgt gtggaatatg ttctctgggg tatgttaata tataaatggt 9180 attatatatc ataatttatg catcatgtta ttttgataca aaaatgactt gaagctctat 9240 tgttcatata tgtagttcca acttgttttt ttaaccactg cttaatattt cataatatga 9300 aaaatcatta tatttaggaa ttactaatta cactattact tgagtaaacc ctttttgtac 9360 atttctcctt tggtacatgt cttgcttctc tttccagaat atattgaagt attttgatac 9420 agttctaaat gaactagatg attagctttc tacctgctgc taagatgatt tgattcacta 9480 atttattcac ttcagataca tgtattgatc ctacatttaa aagttgcttg tgctgggact 9540 gaagatgaaa atgtatgcag accctgtctt tgacatgcac aaaaccaaga agaagaaaac 9600 aaaacagaac aaacctgtgg tacaactagt gaacatgaga ataccttgat acaagttatg 9660 ccagagccgt ggccaacaca ccgtagtatt cagttagaca catggagaag aatggcagtt 9720 tattctgcta acatatcttg atgttgtgca agaggcttat tcatttaata gtcacttaag 9780 tcgccttcac tataacccag gcactgtttt aactgcttca ctggattagc tcaattaatc 9840 cttgtaagag tcctttgagg tggaggttct gttagtatct atattttaca gatgggtgta 9900 aagagaggtt tctactattc aggaggtctg actctaactt ctgtatctta aattcctgct 9960 tctgtgctgt tttcctagac tgttttgtat ttgagcaaat attaattact ttatactttt 10020 tcagataaat acatggtctc ttataggaga ctggttttca aattgtgctc cttaactcag 10080 tcaagttcct tcttctattc agaacagctc tgtatttctt tatttggttt atatttccac 10140 ttgagatttt tattgggaca aaggattctc agccaacctt tttttaaaaa gcactccttt 10200 ataacaggaa acccttagat ctcaatcaag tatttattcg agtgactcct aagaagtttt 10260 ttggctctat ttgctggtat ctttttggca tttgtgcaaa gacgagatga ccatttgtga 10320 tcaagattta aagtccaact gctcactctt ctaacagcat ggccacatta ttagccgaaa 10380 atcacatctg agttatagag cttttgcttt tgtcagaaaa aaaacaaagt aactccaggg 10440 aatcttttat cagtcacttc tttaaaggat tgattgaaat aattgacact taagacagac 10500 actcaaaaat aggcacacta atcatttaca caagggattt ccaaccccta ggatgtggac 10560 tggtaccaca gccagtccat ggtccggtgc gggcccatgg cctgttagga agtgggccac 10620 aaagcaggag gtgagcagtg gccaagcgag aattacagac tgagctccgc ctccctgtca 10680 catcagcagc agccttagat tctcataaga gtgagaaccc tattgtgaat tctgcatgca 10740 agggatctag gttgcgcact tcttatgaga atctaatacc tgatgatctg tggtagaaca 10800 atttcatcca gaaaccatcc cacaccatcc atggaaaaat tgtattccac aaaactggtc 10860 cctgatacca aaaaggttga ggactgctgg tttacatctt ggtttttaaa ctccattgtc 10920 atttaagaac atcagaaagt cacatactct gtatatcttc cctatctacc taatttgagg 10980 agaggccgat gaacacaata tccttcttgt ggctagatgg ccctcatata attaactata 11040 taatgcatac ttcatataat ctatcatcaa gacatttttt tctcctctga tgagatatta 11100 tgctttttaa taagtgatat gtaaatagcc tattgggttt tcctttttat tttaactcct 11160 gcaaaacaag tacattttaa tgctcaattt taaaaaatta acaggttttg agctttattt 11220 ttaactgcta ctacagcgtc ttgtgttgtg tactttatat gacattttaa ggaatcataa 11280 cttttttctt aaagcatagt atttactagt aatcattatt tctttaggaa aaaaatgcaa 11340 atacttttca tgctatttac tcttctataa ccaagtgatt tatttatgag atagaataca 11400 catgtagtga gtatggaccg tgagctcaaa acagtgctgt agcatttgta cgaaatataa 11460 aaattaaagg gtaaaaataa tggttatcat ttattgagtg tttactaaat tcaggtactc 11520 ttctaatgtc tctttgttta ctaactcatt taactcttgc aacaaaccta tgagacaggt 11580 tctatttttc tcattttaca gataagattt gttcagttag tcaacagtag agcagaactc 11640 cactcctgga gtcaatgccc ttaacttcca ctggatattc ctttgcagga aaagatacag 11700 tctttgattt caaggagcct gcagtgtgtg tgtggaagtg agtgattaac agacaacact 11760 gcaaatttag tgtttgatta aattgtgtgt tgcagactta gggtgctata agtgaactag 11820 agaggaaagt accaagagtt gtcattactg attgcctata tataatagaa accatgctaa 11880 atgctttata tttaatattt ctattcttca caacaatcct aaaaagtaga atttaccatt 11940 tccacttcat atgtaagcaa agactcagaa gttagttaac ttaccccaat taatagtagt 12000 actggcagag atgtgtctgc agtagttaga aaaggtagtt tattgagcta gtaagattta 12060 ttcaaagcct ttaaaaacag agacagtaat taagaaacgt ttatttttga tagttttttt 12120 aatataataa tattgtgact cctggcgtat tatacacaag aaaaatttca ggtgggtcaa 12180 caacttaatt ttttttttat ttgaagaaaa gaaacctaaa agtatggaaa gatgatggag 12240 gtatgtattt atagtcttgg gatggaaaac tttctaaatt tgatataaaa tccagaattc 12300 aaaaacaaat ttgctccatt tgctatgtaa tctcaaattt cttatataag gcaaaaaatt 12360 cataaagtca aagacaacaa caaattagga aactgtaaca tatatgtaaa tcaaaaggaa 12420 attattaccc atatacaaaa tattcttaca aatcaagaaa aagacaaaca ggaagaaaaa 12480 tgaacaaaaa atattaagac agttcacaaa gtacagccca cagaagtatg aagaaggctc 12540 aactcactaa taagcattac tgattaaaat aataatggga atttcagcaa tttgagtact 12600 ggaataataa tgaataacaa ataatgacca ttggagaatc tgaagatagt ttggtattgt 12660 caattaaaat atgcgttact ttggcccaac aattctactt ctagaaactc atccttacag 12720 aactctagaa tacctgtagg tggatgttta ttgcagtatt acattattta taatactgag 12780 aaactgaata cagcccaaat gtctgttaaa aagagattag caaattgtgg tatacccttg 12840 caatgaaaag agtgagttag ctgtctatac tacagatgtc aagaagtctc taaaatattt 12900 gattttatga aaaagcaagg aacaatatca ttctgggtaa aaaattgtac ccatttgatc 12960 ttgctaggta tagagagcta tctaaaagaa aataactaag tgcttactgt caggatgaga 13020 gacttccaat ttctgatgac atgttttggt cttttttttt tttttttttt ttttgaggtg 13080 gaatctagct ctgtcaccca gcctggagtg cagtggtttg acctcagctc actgcaacct 13140 gtgcctccct ggttcaagtg attctcctgc ctcagcctcc cgaatagctg ggattacagg 13200 tgcccaccac catgcccagc taattttttt atttttagta gagacagggt ttcaccgtgt 13260 tgaccagatt ggtctcgaac tcctgacctc aggtgatcct cccgccttgg cctcccaaag 13320 tgttgggatt acaggcatga gccactgcac ccagcttcat tctttaagca agtatttact 13380 gaaggggctg caattacaca ccaacttggt gcctgacttt cctccacact ggccccgcct 13440 agtctcagct agcctctgct gccctaatgg tgtccagtga ccatatgtgc cacttttcac 13500 cttcaggtac cctagaatgt tgaaagagac taacaaagaa tgaaacttga agaatattga 13560 agcaaaagct tgaggttact ctgtatcatg aattaaggaa tccttcctga ctagatggag 13620 ccaagaatgg acacaggccc acaattcctc acacacaatc tcaatattca aaaagcactg 13680 caaacaaaaa ttttgttgta gtcacttgtc aacaatacct aacctgacgt gaatttgttt 13740 ggcagcaaaa tctgatctga aatcacatga ggaaatcttg tagtctatgt aaatattcgt 13800 acattttgct gcataaatat aatgttttat taagtgttgc tctattttat ctttctaaaa 13860 tacaaacaat tttgaatttt gaaacacaat tggcccaata catttcagct aagagatttt 13920 ggacatgtac tcagaaatga tttatagact atgttgagag tggtgcctgc tggctttttg 13980 caatgtagca gccctgaaaa tttttataaa caattcttat catttattct tatctttttt 14040 ttttgagagg gagtccccgc tctgtagccc aggctgaagt gcagtggcac aatctcagct 14100 cactgcactc tgcctcctgg gttcaagcga ttctcctgcc tcagcctccc gagtagctgg 14160 gattacaggc atgtaccacc acacacacta atttttgtag ttttagtaga gatggggttt 14220 caccatgttg gccaggttgc tcttgaactc ctgacctgaa gtgatcctcc caccttggca 14280 tcccaaagtg ctgggattac aggcgtgagc aacagcgccc agcctattct tatcattttt 14340 aataaattct tagtaccatg ctgggttcta cagggagcta taaaagataa ataagccata 14400 ttacctaact tcatatagtt ttcgttcaat catggagttt atcccatatt caagtataat 14460 ataggtaata tataaatcaa atgtgttttt gatttcaagg ggaaaaagat catatttagc 14520 tagggagacc aaaatgtgtt tttatggaaa ggatagcatg ctagatgggc tgctgagaat 14580 gcatgaaatt tttgatagca agaattgtaa tggcttttgt aaacaaaaac tacagactga 14640 gcagaaggac aatttggcta aagcatggaa catggtcaga atcccttacg attatatata 14700 aattatttgt gttttttcta ggataattct tttcatgagg ttttgaaaga gatcagtgac 14760 cccttattcc cacccccaaa aaagttagct taccactgct ttaaaggaat ggtgaggatt 14820 attataaaac agaaggtcaa gaaaatgtgg aatgcacaat ggggtgttta caattaattg 14880 agtaaagagt gagaagcccc taaatatttt ttgggcagtg tagtggcata ttttaatatt 14940 taagaaaatt agtatatcag cagtatattg gaaagattaa tgtcagaaag gtaagggaca 15000 aggaaaacag tctggggatg gtgcactaag gacctgagcc agggttgtgg agagaggaat 15060 gggttcaatg ggtagattgg aaccaattga gaagggtgat gaaagcgaca cagagaattg 15120 tgggggtggg ggacgtcacc ttcagaaata ggaagtacat gatcatttta ctcagtaaag 15180 gagtgatgtt gaaagtagta tttaggaagg attatcctaa aagcaccatg cagaatatat 15240 ttgtacagag attagatagc ttgaagtcag agagaacagc taggaaactg gtaacacaga 15300 ttctgagaag tagtttaatt tcaaattgtt tgtattatat tctacataat gtcctcagca 15360 ggatattgaa ataatataat ttttgtgcac aaaataactt atgagaattg agatgttctg 15420 gtttgtcact tcatttagtc gtctgcttat ttattaattt ataccaaaaa taatgccgtt 15480 ttgtgcctgg atttgtgtta aatattgaga ctcaaaaatg gatgagccaa gttcataact 15540 taggagaaag gcacataaac acgttgcaga aatgcagtct ggtaatatct atgagaggtg 15600 tgagctgaga attgtggaag tataggacag gaagatctaa ccctggtgtt taaatgcggg 15660 gtatggaagg agaaagtctg aatcctgact aagtattaga ctaaaaatat taaatcttaa 15720 aaattattgt aatttcaaag tttgtggcaa cttttttgta attaacagtg gagaccacaa 15780 tggtttatct tctttaagca gagcacttca gtgagtgttt ctttgtgcaa aggcccatcc 15840 agaggccact ttggatgggg gggcggatga aagtatgaag aactgaacct ctctatgtac 15900 tattttaata gaaattaggg aattgtaggc tagcagctgg ggcaaggagt aggaaataga 15960 aagggcctaa caactgagta ggaagcaagg gctcaaggag agtagatgcc tgtgagaatt 16020 tccctattgc aggcaacaat ccataaatcc ctaggctggt agtgcctgat agcaaacttg 16080 gaattgttta ctatctcatg ttttaattac ctccagctac ctcccaaccc ttaagtaaat 16140 ttttgctgtt tacattttcc tttataaaag gatatgcatt tcagattgct gacctttcct 16200 atgatgacaa gtgtctcagt agtatgatac ttagaagata tataggccgg gtgcaatggc 16260 tcacgcctgt aatcccagca ctctggaagg ccgaggtggg cagatcacga ggtcaggaga 16320 tcgtgaccat cctggctaac acggtgaaag aaaccccgtc tctactaaaa atacaaaaaa 16380 aaaaaatagc caggcatggt ggtgggtgcc tgtagtccca gctactcagg aggctgaggc 16440 aggagaatgg catgaaccta ggaggtggag cttacagtga gtggagatca caccactgca 16500 ctccagcctg ggtgacagag caagactctg ggaaaaaaaa aaagaagata tttagcagaa 16560 ggtacagtta atctgcccct tcaagttaaa gataatgttc atgatagaaa aaaggaggta 16620 acttctgttt gaaagacact gttgttttgt agatagcatt ttgaaaacaa gtctttgggg 16680 atgattccac tgttatttga ttttgttgtg aaggtattat aagagatcaa aattttatag 16740 tttcatacat aaacattttg aaataagatt ttctaacttg ctaaaaaatc ttccaaaaaa 16800 attcagttag gttctgaaca catttcataa tagtggcatt tattgaacac atatgtcagg 16860 aacttggcta aatgtgttat attaaacaca aagattttaa atcacttgca cagataaata 16920 gtaaataaaa tggtagagct gagattggaa cccacagaac cttctctctt atttgttaat 16980 attacctctt attcattatc tagtgtctct ttgtcctaag tatttgtaat gaaaattgat 17040 tgacatcagg gagagtagat acttgctagc tgaatttctg gggtaaaaga agcttttcat 17100 aactggtatg tggaattgaa agtgaatatt atgactagat aatctgccct gcagacagtc 17160 ccctcattct ccatggcttc tgggatggct gtcttccacc ttctcttctc agcctgccag 17220 cactcccctg tcctcacttt cagctaacag ccttgcttcc taattttcgg aaaaaaactt 17280 tctgaaattg ctaccaccat ctgtatggac agaagtggcc tctgaactat aatcccattt 17340 ttctggggtt accagagctc tgcagttctc aagtccagcc ctctctcctt gaccactaga 17400 tccagattac tcctgctgac tcaaggacag gctctaccaa tcctcccgca acatttaaat 17460 catttttccc cttctctact ggataattcc tgtcagccta caacatgctc ttccttttct 17520 catcttaaaa tataaacaaa ctacttttgt tgatttcact tactcttcag ccaccaatca 17580 tttttcttct tttacagcaa aactcttcta acacattttc ttctcccatt cactcttaaa 17640 cctaacccaa tcagttgttg acctctgtca ctccaccaaa acttctcttg tcaaggttac 17700 catgttacta aatcttatgg gcaattgtca gtcccatgtt acttgactca ttggtagcat 17760 ttgacaattg atcactccac cttcctgcaa atactttatt cgcttggttt tcaagacacg 17820 accctctctt gattttcctc actagctccc cttcaaactg ttcttctcct ttagctttta 17880 atatgagagg gtccagtgct gagtattctg agtatttggt cctcttccct tctgtttata 17940 tacttacttc cttggttatc taatccagtc tccaaactgt ggataaacca cccaaaatcc 18000 aatcacttcc aaatttctat ctccagccca gacctttccc ctgaactcca gactgaatat 18060 ctcaaaccaa cacatcccaa agttggctcc tgatctactt agggttttct ctggtaagcc 18120 agtgttcttt tggtcctcaa gctatctgcc tcagaatcac ctgggtactg gtttgagatg 18180 atttctgcac ctcgccccag gtaagccaag tcaaaatatc taagaaaggg acccagaaat 18240 ggcatttcag ctagctgttt ggttgtttct taaagttctg cttggctcag aggggagcca 18300 gatacaaagc tgagaggtga aatggttggc tttgtttttg agaacattaa ctctagaagc 18360 aatggggaat agaggcagaa ggtcatgcca gggagatcag acctaagatt atttaaaata 18420 ctctttgatc gagatctggg ggccttcagt cttatgctga gaaaacacta cttttcattc 18480 cctaaagcag tgaacctgaa atatagaagg caggcaggct gtggccccta ccaagaatgc 18540 tcctttctct aggaagaatt ctaaaaaatg tgagaggcta gggagggagg ttggagactt 18600 ccactttttg tgtccttact atataccagg cactatagta gacacattat atgtatttgt 18660 tataggcata ccttagagat atcgcaggtt ctgttctaga caactacaat aaagcaaata 18720 ttgcaataaa gcaagtcaca caaatttttt gctttctggt atctaaaaaa gttatgttta 18780 cactatactg cagtctgtta agtgtgcagt agctttatgt ctaaataaac aatgtacata 18840 ccctgattga aaatacttta ttgctaaaat tgctaatgat cacatgagcc ttaagggagt 18900 tgtaatgttt ttgctggtag agggtcttgc cttgatgtga atggtcattg acttatcgag 18960 gtagtgattg ctggaggttg gggtgtctgt ggcaatttct ttaaataaga caacagtgaa 19020 gtttaccata tccatagact gttcctttca caaaagatta ctctgtagta tgcaatgctg 19080 tgttttaccc acagtagagc ttctttgaaa attggagtca cttttctcaa aacctgctgc 19140 tgcactatca cctaagttta tataatatcc taaatcctaa atcttttgtt gtcatttcaa 19200 caatgctcac agcgtcttca ccaggagcag attgaatctc aagaaaccgc tttctttgct 19260 catccatgag acaagacccc tcatgtgttc aaattttatg agattttagc aattcagtca 19320 catctttgaa ctccacttct aattccagtt cttttgctat tcctaccaca tatgcagtta 19380 cttcctccat gaagtcttga atccctcaaa gtcatctata agggtttgaa tcaacttctt 19440 ccaaactgct gttaatgctg atgctttgac tttctccgat taaccacaaa tgttcttaat 19500 gacatctaaa atgatgaacg ctttctaaaa gattttcaat gtactttgcc cagattcatc 19560 agaggaatta caatctatgg cagctgtagc ctaataaaat gagtttctta agtcataagg 19620 cttgaaagtc agaattactc agtgatccat gggctgcaga atagatgttg tgttagcagg 19680 catgaataca ttaaccttct tgtacatttc catcagagct catgggaatt tttttttcta 19740 agcagtaggt ctcaacagtg ggcttaaagt agttagtgga ccatgctgta aatagatgtg 19800 ctgtcactca ggctttgttg ttccatttct agaacacaag cagagtagat ttagcataat 19860 tcttaagggc cttaggaact tcagaatgat aaatgaggat tggctttaac ttcaaatgcc 19920 cagcttcatt agcccctaac aagagagtca gcctttcctt tgaagctttg aagccaggca 19980 ttgacttctc ctatctagct ctgaaagttc taaatggcat ctttttccaa gagaagactg 20040 ttttatctac attgaaaatc tgttgtttag tgtagctacc ttcatccatg ggcttagcta 20100 gatcttttgg ataacttgct gcagcttcta catcagcact tgctgcttca ccttgtactt 20160 ttgtgttatg ggaatggctt ctttccttta acctcataat ccagcttctg ttttcaaact 20220 tttcttttac agctttcatc cctctctcac ccttgataga attgaagaga attatggcct 20280 tgctctggat taggtttggc tgaagggaat gttgtggctg gcgtgatcct ctatccagac 20340 cattaagcgt ttctccatat cagctataag gctttttttg ttttgttttt ttgctttctt 20400 atcattcatg tgttcactgg agtagcactt tttaacttcc ttcaagaaca tttcctttgc 20460 atttacaact tggctaactg gtgcaagagg cctagctttt ggcctgtctt ggcttttgac 20520 attcctccct cacgaagctt aatctttcta gcttttaatt taaggtgaca catatgcaac 20580 ccttcctttc acttgaacat ttagaggcca ttgtagggtt gttaattggc ctgatttcaa 20640 tattgttgtg acacagggaa taggaaatca tgaagaaaga gacaaggaca gaatgccaat 20700 tggtggagca gtctgaacac acacatttat cagttaagtt tattgtctta catgggcaag 20760 gtttgtggca cccaaaaaca attacagtaa taacatcaaa gatctctgat catagatcac 20820 catagcagag atgataatga aaaagtttga aatattttga gaattactaa aacgtgacag 20880 agacaggagg tgaacatgtg ctgttggaaa aatgatgccc atagtcttgc tggatgcagg 20940 gctgccacaa accctgaatt tgtaaaacat acaatatttg tgaagtacaa ttaagcaaag 21000 cgcaataaga tacgatatgc ttgtatctcc cttaattttc agctaagagc tgtttgagaa 21060 gttactgcca tctccttttt tcagatataa gaattaaaac aaggaaggaa gttaactttc 21120 ctaaagatac ctagccagtt agtaatggag ctggtaacca aacccagttc tggcagactc 21180 caaaaattaa accgctttca ctaaagcaca ccactgggca ctgtgtttga agcacgagat 21240 gatattagca actgattgaa gatttattga aaagacttaa aactcttatt gtagtcaagt 21300 cgtttaaaaa tattttttac ttttaaaatt tattattatt tagagacagg ctggagtgca 21360 gtggcatgat catagctcac tgcagccttg aactcctggg ctgaagtgat actcccacct 21420 caacctccag atattttttt aatagacaag gctttgcttt gttgcaggct ggtctggaac 21480 tcctggcctc aagcaatcct cccaaagtgc tggagtttca ggcataaacc accttgccta 21540 ggctcatttt tttttttttt tttttagacg gagtctcatt ctgtctccca ggagtgtaat 21600 ggcacaatct ctgctcactg caacctctgc ctcccaggtt caagtgactc tcctgcctca 21660 gcctccagag tagctgggat tacaggtgcc caccaccaag cccacctaat ttttttattt 21720 ttagtagaga cagggtttca ctgtgttggc taggctggtc tcaaactcct gaccttaagt 21780 gatctgcctg cctcagcctc ccaaagtgct gggattacag gcgtgagcca ctgcacctgg 21840 ccagttcaaa tcttatatat tttggtgcct agacttaaat aacatttagg aaaatgttaa 21900 ttaattatcc atatagttct acctttttct ttcttttttt ttttttttac aaagccagtt 21960 tcaagtaaga ctggggagat tctagaaagt tataacagaa tcttaagtca cttgatatgc 22020 ctaaacagaa tttgaagaaa taatgaagtt gaacacattg ataaacttag gatttctgta 22080 atcaggaaga aaaaactaaa cttcatagat atgagggaag gaattaacca tttgcatgta 22140 tgtaactgtt ataatcctac atcagagtag cacaaggaca tgaacaactt tgttgacaaa 22200 tagttttgta attttttaat gttttttatg tagctgtctt aaactccttt ctcaatagta 22260 tgtgaggtca aatgattgtg gtttcttttt aaaattttgc atgtaatgtg tagttcctta 22320 cattctctaa atgcttactg tttagctaac tatgttatta tggatgtcaa ttataactaa 22380 gtacttcata caatttcacg ttttataagt tagaagatat gtgaataatt agggcatttg 22440 gaagagttcc agagagattt ttttatttag aaagagagga gcagaacagc ttcaggaaag 22500 atagatgaaa agctgattca ttcaatttaa gatagttgaa gggaagaaaa aagaacacat 22560 tatttagaat gatgacatga agaacttaat ttcctttttt tacttatact ttaagttctg 22620 gggtacatgt gcagaacgtg cagttttgtt acatagatat acacgtgcca tggtggtttg 22680 ctgcacccgt caacccgtca cctacattag gtatttctcc taatgctatc tctcccctag 22740 ccccccatcc cctgacaggc ccaggtatgt aatgttcccc tccctaagtc catgtgttct 22800 cattgctcaa ctcccactta tcagtgagac aatgcggtgt ttggttttct gttcttgtgt 22860 tagcttgctg atgatggttt ccagcttcat ccatgtccct gcgaagaaca tgaactcatt 22920 cttttttatg gctgcatagt attccatggt gtatacgtgc cacatttgct taatccagtc 22980 tgtcattgat ggacatttgg cttggttcca agtctttgct attgtgaata gtgcttcagt 23040 aaacatatgt gtgcctgtgt ctttatagta gaatgattta taatcctctg ggtttatacc 23100 cagtaatggg attgctgggt caaatggtaa ttctagttct agatccttga ggaattgctg 23160 cactgtcttc cacaatggtt gaactaattt acactcccac caacagtgta aaagctttcc 23220 tatttctcca catcctctcc agcatctgtt gtttcctgac tttttaatgg ttgccattcc 23280 aactgccatg agatggtatc ttattgtgat tttgatttgc atttctctaa tgactagtga 23340 tgatgagcat tttttcatgt ctgtcggctg cataaatgtc tttttttgag aagtgtctgc 23400 tcatatcctt tgcccaattt atgaggttgt tttttccttg taaatttaag ttccttctag 23460 attctggata ttagtccttt gtcagatgga tagattgcaa aaattttctt ccattctgta 23520 ggttgcctgt tccctctgat gatagtttct tttgctgtgc agaagttctt tagtttaatt 23580 agatcccatt tgtcaatttt ggcttttgtt gccattgctt ttggtgtttt agacatgaag 23640 tctctgccta cacctatctc ctgaatagtg ttgcctaggt tttcttctag gatttttatg 23700 gtttgcagtc ttacatttaa gtctttaatc catcttgagt taatttttgt ataaggtgtt 23760 aggaaggggt ccagtttcag ttttctgctt atggctagcc agttttccca acaccattta 23820 ttaaacaggg aatcctttcc ccattgcttg tttgagtcaa gtttgtcaaa gatcagatgg 23880 ttgtatatgt gtggtgttat ttctgaggtc tcttttctgt ccattggtct atatatccgt 23940 tttggtacca gtgccatgct gttttggtta ctgcagcctt gtagtatagt ttgaagtcag 24000 gtagtgtgat gcctccagct ttgttctttt tgcttaggat tgtcttggct atgtgggctc 24060 ttttttggtt ccatatgaag tttaaagtag ctttttccaa ttctgtgaag aaagtcagtg 24120 gtagcttgat ggggataaca ttgaatgtat aaattacttt gggcagtatg gccattttca 24180 ctacattgat tcttcctacc catgagcatg gaatgttttt ccatttgttt gtgtcctctc 24240 tgattttctt gagcagtggt ttgtagttct ccttgaaaag gtccctaaaa cttcatttct 24300 aaaaaaaaaa aaaaaaaagg aatatgctac caaataggat tctttaaatc aattgtctcc 24360 tccttcagaa aacatccaga acctgacctc ttatcaccac ctccactgac cactttggtt 24420 taagccactc ttattcccct tcggatgtat tgcagtggtc tcctgacagt ctcatttcta 24480 tccttacctt cctagattcc agaggttgag agtctgccct cgacttagaa gccattgtga 24540 tactgttaaa atataagtca gatcatgtta gccgtctgct ccagtgtctc cagtggtacc 24600 atatctttta gagaaaaatc aaatttctta cagtggcctt caaggcccta cagcatctgc 24660 actctgctgc actctgattg tactatctac tactcttctc cctggcttag ccagctctag 24720 ccttactcac atcctcaaac aatccctgtc atctcttagc atcttagcaa tttcttcttt 24780 cctctctaat tcctttcccc aacactcccc acttctccaa cccattccag cttccagctt 24840 ccagcttcca tgagtatcct gaaacataac aaactttggt tactgccagt gtctcactta 24900 acacattccc ccactacagt gttgtcaagt tgtttcattt aacaccagta acatttaata 24960 tcagtaatag ccagattcta tcttaggaaa aatatgccta aaatttattt gctgaaaaaa 25020 aaagaaaaga aaaatttgga taataatctg ctttgagtta ttacaaacac agcagtatct 25080 gagaagcaag actgagtgtc ataaggaaac aaccagatta aataaaagca tagctggatg 25140 agataagaaa atactgcagt gtgatccaaa atgcagtaac agagttaaaa tccatattgg 25200 tcgtcataaa gagcaggaaa taacaccaat tatgtagagt tcacatttaa ggagttactt 25260 cggaatgaag agaaattggt aaactggtga aaattacaca ctatgattta ttgtttttat 25320 tatgtaccag tcattgtggt aacatttcat ctaatttagc tcacttaatc catataacag 25380 ccttataaaa tgtttatctc tatattatat gtgggaaaaa ctaagatttt gattaaacaa 25440 ttttatcatg ctgcagaaag tgacagaact gaatttgaat gaaagtctat ttgactctaa 25500 agcatatggc cttatcacta tgctgttgga caacagatac gatgaataga gagcacatat 25560 gcaacccata aatatccagt gattctgaag aagaaactaa aaaacaaggc agcaaaagta 25620 ttaattgatt atagaaaatg actcttcctt atgtatcttt tttacgagat catttctaca 25680 ttgtgtcacc agcacctaga acaatgttgg cacatagtag atattcaaga aatatttgtt 25740 tattgaactg tcataattac tgttaagcat ttattctgtg tctgttatgg tgctatagat 25800 tttatataca ttattttacc ctcaaagcaa cttttaaact gttattttat agatgaggat 25860 aatgtagtgc caagaagtta aatgatctgc tcaaggttat atagctaata ataggtggta 25920 gaacacgtat aacagaagta agtttagcag ttaaataaaa attttacttt ttagatcaaa 25980 aggactcact gcatcccagg taaatgtaat tttaaaaagc taaaactttg caatattggt 26040 aattttttaa aatttttcat gagaaggaaa aacaccctat atgcatttaa gtaggattaa 26100 taaaactggt taactactaa gacataaaaa ttgggttgac attagatttc ctctttgagt 26160 actaaatgct gagattggca aaaattccat caggttgagt tgctattctt gggtgaagat 26220 aacatatatt cttatatatg tgagaggtca ggaatatgcc cagtctttac cgaagtactt 26280 gtttgtctga tggttggact aatttgggat tcctgtagtg tcctgtagtt cagggtgaag 26340 tttagtaaca tgcgggggta agagacagga ggtgctattc tctgccctgc tgctcaccag 26400 tgtgctgtat ccctcctcag gatcaccctt aaggtctcag atgctcacac ctggtgttca 26460 gtgcccagtg gtctgttctc tagccagtat attctgtgtc gtcttagatt ccagtccaaa 26520 gactatttag atctgctcca tccttgggaa tttccacgca ctttattatt tcttctaggg 26580 caggggtccc caacctagaa caagcctacg atttgtgggt cataccatac tgactttcac 26640 catttcactc cttgaactat tgaacataca ttatcatttc tcctgccatt ttactcacct 26700 gctgctcacc tcctgctgtg aatcaggcca cacagcagga ggtgagcagc aggtgagtga 26760 gcattactgc ctgagctgca cctcccatca gaccagtggt ggcattagat tctcatagca 26820 gcgcaaaccc tattgcaaac tgcgcgtgcc agggatctag gttgtgctcc ttatgagaat 26880 ctaactaatg cctgataatc tgaagtggaa caatttcatc ctgaaatcac cgcttccccc 26940 aacccccccc acccctcact gcccccagtc cgtggaaaat tcgtctttca tgaaacctgt 27000 ccctggtgca aaaaagatta gggactgctg ttctagagaa attaaatgtt tttatgtcta 27060 ctttgttaca aggttacatg aaataaacca gttaaatgct tagtatattg gtctctaata 27120 tactcaataa gattttcctt ctctccttca ccccacacct ttttccttca cttttatcaa 27180 aaatccttgg atcttcatga agatatttta aaacctactg atttgttatt gtccagctgt 27240 ctttcacact ctgctagata gtcactcttc attccacttt acatgaccat cccctgactt 27300 actaacgtga aaaactggtc tgaacctttg tctcattctg catgcatctt cagaatatgc 27360 tggattccag aaaacataca aaaaacttta aggaatagta cagcgaatat ctgtaatcaa 27420 caatttgaag gtaagttgca gacatcatga catttcacct cttaaggctc caaaattcat 27480 gtcctaagga caagaacatc ttccattaca accacaatat tatcacccca aaattttaac 27540 attgataaaa caattctaat attcagctag tattaaaatt tcttcagttt ttcccaaaat 27600 gttttgtata gaatgttttt ttattcagga tccagtcagg aattgtgtat tttacttggt 27660 tagcaactct gtttagtttt ctttaatcta aaaagatctc ccaccttttt ttgtctttca 27720 ggacattggc atttttttgg gagtctaggc cagccgtttt gtagaaagtt ccataatctg 27780 gctttgtctg atttttcccc cacataatta tatgccagtt aaacgttttg acaagaatcc 27840 tacacaggcc aacggttctc agacactgat ctcatgaccc ccttatgtgc ttaaaaattg 27900 ctacaagccc aaagagcttc tgtatacgtg aattctctct ctcagtattt actgtgttag 27960 aaattaaaac tcataatgtt ttaaaacttt ttattagctc atttaaaaaa cagcaaaccc 28020 attagatact aatttttcaa accaaaaaat ttaatgacaa gaatgacatt gttttacatt 28080 tttataagtc attttaatgt ctatcttaat agaagacagc tggattctca tatctggatc 28140 tacagtcaat ctgttccaat atgttgtttt ggtggaagca tgggaaggaa atgtggcctc 28200 acacagatat gtagttggaa aatggaggag tattttaatt gtcttttcag acttgacaag 28260 tggtggccat ttcattagga attgcaaaag gatgattctc tatttctatt atcccttctg 28320 attttatcag ctataaatat ttttaatagt tctctctctc ttccaagagg caatctggta 28380 atcttaaaat acacttaata atggaaagcc taacagatac ttattattta cttttaattt 28440 tcagttttca aagttgttaa gtttgtgccc tagtaatctc cagtggtttc cagtgagttc 28500 ctcttgtttc tttcattctt tctcttctta catatcatta tgtactcatg ttttttaaaa 28560 tatatattca atgtgtttta attacttgaa ccagttcttt ttgatgttca agtggtttta 28620 attttggttg gtgtgaatta tcagtggtca atgaaacaca attttattag ccctcagtaa 28680 aagcaaatca tctgtcacag caaagcatcc caggctcaac ttgcacattt cctgccctag 28740 tcctggatca gtcatttccc caaggagctc tggttcgttt tagatgaaaa ttatattaca 28800 tgtgaaaatc tgaattcctg ctggagttgt ctttactttt gggcattttc agtgaagaga 28860 cctagaaaat acctcttttt gaaaaagtaa ggggatcatg agtttatacc atgatttctc 28920 aacctcacac tattgaccta ttgggccaca taattgttgc agggggggat gtcctgtgca 28980 ttatgggatg ttattagcct ttttggcctc tctgcaataa tacctaccct ctagttgcat 29040 aaaccaaaat tgtctccaga tattgtgaaa tgtcctggtg aggaagggag caaaattgcc 29100 tctagttgag aattactggt ttatgtttgt atttctagca aaatcaaaat aattactagt 29160 tgttttatct gtatgtattg tgtgtgtgtg tgtgtgtgtg tgtgtgtgga ttcaaaatac 29220 tagtatcagc attattacct ctaacaacaa aacctgcttt gtagactagt tcttccatct 29280 cctgcataaa atcttaggcc agtcccaaag attttaatca gaagaacaat ctcattccac 29340 taaccgtatt agtctgttct catgctgctg tgaagaaata cctaagactg ggtaatttat 29400 aaaagaaaga ggtttaattg actcacagtt ccacatggct gggaaggcct caggaaactt 29460 acaatcatgg cccaagggga agtaaacatg tccttcttta caaggcagca ggagagagaa 29520 tgagtgccag taggggaaat gctagactct tataaaacca tcagatctca tgagaattca 29580 ctgattgatc acactgctca tgatgatcac gagaagagca tggggggaaa ccacccccat 29640 gattcaatta cctcccactg agttcctccc acaacatggg gggattatgg gattacaatt 29700 caagatgagg tttgggtggt gacacaaagc caaaccatat cagtaatcaa aatgcccagg 29760 gaagcattat gccaaattta caaatcctct tctaagttta gatttcttct ttgccccaat 29820 tcagcactca ctgctttgag cttgaagcct aaagggaaga acaaataaga tctgcttctt 29880 ctctgtttat gctgcctaca ctcacccaat gacagctgat tttgaccctt ccagggccaa 29940 cgtgtgggaa gagaagttag agagcacagt tttacacaac aagtaggaat tttagtgtca 30000 ctggggttat ctgtgtttgg tgggtgatta caggctgctc ttcctctagt gggatacttt 30060 ggtgagattc atggagatac tttactgaga gcctctaact gtaatcctgt aatgctgtaa 30120 tgcagtagac acctctcttc tctctggaca tgaccgtgac cctctgcttc tggacttccg 30180 ctgactgacc ctacacagat tctgttggat cacaatactc tctaggttgt cctcttagct 30240 ggagccagtt tttaaaagaa agaaactttt attgataaat attttcagaa aagcactcaa 30300 agatgtagag cttatcagta ggtaaatgaa acgatgttat tatcacccag accaaaaaat 30360 ttaaagatca ttaggttccc agaagctcca ttttgcccct tccaatcatt ccccaaaagt 30420 aaccgccatc ccaatttcta acatgataga ttggtttgaa ctattttaga actttatatt 30480 aatggaatca gatagtattt ttctatgtct gcttatttta cacaacatta tacttatgta 30540 gttcatccac attttgcatg gagctagaca tttattctca ttgctgtata ataatgcatt 30600 gaataaataa aaccatttgt ttacacatta tgctgtaggt gatcatttgg gttgttttca 30660 gattgaggct attatgaaca ctgctgctat aaatattctt gtacaaatct tttatttttt 30720 gcatgtggac acacctgtcc ctacagataa gcttttcatt tgcctctcca aggaccctgg 30780 caatttcact ggtcctgtac cagtctttgt tccttggccc aggttcctat accatgtgat 30840 agtgaaaatt cacctcccat taaaggccaa tattttattt tgtttatgtt gtttttggca 30900 taaatgattt ttgtcctcac cctgaatttt ggacagattc ctggctgcct ggcattttct 30960 gtgtagtgtt ttctagccct gttttcattg ctaaggcagt cttttaaggt tctacatttt 31020 tatgcatata gttcagccct gccactctct tccattggga ctgaagtaat atatcccatc 31080 ctctcatggg ctttaaaccc catttcttat cttttaggca tttcttatat ctgtatctga 31140 aacttttttg gatcactgca gagtccagtt aagtttgttc ctccagcttt catttctttt 31200 ttcttttctg gcttatagag atttacctac ctttttttcc agactgaaat taagcaacat 31260 gcttctatta tattttatcc agtatttctg tgtttgtggt agaaagattg ccctcatatg 31320 gaccagctca tgttgcttca agcccgtgac ttgtgggtca taccatactg actttcacta 31380 tttcattcct taaactactg aacatatatt atttcctgcc atttgactat gtattttccc 31440 cttcttttca aaaatgccat gaaaaattgt gaactctctc agacctaagt gaactatgtt 31500 cacttgtgct catattgaga agcaacacaa acaatatagg tctcttattt tacaggtaag 31560 tccctttctt gtttctaata aagatatttt atttcctaat aaagatattt tatttccttt 31620 aaagtggaat tttgtcatct aaaatttttg taagtcacta ggcaaataaa atgatctaat 31680 cacattttga tagtgctttt attttcacag agtatttttt attaagagta acacttgggg 31740 ctgggcacgg tggctcacgc ctgtaatctc agcacttcag gaggccgagg caggaggatc 31800 acaaggtcag gagatcgaga ccatcctggc taacacggtg aaaccccatc tctactaaaa 31860 atacaaaaaa ttagccagac gtggtggtgg gcgcctgtag ttccagctac tcgggaggct 31920 gaggcagggg aatggcatga atccaagagg cagagcttgc agtgagctga gatggctcca 31980 ccgcactcca gcctgagcga cggagcgaga ctccgctcaa aaaaaaaaaa aaaaagagta 32040 acacttggaa ataatcttgt tagacttcac atttaattat ggtctattac tataaaaagg 32100 tgagaaatta ctgaataaaa agcattctgt aagaaaaaaa gttaaaaggt ggtaaaaaat 32160 cagaagcaag tgactattta ctatatatga caataagtga catatgtctt atactgttga 32220 gtataactat atttacaaat ataagcgaaa caataggtat aattgtatat acacctatct 32280 aaaaaatatt tatcaagctg tattttacac aagagttaaa agtatcaaac tgagtagttc 32340 ctactcttat agaacctagt agctatagac acaaagtata caataggaat acattgaatg 32400 tgcagttggt acacagaaga aatgtctaaa gcctttatga gagcagtcag gtaagaccag 32460 atgaggggag cagttaagcc aaggcttgaa agacgagtga gattttgtta agttgataaa 32520 ttggaaggaa gggaggaaag tcatagaggc atgagagagt ttgggggtaa tccaaggatg 32580 ttagtactct ggagcataaa gaacatggga aagagtatgt gattagaaag aaaagacata 32640 acagtttgaa ctcaccccct gctttcccca ccctaaaata gatcagtttt gcaaggagaa 32700 agaagcatag tgctctatta agctccccag gtttcaacag gggcagatga tgcatatatt 32760 aagggagaga gctagatagt ggctcctagt ggggtgaact cccctattta tcattatgcc 32820 atgtaacctg tttgtggtgg cttatagctt ataagtgttc ctaaatgtct tataactcct 32880 ggtggtgata atgtaggtaa acagcaaaga tggcagcaaa tggaatgctc tgagtggttt 32940 aatatagtga cgtgttttac acttgttgta gaatcacaat gttatgttgg actgaggaga 33000 agaaataata cgcaatttga gccatcaacc tacggtttat gagtgagtga gtggatctag 33060 acagggatgt gtttctcaaa accagaatat aaactgtggg ctgttgtctg aagaaaatgg 33120 tagcaactga tgttatgtta gattttcatc tttttctaga tttccaggaa aatgttgtga 33180 cagggctaat gcacttgtgc ctgacctttc ttcacctgca tatacagcca ggtacctgaa 33240 gtagcgagtg gctcccactg cattcattgc attcttggtg gctctgagtc ctggccatgc 33300 attatggttc agaggcaatg cctgggcccc atgccaaatt cccttagtcg gctctagttg 33360 gaactggctg gctacaacat ttctttaagc caaaacattg cttgagaaga taaaccttta 33420 actgtactcc ccatattttg tttgcatgat aatgcatcta ctttgcagtt ttgatggctc 33480 atcacttaat gttaaagatg atgaaaagtt agagtgaatt gagcttccag atttctttaa 33540 gccattccag cctgtcacag gcagtctaca atgatatgag tcgtgccaac ccctcaaggt 33600 cgtgacttca tgccagtgcc cttaattatt aaaaattatc cttccaactc aaactttaaa 33660 tattggacat ctaagtcatt ttttcttcca aacttataag aattgcattc tgtttggtaa 33720 ctataatttc cttatttata ctcatgttta aatttatact tatgtttaaa tttatttggt 33780 acttatcatc agtctcttca taccagactt cctacctcat acattgtctg ctataacgta 33840 tctgttgttg actggattac atcttttgga agagcatact ggggtcttat ttcccaattt 33900 catgcaagtt tgagaatatc tttaagttgc ctttaaaact gaataacttg actagatata 33960 gacttcttgg accacatcta gaaaaaatct aactatattt gagatttaga tgtgtgataa 34020 tcataattat aatagacatt tgttaagtac ttgctatgtg ccagactatt ctaagctctt 34080 acatgagctt gtgtattcct tagatccaat ccaaggtact aatgttatct tcattttaat 34140 tgccaaatgt catctagcta ctaagtgatg agattgacat tcacacttaa acagtaactt 34200 tctatactac ctctcaagat aattaaccta aaatgtttta actgtgtgac cttgagcatg 34260 ttatttaact tctagatgcc tcagttaact ctgtataaaa tgagaatatt aatacctcca 34320 aaggttgctt tgatgatgaa atgagttaat atatgtcaat agctcataac aatgcctggc 34380 acatagtaag tgcttaataa ttgtctgttg ttcttttatt atttttattt gtggatagta 34440 agttgcagat ctgagctttg aacaagcagt ctggcctctg taactttgct cttcggtact 34500 acaatgtagt gtcagcaatt aagatggcat tttaatttag tgggggaaaa catggattag 34560 tcagtaaata gtgttgggat atagtagata ctcaatactt gttgaatgaa tgagagtttt 34620 ataaaagtat aaatacatta acttaaatat taacaaatag atattaaata ccatttagat 34680 ttgtatagac agtttggaaa tactttagtc tgttccactg caataaaaaa ataccttaga 34740 ctgggtagtt tataaataca gaaatatttt ctgatggttc taaaggctga gaagtccaag 34800 atcaaggtgg cacagattcc atgtctggta aaagcttgct gtcttcttcc aagatggcgc 34860 cccttgctgc atcctcacat ggcagaaagg ataaaaagga ccaaattcac tccctcaagc 34920 ccttttaaaa gggtactgat tccatccatg gaggcagaga ccccacctct taatattgtc 34980 acattgggga ttaagtttca atatgaattt tgaaggggac acaaacattc aaaccatagc 35040 aagaaggaag caaaaatgag aatagatgca tgattatcaa attgtaggtt attttctgtt 35100 ttgaatttcc ttacgttctt atataatttc tctaataata caattcatga tataatttgt 35160 acagataacc acttagttgt attttgtata tattgagttt gaggtaccta gaaatatgac 35220 tggaaggtca gagctcatat tgagattttg ggaccatcag aagataatga gacagactac 35280 ccacaaagtg tgtgcagtgg cacaccacat ataaggaata agcaaagtaa gaggagttga 35340 caaagggaat ttaaaaggaa gtgctggaaa gacaggtcaa gagtcagaaa agagaggccc 35400 caaaatatga atcaatggga caggtgggga aagaaattac ctgaagcaaa tgattcaggt 35460 caggaaagca ttcacagcat ttaggaatga aaaaatattt gatgatgtta agccatttta 35520 taagaatagt gaatatacaa gtcaaattac cacataggaa taaaggaagt taggtagaaa 35580 cagcaaatgt agatgatgtt ttcgacaact ttgaggacca aaaaaagggg aatgtattca 35640 gggagaatct agagtgagct agggttcctt tttttggtgc tggaactttt ttggatggaa 35700 aaataatgag agagcaggac atcactggac tggagagact aaagacttta ggagagaaag 35760 gaggaaattg atggagcaag acttgaaagc agataggaag gaattgtttg aaggacaaaa 35820 gcaaaaacca ttggtaagga ggactctttg agacactgaa taaggagatg atatcgtagg 35880 ccattttaga aatgtaagtg agacagatca gcagcatgcc agcttctggt gtttagatca 35940 gacctttttc ctgcgtattt atgaccaagg agcagacagt aggacagcct ctcttcaaac 36000 aattacatct gcgtgctcta tttctcgaag tctgttttct gtatagagaa aaccttggtg 36060 ggcgtggtgg ctcatgcctg taatcccagc actttgggag gccaaggcgg gcagatcacc 36120 tgaggttggg agttcgagac cagcctgacc aacatgcaga aaccctgtct ctactaaaaa 36180 tacaaaatta cccaggcgtg gtggtgcatg cctgtaattc cagctactca gaggctgagg 36240 caggaaagtt ccttgaaccc aggaggtgga cgttgtggtg agccgagact gtgcctttgc 36300 tttccaggct gggcaacaag agcgaaactc cgtctgaaag aaaaagaata gaaaatcttg 36360 ctattttctg ttctctcttc ttgtgagata tcagtatagg gtagaaatag atgatcaact 36420 gatagactga cttacacaca ccttgctctc acagtcactc ctatagccta aatatataac 36480 ttgtggtaaa aaaaaaaaaa attagagtca aatcagaaag tagtatgcag tacactctgc 36540 taacctcctg taggactggc actatgtgca caaaagtcag caaagatatg aggcttcaca 36600 gttacccttt attaggtgaa ggcttaattc ctgggactct aaacaagaga tgaacactat 36660 gtgagtgtac atgaacataa gtttatagag gcatgcatct ttaagaaaat atttgtgctt 36720 ttccagaaat gcatgaggtc aggaaccttc ttgatatcag ctgtcacata tataggcctt 36780 ttggcatttt tgccctttgc cgtttaggct aatcctttcc cctgcttgat taagtacatg 36840 ttttaggtac ctctgagttc ctttactacc aactttggcc agaagactct gattttaatc 36900 ttaactaatg taaaatacta caggaaaatc ccatgatctt ttaaaattat gtgtcatgct 36960 tcagcagtat aagtaggctg aagtaggctg atgatattaa aagactcaca gtctgtttta 37020 aagaaattta ttgggaaaaa aagagagtgt caaaaatagt aaattaacgt ttacatgttt 37080 aagctgaatt tttttatttt tgttaaatct aaataaatta gattgttccg tgccttatta 37140 acatatttgt ggtttaaaaa tcattattga atattaaatt catgtgccag acctttttaa 37200 aggcatccat agtttcctct acacaaagtg accccagggt gatgtgcgat gtgtattgtc 37260 tatacttcta taaagtttct cctctttatt gagtacttct atctgtttta agttcttcct 37320 ttatcattat ttctgttcaa ggtattttct aatgtgtagt caaaataagg caggtattaa 37380 attcagtaca ataagtgatc ttttttacat gctcttccat tgattcctta aagagagaac 37440 cagctctggg atttttccaa tagaactaag catttagatt tttttttaaa aggtcttttc 37500 cagaggcctc ttcaattctt tagtctgtat ctgttttctt gaaggcatca atgtcagaaa 37560 gaaaggtttt actagagttt gaccacctgg tacaactaat gcttatcaga aacgtgtagc 37620 taatcttgaa atgacatcta aaggcaatct gatactgaca ccattaagaa gataaacaga 37680 aatctcttgc aaaagatttt taaaggagcc ctaggattga ttcttcagct atgctcacct 37740 aatttaggct cctaaaggca caggtaaagt actgagcagt tttatagctt caccaacatt 37800 cagctgtgcc aggcaggaag ctggctgagt catgcacttg ctgatgtgta tctagtctct 37860 atttcagttg tcactgcata gaatttccag tgaatcttag atattgtaaa taattttgac 37920 tcattttgtt tttttagggc agcacaacta cttatgtgct ggaagaaatg actgcatcgt 37980 tgataaaatc cgcagaaaaa actgcccagc atgtcgcctt agaaagtgct gtcaggctgg 38040 catggtcctt ggaggtaatt ctgatgtttt catcaataat atactgtgta atctttatac 38100 tataaaactg tgtgtcagaa aattgcaatt tcttattcat ctttgttttt gttttttctg 38160 tcttgattat tggcagtgac tctgcacatg tgagtgtctg aatgaagcaa ccaataccat 38220 tccattaact ttacagtttt ctagcacatt gaggtctgtt aagagaagaa aactcaattc 38280 atctatattg cctataagta gaggtaatgg gcaatgtact gacctgtcat taagtaacat 38340 gtgtgggagt ctaggctttg ctgcccatct cctgtgtgac cacagctctt cctgggcatc 38400 agtctactta tctgtaaaac gagagcatta acattccttt cagctcaaaa aattgactct 38460 gcaaattggt caggtacatt gcttactagc ttctccaagt gattgattaa agcaagatta 38520 ctgtaactgg ggtaggaatc catttgatga agagttatat taataattcc cttttcccat 38580 atttttatta gaatctctaa aactttcagt aatatagcac acatttaaaa aattaatgtc 38640 agatagtgac agatagtttg aatgaaaaca tagcagagtg agggagatca agcgagccac 38700 agttatgcaa gacacccgta ctcccttgaa ttttttcact tagccacatc ctgcacaaca 38760 ctgtctggga atcgtagctt ttacatctag atataacttt ttaaaaacat aataaaaata 38820 ttacataatt gttaaagcta aaaatgtttt ttcagtgcac taactataaa cagcttgtgt 38880 tccatggacg ttgtgtgtat tttcctttgg gaaatgctat atttagacca atgcttgtca 38940 agtttaaagc gtatacaact gtcacctcat ttgtttttgc aaatgtgctg gaccaaaatt 39000 aatcacccag gtaacatact gggcacttta cagtaattca tgtaattaga tcacttatag 39060 aattttataa tttcttgatt aaagatttgt tttcctaagt taagggcagt gattaggttg 39120 acagtagtgc ctggcttaag gaggtgctca gtaactttct attaaatgaa taaaaccaca 39180 acctcagcag attaaaattg tttttgagtc ccacacctca attaccacct ctttgtattt 39240 ctgtttcaac tcagaagtct taaggaacct cctaaatttt agaaaataca actttttcac 39300 aaaatcacac atctagtcaa tgtcggagcc agaagaaaga cctgaaggta ttctgaccct 39360 ggcgcagcca ttgttttctc cttggcatgc ttgccttaga aagtagcaga gcatctaatg 39420 ctgacactta gattccatta agatctttaa tcttgagtgt tttcccaatg actttaaaag 39480 actcttcaat tttatcaaag aatgaaaatg gcggagttct ggatagaacc ttcagaatac 39540 tcctggggat cagcaatata acctagagaa atttatgtta tcttttaata ttctagggct 39600 ttatttattt atttttgaga cagagtctca ctctgtcgcc caggctggag tgcaatggtg 39660 caatcttggc tcactgcaac ctctgcctcc caggttccag cgattctcct gccacaacct 39720 cccaagtagc tggtatcata ggcacccgcc attacgccca gctaattttt gtattttagt 39780 agagatgggg tttcaccatg ttggccaggc tggttttgaa ctcctgacct caggtgatct 39840 gcccacctcg gccttctaaa gtgctgggat tacaggcgtg agccactgca cccggccttt 39900 agcatattat tcaagcatct gtaatccttt atcttctcta accaaactgc ttgttacttt 39960 agcctgttat tcctatgctt cccaagccat attctacggg cttcacagct attgctgcat 40020 tttcatacct tttatattac ttatttgttt aactctactc cctccatctc tccctccttt 40080 ccgtccctcc ctccctccct tccttcttct ttccttcctc cctcttctcc ctcaatcgct 40140 ttctaatttg caccccatcc ctttctttca gtaactgtat atcgagccct ttctagttac 40200 cagatactat tctaagttct gcgcatatag cagcaaagaa aatggacaaa attcctgccc 40260 tcatagatct tacactgtgg gaggacgagc aacaaatgta catgtcaaat aatgataagt 40320 gctgtggaaa gatattaagc agagttagtg gggattatca ggaagcagac tcactactaa 40380 actcattagt ctaatatttt tgttttgctt agcctcttcc taagcaataa tatctctgaa 40440 ataatggatt tgatatgcca gttataattt ttctaaaaga cattaatata cattcttaac 40500 tatttaaata tatattcgat gtaccaccta aaaactgctt gtataccata aatgattatg 40560 tgttaaactc tgggaaagag tgtattagac catttttttc cagctatcgc agctctattt 40620 attttttcag cttttatttt agcttcagtg ggtacatgtg caggtttgtt acctgggtat 40680 attgtgtgac actaatgttt gaggtacaaa tgatcccatc acctaggtac tgaggtactg 40740 agcatagtac tcaatagttt ttcaaccctt tcttcttctt ccttcctcct ctagtagtcc 40800 tcagtttcca ttgttatgct catgaatacc caatgtctag ctcccactta taagtgagaa 40860 catgcagtat ttggtttttt gttcctgtgt taatttgctt agggtcttgg cctacagcta 40920 catccatgct gctgcaaagg atgtgacttc gttcttttca tggctgcata atattccatg 40980 gtgtatatat gccacatttt ctttgtccaa tccactatta atgggtgcct cagttaattc 41040 catgtctttg cttttgtgag tagtgctgtg atgaacatgt gagtgcatgt gtctttctag 41100 tagaacaatt tattttcttt tggctatata tccagtaatg ggattgctgg tctaatggta 41160 gttctgtttt aagttctttg agggccggga gcggtggctc atgcctgtaa tcccagcact 41220 ttgggaggcc aacgcaggtg gatcatgagt tcaggagatg gagaccatcc tggctaacac 41280 agtgaaaccc cgtctctact aaaaacacaa aaaaattagc caggcatggt ggcaggcgcc 41340 tgtagtccca cctacttggg aggctgaggc aggagaatgg catgaacctg ggaggcggag 41400 cttgcagtga gctgagttcg cgccactgca ctccagcctg ggcgacagag cgagactgtc 41460 tcaaaagaaa aaaaaatgtc ttttgagaag tgttcaaacc aatttctacc gtggcagaac 41520 taatttacat tcccaccaac agtatataag tattcccttt tttccacagc ctcaccagca 41580 tctattaggt tttgagtttt ttgagttttc ttttttgaga cagagtctca ctctgtcacc 41640 cagactggag tgctgtggca caattatggc tcactgcagc ctcaatctcc tgggctcaag 41700 tgatcttcct acctcagcat cctgagtagc tgagactaca ggcacgcacc accacacctg 41760 gcaaactttt tatttatttt ttttttgtaa cgataaggtc tcactttgtt acccagtcag 41820 gtctcaaact tctgggctca agtgatcctc ccaaagtgct ggaattacag gtgtgagcca 41880 ccatgcctgg catgagtttt taataatagt cattctgatt ggtgtaagat ggtatgtcat 41940 tgtcgctttg atttgcatat cttaatgatt agtgatatgg agcattttaa atgtttgttg 42000 gctgcttgta tgtctccttt tgagaaatgt ctgttcaagt cttttgccca tttttttggt 42060 gagatttttt ttttttgctt gttcaactgt ttaagttcct tatagattct ggatattaga 42120 catttgttgg aggcatagtt tgtgaacatg ttctcctatt ctgttggttg tctgttaact 42180 ccattggtag tttattttgc tgtgcagaaa ctctttagtt gaattaggtc tcacttgtta 42240 atttttgttt ttgtttcaat tgcttttgag aacttagtta gaaattattt cccaaggctg 42300 atatccagaa tcatatttcc tagattttct tttaggattc ctatggtttg aggtgttata 42360 tttaaatctt taatctacct tgaggtaatt tttgtatatg gtgaaatgta ggggtccaat 42420 ttcattattc tgcatgtgac taggtaggta tcccagcacc atttattgaa taaggaatcc 42480 tttctgcatt gcttattttt gtcaacattg tcaaagatca gatggctgta ggtgtgcacc 42540 tttatttctg ggttctatat tctgttccat tggtctatgt gtctgctctc gtgccagtat 42600 catgctgttt tggttactgt agccttacag tatagtttgg aattgggtaa tgtgatgcct 42660 ctgacttttc tttttgttta ggactgctgt agttatttgg gctcttttga ttttatataa 42720 attttagaat agctttttct agttctggaa aaaatgtcgt tggtagtttg ataggaataa 42780 cattgaatct gtaaattgct ttggacagta tggccatttt aacaatactg attcttctaa 42840 tccatgaaca tggaatgttt ttacatgtgt tagtgtcatc tgtgatttct tttagcaatg 42900 ttatgtagtt atccatgtag aaatctttca tctgcttagt tatatgtata cctaggtatt 42960 ttgtgtgtgt gtgtggctat tttaaatggg attactttct tgatttggct ctcaccttga 43020 atgctatagt tgtatagaaa tggtactaat ttttacatgt tcattttgtg tcctgaaact 43080 ttactgaagt catttatcag ttttaggagc cttttggtgg agtctttagg gttttctagt 43140 tataaaatca tgtaatatgc aagagagata gtttgacttc tttttttcat gtttgaatgc 43200 cttttatttc cttctcttgc ctgactgctc tggctagcac ttccagtgtt aacaggagtg 43260 gtgagagtga gcatccttaa ctttttccag atctcaagga aaattcttcc agcttttgcc 43320 cattcagtct gatattggtt gtgagtttgt cattttggtc tcttattgtt tttaggtata 43380 tttctttgtt gcctagtttc ttgagggttt ttatcatgaa gtggtattgc attttatcga 43440 aagctgtttc tgtgtctatt gagatgatca tatggtttta tttttaattc ttctcatgtg 43500 gtaaatcata tttattgatt tgcatatatt gagctaacct tccataccag gagtgaagcc 43560 aacttgatcg tggtaaatta actttgatgt ttgatttggt ttgctagtgt tttgttgaga 43620 atttttgtgt ctgtgtttat cagagatatt gtcctatagt tttcctttct catggtatct 43680 cttacaggtt ttggtatcag ggtgatactg gcttcagaaa acgagttagg gaggagtctt 43740 tccttctcga ttttttgaaa tagtttcagt agaattggta ccagctctac tttgtgcatc 43800 tggtagaatt tagctgtgaa tctctctggc cagggctttc tttttggttg gtaagttttt 43860 tattactaat tccatttgga acccaatatt ggtctgttca gtgctttagt tttttcctga 43920 tttaaacttg ggacattgtg tgttttcagg aatttattca tttcctctag atattgtagt 43980 ttgtgtgtgt agaggtgttc acaatagtta tctaaggatc tttcatattt ctgtgggatc 44040 agttgtgatg tcacctttgt catttctgtt tgtgtttatt tggatcttct ctcttttttt 44100 ctttgttaat gtagctagca gtctatcaat cttatttatc ctttaaaaaa ataacttttg 44160 gttttgttga ttctttgtat agatttttgg gtctcaattt catttggttc tgctctttag 44220 ttcgtccttt tcttctgcta gctttaggga tagtttgttc ttgttttttt tttttttttt 44280 ttttttttag ttcctctagg tgtgatgtta ggtcattaat ttgagatctt tctaactttt 44340 tgaggtaggc atttagagct gtaaactctc ctcttaatat tgtttttgct acattccaga 44400 gattttggta tgttgtgtct gttttcattt attttaattt ttttttattt ctgccttgat 44460 tttattgttt actcaaagtt atccagagca aactttttaa tttccatgta attgtgtggt 44520 ttgtacagat cttcttgatg ttggtttctc tttgtattcc actgtgacct gacagtatga 44580 ctggcatgat tttgactttt taaaatgtac tgagtcttgg tttatggcca aggatgtggt 44640 gaatcttgga gtatatgttc tgtgtacaga tgagaagaat ttacgttctg tggttgatgg 44700 gtggattatt ctgtagatgt ttattagatc caattggaca agcattgagt ttaagtccag 44760 aatttctttg ttagtcttct gccttgatga tctaatgcta tcagtccccc actattgttg 44820 tgtggctttc taggtcctta gaagtccttg ttttatgaat ctgggtgtgc cagtgttgag 44880 ggcgtatgta tttaggatag ttaaatcttc ttattgaact ctttatcgtt atgcccttat 44940 ttttcctttt ttactgttgt taaagtctgt tttatctaat ctaagaatag caacccctgc 45000 tcttttttgt tttctgtttg catgctacat ctttctccaa ccctttactt tgagcctatg 45060 gttgtcatta catgtgagat gggtttcttg aatacagaag atggatgagt ctggttttcc 45120 tagctggttt gccactctgt gacttttttt tttttttaga tggagtctta ctctgatgcc 45180 caggctggag tgcagtggcg caatctcagc tcactgcaac ctccacctcc caggttcaag 45240 caattctcct gtctcagcct ccggagtagc tgggattata tgcacctgcc accacggctg 45300 gctaattttt gtatttttag tagagatggg gttttacctt gttggtcagg ctggtcttga 45360 actcctggtc tcaggtgatc cacccgcctc agcctcccaa agttctggga ttacaggtgt 45420 gagccactgt gcctggaccc actctgtgac ttttaaatgg gacattgtat tagtccattc 45480 ttgtgctgct ataaagtact acctgagact gggtaattta tgaagaaatg acatttaaat 45540 gactcatagt tctacaagct taacaggaag catagctagg caacgtcagg aaacttacaa 45600 tcaaggcaga aggtgaaggg gaagcaagaa tatcttacca tggcagagta ggagaggtgg 45660 gtcaggggag tgccacacac ttttaaatca ttatatcttg ggagaaccca ctcactatca 45720 tgacaacagc atgggggaaa tttgcctcca tgatccaata acctcctacc aggttcctcc 45780 ctcaacattg ggaattacaa ttcaacgtga gatttggatg gggatacaga gccaaaccat 45840 atcattctgc ccctggcccc tcccaaagct tatgtccttc tcagttttca aaacacaatc 45900 atgccttccc aacagtcccc caaagtctta actcattcca gcattaaccc aaaagtccaa 45960 gaccaaagtc tcgtctgaga caaggcaagt cccttccacc tatgatcttg taatatcaaa 46020 aacaagttag ttacttccaa gatacaatag gggtatgggc attgggtaaa tactcccatt 46080 ttaaatggga gtaactggcc aaaacaaagg agatacaggc cccaagcaag ttcaaaaccc 46140 agcagggcag tcattaaata ttaaagctcc aaaataatct cttttgtctc catgcctcac 46200 atccagagca tactgatgca agggatgggc tcccaaggcc ttcagcagct ccaccctgtg 46260 gctctacagg atacagcccc cacagctgct tttacaggct ggcattgaat gcctgcaggt 46320 attccaggca cacaatgcaa gctgttgatg gatctacgat tctgaggtct ggttgatggt 46380 ggtcctcttc tcacagctcc actaggcagt gccccagtgg gaactctgtg caggggctcc 46440 aaccccacat ttccctttca cactgtccta gtagaggttc tccatgaggt ctctgcgctt 46500 gaagcagact tctgcctgga catccaggca tttccataca tcctctgaaa tctaggtgga 46560 ggtttccaaa cctcaactct tgccttcttc atacccgcag gcccaatacc atgtggaagc 46620 caccagggct ttgggtttgc atcctctgaa gccctggccc aagctgtacc ttggcccctt 46680 ttagcaacag ctggagctgg agcagctgga atgcagggca ccatgtccca aggctgcaca 46740 gagtagctag gccctgggcc tggccctcaa aaccattaat ccctcttagg cttctgtgcc 46800 tgtgatggga ggggctgctg tgaaggtctc tgaaatgccc tggagacatt ttccccattg 46860 tcttgactgt taacatttga ctcctcttta ctaatgcaaa tttctgcagc aggcttgaat 46920 tgctccccag gaaatgtttt tttgtctctc tcttttctac cacatggcca ggctacaaat 46980 attccaatat attttttgct ttgcttcact tttaaatgta agttccaggt tcagataatc 47040 tcttttttca tgcatatgag catacatgtt tagaaacagc caggtcacat acatctggaa 47100 tgctttgttg cttagaaatt ttttccacca gataccccaa atcatctctc tcaagttcaa 47160 agcttcacag atctctagga caggggcaaa atgccaccag tctttttgct aaagcatagc 47220 aagagtgacc tttactccag ttcccaataa gttcctcact ccatctgaga ccacctaagc 47280 ctagactcat tgtccatgtc actatcagca ttttggtcac aaccattcaa caagtctcca 47340 ggaagttcca aacattccca tatctttctg tcttctgagc cctgcaaact gttccaacct 47400 ctgcccatta ctcagttcca aagtcactcc cacattttca ggtatcttct taactgtgct 47460 ccactctccc agtaccaatt ttctgtatta gctcattctc atactgttat aaagaactac 47520 ctgagactgg gtaatttatg aagaaaagaa ctttaactga ctcacagttc tgcaggctta 47580 acaggaagca tagctaggag gtctcaggaa acttacaatc atggtggaag gcaaatggga 47640 agcaagcacg tcttaccagg gcagagcagc agagagagag agagagagtg agaggggaag 47700 tgccaccact tttaaaccat catatctcct gagagctcac tcattatcac aacaacagta 47760 tgggggaaat gtgcccccat gatccaatca cctcccatca ggtccctccc caaacattaa 47820 gaattaaaat tcaacgtgag atttgggtga ggacacagaa ccaaaccata tcaggcattt 47880 agaccattta cgttcaaggt taatttttat atgtgaggtt ttgatccctt gtttagttgt 47940 tagctgtttg ctttgttgtt tctattgtgt ttttgctttg tagggtgtgc aggctatgtg 48000 cttaagtgtg tttatgtgga agcaggtatg gttcttttgc ttccatgttt agaactccca 48060 tgtaaggatc tcttgtaagg atggtctagt ggtaacaaat tcctttagca cttgattgcc 48120 tggaaaagat tttatttgtc ctgcacttat gaagcatagt ttggcaggat gtgaaattct 48180 tggttgaaat ttcttttaag aacgctgaaa acaggccccc aatctctcct agcttgcaaa 48240 cctctgctga gaaatctgtt attatcctga tagagttccc tttttatgtg atctgcactt 48300 ttctctggct gcctttaaga ttttttctgt aatattgcct ttgaacattc tggtgactat 48360 ataccttggt gatttttttt tttttgagat ggagccttac tgtgtcacac aggctggagt 48420 gcagtggtga gatcttggct cactgcaacc tccgccctcc aagttccatg gattctcctg 48480 cctcaacctc ccgagtagct gggattacag gtgcctgcca ccgtgtctgg ctaatttttt 48540 gtatttttag tagagtcagg gtttcaccgt cttggccagg ctggtcttga actcctcacc 48600 tcatgatcca cctgcctcag cctcccaaag tgctgggatt acagacatga gtcaccacgc 48660 ccagccagtg atgttcatgt ttgtggtgtc tcacagatgt tctctggatt tctagctctc 48720 tagcaagatt aggaaagttt tcttgaatta ttccctcaac tatattttcc agtttgtttt 48780 ctttttctcc tactttctga ggaatgccaa taattcatag ggtttttttg ctttatataa 48840 tcttatattt ctcaaaaaca gctcatttaa aataattttt ttctttattt ttatcagatt 48900 gggttagttc acaagaccag ccttcaagct ttaaaatttt ttcttctgct tgatccagtc 48960 tattgataac gaatttcaaa atataattga aggctttaag tgagtttttc aattccagaa 49020 gctactattg atttttttta agatgttcat gtctttctta atttcctaga ttgctttaga 49080 agtttatgtt ggttttcaac cttgtctttg attacaatga acttccttgc aatccatgct 49140 ttgaattatt tatgtgtcat ttctgagttt ccatcttggt tagggaccat tgctggaaag 49200 ctagtgcaat cccttagtga tgtcactgca atcagatttt tcattatgcc agaattcttg 49260 cactggtttc ttctcatctg gagacattgg cacttcaaat ttttgtactt attttcatgt 49320 gggtagtagt ttttcttttt tttttctttc cctataatgg tattattatt attattttaa 49380 taattttttt tgtttccctt ttaccccttt tctagggctt gtgcctctaa agaatgctgg 49440 gtaggatctt ttcactttga ttctacagcc ctatgtgctt ctttcagcag gttttatact 49500 gggctctgca ggtcatccca caggcccata ggcggcacgt ataggtaaga gctggctgtg 49560 accaatgtgg ctggatatat acttgatcct tgtttccgag caaaagctct ccattgtctt 49620 aggcaatagg ctgattctga ttcatagaat gcacagtagt tggaactccc tgctcagccc 49680 caaggagaag ggaaccacaa agggcaagtt tggaccgagc aggtccacct gcgtcccctg 49740 atggcaagca caagcaccag tgccaaggaa gaatccagtg ggtggccacc aagcacccag 49800 agttgtacac agacctgaag cttggaaacc tcctcagctg caaattctct gcatgggagg 49860 catcctaagc tcctgattca ggagagtggg tgctccagat gcctggagat ctgctttggc 49920 atggaataga gaggggcccc ctgcaccaag atctctacac aggaggggta aatgacaatt 49980 atatatagtg ctgcaggaaa catgtgaatg cagataatat cttcaatata ccagttttct 50040 ttcttttggc tatatgccca acagtaggat tgctgcatca cgtggtagtt ctgtttttag 50100 ttttaggaac ctccatactg ttttccatag ttacagtact aatttagatt actaccaaca 50160 gtgtacgaga atttctcttt ctccatatcc tcaccagcat ttattttttg tctttttagt 50220 aacagccatt ttaactggag tgagataata tcttattgtg gttttatttg catttccctg 50280 atgattagtg atgttgagca ttttttcata tatctgttgg catttgtatg tcttctttca 50340 agaaatttct gttcattttg cctattttta aatgggatta cttttttttt ttgctattga 50400 gctgagttcc ttatatattc tgataattaa ctccttgtca gatgaatagt tttcaaatat 50460 tttctctcat tctttgtctc ttcacattgt taactatttc ctttgctgtg cggaagcttt 50520 ttagcttgat gaaattccat ttgtcaattt ttgccttgat tgcctatgcc ttgaggtctt 50580 actacaaaaa tatttaccca aaagtcttaa agcagttccc caaagttttc ttgtagtagt 50640 tttgtagttt cagatcttac acttaagtct ttaatcgatt ttgattttat tttcgtatgt 50700 ggtgagtgat agtgatctag ttctgttttc tgcatatagg tagccagttt tcccagcagc 50760 atttattgaa gagattgccc tttccccaat gtatatccat ggcacctttg tcaaaaatga 50820 gttgactgtt aatgcatggc tttatttctg ggttctctat tctgttccat tggtctttgt 50880 gtctgttttt ataccaatat catgctgtta tggttaagaa ttctcatttc tgacatagag 50940 accatttaaa taacaaaaga taaaacatga gagaatatta gaaagctttt aaaagattta 51000 ataaaatctt acagtagaat aatagaggta ataaatatgt tttgacatgt catgacatag 51060 attttgttag gagcagtttg ttcttatctg cttccgtggc tatgttttga ttataaaaat 51120 tatgttttga gttatttgat ttcttcgttg catatgattc ttgtctttaa tgaatcactt 51180 ccctaccttg aacaggtcac agtgaacttt tgctttagtt cactgctgta cagcactgag 51240 tgggaagata gttacaccct taaggatgat aatatatctt ctactttagg tgttctgctt 51300 ccatcttctt tcttctagaa aacatttttg tttaatgact cacaaaaaaa tatctgaaat 51360 gaatacagct ttatattttg cagttgtaaa aatgctaaac tagtataagg taattagctc 51420 tttcaaaaat aagtcgcttt ctacataaaa gaatgattaa atgaatagtt atcttctttg 51480 aaatttttta aatccacagt tacaggtttt atgggttttt ctttttttct attattttct 51540 tttttggtag caagccttat cttcacattt taaaaggttg tgttagaaag ccagtttctc 51600 tccttctccc cctacctcct cctccaccta gattcaacca cttcttatgg caaagagaat 51660 aactttctgg gctagagagt atgggttgtg tagtaaagat ttttgttgtt tttttgtttt 51720 ctcctcctac acttgacagc caacaaggct acaagtcttc tttggaagaa ctgcaaaatt 51780 cttgaattta ggacacagtg gtatcttttc tagaagtaca gagtcctgct ctgtgccttt 51840 aataccctaa gaacaaaaat catttttcct ctttaaggca agatctactg tgggtgatgg 51900 ctaccaccta cctctctaga cctcacagaa tcttcttctt aatgggcatc tctttttcca 51960 cccaaatcct ggcctttgaa tcagcatctc tcagagacag cacctctcac attgctcccc 52020 aagttcactg cattggagcc tgcagccaac tgatgtcctt ctcatcagtc tggttgttta 52080 ccctaaacac catctcacac atgctagctg gggatggtcc tcagactatt cattctcatt 52140 tctttgctta aaatttttct gtgtttgtat gggatgtctt ttatggtttg ccaactagaa 52200 cttttcagta gtatctacaa gcatttatta ttttctagac tcagtaaaaa gttagaattg 52260 aggggttcaa atatctcctc cattgtagtt gactttattt gaatgattaa gacatataca 52320 tttaaaaaaa tcaattctag tatagttttg gtttttggaa aatacctgat ttcactttat 52380 atttcctgtt gtctagcatc tttgttttct ttgaagtata tacaaaggca cactgtgttt 52440 tgatctggaa attggaggtg aatcctgaaa aatggaaggc aagcactatc agtgctataa 52500 aggattgtta aagtgtagtg ccagtggact gatcccagca ctgcgcagtg gtcattatca 52560 ttttggtaat ctgaagtaga agcatgcctc tagacatcct tccataattt tatataggta 52620 gtgtaaggat gactgtctat aaattcacct gaactacaga gagacttctg atataataaa 52680 agaaaaatac agagattgtt caggatggga atacaaacac taggaaactg gaaaagcaaa 52740 ttaaaacttc tgaattaata gaaaaagtta aataggaaag agaaaataaa gggaaacttg 52800 accaaggtag caaagaaaga aaatggaaaa gaggtaatta tgaggcagta taaaacaaac 52860 tctgtcgcaa aaaaaaaaaa aaaaaaaaaa aaaattccat ttgtagtttt aaaaaaatag 52920 taaagatata gaaaaattag tagaaaatac aaaaatctgt attcttcttt tatcagaatt 52980 aaataattat gcctgcccta ttttaccaaa ttattttatt aaaacatgct aaagaagttt 53040 ataagctttt cttctccctg ctcccattct ctataggatt tttgctgaga tatttcaaaa 53100 tttttatttt taggttatat ttaagctttc acttctaatc tctctcaaaa acctttcata 53160 tcacttgtca taaaaatttc ttctcatagt atcatcatcc agattcagtc acatatacat 53220 caagaataat tgtgcaatac tgtttcctag actcttcatc ttatcttttc aatgcatgat 53280 atttaaataa gccatacttt ttaatgtttt caatttttta atttatattt atttatttca 53340 aattttttat tatattttaa gttctgggat acacgtgcag aacgtgaagg tttgttacat 53400 aggtatacac gtgccatgat gttttgctgc acccatcaac ccatcatcta cattaggtat 53460 ttcttctaat gttatccctc ccttagcccc ccaccccccg acagatccct gtgtgtgaca 53520 ttcccctccc tgtgtccatg tgttctcatt gttcacctcc cacttatgag agaacatgca 53580 gtgtttggtt ttctgttctt gtgttagttt gctctgaatg atggtttcca gcttcatcca 53640 tgtccctgca aaggacatga actcatccct tttgatagct caatgttatt gcatggtgta 53700 tatgtgccac attttcttta tccagtctat cattgatggg catttgggtt ggctccaaat 53760 ctttactatt gtgaatagtg ctgcagtaaa catacgtgtg catgtgtctt tatggtacaa 53820 tgatttataa tcctttgggt acatacccag taacgggatt gctgggtcaa atggtatttc 53880 tggttctaga tccttgagga atcaccacac tgtcttctac aatggttgaa ctaatttaca 53940 ctgccaccaa cagcgtaaaa gctttcctat ttctccacat cttttccggc atctattgtt 54000 tcctgagttt ttaatggtca tcattctaac tggcatgaaa tggcatctca ttgtggtatt 54060 gatttgcatt tcgaccagtg atgatgagct tttttttcat gtttattgcc cacataaatg 54120 tcttcttttg agaagtgtct gttcatatcc tttgcccact ttttgatggg gttgtttttt 54180 gttttttttt ttgtaaattt gtttaaattc tttgtagctt cttgatagta gtcctttgtt 54240 agatggataa attgcagaaa ttttctccca ttctgtaggt tgcctgttca ctctgatgat 54300 agtttctttt gctgtgcaga aggtctttag tttaattaga tcccatttgt caattttgtc 54360 ttttgttgcc attgcttttg gtgttttagt catgaagtct ttgcccatgc ctatgtcctg 54420 aatgatattg cccaggtttt cctctagggt ttttatggtt ttcagtctta catttaagtc 54480 tttgatctat cttgagttaa tttttgtata aggtgtaagg aaggggtcca ctttcaattt 54540 tctgtatatg gctagccagt ttccccaaca ccatttatta aatagggaat cctttcccca 54600 ttgctttttt ggtcagattt gtcaaagatc agatggtaga tgtgtggcat tatttctgag 54660 gcctctgttc tgcttcattg gtctatatat ctgttttggt accagtacca tgctgttttg 54720 gctactgtag ccttgtagta tagtttgaag tcagctagcc tgatgcctcc agctttgttc 54780 tttttgctta ggattgtctt ggttatatgg gctctttttt ggttccatag gaaatttaaa 54840 gtagtttttt ctaattctat gaagaaagtc aatgttagct tgttggggat agcattgaat 54900 ctataaatta ctttggtcag tatggccatt ttcatgatat tgattcttct gatccatgag 54960 catagagtgt ttttccattt gtgtcctctc tgatttcctt gagcgttgat ttgtagttct 55020 ccttgaaggg gtccttcaca tttctcgtga cttgtattcc tagctatttt actccttttg 55080 tagcaattgt gaatgggagt tcagtcatgt ttgggctctc tgtttgtcta ttattggtgt 55140 ataggaatgc ctgtgatttt tgcacattta ttttgtatcc tgagacttca ctgaagttgc 55200 ttatcagctt aaggagattt tgggctgaga tgatggagtt ttctaaatat acaatcatgt 55260 cctctacaaa aagacacagt ttgacttcct ctcttcctat ttgaatacgc tttatttctt 55320 tctcttgcct gattgccctg gccagaactt ccactactat gtttaatagc agtggtggga 55380 aaggacatcc ctgtcttgtg ctggttttca aagggaatgc tttcagcttt tgcctattca 55440 ttatgatatt cgctgtgggt ttgccataaa tagctcttat tattttgaga tacggtccat 55500 caatacctag cttattgaga gtttttagca tgaaggggtg ttgaattttg ttaaaggcct 55560 tttctgcatc tattgagata atcatgtggt ttttgtcatt ggttctgttt atgtgatgga 55620 ttacgtttat taatgtgcgt atgttgatcc aggctttcat ctcagggatg aaactgacct 55680 gatcatggtg gataagcttt ttgatgtgct gctggatttg gattgccagt attttattga 55740 ggatttttgc atcaatattc atcagggata ttggcctgaa attttctttt ttgttgtttc 55800 tctgccgggt tttggtgtca ggatgatacc aaataaaatg agttagggag gattccctct 55860 ttttctattg tttggaatag ttttagaaag aatggtgcca gctcctcctt gtatctctgg 55920 tagaattcag ctatgaatct gtctggtcct ggggtttttt tggttggtag gctattaatt 55980 actgcctcaa tttcagaact tgttattggt ctattcagga attcaacttc ttcctggttt 56040 catcttggga gggtgtatgt gtccaggaat gtatgcattt cttctagatt ttctagttta 56100 ttttcataga ggtgtttata gtattctctg atggtagttt gtatttctgt gggatcactg 56160 gtgatatccc ctttatcatt ttttattgtg tctacttgat tcttctctcc cttctttatt 56220 agtctggcta gtggtctatc tactttgtta atcttttcaa aaaaccagct cctggattca 56280 ttgatttttt ttttttaagg gtttttcatg tctctatctc cttcggttct gctctggtct 56340 tagttatttc ttgtcctctg ctagcttttg aatttgtttg ctcttgcttc gctagttctt 56400 ttaattgtga tattagcgtg tcaattttag atcattccca ctttctcctg tggacattta 56460 gtgctataaa tttccctcta aacaaacact gctttagctg tgtcccagag attctggtat 56520 gttgtgtctt tgttctcatt ggtttcaaat aacttattta tttctgcctt aatttcatta 56580 tttatgcagt aatcattcag gagcaggttg ttcagtttcc atgtagttgt gcagttttga 56640 gtgagtttct taatcctgag ttctaatttg attgcactgt ggtctgagaa actgtttgtt 56700 attatttcca ttctttcaca tttgctgagg agtgttttac ttccaattat gtggtcaatt 56760 ttagaataag tgcaatgtgg tgctgagaag aaggtatatt ctgttgattt ggggtagaga 56820 gttctgtaga tgtctcttag gtccacttgg tccagagcct gagttcaagt cctggatatc 56880 cttattaatt ttctgtcttg ttgatctgtc taatattgac agtagggtgt taaaagtctc 56940 ccccattaat gtgtgggtgt ctaagtctct tcataggcct ctaagaactt gctttatgaa 57000 tctgaatgct cctgtattga gtacgtattt ttaggatagt cagctcttct tgttgcattg 57060 atccctttac cattatgtaa tggccttctt tgtcttttga tctttgttgg tttaaagtct 57120 gttttatcag agactaggat tgcaacccct gcctttttta gctttccatt tgcttggtaa 57180 atattcctcc atccctttat tttgagcata ttgtgtctct gcctgtgaga tgggtctcct 57240 gaatatagca caccaatggg tcttgactct ttatccagtt tgctggtctg tgtcttttaa 57300 ttggggcatt tagcccattt acatttaagg gtaatagtat tatgtgtgaa tttgatcctg 57360 tcattatgat gctagctggt tattttgccc attagttgat gcagtttctt cctagcatcg 57420 atggtcttta caatttggca tgtttttgca gtggctggta ccggttgttc ctttccatgt 57480 ttagtgcttc cttcaggagc tcttgtaagg caggcctcgt ggtgacaaaa tctctcagct 57540 tttgcttgtc tgtaaaggag tttatttctc ctttgcttat gaagcttagt ttggctggat 57600 atgaaattct gggttgaaaa ttcttttctt tagaaatgtt gaatattggc ctccactctc 57660 ttctggcatg tagggtttca gcagagagat ctgctgttag tctgatgggc ttccctttgt 57720 gggtaacccg actttctctt tggctgccct taacgttttt tccttcattt caatcttggt 57780 gaatctgaca gttatgtgtc ttggggttgc tcttctcgag gagtatcttt gtggtgttct 57840 ctgtatttcc tgaatttgaa tgttggcctg tcttgctagg ttggggaagt tctcctggat 57900 actatcccga agagtgtttt ccaacttggt tccattctcc ccgtcacttt caggtacacc 57960 aatcaaacgt aagtttggtc ttttcacata gtcccatatt tcttggaggc tttgtttgtt 58020 ccttttcatt ctttattctc taatcttgta ttcatgcttt atttcattca gttgatcttc 58080 aatctctgat atcctttctt ctgcttgata aatttggctg ctgatatttg tgtatgcttc 58140 acacagttct tgtgctgtgt ttttcagctc catcaggtca tttatgttct tctctaaaat 58200 ggttattcta ggtagcaatt cctctaacct tttttcaagg ttcttagctt ccttgcattg 58260 ggttagaaca tgctccatta actcagagga gtttgtcatt acccgcctcc tgaagcctac 58320 ttctgtcaat ttgtcaaact cattctccgt ccagttttat tcccttgctg gtgaggagtt 58380 gtgatctttt ggaggagaag aggcattctg atttttggaa ttttcagcct ttttgcactg 58440 gtttttcctc atcttcatgg atttatctac ctttggtctt tgatgttggt gaccttcaga 58500 tggggttttt gtgtggacat cctttttgtt gatgttgatg ctattccttt ctgtttgtta 58560 gttttccttc taacagtcag gcccctctgc tgcaggtctg ctggagtttg ctggaggtcc 58620 actccagacc ctgtttgcct gggtatcact agcggactct gcagtacagc aaagattgct 58680 gcctgttcct tcctctggaa tcttcatccc agcagggcac ccaccagatt gccagccaga 58740 gctctcctgt gtgaggtgtc tgtcgacccc tgctgggagg tatctcccag tcaggaggca 58800 caggggtcag ggacccactt gaggaggcag tttgtccttt agcagagctt gagcactgcg 58860 ctgggagatc cgctggtctc ttcagagcca gcaggcagga acgtttaagt ctgctgaagc 58920 tgcgcccaca gccacccctt cccccaggtt ctctgtccca gggagatggg agttttatgt 58980 ataagcccct gactggggct gctgcctttc tttcagagat gccctgccca gagaggagtc 59040 tagagaggca gtctggctac agcagctttg ccatgctgca gtgggctctg cccagtttga 59100 agttccaggt ggttttgctt acactgtgag gggaaaactg cctactcaag cctcagtaat 59160 ggtggacgcc cctcccacca ccatgctcca gcgtcccagg tcgacttcac actgctgtgc 59220 tggcagcgag aatttcaagc cagtgaatct caacttactg ggctctgtgg ggatggtatc 59280 tgctgagcta gatcacttgg ctccctggct tcagcccccc ttccagggga gtgaatggtt 59340 ctgtctcact ggcattccag gtgccactgg ggtatgaaaa aaaactcctg cagctagttc 59400 attgtctgcc caaatggctg cccagttttg tgcttgaaac ccagggccct ggtgatttag 59460 gcacccaagg gaatctcctg gtctgtgggt tgcaaagacc atggggaaag catagtatct 59520 gggccggaac acattgttcc ttacagcaca gtcactcacg gcttcccttg gctaagggag 59580 ggagtttccc cactctttgt acttcccggg taaggcaatg ccccaccctg cttcagctcg 59640 ctctccatgg gctgtagcta ctgtctagcc agtcccaatg agatgaggtg ggtacctcag 59700 ttgaaaatgc agaaatcacc caccttctgt gttgatcgcg ttgggagcta cagaccggag 59760 ctattcctat tcagccatct tgccagccag caaccactct actttttttt tttttaattt 59820 aagttctggg atacatgtac agaatatgca ggtttgttac atagatatac atgtgccatg 59880 gtggtttgct gcacccaaca atccatcatc tacattagat gtttctacta gtgctatccc 59940 tcccctagct ccccacccct caacaggccc tggtgtgtga tgttcctctc cctgtgtcca 60000 tgtgttctca ttgttcacct cccacttatg agagaatatg cagtgtttgg ttttctgttc 60060 ttgtgttaat ttactaagaa tggtttccag cttcatccat gtccctgcaa aagacatgaa 60120 ctcatccctt ttgatggctg catagtattc catggtgtat atgtgccaca ttttctttat 60180 ccagtctctc actgatgagg atttgggttg gctccaagtc tttgctattg tgaatactgc 60240 tgcagtaaac atacatgtgc atgtgtctta tggtacaatg atttataatc ctttgggtat 60300 atacccagta atgggattac tgggtcaaat ggcatttctg gttctagatc tttgaggaat 60360 catcacactg tcttctacag tggttgaact aatttacact cccaccaaca gtgtaaaagc 60420 tttcctattt ctccacatcc tctccagcat ctgttgtttc ctgacttttt aatgatcgcc 60480 attctaactg gtgtgagatg gtatctcatt gtggttttga tttgcatttc tctcatgacc 60540 agtgaagatg agcttttttc catgtttttt ggccacataa atgtcttctt ttgagaagtg 60600 tctattcata cccttcaccc actttttgat gttttttttt tcttgtaaat ttgtttaagt 60660 tccctgtaga ctctggatat tagccctttg tcagatggat aaattgcaga gattttctcc 60720 cattctatag gttgcctgtt cactccgatg atagtttctt ttgctgtgca gaaggtcttt 60780 agtttaatta gatcccattt gtcaattttg tcttttgttg ccattgcttt tggtgtttta 60840 gtcatgaagt ctttgcccat gcctatgtcc tgaatggtat tgcctaggtt ttcttccaag 60900 gtttttatgg ttttaggtct tatgtttaag tctttagtcc atcttgagtt aatttttgta 60960 ttaggtgtag ggaaggggtc cactttcagt tttctgcata tggctagcca gtttccccaa 61020 caccatttat taaataggga atcctttccc cattgttttt tttggtcagg tttgtcaaag 61080 atcagatggt tgtagatttg tgacgttact tctgaggcct ctgttctgtt ctattgttct 61140 atatatctgt ttgggtacca gtaccatgct gttttagtta ctgtagagtt gaagtatagt 61200 ttgaagtcag gtagcatgat acctccagct ttgttctttt gacttaggat gtcttggcta 61260 tacaggctct tttttggttc catatgaaat ttaaagtaat ttttttctaa ttttgtgaag 61320 aaagtcaatg ttagcttgat ggagctatta ttggatctat aaattacttt ggtcactatg 61380 gccattttca aaatatacat tcttcctatc tatgaatatg gaatgttttt ccatttgttt 61440 gtgccctgat ttccttgagc agtgttttgt agttctcctt gaagaggccc ttcacatccc 61500 ttgtaagttg tattcctggg catttaattc tctttgtagc aattgtgaat gggagttcac 61560 tcatgatttg gctctctgtt tgtctattat tggtgtatag gaatgactgt gatttttgca 61620 cattgatttt gtatcctaag aataagccat actttttaat atattttatt cataaaaaaa 61680 tgcacataaa gcaaatgaca tatagaaaca atatgattaa catccacctc tggactcagt 61740 tggcttaaga aaatatgaat attatcacta cacttgaaat tgattgcata tttcttcctt 61800 atcacattcc tctttatctt tctccagaaa cctctatatc tttaatttgg agttggtcat 61860 tttcttatat tattctgtag gattttttaa tatctatgta tttctcacta atagattttt 61920 tagttttgag atgttttttt ctactccata gaaatgctat gtatatttat gcaatttgat 61980 cttactgcct aatattatat ttgtgttttt tattttgatt tgtattattc tggtttgttt 62040 tttcctacac tgtatgattt cattgtatga gtatctccca tttatttatt ctcatgtatt 62100 gacatgtact tccacttgat atttgctgtg ctttacctac agttcaattg tgaacattat 62160 tttacatgta ttctggtggt tcatgtgtga gagtttctgt aggtaacctg cacacctggg 62220 catgaaattt ctgactgtaa tacatgctca tgctgggctt tactagataa tgctagattg 62280 tttttaaagt agtagtagtt tacactccat ggcagctctt cattgttttg tgtgttcctg 62340 tattctgtgt ccttgccgtt ttaggtagat gatgtctcat gtggtcttac tttgcatttc 62400 tctggttaat aatgaggtca gtcatattgt tgtattttgt catctatata tttcttcctc 62460 tgtgaaatat ctgttcatgc cttttctttc tgatttatag gaattctttg tgtattttgg 62520 gtatatatgt tataaatatc tataggatag ataaaaacaa gctatctgat aaggcgatat 62580 gcagaaatat aaattaggtg aggaagcaag ccatgcaaat atccaaggaa aaaatcattt 62640 catgcagagg aacttgtcag tgtaagaccc caaggcagaa acacacttca agggcaagat 62700 gggcatcaat atgggtggag catgagggag aatagaagag agaccatcta tgcaagggta 62760 agttgggcct tgtagagctt gatatgaatt ttaacttcat tctaagtagg atcaggagtc 62820 actgaaaata tcaagcaaga atgacatagt ctgattaagt ctttaaagtt gtatagaaaa 62880 tagtctacaa aaagtgaaag ctgggaaacc agccagcata tgttacaata gtccaactgt 62940 gattgtgggg acataaatta tggtgcaagc agtggaaaca ggtatttgga tttgggttat 63000 attttcatgg ttatccacta ggatttgctg atgtattaga tatgaggtga gaaaataagt 63060 gaggtatcag taatgactct agagtttggg gctagagcag caggtgtgta aatgaagtta 63120 caaacctaga agatgcatgt ttggaccaat gcatcaaagt tctgctctaa acatattaat 63180 ttgaggggtc tgttagaaat acaagtggag atgctgagaa tacagttgca tagttgagtc 63240 tagagtttct tggaaaagct gggtctagga ctgtaaattt ggtaatcatt aatgtctaga 63300 tgatattaga gacatagaac tagatgcaga cacctagaaa gagcatagat atctaagaga 63360 agtctgagga ctgagcttgg tgtactcaaa gatttagaag ttgagaagat gaaaaagagc 63420 tagacagaga gactgaaaga gtgactacaa gaatgaaata tgtggaagcc aaatgaataa 63480 gagcgttaaa agaagaagga aacgatcaat gtgttaagta cttacccggg ttaagaccag 63540 gactgagaat tggccattgt tttttgacat ttagaaatct ttgaaggcct tgccaagaat 63600 aatttggttg ggataaggag aggaatgacc tgactggaga aggttcaagg gagaattgga 63660 ggagaggaaa tgaagagagt gatatttctc cacggaatac attatgtgtg agagggacta 63720 ttagaggatg cagacaagag ggcaaatgat ttcagagaaa agtccctgag tgggtgagaa 63780 ggactaagat ttggtattga aatgtcagga gtatgaattg taacaggagg gaaggcagag 63840 tacaggggta gccatactgt agattggcca caaagaaaat attctccaaa tggagcttct 63900 ttccccctaa gcctccccca aatcattacc tctgcttctg attcaatccc tcaaaacctc 63960 atccatcagc ttgaatgaga gacaactatt cagccaccat gtccatccgc tttcttatcc 64020 ccccttgctc acccccagcg tctcagccca aatcttccct ccttccagcc aacaaagctc 64080 ccatgcctgt catctcctga tgtcaatgca gcgggcaggg gagtggggga ccactgaccc 64140 cacatgccta ttctctgctt agattaccca aaataccagg tgtcgttatt tttcagaggt 64200 gcaaaaatat aatacaaagt cattctaaac tgtcactgaa ttcagagtac tttttgccat 64260 tgtctagtca ctgaattcag agtacttttt gccattgtct tattttctca atcaacaaat 64320 gctaagagta caattatatg aagttctaca gatttatttg ttacttgcat tacttagtaa 64380 tggttcttat gcataaaggt taggaataac ttctttgaac aaatatccta tataaaaaaa 64440 caacaaagtg gtttttaaaa atcacattgc tgttcacatt ccctttttag tactctcttc 64500 tcatattctt ttttaagcta tgttaggtca aaacaactac tttaataact tagcaaatat 64560 ctatcaggag tccactgtgt agttagcagt ttataaagct tcagatctac attagtgagt 64620 gaaatggacc tagcccctat ccttacaggg cagcaagcct ggtggaggaa gctatgttct 64680 ctgaaggcaa caaaaacagt catgcgtcat ttaagagtag ggatacattt tgagaaatgt 64740 gtcatgaagt agtcaatttc atcattgaac atcatagaat gcatttacgc agacttagat 64800 ggtatagcct actacacacc taggctgttt ggtgtagccc attgctcctg ggctacaaac 64860 cgatacagca tgttactctg ttgaattttg taggcaactg taatgcaatg gtaagtattt 64920 gtgtacctaa acatatctaa agatagagac agtacagtaa aaaatactat cttatgaaaa 64980 cactgttgta tatgtggtct gtcattgact gaaacaatat tatgtagtgc aaaccataca 65040 gcaacagata ataaagacaa gatattcaga gtgggagatg gaaaagacaa taatgtattc 65100 cttcattcat ttagcagaca tgtattgcca aaagacactg gaaaaaataa ataaaggtga 65160 caaacaggtg gtgcctttgt tgaagattat agtcatggac agggaaactt tagccctctt 65220 cttaacatta tcttccctta gacacaaaca cacacacaca caattcctgg catatgctat 65280 atactccata actgttcctt cccttccctt tgtgactcat tccttccccc agaaagctca 65340 tttgatctct gcaaataatt ttgaatcccc tttgtttttt aaccatggca attgttttgt 65400 tttcccatct cctacaagtt ttagctcaac tcgttggggc tgtttttttt tttttttttt 65460 tttttttttt tttttttttt ttgaggtgga gtttctccct tgtcacctgg gctggagtgc 65520 aatggcatga tcttgactca ctgcaacctc tgcctcctgg gttcaagtga ttttcctgcc 65580 tcagcctctg gagtaactgg gattacaggt gcccaccacc acacccagct aatttttgta 65640 tttttagtag agacggggtt tcaccatgtt ggccaggctg gtctcgaact tctgacctca 65700 ggtaatctgc ccacctcggc ctctcaaagt gctagaacta caggcatgag ctcaccatgc 65760 ctggccattc cttggggctt tatagaacaa gtataatcct ttttctttat gacaataccc 65820 tgagttcaga aatctcagag acaaatgttt acagagacca ggtaaataag tagctagagt 65880 gacaagactt aagaaaagag accattggcg taccaccagt ttgtggaggg aactggaaaa 65940 actggaatac acatgcccca tccaaaagca accattgcaa ctaaacttta acagattgtt 66000 gccacctaag taattcacgg atggtctcat aattctggtc agcattgtct gagccaaaca 66060 aaatgtatct atgggcatga tcagatacta gagccagcag attgcaacct ctgcttagat 66120 aattgcaggt atcagccttc ccttggctaa acagctactt catactgata agtagccctt 66180 gcctggcaca aagcaggtgg ggctgaatcc agcctgatat cacatcacca caactttctc 66240 taattctcct caaggcgtct gtgaactacc agcagcccaa ataagcatcc ttttctcctt 66300 caatcatttc tcataaagca gattctactc atctcaccat ccatcttttt cccctaacat 66360 atcagaattc atcaaagtag aaactccaga aatcatccag aaatacaaat gtgatctgac 66420 cagcacgggt ataaactttc tctttcctta atttagaaaa aggattatta attttgagtc 66480 ttagatctca taaaagtaga gctggattga ttttaaggga tcaatgaacc tactgaaatt 66540 gtataaaaag attttgtggg gctggcaaac aaatgctttt cttttaacat attcttaaaa 66600 gaacaaaacc tcaaagaaga tttaacaacc actatagact aagtttcaat taatgtagtc 66660 tgtagcatta gattttggaa ggctgttcta tcagaatatg gaccaatact gagcgtagtc 66720 gctactaaaa ctctttgtct ttttattcat atcttctcct aaaaagctcc atgacccctg 66780 cagaatactg gtataattac ccacacctca cccacccagt gattgttgat gtaactaatt 66840 atttaatcca agtctgaggc ctaaattttt tttaatcaag agttagttac atgttttaat 66900 ttattttttg taattttaat atctaacact tttattctat ttcattcgat tgatgctaaa 66960 atgcataatg ctatgattct aagacttagg aaaaataata ctatactggg atatggagtt 67020 tatatatatt tacatgaatt tctttttttt cttctctgta ggtcgaaaat ttaaaaagtt 67080 caataaagtc agagttgtga gagcactgga tgctgttgct ctcccacagc cagtgggcgt 67140 tccaaatgaa agccaagccc taagccagag attcactttt tcaccaggtc aagacataca 67200 gttgattcca ccactgatca acctgttaat gagcattgaa ccagatgtga tctatgcagg 67260 acatgacaac acaaaacctg acacctccag ttctttgctg acaagtctta atcaactagg 67320 cgagaggcaa cttctttcag tagtcaagtg gtctaaatca ttgccaggta ataataattt 67380 ttatatacag catgtaataa aaaatatact atgtttgttg tattagtaca ttgttaaata 67440 aaacactcta tgcagtaaat taactacaat ataaaacagt atgtgatagt atgtgtttga 67500 gcagttcaaa atatttgtct aggaccctaa tatgtgttac agaaatataa aaaattagag 67560 aacacactga gtcttactga tgagtcagaa attgcataca ttaaacttat gctaataaga 67620 aatagcttag gtttatgtgt tcaaccacag atattagagt agctcagaaa tgataaatgg 67680 accatttttt ataaatgccc tatttattct aacccttaat tcaaccaacc tcatttggtt 67740 gaaaataaaa ctgaatgtat aaagtcatat aacaaatcaa agtagtattc agagtacagt 67800 aaggtgtcaa aagtaaatta agaaaacaaa attccctaac gtaaattact ttaaaaaata 67860 atagcacaca gagaaaagaa tctctagtca ctattcctct aatttatacc caaagagagt 67920 atatcgccca gcaacagaga gaacttggat tatatcatca cagaagaatt tcagtcactt 67980 tacttatcag ctatttttgc tccctcagca cagctctgta ggagccaagt acttgaaaga 68040 ataacaagga tgaaattctc acttggttaa atcttagact gcagagccag gagaatacat 68100 gtatagcaat tgtttgtgaa ggcattactc ctataattag aaatagaact ttttaaaaaa 68160 ctacattctc ttcacatcag taataccctt atactgctat agacaaatta tttttctaat 68220 atctgatcaa gaattaaaca tattatgtcc ttttagtccc caagtaaatt caatggcact 68280 tttagaaaaa gaatttcttc ccaattctcc ttaatataat tctcagttat tattctacct 68340 aaaaggtttg aaatacaata gatgaattgt tactgaaaat tcaattacat gaaacagaaa 68400 gaaaaataga tacctgtttg ttgaatcttt caaaaaatac atattaagaa aagttaatag 68460 aattcagtat tctagtggag atgaagtaat tttatagaaa aatcaaaatg cccagattct 68520 tactggcttc agtctcacca aaaggcctta aacagacaat aattttttga acattctaaa 68580 tgtttaagat ttatcacata gtggttatca aacttgacag agctttaata aataaaaata 68640 acccaatagc attgatgaac tttttctgtt taaaaatgag tgtttaaaca tgtgtttaat 68700 ttttctccat tgttctatta tttggaaaat atgatttctt tggtttttgt tgatatagtt 68760 tatattcctt ttgtttgcaa ttttggaggt tctttactat ttaaaaagat tctagcatca 68820 gctggtaacg ttagaaaata accagttata cttgaaaaga tgacttattc actttggata 68880 aaagctaagt gaccttttta accggaaacc gttatctatc aggacttttt gacccccaca 68940 caaccacaaa aaggaatgag agaaaactct tacattgaat ttggtggcaa cttttttaat 69000 gctgcaaaat gtaatttttg tgtagtaaat cagaataatg gcaacactag tattacccat 69060 actgtttcca ttaattgcaa acagggaaac attgagatta tcaaagtctc ttgtggcctg 69120 tggactttta aagccatatt ttcatggtct gcattttggg aatagcacta ttgaatgaat 69180 tatgaaaatg gtcagtgagc tagagtgact atttgacctc tgagaaagga cttggatgga 69240 cacatgtata gaaagtactt tagtattatt agctacttaa aactgatttc aattgacttg 69300 aaataagctt acagttttta ttcacttatt cactcaataa atgtctatta tgtacctgct 69360 gtgttcaata tctaataatt atacagtggt ttagaaagaa aagccacaag gctgggctca 69420 tggtgtggat gcattttggt acagcacatg ctagcatctg gtcatcagtt ttgcatgtaa 69480 aagaaattta tttcgttcat tcactcatgt gtaataaaac taataagtct gtggaagaca 69540 gacttttgtt aagtgatcct cactaattag ccagaatgtc aactaacttg cttatttaca 69600 gtgagacaca cacacacaca cgcacacaca cacaatataa atatacataa tacttatgtt 69660 gctaggagaa tatattaaca gatcagatca ttctttcaca ataggaaact gtatttggaa 69720 agtcacatta agatctgatg cagaatgacc atcataacaa aggtgacagc gtttatgaag 69780 acacctaggc atatatttgc aggtgcccta agaattctta ttgcctggta gggctttctc 69840 atttcttctt tgtctacact cttccattat cttggatctg ttataataat ggtagtttat 69900 atttcttcaa aaatatttca gatatatcct tttgtttctt ttcttttttt tctttttttt 69960 tttttttttt tgagagaggg tctcactcta ttgcccaggc tggaccacag tggcatgatc 70020 ttggctcatt gcagcctgga cctcttggtc tcaagttatc ctaccacctc agcctcctga 70080 tgagctggta gctgggacta caggcatgcg ccaccttgct tggctaaatt ttttttattt 70140 ttagttgaaa ttgggtttaa ctgttttacc caggctggtc ttgaactcct ggactcaagt 70200 gatctgcctg cctcagcctc ccaaagtgct ggaattacaa acatgactca ccgcacccca 70260 ccccttttac tttaatagag acttgcaaga tgctctagcc ttatgtcagc acgtttataa 70320 accatctctt aggatacatt gcaaatgagt gattttgcat gggcttttat ctgtagcctt 70380 agtgggcaat attttcttat ttgaaatgta gagcaacacg atatttgaat ttttttaatg 70440 aacaagacat attccctcta ttaaggaact ctcaatccag tagcagagag aagataccca 70500 aacaactata gtgttatgtg aaagtgatat aagatacaga tataatgaaa gtggggacag 70560 aagaacattt ttggcttcaa ggactaaaga agccttcaga gacaaaaatg tcagttaaac 70620 tgcatcttac aggagaaaca agactttgat aaatcatgat aagagaaagc attctagata 70680 gaaggaacag tatggctgaa ataagaaaag catgagatag gtttgctgaa taatgcatta 70740 aaccagcata ttaatggttc tcaacctttt caagtgtggg gggtccctta gtaacatcaa 70800 aaattttata gtctccccat agggtagtaa ttaaagcttt tagtagctat ggattgagaa 70860 aacacatttg tacatacagt ccctcggaca ctgctacagt aagtactggc cttcgggaga 70920 tttaatcacc caaatggtaa gaaaccattg aaaagaaatt tattttgaac tgaataatgg 70980 aaagtaaact tagaggtgta agttataggc tgatcaagga gggtcttaaa aattactgta 71040 gatgttagag tttaaattaa aagtactaat tcacaattcg gtgtcacctt taaattgtcc 71100 tcatcctgta catcaatacg ttgcagtgaa attgatgtga cagagggggt atgagggaaa 71160 cacttccgtt gcataaattt tgtcttgata tttcagttaa cttagtgaaa actccattta 71220 ggtcaatgct ttgaattttt aaaccttgca ttttttagga catactttat tctttgtgtc 71280 atttcaccag actacttgca attatcagta tcagaatatt agaacagtat tttgcctcat 71340 ttttctgctt ttgaagcgtg ccaaaacaac ttttgagtca gtgagtcatt gcatcttgac 71400 agaggatttt ttctcttcct tcccgaatca gaagactaaa ttaaattatt gctctccaga 71460 aaaaaatgat gagagagaaa tgagagtagc atactgagag taaaggcctt aataaatgtg 71520 ttgataaaga ctaaaccatg gtttttctca caccctattc cactgaaatt atgattgcca 71580 gtggcaacaa aaatttttac ttgtcaaatt agatgaatat ttccagccct taatgtgttt 71640 cacctacctc tgggactatt ggcaaagtaa ctatttcttg ctaagactct tgcttaggta 71700 tttgtcactt cccttccagg tagatatgtt tctctcccta tgtacatttc ccgactcctg 71760 tgtggatttg ttcttccacc cacactataa atttgtttgt gttctgggtt ctatcttttc 71820 cagtcatttc tcactctaca cagtctgcat aagctcattc atagtcttgt cttcaactac 71880 cactatattt cgatgactcc taaatacata atattagcca gaccctctac aaaactactg 71940 aactttcaac tgcttattac acagctccac ccagatgact tctaagtcag catgaccccc 72000 taaacctaag gccttttcca gtatcttgaa atggcacctc agcaagaatt tttggtatca 72060 tccttggctc agtttctcct tcacccctta cccaataaat tgtcaaattc tatcaactcc 72120 acttattaaa tatatgattc attatacatg ctacttctgt tgctacttcc ctgacttagt 72180 ttggtgctgg tcttttttta cttggattca tgttgcagcc tcctgactga ttctattacc 72240 atcaatttca cgtggtgccc aaatgatcct ctattctacc cccagaatca tttttctaaa 72300 acaattttaa tcaatcatat tttccatttc tttttccaaa tagcatccaa actccatggc 72360 ctcaatatcc aagggctttc tgtgatctgg ctcctgaatt tgcagtgtta atctctcatc 72420 attcctcttc acacgactct aagatctagt tccctaaatg ctgtttgctc aaattctagc 72480 cttcttctct tgcccatatt atttttccta cctggcagcc catctctttt cccacgtctt 72540 cctttgactg acctgtaact atctttcagg attcgcatta cttgtcactt gctctgggaa 72600 gatttctctg agccttccta gactgggtga ggaaaccctg taccctccct tgtctccttt 72660 gtgcttgtca accataacac tatgactctg agttacaatt gtgttctact tttctatctg 72720 tctcacaagc ctatagtgtt aaaggcagaa acagcatctt tctaaccttg atcctaattg 72780 caagtataat gcttcctccc aaatagatgg ttaaagaata tttatagaaa tttaaattac 72840 agaattgatt tgcaaagaac tgtactacct tagattatta gacattaact tcttattcag 72900 cataaatcat caaacatacg ttggtgatta tacttaatca tattgaagct tctttgtgct 72960 tctcaacatt gatacttgtg tatgaaagtt gttgctttgt gtcagaaggt gctgagatat 73020 ttaatgctct gccattgttg tagattatct gtttcaatta catgacattt tttacagaac 73080 caaaacctac atattttatc aaaactctgg gagtaagatt ggggaactta gtagtactgt 73140 catacaggcc atcttttttt tttttttttt tcttgagata ggctctcact ctgtcaccca 73200 ggctggagtg cagtggcatg attgtagctc acggcagctt agaactcctg ggctcaagcc 73260 atcgtcctgc ttcagcctcc ccagtaactt cagcctcccc agcactacag gtgtgcacca 73320 ccacacctgg acaagctttt taaattggtt tgtagagact gggtcttggc tggtctcaaa 73380 ttcctggcct caagtgactc tcctgcctcg cctcccaaag cactgggact acgggcatga 73440 gccaccacac ccagccccag gccatctctt cactatatac tttctgttaa ttctttaagc 73500 taaatttgga cagctgtaac agggcttttg tcagaaatta tcaggtcaag tcacttaaaa 73560 ggaaaagtgt tttttttttt aacatttgtt aaacacaatt agtgataatc catcacttct 73620 ccatgtgaag gtttttcatt ttggtcatct caaatgtact aagtttacct gatcattatc 73680 atcactggga atttaatctc tgtgttccca tctttgtttc agcataaagt aatgaatgat 73740 attacagtta ataaggaaaa aaatagcatt tctatactag gcatgttcaa gtcaatttaa 73800 cattgtacat ttatcacaga taagcactgt aaaaggtgga gtaaataaag gttattttct 73860 gagttctatt ccattctgtc aaacaaacag aaatatagtt tctgctataa atattggtaa 73920 ttttataaat ttaaagttat tgtaataaga tttgccttta atgttgtcat aaaataaaag 73980 taagcctgga tttctagtcc cagaatgcaa aaacaaagaa aaaagcaaaa agacgaaaac 74040 aaaaactaag agtaggataa agtgaatgta aacatgtaaa tgtagacagg atctgttttt 74100 ggataaagaa caatttaatt cttacataat tttgtaaaat gtttaaatgt ttaaaactac 74160 tcaaaggtta acataaaaca aatgcctgaa gtgaaaaatt acagcatagt taagtcaaat 74220 atttaaatat tataaaatac tttttttaga aagttataaa gttcaccaag aaagatatag 74280 agaataataa atgtatttgt ggagattatt gtgaacactt ggttaatgtt ttaatacatc 74340 tgattaatga aaacgaactt tctatgagcc tttttttttt tttttttttt tttttttttg 74400 agatggagtc tcgctgtgtc accaggctgg agtgcagtgg cacgttcttg gctcactgca 74460 acctcagcct cctgggttca aaccattctc ctgcctcatc ctcccaagta gctgatgaga 74520 ctacaggcat acaccaccac acctagctaa tttttgtatt tttagtagag acagggtttt 74580 accatgctgg ccaagatggt ctcaatctct tgaccttgtg atccacccac ctcggcctcc 74640 caaagtgctg ggattacagg cgtgagccac tgcgcccagc ccattttttt gtattatatg 74700 aaatatataa tttgttatat ataacaacac acataaaata tatattctgg aaaatatata 74760 ttccagaaca aacacataat ttatctttaa aattttttca ccattatttt ttatacttca 74820 gttctatctt atatgttcta taatatataa aatgcctcct aacacttttt tttatggcat 74880 tgtgttttag tattagagac ttcccattaa actgactggt ggatttcata ctagtattac 74940 tccaatgagc aattctgttg cattgataga ccaataataa atatctccat agtgttctac 75000 agtgtgcata attatcccat ttgtctcata gcaactcact gagttagtta tcattgtgaa 75060 ttgtgatttt tacttatgaa gaaatttaga ttcaatgata ataagtgatg tttccaaagt 75120 ggctgttagt aagtggtaga gccaggactg gaacttgggt cttctgtcct gaatgccttc 75180 caatttgttg agacagatca gcaataggga ggtttatatg tgcctccctt tagaaaggct 75240 tccttttcaa aaattaagac aattcattga tctcttgtca aatgattcta aattttatca 75300 caaaattacc catttttata gtctcttaaa tatttgactt acaagcagca tttatgtatt 75360 agatttattg tattgagctt tataattttc ttaaaaagtt attatgtaga cctatacttg 75420 aagacacgtt caagtcatat gcaaattaaa aaatgataaa acttgcatac caaaaatttt 75480 tttggctgct tagttagaga gtctttctgc acctgagtaa accaggattc ttggatgcca 75540 gtattaaaaa taaactatgt taattataaa acacacaagc aacaacaaaa aaccctgact 75600 tttaaaaaca aaagaaaaag aaaaaaaata atttactgag aggacaacag gggttcactg 75660 aatagaagct agaggacaag cttagaatat gggcagaagc caaggcacat ctgaagggct 75720 aaaaagcaag catcacaaat cctcccattg gttctcatta tctggacacc accaacatca 75780 agaataaata gtcatatctt tctctttgct ttagtatttt ctgattcaaa ttcctgttag 75840 tatatgttcc atgggccaaa cctatgcccc aagcccaaag aaggaggagg tttacccagc 75900 tttctccgtg ggaaagtagg aaggtaaggc atttgctctc gcaaaaacta caaccaatgg 75960 ggaactctgc ccacacagag aaaggaagga ggggaggaag gaaggaggga aggaaagaag 76020 gaaagcagga aggtattagg gagcagtgag ggaggaggag gaaaaagagg aaaggaagaa 76080 agagagggaa ggaagaaagg agggagggag gaagggagtg agagaagaaa ggagggagaa 76140 ggggaagaaa gaaaggaggg aaaaggggag ggaagaaagg aggaagaagg ggagggaaga 76200 aaggagggag aaggggaggg aagaaaggga gaaggggagg gaagaaaggg agaaggggag 76260 ggaagaaagg gagaagggga gggaagaaag gagggagaag gggagggagg aaaggtggga 76320 aggagaaaag gttagacatt gaagagcatc ccttctcagt aaaaggtaaa tgctcactat 76380 ggcatctcta attatgaata tgcatttgag tttttggtct tattgaggct aaggagttct 76440 aagaagagag tagcaatttt tctactattc acatgaagat gggacgatct gaagtgtatg 76500 aagagaagag ccttcttttt tgctacctac cttgacatga ttaacattgt caggaaataa 76560 ctttcttttg ctcttgatag ctaatgaatt aagttttgct ttggttttac ttttgaaaca 76620 gattatttgt aagaacatca gtggattttt agagaaaata gatgttttta aaacagcttt 76680 atagaaagtg gttgatgttc tcagcaaaac attgtctcca tacctttaat tttaaaaatt 76740 ctccattttc atcatttcag ttatactcag atacaaataa ctttcaaatt tatattaata 76800 tttttagccc atatatctcc ccatacttct aattcatatg tgcagctgat accaggatgt 76860 tgacccctga atcctatcca aaactatttt ctccctagca agtttcttct cctttatttt 76920 atctcagcaa tgctgttatc atcatctacc cttcaagaca aatactgaaa gatgtatttg 76980 attccttctt cttcccatct accggcaatc agttgacaaa tgtcttttat ttttcccttt 77040 aaatattttt ctgatgcact ctctcctctt aattccaatg tgttgacttg acttacttca 77100 ggcttttatc atctctcacc tgggctttga cagtatctcc caactgtcct ccctaactcc 77160 agacttattc ccttgaatcc acctaccaca tagctaagaa tgatccatct acaatgcaag 77220 gctatgtcac tcccattgct ccttaataga cttgcaagac cttggatgat ctgacccagc 77280 ctacatctct aaacacatct ttgcttctcc cacctttaag ttactcattg ttgaactggt 77340 gatcttccct tgagaattgg gaagacatgg agagacttgt gatgattaag tcaagattca 77400 tttgcccttt ccctgccatc cttctgccac caacaccatg gaacagccta aaagaggatg 77460 aaagaccaaa gcattcacac catacccccc aatacacaca cacacacaca cacacacaca 77520 cacacacaca cacacacaca cacagattct aaatctctta agccacacgg aagtttaaaa 77580 caagactgga ttaagtttca gagaacgaaa gtgacctgat gactgtggaa tctacccgac 77640 atagttaagg gttgttaaaa gaaaattaga tataacacaa ctgaaagcag tggttttaca 77700 aagtaagacc agtttatgtt taaatcccaa agaactgaga tttaacgaac tgattatatt 77760 ccattcaggc attatctctc tttttttcta gaaagttttt cctgacctcc ctcccgattg 77820 actgatacac tcccttttaa ccttctctac cccagcactc atgtgcttgt ttctcctgtt 77880 gagttgtgag ctgcttttga ggctaggatt gactcttact catcttcatt tttatacagt 77940 gcctggcacc caaatggttc ttattaaatg ggtgttgcat gaatgagtga tggatgatgg 78000 attcacttag caaaatccca gaaatgctaa atcacagtga ctaatttcaa gtgacttcca 78060 aagttgctga tattttaggc tgtattattt attaatgttt tctgattttc agtgtaaaat 78120 atgttgggat tgaaaacatt ttattaccct acgcatacct attttcagat ttatatgtat 78180 tttcaacatt tttgagataa ttcagtcatt tttatggtca ctgtattttt aaatttgttt 78240 tgtaggtttt cgaaacttac atattgatga ccagataact ctcattcagt attcttggat 78300 gagcttaatg gtgtttggtc taggatggag atcctacaaa cacgtcagtg ggcagatgct 78360 gtattttgca cctgatctaa tactaaatga gtaagtagta acttttgttg tttttgttat 78420 tttaagtgta catgtaggat aattttgaaa gttatatttc aatagatgat cacatattta 78480 gtgttcttga tatgatgaca ttactgtcat tttacggtaa ttttatattt ggagcttttt 78540 cctcttgttt caaaatatag ttatatcaaa tccaattttc ttacacatca agaatgtatc 78600 aagaaatata tttaaagata aacttaaatg tttcattaat caatttaaaa tttcatagct 78660 tggtactaat gacaataata aatgagaaat atttttgtta ctgacttaca ttcaaaaagt 78720 aaaaacatct ttcttcatac atgacaaatt agactgctaa tttatttaaa aaattgaaag 78780 ataaatattt caatttgctt tatatttaaa taattttaat taattttcta cctacaacct 78840 ttaactgaat aagaatcttt tcatggtaat atttatattg ttctagtggt aaatgctgac 78900 ttagaagtat ataactcaca cttatataag tctttacagt ttttagataa ttttcatgtt 78960 tcattacatt ttatccaaca attccttgag ataagtaagg aatcagcatt cttcattgta 79020 cagtttagaa aactgagtct caggagaatt atataatctg ccaaataatt tgaatgacag 79080 tgagattcct tatctctttt tagccaaaat ctagttttca ttattcttgt tagcttcatt 79140 tgactaatgt ggacattata aaacaacaca aggttgggaa aatgccttaa ttaaattttc 79200 tcagccttca gcacttgtgt ttaactttgt caattaatta atgcttgcca atgtcctctt 79260 ttactctttt ctgtatcatt gtatatttcc ctagaaaagt ttaaaatatg gtaagctttg 79320 tgaactgact tctcctattt aattgcacac aaaattatat aatttttcat agaaaataaa 79380 ttgtaagtaa ataaaacatt tctgagcatt cttcagcttc acattctcaa ctcctacacc 79440 tctgctgtgt tttcttggtt taggtattta aagtgtgata ataaaagtga gaaacaatgt 79500 taatcttggt cactgtgtat ttaatataat tttctagttt taagatttct taacctcaaa 79560 aattcagtat tgtgaaaagt ttagaagatg tttaaaattc caaatattgg gtttgtttat 79620 taaaagtagt agtcattttc aataatatgt aaggtaatta ccaaaaccat attccctgat 79680 aaattaccta aactggctga gacactattt tttttcctgt tgctttttct tttgtgtatt 79740 gtgtgtgatg caagacagcg gatgaaagaa tcatcattct attcattatg ccttaccatg 79800 tggcagatcc cacaggagtt tgtcaagctt caagttagcc aagaagagtt cctctgtatg 79860 aaagtattgt tacttcttaa tacaagtgag tgagttcaag taacttaatg caagatatct 79920 agtttcttaa ttcattagaa aagttgcaaa caatatgatt atatagttat gtatgaggta 79980 gacgtcttgg attataagta taaagaagaa atacccaata tattgttata gacattaata 80040 aaattactgg attttttcat cttttaccta ccatataata ctaaaatagc ctcatcaatt 80100 tctttttatt ttagataaaa tgatttaatt actctttcat attcacctaa ttcagtaata 80160 taaactacag tcatgtgcca cataataata ttttggtcaa caacagacca catatacaat 80220 ggttccctaa gatgatagtg gagctgaaaa attatcatcg cctagtcctg ttatagccac 80280 cataacatca tagcacaatg cactaatcac atgttcgtgg tgatactaat gtaaacaaac 80340 ctactgtgct gccagtcata taaagtatag cacatacaat tatgtacagt acatagtact 80400 tggtaaagat aataaaaaac tcttactggt ttatgtattt actgtagtat acttttctat 80460 tgagagtcac tacttctact ttttttaagt taaccgcaaa acagcctcag gcaggtctgt 80520 cagagggatt ccagaaaagg gcatacgtca ccctgggaga tgacaactcc gtgtgtgtta 80580 ctgccccctg aagaccttcc agtgagataa gatgttgggg tggatgacag tgatattgat 80640 gattctgact ctgtgtaggt ctaggctaat gtgtgttttg ggtattagtt tttttaaaaa 80700 aagtttaagc aaaaaagaaa atatttaaaa atagataaag tttatagaat aaagatatag 80760 agaaagaaag ccaggcacgg tggcatgtgc ctgtagtccc cactacttgg gaggctgagg 80820 tgagaggatc acttgagccc aggagtttta agtccagcct aagcaacatg tgagaacttg 80880 tctctaaaaa aagaaagaaa gagaactgta ccttgtgttt ttgtttttaa ctaaatgtta 80940 ttacaaaaga gtcaaaaagt taaaaaacta gagtttataa agtaaaaaag ttacggtaag 81000 gtaaagctaa tttattataa aagaaataaa aatattttta taaatgtagt gtagcctaag 81060 tgtacagtgt ttataaaggc tatcgtagtg tatagtaatg tcctaggcct tcacattctg 81120 tcaccactca ctcgctgact cacgcagagc aacttccagt cctgcaagtt ccattcatgt 81180 taagtcccct atgcaagtgt cccattcgta tcttttatat tggattttta ctatgcctct 81240 tctgtgttta gatacaaaac acttaccatt gtgttacagc tgcctacagt attcagtaat 81300 cacatgctgt acaggttcat agcctaggaa taaggcctag gtgtatagta gtctatacca 81360 tctaggtttg tgtgagtaca ctctgtgata atcacacagt gatgaaatca cataaggaca 81420 catttctcag aatatatccc catcattaag tgatacacga ctgcaattaa tattggataa 81480 gcacaaacca tactctcctc taccaccact ctcaccccat ccccaaagta tttactatat 81540 aaaatacata attttgttta gaattatttt tatcaagata aattgttaaa acatgtaact 81600 ataaagatta gcatcttaat ataatagtgg tttctttatc actgacacag tccagtgagt 81660 tagcaagaaa cacccaggct ccttctagcc agtggcttca ccccttccta gtggcttgca 81720 aacctctatt ggacatgact agaaatgagc actgagtgag agagattttg aaggctagat 81780 ctgaaactat catacatcac tttcacccac attccaaggc acttaagctg caggaaaagc 81840 tgggaaatac agtctagcta taggcccaga agaaagagga aattatgttt tataaagcat 81900 tgcattgatc accagaagga caggcaaata tccgttccac tttttcttat atccaaggaa 81960 catacttacc tctgcctcag tggatcccca agggtctggg tgggcaaagt tttaaaaaaa 82020 agaaaaagca gctgctttga cccttgcata ggcaggatca gccctcaaat gtacaaactg 82080 atgcttttgt gattcattgt gatttctatg acaaccacag ggagctaaga cctcaggccg 82140 agggtgagcc taaggtcttt cttggcaaca tctttacagg gacttctttc taaggtccca 82200 aatctcaaat ggctaggggg tgcagatcag gagggaaggg caggagagat aaaccctgaa 82260 atggaaggct tcctcataga atttatgcaa agacagggat gaatacataa ccatcttggg 82320 aaccctattt ggacaaggaa tttcaaggct aatttggtga cagagcatca attgaacaaa 82380 ggatatttac gtggaaccgg cccagagagt caactggaat acatttaata atacagtaat 82440 tagctcctgc ccttctttgc atgaaggaat gaatcctata gcacttatgt cacagatagt 82500 cctagatctt ccaaactggc ttatatcctt aacataattc tctatttatg gataggcaac 82560 attatgctgg ggaattaaac aacaatggaa ttaatcaaca gggaggcttt gctcattgtt 82620 gtcacttaga aacttaggcg atcactagag cagtggtaag aaaaggaagt gagattcata 82680 caacttccac tcacatacca tagagagtaa gatttttagc catttgccac ttcacaaaaa 82740 ggaagaaaaa gaaactattt aatgaatagt acttacgctt tccacaaatt ctaatcaaga 82800 ttctaatgag atttggggag aagagggtga acttgacaaa cctactgaaa atccatcttt 82860 aaaactagaa gaataaatag ataagcatta taaaaatatg cagggaatta gaaagctgct 82920 gttaattaat acagcatggg agaagagata tactgaactt ttgggcaaat cagacaagta 82980 tatattagaa tataaatagt atagtggaaa ccacaaatca atgagtctga aacaaataaa 83040 tgttaagaaa aatagtttta tatttggaaa aaaactgttt ggatatgtag ctcaaattat 83100 atccttgaat aacagataat tgagttaaat gtaaacactc aaataattaa aaaacaagct 83160 agaagaaata gaaataatct tcaatctcaa atacctttta taaaataaat gcaaggagaa 83220 gattggcaaa gtaaaacttt gataatttgg tagttatgaa cttaaacctc tcatttgcca 83280 ttaaatatga aaatataaat ctccaggaat agacagtagg ttgaacaaac atttttacat 83340 tgttctctcc aaaattacac taaaggccag atgtagtcgg tcacatttct aatcacactt 83400 tgggagggca agctgggcag atggcttgaa cccaggagtt tgagaccagc ctaggcaact 83460 tggaaaaccc cgtctctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 83520 attagccagg cgtagtggca agtgcctgta gtcccaggta gccgggaaac tgaggtggga 83580 ggatcacctc aacctaggaa gtcgaggctg cagtgagcca tgattgtgcc actgtactcc 83640 tgcctgggtg attgagtgag accatgtctc aaaataaaaa taaataaata aataaataaa 83700 aataaataaa ttacactaaa atcttagtaa agggatttac tatgaaaaat taagaaaaaa 83760 tgattttaca ttcatgttta cagctgaggg aaatataggg attggttggt aaccttaaag 83820 agagctgtga aagtttgaaa tgactgctat ttgaagtagt ccagaaaatt agtacagcct 83880 ctatggaaca ccatatggag atttctcaaa aaactataaa tataactacc attctatcta 83940 gcaatcccac cactggatat ctacccaaag gaaaagaaat cattatgtca aaaagacacc 84000 tgcactcttg tttattacag cagtattcac tatagcaaag ataggaaatc aatccaagtg 84060 tgtatcaaca gataatagga taaagaaaat gtgatgtact cacacatata catacataca 84120 cacacacaca cacacacaca cacacacaaa atggaatagt attcagcaat caaaaagaat 84180 gaaagtgtgt cttttgcagc aacatggatg gaacaggaag tcattatctt aagtgaaaca 84240 attcagagac aaagtcagat accacatgtt ctcgcttata agtgggagct aaataatgca 84300 tgtacatggg catagagtat agaataattg acagtggtgc cttagaaggc tggaaaggta 84360 ggaggggggt gagacattac ctaatggata caatgtgcat tattgggtga tggttatacc 84420 aaaagctcag atttcaccac tatgcaatat attcatgtaa caaaactgca cagatggtca 84480 ttaaatttat acaaatttaa taaaaagagg ttctagatat acatatagat gtacatacta 84540 gagttaagtt ttcaattgac aaaaatttgc atagatatac tgaattgcca gaattactct 84600 tcagagtctc ctttatatac aagatcttga aaactcaaaa ccaaagaatt aacttatttg 84660 tttttcataa gtttgtatct ctggccttct tttctagggg aaatggaaac caagttttga 84720 ttggggtgca ggggataaat acaggcttaa gaaatagtaa ttttcctccc tgttccctga 84780 gatacaacaa tattggaatt aggccaaggc tgggcatggt ggctcaagcc cgtaattcca 84840 gcactttggg aagctgaggt gggcgaatca cttgaggtga ggagttcaag accagcctgg 84900 ccaatatagt gaaaccccat ctctaccaaa aagacaaaaa ttagtcggac atgatggcac 84960 acacttgtaa tcctagctac tcaggaggct gaggcgggag aattgcttga acatgggagg 85020 cggaggttgc agtgacctga gattgtgcca ctgaactcca gcctgggcga cagagcaaga 85080 ccctgtgtca aaaaaaaaaa aaaaaaaaaa aaagcaatta ggccaactaa caatcttgga 85140 atggcctctc agtgttccag taaaagaaag agttgcaagt ctgaggtaga aatgattaag 85200 cttaattagg aaggcatgtc aaaagttgat ataggttgaa aactaggtct cctgagccaa 85260 gcaactagcc aagtttcaaa tacaaagtaa gagttcttga aggactttaa aagtgccatt 85320 ccagtgaaca catgaatgat aagcaaaacc gccttattgc tgatatggag aaagttttag 85380 tggtctgaat agaagatcaa accagccaca atattccctt aagcctaagc ctcatccaga 85440 ggaaggccct gattctcctc aatactagga aggcaaagag atgtaaggaa ggagcagaaa 85500 aaagtttgaa gctagcagaa gttggttcat gagatttaag aagccatttc cataacaaag 85560 tataaggtga agcagcaagt gctgatgcag aagctgcagc aagttaccca gaagatctag 85620 gtaagattat cgctacttat gaaagtagct gtgctaaaaa acaggttttc agggtagata 85680 aaacagcttt ccactggaag aagatgtcat ctaggacttt catagctaca gagaacaagt 85740 caatgtctgt cttcaaagct tcaaatgaca ggttgactct cttgttaggg gctaatgaag 85800 ctggtgactt gaagctgaag ctggtgactt gaagctgaag ctaatgctca tttatcattc 85860 tgaagatcct aaggccttta agaattacgc tcaatctgtt ctgcctgtgg tttatgaatg 85920 gaacaacaaa gctggatgac agcacatcta tttatggcat ggtttactga atattttgac 85980 ccactattga gacttactgc tcagaaaaga atactacttt caaatattat tgctcattga 86040 caatgcacct agtcagccaa gagctcttat ggatatatac aaggagatta atgttttcat 86100 ttctgctaac acaacattca ttctgtagtt catagatcaa agagtaattt tccactttca 86160 tgtcttatta tttaagaaat atattttgta aagctgtggc tgccatagat agtgtttcct 86220 ctgatggatc tgggtaaagt aaattgaaaa ccttctagaa aggattcacc tttctagatg 86280 ccattaagaa cattcgtgat tcatgggaga aggtgaaaat agcaacatta acaagagttt 86340 ggaagaagtt tatttcatcc ctcttgcatg actttgaggg tgttcaaaac ttcagtggag 86400 gaaataacta cagatatgtg aaaagagcaa gagaactaaa attagaagta aagcctgaag 86460 acatgactga attgaagagg tttcgtggta aaacttgaaa gatgaggagt tgtttcttat 86520 ggatgagcaa agaaagtggt ttcttgagtt ggaatctact tctagtgaag atgctatgaa 86580 gattattgaa gtgacaacaa aggatttcgg agattacata aacttagttg ataatgcagc 86640 agcaggactt aagaggattg actccaatta tgaaagaagt tctattgtgg gtaaattgcc 86700 atcaaactgc tagcattgca tgctacagaa aaattattca caaaagagtc aactgatgca 86760 gcaaacttca ttgttgcctt attttgagaa actgtcatag ccaccccaac cttcagcaac 86820 caccaccctg gccaatcagc agccatcaac atttagacaa caccctccaa cagcaaaaag 86880 attttgactc agggaagact cagatgattg ttaccatttt ctagcaataa agtgtttttt 86940 agttaaggtg tgttcacttt ttaaataatg ctgttgcaca cttaatacat tctagtatag 87000 tgtaaatata acttctacgt ggactgggaa acaaaaagat gcatgtgatt cactttgttg 87060 caatatttcc ttcattgccg tggtctggaa ccaaaccggc tatatctcca agatatgcct 87120 gtgtaacaaa gtggctggat ataagataaa tatttaaata ttaatacctt tctcccatat 87180 cagcaggaag gcattagaaa acttaatgaa gcaattttta aaattacaac aaaaagataa 87240 atcatctagg aataatctta atggcaaata cttgagattt atataaagaa gacaaaagtt 87300 tactaagaga tccaagtatt cattaaaaag aagggaaaaa aaagatccag attacatgca 87360 gctgtaaact aagtcaaacc aagtatttaa gaagcatgta gaataaggcc aggttctctt 87420 ttgagcaaat gctaagttaa atgcacaatc cattgataca ggtctaaaat aggtcagctg 87480 aagtgttctt taatatacct attaattctt atgttcttcc agtgaactag aagtttatat 87540 gtcctgatat tgatagtgat atcaataaca ctatctcttt cctatataag gtgttttttt 87600 tctagagtca tgtatcagaa gaaatcatta tatagctcag aaatatatgt tataaattgt 87660 taatgtcatc tttttataca caactgccac ttttaattgt cttcttaaca gttcctttgg 87720 aagggctacg aagtcaaacc cagtttgagg agatgaggtc aagctacatt agagagctca 87780 tcaaggcaat tggtttgagg caaaaaggag ttgtgtcgag ctcacagcgt ttctatcaac 87840 ttacaaaact tcttgataac ttgcatgatg taagtatttg gttgattcca gaatatcaat 87900 gattattctc tgaatttcta taacttttta aatgttacat gtaaatttta ctttgtatga 87960 ttttctcaga ttaatacttg tatgttaaaa gtgtttggat catgctgctc agacttttta 88020 ttgtgttttt ttttcatttt caatatagac cactcaaata ttcttttaca agtatttgta 88080 taatgtgagg gtaatttaat agctgataga aattatggta catttcctga atatgttcta 88140 aaatatttgt gcctaaaatt ataaaagatt ttatatatac agtaaaaaca aaggtatgta 88200 tgtgaaaaat aagactcatg ccattttcag tggaattata aataacattg ctgatgggtg 88260 ggcaatcagg caatacatag caaaagttaa aatttgcatg cttttcaagt ttctattttt 88320 taggatttat cttaaagaaa taattagaca aatgtaatat acatgcaagg atgttcacca 88380 tagcagaggg ggaaaaaaga aaagcaaaca agaaatgccc aacaccagag gtggattact 88440 aagacaagat atctgtggtt tgtcaagata tatgaaatac aagcttttat tgctactatg 88500 ttcagatcac attaaaatga cagtgaaggc ataaaaaagc tatccactct ccaggtcaac 88560 ttttgaggtc ttactcctga atacgaacag acagccaaga ttatgagcta tttgagtaaa 88620 gcctctaaaa tgaaaggcag aaagcaaaat aaaaagaaac ttgaaggaaa taaacaccag 88680 tgcagagaac agaagaaaac ttctaacatc ctcagagaaa taagaatgat acggtatcca 88740 tgacatgaga acagaaaaca tttttaaaac agacatttag caagaaaata cttttggata 88800 attaaatgaa gaaaggcaga aattgaaaat tcaatgaaag ggctgaaatg gaaaggaaaa 88860 tctgaggaaa aataaaagat caaaacatgg aaaattagaa agaagagtta tagtaaattt 88920 agtattcagg agattctagc ctccaattaa taggaatgtc cagaagaaaa aatagagaaa 88980 atcaaggaga gaaatttgtg taagaaatcg caaaagttgc tggaactgaa acatacaagt 89040 tttctaacaa aaagggtccg gtgtagaggc actgcacaat tgaactaagg tacattattg 89100 taaaattgta ccaggccaga aatgaagaga atattttaaa gtataccagt gatgaaagaa 89160 acaggtcaca tagacgttat caggattcag aatgatgttg gacttctctg cagcaacact 89220 ggaagccaga agacagtgga gcagtgcctt cagaatttga tggaaaagaa aatcttcaaa 89280 gaatttcata cctagccaaa ccatcaaaca agtacaatgg cagcatgaaa gtattttcca 89340 acttgcaagg tctcctagag tttacctcag atacaacttt ctcaagaact gctacaggat 89400 gtcttataac aaaacatggg attaagccaa agatccaccc caacagagat gcaaagtgat 89460 gtcccagaac aataactgtg cagagcagta gttagtctag atgggagcag taatacaaag 89520 ggttctagga taccagctcc aggaaaaata aatggaactg agagattacc actaagtatg 89580 actgtaattg aggtgatttt tacaattctg ttgcagaatt tgactatggc tttgagacaa 89640 atatagagaa aacaaagcaa acaagaacac gaggtgattc acttttgcaa aataaaaata 89700 agtcgtaaga atggagatgc aatccagcag aaaaccataa aaaaatcttt atgatataaa 89760 tgctggatat tgactttagc taaaaattga gccaaaagct ctctctgggg agaagagaac 89820 atgtatgtag ttgaggaaga gagtgtctag tataagagag cttcattttc ttcatttcct 89880 atagtagaaa ctaaaactaa ctttagtgga aatatagaaa tatcaaaaga cacaggctac 89940 aaaaagttga aggtagttgt gtctagggag ctggaatagg gatgggaaga agtctatcag 90000 gaaactgcta ggctctattg atgctgctgc tgctgctgtt tttgttttta taatcatgtg 90060 gtactacttg actttcaaca ttatacacat gaattacttt gataaaaatt aaacgatgtt 90120 ggattattgg cataggaaga accaatatgt tgttatataa aacagctaga ttagcaaata 90180 gaatttatga aacatgtgta atattgtgtg tatgcttggg tatgtctgta tacatgtata 90240 aaaagaaaaa aaaacttgag taatacacca aaatgttcac acagcttatc ctgtagaatt 90300 gtgaataact ttcatttctt taaataaatc tttccataat atcagaatgt tctatcatga 90360 gtatataaca ttttacatat tattctagaa aatggtggga gttattttca ctatggtaag 90420 aaaaaaacac cttgagaagt atttatatta taaatagtta gaaaaataaa ttgccatgtt 90480 tgaatagcat atgaatttat tatttttatt acatgttttc tactcatttg ttaaaccaac 90540 agcttgtcaa acaacttcat ctgtactgct tgaatacatt tatccagtcc cgggcactga 90600 gtgttgaatt tccagaaatg atgtctgaag ttattgctgc acaattaccc aagatattgg 90660 cagggatggt gaaacccctt ctctttcata aaaagtgaat gtcatctttt tcttttaaag 90720 aattaaattt tgtggtatgt ctttttgttt tggtcaggat tatgaggtct tgagttttta 90780 taatgttctt ctgaaagcct tacatttata acatcatagt gtgtaaattt aaaagaaaaa 90840 ttgtgaggtt ctaattattt tcttttataa agtataatta gaatgtttaa ctgttttgtt 90900 tacccatatt ttcttgaaga atttacaaga ttgaaaaagt actaaaattg ttaaagtaaa 90960 ctatcttatc catattattt cataccatgt aggtgaggat ttttaacttt tgcatctaac 91020 aaatcatcga cttaagagaa aaaatcttac atgtaataac acaaagctat tatatgttat 91080 ttctaggtaa ctccctttgt gtcaattata tttccaaaaa tgaaccttta aaatggtatg 91140 caaaattttg tctatatata tttgtgtgag gaggaaattc ataactttcc tcagattttc 91200 aaaagtattt ttaatgcaaa aaatgtagaa agagtttaaa accactaaaa tagattgatg 91260 ttcttcaaac taggcaaaac aactcatatg ttaagaccat tttccagatt ggaaacacaa 91320 atctcttagg aagttaataa gtagattcat atcattatgc aaatagtatt gtgggttttg 91380 taggttttta aaataacctt ttttggggag agaattgtcc tctaatgagg tattgcgagt 91440 ggacataaga aatcagaaga ttatggccta actgtactcc ttaccaactg tggcatgctg 91500 aaagttagtc actcttactg attctcaatt ctctcacctt tgaaagtagt aaaatatctt 91560 tcctgccaat tgctcctttg ggtcagagct tattaacatc ttttcaaatc aaaggaaaga 91620 agaaagggag aggaggagga gggaggtatc aattcacata cctttctcct ctttatcctc 91680 cactatcatg aattcatatt atgtttcagc catgcaaatc tttttaccat gaaatttctt 91740 ccagaatttt ccccctttga cacaaattcc atgcatgttt caaccttcga gactcagcca 91800 aatgtcattt ctgtaaaatc ttccctgagt cttccaagca gtaatttgcc ttctcctaga 91860 gtttacctgc cattttgtgc acatttgagt tacagtagca tgttatttta caattgtgac 91920 tctcctggga gtctgggagc catataaagt ggtcaatagt gtttgctgac tgagagttga 91980 atgacatttt ctctctgtct tggtattact gtagatttcg atcattcttt ggttacattt 92040 ctgcatattt ctgtacccat gactttatca ctttcttctc ccatgcttta tctccatcaa 92100 ttatcttcat tacttttaaa ttttccacct ttgcttccta ctttgtgaga tctctccctt 92160 tactgactat aacatagaag aatagaagtg tattttatgt gtcttaagga caatacttta 92220 gattccttgt tctaagtttt taaactgaat gaatggaata ttatttctct ccctaagcaa 92280 aattccacaa aacaattatt tcttatgttt atgtagcctt aaattgtttt gtactgtaaa 92340 cctcagcata aaaactttct tcatttctaa tttcattcaa caaatattga ttgaatacct 92400 ggtattagca caagaaaaat gtgctaataa gccttatgag aatttggagc tgaagaaaga 92460 catataactc aggaaagtta cagtccagta gtaggtataa attacagtgc ctgataaata 92520 ggcattttaa tatttgtaca ctcaacgtat actaggtagg tgcaaaacat ttacatataa 92580 ttttactgat acccatgcag cacaaaggta ctaactttaa atattaaata acacctttat 92640 gtgtcagtaa ttcatttgca ttaaatctta ttgaaaaggc tttcaatata ttttccccac 92700 aaatgtcatc ccaagaaaaa agtattttta acatctccca aatataatag ttacaggaaa 92760 tctacctctg tgagagtgac acctctcaga atgaactgtg tgacacaaga aaatgaatgt 92820 aggtctatcc aaaaaaaacc ccaagaaaca aaaacaatat tattagccct ttatgcttaa 92880 gtgatggact cagggaacag ttgatgttgt gatcatttta ttatctgatt cttgttactt 92940 tgaattaaac caatattttg atgatataaa tcatttccac cagcatatat ttaatttcca 93000 taataacttt aaaattttct aatttcactc aactatgagg gaatagaatg tggtggccac 93060 aggtttggct tttgttaaaa tgtttgatat cttcgatgtt gatctctgtc tgcaatgtag 93120 atgtctaaac actaggattt aatatttaag gctaagcttt aaaaataaag taccttttta 93180 aaaagaatat ggcttcacca aatggaaaat acctaatttc taaatctttt tctctacaaa 93240 gtcctatcta ctaatgtctc cattactatt tagtcatcat aaccattatc ttcattttac 93300 atgtcgtgtt ctttctggta gctctaaaat gacactaaat cataagaaga caggttacat 93360 atcaggaaat acttgaaggt tactgaaata gattcttgag ttaatgaaaa tattttctgt 93420 aaaaaggttt gaaaagccat ttgagtctaa agcattatac ctccattatc agtagttatg 93480 tgacaattgt gtgtgtgttt aatgtttaaa gatgtggcac tttttaataa ggcaatgcta 93540 tgctattttt tcccatttaa cattaagata atttattgct atacagatga tatggaaata 93600 tgatgaacaa tatttttttt gccaaaacta tgccttgtaa gtagccatgg aatgtcaacc 93660 tgtaacttaa attatccaca gatagtcatg tgtttgatga tgggcactgt ggagataact 93720 gacataggac tgtgcccccc ttctctgcca cttactagct ggatgagatt aagcaagtca 93780 tttaactgct ctgattaaac ctgcctttcc caagtgcttt gtaatgaata gaaatggaaa 93840 ccaaaaaaaa cgtatacagg ccttcagaaa tagtaattgc tactattttg ttttcattaa 93900 gccatagttc tggctataat tttatcaaac tcaccagcta tattctacag tgaaagcagg 93960 attctagaaa gtctcactgt tttatttatg tcaccatgtg ctatgatata tttggttgaa 94020 ttcatttgaa attagggctg gaagtattca agtaatttct tctgctgaaa aaatacagtg 94080 ttttgagttt agggcctgtt ttatcaaagt tctaaagagc ctatcactct tccattgtag 94140 acattttaaa ataatgacac tgattttaac atttttaagt gtctttttag aacagagagc 94200 ctgactagaa cacagcccct ccaaaaaccc atgctcaaat tatttttact atggcagcaa 94260 ttccacaaaa gggaacaatg ggtttagaaa ttacaatgaa gtcatcaacc caaaaaacat 94320 ccctatccct aagaaggtta tgatataaaa tgcccacaag aaatctatgt ctgctttaat 94380 ctgtctttta ttgctttgga aggatggcta ttacattttt agtttttgct gtgaatacct 94440 gagcagtttc tctcatccat acttatcctt cacacatcag aagtcaggat agaatatgaa 94500 tcattttaaa aacttttaca actccagagc catgtgcata agaagcattc aaaacttgcc 94560 aaaacataca ttttttttca aatttaaaga tactctattt ttgtattcaa tagctcaaca 94620 actgtggtcc ccactgataa agtgaagtgg acaaggagac aagtaatggc ataagtttgt 94680 ttttcccaaa gtatgcctgt tcaatagcca ttggatgtgg gaaatttcta catctcttaa 94740 aattttacag aaaatacata gccagatagt ctagcaaaag ttcaccaagt cctaaattgc 94800 ttatccttac ttcactaagt catgaaatca ttttaatgaa aagaacatca cctaggtttt 94860 gtggtttctt tttttcttat tcatggctga gtgaaaacaa caatctctgt ttctccctag 94920 catctgtgga ctatttaatg taccattatt ccacactcta tggtccttac taaatacaaa 94980 attgaacaaa aagcagtaaa acaactgact cttcacccat attataaaat ataatccaag 95040 ccagattagt caacatccat aagatgaatc caagctgaac tgggcctaga ttattgagtt 95100 caggttggat cacatcccta tttattaata aacttaggaa agaaggcctt acagaccatc 95160 agttagctgg agctaataga acctacactt ctaaagttcg gcctagaatc aatgtggcct 95220 taaaagctga aaagaagcag gaaagaacag ttttcttcaa taatttgtcc accctgtcac 95280 tggagaaaat ttaagaattt gggggtgttg gtagtaagtt aaacacagca gctgttcatg 95340 gcagaaatta ttcaatacat accttctctg aatatcctat aaccaaagca aagaaaaaca 95400 ccaaggggtt tgttctcctc cttggagttg acctcattcc aaggcagagc tcaggtcaca 95460 ggcacagggg ctgcgcccaa gcttgtccgc agccttatgc agctgtggag tctggaagac 95520 tgttgcagga ctgctggcct agtcccagaa tgtcagcctc attttcgatt tactggctct 95580 tgttgctgta tgtcatgctg accttattgt taaacacagg tttgtttgct ttttttccac 95640 tcatggagac atgggagagg cattattttt aagctggttg aaagctttaa ccgataaagc 95700 atttttagag aaatgtgaat caggcagcta agaaagcata ctctgtccat tacggtaaag 95760 aaaatgcaca gattattaac tctgcagtgt ggcattagtg tcctggtcaa tattcggata 95820 gatatgaata aaatatttaa atggtattgt aaatagtttt caggacatat gctatagctt 95880 atttttatta tcttttgaaa ttgctcttaa tacatcaaat cctgatgtat tcaatttatc 95940 agatataaat tattctaaat gaagcccagt taaatgtttt tgtcttgtca gttatatgtt 96000 aagtttctga tctctttgtc tatgacgttt actaatctgc atttttactg ttatgaatta 96060 ttttagacag cagtggtttc aagctttttg ccactaaaaa taccttttat tttctcctcc 96120 cccagaaaag tctatacctt gaagtatcta tccaccaaac tgtacttcta ttaagaaata 96180 gttattgtgt tttcttaatg ttttgttatt caaagacata tcaatgaaag ctgctgagca 96240 gcatgaataa caattatatc cacacagatt tgatatattt tgtgcagcct taacttgata 96300 gtataaaatg tcattgcttt ttaaataata gttagtcaat ggacttctat catagctttc 96360 ctaaactagg ttaagatcca gagctttggg gtcataatat attacataca attaagttat 96420 ctttttctaa gggctttaaa attcatgaga ataaccaaaa aaggtatgtg gagagttaat 96480 acaaacatac catattcttg ttgaaacaga gatgtggctc tgcttgttct ccataaggta 96540 gaaatacttt ccagaatttg cctaaactag taagccctga atttgctatg attagggata 96600 ggaagagatt ttcacatggc agactttaga attcttcact ttagccagta aagtatctcc 96660 ttttgatctt agtattctgt gtattttaac ttttctgagt tgtgcatgtt tataagaaaa 96720 atcagcacaa agggtttaag ttaaagcctt tttactgaaa tttgaaagaa acagaagaaa 96780 atatcaaagt tctttgtatt ttgagaggat taaatatgat ttacaaaagt tacatggagg 96840 gctctctaaa acattaaatt aattattttt tgttgaaaag tcttacttta ggcatcattt 96900 tattcctcag caactagctg tgaagccttt actgtgctgt atgccagtca ctctgctaga 96960 ttgtggagat taccagtgtt cccgtcttct ccgagcttag agttggatgg ggaataaaga 97020 caggtaaaca gatagctaca atattgtact gtgaatgctt atgctggagg aagtacaggg 97080 aactattgga gcacctaaga ggagcaccta ccttgaattt aggggttagc agaggcatcc 97140 tgaaaaaagt caaagctaag ccacaatcta taagcagttt aggaattagc agaacgtgcg 97200 tggtgaggag atgccaaagg caagaagaga agagtattcc aaacaggagg gattccaaag 97260 agagaagagt atcccaaaca acatttgcac aaacctgatg gggagagaga atgtggggtg 97320 gggatggatg atgagactga agaagaaagc caggtctaga taatcagtgg ccttgtacac 97380 catgttaaag agtgtagact tgattctgtt gtaaacagga aagcagcaca attcatatga 97440 atattttaga agactcccac tggaatatgg agaataaagt tggagatgac taatcctgga 97500 agcagggaga acatttttga ggaagttgca ctattttggt gaaaatgatg atcataaaca 97560 tgaagaattg taggtgatca tgacctcctc tctaattttc cagaagggtt ttggaagata 97620 taacatagga acattgacag gactgacgaa aggagatgaa atacaccata taaattgtca 97680 aacacaaggc cagatgtcta attattttgc ttatgtgttg aaattacaaa tttttcatca 97740 ggaaaccaaa aactacaaaa cttagttttc ccaagtccca gaattctatc tgtccaaaca 97800 atctgtacca ctccacctat atccctacct ttgcatgtct gtccaacctc aaagtccagg 97860 tctatacaca cgggtaagac tagagcagtt caagtttcag aaaatgagaa agaggaactg 97920 agttgtgctg aacccataca aaataaacac attctttgta tagattcttg gaacctcgag 97980 aggaattcac ctaactcata ggtatttgat ggtatgaatc catggctggg ctcggctttt 98040 aaaaagcctt atctgggatt ccttctatgg aaccaagttc catcaaagcc catttaaaag 98100 cctacattaa aaacaaaatt cttgctgcat tgtatacaaa taatgatgtc atgatcaaat 98160 aatcagatgc cattatcaag tggaattaca aaatggtata cccactccaa aaaaaaaaaa 98220 aaagctaaat tctcagtaga acattgtgac ttcatgagcc ctccacagcc ttggagctga 98280 ggagggagca ctggtgagca gtaggttgaa gagaaaactt ggcgcttaat aatctatcca 98340 tgttttttca tctaaaagag ccttcttttt ggattacctt attcaatttc catcaaggaa 98400 attgttagtt ccactaacca gacagcagct gggaaggcag aagcttactg tatgtacatg 98460 gtagctgtgg gaaggaggtt tctttctcca ggtcctcact ggccatacac cagtcccttg 98520 ttagttatgc ctggtcatag acccccgttg ctatcatctc atatttaagt ctttggcttg 98580 tgaatttatc tattctttca gcttcagcac tgcagagtgc tgggactttg ctaacttcca 98640 tttcttgctg gcttagcaca ttcctcatag gcccagctct tttctcatct ggccctgctg 98700 tggagtcacc ttgccccttc aggagagcca tggcttacca ctgcctgcta agcctccact 98760 cagctgccac cacactaaat ccaagcttct ctaagatgtt gcagacttta caggcaagca 98820 taaaaggctt gatcttcctg gacttccctt tacttgtctg aatctcacct ccttcaactt 98880 tcagtctcag aatgtaggca tttgtcctct ttgccctaca tcttccttct tctgaatcat 98940 gaaagcctct cacttcctct tgctatgtgc tggaggcttc tgtcaggttt tagaatgagt 99000 tctcatctag tcctagtagc ttttgatgct taagtccacc ttttaaggat acctttgaga 99060 tttagaccat gtttttcgct tgagaaagcc ctaatctcca gacttgcctt tctgtggatt 99120 tcaaagacca actgaggaag tcaaaagctg aatgttgact ttctttgaac atttccgcta 99180 taacaattcc aattctcctc agagcaatat gcctgcctcc aactgaccag gagaaaggtc 99240 cagtgccaaa gagaaaaaca caaagattaa ttatttcagt tgagcacata ctttcaaagt 99300 ggtttgggta ttcatatgag gttttctgtc aagagggtga gactcttcat ctatccatgt 99360 gtgcctgaca gttctcctgg cactggctgg taacagatgc aaaactgtaa aaattaagtg 99420 atcatgtatt ttaacgatat catcacatac ttattttcta tgtaatgttt taaatttccc 99480 ctaacatact ttgactgttt tgcacatggt agatattcac atttttttgt gttgaagttg 99540 atgcaatctt caaagttatc taccccgttg cttattagta aaactagtgt taatacttgg 99600 caagagatgc agggaatctt tctcatgact cacgccctat ttagttatta atgctactac 99660 cctattttga gtaagtagta ggtccctaag tacattgtcc agagttatac ttttaaagat 99720 atttagcccc atatacttct tgaatctaaa gtcatacacc ttgctcctca tttctgagtg 99780 ggaaagacat ttgagagtat gttgacaatt gttctgaagg tttttgccaa gaaggtgaaa 99840 ctgtcctttc atctgtgtat gcctggggct gggtccctgg cagtgatggg gtgacaatgc 99900 aaagctgtaa aaactaggtg ctagtgggca cctaatatca tcatcatata cttattttca 99960 agctaatatg caaaatccca tctctgtttt taaactaagt gtagatttca gagaaaatat 100020 tttgtggttc acataagaaa acagtctact cagcttgaca agtgttttat gttaaattgg 100080 ctggtggttt gaaatgaatc atcttcacat aatgttttct ttaaaaatat tgtgaattta 100140 actctaattc ttgttattct gtgtgataat aaagaataaa ctaatttcta 100190 <210> 39 <211> 933 <212> PRT <213> Homo sapiens <400> 39 Met Thr Glu Leu Lys Ala Lys Gly Pro Arg Ala Pro His Val Ala Gly 1 5 10 15 Gly Pro Pro Ser Pro Glu Val Gly Ser Pro Leu Leu Cys Arg Pro Ala 20 25 30 Ala Gly Pro Phe Pro Gly Ser Gln Thr Ser Asp Thr Leu Pro Glu Val 35 40 45 Ser Ala Ile Pro Ile Ser Leu Asp Gly Leu Leu Phe Pro Arg Pro Cys 50 55 60 Gln Gly Gln Asp Pro Ser Asp Glu Lys Thr Gln Asp Gln Gln Ser Leu 65 70 75 80 Ser Asp Val Glu Gly Ala Tyr Ser Arg Ala Glu Ala Thr Arg Gly Ala 85 90 95 Gly Gly Ser Ser Ser Ser Pro Pro Glu Lys Asp Ser Gly Leu Leu Asp 100 105 110 Ser Val Leu Asp Thr Leu Leu Ala Pro Ser Gly Pro Gly Gln Ser Gln 115 120 125 Pro Ser Pro Pro Ala Cys Glu Val Thr Ser Ser Trp Cys Leu Phe Gly 130 135 140 Pro Glu Leu Pro Glu Asp Pro Pro Ala Ala Pro Ala Thr Gln Arg Val 145 150 155 160 Leu Ser Pro Leu Met Ser Arg Ser Gly Cys Lys Val Gly Asp Ser Ser 165 170 175 Gly Thr Ala Ala Ala His Lys Val Leu Pro Arg Gly Leu Ser Pro Ala 180 185 190 Arg Gln Leu Leu Leu Pro Ala Ser Glu Ser Pro His Trp Ser Gly Ala 195 200 205 Pro Val Lys Pro Ser Pro Gln Ala Ala Ala Val Glu Val Glu Glu Glu 210 215 220 Asp Gly Ser Glu Ser Glu Glu Ser Ala Gly Pro Leu Leu Lys Gly Lys 225 230 235 240 Pro Arg Ala Leu Gly Gly Ala Ala Ala Gly Gly Gly Ala Ala Ala Val 245 250 255 Pro Pro Gly Ala Ala Ala Gly Gly Val Ala Leu Val Pro Lys Glu Asp 260 265 270 Ser Arg Phe Ser Ala Pro Arg Val Ala Leu Val Glu Gln Asp Ala Pro 275 280 285 Met Ala Pro Gly Arg Ser Pro Leu Ala Thr Thr Val Met Asp Phe Ile 290 295 300 His Val Pro Ile Leu Pro Leu Asn His Ala Leu Leu Ala Ala Arg Thr 305 310 315 320 Arg Gln Leu Leu Glu Asp Glu Ser Tyr Asp Gly Gly Ala Gly Ala Ala 325 330 335 Ser Ala Phe Ala Pro Pro Arg Ser Ser Pro Cys Ala Ser Ser Thr Pro 340 345 350 Val Ala Val Gly Asp Phe Pro Asp Cys Ala Tyr Pro Pro Asp Ala Glu 355 360 365 Pro Lys Asp Asp Ala Tyr Pro Leu Tyr Ser Asp Phe Gln Pro Pro Ala 370 375 380 Leu Lys Ile Lys Glu Glu Glu Glu Gly Ala Glu Ala Ser Ala Arg Ser 385 390 395 400 Pro Arg Ser Tyr Leu Val Ala Gly Ala Asn Pro Ala Ala Phe Pro Asp 405 410 415 Phe Pro Leu Gly Pro Pro Pro Pro Leu Pro Pro Arg Ala Thr Pro Ser 420 425 430 Arg Pro Gly Glu Ala Ala Val Thr Ala Ala Pro Ala Ser Ala Ser Val 435 440 445 Ser Ser Ala Ser Ser Ser Gly Ser Thr Leu Glu Cys Ile Leu Tyr Lys 450 455 460 Ala Glu Gly Ala Pro Pro Gln Gln Gly Pro Phe Ala Pro Pro Pro Cys 465 470 475 480 Lys Ala Pro Gly Ala Ser Gly Cys Leu Leu Pro Arg Asp Gly Leu Pro 485 490 495 Ser Thr Ser Ala Ser Ala Ala Ala Ala Gly Ala Ala Pro Ala Leu Tyr 500 505 510 Pro Ala Leu Gly Leu Asn Gly Leu Pro Gln Leu Gly Tyr Gln Ala Ala 515 520 525 Val Leu Lys Glu Gly Leu Pro Gln Val Tyr Pro Pro Tyr Leu Asn Tyr 530 535 540 Leu Arg Pro Asp Ser Glu Ala Ser Gln Ser Pro Gln Tyr Ser Phe Glu 545 550 555 560 Ser Leu Pro Gln Lys Ile Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 565 570 575 Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 580 585 590 Arg Ala Met Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp 595 600 605 Cys Ile Val Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Leu 610 615 620 Arg Lys Cys Cys Gln Ala Gly Met Val Leu Gly Gly Arg Lys Phe Lys 625 630 635 640 Lys Phe Asn Lys Val Arg Val Val Arg Ala Leu Asp Ala Val Ala Leu 645 650 655 Pro Gln Pro Val Gly Val Pro Asn Glu Ser Gln Ala Leu Ser Gln Arg 660 665 670 Phe Thr Phe Ser Pro Gly Gln Asp Ile Gln Leu Ile Pro Pro Leu Ile 675 680 685 Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala Gly His Asp 690 695 700 Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser Leu Asn Gln 705 710 715 720 Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser Lys Ser Leu 725 730 735 Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr Leu Ile Gln 740 745 750 Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp Arg Ser Tyr 755 760 765 Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp Leu Ile Leu 770 775 780 Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu Cys Leu Thr 785 790 795 800 Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val Ser Gln Glu 805 810 815 Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr Ile Pro Leu 820 825 830 Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg Ser Ser Tyr 835 840 845 Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys Gly Val Val 850 855 860 Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Asn Leu 865 870 875 880 His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn Thr Phe Ile 885 890 895 Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met Ser Glu Val 900 905 910 Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val Lys Pro Leu 915 920 925 Leu Phe His Lys Lys 930 <210> 40 <211> 6455 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..6455 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 40 gagttgtgcc tggagtgatg tttaagccaa tgtcagggca aggcaacagt ccctggccgt 60 cctccagcac ctttgtaatg catatgagct cgggagacca gtacttaaag ttggaggccc 120 gggagcccag gagctggcgg agggcgttcg tcctgggact gcacttgctc ccgtcgggtc 180 gcccggcttc accggacccg caggctcccg gggcagggcc ggggccagag ctcgcgtgtc 240 ggcgggacat gcgctgcgtc gcctctaacc tcgggctgtg ctctttttcc aggtggcccg 300 ccggtttctg agccttctgc cctgcgggga cacggtctgc accctgcccg cggccacgga 360 ccatgaccat gaccctccac accaaagcat ctgggatggc cctactgcat cagatccaag 420 ggaacgagct ggagcccctg aaccgtccgc agctcaagat ccccctggag cggcccctgg 480 gcgaggtgta cctggacagc agcaagcccg ccgtgtacaa ctaccccgag ggcgccgcct 540 acgagttcaa cgccgcggcc gccgccaacg cgcaggtcta cggtcagacc ggcctcccct 600 acggccccgg gtctgaggct gcggcgttcg gctccaacgg cctggggggt ttccccccac 660 tcaacagcgt gtctccgagc ccgctgatgc tactgcaccc gccgccgcag ctgtcgcctt 720 tcctgcagcc ccacggccag caggtgccct actacctgga gaacgagccc agcggctaca 780 cggtgcgcga ggccggcccg ccggcattct acaggccaaa ttcagataat cgacgccagg 840 gtggcagaga aagattggcc agtaccaatg acaagggaag tatggctatg gaatctgcca 900 aggagactcg ctactgtgca gtgtgcaatg actatgcttc aggctaccat tatggagtct 960 ggtcctgtga gggctgcaag gccttcttca agagaagtat tcaaggacat aacgactata 1020 tgtgtccagc caccaaccag tgcaccattg ataaaaacag gaggaagagc tgccaggcct 1080 gccggctccg taaatgctac gaagtgggaa tgatgaaagg tgggatacga aaagaccgaa 1140 gaggagggag aatgttgaaa cacaagcgcc agagagatga tggggagggc aggggtgaag 1200 tggggtctgc tggagacatg agagctgcca acctttggcc aagcccgctc atgatcaaac 1260 gctctaagaa gaacagcctg gccttgtccc tgacggccga ccagatggtc agtgccttgt 1320 tggatgctga gcccccgata ctctattccg agtatgatcc taccagaccc ttcagtgaag 1380 cttcgatgat gggcttactg accaacctgg cagacaggga gctggttcac atgatcaact 1440 gggcgaagag ggtgccaggc tttgtggatt tgaccctcca tgatcaggtc caccttctag 1500 aatgtgcctg gctagagatc ctgatgattg gtctcgtctg gcgctccatg gagcacccag 1560 ggaagctact gtttgctcct aacttgctct tggacaggaa ccagggaaaa tgtgtagagg 1620 gcatggtgga gatcttcgac atgctgctgg ctacatcatc tcggttccgc atgatgaatc 1680 tgcagggaga ggagtttgtg tgcctcaaat ctattatttt gcttaattct ggagtgtaca 1740 catttctgtc cagcaccctg aagtctctgg aagagaagga ccatatccac cgagtcctgg 1800 acaagatcac agacactttg atccacctga tggccaaggc aggcctgacc ctgcagcagc 1860 agcaccagcg gctggcccag ctcctcctca tcctctccca catcaggcac atgagtaaca 1920 aaggcatgga gcatctgtac agcatgaagt gcaagaacgt ggtgcccctc tatgacctgc 1980 tgctggagat gctggacgcc caccgcctac atgcgcccac tagccgtgga ggggcatccg 2040 tggaggagac ggaccaaagc cacttggcca ctgcgggctc tacttcatcg cattccttgc 2100 aaaagtatta catcacgggg gaggcagagg gtttccctgc cacggtctga gagctccctg 2160 gctcccacac ggttcagata atccctgctg cattttaccc tcatcatgca ccactttagc 2220 caaattctgt ctcctgcata cactccggca tgcatccaac accaatggct ttctagatga 2280 gtggccattc atttgcttgc tcagttctta gtggcacatc ttctgtcttc tgttgggaac 2340 agccaaaggg attccaaggc taaatctttg taacagctct ctttccccct tgctatgtta 2400 ctaagcgtga ggattcccgt agctcttcac agctgaactc agtctatggg ttggggctca 2460 gataactctg tgcatttaag ctacttgtag agacccaggc ctggagagta gacattttgc 2520 ctctgataag cactttttaa atggctctaa gaataagcca cagcaaagaa tttaaagtgg 2580 ctcctttaat tggtgacttg gagaaagcta ggtcaagggt ttattatagc accctcttgt 2640 attcctatgg caatgcatcc ttttatgaaa gtggtacacc ttaaagcttt tatatgactg 2700 tagcagagta tctggtgatt gtcaattcat tccccctata ggaatacaag gggcacacag 2760 ggaaggcaga tcccctagtt ggcaagacta ttttaacttg atacactgca gattcagatg 2820 tgctgaaagc tctgcctctg gctttccggt catgggttcc agttaattca tgcctcccat 2880 ggacctatgg agagcagcaa gttgatctta gttaagtctc cctatatgag ggataagttc 2940 ctgatttttg tttttatttt tgtgttacaa aagaaagccc tccctccctg aacttgcagt 3000 aaggtcagct tcaggacctg ttccagtggg cactgtactt ggatcttccc ggcgtgtgtg 3060 tgccttacac aggggtgaac tgttcactgt ggtgatgcat gatgagggta aatggtagtt 3120 gaaaggagca ggggccctgg tgttgcattt agccctgggg catggagctg aacagtactt 3180 gtgcaggatt gttgtggcta ctagagaaca agagggaaag tagggcagaa actggataca 3240 gttctgaggc acagccagac ttgctcaggg tggccctgcc acaggctgca gctacctagg 3300 aacattcctt gcagaccccg cattgccctt tgggggtgcc ctgggatccc tggggtagtc 3360 cagctcttct tcatttccca gcgtggccct ggttggaaga agcagctgtc acagctgctg 3420 tagacagctg tgttcctaca attggcccag caccctgggg cacgggagaa gggtggggac 3480 cgttgctgtc actactcagg ctgactgggg cctggtcaga ttacgtatgc ccttggtggt 3540 ttagagataa tccaaaatca gggtttggtt tggggaagaa aatcctcccc cttcctcccc 3600 cgccccgttc cctaccgcct ccactcctgc cagctcattt ccttcaattt cctttgacct 3660 ataggctaaa aaagaaaggc tcattccagc cacagggcag ccttccctgg gcctttgctt 3720 ctctagcaca attatgggtt acttcctttt tcttaacaaa aaagaatgtt tgatttcctc 3780 tgggtgacct tattgtctgt aattgaaacc ctattgagag gtgatgtctg tgttagccaa 3840 tgacccaggt gagctgctcg ggcttctctt ggtatgtctt gtttggaaaa gtggatttca 3900 ttcatttctg attgtccagt taagtgatca ccaaaggact gagaatctgg gagggcaaaa 3960 aaaaaaaaaa agtttttatg tgcacttaaa tttggggaca attttatgta tctgtgttaa 4020 ggatatgttt aagaacataa ttcttttgtt gctgtttgtt taagaagcac cttagtttgt 4080 ttaagaagca ccttatatag tataatatat atttttttga aattacattg cttgtttatc 4140 agacaattga atgtagtaat tctgttctgg atttaatttg actgggttaa catgcaaaaa 4200 ccaaggaaaa atatttagtt tttttttttt tttttgtata cttttcaagc taccttgtca 4260 tgtatacagt catttatgcc taaagcctgg tgattattca tttaaatgaa gatcacattt 4320 catatcaact tttgtatcca cagtagacaa aatagcacta atccagatgc ctattgttgg 4380 atactgaatg acagacaatc ttatgtagca aagattatgc ctgaaaagga aaattattca 4440 gggcagctaa ttttgctttt accaaaatat cagtagtaat atttttggac agtagctaat 4500 gggtcagtgg gttcttttta atgtttatac ttagattttc ttttaaaaaa attaaaataa 4560 aacaaaaaaa aatttctagg actagacgat gtaataccag ctaaagccaa acaattatac 4620 agtggaaggt tttacattat tcatccaatg tgtttctatt catgttaaga tactactaca 4680 tttgaagtgg gcagagaaca tcagatgatt gaaatgttcg cccaggggtc tccagcaact 4740 ttggaaatct ctttgtattt ttacttgaag tgccactaat ggacagcaga tattttctgg 4800 ctgatgttgg tattgggtgt aggaacatga tttaaaaaaa aactcttgcc tctgctttcc 4860 cccactctga ggcaagttaa aatgtaaaag atgtgattta tctggggggc tcaggtatgg 4920 tggggaagtg gattcaggaa tctggggaat ggcaaatata ttaagaagag tattgaaagt 4980 atttggagga aaatggttaa ttctgggtgt gcaccagggt tcagtagagt ccacttctgc 5040 cctggagacc acaaatcaac tagctccatt tacagccatt tctaaaatgg cagcttcagt 5100 tctagagaag aaagaacaac atcagcagta aagtccatgg aatagctagt ggtctgtgtt 5160 tcttttcgcc attgcctagc ttgccgtaat gattctataa tgccatcatg cagcaattat 5220 gagaggctag gtcatccaaa gagaagaccc tatcaatgta ggttgcaaaa tctaacccct 5280 aaggaagtgc agtctttgat ttgatttccc tagtaacctt gcagatatgt ttaaccaagc 5340 catagcccat gccttttgag ggctgaacaa ataagggact tactgataat ttacttttga 5400 tcacattaag gtgttctcac cttgaaatct tatacactga aatggccatt gatttaggcc 5460 actggcttag agtactcctt cccctgcatg acactgatta caaatacttt cctattcata 5520 ctttccaatt atgagatgga ctgtgggtac tgggagtgat cactaacacc atagtaatgt 5580 ctaatattca caggcagatc tgcttgggga agctagttat gtgaaaggca aatagagtca 5640 tacagtagct caaaaggcaa ccataattct ctttggtgca ggtcttggga gcgtgatcta 5700 gattacactg caccattccc aagttaatcc cctgaaaact tactctcaac tggagcaaat 5760 gaactttggt cccaaatatc catcttttca gtagcgttaa ttatgctctg tttccaactg 5820 catttccttt ccaattgaat taaagtgtgg cctcgttttt agtcatttaa aattgttttc 5880 taagtaattg ctgcctctat tatggcactt caattttgca ctgtcttttg agattcaaga 5940 aaaatttcta ttcttttttt tgcatccaat tgtgcctgaa cttttaaaat atgtaaatgc 6000 tgccatgttc caaacccatc gtcagtgtgt gtgtttagag ctgtgcaccc tagaaacaac 6060 atattgtccc atgagcaggt gcctgagaca cagacccctt tgcattcaca gagaggtcat 6120 tggttataga gacttgaatt aataagtgac attatgccag tttctgttct ctcacaggtg 6180 ataaacaatg ctttttgtgc actacatact cttcagtgta gagctcttgt tttatgggaa 6240 aaggctcaaa tgccaaattg tgtttgatgg attaatatgc ccttttgccg atgcatacta 6300 ttactgatgt gactcggttt tgtcgcagct ttgctttgtt taatgaaaca cacttgtaaa 6360 cctcttttgc actttgaaaa agaatccagc gggatgctcg agcacctgta aacaattttc 6420 tcaacctatt tgatgttcaa ataaagaatt aaact 6455 <210> 41 <211> 412779 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..412779 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 41 atggtcataa cagcctcctg tctaccgact cagaacggat tttaccaaaa ctgaaaatgc 60 aggctccatg ctcagaagct ctttaacagg ctcgaaaggt ccatgctcct ttctcctgcc 120 cattctatag cataagaaga cagtctctga gtgataatct tctcttcaag taggtactcc 180 tatttcttct caatttattt tttccttttt gatataatgt gctactgttt acaagcatat 240 tgtaacttca gagcttacct ctcatcttta aaaaatgttc atttttttgt ctttctgctc 300 caaggatatt ttgcaaagtt actggcaagt attcctggga tgataaaatg tgaaatctaa 360 acttggtaca gtggaaattc acttctagaa taatatttag ctgaggcaga gggcaatccg 420 actacccttt tcttagtaca gcacacacag gctgcctgtc tgttccagat aacataaatg 480 tattggatct agcactagct aggagacact gtattgttga actgtgttag aattttataa 540 gctcttaatt ggacaaatct cagagtagca tgaacacact acctgttttc tgaatctttg 600 gagccataac ttacgtgagt ttgaactaag cgatgtgaat aagccattat ttgtttccta 660 aaggcagtca agttttctga aaagctacac atttagcagc aaaagaacga gcccctctgt 720 cttgaaatgg gcctctgatt ttaagcaagc tcttttgagt cctggtgtcc cattttctca 780 gttccttttt gcctcacaat ggcacataca taatgactcc accacatata gcagtgggct 840 actcgggtaa tgatgtggca gtcacaagac agggcagaat actttcattt tggttagagg 900 aatgccacat gtcttaggaa atgctcgctg aactgtaagt ttcatacttt gtcaagaaga 960 taaccagtat tctctcaaac aagtccgtag gagccaacat gattaaaaga ttttaaagca 1020 atttactcga tagaagggtt gggcttaatc aggacttgtg atcatggcaa tggttcctgc 1080 ttaaaggtgc cagattttta atgcctttat gtgccagatc taataggctt acagagcaac 1140 tccatgtata tgaggttgct gggaaactca tctggttttg aatgtggtat atacatattt 1200 taatattgag agtaaacagg aagaccaggt agaagtattt gaactgaatt ctgaaacgta 1260 cagagaactt aaattggatg agaatgtttg agaaccatgg atggttcagg gtccatttgt 1320 ataccataaa atcccttcct atttctcaaa agcaaatatt ttctttgatt ttgttaatat 1380 cctgtgatga ctgcccacta ggccttggaa tgcatgcaga taatgctgta gcagttggat 1440 aaaatactct agaatgtcag attttcaagg aaattacaaa taaaaacaat gtaggtaaaa 1500 gatacgacat gtaggaaaaa agcaaaattt tccttaagaa tacaagcgtc gtatttacga 1560 gtagaagatt tttcttggac atttggagat acgtgtttca ttttattgct tgtgacagtc 1620 aaggaaagga ataaagctct tgtgtcttaa acttgcagca agaacaaagt ccaactatct 1680 ttcgtttctg ataactctgt gtctttttgt tcaatattgg gtttagagct agctaccatc 1740 taccttccct tcaaacactc actctaaacc tccacacagt gtaagtattt acatcaggca 1800 tctgctaaac attttcacat ggttatctgc aggtcttctc tgagtctgtc tgcattcatt 1860 tatcctagtt gctcagaaca atcgcttggg ctgacggcct ggtggttgag tttactttgc 1920 tttgaatagg gaacagctgt gctccaggac tgcagattgg ctattcggaa aaaagggcaa 1980 ggaagagagt gacccagctc tgggtagacc atccacactg taaaaaaaaa agtcatagca 2040 tagtcttcat ctatggcagt ggagatatgg tcctgtccat ccacctctat caggagaggg 2100 tctccattgt taatctccga gaaagaggcg ccatctgtga aacctcctgc atattgtcta 2160 atgaagtgct attttgaaag gcgtgcactg tacaggtaag agtgatgatg gtgtgcctgc 2220 cttctgggca acatctcagt agacttcctc tgaatcattc ccactggacc caacagcaaa 2280 agcgtacaca tcattgagtt ttatcgttct atctaaggcg tataacattt ttctctctga 2340 aagtctgtga ttctttcgga gaatgaaggg gcttacccta tccatctgcc cctaaaaata 2400 ttcgctggaa agctgatacc tctgctcagg ttttccacag cagatcactc ttcagtaaga 2460 attctgatat taagtagttt aattcagatc catggaaaat gactgagtac cagccatagc 2520 tcccaccact ctctagctgt gcaatttaga ggcagattat ttaacctcat gccttgaatt 2580 tctcatctgc aaagtgggag tactaacagt agctaccaga tatattatat ggaataaatg 2640 acattaagcc actcattaaa ctccttgcag tttccaagca ttagaaactc agtatgagga 2700 agttatttct attctaagcc tagcacagtg cctggtactc aatacatgtt ggttgaatca 2760 gtgaaataat tcaaggtcag caccaaagct gctaggaatt tatgaacatc tgatcataac 2820 tggaaacttg atctaaaaag caaagggcag tcaatccaat caactgagcg taccatctgt 2880 tgaaatgctg ctgcttctgt aatgagtata aagtgttgga agagaaagtc caggaacctc 2940 catcattctt ccatcattcc tctcctttgt gactatcttt gtgatgagaa gggtaacaaa 3000 aaaatcttgc tgagatgagc gtgtcaaaaa cgtgttacaa atgcttcaca ttccctttca 3060 catcaacaga agcatgttgc ttcattgttg ggcaatgtct tagtccatac acacatagag 3120 ctctatgctg attttttttt gagatggagt ctcgctcttt caccgaggct ggagtgcagt 3180 ggtgctttct cagctcactg caacctccgc ctcccaggtt caagcaattc tcctgcctca 3240 gcctccagag tagctgggat tacaggcatg tgccaccatg gccagctaat tttcatattt 3300 ttagtagaga cggggtttta ccatgttggc caggctggtc tcaaactcct gaccttaagt 3360 gatccactcg ccttggcctc ccaaactgct gggattacag acgtcagcca gcatacccgg 3420 ttgtatgctg atgttctaat tcaatgtgat accaaagacc tgagatagtc tctcccactc 3480 tggccccata acatatgtcc acgaggtggt aataataaca actatagtag cacctaaggt 3540 tggggcagct cttactttgt gcgatgcttt ttatagtgtt attacgtgtg attctcacag 3600 caaccccagg tggtgaacaa cgttatgatt cctgttgtac aaatgaggaa actaaggctt 3660 tgcaaagcta ggtaacatgc ccaatattac acagcttcaa aagtgacagc cctaggactt 3720 gaagataaac tcatctaatt ccaaagctca tgcttttagc cattacttga gacagtatta 3780 acttttaaag tttgtaatca atatgaattt ggccttggga aagcaggtta agcatctggg 3840 gttgatggga gataacatta caccctctct tagcctcagc aacttcatct gtaaaatggg 3900 aataattaca tccgagtcac agaagttttg tggctcttca tgaggattaa ataaagtaat 3960 gcatgtaaaa gagttttgta caaagttcac ttttataaaa tgcaagttgt ggccgggatt 4020 ggtggttcac gcctataatc ccagcacttt ggggggctga ggtgggtgga tcacctgagg 4080 tcaagagttc gtgaccagcc tggccaacac ggtgaaaccc gtctccacta aaaatacaaa 4140 aattagccag gagtggtggc atgggcctgt aatctcagct acttgggagg ctgagactgg 4200 agaatcgctt gaacccgcga agtggaggtt gcagtgagcc gagattgtgc cattgaactc 4260 ccacctgggc aacagagtga aactgcatct aaaaaaagac aaaaaaaaaa aaagtaagtt 4320 gttatatgca atgcataaat tattacttag ttccatgtaa aatcttccca ctaagtgaat 4380 gagggttcac ctggctgtag tgctatgaga tagatatgag gggcagattg gtttatgctt 4440 ctcaaaaaca gaaagtgtgc cagggtggaa gtgtgggtgg ggagtctccg cctcccagcc 4500 atgtggcaaa gctggaatgt gagtacagca gcagtatgga tgcggttttg aggggatggt 4560 ggtaatcctc ttctggcggc acccctccag tattgtggga tgctctctga tttcttttga 4620 gaagacaagt agctaggagc ttccctagcc tttctgttgt aaaaaccatc aagatccctg 4680 ttgaatgcat acctggagct tggtttccct aagcacagac tttaataact tcatttggat 4740 ttagtctcct atttaaagct gccacccact ctcaattttt tgggttttcc tactaagaat 4800 ggatataaca tgggcagtct tccagttctc ctttcttgct gccttgaaga caacacacag 4860 gccaatcaca aggaggcaga gacaggcccc aacaagttga caatcctaga gagcttagtg 4920 tgagtagact tgctgaggtt cctgactttt gctggaatag gagagtgcca ctggcttttt 4980 gacatttctt tttccaactg tttccttgtc aaaatgacca gcagctcagc tcccctaaac 5040 atacctcctc ccctagattg gttcagagga agccatcaag gtccttttgc aaacggatga 5100 tctgcatttt tgagatcctt ctttcctctg ctgttcatag aaatggtctc attggaataa 5160 ttccttttgg aacgttacta aggacaccaa gaaatcaaca agaaaatttg agtgtatctg 5220 acagaagaaa tttggctttt gtactctaat aattatttat tagaagcaat aactggtcag 5280 aatttatttg cttaaaacca tgtaaagaaa ggtgcttaat aaagataatt gcatcacata 5340 tagtaatccg ttttagtatc tttcacctta aaactatgtg acaaataaag acacaaattg 5400 ctctttcttt ctaataagca attttggaaa ttccttattg ggaaattcca aattttacaa 5460 aatttacaaa atttaaaatt ttggaaatcg tacctgcatc aagttttctg aaagaatatt 5520 taaggattaa ggttacttag aatccaatat atgcatagtt taatttaact catattgtta 5580 aattcttttt ctaattttat ttaagaaatg agtaatattg acaagggcct tgctgtggtt 5640 tattatggct tgtcctagag tctctattcc cagctagatt aaaagtgcct cagggctggg 5700 catggtggct catgtctgta atcccaatat tttgggaggc tgaggccagt gaatcagttg 5760 aggccaggag tttgagacca gcctggccaa catagtgaaa tgctatctct actaaaaata 5820 caaaaaatta gccggacatg gtggtgcatg cctgtaatac cagctacttg ggaggctgag 5880 gcaggagatt cgcttgaacc tgggaggcgg aggttgcagt gagctgagat aacaccactg 5940 cactccagcc tgggagacat agagagactc catctcaaat aaataaataa ataaataaat 6000 aaataaataa ataaataaat aaataagtag tgcctcgggt gcatagatgg ggttgttcag 6060 ttttctaccc tgtgccttgg gaagtgcctg gtacacactg gtgtttggca cataattgta 6120 gagtgagatt gagcctggca tgttccttga tccctagaca atctctatca ggtgtgatca 6180 gtaaggcaca taatatgata tgtgactatt acagagtagc acactacaat atgtgcctaa 6240 agccataaca tcaactaata caattcagca gagtagaatg tgaagagtgc ttgcagagtg 6300 ctgagcacca cggtgaggaa gtgtaaacag aagaaggtat ttctgggttg gtgcaggatg 6360 gttagggata gctttgggta ggaagcgact cttgaccatg accttaaagg acaggtaatg 6420 tttacatggg aaaatacaag gaaaaggagg tgcataatga aaggcatggg ggaggtggtt 6480 ttgggaaacc atcagtctga cagaaacata gttaagaaaa gtgcaaggtg gtggtaggag 6540 gtaatttaga agtggagagt cagatgtcct attaaggagc ttgaacttta tcttgtaggc 6600 attaaagatg ttggtgtagg attggaatga aataaagact taaccttaga aaaatactgt 6660 gtggattgaa gttttcagat gaagagtggg tacatcaatt cggaggtgag ggaaatagtt 6720 caagggaggt gtcacaccat taaaaaaaat cttttaggac ttgttttttg caatcatgat 6780 tgtttatggt tgtaaagatt ttgtttcaga aatgattggt ggagaaagaa gtgtattgag 6840 aatcaaaaga tgggactgtg ccactgatgt gcgcagtgag aagctgcaag cttggtgccc 6900 catcttccta actgtaaaat gggcataaca actaccagac agccgtcaaa acattatact 6960 agtgatacaa tgaagactaa gtgatataat tttgaaaggc agtatgcctt atatgtgtaa 7020 aatgctgttt acttggaata tttttatagt aaaattattt tctttggaca agatatagat 7080 gcagaagaaa atgatcatat ttctgtgaga ttaggattca gaccatttga attttttata 7140 tttattaaat aggtacttta tgttgggtac tgaataagtc ttttattttt aacacctcat 7200 ttccctcaca aaatggatgg catctttgga ctaggggaaa tgtgtggtcc ctgcagctgt 7260 agtattttat gattctatag cttttgcctt tagcaaactt ctcttagaat agtgatttaa 7320 gggctgggtg tggtggctta cacctgtaat cccagcactt tgggaggctg aggcaggcag 7380 atcacctgag gtcaggcatt cgagaccagc ctggccaaca tggtgaaacc ccttctttac 7440 taaaaataaa aaattagccc cgtgtggcag catgcgcctg tagtcccagc tactagggag 7500 gctgaggcaa gagaatcgct tgaaccggga ggtggaggtt gcagtgagcc aatattgtac 7560 cactgcactc cagcctgggc gacagaacat ttaatgctgg tggctcacac ctgtaatcct 7620 agcactttgg gaggccgagg tgggtgaatt gcttttgctc aggagtttga gagcagtctg 7680 ggcaacatgg cgaaacccca tctctataaa aaatacaaaa attagccagg tgtggtggtg 7740 cacgcctgta gtcccagcta cttgagaggc tgaggtgaga ggatgactta agcccaggag 7800 atccaggctg cagtgagctg acatagcgcc actgcacact gcattccagc ctgggcaaca 7860 gagcaagatc ttgtcttaaa aaaaaaaaaa agtgacttaa gatactgaca gtataaacac 7920 aaccaaaccc atgggcatct gtgctgggaa taaaagacag acatgttttc attgcactga 7980 tttaggattc tgcttggaaa ggaaaactgt gatctctcct gcagttgcct aaaatgcttt 8040 acagttatgg gaatggaaaa gctaaattct gtgatttgtg ggtagaggga aggaggacga 8100 gtgtcctttc tgatttcctc tttttccttc tcttccaagg ggaaataaaa ggctagagca 8160 acaatttaaa aagaaaaggc aaggagctac tgggggtaga gtcgggaggg aaaaaggcca 8220 aacccactaa ataatttcac ttcagttaca gtaaatctca aatgatgatg ctacactcct 8280 gagaatgttc catggtggaa atgcctgggc tttgaatttt gagcagcgaa gtaccaggag 8340 agggtgacat gataacattc aacaggaaga acactgctct tgtccgtttg acggtcctat 8400 tcctccggat cactcaatct tcacaaatca agcatatagc tccttcacat gtcatttgtg 8460 aagggaaaga ctcctaggaa aatgttttct aggaaaggga aaaaagcaga aagcaaaggt 8520 ctcctgctta ctacagcatt cgtgttgcat aagcagtatt aatgtagtgg agtattaatc 8580 acttagaaca gttcacgtat tattcctatc tgggctctgc agggtccttt cttcacttct 8640 ttctcgacat ttggattctg tccattttac tcctccctct gcacttggaa tagaagtgaa 8700 atttgttgtg ccaattctct gcttgttaga agccatggta atgtttagta ggggaaaaga 8760 tttgtactgc tacatagaag gaggttttgg gattatttaa gactttactt tgttgatggg 8820 attcctagaa tctactatta ctgggtatac tagacaagtt tgtagattta caaaagtgtg 8880 gataacatgg gttgcacttg atttctttat ccagctcttt ggttctaaat ttattgccaa 8940 ttttatttat caaaactatt ctcagcggag tagtattttc tgtggacaca aggaaacatc 9000 tgtgagctta aaccttagag gcagatagcc agttagaaca tttggcatat gaagcttaga 9060 tagcagaaga gaaaaattaa ccaaggcaac cctcaaaaat attgagaagg caactaagaa 9120 aaatttctta tcactgacag actgcagtat tgagttcgtg ttaatgaaga aatgtcagaa 9180 tacataatga atcaataagg agtgtcatat tatggcaagt ttcaatgttg gtgtcaatct 9240 cgactgccag gatttatggt agattatata atggaatcct gagttctgag agatcaaagg 9300 aaaatgctgg ctctttcttc atccattctc ttaggtcaag cctatgcagc aagaagccaa 9360 gttgagaatt gagcaattat ctgaagtggg cagtggagac ggccaaacca gataatatat 9420 aaccagaaag tcaccgtgga gggaaaatgt ggactgaaaa taggataagg ggtggaggta 9480 gaatgtcaag ccatttggtc agtgtccaca gtccaaattt actgaataac agccaattcc 9540 ttacttcatg tggttattta gagcgagact agaggacaag tgaaaaaaaa aaaaaagagt 9600 tcattcctaa ggttgttgca tgtttgtgca aaatttcttc aaatctctgt tattatctgt 9660 tacatgtcta attctgagta cttccagaga ttgcatttca ttactttaga ttagtgggtt 9720 gaagtggtgg aggaagccca tataatctga cttacatgga gaaaacaagt ctttttttat 9780 agtttagttg agtgttatat ttaattagcc tttttttccc tccataatgc atgcttatga 9840 attttccact taaaattctg aggctctgac ctttatcatt tcctcatgga gcaatttctg 9900 tacctcctta actttagtag aacatagcaa tgaaatatac aagtccccta gaatagaatt 9960 tgtgtgaatt tggttttcta aaaacacaac taccaaagtc tgaggaccag tgtggtattt 10020 ttttcttcta tttgatatgg aaaccataaa ctacttactt tgagcagatg tttcccagtc 10080 ctaaaataca gctatcagtc cactggcccc tataaatctg ttggagtgca cctgctaatt 10140 ctgaagcctc cctaatacaa tgttaaactt tccttttttt tttttttttt tttttgagaa 10200 aaaaattgta aattaggttc actgttgctt ggaattagga aaaaataaaa acacaggcat 10260 actaatattt cagatggaaa aacaaagtta agaattcaac aagttttttt cccccactct 10320 atcatgtctt gcacatttaa agctgttata caacatttta aaaacaaacc aaaaaaaccc 10380 agggcctttt tccaacagct taggctgatg acccacagta aaaaagtgcc ccatgggata 10440 ttcttaaagc accccaaggg agtctattga aataacttaa agtaaaaatt cagaagaatt 10500 ttacatgtaa ttaaaaatta agaacgttgt tttataagca atagggaaaa gctgtattaa 10560 gttgcattgc tcaatttctc acttgctctg tgcagtgact gctttttcaa ccatgtaaca 10620 acgtctgaat cttcgtggta aaatcatacc tatcacagcc acagcaggtt ttgttctgct 10680 gctgcacatg tgatttgaga tactgtgggc tgggagtttt ttttttttta atttctaatg 10740 gcaaaatgga tctatagaaa tggaagtcat ctgtaatctc agcactttga gaggctgagg 10800 tgggtggatc accggaggtc aggaattgga gaccagccca gccaacatgg tgaaacccat 10860 ctctactaaa aagataaaaa attagctggc gggcgtggtg gtgtgcgcct gtagtcccag 10920 ctacttggga ggctgaggca gaagaaatgc ttgaacccag gaggtggagg ttgcagtgag 10980 ccgagaccgc accgttgcac tccaatctgg gtggcaagag cgacactaca tctcaaaaaa 11040 aaaaaaaaaa aaaaaaagaa gaagaagaaa tggaagtcat cccgtgggcc tgagttggtg 11100 tagtggatta tggcctgtgc gtgaatgaag aaatacttgc caatggcatc agtggtaact 11160 agcttaagcc ctactcagct ttgtaaaata atgtaatcaa ggaatttgat ctgaacaggt 11220 aagccaaaca ttgattcttc agtgcctatt gataagtgag actacttttc tttttaacag 11280 ccttatttca cttaagtggg gagtcaaact agctttaatt aaggaaatct gtagaaatca 11340 cccacatctc cctttccttc tctgttaaaa aaacaaaagg aagaagaaaa ctaggaagga 11400 gtaagcacaa agatctcttc acattctccg ggactgcggt accaaatatc agcacagcac 11460 ttcttgaaaa aggatgtaga ttttaatctg aactttgaac catcactgag gtatgtgtga 11520 acatactagt ttcctctttc tctctcctga ctttgtccgt gaattgataa gatctaattt 11580 ggtcatcagt ttggagaacg atttttcatt taatttcttt cattatcaag tgtgtattgt 11640 caggggctta gcagtacacc tactatctga tgggcactct acatgcgttg cttaggttga 11700 aattaaggat acaatctgtg cactaccacc atttaaaaaa atccccaagt ctactgtgtg 11760 ggtgaggttt ctttgcatag tatcagagag gttaaccaat ttatttacat actcaatagt 11820 ccactctaag tagggaaaat ccaagctttt tttttcttaa gaaagagctt ttcattcttt 11880 tttccctcag agctttacca tagtttccag caagtgaaaa catttcttga tttgaatttc 11940 acaacctcct tctcctcttg ccagttgtat ggtgctaata ggaagcaaaa tgtgagtgtg 12000 cttttaattt aaccctaaaa taggggaata tcttcagaat ttagacttta catattcagt 12060 gacctaccta aaaatagaga catagttcta accttctcaa tcattaagaa acatttctat 12120 tgaatttaat tattcaaaac aacaggtagc agtttcacaa gggaaaagac aagccatgcc 12180 acttgtattt gtggtcacca agtaattaca ttatttttta tttaaaatta agataaaata 12240 acttactgac tgtcaagtcc atttctcatt tcctccatag aacattttaa aactagttca 12300 caaacctctt gaaaagtcat gcctctagaa agtgcaaatt gtcaccattg cctagaagcc 12360 aacttgagag gctgtgtatc tatgcagcat tttgcaaatc cagtagcagg catgtgatat 12420 aaaagattaa atgcacccct gatttgtgaa tactatccta gccttcaaaa tgttcaaaag 12480 cacaggaagt ctgcactttt aaaaatataa cctgcccaaa ttgcaaggga ggggttgggt 12540 gtaggaccta ggtctgtctg ccaatcagct tgagatgcca gtggacgaaa cctgacttca 12600 ctaaaaacca gactggcaaa tattactcag cgtggtaatt tcctaattgt agaactggcc 12660 tgtttggtga agtatttcag gaaaattttt agctggacct tttctaccct actgcataag 12720 aaatgaaggt ttctaggcaa agactttact tagtgactaa ccaaaaatgg taaataaagt 12780 caccacttcc aggcttagct actgtcctca aaacagctgc aggactggtc aggccagtct 12840 tctgaggctg gaggtgcatg tggaaccccc agagccttgt ctgcaagggc atggctgact 12900 gcaggctgtt tagaagcacc ccgccccgtg aaactcctct ggcttaggaa ttttaaacag 12960 ttctagttct aatctctctg ctcagagtct gagcagctgt gaatgagctc tcctgtgaat 13020 cacagaaatg ttaatgggtg agctgctcta gcttcttact tccaagtgga aggcgcctgt 13080 agctctttgc cagcttgatg cagtgagttt gattcctctt ttgggcagca gggagagata 13140 atgaaggagg gggaaaaaag attttaatat agaaacgagt cttccatctg gctgaggctg 13200 aacaaagtag aagaaccagt gcaagtcact gggggtatgg atctcatacc attttcagca 13260 tatacctccc tttctctctt tttgattcta cacatgtcag tccctgagta gtcttgcatt 13320 gctttcccca ctttgaagtc ttagatccaa aactttgatt ccagaaaggt ctaaggtgct 13380 gttgctgaga ttttgaaaga gacctgagac aaactgttgg gattctagac gctattgcgc 13440 atctgcctgg gtaactgtgt cacttaggtt gggtcaccag aataattctc ctccattttt 13500 gctgcctttc caatttataa acaacacaga acatcagtgg ttctcccata atcaaatata 13560 tttggctcta ttaatattaa aatttgatct tgagtagaaa gattctaagg gctaaaaaat 13620 aaaagatgta aaatgtatgt tgataggtta gtgtagaagc cacccatggg gttgccccca 13680 ctcccactct ttcatatttt ttttaagaaa caacactcaa gttacaaagt cgattctttt 13740 tttgttttgt tttatttgag actgagtctc actctgtcac cacccaggct ggagtgcagt 13800 ggtgcgatct tggctcactg caacctctgc ctccccggtt caagcgattt ttcctgcctc 13860 agcctcccaa gtagctggga ttacaggtgc ccgccaccac acccagctaa tttttgtatt 13920 tttagtagag atagagacag ggtttcacta tgtttcacca tgttgaccag gctggtcttg 13980 aactcctgac ctcaggtgat ccacccgcct cagcctccca aagtgttggg attacaggcg 14040 tgagccaacg cccctggcca caaaagtcaa ttcttaactt aaaacataaa agttccattt 14100 cttttatggt ctacttagtc atgtctggag tcagtgagct cagtcaagta gtttgcagaa 14160 tgacagttgt gatacctatt catttaccca ccagattatt ttctgctctc catggcactt 14220 tatagaaaac agtttattcg gtcattacaa cagctctagg agggggtttc attaaaccca 14280 ctttctagga aagcgaacta aggcttagaa aaatcaagta atttgctaaa gactacccag 14340 ctggcaatga tatgacagga catgaactta ggacaataac tcaaggtctt ggtccctgta 14400 aatatgggtt tccaggttat gtatgcaggc agagggctta gatcctgaag tttccttcag 14460 aaacttcagg atctaagccc tctatatagg agcagtataa aaaggaagga tctcttccca 14520 tagggagctt gtcatccatt gaatgaggaa ctcagacttc cactgtgaaa tgatatttgt 14580 atccccattg tgtgcgagat atggggactc tgatcatcat aagagcacat ttttcctgcc 14640 tataaatgat acttaataga gctgacagat tatatatatc tggaacactt ttacctagca 14700 gaaagacaac aggctaggat tagctgacta ataattttat ttatcaagct caattcccat 14760 gctgacttct cttcctctag tgaaaatgtg tcatcagatt tggtcccaaa ctggagaggt 14820 gaaaggatcc tttgaccagt ataatagcca tgccatcagt tttgctttcc taattaagtt 14880 ttatatgggt taatgatcta tatcattatt ttgggggttt ctaaacacat atgaactaaa 14940 gatggaaaag atgatggaaa agatggaaag aagatgactc agatgtacaa aggcttgcag 15000 agagaaggat aagccaaaaa attggtaaat cacacatgaa taatcaagaa ctgactacaa 15060 tataataata tgtgtccatt tccactaatg aataagctgc cattatgtct cttcattctc 15120 tatttaggac aaattacttc tctgctgtat ttccattctt acaggtacct atctgctgtg 15180 atttttccca gttttgactt tatcttgttg ctttaatctt gtctctaagt aagctgcaac 15240 ccagtaaata tattccagta ttgtttattg taattcctgc ctttatgtca ggtggcaaga 15300 ggaagggact ggttttatta atttatcagt ctgggtgtgt gctaagagga tccttagtac 15360 atgctttgat tatggtagat tgagtctaaa agattcagct ggtttattcc atttattttg 15420 gtctgtctac ctaacaaggt cacacagtgg attatactag ttttctatgt gtcatattgt 15480 tggcctgaca cataatagca aataagaggt accagaattt tctgtacagt ctgaagctgt 15540 gtgtgtacaa caaccagtga aaaatcttag ttatttggac ttttgggttc catgatgcca 15600 gagaaagcca gacaccagca gctggaatca gctaagacct aagaccctgc atgcacatat 15660 agatgtttac attttcttcc tattgcgaca ttcagccatt gctttggcgc ctatttcaat 15720 aatatattgc tgctcatcaa agtggaaata atgttttgtt actagctgag tattgaaaag 15780 ctcttcatag ttttgtgatt ttgactcagc tccaacatgc aggacccatt tcttcaactg 15840 actttggcaa caggagagat tgactagtgg gcttgaaagt gatccactgc tgtttctgtt 15900 taactttctt caatcctact gggtcttggg aagaagaggt agcgggcatc cttgtttgcc 15960 tcaaccagga agcacaaggc catcccaggg cggggcagga gagaggtggg agggaagaag 16020 caggctccac agggccattg tttaccttgt tggcgggtca ggtcttctca gggtagggtt 16080 cctgggataa gagcaaagct tattggtttt ccttgctgtg ccacgagagc acaccagatc 16140 acccctgcag ccttgcttgc cttcccacag cctgcccttg cctagggttt cagctgatat 16200 cctttctact caggaggaga aaccacagaa cacatggagg aagtgtttcc agtgttaaga 16260 ctttagacca aactatagaa atctgttcta cctggaaacc tgaagaaata aatcatgact 16320 gctattcagt agaagtaaaa taaaaaaaca gctttactgg tttggaatca taggaaggct 16380 ttctgtatag cctctctgag agctgcctat tggaaggatt tgtcctcaaa acgtgaggat 16440 ttgtggtgtt ccagggttta tatgacactg gcaggatagt ttgctagagg gctgtgcttc 16500 gacctttatc caagggatgt aagccgtgtg tttaggttag tgagcgtcta gcacaaagct 16560 ctaatgttga aggagcattg gaggcaggct gtgcctctga acatgtagaa ttgactagaa 16620 atgccaatgt tcatttcaaa atgaaatcat tatctttctt atgcttccat ttaaaaatga 16680 ttattacatt tttgcatatg gttgaatgca tattaatttt agcaagttta gaaaagagat 16740 aagcataaag acatacataa aaatcactta ttctcatcag ctatagataa tcactaacaa 16800 tattttagga cattttcttt tcatcttttt cttagcaata tgtatgtgtg tgggtataca 16860 tatttaagtg tgtatatatg taaattaaaa aacataaaat attcccacaa tataattaat 16920 aaaaatctaa gatacaacac aatttccgtt tgtaatatgt agtgtatata tgtatatata 16980 cacattatat gtatatataa aatacatgca taaaatagat acacaggtat atattttgca 17040 aattgaaatg atgttgtatc ttgtagattt tatttaacat tagaatttat ttacactact 17100 taggtgtttt aacaaggatt gtggtccacc atttatttcc ttaagagtaa ttccaaaaag 17160 tggaaataga atgtcaaggg gcaaagttct ttataaagtc cttaaggagt attgccagat 17220 atattttttt ttacttcctt ttaaaacatg attgtattgt agaagttctc tttaaaaatt 17280 ccaagcaaaa atttttcaaa atcccatcta gaaatcaaat catgatttta tttggctatg 17340 cctcttgtag tccttgtcta tgaacttatt ctattattaa atataatagg taatttccac 17400 taatttgaca gatagaattt tattttttac attttctctt gttacagtgc catgcatatt 17460 tctattatgt tacagagatc ttgggggtct tttttcctcc ctttttcctt tctcttttct 17520 tgttctgtac cccttcacag aaaccaacaa atacaggttg atgtgtatcc tctactcttt 17580 tctccatgct cacacaaccc aatatttaca catgcactga tttttcaggg caatggtcct 17640 tctttatcat aaattgtggg ataaggttat atacataata tatgtgtgtg tgtattactc 17700 tgaatcttgg ttttgtcact ttgcaatatg tcttaaagat tctgataaat cttatagatc 17760 tatctcattc ttttcagtag ttgcatgcag tataaattta ctataactta ttcaagtaat 17820 ctgctttcag ctgatactct gttgtgaaca gttttcaaca tataaaaaag tgctgtcatt 17880 acaaatattc ttagatatat attcttagta attgggggtt ttattgttat ggtgtaagtc 17940 ccaggagtag aattgctggt ttaaaaggta tgtgtatttt tacatttcta ttggtttttt 18000 catattattt tctaaaaata ttatagcaaa tcacagtccc actagtgatg ttggagagta 18060 tcattttcct cactagtact cctatttccc tgctttctaa tctttcctga tctaatgagt 18120 aagcattgtt aattttcttt tcattttctt gacttctaat gagcttaagc atcttttcac 18180 attattgttg ttcctttgga ttttcttatc tgtcaattac caatggatat ccttgaccta 18240 tttctccctt atatggttgc ttttctctta ttaaaaattt gtaaaagttc tttgactatt 18300 acagatttta aaaactggca gataaagttg tatgatttat tgtgtataat atgatatttt 18360 gagatataca tatatcttga tatatcaata tcgagatata tatatcacac gttgtggaat 18420 ggctaaatat agctaattaa catgtgcgtt acctcatgaa gttatcattt ttgtggtgag 18480 aacacttaaa acctctcagc atttttcaag aatataatat attgttatta actatagtca 18540 ccatgttgta cagtggatct cttgcactta cttttccgat ttaactgaag ttttgcatcc 18600 tttgaccaat gtctttccaa ccctcacctc ccacccctct gcccgacact gccccagccc 18660 cggtaaccac cattctactc tctatgtcta tgagatcaac ctttttagac tctacatata 18720 agtgagatct tttggtattt gtctttctgt gcctggctta tttcacttaa tataatgtgc 18780 tccaggttca tccgtgttgt tgcaaatgac aatatttttc tcttttttta aggctgaatg 18840 gtattccact gtgaacatat accatatttt ctttatccat tcatctgttg atggatactt 18900 agattgattc tacatcttgg ctattatgaa taatgctgta ataaacatgg gagtgcagat 18960 atggctttga catactgaat acattcgctt tgggcatata cccagtagtg ggactgctga 19020 gtcattcggt aattgtatga ttactgtttt ccatagtggc tgtactaaca taccttccca 19080 ctaacagtgt gcaagggttc tctttactcc gcatccttgc caacactttt aatcttttgt 19140 ccttttcata atacccattc taacaggtgt gagatgatat ctctttgtgg ttttaatttc 19200 cattttctga tgattatagt gatgctgagc attttttcta tagatttttt ttttttggtc 19260 agtggattgc taaatcttac cccgtcaata atttctcctt tgattttact tttataattt 19320 tctgctacaa aattaaaaaa taattgtatg aaataaaatt tttcttccta tacgtattct 19380 gaatttccta tcttacttca aagagtcttc ccacctccta ttttctaaaa ttttcttcta 19440 aaaatttcta tgttttattt tattattttt aatatttagt attttttaca tctggaattt 19500 ttttatataa aagtggaagg ctcaactgca tctcttttta tataaagaac gaattgttta 19560 aacatcacat gttaaataat cttttctcca ataaattaaa ttatattagc atcaatttaa 19620 agattttttt tctctaaacc actaatctat ttatttgttg ccaggcctga gacgtattgc 19680 tttgattata atagctgtat agtctctttt aacatttggc aagtttgatg ctccctactc 19740 attaatatta tttataatgt tagcctggtt ttcctttttt tttttcagtc caaataggat 19800 ttagtcagaa gaaagatacg tggattacat ttttaaaata ctgatcaaaa tgaagatgct 19860 ccaaccgtat aaatggcaga tgaaatagac tttaaagtaa aaaatattta tcacacaata 19920 tatcagaaaa atataacaaa cccgaaccaa caaacatcag caacgtagct ccaaaatatt 19980 agcttgaaac atgaaattgc caatagttga ccactttttg acctacaaaa gcaacaattt 20040 atataaagaa aaggtcaata aaattatggt aaattgaatt tttttttatt attacacttt 20100 aagttctgtg atacatgtgc agaacgtgca ggtttgttac acaggtatac acatgccatg 20160 gtggtttgct gcacccatca acccgtcatc tacattaagt atttctccta ttgctatccc 20220 tcccctagcc ccccaccctc tgacaggccc cagtgtgtga tgttcccctc cctgtgtcct 20280 taggttccca cttatgagtg tggcgtttgg tttgatgttc ctgtgttagt ttgctgagaa 20340 tgatgattgc cagcttcatc catgtcccta caaaggacat gaactcatcc tttttaatgg 20400 ctgcatagta ttccatggtg tatatgtgcc acattttctt aatccagtct atcattgatg 20460 ggcatttggg ttggttccaa gtctttgcta ttgtgaataa tgctgcaata aacatacatg 20520 tgcatgtgtc tttatagtag aatgacttat aatcctttgg gtatataccc agtaatggga 20580 ttgctgggtc aaacggtatt tctagttcta gatccttgag aaattgccac actgtcttcc 20640 acaatggttg aactaattta cactcccacc aacagtgtaa aagcattctt atttctccac 20700 atcctcccca gcatctgttg tttcctgact tttttttttt ttttgagatg gagtctcact 20760 ctgttgccca ggctggagtg cagtggtgca atcttggctc actgcaagct ccacctcccg 20820 ggttcatgcc attctcctgc ttcagcctcc caagtagctg ggactacagg cgcccgccat 20880 catgcccagc taattttttg tatttttagt agagacgggg tttcactgtg ttagccagga 20940 tggtctcgat cttctgacct cgtgatccac ctgccttggc ctcccaaagt gctaggatta 21000 caggcgtgag ccaccgcacc tggcctgttt ccagactttt taatgatcac cattctaact 21060 ggtgtgagat ggtatctcat tgtggttttg atttgcattt ctctaatgac cagtgatgat 21120 gagctttttt tcatatgttt gttggccgca taaatgactt cctttgagaa gtgtctgttc 21180 atatccttca cccacttttt gatggggttg tttgttttct tgtatatttg tttaagttct 21240 tgtagatatt agccctttgt cagatggaga gattacgaaa tttttccccc attctgtagg 21300 ttgcctgttc atgctgatga tagtttcttt tgctatgcag aagctgttta gtttaattag 21360 atcccattcg tcaattttgc cttttgttgc cattgctttt ggtgttttag tcatgaagtc 21420 tttgtccatg cctgtgtcct aaatggtatt gcgttggttt tcttctaggg tttttatggt 21480 ttcgggtctt acatttaagt ttttaatctt gagttaattt ttgtataagg tgtaaggaag 21540 ggatccagtt tcagttttct gcatatggct cgccagtttt cccatcacca tttattaaat 21600 agggaatcct ttccccattg cttgtttttg tcaggtttgc caaagatcag atggttgtag 21660 atgtgtggcg ttatttctga ggcctctgtt ctgttccact ggtttatata tctgttttgg 21720 taccagtacc atgctgtttt ggttaccgta gccttgtagt atagtttgaa gttaggtagc 21780 atgatccctc cagctttctt ttagcatagg attttcttgg ctatacgggc ttttttttgg 21840 ttccatatga aatttaaagt agttttttct aattctatga agaaagtcaa tggtagcctg 21900 atggggatag cattgaatct attaattact tttggcagtg tggccatttt catgatattg 21960 attcttccta tccaagagca tcgaatgttt ttccatttct ttgtgtcctc tcgtttttcc 22020 ttgagcagtg gtttgtagtt ctccttgaag aggtccttca cttcccttgt aagttgtctt 22080 cctacatgtt ttattctctt tgtagcaatt gtgaatggaa gtgcactcat gatttggctc 22140 tctgtttgtt attactgtat aggaattctt gtgatttttg cacattgatt ttgtatcctg 22200 agactttgct gaagttgctt ttcagattaa ggagattttg ggttgagatg atggggtttt 22260 ctaaatatac aatcatgtca tctgcaaaca gagacaattt aacttcctct cttcctattt 22320 gaataccctc aatttctttc ttttgcctga ttgccctggc cagaacttcc aatactatgt 22380 tgaataggag tggtgaaaga ggatatcctt gtctggtgct ggttttcaaa gggaattctt 22440 ccagcttttg cccattcagt atagtattag ctgtgggctt gtcatgaata tctcttatta 22500 ttttgaggta tgttccatca atgcctactt tgttgagagt ttttagcacg aaggggtgtt 22560 gaattttatt gaaggccttt ttttcatcta ttgagataat catgtggttt ttgtcattgg 22620 ttctgtttat gtgatggatt acatttactg atttgtgtat gttgaaccag ccttgcatcc 22680 cagggatgaa gctgacttga ttgtggtgga caagcttttt gatgtgctgc tgggttcagt 22740 ttgccagtat tttatcgagg atttttgcat caatgttcat cagagatatt ggcctgaaat 22800 tttctttttt tgttgtgtct ctgccaagtt ttggtatcag gatgatgctg gcctcataaa 22860 atgagttagg gaggagtccc tctttttcta ttgtttggaa taatttcaga aggaatggta 22920 ccagctcctc tttgtacctc tggtagaatt cggatgtgaa tccatcttgt cctgggcttt 22980 ttttggttgg taggctatta attcctgcct caatttcaga acttgttatt ggtctgttca 23040 gggatttgac ttcttcctgg tttagtcttg ggagggcgta tgtgtccagg aatttatcca 23100 tttcttctgg attttctagt ttatttgcgc agaggtgttt atagtattct ctgatggtag 23160 tttgtatttc tgtgggattg ctggtgatat tccctttatc atattttagt gtgtctattt 23220 gatttttctc ttttcttctt tattagtctg gctagcagtc tatctatttt gttaatcttt 23280 tcaaaaaacc agctcctgtg ttcattgatt tttttttgaa gtttattttg tgtctctgtc 23340 tccttcagtt ctgctctgat cttagttatt tcttgtcttc tgctagcttt tgaatgtgtt 23400 tgctcttgct tctctagttc ttttaattgt gatgttaggg tgtcagtttg agatctttcc 23460 tgctttctct tgtgggcatt tagtgctata aatttccctc taaacactgc tttagctgtg 23520 tcccagagat tctggtatgt tctgtctttg ttctcattgg tttcaaagaa cttatttatt 23580 tctgccttaa ttctgtcatt tacacagtag tcattcagga gcaggttatt cactttccat 23640 gtagttgtgc agttttgagt gagtttctta atcctgagtt ctaatttgat tgcagtgtgg 23700 tctgagagac tgttaggatt tccattcttt tgcatttgct gaggagtgtt ttacttctaa 23760 ttatgtggtc aattttagaa taagtgtgat gtggtgctaa gaagaatgta tgttctcttg 23820 gtttggggtg gagacttcta tagatgtcta ttaggtctgc ttggtccaga ggtgagttca 23880 agtcctgaat atccttgtta attttctgtc tcattgatct gtttaatatt gacagtgggg 23940 tgttaaagtc tcccgctatt attgtgtgag aatctaagtc tctttgtagg tctctaagaa 24000 cttgctttat gaatctgggt gctgctgtat tgggtgcata tatatttagg atagttagct 24060 cttctcgttg cattgatacc tttaccatta tgtaatgccc ttctttgtct tttttgatct 24120 ttgttggttt aaagtctgtt ttatcagaga ctaggactgc aacccctgct ttttttttgc 24180 tctccatttg cttggtaaat cttccgccat tcctttattt tgagcctatg tgtatctttg 24240 catgtgatat gggtctcctg aatacagcac accaatgggt cttgactctt tatccagttt 24300 gccagtctgt gtcttttaac tggggcattt aacctgttta catttaagat taatattttt 24360 atgtgtgaat ttgatcctgt cattatgatg ctagctggtt attttgccca ttagttgatg 24420 cagtttctcg tagtgttgat ggtctttaca atttggtatg tttttgcagt ggttggtacc 24480 agttttacct ttccatattt agtgtttctt ttaggagctc ttgtaaggca ggcctggtgg 24540 tgagaaaatc tctcagcatt tgcttgtctg taaaggatct tatttctctt tcacttatga 24600 agcttagttt ggctggatat gaaattctag gttaaaaatt cttttcttta agaatgttga 24660 atattggccc ccactctctt ctggcttgca aggtttctgc agagtgatcc actgttagtc 24720 tgatgggctt ccctttgtgg gtaacacgac ctttctctct ggctgcactt aacatttttt 24780 ccttcatttc aaccttggtg aatctgacaa ttatgtgtct tggggttgct cttctcgaga 24840 gtatctttgt gatgttctct gtatttcctg aatttgaatg ttggcctgtc ttgctaggtt 24900 ggggaagttc tcctggataa tatcctgaaa agtgttttcc aacttggttc cattctttct 24960 gtcactttca ggtacatcat caaatatagg tttggtcttt tcacatagtc ccatatttct 25020 tggaggcttt gttcattcct tttcactctt tcttctctaa tcttgtcttc atgctttatt 25080 tcaagttgat cttcaatctc tgatatcctt tcttttgctt gattgattca gctattgata 25140 cttgtgtatg cttcataaag ttcttgtgct gtgtttctca gctccatcag gtcatttatg 25200 ttctgctcta aactggttat tgtagttagc aattcctcta tccttttttc aaggttctta 25260 gcttccttgc cttgggttag aacatgcttc ttcagctcag aggagtttgt tattactcac 25320 cttctgaagc cggcttctgt caattcatca aactcattct ccatccaatt ttgttccctt 25380 gctggcaagg agttgtgatc ctttggagga gaagaggtgt tttggttttt ggaattgtca 25440 gcctttttgt actggtttat tctcatcttc atggatttat ctacctttgg tctttgatgt 25500 tggtgacctt tggatggggt ttctgtgtgg atgtcctttt tgttgatatt aatgctattc 25560 ctttctgttt gttagttttc cttctaacag tcaggcccct ctgctgcagg tctgctggag 25620 tttgctggag gtctactcca aaccctgttt gtctgggtat ggaggctgca aaacagcaaa 25680 gattgctgcc tgttccttcc tctggaagct ttgtcccaga ggggcaccca ccagatgcca 25740 gccagagctc tcctgtatga ggtgtctgtc aacccctgct gggaggtgtc tcccagtcag 25800 gaggcacagg agtctgggac ccacttgagc aggtagtctg tcccttagca gagctcaaat 25860 attgtgctgg gggatccgtt tctctcttca gagccagcag gcaggaatgt ttaaatctgc 25920 tgaagctgtg ctcacagccg ccgcttcccc caggtgctct gtcccaggga gatgggagtt 25980 ttatctataa gcccctgact gggactgctg cctttctttc agtgatgccc ttcccagaga 26040 gcaggaatct agagagacag tctggctaca gcagctttgc tgagctgcga tgtgcttcac 26100 ccagtttgaa cttcctggtg gctttgttta cactgtgaca ggaaaactgc ctactcaagc 26160 ctcagtaatg gcggatgccc ctccccccac caagcttgag catcccaggt caagttctga 26220 ctgctgtgct ggcagcgaga atttcaagct catggatctt agcttgctgg gctctgtggg 26280 ggtgggatcc actgagctag aacattggct ccctggcttc agcccccttt tctggggagt 26340 gaatggttct gtctcgctgg cattccagga gccactaggg tatgaaaaac aaaaactcct 26400 gtagctagtt cggtgtctga ccaaatggct gcccagtttt tgcttgaaac ccagggccct 26460 ggaggcatag gcacccaagg gagtctcctg gtctgcaccc aagggaatct cctggtctgt 26520 gtgtttcaaa gaccatggga aaagtgtagt atctgggcag gagtgcaccg ttccttaggg 26580 cacagtccct cagggcttcc cttggctagg ggagggagtt ccctgacccc ttgggattcc 26640 caggtgaggc gatgccccac cctgctttgg ctcaccctct gtgggctgca cccactgtct 26700 aaccagtccc aatgagatga gctgggtacc tcagttggaa atgcagaaat cacctgtctt 26760 ctgcgttaat ctcactggga gctgcagact ggagctgttc ctatttggcc atcttgcccc 26820 ttggtctggt tttcaacctt cagtcttcca tatttatttt gaatgaattt tctgcagctt 26880 tattaaaaaa gaatagaaac aagtaagagc aaagcatagt tggtttatgg ttgtaataaa 26940 cttatatgta tgtcctaatg atttgacagc tttgtgatag tatcttgtaa tccaagtaca 27000 tgatatattt ctacattatt tagatcttgt gttaggtttt tccataagat taattttctt 27060 catattggct ttcttgctat gtttcttttt agcataaagc taatccagga aaaggaataa 27120 aactggaagg aaaaaatgtc ttaaaccatt aatattggct gaccccggtg gtagggttat 27180 gaatgaaaca tttttgcttc ttccactttt ttatattttc caaattgtcc atattaatca 27240 tgtatgattt ttataataat aaattaatga aatttaagaa ttagataatt gattgaattg 27300 gataattgaa ttaataaaat ttaagaatga gaataggaat aattgtgctt tgaaaagtca 27360 tatacacaag agttttagat ggaattcaat actaaattta tatgctatac taaatcagta 27420 attctcaagg agcaaaggtg ctggggagtg tggaggagct ctttgttggt gttgcacata 27480 caatttaaga caacattttc cttattcctc accattttaa ccatatcacc taaccagcct 27540 ctggtagcac tcaatagaca tctgatgaat gaatgaataa gtgaatgaaa acattgtgac 27600 aaaatggtat aacattttgt atttgaaaaa tatatgaaaa tctattcttt tcaaatataa 27660 aatgggaaaa taaaattcaa taaaaatatc ttggttggtg agaatacaca aaagatatac 27720 cttcttgtct atgaattagt aataagaaat tgtcttgagg aagtcaacta catctggaag 27780 gttctctctg gacaaggagc ataagtgaaa aacagtgcac taaattataa ccaagagttg 27840 caacttacca ttttaatgct tcagcacagg cacagagact aacatttact aagcaaacaa 27900 gaagtcttgg caagttaatt aaataatgaa ttatttttgg tgaccaagga gttgggcttc 27960 tcattttaaa accatgcatg agatttttcc ctttctaccc attactaaaa tatcgtatta 28020 gtgtgaaaaa ttataccagg actgggagaa aaagaaatca catctgtcct tgacaatggg 28080 ctgaatgaag aggtgaagga gtggttttac tatctaagtg actgaaaaat aggttatggt 28140 gccccagcaa atccttgttg tttgctgaca attagtgatg tctgtttaaa tcatgcagtt 28200 ttattaggcc ttaaaaatat cttttagtta gtttcaattt catcaaggga aaaggagagc 28260 agagtagagt ggaactctgc tcagagtccg gttggaagcc ttcaactttg ttctccctgt 28320 tttcagatga gtgtctattt gtggctctac cttttctctt tcttctctta ccatgacact 28380 cccctcttct ctcttatctt agctgttctt ttcttcttcc gcatattagg cagtgggaga 28440 aacaccctaa atcagttgga ggtgaggaaa gaagaaaagc acccctatct tggtagttcc 28500 tcattcttcc cttcgtcacg tccatgtcat caggctctgc cttcatctgc gatctggata 28560 caatccaatt tatagcatcc attcaaccaa aaaatattga gctcttacta tgtcaaagta 28620 gtgttctgga tgctcggctc catcagtaaa caacctagac taacatcttg ccgttgttta 28680 catctcgtgg tgtagagttt acaccttgtg gtctagaatt tacatcttgt ggtggaggca 28740 ggcagatgat taacaataaa cttaagtagg tctagatgtc aaaaggtggt aaatgctaca 28800 ggaaagagca aaggtcgagc caggtaaggc agattggctg tgtgggtgtg gaggaagggt 28860 gcaagagtac tgtcaagata agccttcctg agaacatctg aaccaggaca tgaaggacat 28920 gaggaagtga gacagtcgct atccagggaa ggaatttcca ggcagaagaa agagccagtg 28980 ttacgcctta aggtgggagc atttctgcga gactggagaa tcactggagt ccattgtact 29040 tggagcccag caagggagaa aagattggag gactcaggag gtgctggggc aggtgaactg 29100 ctttttgatt ggggagttca gagggtaatg ctttggataa atgtaactga aaactttctc 29160 agaagtgttt tcatactatc tctacaattc attttcatgt gaaaacttaa ttggcgagca 29220 gattaatatg gtgatcttcc cttagatcac taggaaaatc ttgttttatg aatttttctt 29280 cccttttcat tcactagcag agaaaagagt tgtaaaggag ccgcagaaaa ttatagtagg 29340 tttctcccta ctactgagct actgagactg gaagatgctc acgttagcaa ctgagtatat 29400 ttatgtattt ccctttaatg tttgaagggt caggaatatt tgacttagga tactagtctg 29460 tttagaaaca tgattcaact agctacatga ctaaactagc agctgtcaga gagaatgcaa 29520 ggtcaaaact tagtagttga taataataaa gaaagggcag agtgttatga aatgttatga 29580 tctgggtaat ccattggctc actttttttt gtcagcctaa ggttacaaga tgataaatta 29640 agttgctaat attctatatc taccatttac ttttccttta tcatgtgtct ggcaatatgc 29700 tgagtgttct acctctagca ttttattcaa actgtgcaat ctgcctgctg aaacaagtat 29760 cattaacttc atttcctaag gtgagaaaat tgaggcccag agaggttaaa taagtttagg 29820 atcatatgca tagctggtaa gtactatact ttaatatccc tttgccttca tgctttgctc 29880 tcactccatg tttaaatgag cagagagact tatctttaaa cagatatata gcaagtagta 29940 ttttccaaat gaattccaca agatgctcca ttgcaaaagt tcaaataagt ttagaaaaat 30000 gctgcaaact ttgtgcttct taagagattt acagtgcaga ttagcacatt aaagcctttg 30060 ggaaatttgt attagaaaaa cctttattaa cttatttacc ccaatttttc caagcttttt 30120 gatcacgaaa ctctttaaaa aacaacaagt ataattgctt ttatagtatt ctttgggata 30180 cacttggaga agtgttacat gaaaagatat gattggataa atttaaatat aggaagaatt 30240 atttaatcat tttttggaat aaaacaccaa ttttaggttg tctaacatac atttgagcca 30300 agacatgaag gacatgagga cataatttac ttttgtcctt gtaaggacat aatgcacttt 30360 tagtggtttg cattgtttat tttcttttga atttcatgtt actttataaa ggtaattatt 30420 taatcaaacc atttgttaag tgtcagacac tatggtaggt gctggtaata taaagagaat 30480 atgtaaacat caacacaaca tatctcctag tatgggctta cagtacagtg agagacacaa 30540 acaaataatt tgtaggattg aaataagtct tacatttgcc acatcaataa agcactatgg 30600 aaacaaaggc acaagaactt aactttgtcc aatgaagtct ttcaggagga ggtgatattg 30660 gagctgaatt ttaaaggatt catagatgtt tatctgaagg actaatgcaa catgttggag 30720 gtgagtcttc aggaaagagg caacaagaac catttgggta acaagatagg acttggcaag 30780 ttaggggagt cgtaagtggt tcattacggc tagaatccag ggctctctgg agagattggg 30840 agtacacaga tcactcaagg gtttggtatg aactgtcagg ctactaagac agaaataaca 30900 aaaatcagat gtgggtttag aaagagcatt ttggctgtaa tacagaacat gatggataat 30960 tgatggagcg agattcctgg ggagatagaa gaggataggg ccatgtaagt acatctgctg 31020 gtattttaaa attagaaaaa gaaatttttg gtagcaaaat cagaacagac ccaccaactc 31080 tttgcaaatc atgggactag aatgtttgga aaggaagatg ctaacgattt tcattcattt 31140 gtttatcatc tatgttgagt gtcttcttgg gcctaggcag catgcccaaa gctgggagaa 31200 taagatactg tatgagatgc tagaaagatc cccacctctc ctttccagaa attcagtata 31260 tcagactaat tggtttacag ttgtgaccat gggcttttgg catagctgtt caacaagatt 31320 tcattctttt tcaaaagcaa ttcattcatc caccaaatat ttgttaaaca aatgtacgtt 31380 gcattgtagt gggtcctcag ggagctggat gtacatgcca aatatgtttc attttatttg 31440 aagcaagtcc acagacaagt aaactagtca agtgatacca ggcaaagtga tttgctttcc 31500 aacagatggt gacagattaa tttcctaaga gactgatctg ccccagaggc actgggaaag 31560 tcttgttagg gaggtagatt atagtcagga ccttggaaaa ttgttgggaa taattgaggt 31620 caggaagggt atacttaggt ggatggggac agcccctgaa cgagggatca gtccttttgg 31680 agtgagcacg gaatattcag gtgcctggga ggagtgaagg cttgtgcttc agcactgatt 31740 gtgtgcaccg atggtggaac atacctgcct gctcagaagc tttggcttct ctctgtaggt 31800 gagagacagc cattagaagt ccttgaacag ggaagaaaca cggtgaaagc aaggatttca 31860 ttgagaagtc cctcatggaa gaagaagatt acattggaaa gagcctggct tagggaggga 31920 gcagtgacaa tcagagaaaa aggcagatag gggcaaagat actggaagaa gaggaaaaac 31980 tgtccaaagc tttgtccttg tgtgggaaag ctggtgctgt tggcgtgaaa gaggaagcaa 32040 gaacatgtgc actgacacgg ctgagagtct ccaaaaccat tgtctttcct taaaacagta 32100 atgatcacaa gcagcttaca actttgcata tagccactgg ggcaaaatcc tattaaaagc 32160 taattcatta tctgagccag tgcatgataa tgcgatgtaa aggcgtgttg ggaggcagat 32220 gatcagaact tttaagcaaa ctaaatttca taacatttat tagaagcctg tctctatttc 32280 cagaaaacgc ctataaatgt ggctgtaatg taggctacag gtcatcacac tgaagtagaa 32340 gcaatgtaca atacctgaaa ggttagagaa gttcagggtc tgggcttata aaaaacttca 32400 ttattcattt gaaagatatt gttttgtatc ccccaattgt ggttttcaat gtatataaaa 32460 gcaggatatc atactttttg atctatggat ttggaagggg ataatggtgt ggtgggcact 32520 gagcatatgg aattatttaa ttagagagat gccctttaga ttactataaa atataaccag 32580 aatctcctgt ttagacttct aaaatctact tctttgaaaa cactactaaa atgaccacaa 32640 agacctgtcc tcacaagtgg gagctattaa tcaatagtgt gtacacatgg acatagagag 32700 cagaataata aacactggag actctgaggg gtgggagggg aagagggagg tgagggatga 32760 gaaattactt gatgggtaca atctacacta ttctggtgat tgatttctct ctgtttcctc 32820 ttcagaaact gagaggaaat ttagtttcct cagtcaccac tcctccaaac tcctgcgtgg 32880 gtgatacaag acttgctgtc atcttgaggc agaaggggtt aggggatttc cccattgaac 32940 ctgatagcct tcatttcatt tctgtcttct cagggaaaca tttacccctc tttactaaat 33000 ggaagaaggt ttgtaaacta ggagggtatc tatggatctg attgctcctt caccactctg 33060 ctatatatcc atgtaacaaa acagcgcttg tggccggata cagtggctca cacctgtaat 33120 cccagcactt tgggaggccg aggtggtcgg atcacctgag gtcaggagtt cgagaccagt 33180 ctggccaata cggtgaaacc ctgtctctac taaaaataca aaaattagct gggcgtggtg 33240 gagcattcct gtaatcctta gctactcggg aggctgaggc aggagaatcg cttgaacccg 33300 ggaggccgag gttgcagtga gccgagatca tgccactgca ctccagcctg ggtgacagag 33360 caagactcca tcgtgggaaa acaaacaaac aaaagaacag tgctggtacc ccctaaatct 33420 ataaaatttt ctaaaaaata aaatgacaat aaaggaatga aaaaggcata ggtacaagca 33480 gatgggatag gacactaaag caagctggag taatactgga attctagaag gtagaaggct 33540 tagcagagca gttcaggtgg aacccacgcc tgtgggggca ggggcatgag cagtgagccc 33600 atctaactac gggaccccag ataggcttgg gatctagaag cgacagatgc ctctaaaggc 33660 tgggggtagg ctgggactga aagcagaatt ggtgtaaagt ctttaaaagg agcaattaga 33720 tccacaaata ccttcctagt ttctaattat tctaccgctt aggagagagg ggtaaatgac 33780 tccctgaaaa cagagaaatg aagtgaaggc tatcatgtta aatggggaca acacctagcc 33840 cctccttcct caagactgac aggaaagctc ctacaaccca cgaaggagtt tggaggggtg 33900 ttgtctgagg aaactaataa gtccaagaga aagaaccttc agaaacggac atttaaagga 33960 ttaggtcccc acccgattac cctagagata cacatacaga aatgtgattg gacagtcaag 34020 gatcaccgta tgatgcttct aacctgaaca atagacacct agtcacacac ccaaacaatc 34080 acacacacac atacacacac acacacacac acttacttca cttctgctgg aggaatttac 34140 aagatgaaga acatcttgta tctcttttgg gctactgttt gtgaaaggaa tggttgcatg 34200 tgctcttggc taagccaact ccatcctgaa gacagatttt tgtgaggtgg gggaaattcg 34260 cccagcgtta atagtgttag tggttgtcct gggtccatcc tggtctgtat tcctgctttt 34320 tcattttcag atttaaatcc agagttatta cagatggtaa catctgatgc caatttatgg 34380 atctttttca taattcacct gctaggaatc tcaggtaacc tataaaatat gcttttattt 34440 ggtcatttta agagttacgt ttctgaattt caggtatttt atcctgtatt gtcagcacat 34500 taaattaggg aacacattca ttgacattct atgtattttc ctttgtattt caaagtcaga 34560 gtcaagtatt taaaaagata agatctttca ttttgtgtgt gatcccacgg aatactttct 34620 actgtagatt tattaaaatt ctcccacctc tggcctctga ttaaggaatt gcagagtatt 34680 ctctatgaca actcattaaa cctattattc cccccagggc ggtttagtat atcactaaat 34740 atacttttag tgatatttgt tgattggagc atagcttttg tgtttgccaa acatcattga 34800 tgtgttttga ggtcatgtgg ttgtgggggg cagggggtgg ttgtaaatgt aatagtgtcc 34860 ctctagtatt gtaatacttc aaggacatag aatttatttt ttaaagtctt aaatcttttt 34920 gtttgttttt ctaggaaatc ttgagtctat gttctttgat ttgagactat agagtttctt 34980 ggtaaagtct ccaattattg gttttctgag taaattcttg agaattggtg aggctcccag 35040 gattattgtt tgtcatcctg ttctaattaa tagagaaaaa gcatataaat cttagatgtc 35100 ttagatctgg gactattgca tctacttggc ttgagccaaa gtgtcatcta atttttatcc 35160 agtaattgtg gcaacatatt gcttccaaaa caaatcacat ttgtaaatgc atattgagca 35220 ttttctacat gaagggcatt accagggagt gaaagaaata taaggtctga attttgtcct 35280 ctgggagaga acattctagt gggagagatg agttgtgaaa agttaaataa caaatattta 35340 tagatggtca atataggaac ttgcaaatat tattaagatt aattacatgt gaaaaattgt 35400 tattgaattc aaggcaaaag aagtgaactt aaactgagtt gcacaggaag aactcataaa 35460 aaggtgagct tgtgttggat gagtggattt gggcagataa agaaagacag gagcaaaaat 35520 aaagaggtgg aaaaccacag gggtgtttga tgtatgcagg gcacggaaat cagttgtatg 35580 gtggggggta ccttcaactt aaaacctctg taccagttag ggtgcttgag ttgtaagaag 35640 ccgaaaccaa ttctggctca tttaggcgga gaaagaattt acaatccatg actaggatat 35700 atccctccat ctatttaatc cctgtttaac ttttctttat tttttatagt ttgtatagtt 35760 ttctatgcag aagacttgca catctttcgt tacatttgtt cataagtatt tgacactttt 35820 atgttattat taaagatttt cttttttttt ttttgagacg gagtctcact ctgtcgccca 35880 ggctggagtg cagtggcgca atctcggctc actgcaagct ccgcctgccg ggttcacacc 35940 attctcctgc ctcagcctcc cgagtagctg ggactacagg cgcctgccac cacttccggc 36000 taatttttgt gtgtgtgttt ttagtagaga cggggtttca ccgtattagc caggatggtc 36060 ttgatctcct gatttcgtga tccaaccgcc tcggcctccc aaagtgctgg gattacaggc 36120 gcaagccaca gcgcccggtc aagagtttta aaaaaatttc agtttctaac tgttgacact 36180 acatagaaat acaatagatt tttgcatatt gtccatgtat ctgccaaact tgctaattta 36240 acttattaat tataataatt ttatctatgg attcttttgg attttccaaa tatacaacat 36300 gccatatatg agtagtgaca tttttatttc ttcttcctag ctccgtaact ttattctatt 36360 ttcttgacct actgcattga ctaggatcct tcactacaat gggaagaaaa agtgatggtg 36420 ggcattcttt tctcactcct gatcgcaggg cagcatttaa cttttcacca ttatgaatga 36480 tgtttgctct acagatttct gtagaaccat ttatcagatt caggtagtta atcctaactt 36540 ggctaacagc aattaaaaaa atgaagtaat ataaaaatta agaaattaat atgctgctaa 36600 tgatatgttg ttgagtaaca taaatatacc aatttttcta tatctactga gatgatcata 36660 tgaatattgt tctttattta ctatggtgaa ttgcattcat taattttctt ttcttttttt 36720 ttttgagaca gagtcttgct ctgtcaccca ggctggagtg cagtggtgca gtctgagttc 36780 actgtaacct tcacctcctg ggtccaagtg attctcctgc ctcagtctcc cgagtagctg 36840 ggattatagg tgtgcaccat cacgcccggc taatttttat atttttagta gagatggggt 36900 ttccccatgt tggccaggct gatcttgaac tcctgacgtc aagtgatctg cctgtctcgg 36960 cctcccaaag tgctgggatt acaggtgtga gccactatgc ctggctggat tcattaattt 37020 tcaaatgcat tttaaaattt ctgaactaaa tccaacttga ttataatata ctatcttttt 37080 ttaagggaaa agtagatgaa tcagactcag caaaaatagg agccagaata gcaactgata 37140 cggtttgtct atattcccac ccaaatctca tcttgaattg taatctccat aacccccact 37200 tgtctaggga gagatctggt gggaggtgat gggatcatgg tggcagtttc cctcttgctg 37260 ttctcgtgat agtgaattct catgagatct gatagtttta taagggcctc ttcccccttc 37320 gctactcact ctgtctctca cctgccacca tgtaagacgt gccttggcta ctcctttgcc 37380 atctgccata attatctgag atctccccag ccatttggaa ctgtgagtca gttaaacctc 37440 ttttctttat aaattaccca gtctcaggca gttcttcata gcagcgtgaa aattaactaa 37500 tacagcaacc atggcagggg aaggccaagc accttgactg agtatatcca atgggagagg 37560 agattttttt ctcacagcca aatcaggaca ctcacagctt tgtgtttaaa agcttgggct 37620 ctggactcag gctgcctggt ttgaagtgcc agtcctccct cttatgtggc aggggacctt 37680 agctctgagt atccttctct ataaaggagg atgatgttct atttacccaa taagattcta 37740 aggattaaat gatacattaa agtgcacagg tcagatcact ctcagcccat agaagtaatt 37800 ataattccag ctattattat tgttatttgt gaatatgaga aagaagaaag ttcactctga 37860 catcctgtaa atggaaaatt caactgaaca ttgaaaaatg tttaaatctg tctatcagaa 37920 agtttttcat caaaagaaaa cactgagtag tctagtgttg tagcttgatc caaaaccttg 37980 aataattttc aaactcattt atgatatctg aaatattcaa tgacttatac ctttgaattt 38040 tttggcagct ttgtggaggt atagctgaca tataagaaac tgcagatatt caaaatgtac 38100 agttttataa gttttgatgt atgtatacaa ccattaaacc actaccacaa taacataagg 38160 aacatacctg ccccccatcc acacatttga tgcgcctcct tttaaaattc tctttcctac 38220 cctccacccc tcactgttta ccaaaaagaa tgtctgatgg tgccctgggc agtcccactc 38280 tgcctagaaa acaccataga aaaagacagc aaaagtgctt tctcactctg gagttctact 38340 tgattttaat ggacatagat tagtgtgaac cacataaacc agtactaaaa tacaggattt 38400 gatctagaaa aggtgatgct aaaaatgcat gtagataaaa cctaattttt ttcagacacc 38460 aaaatgaaaa attattagta tgccatgaca catgaacact tttatattcc acaaccactg 38520 tgctctcctt ttggtgttca tttgcaatgg atggaatgtt tatgtccctt ccaaatttgt 38580 atgttgaaat gctaactctc aagatgatgg tattaggagg agaggctgtt gagaggtgat 38640 taggccatga gggtggaacc ctcaagaaaa ggattagtgc cctcagcaaa gaggcctagg 38700 agagctagct tgctcttccc agcatttagg gacacagcaa gagggtgccg tctgtgaact 38760 agaaagcagg ccctcaccag ataccaaatt tgccaatgcc ttggccttgg acttcccagc 38820 ctccagaacc atgagaagta aatttctgtt gtttataagc cacctagtct atagtgtgtt 38880 ttgttttagc aggctgaatg gactaaggca ttatttattg tgagttctat tcaccatgga 38940 gcatatgtgg cctatgtgtc cctggcactg aggcaggaac tgagcagagt acgcagggga 39000 attaataatg cttggaccta tctttaaaac acctagagtt tagtaggaat caactggaag 39060 tagtagggta aaggaaagta ggtgactttt gttgagccct gccatgtgct agagactgtg 39120 ctaaagtgat ttacccacat tatcttattt gaacctcatg gcaagcctgt gtggtaggtc 39180 ctattcctct atttacagat ggggaaactg aagctcagag acattaagta atttgcccaa 39240 ggttatagaa ttatcagcaa caaagctgaa agtggcaaag ggctctttct agtcaggagg 39300 aattaagaga gcttgggtgc agtggctcac atctgtaatc ctagcatttt gggaggccaa 39360 ggtgggagga tcagttgagc ccaggagttt gagatcagcc tgggcaacat agtgagactt 39420 cgtctgtaca gaaaaaaaga aaaaagaaaa aaagagcttg ggatcgtgcc tcctgtgact 39480 cagcatcacc ttagtcttgg tctgcctcca ttctgaattg tgccctaaag ctagtcattg 39540 cttccttctt ggtttctgct acaagtttct gcctctccca ctggcccatt tccggggttc 39600 ctgttcctgt tatgcacatc aatccctaga tttctgaggt cccagagggt gggcttctgc 39660 ttagtccctg tttgtcttcc cagggctagg catcctggtc cttagccctg gcactggggc 39720 ttctctccct gctgccttcg accccccggg gctgaccatc tgctgctcta tccctgcatc 39780 ctgccagctt tcacatcccc tgtctcgagc tctgcttgcc ctttactctt gaggggaact 39840 ccctgcctcc acctgttgga ctggtctggt cccttcactg gtcctgccct ttctgaccat 39900 cttctactct ggtctggcct cccattttcc agagctcatc tgtctccatg tgtgtcctgc 39960 ttctcagagg gtcttgagtt ccagcttttc caggtctggc tggtgccatg gccaaaacct 40020 gtcccacctc tcccattcga gttcctcact agctcctttt tgacagttct ttcttttttg 40080 gggtctagct ttggccttgc tgcatgaatc attaacacat aaatatgtgt cttcacaatt 40140 aattgtttcc atttggtgtt tgctctagtc aaggaggatg gagagggagc aacatcttgt 40200 actgaatgtc ttgacatcac taggaactag actgcttgtg cttcccgggc atgctgaggt 40260 ctcaagaata aagagtatcc ctgaagacat tcttatcagt cttccctggt gaaacattca 40320 tcctaatttt tccttttagc tttgagacca cttttgcatg atttttaata tgtcattaaa 40380 ttaaatagat ataattttct ctgtctagcc aagctgctgt tagaagaatc tttgcataca 40440 actaatcata aaaaagacat tcttcttgcc tctttggaaa ggagcctgtg tcacctaaga 40500 gtgaggagta cactcattct tttgtgcctt gttcatctgc tcaggggatt attgattagc 40560 agatagaatg tgggtgcagg ctggacgcag tggccatgtc tgtaatccag cactttggga 40620 ggccgagatg ggtggattac ttgaggtcag gagtttgaga ccagcttgtc caacatatag 40680 tgaaaccccc gtgtctacta aaaatataaa attagctggg cgtggtggtg catgcctgta 40740 gtcccagcta cttgggaagc tgaggcagga gaatcgcttg aactccggag gtggaggttg 40800 cagtgagctg agatcgcgcc actgtacacc agcctaggtg acacagtgag actccatctc 40860 tcaagaaaaa aaaaaaagaa atgtgggggc agataagttt tttggggggt ttgcttttaa 40920 ttctttggaa gaactgggct tggctggctg ggcacctaga gcaatgtgga catgggcagc 40980 tgcttgtccc atggatgcca gggacagagt cacaagagag acggttagaa atggtgccag 41040 gttctcgctg cctcgtgcca ggtcagctcc caacaaagcc tttgtacaag acacatataa 41100 accctcagag agtttatgct aacccagtgt cttggccatg gcttactcat gatggaaaac 41160 tgatcatatt ttattctggc cacatggaat aatagacatg taatcactat gagatttgag 41220 ttgcagggtc tttggtttct aataaccttt ataattttct ccctcatcag ggagacagaa 41280 taaggtgttt acattactac tttcattttg caagaataag atcgaggtta aatctacagt 41340 tatgtcttga tagactgcag cagatttctg catcagtaga aagtgctgtt ttcccactaa 41400 tcagaagaag aaagtgctag ccataatgat atgggtccac tgtgaagtag aagacaagaa 41460 acagagcagg acgtggaatt gggagcaatg agaaaaggtg cctagagttg ctcttggcac 41520 cctgcacctt agatcaccct tattaactgc ctgctgttta ctctgaaaat ctttctgtca 41580 tttttgagag ataaaatctg aaaatgcagt ttcttcaagt tagaaatgat aatttttata 41640 atagagttta agaaagccat gcttcttttc tcttctatga gaacattttt atttcaatta 41700 taaaattgcc actataaata gccagtcaag ttcatagggc atgagtctca tcaggcggat 41760 aatttacatt atataaaaaa agtatgagtt atttaactaa actaaaaaag caaccagtat 41820 cttgtggtca catactgtat gtgatccctt ttacttgcaa ggtaaaaagt ggtttcataa 41880 ccttgccaat ataattccaa agaactaagg acttagtgat cgttgctaat tgaagttatt 41940 ctgtttatga gcaagcaaca ctatttcttt gatgaaaacc agaaaggatt tacgtgtcgg 42000 taaatagggt tcctttatgt ttgtgtatgt gtgtgtgttt gtgtgtgtgt gtgtgtgtgt 42060 gtgattttat gaggtttgtc tcattcttct atgctagtga gtgttgatta gttggattgc 42120 cttttcagtt gacctattgc tttttaagag catttttgga tatagtccct taacccagaa 42180 ttaacttcta tgataaaaac gctttttggg ttgtcagaga ggctaatagg ggatatatgg 42240 gcagggagtt ttttaccagc cgtcagatct catcttgcag actgtaacta ctgtaaccat 42300 gccccatgaa gggtagtaca aatcatgcta ttgaaattga gagagatggc tgccttttgg 42360 acaggaagag aactagaagt ttttgacttt gtgaatctaa cctctgcagc tgcatccccc 42420 agggctgctg tccacatacc ctgtgctcca ctccctctca tgatttctct caccaccgtc 42480 attctttgtt tctcttgttc ctttatcctg aagctctcaa cctatgaacc tgtgaaaagc 42540 ccagataaca gtaacagatt acatttattt atggaacatt tattatagat ggtgtcattt 42600 tctaagtact ttaaccatat tgattccttt aatctttgca atcatgcagt gaaacaggtg 42660 attctcatac tcccatttta cagttgagga aactgaggca ctgaggggtg aaatgacttg 42720 tctgggacca cacagtacgt agtcgagcta gtatttggac ccagactgtc taactcaaga 42780 gcccaagtta ttggccacca tactctatag cacctctaac ccagatcaaa tatacacagc 42840 accatcacat agtgaaatta atcagtgtca tgtccattcc ctctgcttaa ttgtatgttt 42900 cttgtgatga ggaacataag ccatctccaa tgcctggggc cacacatagc agatgcccta 42960 taactatcat cattgtcatc gtcattctta tcttcctctt cctcctcatc ataatctact 43020 acatataagg caaatttgtg ggtcaggcac acttcacata aattagattt aattctcaca 43080 acaatcttac gaaatttgtg ttgtccccag tttatagttg aaaagacctt gcatttagga 43140 agtggtaaaa tgggaatttg cgaccctgcc atttggttcc agaatccttc ctcctaacca 43200 ctctatacca tatgcttaat taagaaaaaa agaaacaaat aggtgagaaa aaacaatgat 43260 gtgaagaatt ttgctgcccc cagtattagg attttttttc ttcttcttgc tagactctag 43320 agggcccaga tcctgtggag ctgtctctct gaagggaagg gtcaggctgt tcaccctgat 43380 tttcctggag tcacagataa acttctgccc tccaccggat gcctctatct tacacaatta 43440 ttttccttta caaatttggt tgatgacata ttcacttggg ataattgggt tgtccctcct 43500 actttgaaac tgtgagagag ttcactcaat ttccaactgc gtatgaagct cttgagtcag 43560 atttttttgc ctgtaacacc tcagctcaca ccagtgcaga aatggaagtt ttaattggct 43620 gtaggattga agggttggtt tggtgcatgg tggtatttta agaaaggcaa agttttattt 43680 aaatgaggaa tattctccct gggttttttg agttagctac tgggccatgc aacaggcctg 43740 gctgcttgtg agaaaatgag aagggtgatc aagtacaaga agatgcagcc aaagaagtgg 43800 acacaatcca cgtcaagttc catcttcttt gtggcagcca tgattctgaa ggtcactgaa 43860 gggtattttt ccctgagctg tttttggagc ctgtgccact ggcttcaaat gctgggtctt 43920 ggccacctca gttgctataa aatatggtta tgagtgcttc cgcttcccag catctagctg 43980 acaaagcccc acttgtgcct tgctcagccc cacttcattg ctcctgccct ctctggggag 44040 agggactcac cacctgggtg acaaggttag ggcttcttgc tgcacttttt ggcatcttgc 44100 tgctccctgt ataagggcaa agctaacctt ttttttttct tttcattgag acagtctctc 44160 tctgtcaccc aggctggagt gcagtggtgc gatctaggct cactgcagcc tctgcctcct 44220 gggttcaagt gattctcctg cctcagcctc ccgagtagct gggattacag gcttgaacca 44280 ccatgccagg ctaatttttg tattttagta gagatggggt ttcatcatgt tggccaggct 44340 agtctggaac tcctgacctc aaggaatctg cctgcctcgg ccttccaaag tgctggcatt 44400 actggcatga aacaccaccc cacctccaac cttcaaaaga tttaaaaaaa tgtgaaaact 44460 gaaatgaaga ctagatacta atgaaacatt ggactcatta tgactttgtt aagtcatttt 44520 gattttatta aaatcaaaca ttaataaagc agactgtgaa taaataaatt atattctttg 44580 gccatttctt cattagacaa ggatgctatc tttcatggct gtgttattgt ggggatggct 44640 gatagctcat agaaccaatc taacatccac agattttttt catagttctg gactaggttt 44700 cttagcataa tgcgttgttg tggtcctcat ggtctgttgt tctctcttgc caaccttgtt 44760 tcatcagtcc cctgttgtcc tgcagatttt tgaagcattg gaatcctagc aacagatttc 44820 tcatttaagt aggatggtcc tgatcactag tctcccacag agagttggta aaaagttttg 44880 ttcttcttat cacccacaga acttccctga aacatttttt gttgtgcttg ctcagaaacc 44940 ataagcttag tagaaaaatg caccttgctt gtgaatacac aatcaggtgt ccaaatgaga 45000 tggtcccctc ctagaagata atatttcgga agtcttgcct cagtgggagg tacttggttg 45060 tttgtttttg tttttttttt catttcaata gctttagggg tacaagtggc ttttggttac 45120 atgcatgaat tgtatagtgc tgaagtctgg gattttagtt tacccatcac tcgagtagtg 45180 tactctgtac ccagggtcct tggattttat gggcttgttt ttgtttgctt ttatgttaag 45240 atatgaataa tatgatatgc tttggctctg tgtccccact caagtcttat ctcgaattgt 45300 aatccccata atctccacac gtcaagggag gtacctggtg ggaggtgatt ggatcatggg 45360 gggcaattcc cccatgctgt tgtcataata gtgagtgagt tatcatgacg tctgatgttt 45420 ttataagtgt ttgaccattc caccttcaca cgctgtcact ctcacctgcc gccatgtaag 45480 acatgcctct tccccttctg ccataattgt aagtttcctg aggccacccc agccatgtgg 45540 aactgttgag tcaattaaac ctctttcctt tataaattac ccagtctcgg gtatttcttt 45600 atagcagtgt gaaaacagac tagcatataa tagaaggctc tttacctttt taaacttgga 45660 aggccaaatt aatactgtcc tttccattat aagaatcttc agattaaata ttttctcatt 45720 cattgtccct cagatcatat acatttgctt tttaactcta agttacatgt aataaacaat 45780 gaaattgtat tgtggatcat aaacttgagt tttaaaaaga tttttctcct aattttaaaa 45840 gtaataaaaa caataaatac ttactgtatt ccaggtagtg tttttttttt tttttgagat 45900 ggagtttcac tctgtagccc aagctgtagt gtggtggcgt gatcttggct cactgcaacc 45960 tccacttccc ggcctcaagc aattctcctg cctcagcctc cttggtagct gggactacag 46020 gcacaagcca ccaagcctgg ctaattgttt tgtactttag tctctactaa acagggtttc 46080 cccatgttgc ccagggtggt ctcgaactcc tgagctcagg tgatccaccc accttggcct 46140 cctaaagtgc tggtattaca ggcgtgagcc accgcgcctg gcccaggtag tgttctaagg 46200 ggcatgcttc cattaattca tggaattcac aataaccctt tgttgcagta actattatta 46260 tccccacttt acagatagga aagcggtaca gtgactgggg cagagagagg ctctgtgact 46320 ttgtgcaagc agcaatgtag gcatttgaat ttcggcacgc tggctcctga gtccattcta 46380 ctaaaaattg tgctgtattt aatgcagaga atttcaaaaa catgagataa aaaataagag 46440 aagaatagca tcaattttcc catcattcaa aggtatctgt taaaaggaaa catttaaaac 46500 ttagctatat atactttctg aatttgtatg tacatataaa cttataaaaa atgaaaatgc 46560 taattgtttt cacacgtact gtttggtagc ctccctttgg tatgttccca gaccaaaaat 46620 tattattctt ccccatgctt tttttcagct acataatgtt ctattttatg gaagtacatc 46680 atttccataa ttgaatttct tattaagaca tattatttgc aaatctgcaa caaatgtgca 46740 tgttattttt agacgtatgt ttggttattt ctttacgata gagtcctaga atcaccggct 46800 gaggcaaggg agatgcacat ttgaagcctc tttattcatc ttgccaattg tcctcaagaa 46860 acattgtttc aagtcccatt aatgcaagca atgaacaaaa gtttttattt ttctggatac 46920 tggatgcctc tggcttattt ttctttctat tctgtttctt taatagacaa aacaaaagaa 46980 aaagtttctc atatcaatgt gcattttttt gcgatttgca aaaagttcaa aaattaacaa 47040 aatttatcta ttccttgagt aaatgtatgt ggttcaagat gtcaaagaaa caaagtattg 47100 tgcagtggaa aatgagtgca ccttcagcac ctgcctccca gacatccatc agtaaccctc 47160 tcaggaggcg accactgtta ccatttcctt gactagcctt cctagaataa ttatgcatat 47220 acaagcaaag aagggtataa gggtacacac acaaataagc atactacata tattgttttt 47280 gcccttgtgt ttttcaccta acaatatatt ttggaaatta ttccatatta ataatcaaat 47340 aatgatatta ttatttttga tgcctaccta ctattgcatt ataagggaat tataagggaa 47400 gggttgcaaa tattaacatc tgttaattag ctttggatat ttcttctttt gcaaatactt 47460 gccagtgttc tttgagcagt cttagaattg tggttttaat gttttgttat tgatgatgat 47520 ttgtaagtct ttgctgtgaa ataagatgac cgaccattgg tattaaatga tgtaaatttt 47580 atttcacatt tcattgttgt cttttcaatt ttgttttctg gtggtaggct tattttgttg 47640 ttgtttgttt tgttttggtg tggctatgga agtctttttg ggcaatcaaa tctatcaatc 47700 attttgattt gatttgtgaa tgattttcct ggattttcct ggatgatcag aggctagtgt 47760 tgtctctttg tttacttaga ttcttttgac aagggctttg gctattgtga atagtgctag 47820 tatgaacatg gatgtgcaaa tatctcttcg agaccctgct ttcaattatt ttgggtatat 47880 gtccagaagt ggaattgttg gatcatatgg tagttctatt tttaaatttc tcggaaactg 47940 ccatactctt tctcataaca gctgcaccat ttcacaatcc caccaacagt gcacaaggat 48000 tccaatttct ccacaccctc accaatgctc gctatttttt gggtgttatt tttgacagta 48060 gcccatccta ataggcatga ggatcaattg ttctgaacat aacatttctg tcagggtttt 48120 taaaaagttt ccaaaatgac atccctccag ctccacatat tctataagag caatatcata 48180 aattagaagc tgtctatgaa aacttgtagt tggaagatgt ttgttttctg tgggttagtt 48240 acatttcaca tatgcctcat ttgtgaaata atttctaatg tgcatgagct ggaattcaat 48300 gcctgtagtc aaagtaggct taattttgaa ttggagttga ttaaaatgaa atgactaatt 48360 agctttatat tgacttggga gttgtcccct aaggaaggca ttgggacaat gttgatactc 48420 tgattacctc tattcctacc tctgttagct taaaatatta gtactgcatt cagcacccag 48480 caagaatttc tagtatctga aggcagcagg atacttgcag ccattttcaa accatggaat 48540 atggatgatt ggtagagact tctctatctt gagtcccttc taatatttca tgctttatct 48600 tattcataag aaggggcttc actaagtagg actgtcttgt cttgaccact aggggatcaa 48660 ggttaagttt cttagtcttg gtaattgtca gatttctagt ctttaaaata gggataatgt 48720 catggagtac ctatgtcaga gttgcaagga ccaaacgagc taaggcatga aaagcattta 48780 gcaaggtccc tggcaagtaa gggctaaata aacatggtgt ttcttgatgt tatgtcttgt 48840 aaccattgta ataatctcag tcaatcagat ttatatcagg gtacaggttc ttttctgggg 48900 aatttttcta gcaccaggta ttttctgttt atcttctatg tggatggctt ttccttattt 48960 cttctcattg acaccaaggg attccaagtc ccattctgat tgtgtattgt caaagtgaaa 49020 aacagctgtg gccagcagag ccatgactat aaccattttc aaagtcctgt gtgtaacaaa 49080 cctcaaggat tgatttttca ctaagccttt ctccttgact gtcaaatgac aagcaagggt 49140 atgcagatga taaccccgaa cccctttgat cccatttcca aaatatggcc atgccataga 49200 tgaaggcaaa ttgttttatt tcatcttgtt ggccccattg tgtatgctct aagttcattt 49260 tggacttctg tctttactga tagcaatttc tatttctttc agacagaagc cccttctttc 49320 atacctttta gttgcatttc ttagcattct ggccgcagtc ttctactaca tggtccttat 49380 ttgtcatctc ttccctttct tcctctctcc atcccttttt tccattattc atccagcaat 49440 atttattgag aaccaaccat gtgaggggca gcacactgga cattgtcttg gcttcctctg 49500 tcactgcaga tttaatggat cactttagac ttatgcctgt attattgcca gggttcccct 49560 atgtatattg aaacaaatag tctctgggga tctttccatt ttctgccact gattttttct 49620 ttcttttctt tttttttgag atagagtctt actagctctg tcacccagcc tggagtgcag 49680 tggtgcgacc tctgctcact gcaacctatg cttcctgggt tcaagtgatt cttttgcctc 49740 agcctcctga gtagctggga ttacaggagc gcaccaccat gcctggctaa tttttttttt 49800 tttttttttt ttgtattttt agtatataca ggtttttctc atggtggcca ggctggtctc 49860 aaactcctga cctcaagtga tctacctgcc tcggcctccc aaagtgctgg gattacaggc 49920 gtgagccacc acacctggcc attttctgtc tcttctgatt gggctgtgta tctgagctgt 49980 gtcctgggcc actgtgccat cccacagctg acaaaatggc tctcacctcc aggaaactct 50040 tacctcagca ttttttcctc tgtcttgagc ttttcttttg ttctctggga atagtcctct 50100 tactttcttg gagcttcttt agttattttt tgatcaattt tttttacaca gttttttgta 50160 acggagcaaa atattttcag aacttgtttc tggcatgtgt gtgtctgtct catctatctg 50220 cctgtgtcta tgttaaccgt tctttgaatc tgatgcccaa tattctattt gattctgttg 50280 attctgaaaa tttcttttta gtcattggtt tagcatttct acctcttctc cttaaaccct 50340 aggattttct ttaaaaagtg ttgggactga tgttctgttc ttcagattgg cgaacatggc 50400 tcaaagacca ctagtgttta agcagcagca gcttttctat attctgcttg ctgtgggcac 50460 ttgtgatgtc ccactgtggc tgccatcagc agagatgtgg atcctggtgg tggctgtgtc 50520 tgcctcctgg ccagccagct tcctttatag ggaagaaatg cttccgcttc ttactggggt 50580 gtgagaggcg ggcccgtcag tcactgctgc tccctagcac tcatagcaat gtccattttc 50640 tatcctttgt gccctgatga taatctttct ggtatcataa ctgtcttctc ctccccttcc 50700 ctgtctcctc ttcctgcttt ttttcttctt cctccttctc ctcctcactc cagtatcaag 50760 gcttagctta aatgtgttgc actataaagg cctcatattt taaaaatata attcattcag 50820 tcctcctcta tgcctaagct tatttctttg ttatggcact tttcatttca tagtatagct 50880 ctctaccgag gagcgcatac gggataaggg cagagtatga gtattttttg agcccaaaaa 50940 ataatagtca tttttattgg tatagcttca agcatagttc atttacatga tttatgtttt 51000 aggaaatttc aagtgcagaa aaattgccca gcagttagag atgattgggt tatcaatatg 51060 ctccctgttt tttggtgtat tttttccagc tttattgagg tataacttac aaataacatt 51120 gtatatgttt aagatgtaca acttgatttt ttcaaaatta attatttttt tgaagtaaat 51180 tttattgtgt atacttaagg tgtacaacat gacgtgatga gatatatata gataataaaa 51240 tgattactac agtgaggcaa actaacgtat ccatcatctc acgttgttat ccaacactaa 51300 aatctacgca tggagcaaaa atgcggaata cagtacaata tgattaacta tagttctcat 51360 gttgtagatt aaatctctag acttgttcat cctatatctg ctactttata gcctttgatc 51420 tacatcttct cattttcttc ccttccccca accctcccca taaccactgt gttatgttct 51480 atttccgtat atttgactta ataaaagatt ccatatataa atgagatgat gcaatttttt 51540 tctgagtctt tgtttatttc acttagcaca ataacctcca ccaggctcat ccatgttgtg 51600 gcaaatggca agatctcatt cgtttttaag gctgaataat attccatttg tccatttgtc 51660 catgaattgt cacttaggtt gtttccatat cttggctgct gtgaatagtg ctgcaatgaa 51720 cacgggggtg cagatatctt tacgaggtgg tgatttcatt cctttggata tatattcaga 51780 agagggtttt ctggatcaca gagtaattct attcttaatt ttttgagaaa atttcatact 51840 gttttccgta atggctgcag caatctacac tgccaccaac agggtacagg gttccctttt 51900 ctccacacgc tcaccaacac ttgctatttc ttgtcttttt ggtaatagaa gggcagggca 51960 tcattaatat tgtttccctt acatgtgctg aacaaacaca gcagagcagt taccagcgct 52020 aactctggaa ctggcttgct catgctcatc tcttgtccct gccagttcct aactgcggaa 52080 acttgggcaa gttgcttaac ctctctgtgc cttcctttgt tacttggagc tgataaaaat 52140 aatgcttaga acagttactg ccatataaaa agtgctatta agtgtttgct attatgtgtt 52200 gaattcagct taatagaatc atcatcagga tcaccagcaa tttattgagt gacagtgtgt 52260 gttttattca ttgatcgtca ttacacttag aatagggtcg gggatatagc aggcattcaa 52320 tcaatatttt tgagggaatg aattaatgaa tgggctagat gttatatata caaagaaata 52380 tgtctaattt ctttccttca ggtctcacag atggttgaga atacaagatg gagataagac 52440 gaaaattgaa tggtgcttaa tatgaagccc ttcaaggctg cctctttcag aatcatttag 52500 gaggcttatt aaaattgcag atttgctagc caaactctcc tcgatctcag ttccatagat 52560 ctggacgtcg gtccaaaact ctacagtgcc aagaaagctc cccaggggct tccggtgaat 52620 tcccaagaac agccaggact gggatcgcag gccaggcagt aaatgataca ggagatgaga 52680 ggagggagag ctctgggggc tgacactgtt gggaaggcct ggtgggaggg gaggtacctg 52740 caagggcatg tagggcttgg gcatggggtg gacttgatcg tgggggctta gactgcagta 52800 gagacattct ggtcacattt gcctgcccat gagctccttc cgtctcctga tgtgcctcag 52860 caatttcatg tgcaaagtac acaagagcca tttgttggaa agtacctaaa tcactctatt 52920 tactgagtgc tttacttgca cttataaatc taaaacaaat tttcaagcaa ataaacaagt 52980 gtgtggatat ggagcagaaa taccactcat ggcatcctga acttggccct ctgactcagt 53040 aattagtatc ctaaaactga gttcaagcat cacattttat tttcaggttt tacatacttc 53100 atagaacttg gtctctgatg ttacagagat cacagtaaca gtttacctta tctccagaat 53160 ttctaacttc tcaatggtgg catctctcat tagaacaggt agtcaccaaa tagttccaca 53220 caaagactct cccaatgtgt catttattaa aacaaacaaa cagatttgat atacaattaa 53280 tataccacaa aatcacccat ctaaaatgta cagtctggta gtttttaaca tattcagaat 53340 tctgcagctt tcaccacgaa ttaatcgtag agtattttca tcaccccaga gccacccctc 53400 cctaccttta gtcacttccc atttccccgg cccctgataa tcactcatct gctttctgtc 53460 tctgtggagt actattctgg aaatttcata taaatggaat gatacaacat gtggcctttt 53520 gtgactgact tcttttactt agcatactgt tttcgaggtt catctatatt gcagcatgtg 53580 tcagcacctc atttcttttt gtgctgaaca ctattctact atataaatat acttcatttt 53640 ctttatccac tcattagctt gtacacaact ggatttccac tttttggcta tgtgcaaagt 53700 ttctgtatgc atgcatgttc tcatttctct tgggtaccca cttaggactg gaattcctgg 53760 gacatgtgct aactgtattt atctaacttt ttgagaaatc ttcaaaatgg ttcccaaagc 53820 agctgcacta ttttatatgc ctaccagcaa tgcatgaggg ttcaatttct ccacatcctc 53880 accgacattt gttattgtct ttgattatag ccatcccagt gtgtgtgaag tagtatcttg 53940 ttatagtttt gatttgcatt tccctaatga taaatgacat aaagcatctt ttcaggcata 54000 ttggccattt gcatatcttc cttgagaaaa tgtatgttca atttttttcc atttaaaaat 54060 ttgatgattt taaattttat tgttgagttg taaggattcg ttatatattc tggatagtag 54120 acccttatca aatatatgat ttgtaaatat tttctcccat tttgtgaatc ttttcacttt 54180 cttgatagtg tccttggatg cacaaaagtt tttagttgtg ttgaaaaaca gtttgtatat 54240 cttttccttt ggttacttgt gctttatgtg catatctaag aaactgtttc taatcctggg 54300 tcaggagact tacaactctg ttttcctcta agagttttat agtttcagct cttatattta 54360 ggtctgattc atttagaatt aatgacttgt atatggtgtg aggtagaggt tcaaatctat 54420 tcttctgcat gtggctatcc agttgtccga gcactaaatg tttagtccat tttcatcctt 54480 ccattttgtc ttgtccaggc tgttgaagta gcctcctcac agctctccct gctcttagct 54540 cttctccacc agagtccatc tcccaccata ctaccagtta ttcatcttat acacagatat 54600 gattatgtcc tttccttaat aaaaaaactt tattctttcc ttagtttcta taaaatagtt 54660 caaatattca acataaaatt ccaggtccta tctagcatga cctcaaccca cctcctaatt 54720 ttactgtgtt ccttctcccc acttgctacc ccatcccagc catccttgac ttcttagctg 54780 gtctctttct ggcctgagtg agacatttgg cctggatata tatgcatggt atggctttgg 54840 ttgcttactg tggcattggt gcttatggga tagccattga ctttaattaa tggggtgtta 54900 tcagcacatt tatcctattg aaatgactag aggaacccat aagaaaccac attttcagga 54960 ctagtaatct attttagcat catttggaag acaacaaact ttcattttat gggtagacta 55020 acattcacaa attatgacat atatcatata atcataatca ttaagttata ttttaaataa 55080 tcaaccatcc accatcccaa actctaagac tttgttggta agttttgtat gtcacaggtt 55140 catatttttc acattctgac acctacattc aaggcctcaa actttaccag agacttttta 55200 tcattgaggt aaaactagaa gtcattaatt taaaaaatta tattattttt aattatggta 55260 aaaacataaa atatacattt taccatcttg attttttaaa gcagtttact agtgttaagt 55320 atattcaaca gatctccaga gcttttcatc ttgtaaaact gaaactgtaa cccatttacc 55380 aacaactcct tccccatttc cttctcctcc caaggcctgg caaccaccat tattctttct 55440 gtttctgtga attttactac tttagatacc tcatataaat ggagtcatat ggtatttagc 55500 acaaggtcct caaggttcat ccatgttgca gcacatgaca gggttttctt ccttttcagg 55560 gctgaataat actccatttt gtctctatat cacatttttt tgtttatcca ttgatctgtt 55620 ggtagacatt tgtgttgctt ccacttcttg gctgttgtaa ataatgctgc tgtgaacaca 55680 ggtgtgcaaa tctctttgag gactctgctt tcagttcttt gggatatata cacagaagtg 55740 tatataggat taggattgca ggatcagatg ataattattg ttttaatttt tcaacttatc 55800 ttctcgaatg agaacactaa attaaatttg tggggtttgt gtcattttag acatagctca 55860 cgaagaagat ggtaacttta aattgtccct gcaacaatga tgatgggctt cagtgattgt 55920 cttaaatgag tcatcattat ttttgtgttt tataaccaac cctatgcatc tgaacacaaa 55980 agtcaaacct ttttaatacc tcaggtgtat tttacaccaa aatacaggga aaaggcatca 56040 atcaaagctg cttaacagct gatatgatag tgattacatg tgatatggta gttgagactg 56100 aaatgctatt tgtaatacaa agattatctt aactgagtct gatttgaggt gaaaaaaggt 56160 actaattagg gtgacaatat gaatttgatt taactttaaa gtattatgag agaaaacata 56220 ctatgtcaca actcttttat ataacgaact gggatttagg tatggagtgg gtagaatagt 56280 ggtcaagagc agggattctg gagtcaagtg tttggcacca atcctggctc tggccattgc 56340 cagctgcatg agtgccactg ggcaagcttc tcacagcacc agatttttca tctgtaaaat 56400 acggttaata atggattgtg gtggcattac atgaattaat atacgcaaca tgccggaatg 56460 acatctggca gggaggaaaa gccatataag attttgtaat tgattttcta gcacaagcta 56520 tccattctta ggttgttgta tcttccttgt gtcatcccac atatcaatat tgtcatctgc 56580 aaaaaatata cacgtatgtc tcttttaact aatgatttta aaatgtggac taatcaatga 56640 tctaaaatcc cccttccttt tagtcaatta gtagttcata aattgaagat gtgatggata 56700 gaacatttcg tacccagaaa gctcttagat tgtgaatgct gagggaacac tgggagattc 56760 agtgagtgca gcacaaatac aatctaggtg actggaatag tttctaatga atgaatcact 56820 gaataagcag atgggttgtg gaaggcaaac catgagtaaa ttttttcttt tactacagaa 56880 atatttctga aaggtaaata cccaggttta tgatgataga ccttctttaa actcatgcta 56940 tttttctttc tgggttttgt tgtcaacaca atctcatctg ctctttgcaa ccattacctc 57000 tcagaatggg tatgaagatc aggtgcaacc atgtatgtga taatgcttct aaaaactatt 57060 ttttttccag ttttattgaa atatattttg cataaaaata taaaatccac ccatttaaag 57120 tacaaagctc agtggttttc agtacattca cagagttgtg cgatcattgc cacaattaat 57180 tcctttctgt ctccatggaa tctaattttg aacattttat ataaatagaa caatacaata 57240 tgcggtcttt tgcgtctggc ttatttcatt tagtatagtg ttttcaaggg tcatttatat 57300 tgcagcatgt atcagtactt cattcttttt attgccaaat aagacttcat tgtatggata 57360 tgtactacat tttattttct cattcatgag ttgatgaaca tttgggtttc cacttttggc 57420 tattacaaat aaaattgcta tgaacgtttg tgtgtgagtt tttgtgtgga cacacatctt 57480 taattctctt gagtatatgc ctaatagaga aatttctgag tcatatggta accctatatt 57540 tagcacttcc aggaactgcc aaatggctgt acgattttac attccaacca gcaatgtgtg 57600 agggctccaa tttccctaca ctgtcatgta cacttgctat tatctgtttt gtcataatgg 57660 gtatgaagtg gtaaaactac tgaaaaaagt gacatattca tggagtaaaa gtaaaattga 57720 aacatgcaga aagtattctt caggcccaga cagcccccca gaattacagt tttttttcta 57780 gagtccttga aagttgtcta tgcacatatg acgtatccct agatatgtat ttgcaagaac 57840 acatgtagga gtatactatt ttgtatcatt ctttatcact taataatata cctaagagca 57900 attgctatag aacaggttga cctgcctcat tctttttact cttagcagag tattttttgt 57960 gacgatgtac cttcgttcgt tttaacagct tttctaatga agggcatttt ggttggtttt 58020 gctcttataa gtaatgccat gcgcatccac aagacataca attgttcttg agtacatttg 58080 tgaagatatt cacaggaaaa aacaagttat actgctatat accaccatca acaggggatg 58140 agagtgccta ttagcccaca atctttccag cttaacactg tgtgttatca gcctttccca 58200 tcttggccaa tgtggtaggt aaaaaatagt tcagtaaaag ttgatttgac ctataagggg 58260 caaatcaagt ttatgttata aagcttgaag ttcaacattg aagttgaact ccagataata 58320 tggttaaagc tttcaaattt ctgagaaata tgcaggcata gagattgtat ctaaatttgc 58380 cttaatacat agtatatcca tttgctaatt gaagaaggtg attggttcat ttatttattc 58440 aactggcatt tattcagcat ttatcgtatg ctaggtgaac tttaagtgct agagagaagg 58500 atgaataaga aacatacatt gcttacaagt aatatatagt ctaataaggg ggacatatat 58560 atataaatca ataagcataa tggacatgaa atagaggcaa gtattataca ataagctgtg 58620 tatattaggc cataggctaa gctactgtga aaaaaaagga ccctcaaata cttgggaaat 58680 tgcttttggg aaaagacaaa aaaaaaaaaa aaagcttgtg gaaaagggtg aaaagtggac 58740 atgagagtaa ggagagtaag ccatttttaa aataaaattt tattttaact tcgattgtca 58800 tatggtaagt gtacatattc atgggataaa aatgaaaggt tttgacacat gtgtgcattg 58860 tgtaatgatg aaatcagagt aattagcaaa tccatcatct caaacattta tcatttcttt 58920 gtggtaaagc attcaaaatc ctctcttcta gttagtttga aatatacgat gcattattgt 58980 tagccacagt caccctgctg tgcaatggaa caccagaact gattcctctc acctaactgc 59040 aactttgtac cagttgatca acctctcccc atagccattt cctcttaagc aagaaacatg 59100 gaaattgtac acattacttc tgaaaataca ctggcaagcc acttctagtt gcagggtaga 59160 cttggaaaat gaagtctaac tgggtgaccc tgtgcctcca cattattctg gaggaagggg 59220 atcacggagc tagggtcccc agtctgggag gctggtagag aggcagctcg ctgtgctact 59280 ctgatatttt tagctccgtg ggggaaaaag aactgctaga cagagctctg tcaacacaga 59340 tctgacaatc tcattcagaa acaagttaca gagacctcaa gtgattaata aacaagatta 59400 ttctatagaa catcttatgg tgacataatc aatatgattt caacactcag ctaataaatg 59460 ctatgaaata caatttatgt aaggtgttaa ttgacatgtc aggttttaaa tacaaaagga 59520 atgagggagg gagacatgaa tatagatggg tgttatcaga gaatgacact tagatacatt 59580 tcatattgtg tcatgtaaac taatacctac tttttgggat atttcttcat ggtttagttt 59640 ttaatgtaga ttcaagagtt ttatatattc aaactcttca tgaaaaaaat tcagctctgg 59700 ttatgtacat ccacatttac aggaattgaa tttttctttt tgtacacttg tgagtatatt 59760 ttttcctatg gcaaacgttt tccagaaagc aaaagttatt tgtgttactg tccctgataa 59820 tcgatgctgt gtaataaatc gttctcagca atggcagttt ggacactgat ggacagttgg 59880 tgactggtaa tttgtacagt atgtttagtg ggacggcggg caagggggaa aagtggcatt 59940 tggttcctca gtcccagatt tgggtcaatg ttctcataat actggtgagc aaggagccta 60000 attctttagg aattttaaaa ggtttctttt agtgaagaac atttcccagg tgtctaatga 60060 aaaattataa atgaccaggt ataattttgc caagctttcc aacatagttt tcctttaggg 60120 tgagaaacaa tcctttgatt ttcttgaagt agaagtctct tctcgaatgc taacagtaaa 60180 acaagacctt ttcagacaga ttttgtattt tgccatcaaa tgtgcaattt ttgaagatac 60240 gggacttgag aatcaggtaa acttcgttct gaaaaccagg cttaatttta tgactgtgat 60300 tagaaagttg aaaaaaaaat cacgttctca caaatgaaaa caaaagtcag agttcaaact 60360 gtttatcctg tttctgtaag cttttgtttc agaaggccaa ggattatttg aggagaacct 60420 ggaaaattaa ctcaaatgga ggaaaaaaat ggcgtttatg caaaatgcag caaaagcaga 60480 cagccttgga gaactgaagc ttaaatagcg taagagtctg agtactagtc ttcagatact 60540 taaaacagca tttgatagac aagttagata tttaaggaaa catttaatca gcttggcatc 60600 agcattagtg gcttcaattt ttggctgagc ctgactttgc catatgatcc tagacaaatt 60660 tgcctaaaat gggtgatatt aacttcttta gggaaaggct ctgtactggg atttttttga 60720 ggcctatgat ttatggggtc aagctataaa acaggaggaa acacatgctc atttgtataa 60780 tttttacata tatttggtcc ataattgtac agctaggcaa ttcatttatt atctgtttga 60840 gagtaaaagt ttgattattt taatgttact acttctggtt ttttctcttc tcacatgttc 60900 ccagtgactc ctttctgata acccaactta tcatcataga acgcatgtaa tgctgagaat 60960 aagacacagg gtcttggaaa atgaatgaca gcaatggtgc tccgatggca gttttgtcag 61020 actttgaatg gtttatgaaa tcactgttga taaaagtgaa caccttctac tgaagggaga 61080 aatttagggg ggaaaaatcc caaatagaag gagttaatat ccaaacctgg agacttacct 61140 ggtaaggttc acttaactgg taaaatgtga tccaatttaa acaaagtatt tttagttttc 61200 tcagaacaaa catcctacat aaacacaaaa aatgatatga gacatagata taacttggtt 61260 cacaatattt tccaaaacta taatgtacca gccagttggt acagcacacc aggagagaag 61320 atcattatta atgtgctaat agcagcattt tattttgaaa cccactctgc atggttacag 61380 ggctcaaaac aacatattct aacaggaaga tacattaccg aaatatttta atgagaatat 61440 ttaatatgca ttgagaggtc cgcattttct tgcagagacc ttgtaggtag ctctttgaga 61500 tttctgtctc tatgcattta agtgaaggag ttggttgggt attttagttg gcaaattttg 61560 cagacatgta gctttggtag tggagaggta atagtaccat gccctgcgtg ctggcgagga 61620 agccccacag caacagtggc ttttagcagc taccagattt gctaaaagca gccatgtcca 61680 attagcagta agtgccatgc acctgcagtt actaggaatt gaacctcttt tgaggctgaa 61740 tcttaatgta gccttttaaa aaaatagcaa aaatcttact catactctga gataataaag 61800 aaaaattagc aatggcaaaa tggacgcact ctgaaatgta ttcttaataa tgatttagaa 61860 tatggggtaa atgtagaggc aatgacacat ttaaactgca ttatttttaa atactgtttt 61920 atcagtttac ttcctaattt tgaattcaat tttcatatct atactgcaac tgcttttttt 61980 tttttttttt agaaatctat aatattgctg caggctccct atgtatgttt ccataatttt 62040 ctgcaaagtg ttttcaccag aataaaaaaa aattacagtt caaaattgca aaactgtaga 62100 aaaaatatgc tctttgactt cttttctatg tgtcaaattc accacaatgg aaaggactac 62160 actatagaat taaaacgtta ttttcaacag atagtactta ttttaacatg tgttcagcat 62220 ttaaaaatat ttaatattct tttctaaaaa tgcttacatt cagaaactat ttatgagggt 62280 tctgagcagt atgatgtttc tttctctgat ttactgcttt ttctctttta gaggatattg 62340 taggagaaaa acatttgtta agcaatttcc agaactacta ggttctaata agaccaatag 62400 gctaataatt catttcattg caactggagt gtgtactttt cctttattct cagtcataat 62460 tttttaaaag agccaagaac accaaatcat caaatctaat gttgaacatg tagtaacttt 62520 tatttgctga tcatactctg agattcacca taacgaataa atcataagta ttaaaatttc 62580 agctttttaa catacccact acactgctag cctggtaaca cagtcaccaa ctacacagct 62640 tcttcaactg ttgacgtgct ttaaagctag gattatggta tcctgccaaa aagatcctac 62700 aaactgtcac tattttggtt tgtcctgcca gccattgaga agtagacaat ttctatatac 62760 acaaaccagt ttggaaaatt tatgcaaata ggaagttatt ctcaaaatgg gttatttgat 62820 tgcatttttt tttttttttt ttgagacaag gtctgactct cgcccaggct ggagtgcagt 62880 ggcgtgatct tggctcactg caacctccac ctccgtggtt caagcgattc tcctgcctca 62940 atctcctgag tagctgggaa tacaggtgca tgccaccact cctggctaat ttttgtattt 63000 ttagtagagg caaggtttca ccgtgttgac tagggtggtc tcaaactcct ggcctcaagt 63060 gatccaccca cgttggcctc ccaaagtgct gggattacag gcataagcca ccgtgcccag 63120 cctgattgtg ttttaatgta ttggctccca accagtagca acagtttggg tgcacagata 63180 ttgccgtagt gtttctattc aatgtgtcaa attatttagg taaaagtttg gcttaacttt 63240 gttgacatgg aatttctata tcctccagtt tctggtttaa ctggtttatg tggaaatgaa 63300 tggaaacaca tggttaagtt ccccagcctc cagcttctct cttcctctta cctatatttg 63360 tacttgccca cttttcctct tgtgggcctg ttcctagaat ccattatgtt ctgtgggtga 63420 catcagcctg ctactgcggg aagaaataga attttatggt gcccaagata aaatcgacta 63480 tgatgatgca gaatgaagac ctggagagga gtcagagatt gcaggggata aaaagagaga 63540 aatcagagat gctcccacaa acagagaaaa ccttcagaag cagcaggaag gacagagtaa 63600 atggagaaca aaaactcaag tcaaaatagt caatggaaat aaacagtttt gaattccagt 63660 tataatttgg aaaagaagca aacgtttatt ttaaattaag aaaaaagtcg cttataattt 63720 cctgaagttt agaaaagtga aaaatagtta aacctcctgt tgttagctaa gaagtgtcta 63780 ttattataag tttgttgctg gagagaacat aaaaatctct atctattgct attttttttt 63840 tttttgcata agggatggat aaaagagtgt ttattttatt tagcctttgg cctgtaaagt 63900 aagatttatg aaacaaagga caatcggaaa tgataagaat tttttcctaa tttctaatta 63960 tttagctaaa ccttgattga tttctctcag gctagtgccc atattacagc agcagtcagc 64020 cttcatttat cttacctggg accactgcta aatccgatgt cacttttcag tttttatatt 64080 atgtgaccat ttagccacat ttcacctact tgatcattcc ctccatcttg agacctccct 64140 cgacccggct tccaacatac tttgccctcc tggtttttct ttctctgttg gctcactttc 64200 tcagtctcct ctgctggttg ctccattttt ccacaatctc tcaaaactgg tgctcctcag 64260 attaagtcct tggacttctc tccttagatt gacatctgga gtcatggctt caaacaccac 64320 ctatcactcc ctttctcctt gaactctaga cgtgtccatc caactgctac gtgacatctc 64380 cactgggatt tctaagaact ttgccaaact taacatgtct aaaaccaaat tctgggctgg 64440 gggtggtggc tcacgcctgt aatcccagca ctttaggagg ctgaggtggg cagactactt 64500 gagcccagga gttcgagacc agtctggcca atagagaaaa gctgtctcta caaaaaatac 64560 aacacttagc tggacgtgat ggtgcatgcc tgtagtccca gttactgggg aggctgaggc 64620 gggaggattg cttgagcctg agaagttgat tctgcagtaa gctatgatta caccactaca 64680 ttccagcctg ggtgacagag tgagaccctg cctcaaaaaa aaaaaacaaa aaccaaaacc 64740 aaaaccaaaa aaaaaaagca aagagcaaaa cacaaaaaac atattccaaa tctccccttt 64800 aaacctcctc ttcttacaat gagtcctatc ttgatttatg gcagatcctt ccttccagtt 64860 ctcaagccaa acaccatggg gtcattcttg actcctctct tccatgggct catctaaaca 64920 tcagagtatc ctgttggcta tctggaattt aaccacttcc tatcactgcc attgctaccc 64980 acctgctctt agttatcacc agagttccct ggagtgttgg agccgccgca gagctggttt 65040 ccctgctcct gcctttcctg cccatgctct gtcctgccag tcagctctgt cctttaaaaa 65100 tggaaatcag gttacctcat gactcttttc tttctttttc ttttcttttt ttttttacag 65160 aatcttgctc tgtcatccag cctggagagc agtggcatga tctctactca ctgcaacttc 65220 cgcctcccag attcaagtga ttctcctgtc tcagcctctt aagtagctgg gattataggt 65280 gccagccacc atgcccagct actttttgta tttttagtag cgaaggggtt tcgccatgtt 65340 ggccaggctg gtcttgaact cctgacctca ggtgatctgc ccgcttcagc ctcccgaagt 65400 gctgggatta caggtgtgag ccaccgcgcc cagccatgac tcttttcaaa aactccccat 65460 cttctccact tccattcagt aacagtcaga tctgcatggc cccctcctga ccttctgatg 65520 tcatgttctt tgctacccct tgagtgcatt gaacatgcct ctgacccaga acttttctgt 65580 ttgctatttc ctcaagtgca tatcttgttc cttcattttc ttcaggtgat tattaaaatt 65640 tcacttccat gagtccttcc ctggccccca tatttaacac tgcatcttcc tccatcttct 65700 ttccctcctc cccatgtaca ttttactccc ttactaaatt ttttttccta tctcactttc 65760 ttttcttttt gagacagagt attactctgt cacttaggct ggagcgcagt ggcgcaatct 65820 tggctcactg caacctccac ctcctgggtt caagcaattc tcctgcctcg gcctcccgag 65880 tagctgggat tagaggcgcg tgccaccatg cctggctaat ttttgtattt ttagtagaga 65940 cagggtttca tcacgttggt cgggctggtc tccaactcct gaccttggct tcccaaagtg 66000 ctggtattac tttctaacct cctgtgtatg ctacctattt atttgtctgt ctctctacac 66060 tagaatataa gctctatgag ggtagacttc tttgttttgt ccaatgctct atttccaata 66120 tttataaccg tactggccgg taggtactgt caattatagt ttttgaataa attgagagta 66180 acaaattcta actggtgaaa ataaattaaa tgggccgggc gtgatggctc acgcctgtaa 66240 tcccagcact ttgggaggcc gaggcgggca gatcacttga ggtcaggagt tcaagaccag 66300 cctgggcaac atggtgaaac cccgtctcta ttaaaaatac aaaaattagc tgggtgtggt 66360 ggtgcatgcc tgtaatccca gctactcggg aggctgaggc acaagaatcg cttgaaccct 66420 ggaggcgaag gttgcagtga gccggcattg agccactgca ctccagcctg ggcgacagag 66480 cgagactctg tctcaaaata aataaataaa ataaaaatta aaaagaaaat aaatgatctc 66540 acaggatatc atttcttgat tggaggagga gagaaaaatg tgtatgtgtg agggtacaga 66600 gagagttcct ttgcattagt gagggttcac atcagaactg tctaacctcc ctactcagtg 66660 ggtcctgtta cctctctcct gaatccaata atactctggt gcacaccttt tactggtact 66720 gaggctattt taacgttcca ttaaaaaaaa aaagaaaaca tttaaaatac aaaaacaagg 66780 ctgtactact ttaactctga ccttagaaga ctctcagttt tataactgtt tagagaaaat 66840 gtggaaatgt ttgctggccc caatcttttt attactcatc tctataaaga ggcttttaag 66900 gacatattaa aaagtttcca tctctcttgt ctcttgcctt tcttctcatc ttcctttctt 66960 gtaccccaaa tggctgaaag caagaccctg agagtctgga agaaatatat tctggtcaga 67020 gcagactgag ctggagctgg cctagaacct tggatcctga cctcagaatt gctgctcaaa 67080 ttactgctct ctgaaagagt gagctcatgc atgtttatta ttactgtgaa caaatttagc 67140 tgttgtttca cccaaacatt gaagttctcg cttggacccc tttgcttgtt tgtgcttttg 67200 caaatgtgtt ttctcatgtg ctactagaac caagatgaaa gcttcagttc tcagaacagg 67260 tgccacgacc gaggagacaa aacaagagct atagaggggt gtggtgtgtg aaactgagaa 67320 agcaggtagt ttttcagaaa aactgagagc caggaatgac ttcatccatt tcctgtaata 67380 aggcaatggt ctgaccttga ggaacctatt agagtgtgct tctaaacaga ggccatttcg 67440 aggctgaatg tacgggagta tttacctttg actgttttct gaagcaaggt attttataaa 67500 ctgtaaagtg gcttatacaa ttttaggaat ggaaagtttt gcaaagtctc caaaatccct 67560 gggagttttg aatgtgcagg ccatatgaat tctttgtagt ttcatggtct tgctgttcag 67620 cattctttag agtcacctgc atggtagaag tttagtagga atttgggtag ttatgggctg 67680 gtttctttgt tttcccaaat agaggtagca aaatggatgc taagaagcaa attactttta 67740 ctattttaga tgcctctggg gacatcctgt cataatgcaa cttaaaatat actcgtctcc 67800 tcagttcctt tttatgtatt tatttaatag tcttcaacca atttgttctt cattagctgt 67860 tctacaatac ttcaagagaa gtcatgataa tgatgcattt aggatcagaa aaatatagca 67920 tgtgtgagtt cctggggact ttagagaata tctagcccag tctttcattt tatagaagag 67980 gaaggccagg gatggtggct catgcctgta atcccagcac tttgggaggc caaagtgggc 68040 ggatcacctg aggtcaggag ttcgagacca gcctggccaa catggtgaaa ccgcatctct 68100 actaaaacta caaaaattag gcaggcctgg tggtgggtgc ctgtaatccc agctactcag 68160 gaggctgagg caggagaatt gcttgaacca ggcagaggtt gcagtgagcc aatatcatgc 68220 cactgcactc cagcctgggc aacagagtga gactctgtct caaattaaaa aaaaaaaaaa 68280 aagaagaagg agaggaagct gggggtgagg acaggcagtg actcacccag ggtctcacac 68340 tgatttgctg gcagagttaa gcatgaaaag gtgcctctcc tagtctcttt ccagtgttct 68400 tgtcatcaca atgagttaaa ataaaaatta ctagcaactt gggagtaata acaataaact 68460 tctcaaaatc tactacatgg tctagaaaac caaacataag gccggacgca gtggctcacg 68520 cctgtaatcc cagcactttg ggaggccaag gcaggcggat caggaggtca agagatcaag 68580 acaatcctgg ccaacatggt gacactctgt ctctactaaa accacagaaa ttagctgggt 68640 gtggtggtgc gtgcctgtag tcccagctac tcaagaggct gaggcaggag aattgcttga 68700 acacgggagg cagaggttgc agtgagccga gatcatgcca ctgcactcca gcatggcgac 68760 tggactctgt ctcaaaaaaa aaaaaaaaaa aaaagaaaac caaacataaa accagaatat 68820 tcctgtgagt tccattacat aggacaatat ggtcctgctg atctattaaa attatgttta 68880 taaattagag gctcttcatt gggagatata cttaatgcta gatgacgagt tagtgggtgc 68940 agcgcaccag catggcacat gtatacatat gtaactaacc tgcacattgt gcacatgtac 69000 cctaaaactt aaagtataat aataataata ataaaaaaag aataacagga aaaataatta 69060 gaggctcttt actgtattta aggtgttcaa ataattgaag ctagtttagt atctccttag 69120 ccttccccag catgccctgc agctttgacg ctgcagaaca ccagttggtg gctgatattt 69180 agatgatgga aatcttggac acattttcat ttttgataaa atgacatggc actatggtta 69240 cattttacaa atatttttgc ggatgtatat caggtggcat acccaagaag gaacagacct 69300 tcctcagggg tccttcttag gaaagtacag ctttgcttct ctgatcatca gaattggatc 69360 cttcaggtat taggttggtg caaaagtaac tgcggttttt gccattcaaa gtaatggcac 69420 ctgaaagggt tggtaaaatt cagaatatta taaaatcagt aaaagcttaa tcaaatttgc 69480 ctaaatctat cctacagatt agtctatgca tggtttatta aacaacctaa ctgaaacaca 69540 catgcatatg tgtgagtaag ctgacatcag ggatcacctt atcatggaaa atctagggaa 69600 ggttggctca atcttcaatt tgtgaagacc aattccccta ccacgtccat atatacatat 69660 tcccaggaga cttgtttctt cagggctctc tttggttctc agctcttcct ttctgaatta 69720 gtgggtcact ttaacctccc ttgggtcaca gtcgtgttcc acactgggtg ggtccagagg 69780 tagaactcat tgcctttctt tgaatcccac acaagaccac ccaacaaggc attgtagttg 69840 gtggaaaact ccattgaaga aagggtctat attgcaacaa acaagcatct agaaatagaa 69900 tattaaatat ccctcctctt aaaaatccat tgtccaattc agacttcagc ataatgtaat 69960 cttctgtctt cttttctctg tgtttccatc ttgagagcca tcctattatc tgtgtccttt 70020 ctttgttgtc ttaggaagaa tattttggct tatcctttgt tttgttctct ccttcccgga 70080 cctattatgg taaatgtgga atttgcagat aggcttattt gcgctcccca gcctgctccc 70140 ttaatgctct ctggtaagac acttctttga gtcctccgag gcgagttgct gccccccagc 70200 acctgctctt ccccatcgca acccatgaca gtaaacgcac tgcacatact tatcccacag 70260 actgctgtga gaactagatg gaggctatgt gtgaagctgc aagctcttgg taaagtgcta 70320 cagaaattgg tagacactgt tactatgata agatgttcag aaaataatgg atcgattaaa 70380 gtttcactta tctattaaaa gataaaaaac tctatgattg agaccttttt ggaatattgg 70440 aaaatatttt tgtgtgctta ttagcatact gatatgtttc agtacacatt tcatggattt 70500 atggctaagg atgttacttt caagaaggta actatacatc gctctctact agcatgctgt 70560 tctgttcctg agaaatagtg gctgggcgaa gggtatgcaa acatttctta atatctcatc 70620 caataccatt ttcccactac taattattca acacatggaa atgtaggtca aagcattaaa 70680 aaaaaaaact agaacagcaa taccttggtg gttggcaggt gtttatttaa aatatttacg 70740 ttttagcctt attttttaat acttcttttt catatatatt agatatttaa ctaaagaaaa 70800 taataatcat tctcatggaa tactttaaaa tagtagaaac aatcatgaat agaaatgaag 70860 atttaggcct atactaccct aggctctgtc attcttattc ctaaccattt gcataggaaa 70920 tttagattca cccacttctc tttcttagaa taagattcac aggtttttgg gcatattccc 70980 attgcatgcc tgactgggga ggtgttcaaa tccctgcttt tctactcctc agccctgtga 71040 ccctgagcaa tttctgtggc ttggtttcct catctgtaaa ataggatatt aatagaacat 71100 atccctttaa cgttgcagtg atcacattaa ttagttgatg caaaacagtc catctagaac 71160 agtaagccct caataaatgc tagctatcat tatcatttca tagccagccc caccatggat 71220 gggtcatgtg acctgaagca aatttaaatt ctctggattt cagttatctc tcattgaagg 71280 aattaggctc catcagtggt tctcaaactc aagtgagtat cagaatcaca gggagggtgt 71340 gttatgacac tgaaggccgg gccccaccct cagaatttct tattcagtag atccaggagg 71400 gagtgcaata atttgtattt ctaaaaagct cccaagtgaa gttgatggct gatctggaga 71460 cacaccttga aattcttctg cttactctaa acaaaacgtg cttttttatc ttgagtgcac 71520 atcagaaccc tctggggagg ttaaaagtcc cagtgaaatc acaacctctg cagatggtaa 71580 ccagatctta gtggctttta aagttctcca ggtgcttcca ttgagcagct aaggttgaca 71640 acacttctaa caccgctttc aggtgaaaaa gaactatcat tctaacttaa atgaaggaga 71700 aaatgaattc atcattctga caccgttatc tattctttca tgcatgggct tatcctatga 71760 gaaataaaca tttactaagg tgtatgcatg tttttagaac atccattggg aagcatgttg 71820 tacagcttgt agtaaaacag catggtgcat gctgaaactg ttataggctt tgcaagttat 71880 tttttataaa ttagttttgc tggtgtgctg tttgattatt ggagagtggt gtgaacatgt 71940 ttctatgcat cccagggggt tgctgtcacc tttaaggggc ctctttaaat cccagctctt 72000 tcatttacaa attctatgac cttggatgag tttcttcact tttctgtgcc acaagttctc 72060 agtaaaatgg agataattat agaacttact tcatagagct ttgagaatca tacaggtaaa 72120 gttattttac gtaattagca ctcaaaagtg accattaata atctaacgtt ttaaaatata 72180 ttaataggcc agatgcagtg gctcacacct gtaatttcag cactttggga ggctgaagtg 72240 ggtggatcac ttgaggtcag gggttcaaag ccagcctggc caacatggcg aaactccgtc 72300 cctactaaaa ctgtaaaaat tagctgggca tagtggcgtg tgtctgtagt cccagctatt 72360 caggaggctg aggcaggaaa atcgcagtga gccgagatca cgccactgca ctctagcctg 72420 ggtgacagag tgggactcca tctcaaaaac aaacaaacaa acaaaaatta atagtttaaa 72480 tatttttaat atatttcaat atataaagat gtaattttta ttttaaatat attaaaatag 72540 ataagtttaa aatacataaa gtaaatatat aaaattaata tgttaaaatg tttactgaaa 72600 gtttacattt ttctctgtat tgctaagagc aatttattgc cttatatgtt gtgtaatatc 72660 tagaaaacac acctatgtaa tttccaaatt ataaccacct tggctcctgg acaagtagga 72720 ctgtgtctga tttttttttt tgcatccttg tcactacctg ccactctgag atcacttgtt 72780 gtctttccat atataatcac ctctaggtac acttctttca ttatttctac gcatcctctc 72840 cactttgctg cattcttgtg tgcattcttt tctcccacgt tggaaagaaa tatgcatatt 72900 gagcgattcc aacccccaaa ggcaaaaatt actagccagt gttgaaaatg aaagcaagga 72960 attttttggt tattgttgct gtaacttttt gatgtgcgta catatgtgcg tctttttttt 73020 ccccctaggg gtggaatggg gtggtgttag tcagggatta ctgacaggac ggtgttgcct 73080 actgtgttgg agagactaag actggggaaa gattctccaa ggctgggaaa tgcagacgtc 73140 cagtcttgga aaacagtttg tcgttggtcg ttatgtcaga agaggagtgt attcctggaa 73200 gaaggcccac aaaatatacc cagagcccag gtgcctttct aagacgaatc aacattcact 73260 cacaagttca gctaatatat gacagaaata caagaatgaa caagactcct gacttaagct 73320 tacagctgat gggaaacttg ggaactggac agagaattaa aatacaacgt ggttaggtac 73380 aacttacctg cgccagagga gtgacggaag gccttggacg gggagtgatg cctggaggat 73440 gacagggcga caggtaagtt agggggctgg gaaggggaag ggcggccctg tgggtaaagg 73500 gaaggaggtt aaagtcagca gggaaacagg cagttccctg ttgctggagc aaagcgcggg 73560 ggtgtggctc tcctgtctct ggctttgctg tcaacaggcg agattggcaa gtagggcgac 73620 caaccggcct ggtttgctcg ggaccggggt ttcctggaag gtgggacttt caatgctaaa 73680 actgggacag tcctgggcaa acaaatcagt acggttggcc accctatctt tgtgtgggca 73740 tctgctaact gagtcatggg cctgtctggt ttatttattt attttttttc tgcctgagta 73800 acagaagaat gtgttaaaca tatggagtat ggaagaagaa ggagagggga gataggattt 73860 ttatgttata gattggaaga agacatcctt gatgaaggag atgtttttac tttggagaag 73920 gactgcctca gccgcgaaag accaaggggt ggcaccacag ggagaagtct gcactgcgct 73980 tgtcaggacg gccagtgggg ggctgctgag cgcagggagt cagtcctcgc aatgaagata 74040 tagtctcggg gagataatgc tggaaatcga tggaagaagt ggaacaggac acaaatttag 74100 tggaatttct ttacaatgtg tgcttcttgt caccagttcg ttaaccatga taaaaacggt 74160 tatgttgtta cattcatcaa gatccaaatt ttctaccatt ttaagatgtc tatcagtcac 74220 aatgatgatc actgaagacc gaacgagatc atttcctcta aaaattatgt tacatttatc 74280 cataatggca tcagtgtctg ttacacgttt gctttaattt tgaggtcaaa tacgacattt 74340 gtaaatctag cacttcatgt gattctgtaa gcactaaaca gctaaacata tttacttctt 74400 ttttttgaat caattagaac agtgctgtac aatagaaaaa tagaacagtg ctgtacaatg 74460 gaaacagtgc tgtacaacag aaatctgtca gccacacgtg tcgtttaaac ttttctagta 74520 atcacattaa aattgtaaaa agaagccaat aaaagtaatt ttaataatat attttgtttg 74580 acataatata gctaaatatc aattttgaca tgttctaaat ataacaatta ttaatgaaaa 74640 atattacatt cttttggctt tgtactaaac atttgaaatg tggtgtacgt ttttcactta 74700 tagcacacgc aattcagatg ctacattttt attaggaata tttaatctgt agatagatat 74760 cgtaaaattt acatttgaaa aaaatagatt cagacaccta agttgttaca agcatactta 74820 aaagttttca atgactgaat tgagtatcag ttttaaaatt taaatcaatg aaattaatta 74880 aaatgaaatg aaaatttaga aactattcct cagtcacgct ggctacattt caagtgcttc 74940 atagccacat gaaagctgta ttggacagca aagaagtaga atatatttgg aataaaaatt 75000 ttaaagtgga cacattgtgt tactctcgtt agccatgcta ttgctatttt ttttcctata 75060 gctaattaaa accttaagat ccagtaggtt ctccaccttt ttttaaagca ttagttccat 75120 gtcgaccctg tagatggcag cactttcttc ctaaaactac atggaggagt tgcctgggct 75180 tgtcactcag attctggcac ttttcataga aagagtctga attatctgga aaattctttg 75240 gtaacatagg tcagaatctt ttcagctcta ttgttattct gcacagatgg ctgttgctta 75300 tgaaaacaat ctctcagcct ctagtccagg atattactca ttcctcagtt caagaaactc 75360 tagggtgaga ggagaaaggg gttcaattac agaactgtta tcaaaatgcg ttggtttatg 75420 cacatccgtg ttttggacat ggtgattcca agagactctt aataaaactt ttcaaagtag 75480 atgagagaca gtttttccct cacatgctgt ggcaatatta atctatgttt tcatgttcca 75540 ctggactttg taattgaatt ttaaggaatg catacagggc ttcatattta tatataaaat 75600 atccatatcc agtgttgaaa gaaattaaca ataaaatatg tacctgtata aaatttgtga 75660 tttttgaagc acccctctct tcctcttcgc attgcatttg tggtaggaga acatgagaca 75720 aggaacgagg tactaaggac aaagaaggag cgattcagag gtggatttcc tgaagaccaa 75780 caacattttt gcatagctcg tgaggactct ctgatactaa actccaataa atgatggttt 75840 ggtgttttga ttgcttttga ttgacattta aaaattacag gagactgaga taggaggatt 75900 gcttgagcct gggaagcgga ggttgcagtg agccaagatt gcaccactgc actccaacct 75960 gggtgatcga gtgagacccc atttcaaaac aaacaaaaaa ataaaaaata aaaaaaaaca 76020 aataaaaatc acacgcctct ttttttcact caatctgttt tccaaataaa atatcaagat 76080 tctatttgaa ttttaataat gattttgctg agttttatag cttgaatact atggcaagta 76140 taatgtctaa aatgctgtga ttttgactta agaaaaaatt tacagttttc ttaatatact 76200 ctttagttct tttaaactct aatacatgaa atggattgct aatgagggta ggaaggggga 76260 aagactgggg agaaaaatag ctaacttttc tagcgataga tacatgtcag aagctgtagt 76320 aggttctttt gcatgtgttt acttacatta ccttctgtaa tctgcattgc aattttttca 76380 tagacaagga aacctagact tagagaagta caatacctgt catctcgtaa atgacagata 76440 tagttgagca aatctactga aatggtttag cttcttatct ttccagacaa cagataagga 76500 cttattctat atgaagacat ctgagaaatg aaaatatggt ttcaggttca tagaatcttt 76560 tacaccacgt atttctggtt ctctttcttc tattcagatc attctttcat ctgtttcttt 76620 tgtcttcttt tccaaaatgt agcaattgcc ccaaattcag tacttgtctc tcttcttaac 76680 aatcacatcc aatcccatgg cctcaaccat cttcccttgc atataatttc cacatttaca 76740 actttattct cttgattact caggataaga taattgctga acaaataaca gcatatatct 76800 cagcttaaga gagtaaaagt ttatttttct ctcatgcaaa ttctattgca gatattcccc 76860 acctccttcc ctaggttgtc ctcaaaatgc agtgactcag ggaactcctc tttctgtctt 76920 aacctatttt aggtcttaga cccctttggc agtctggtga agccaataaa tctcctctca 76980 ggacagtttc taaatgtgat aaaagaaaaa aaagatatag tgacagatct aataattaaa 77040 attcaaagtt aatttcaaat tagtgatagg taaatatatt tcaagatgtc tgcactgaat 77100 acagcgtgat aggtaatata tatgatttat cttggtgaca aagacattgg tattgctaac 77160 actattatag ctgccatctg tattcacaaa gggagatgtc aaattccagt taaaagaaag 77220 attttcttaa cccaagttca taggacttcc tgaatggtac agatgctaag gtctagtggc 77280 tccacaacta ccaaagcctt cttagtgttc tctgctggat cttatgcatc caattgactg 77340 acaagcaaag aacctgcaga ataataggag acatttgttg ggtggggaga gcaaacctag 77400 aaggggcata taccccttac aattatagct ctatgcgcta gaattagtta tatcattcct 77460 cctagatatg aggggactag gcactgtact tcagctgtgt gtccaggaaa aaggtaaggt 77520 atggggaatg tggagcaata attatttgaa gcaagaatca ccagtggatg ctaaaattcg 77580 tgagggaaaa caggaccaga aacaggatat ttttaaagtc tccaagtacc tccacatagg 77640 atacttatta attgcaaagg gaaaatagta actttacaga gaagaagaaa tctggcagac 77700 actaccatat ccaagtgatc aaaggtgaca tcagtagtgg gacacattaa catcatgtgc 77760 ttctgatatg atacacaaag gagaaacaac ctcattcttg tgatgttcct gccaaaaatc 77820 cataacctga aagaagcatc acaaaatccc caattgaggg gcattccaca aaatagctgg 77880 ctagaactct tcaaaattgt caaggtcatg aacagttcca gaccaaagga ggctaaaaga 77940 gacaggatgc ctcaatgcaa gtataatcct gaattgggtc ttgggtcaga aaatgggcat 78000 tagtaagaca attggcaaaa tttgaataag gtcaatagat ttgaaaataa tactgtacct 78060 atgtgaattt cctgactttg atcaaagcac tggggttaag ttaaaacata agatgttgtt 78120 tttggaaata catgctgcta tatgcaactt actctcaaac atctcagaaa aaaaaataga 78180 taagttcata gatagataga tgacaggata ataaagcaag tgtgataaaa tgttagcatt 78240 tggggaatgt aggtaaaagt atatgggaat attttgtacc attttctcaa cctttccttt 78300 aactcgtaaa ttacttaaaa gaaaagcaat aaccctggct cttataaaac taaggaaaat 78360 ggtccatcct ttcctgtgcc ttgtgttttc ctgctggtca aagaaccttt ggtaatgaca 78420 atctgagttg gtcactgata ttctagtaaa ttcagaatat aacttcctgg gctatgtaga 78480 aaaatatagc tcttcatatt ttaattcatt ttcctgacag cacgtttctg tgcttttatg 78540 tatggatact gcctagtaat gtgcacacca gtcctgcaga tcctggaaca ttttattatc 78600 ttgatattga cttacgtatt taggtagatc tgaatagcag aattgtcagt cgtttcacca 78660 agacattatc gggaaatctg gacttggaag tctacttctg ccaggcatct ctccacgctg 78720 gcttctgggc cacagaagaa aagatctaat caaactcatt tattaacaaa ggcttataat 78780 attgaatagc agcttccagg aatctaagaa aatgttcact tttatttctg actaaggagg 78840 aactattata gtctttttat accagttaga agtgatgact tggtattaaa cttattctaa 78900 ttctcaatag ccctgatctc gactctgacc acatgcgcgc acaccctccc ccaaccctgt 78960 aagtgtgatt atggcaaggg gaaagttaaa gtggagtgaa tggtgagtcg tggaatgaca 79020 gagagcattt agcatttgta attgacagag ttggtgattg actgaatgga cactgaatat 79080 ctaggctaaa agtaattgaa tgtggatggt gtagtgagat ggagaacact agcaggaaga 79140 tagactgggc tacgcagggg ctagatcatg tgttcagtct gggatatact aagtttgagg 79200 tttctgtaaa atgtccatgt gaagatgtcc aattgggagt tggatattta tttatgtttc 79260 cattcccatc aatcgataag cttcagagga aataagagtg taagattttt ttgaacaaca 79320 ggaaaggaag attgtagtaa gatatgatgg cataatggta tatggaagag ttttaaataa 79380 aagttagcca ggcatggtgg cacgcgtctg cagtcccggc tactcgggaa actgaggcag 79440 gagaatcgct tgaatccggg aggtgaaggt tgcagtgagc caagatcgca ccactgcatt 79500 ccggcctggg cgacagagtg agactccatc tcaaaaaaaa aaaaaaaggg atgaagaggg 79560 atgaggagaa ctcaagttat attagcctga atggaataga tgagtggaga gatgggcatg 79620 ataggtgagt taagaaggaa attctttgcc tcagcaacca actcagatgc tttgtgaatc 79680 taaattatgt gttgacattc tagtagacct agacctggga taattcactt cagcattatg 79740 taatcttaat ttttcattta taaataagaa aatattatgc aatacttgcc atagttttct 79800 aaaagctgaa ctcagaatgt taatgaaatt aaaatgggaa agctattttg cttagaagat 79860 attttgttat aaacatttct taaatgaaga ggctctagaa atatttattt tatagaattt 79920 aaaatatagc catcactaat aaaggcaggc ataattccaa cgatttcata acacatcagt 79980 tattaaatct aattaatata taaatgtaac taatatgtaa tttaatataa ccctaattca 80040 atgtttaacc aactgaagct ggttaaacta tgaagaagaa tcttcaaatt gaccatttct 80100 ttccaagcgg taaaggtgat acgggatttt gtctatacat atagagcaaa ggagaattaa 80160 gccaagattt agaattttag gcaaaaagtg tttatagtat cattaagtgg ttacatatgt 80220 aattttactg ttataaatat gactgagtca attttttttt caaagatttt gtcacaatgg 80280 gaggcacaag gagtttagac agatgaagac tctttctaga aatctaccta atctatcaca 80340 ttagacctgg agataattgg tttgacaatt tcagttgttt ctcagcaaaa aaaataagaa 80400 actaaaagtg ttcagatggc agagaaaaaa gtttgaagag gagagaaaga agaacaaaaa 80460 gaaaaaggaa acagtagaca tataaagaaa gcacctaaac cagtgagatg ccccagctat 80520 gcaccagcag catggtggat tacagtagag tttttctaca gaactattgt aaatcactgg 80580 aaaatagtgt ccaacttatt tgcttaaaat tttcagttaa tgtgctccag cagcattctg 80640 tagacaacga ctctcactct ccccttatta tggaggcaga gctgtttctc tttgtcccgt 80700 tctctagcct gtgatatact ttttattgct caagagctat agaattgtat ccatgcctat 80760 tgttgtcctc ctgatgggaa ttcatgtaat tgaaagcgtt tatcctctct tagtagaaaa 80820 attgggcact tggaggcaat gaaaatcccc cacctttgtc cacggcactg gaaatactct 80880 tcagtctgct ttgttctaaa gtttctactt ttcccagtat aacctgttga aaatttagtc 80940 cttcatgaga aatacggctg gaatttcttg tggcaggctg gccgccggtg ttcatgtagt 81000 tacacctttt gttgctattt caccactgat caaaaaataa aattgtattt tttcaaaaga 81060 aacatggaat gacatgaaga aagtccttaa tatatcatgg agtgaaaaac agcaagttgc 81120 catgcaaatg tcaaatagat cctatatttt taaataagca actgcatatg tatcatttaa 81180 atatatatgt ttagatattt gctaaattat gaaccgcagt tacccctggg gagtgaggtt 81240 aggaaaagta aagtgagatt ttcacttttt acattatact ttttacttta cccacttctg 81300 tattgtttga atctttaaaa tgaacaagtg ttattttgta attaaaaaaa acaacaactg 81360 acaaataact atggggagta agaaattact tggaatggaa tatgtttaaa taattaattt 81420 gttgatacac tgcttgacta ttattttctt ttgctaaatc aaaactcccc tgcttttctc 81480 aggaggttgt tttgaaaaga agggtaaatg tttctaatga aatgaacagc tcaaccttcc 81540 cacctcctgc ctaaatgcct cattttggtt ttgttactaa caaatgcaac acgcaaggct 81600 ttatggtaaa gcaagcaatg tgggtttcta acagggcagt acacacccgt agttgctggg 81660 aaaccacttt agtaatggtg gatttattga attggaacag gaatggagat ttggaacaac 81720 aggaagtgag gtacctgtag gggtctcagt tgtcctgggc actgtgacat ggcacccaaa 81780 tgtcatgcaa gagtggccct tccaacatat gcaccaatct gaatctctcc aaagtttctt 81840 gattacacca taaaacaatg aagagaacag cattgccaat aacttcagta ataacttttg 81900 catcatatta caaagggtgg tgggtggcac tttgtgtggt catgggtatg tccaaaagaa 81960 gggagtggtg gctagactca gttctccttt agattttaag gcaaaattta gcaaactcta 82020 tggcagattc ttcaactatt tgtcagacag acattgtcta cttttctggg gatttatgat 82080 tgaggcccct tttgagggga gctttgagtg cagtgaggcc agatagaagg gccaagaagg 82140 atgggagcag ctgcatgcta gtgagcaatt caaagttgga ttgtgctgac tggaaaatcc 82200 cggttagcaa atcaactatc acagacttca tattcttttc agatgtgcag cctttataac 82260 atatttgtaa atgctaaagg actgctccac agggaggtta caaagagaaa agctctgggt 82320 ggttgtaaaa tggacaaatt gtaaagcctt actagtagtc ttaccattcc tctcagctca 82380 taaaaaagtc ctcctcttca tttgactatg cctcaaatct actgcttctt ggattattaa 82440 acactctttt cctccaggat cttaaaatct ctctgttata agttgaattg tgtccccctc 82500 aaaaatgata tgttgaggtc ttaaacccca gtatcctaga atgtggcctt atttggaggt 82560 ggggtcttta cagggttaat ggaattaaaa caaggccact agggttggcc agtccttttt 82620 ataaggaatc cagtatgact ggtgtcctta ttaaaaggga aaatttggac agagacacac 82680 acatagggag aaagacgtga tgatgaaggc agagtggggg gtgatgcttc tataagccaa 82740 cgaaccccaa agattgccag caaaccccca gaagctacag agaagcatgc aacagatttt 82800 ctatcacagc cctcaaacag aaccaaccct gccaatgctt tgattttgga cttttagccc 82860 ctggaactgt gagacaatac atttttgatg tttaagccac ccactttgcg gtgctttgtt 82920 ccagcaacct tgggaaatga ttacactttc tcatctgtga tcacagtgag gccttgtcac 82980 aatcttcact cattccttct atagaaagct gaaagcctat ggacaaggat aattgccttg 83040 gctgacgcat atgtttgaag gcagctgctg gcaggcaacc ggagacttta ccctggtcct 83100 agtggagagg aagtctatag gaggaggcag ggagccttcc tggctggcaa cccagtgact 83160 caggttgttt tcttactcca aggatctctg tgcaagtagg aatcctgaca tcttctcttt 83220 ttcacttgtt tatgagaccc tgcttgttgt agagtaaaga gcagaactta agaatggaat 83280 ctaatcacct tgaaagaata atctctcatc tcctctggtg gcaaaggatt gggatgtgga 83340 ggttatagtt ggaaaattga ttcctaggtc aatgtctgtg ggtgaatttc tctttgaatt 83400 gttatcagca atgttatggt gttcggtggc tttcaacgaa ataaacacac ctgacatcct 83460 tagtaaagag aaagctttct gaaataagag tgagggacag actgggacat gatgctttgc 83520 atgaaatagg tgttcagtaa gtatttgtag agttggaaga agttagatta aacagggcta 83580 ttgtatggca cattgtcatt agggagttag agagggcttc tggaaaggtt tggtcagttt 83640 tgacttacct tgcaataaat ttggactata ataaccattt cactagtttg taaaaggtac 83700 tggcaaccaa agatggggaa tgccactcaa tctcacttgt tctactttca aaagcttgct 83760 ttggtcacat tgaaaggttc catttggtga agtatagcat atcacagaaa acaatggagt 83820 ttgggagttc gggaacaaat ggttgttttg tgataatgaa taactttgac atttcgtttg 83880 aagttaagtt atgttgtttg aacttttctg tccctgaaca aggcatcgta tgccaagaac 83940 aggtaacagt ttctggatca ctggggactc attagtcatg gatggttagt ggtactacat 84000 tgtggtcttc cttcaatatt gaaagctgta agaagcttgt gacaaattct taccttggcc 84060 ctcacacagt actggtaggg ctgggatgtt attgcttttg tccaccaact tccaactgta 84120 gaagtctagg atgatcacag cagttagaga tgatccattt agatagtcta tattaaggga 84180 aagtatcctt catccatggt gttgaacatt cgtaggatta aaatgaaaga agccaaaacc 84240 tttctagatc tttattggta tatcaacaga attagctgat taggtatgca gaaaaaactt 84300 gggacttgaa gacaccatta aataaataac tgtacataac catacattaa ataactgtaa 84360 caccattata taaataacta actataaata aagagctcta cattcaaact gcttttcact 84420 gcatttgtca gatttcactt ttaatataat tttagttgac ttatccctca tcttacctta 84480 agaagataat gagttgaggt ggatcttgag ccagtgttta gtccaatata gccctttgac 84540 ttggggaaag atcaaacttc gaaatttata tgcatgactc ctctctgggc aaggactgaa 84600 gtggcaggag aggtgaaaga aggaatcagg acaaaaagta gatgctaaaa ggaaaacagt 84660 ctgtcccgtg gagaggaagt acccaaagaa acagaagaac tccatgatgg agagtaatac 84720 aagttgaata tcccttatcc aaaatgcttg cgaccagatt gttttggctt tgggattatt 84780 tcagattttg gaatattttc atacccgctc agtatcccta atctgaaaat ccaaaatctg 84840 aaatgcttca gtgagcattt cctttcagtg tcatcttggc cctcaaaaag ttttggattt 84900 tggagcattt tgaattttgg atttttggat tagggatact caacctgtac tagcgtgtta 84960 aaacagtcct ggccaggcgc ggtggctgac acctgtaatc ccagcacttt gggaagccga 85020 agcgggcgga tcacaagatc agaagatcga gaccatcctg gctaacacgg tgaaaccctg 85080 tctctactaa aaatacaaaa aaattagctg tgccgtggcg ggcgcctgta gtcccagcta 85140 ctcgggaggc tgaggcagga gaatggcgtg aacccgggag gcggagcttg cagtgagccg 85200 agatcgcgcc actgcactcc agcctgggtg acaaatcgag actccgtctc aaaaaaaaaa 85260 aaaaaaatcc aaaaaaccca aaacagtcct agaggctaca gcctagagca gtgggcaaag 85320 agaagcagaa tctacagaag atattgttca aggcctgcta tgctaggtct cagatagcac 85380 cagaactggg cagggcaaga aacgtcaggc ccaggggtct ggtttaacca gaagaggtgc 85440 tgaattttag gatctgaata gcaagggttg tggtcaggaa gtcagtttca tgtaagaatg 85500 aaggtgagcg gatcttaaat ccctgaaagg aggcagagag aagaatatag gaaatgggtg 85560 gataattttt gttgcgagta aaaatgttca ggactttgga ggcaggaaga gcaggtaaag 85620 caagttcgag gaaagaggct gggtcagagg ggatctgaaa gcaggagtca gaaacatcca 85680 ttggaggcct ggagaacata aatgggaggt gaatagactg gggacatagt gcctgggtgg 85740 aaagaagctg gctcgagtcc gaaaccacag gctgaaatat taggaaaaag agacccagga 85800 attcagttca gaataggagg gatttgtggg gcaagaccag tggttcttcc agacatttta 85860 tcagagataa caaagcagag gctgtctgtt ctctgccctt ggtgtgagaa gaaaaggact 85920 gacaggagtg cttggcagct caagccagtt atggagctgt gggtgctagt ggctattaac 85980 taccagggaa ttagctctgc tgaatgagtc ctcacgcaga ggcagggata gaacgttgca 86040 ttcagaagac tggccacgga ggccggctgg ggtggctcac gcctgtaatc ccagcacttt 86100 gggagaccaa ggcaggagga tcatctgagg tcaggagttc gagatcagcc tggtcaacat 86160 ggtgaaacca tgcctctact aaaaatacaa aaattagcca ggcttggtgg cgggtgcctg 86220 taatcccaac tactttagag gatgagagag gagaatcgct tgaacccggg aggcagaggt 86280 tgcagagagc cgagatcacg ccactgcact ccagcctggg caacaaagag tgaaactccg 86340 tcttaaaaaa aaaaaaaagg aaaagaaaag aaaagaagag tggccacaga ttggcttggc 86400 tggagaaggc atttttttat agggagatat acgtgagttt gacgggatgg gctagcaggc 86460 ggacattcag gttttatggg ataggcaaaa aggtacaaat ggtatttggg gggatgtgaa 86520 tggcatctga gaaaggttga tccaggcttg tgtggaagct ggctctgagc ataaaatgcc 86580 agagaaaggc ttgtacaact ctgaggtctt ttcttttctt ttcttttctt tttttttttg 86640 agacagagtc ttgctcttgt cgcccagcct agagtgtagt agtgtgatct cggctcactg 86700 caacctctgc ctccctggtt caagcgattc tcctgcctca ccctcctgat tacctgggat 86760 tacaggcacc tgccaccaag cctggctaat tttttgtatt tttagtagag acacggtttt 86820 accatgttgc ccagggtggt cttgaattcc tgacctcaag tgatctgccc acctcagcct 86880 cccaaagtgc tgagattaca ggtgtgagcc accgcacctg gcctattttc tattttttaa 86940 ccagtcccaa gtaagggtat tggttagggt tgaggcaatg gaaatctgaa agaaagggtg 87000 agttaggtat ttcactggac acatgtggag aatgttggtg atttaatgca gagggaattg 87060 tggttaaaaa ggttaatgta agaagggtca tgtggggact ggaaatcaca atagagaaac 87120 agaggccaga atgctgaact cataggaagt gggtgaccat gggtgattaa aatgtacaat 87180 agggctgggt atagtggctc atgcctgtaa tcctagcact ttgggggact gaggcagttg 87240 gatcacctga ggtcaggagt tcgagaccag cgtggccaac atggggaaat cccaacccta 87300 ctaaaaatac aaaaattagc cgggcacggt ggtgcatgcc tgtaacccca gctacgtggg 87360 aggctgaggc aggagaatcg cttgaaccca ggaggcagag ggtgcagtga gccgagactg 87420 cgccactgca cttcagcctg gggaacaaga gcgaaactct gtctcaaaaa taaataaata 87480 aataaataaa aataaaaaat taaaatgtac aatagagtgt gtaaaaccag gaaatctaca 87540 tcttgacact taactaccca agacgcaatt ggttcctcgt ctgattttta aaagaagttt 87600 ccactttctt cggaaaatca cgacagtcct tgttctcaat ttctttgttt ttaagaagag 87660 aaatgttgta tgatttcact tatataaact acctagaata ggcaaattca cagggataga 87720 aaggtggaat ggaggtgacc aaaggtggaa aggaaggagg attgttcaat gggtacaaca 87780 tttctgtttg ggatgatgaa gaatttctgg agatggacaa tggtgatggc tgcacaacac 87840 tgggaatgtg cttaatgcca ttacttaaaa atggctaaaa atcatgcatt ttatgttatg 87900 tatatttaca actttttttt ttttttttga gacagtgtct tgctctgtca tccaggctgg 87960 atggcggtgg catgatctcg gctcattgca acctccacct cccaggttct agcaatgctc 88020 ctgcctcagc ctccccagta gctgggatta caggtgtgtg ccaccatgcc tggctaattt 88080 ttgtattttg agtagagatg gggttttgcc atgttggcca ggctggtctc gaactcctaa 88140 cctcaagtga tctgcccacc tcagcctccc aaagtgctgg gattacaggt gtgagccacc 88200 atacctgcca tatttacaac ttttaaatca taggaaagaa accactaatg ctttgacaac 88260 tgtgagattt tgaatctcaa ctgtgagatt atggtttgtg gaaatttctt tatgtgatta 88320 aaaaagatac tttttttgcc aaaaaatttg ttttcgctgt catgcaagtt ctcctgggta 88380 agcacctttg gtcttgtttt gtgcatagca tacagagcag caattgtata ttgctaaaga 88440 aagcctgttt tttttttctt gttaatttat ttaagttcct tgtagattct ggatattacc 88500 ctttgtcaga tggatggatt acaaaatttt tctcccattc tgtaggttgc ctgttcactc 88560 tgatgatagt ttcttttgct gtgcagaagc tctttagttt aattagatcc catttgtcaa 88620 ttttggcttt tgttgccatt gcttttgtgt tttagtcatg aagtctttgc ctatgcttat 88680 gtcctgaatg gtattgccta ggttttcttc tagggttttt atggttttag gtcttatgtt 88740 taaatcttta atctgtcttg agttaatttt tgtataaggt ataaggaagg ggtccagttt 88800 cagttttctg catatggcta gccagttttc ccaataccat ttattaaacg gggaatcctt 88860 tccccataag gatatgaaca gacacttttc aaaagaagac atttatgcag ccaacaaaca 88920 tatgaaaaaa acctcattat cactggtcat tagagaaatg aaaatcaaaa ccacaatgag 88980 atactatctc acactagtca gaatggttgt tattaaaaag taaaaatata acaggtactg 89040 gtgaagttgc agagaaatag gaacacatat actgttggtg ggagtgtaaa ttatttcaac 89100 cattgtggaa gacagtgtgg cgattcctca aggatctaga actagaaatg ctatttgacc 89160 cagcaatccc attactgggt atatacccaa aggattataa atcattctac tataaagaca 89220 catgcacacg tatgtttatt gcagcactat tcacaatagc aaagacttgg aaccaaccca 89280 aatgtccatc aatgtttgac cgaataaaga aaatgtggcg cgtgaacccg ggaggcggag 89340 cttgcagtga gccgagatcc cgccactgca ctccaccctg ggcgacagag cgagactccg 89400 tctcaaaaaa aaaaaaaaaa aaaaaggaaa tgtggcacat atacaccatg gaatactatg 89460 cagccataaa aaagaatgag tttatgtcct ttgcagggac atggatgaag ctggaaacca 89520 tcattctcag caaactaaca cagaaacaga aaaccaaaca ctgcatgttc tcactcacaa 89580 gtgggtgagt tccataatga gtgggtgagt tccacaagtt ccacaagttt cacaagtggg 89640 tgagttccac aagttctata atgagaacat atttgcacag ggaggggaac atcacacacc 89700 agggcctgtc ggggggttgg gggtcaaggg gaagaatagc attaggagaa atatctaatg 89760 tagatgacga gttgatgggt gcagcaaacc accatgacac atgtatacct atgtaacgaa 89820 cctgcacatt ctgcacatgt atcccagaac ttaaggtata ataaaaaaga aaaagaaaaa 89880 gaaaaaaaac cctgcctttt gctttggcag tcatcattcc ttccatcttc tcatgttttc 89940 ttatttaact cagtagttct caattgacag cacaaaagaa ttactcagga gagttcaaaa 90000 aacacctatg gctgactccc ccaagattct gatttccttg gtgtggggta gcctgggcat 90060 gaatattatt taaaaactcc tctcatgatt ctaaggtggt agccaggatt gaaaaatgct 90120 ggactttcaa gtttttgttt tctttctttt cttccaaaaa ggtgaagccc tgacttggga 90180 agaattcaaa tgcgagttag gcttatgttt gatgtcactg attcctaaag atcagtccat 90240 tgattctcct cattctcagg agagcatttg gtgtcaaaat cacagcccaa aactcttacc 90300 ctagttcagc atctaactct cttcagtcct gaaactgttt ttgtcactct gtccatataa 90360 tcacagtgtt gtagaaattt ccagctaaac attgtctcaa actttttgta cctagtttta 90420 aatcaaaatg tagtacaaaa ttattaaata caacgggctt taaaatattg agattttggt 90480 gatctttttt gtagaatgca aatactaatg aaactaattt tttcttttgc tttcaaacta 90540 tacatttctt ctaaaacttc tttcaaagta gaatttcata agtggaagaa cccttgaaga 90600 ttattttaat agaattcctt aattttagag atgaggaaac tgagactcaa atatattaat 90660 taatttatct aagtgtctta gtccattttg tgctgctata agagagcata cttgagactg 90720 ggtaatttat attgaacaga aatttattgg ctcacgattc tggaggttgg aaagtctgat 90780 atcaaggtgc tggcatctgg caagggcctt ctggatgtgt ctacatggtg gaaggcggaa 90840 gggccaagag gtaaaatgtg gctgaatttg tgcttctatt atggcatgaa tcccatccat 90900 gaaggtggag gcctcatggc ctaatcattt ctcacaggca ccacctttta atactgttac 90960 aatggcaatt acatttcaac atgagctttg gaggagacaa aaattcaaac catagcactg 91020 aagttataca actagttaag aagagagaac ctgagactga aaccctgatg ttttgactcc 91080 caatccagaa tgtttgatcc cctacatccc accgcttcgc tgtttccatt cctttctcct 91140 gttttcatct attttcacta agagggcaag atatttgcta actgctacac acccaaattg 91200 tataccaggc aggtcagaat gactctaaca ttttatttaa tgaggcagaa taaaatatct 91260 tcctactaaa cagtgacaag tgtttgtttt aaaaaaaagt attgtgcaca aaaaaaaaaa 91320 ctactttcag cataggctat attttacaaa ataaatttac agtgggaacc acagagctat 91380 ttagagtgtc tggtataaat gattttattg ttactctgct tttttgaaaa agaagtgtgt 91440 gaagcagagg taagtagtac tgaggaaata ataactaaaa tactaaggac gagatgcaca 91500 tgggaaaagt tcttcattaa ctgtaacgtg gtggagaaat gtatgttcta gacaggtcaa 91560 tcatggaatt agaaaaagtt gggatcttgg attgttgagt tcaaatcctt agttttaaaa 91620 ctgaagactt caaattttga ttgactacag atcaatcaac aacctgttgg agttggaaac 91680 ttgaatctga ttctccatcc ttgtttggga tatgaaaaaa aggaagacat ttaagagtat 91740 ttttttattt atgaaactaa tgtatcatca tgtaaaaata tgaaatagaa agtgttaaaa 91800 attataaaga aacaagaatg tgtttttata atctcatttt cttactttac gtaagatggt 91860 aagtctattt tggaattaat tgtttttaag aatagtatta taattcaatg ttagataaag 91920 atttatttaa ccctttcccc tttaacaagt gtttgggttt tttaagtttg cttccaagtt 91980 ttcggtaaat gatgcttcaa tggatatctc tgtttgttat cttagtatgt atcttagatt 92040 aattcctcaa gataaatatt taaaggtatg gtatatgtaa tattcttgat acatacttcc 92100 atatttccct ccagaaatgt gtgcacctat ttaaatgtgt gtggaggtgc acattttaac 92160 attcctcatt attctggctg ccttctataa atcaagctac cctggtatta tggctctcct 92220 ccagaaatct aatcatttaa acacatgaag tgaatgtgtg aatggacaat taagtgctgg 92280 ccaaatgtgg aaaaatgtta agtgtaaatc aaaggcaact gaaacgttaa atacaccttc 92340 cattcctccg ccacatccat gctctttccc atactccaca tctgctcact aaaattggaa 92400 ataaactgta atgaaccaga aatgtctgac ttactggtgt gtttaggtga gttttattga 92460 aacactgact gaccccacca ctctaatacc atcaccttaa tgtttgtatc ttagattaat 92520 tcctcaagat aaatatttaa acgtatggta tatgtaatat tattgataca tacttccata 92580 gttccagcaa ccacttgtca tcctgtgtcc cccaaggaca ctgcaatgac tgtcacagtg 92640 acttgtgctc ggttgaggag caagtggtgg ctgaaatcca gccccagtca gctccccaaa 92700 ccaaaccact tttacacagt gtctatgtgt aaagttggtt tgctttgggg agattgatcc 92760 ccataaggga tcagcaccag ccctgtgtct atctcttctt ctcctgggga gatgttggct 92820 attttgctag ctggagaagg gcacgcaatt tgttgtcagg agacaggttc ttaagttcca 92880 ttggtacatg cagggcaaga caggcagagg gaatctgtca ctgctacagg cacttcataa 92940 gcccaggtat agacgataat tgaaatggat tgatttcata gtagtctaat acagagtggt 93000 gctacaatct ctgtatgtgc ctatttagaa aataacttca tatttaattc ttcactttac 93060 ataaaagata tgtgtattaa atacaccttt tattttagaa cagttttaga ttttagattt 93120 aaattgggaa gacagtagag atttcctatc taacccacac ccagctcccg tattagtaac 93180 taacatcttg cattagtatg gtatattaca attaatgaac caatactgtt attttattat 93240 taacttaatt catgctttat tccagttccc ttagtttcta cccaatgtcc gttttctatt 93300 ccagtatccc atccagaata ccacattaca ttctgttgcc atgagtttct cagattttcc 93360 atgtttttga tgaccttgac agttttgagg aatactggtc aagcgttttg tagaatgtac 93420 ctcaactgag atttgtctca tgtttttctc atgattaact tggtattaca ggtgttttga 93480 gaggaagacc acagaaatga aatgccattc ttattacatc atatcaagca tatattctaa 93540 caatatgatt tatgacaact aatgttgacc ttggccaact ggctggggta gtatttgtct 93600 agtttctcct ctgtaaagtc cttccttacc ccctttccac actgtactct ttgaaggaag 93660 tcactctgca cagctcacaa tgaaggagtg gggagctatg cttcccctct ttgagagttg 93720 tgtatgtaca caaattattt ggaattcttc tgcatgggag atttgtctat tctcccctat 93780 ttatttattt attgaattat ttatatcagt atagcttcat ggatatttat tttagacttt 93840 gggctaaaaa acaatactac tttattttat tgttcaaatt gttccagctt ctagaagtta 93900 tatttttata gagaagatat gtttttaaat ataaaaacac tttaaaaaaa tgaagtcaac 93960 aggataaaat atttttaaat tttccttaat gggtgttctt tgtaccatgt ttccatcaaa 94020 taacattctg attgaaatct aaaaattagt gtttgtattt taagtgctaa gatcagagaa 94080 aaagtcacaa gtttcccaga ctgagttagg caacatgtga ctcagagtta taaggaatac 94140 ctttcccatt cctgcattgc aaccagtgtt acagttacag aagtgactag tgtaacttcc 94200 cctcctgggt tccagctgcc aggacttact ttagttcttt taacatatcc ttcccaccaa 94260 agataagttt tttgaacagt ttccccatga gtgctccccc caccccaact tgtgcctttt 94320 attcatgtct ttataatatt tattggttgg ctggtgcaat tgcagaggtt ggcaagtctg 94380 aaatttgtag agcaggccag caggctggaa actcaggcag gagttaatgc tacattctag 94440 ggacattttt ttcttctctg gaaacttcag tttttgctga caagcttttc aactgattgg 94500 gcaaggccca cccatgttat gagggggaac tgtacaatca gttgtcattt aagccaatca 94560 gtcaactgat ggttggtgtc aaccatatct tcagaatacc ttcactacaa catctagact 94620 catgtttgat taaataactg ggtgccataa ccttggcaag ttgacacctg aaattggcca 94680 tcacagtgac caagacagaa agtgtaatga gcaggaaagc accccagtga caggacagtg 94740 aaagatgagc ctggagacgg ggagtgggag gagtgctttg acagaatggt caagagagat 94800 ggcatctggg tggagatatg aaaagatgta aaagaaggga aggaaccagt tctgccaaga 94860 atttatactt ctacaatttc ccagatgata ttgatgctgt tgccctggag cccatacttt 94920 gagaaccaca gagtaagggt atacctctgt tattatccaa tgaatcctga gaaagcccat 94980 taatatctca gtgtgaccat tttttctcaa aattcctacc tcacatgctc tgaggggctg 95040 gcagcttttc tgggaaggta aaatctcaag agggaggctt tgaatgattc caggacaaag 95100 tgaagataac atactaccgc aggtaaagtc taggtttact tggaggtggc tcaaaacaca 95160 aatcctgtca attttaatga cacatgaggc catgactctg ggtcgtcact ctgggcaagc 95220 cattgaaccc attagaacct cagttttccc atctgtacaa aaagaggtga taatgggtaa 95280 gcaatcctgg actgcattgt ggtagtgcca tcaagcaatg agatttgtca ggaaggaagt 95340 gtgattcaag tacaggcact ttgttatctg atgcctgtgt gttgagtgtg aaggaggggt 95400 taattattcc tctattcatg tcctttctat tctcaaaatt tcttatgtgg gaggaaaatc 95460 ttggtgcggt aaagatcaca gccaccctgg ggtcagacag aggactgtgt caagcttggt 95520 aagcgtcacc attcaggtga gtgggaaaga gactgaaccc cattaaacca gatgacctcc 95580 aaggccctgc ccgccccaac atctgagggc tgcctggctt gtctgcacag ggtgctcaca 95640 gtactcctga ctttgacata attttaacat taaagtcaca aggatgccct ggatcacaac 95700 tgctggagaa gagatggtag tgggatttgt ttcccaggag actttctgat tctagtgggg 95760 ccaggaccaa cctccaaaat aagaggtctt tgcaactgct gcgagcctcc tggcacctct 95820 accctctagc gagaggctgc ctctcctgcc ccaccccggt ttcaagcacg ctgcagggca 95880 ggaactcact gtgctggcaa aggtgagctg gagacctggc acggcataaa gcttttttaa 95940 ctgacccttt ttaatttcat cttccctgga cttaatctag agagtcattg atgaaacaaa 96000 catgccattt tctcccgatt tcacgctttt aaatgtcaac aacaaacaaa cgtttatata 96060 cacaaatgtt gctgaaggag acttttggct ttagacaagg gtaaaaactg aacctcttag 96120 tgtgactttg gttgattttt taaaaaatct gtaatttgac atataaagaa ttattaagac 96180 tttttttttt tttctggtag gcattgaatg tgtccttgaa aagaaaaaaa atatgctcag 96240 tttcaatctt ctgtctatgg gtagctagtt atcccagcct tagttattga ataaggagtc 96300 ttttcaccat tgcttatttt attttacttt ttgagatggg gtcttgctct gtcacccagg 96360 ctggagtgca gtggcacgat tttggctcac tgcaacctcc gcctcccagg ttcaagcgat 96420 tcccctgcct cagtctccca agtagtttgg attacacatg tgcaccacca cacctggcta 96480 atttttgtat tttgatagag acagggtttc accaagttgg ccaggctggt cgtgaactcc 96540 tgacctcagt tgatccaccc cacttggcct cccaaagtac tgggattaca ggcatgagcc 96600 accgtgcctg gctgcattgc ttatttttgt cagctttgtc aaagatcaga tagttgtagg 96660 tgtgtggtct tatttctggg ctctctattc tgttccatca gtctatgtgt ctgtttgtgt 96720 atcagtgcca tgttgttttg gttattgtag ccctgtagta tggtttgaag ttggataaca 96780 tgatgcttcc agctttgttc tttttgctta gattgtcttg gctatttggg atcttttttt 96840 ggttccatat gaattttaaa atagtttttt tctagttctg tgaagtatgt cactggtagt 96900 ttgataggaa tagcattgaa tctataagtt gctttgagca gtatggccct tttattgata 96960 ttgattcttc ctattcatga gcatggaatg ttttttccat ttgtttgtgt catctctgat 97020 ttatttgagc agggttttgt agttcttctt gtagagaatt tcacctcccg ggttagctgt 97080 attcctaggt gttttatttc ttttgtggca attgtgaatg ggattgtgtt cctgatttgg 97140 ctctttgctt gactattttt ggtgtatagg aaggctaagt gatttctgta tgttgatttt 97200 gtgtcctgag agtttgctga agttgtttat cagctgaagg agcttttggg ccaacactat 97260 ggggttttct aaatataggg acatgtcatc tgcaaatagg gatagtttga ctacctctct 97320 ttctatttgg atgtgctata tttctttctc ttgcctgatt gctctggcca ggacttctaa 97380 tactatgttg aataggagtg gtgagagagg gcatcatttt cttgtaactg gaccccttcc 97440 ttacaccata tataaaaact aactcaagat ggattaaaga cttaaatgaa aagcccaaaa 97500 ctctaagaac cctggaagac tactgaggca ataccatctt agacatagga atgggcaaaa 97560 atttcatgat gaagatgaca aaagcaattg caacaaaagc agaaattgag aaatgagatc 97620 taattatact aaagagcttc tatataacaa ataaaactat caacagagta aacagacaac 97680 ctacagaatg ggagaaaatt tttgcaaact atgcgtctaa ccaaggtcta ctatccagca 97740 tctataagga acttaaattt acaagaaaaa aacaacctca ttaaaaagca ggcaaagggc 97800 atgaacagac acttttcaac agaagacata catgtggcca acaagcatat gaaaaaagct 97860 cagcatcact gatcattaga gaaatgcaaa tcaaaaccac aatgagatac catctcacac 97920 caatcagagt ggttgttatt aaaaagtcaa aatataatag atgctggtga agttgcagag 97980 aaatgggaac acttatataa tgttggtggg agtgtaaatt agttcaatca ttgtgaaaaa 98040 cagtatgatg attcctcaaa gacctaaaaa tacaactacc attcaaccta gcaattccat 98100 gactgggtat atacccaaat ggatataaat tgttctatca taacgacaca tacatgcata 98160 tgttcattgc agcactattc acaatagcaa agacatggaa tcaatctaaa tgcccattga 98220 tggtagactg gataaagaaa atgtggtaca tatacatgat agaatactat gcagccacca 98280 aaaagaatga gatcatgtcc ttttcaggaa catggaagga gctggaggcc attatcctta 98340 gcaaactaat gcaggaacag aaaacctaat actgcatgtt ctcacttgta agtgggagct 98400 acatgattag aattcatgga cacatagaga ggaataacag acactggggc ctatcagagg 98460 gtggagggtg gaaggaggga gaggatcagg aaaaataact aatgggtact aggcttaata 98520 cctgggtgat gaaataatct gtacaacaaa cccccatgac acaagtttac ctatgaaaca 98580 aacctgcacg tgtacccctg aacttaaaat aaaagttaaa aaaaaacccc aaaaggtgaa 98640 gtgttggtga ggatgtggag aaaagggaac ccttattaca caattagtgg gaatgtaaat 98700 tagtgcagcc attttggaaa atagccaagg aaaatttttt tattgagtca gatgatgtta 98760 ccttacagca atagcttcca aaggggatgt cctgaatagt agaacttctc tttacatttt 98820 caaacctctt tttactttct gattttgagt ttcataatga acatgtatca atacaatagc 98880 acactatgta ttttataaat gaacaaatat gggaaaaata agatatgttc actttcctgg 98940 ctgaccctag ttagtctaaa ctatcagtta taggatccat ttgttctaaa tattgaaggc 99000 attgttgggg gcagtgggga gggtgaatga tagacgcaaa ttccttgaag gaatagaaat 99060 gtgactacta tgctgaaaag caggacccat ggagtataaa tagagtattc actgtgcttt 99120 tacatttgtt tccctggagg aaacgtaaaa caaatctcaa gactttctgg tcatttctaa 99180 gtcataaacg gccactagtc actaatttat ataaccagcc caatgtaaat atcaaacgtg 99240 tgagtttcat ttcatctcac aactcctccc ctttcccagt tctggcccca tacaagcccg 99300 ctgcctgcag tgtaatggag gaagatggtt tctttttcct tccctcccat ttatttgtct 99360 ttgtgcatct taaagccagc ctgaatttct actccctaca aggttgaagt gggtgggtca 99420 ggaggtgggg agagagctaa ggaacgttgg cgtgagttgt tgttgtgttt gagtctggaa 99480 ggtgttggga gctgcccccc ctcactcagg gcctcattta tgggctcttc ggataacccc 99540 catgctctag cactgggatc ttgccctgtg gatccctcca tgcaggtggc accacaccct 99600 ctggctggtt gtgatgggcc ttctcagctt tgagaattag caacacactt cctattgaag 99660 tcatctgtcc ctgtgggtag cccacttggg ctggatgcaa actgaacctg cactgattct 99720 ctcttgcatg tggcccacat gagctccatt ttcctccgca aactttgggt gcacagcccc 99780 acgacgacac agacagcttt tcttgcgtgc caccaaagtg gtgggccaga gttctcttat 99840 ccttaagatt ttcaggtgtc accacgtcca ccaattcttg gcagacatga atcaatactt 99900 ccaagggttt tggtgaagcc cttttccctg ggctgcagat gagggcagcc atgtcctgtc 99960 tcttccacct gttgtggaag gggttcatgg caaacatctt cgaacatcct ctaatttccc 100020 aattcttgat cctttcgtat gcttgatgtg tgagagagaa gagagaagag agaaacgctt 100080 cttgctgctt tttttttttt taatcccaca tggtgacctt agactttact ttggaatgtg 100140 ccatttaata tctggggacc tcagcccaac acagggacta aatagctctg ttttaacatt 100200 ttgtttatat acacacattc atttgaccaa atgaacatgt tccagctttt ttaacccttg 100260 cccagcaaat cacttaattc agttaataaa aagactaaaa taatgaggcc aaccttattg 100320 gccacgaaca tctgttgggt attcctaaat tgatccctga gttaatctcc acctttaagg 100380 agtttataat tttatttggc aaattgatgt tataatgaaa ttcctgggca tgaaaaaaac 100440 ctaactatgt aatgttggat agtgtgagtt ttcccaaaag taccagtata agcaataaat 100500 gctataactg atcatgaatt gtttacagtg attgagtaga atcattgcat ctggtcatga 100560 atagaaagag cacctcccag acggctggtc tgctgccagg tgtgcagttt taggggtctc 100620 cacactcatt ctattcacat cttttgactt tatcagctgt gtggtggatc tgtggttaca 100680 ggctgatgtg gtttggctgt gacctcgctc aaatctcatc ttgaattgta gctcccataa 100740 ttcccacgtg tcatgggagg gatccagtcg gaggtaattg aatcacgggg gcgggtctct 100800 cccgtgctgt tctcgtggta atgaataagt ctcacgagat ctgatggttt tataaatggg 100860 agttctcttt cacgagctct cttgcctgcc gccatgtaag aagcgccttt gctcttcctt 100920 tgtcttctgc catgattgtg aggccttccc agccatgtgg aactgtgagt ccattaaacc 100980 tctttccttt ataaattacc cagtcttgga tatgtcttta ttagcagtgt gaaaatggac 101040 taatacatga gccacattgt tacagagttt ctgaaggtca ttaagagaag tccatgctgt 101100 gggctgagct gggactcaag aatctcaaag gagagccagt gcaatcaaca cgaagggccc 101160 atcttgaact cctaaggcag ggcagagctg ggtcttatgg agacatgtgg ctttcaggta 101220 atccagtgag cacctgtgtt ttcctcctat aattcttgag gaatggatat tgttctatat 101280 ttcagatagt ataataataa atacctggaa aatactgtat gaccccaaac aacaggtaaa 101340 atgtcaaaaa aaacctttta tctacacaaa gttagacaac aaattcaaat aatcttatcc 101400 gtttattcat tctcttccaa tacaatcatg tatcatttaa tgatggggat gagtttggag 101460 gaaggtgttg ttaggagatt ttgtcatggt gcaaacatca tcaagtatac ttatgccaac 101520 ctcagtggta tagcctacta cacatctagg cttggatagt acagcctgtt gctcctaggc 101580 tataaacctg tacagcatgt tactgtcctg aatactgcgg caactataaa ataatggtaa 101640 gtatttgtat atctaaacac acttcaacat agaaaaggca cagtgaaaat atggtataag 101700 agataaaaaa tggtccacct gtacaaggca cttgccagaa tggagcttgc aggactggaa 101760 gttgctctgg gagagtcagc gaatggctga tgagtgaatg tgaaggccta gggcattatt 101820 gtatgctact gtaaacttta taaacactgt gcacttagga tacactaaat ttattaaaaa 101880 tttttctttc ttcaatcaat aataagtgaa cattagctta ctgtattttt ttttttactt 101940 tataaacttt aatttttttt tagagatagg gtcttgctct gttggccagg ctggagtgca 102000 gtggcacaat catagttcac tacaacattg aactcctagg cttaagcaat cctcacacct 102060 cagcctcctg ggtagctggt actgcagacg tacactactg cacccagcta atttttaaat 102120 tttttgtagc gactgggttc tgctatgttg accaggctgg tcttgaactc ctgactcaag 102180 caatcctcct gcctcagcct cccagcatgc tgggattata ggtgtgagct actgcacttg 102240 gcctaaactc taatttttaa aatcttcttg actgttttat aataacactt agtttgaaac 102300 acaaacacat tgtacagctg tacaaaaatg ttttctttct ttacatcctt attctataag 102360 cttttttctg tttaagtttt taaaaatgtt ttagtctgag tgcgggggct cacgcctgta 102420 atcctagcac tttgggaggc cgaggcgggc agatcatgag gtcaggagat cgagaccatc 102480 ctggctaaca cggtgaaacc ctgtctctac taaaaataca aaaaaattag ccgggcatgg 102540 tggtgtgcac ctgcagtccc agctactcgg gcggctgagg caggagaatg gcatgaaccc 102600 aggaggcgga gcttgcagtg agctgagttt gcaccactgc actccagcct gggcgacaga 102660 acgagactct atctcaaaaa aaaaaaaaaa agttttaaac ctttttaaaa aatcaaagtc 102720 acagacacat gcattagcct aggcctaccc agggtcagga tcatcaatgt cactgtcttc 102780 cccttccaca tcttgtccca ctggaaagtc ctcagggaca gtaacacccc tggagctgtc 102840 atctcctctg ataataatat gggcttctgg aagacctcca gaaggacctg cctcctgcct 102900 aatgctgttt tacaggtaat atttttttct agtagaagga gtacactaaa ataatgataa 102960 aaactgtagt aaagtaaata tataaattag tcatatagtc atttattatc ataatcatta 103020 tgtactgtac ataattgtat tgccagactt ttatacaact ggtggcacaa taggtttgct 103080 tacaccagca tcaccacaca cgtgagtaat gtgttgtgct gtgacattag gacagctaca 103140 atgtcaggag gcaataggaa tttttcagct ccattataac cttacaagac cactgtcata 103200 tctgcagtac aaaacatcat tatgtggtgc atgactatat ttactgagca ccaaatatgt 103260 gcccaggcag tgtgctaggg gctggaagtg acctcgaagt ctagtaaaaa aaccacaaca 103320 gtaaaacaat atgtgtaatt caaagtgaca tatcctgtaa tagctggttg cctacctgct 103380 ccccagagag aaattaaacc tgcttgctta acttattaat tttaaattca tgtacttgca 103440 atataaaaac atattttaaa acatattagg agaataggat gtcttctgta gtgataggct 103500 atttaatgtt ctcttcactg tgttctaaaa aaatcgtgat cgagtgtaac aaaatgggga 103560 agggagggtt agcataaact ctcctttgat gtctatgctg tggatcagaa aactcatgaa 103620 tatgttaaca actggatttt ctcctaatat gaaaacaact ctttggcttc ttttgcaaat 103680 gtgaaaagtt aaccataaat ataagacctt ttctttccac taaaactagg gcacaatcat 103740 tgttttcctc ttattggagt ccaaatgggt ttccataatc ttcagatcta gtagttgtat 103800 ttatcgatga cataaatgga aagactaaaa gataaagtta agaaaaattc agtggtttat 103860 ggcttcaact ctactgataa ttttgtatat aaagggatcc taaattagac tgtacacaca 103920 tttgccattt gagttccaag cattttagca atagatcaaa agatcttaat gcctgatagt 103980 tgaaagatta cttccaaatt ttttttattt ttgtgaaagc caaagtcctt ttctcaacat 104040 gacagtcaca attttgtcaa caatctaccc gttatttaca aaggtttaaa atctgataat 104100 agatatttac ttggactata caatgtctca gtgggagcaa tagatggttt acaatgggtc 104160 tgaaaatgtt gcaaatagtc aaaactggca ttgcaacaat tcatttccaa aaacacacta 104220 gactcgtgag tttttggttt ttaagtttat atagcttgct tctggtgtta acgttctcca 104280 cacctaaggt gccaacatgc atggctactc tttgtcccca gagaaacatt gctaatttgt 104340 accaaatttc aatgatgtgt caagcaaact gtcattttgg aatgatagta agcacgcctt 104400 caacaacagc tctttatttc gtccaaaacc tttgggccac acaattctga cctttatcac 104460 actctcagta cctttcattc attattagct tgtgcttctg gggccccggg aattgtcaac 104520 tatggtcaaa ataatggagc aaaatagcaa gaagaacttg cgtttcctat atcattgcat 104580 ttaatctttg caacaactct ttgaggtgga aattgcccca attttataga ttcagcttaa 104640 agaccttgat ttgtccaaga tcacacaacc actaggaggt ataatgttca aataaaaatg 104700 tctgaaaaga gctgggtgtg gtgggtcatg cctgtaatcc cagcacgttg ggaggctgag 104760 gtggggggat cacctgaggt caggagtttg aaaccagcct gggcaacatg gcgaaacccc 104820 gcctctacta aaaatacaaa aattagctgg gtgtggtggt gcatacatgt aatcccagct 104880 acttgggaga ctgaggcacg agaattgaat gaaccctgtg aggcagaggt tgcagtgagc 104940 tgaaatcgca ccactgcact ccagcccagg cggcagagtg agactccatc tcaaaaaaaa 105000 aaaaaaaaaa aaatctggaa agatagatta cttggcctca atcatagtaa aaaagtgtca 105060 gttaaaactg catggagaga tactattttg aaaagcatca aaaagttcga agatccatca 105120 tatttgtaag gctatgggag tttaaattgt acaggcgtta tgaaggcatt tggttacatc 105180 taccaaaatt aacaccgcac atatttactc atgtgcaaat tgacttatgt acaaatttac 105240 taattgtagc attgttgata attgtaaaat attaggaaca cacctaattg ccattaatgg 105300 ggaactggta aaataaacta gaattcctct gtgcatggaa tactatgcag tcatcaaaaa 105360 tgacgaagat gtggccgggt gcggtggctc acgcctgtaa tccagcactt tgggaggccg 105420 aggtgggcgg atcatgaggt caggagatca aaatcatcct ggctaacaca gtgaaacccc 105480 atctcttcta aaaataccaa aaaaaaaaaa ccaaaacaca attagccggg catggtggcg 105540 ggtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg aacccaggag 105600 gcggagcttg cagtgagccg agattgggcc actgcacgcc agcctgggtg acagagtgag 105660 actccgtctc aaaaaaaaaa aaaagaaaac agaacaaaac aaaaaatgag gaagatgttt 105720 atttagtgaa atagaaagat atccaagata tgttgctaat aaaaacaaaa aaaaacacat 105780 ggcacaaata aggtgcatgt tactatctgg gtcttttaaa aaggggtgtg gaagaatgtg 105840 tgtgtgtgtt ttcttcaata tgtgtagaat atctctggaa ggaaatttaa aaactggcga 105900 cctcagctgt ctccagagag ggaaaattgg tgggttgcag gcagaggtga aagattttcc 105960 cactatgact ttgaaaatat cttttcaagt ttaaagcacc aactgcatta tatatcaaga 106020 gtaaataaaa tacaatttta aaatgaaatg gcatttgtaa aacacttgat agatgttcag 106080 ttaacagcca tcaggattta ttagtaattg tggtttttgc cattaaaagt aattttaaaa 106140 gtaatggttt tgccattagt tttaatgaca aaaaccacaa ttagttttgc accaaccaaa 106200 taccttacgc ttctggtgag ggctcagaag agagatcata agtaaagaac actagaaagg 106260 atgtttaata ttatttccct ttttaaaact ggtggttgtc aaagcagtct gaaggaaaag 106320 tctccagaac tggtgatcat gttcacatag cagtagtttg gagtcaacag aaatcatctt 106380 caccatcaac ctagctccga aagaggccga gccaatctag ttcccttggc caaccacctt 106440 cctcccaacc tatacgttgg ggtgatccac tacaaagctc tcaagagtat acacaatgct 106500 actacagtca ttgtgagtga gatctgaagg gagcataggc taggactcat gagattatag 106560 ttcagagttt ctactgtaat tcctttcagc aaagtgaaga gcatgtcact ggggttacaa 106620 gtgttactgg ctacttagct agtgctagat tacccaaaaa agtaaccggg tctcatgggc 106680 agaggtggga aagtctgtta agcacatagt gaaggatgaa tctgggctga ttggaaaaca 106740 tttgtttgaa tgaatgtagc atttatttcc aagaataagc atgtccagac tgattgagca 106800 agagttatat ttagttcagt cgttctgatg tccattttga gaaagctaaa ccagcatgcc 106860 agaaggggtc aaagatcaca ttttgcatga aagaaaagcc aatggaaatg ggactgttag 106920 acttaaactt ttgggtattt tacactagga cttagaaagg actttattcc tttttatatt 106980 ttctgtctct agcattgcaa gtagcaacag agtgaatttt tggtatttgg aatactctct 107040 cctcattttt cctttgggaa aatcattagc ctatttgatt tgactgctgt tgaatatgtt 107100 ccatgacatc cataagtcta ccttcaggca ttgcttgtgc ttgtttatta catatgatta 107160 attgcttaca taagaacaat gatgatccct gcagggggag gagggatgtg aagaacaact 107220 tacttaggca ttccaggggc taacaaggga tggtttgata cagctcattc ttgttttgaa 107280 tcttcatgcc tcttgagaaa gaaaggagca gaatatgctt tgcatggcgc tatgtcctcc 107340 caggtcctat gttttctttt ttgtatttta tcagttctct acgtaaggat tttctcagtt 107400 taatataatt tccattttta aaattcaaat acctacatat gaggtgggaa aggaaattaa 107460 tcagatgcat tcctataaac tgcagactta aattaagacc ttgagcaaac tggcattttg 107520 atgacttgag gattcagtgg gtgggacagt tgtacatctt gaactctggg tacactgccg 107580 aaagcgaggc ctgagaaggc tgtgttgagg aaggagtgtc agtgactgag cctgttggaa 107640 agggaggctg agagagatga ggacacatac gtaagggaga acacattggc tggccaggtg 107700 tttttttttc tgctgtggat tttgattaga attctgggtc tcattaagtg acccatgttg 107760 aatagagatt ggatagggct ggcttggaaa gccctcagtg aagagatgaa ctcgacagca 107820 tgataaggaa gtagatgcaa attcaggaca ggaaatggag aagggcaggg tgagaaaagg 107880 gaacaaattt acaatttgtg ccattagcca tttattagaa tttggtataa gaatttgtgg 107940 aattattgtt tccttctgga tttatggtac aaaaacctac tgacaagtgt cactaaaagt 108000 gatgtcttta ttcaattatc aaccaaaagt tttacactaa attcttttga gtctttgaat 108060 gtttatgtta tttccaataa tctttccagt tcttttaaaa ggctgatttt taggaaggct 108120 agcacttttt gatcacagaa tagtttcccc aatgagtatg atagcttcaa tatctttcaa 108180 attagattct tttggaaatt gaactgtgtc aaatcaaata aaacaagtag ggttttttgc 108240 tgttattgtt gaaggtatta tatttgcaag tttgtacaat ttagcagata taggaaaggt 108300 ctaatttttt tctttagcta gaatgttcag ttcaaattat acagatataa gcatgagacc 108360 taaatgaact ctcttctgat gagtaatgaa tggaaggtag attactcatt tcttcatgtt 108420 caaaaaacaa attatgtctc tgaacacagt tgtttcaatg tttttaactt atgttctcaa 108480 gctcttccca tttctttatc agtgatttgg gaatgtgaag gcagtcttgt tgtagtttcc 108540 aaagatttag gcatttttga gactctaaga atagttcatt aagccaccaa ttagtccctt 108600 aattttattt aagctgagca agcaaggccc acactaaaag tcagaagaat gcggcatcta 108660 cccagagagg ctgagggtgg gatagaaaga aggaggcact ccaagtttgg agacacagat 108720 tctattccag ttcctcaagc tgcatgacct tcagcaagtc tcctgtgttg ttcaggaccc 108780 cagtttcttt ataagtgcaa tgaagagttt ggactcaaca acttataaag aaacattcat 108840 tctaattgtc tattgtgtga aaagaatgtg agttgttcta gaaaatatga atctgctccc 108900 caattgtcct ccaagctctg gttctaaatt tcagttatta tagttacttc tttcgaggta 108960 aatcattgag gaagtcagtt aatgcagaga tgatgtctgg aaggagttta caagttcatt 109020 gttcaaatag tatttgttgg gggccaacta caactacaca tcagggattg tgctcacatt 109080 ggactagtgt ctttggaaaa cagagtcctt gtgtgccctt tttgaattta caggccaact 109140 tggggaagca gagagacaaa taggaaatcc aacagcatga taagtagtat aatgagaatg 109200 tttagggaga tacgagcatt tataggagta gcactcaaca ggaaatcaag gaaggcttcc 109260 tggtggctat gatgtctcaa gggagacttg aagcatgagt aggagtatgt cagatgaaaa 109320 gggatgggag gaagatttca ggtagggtaa tttgcatacg tgaatattta gacccagaga 109380 aagtccagag ggactgagga acttaaaaga aatccagtat gggaggagca tagtacctgt 109440 tggggagggt ggggactctt gataaatgag gatagtaatt caagttcttt ggctcttgag 109500 ttacttttgg acaagttgag cttcaagtag ctagtacata ggaggagctt aataaatatt 109560 tattgaatga atgaacatgt aagtaaaaat gtctaatagg tacctggcaa agtggacttc 109620 ctagtcagga aagagaggtt ggttggagat ttctattttg aaattttcaa tgtatatatg 109680 aaagtaaaaa cacaaggagt ggttgtgatc atccaggaga aggtatgcag aggagggaag 109740 agggtctagg ggctgaatcc tggggtaccc acacctgaga ggagggagag gaagaggggc 109800 tctcagaaga gcctgagcag gaagggccat tgtaatagga ctaaacacta agcccctgaa 109860 gtcagctctc tgggggcaga ggtttttgtt ctgtttattt tgggatgcct gctgttgacc 109920 agattatgct cccctaccca cccaaattca catattgaag ccctaacact caatgtgact 109980 gtatctggag atagggtctt tgggaggtaa ttatggttaa atgatgtttt aaggctggga 110040 ccctactctg ataggactgt ggccttataa aaagagctct ctctttttct gtcctcctcc 110100 ttctacctcc tccaggaccc accccaaccc cacactgaga aaataaatcg ctgttgttta 110160 aatcacccag tctatggtat tttgttacag tagcctgagc tgaccaaaac agttctccgc 110220 acttagaaat ggtcctggta aatacagcta atcaatattt ttttgagtga attgaatgaa 110280 tgagtcattc actggcatgc ttataaatgc attactccct ccacagtgtg attgtcattg 110340 agcaggttgg gagaagggag gagctctcgc aaacatggaa gtcctgggtg cttagggaga 110400 atgggaaggt gccgtggtca caaaatcgga agaaagagct gaaaggctga aaggctgaaa 110460 atgctaaact gctcaaatct cctctgtctt tttttaaaaa aaatcatttg gctaggctgg 110520 ctctgaaatt ggggatggtt cttggttgat tatgtggtgt gtgtgtgtgt gtgtgtgtgt 110580 gtgtgtaaag gcccttctta acattagata ggactatctg aatctaagtg aatttaggca 110640 caatctagat attgctcttc atagagaaat aatactctaa gctggcaatg aaattcctca 110700 agtaaacaac agataaaggg aaggagaggg acacagtgta acaataattg gaataattgg 110760 aattcttgta tcactcatgg cacttacagt gaaagtactt tctacattgt cttctattac 110820 atgcaacata ggtacattat ataaaaagat cctaaaatat tgttaaaaga aattttccca 110880 gaaaatgtaa gataaaagtt actaaattct attaagcttg caagttaaat ccaaatcatt 110940 cattgactca taatcaagaa cagtcatgct gcctgacaac caaaaaattc aaactgtctt 111000 catcaagtcc tgggtgggaa gccaggaaat gggatctgag atcacaggct ttgtgagagt 111060 cagggtcttt ggcgtgattc ttggtcacaa atcatgcatt tttttccttg gagagatagt 111120 gggaaagaaa aggctgttta aaaacatgtt aaagaatact gattccattt gacttcttgt 111180 taatgtgtac ccttgcagac ttgggtaaaa cttgatcatg ttaaaagcca ttgtacttaa 111240 agattcatga ctagagtgtt aggacaattc tgtggccttg ggggtcccat tgcagcaaga 111300 agagtctgac tgagaagagg atagctccgt cctttgatgc ctagtaacct gcatgcccag 111360 cactttgctg gctgggccat tggtaggaaa tgcggtacat gcacttcaat ctgtaagaga 111420 tcatggtcca tagagatcat agatttattt tgccacctgg cccagatggt gatagaagtc 111480 aggacaatgg ttgcctagag gggttgggag tttattagaa tgggacacaa agggaaattt 111540 ctggggtgat ggaaatactc tatactttca ttgggatgat tgttacatgg acatatccat 111600 ctgtcaaatt catcaaatgg tatgctttag atacatgtat ttcattgtat ataaattttg 111660 cctcaagaaa caaaaactca aggtcaggtg aaaaaagtcc aggagctaat caaaaaccct 111720 taaaataagt gaccaaacta tttgtgaaaa tgagcagaaa cttaaaggga aattctttgt 111780 tatttttcca cattagagga aaattgatgg tatcagataa atgctcaaaa ataagcttcc 111840 aaacagagca tttataatca gtacaataat aagtttgaac acagacaaac cttcatgtct 111900 cagagtgaag gaaccatttc tagtagtata agctattacg gagatagttc cacatttatt 111960 ttctttcatg tttcttttgg aggaataatg tttttgtaaa tgtaaaatgc ttttaatgga 112020 gctagagaag aagctatgtt tggtcatagt attatctgct tgcgaactaa aaattcagag 112080 ctctcttgtg aatcatgctg ccaagaattg cagacttaag cctcaagatt gtacgaattt 112140 aaattttgac tttatggcct cagttggcat gaagatacaa agataatctt ctagcaaaaa 112200 cagttttgaa agaccgggcg tgatggctca tgcctataat cccagcactt tgggaggttg 112260 aggcgggtgg atcacctgtg gtcaggagtt caggaccagc ctggccaaca tggtgaaatc 112320 ctgtctcaac taaacataca aaaaaattag ctgggtgtgg tggcggacac ctgtaatccc 112380 agctacttag ggaggctgag gcaggagaat cgcttgaacc caggaggcag aggttgcagt 112440 gagccgagat cacaccagtg tactccagcc tgggtgacaa aagtgaaact ctgtctcaaa 112500 aaaaaaaaaa aatggtagaa tgtcacatgg aaagttaact tttagagata gtaatccaga 112560 cacctataat attacattgt ccttttaagt atctatatca ataaattaac caacatttgt 112620 tgacttaaca tggccaggga cagtgctggg ttctcataat tcccaagtaa ttctagccag 112680 accttgtcct caaggagctt atgagcagca tgaggagata aaaaacagat aaataactct 112740 aattcaggaa gaatttgata aatgcatgat aactactact agaattcaga ggagaggaaa 112800 ttttctttga atagagacta aaggaaggaa taatgaatgt ggtagcattt gggctggacc 112860 tattacaaga ggcatgcttt cccctgacaa gccaagaaag tggggattta aggtagaaga 112920 aaagaaaagc cttgagttct tggagtatta aaattttgct tggctgaagc ataggttaca 112980 gtcggaggag atggactagg aaggatcgtt atgggcagag aggaagccct gaactcatgg 113040 gggaagctat gatttgggtt aaagacagag ctgggtcatg tcaagatgga tcctgaagca 113100 gtaaaaaaaa atccaagaaa gtaaacaggt tgcagggttt aggatgaagt ccgggaggaa 113160 agggcagagt ggtccttagg aggccgttag gacaggtaag gtaatgggtc tcaaagggag 113220 tggccgaaat gcaatggaaa aagagagatt gtaaagctag aaggcttagg aattgcctct 113280 tgattaggtg tggaaggcaa gggaaaatca gccctcgaag aagacagtga gattttaatc 113340 tgggtggctg gagagacagt gatgctgggc acagacacgg ggaagttgag aggaacacca 113400 tgtttgagaa tggtgactca tatttgaaca agcctgcaat gcccagcaga ccgctggaaa 113460 agtggggctg gagacacatt caacggagga gccagatcaa tctttaccct tcttcacctg 113520 agagagccag taagtcacgg ctggaacgtg tgtgtccagc aggagagggt agggagggaa 113580 gccaagagag ctgggagccc gagtgaagtt tttgccaaag gcagaagagg aaagtcggcg 113640 tagcacagta tactttccca cccatgctca ccaagcccag ggacaaggct caccaagatg 113700 agtttggaag agaatgctgg agagaaagtg gttaagaaaa ctgcctttac tgaacttctt 113760 gggctaactt tgattgtaag tctctgaaca atcaaagcct gtgaggagac agctaacctt 113820 cttattcttc ctatgtcaat agtgaacaat tgcagatccc ctttcctttc cttctccttt 113880 cccctgttcc tctctcctcc ctccctgaat actcttgctt ttttctggga ctggtctaga 113940 gcatgggtgg ccattgttga cctacaggag gcaccactgt caccaacaaa gggtaacagt 114000 ctttcttttc aatatttatt tatatccagt atttattttc aatactgact atggagagag 114060 ctctcctgtg ctcaaacact gcaatactgg gggtctttca aagcacaaaa acatatattt 114120 gcatgatggc atcattaaca tttttatggc tttctatttc ttttttgtac tggtctcaag 114180 agccactcat aaatctctca gtaactgcat agtgtcccag ggccagagac cggccactcc 114240 tggcattgtg attagagtca tttaatatcc aaggtggtga ctaatgtctg gcaacaaagc 114300 ctccattggg tgtcatgtgt cctgggaccc tgagcgtggg cactctagga gcacctcagt 114360 attgcgtgtt agtactatgg ccgagagaat agttgagaaa gtggtcaaga ggtggatcca 114420 tgtgaacgcc actgggaaat gagagacctc gttcccaatc acggtcagtg caactcgaaa 114480 gcctaaaatc agtttaaaac aaaggtatct acctttatct tatgttcata tcctaggctt 114540 ttaataatac gtatttttca catgtttaca gaaagcagtc aactgagcta ttcatggaaa 114600 ggtttgtggg tttggttaac gaagtggagg agtattacat ttcagctgga aacacatccc 114660 tagaatgcca aaacatttat tccaaagtct ggtttcctgg tgcaatcgga ggcatggcaa 114720 tgcctctgtt cagagactgg gggctagggc cagtaaggca tttgatccac atgtatccca 114780 gaaggctttt attgttaaat tatattcttt cggaaaaacc acccatgtcc tattttgtaa 114840 acttgatatc catacacttt tgactggcat tctattttag ccgtaagact atgattcaca 114900 gcaagcctgt ttttcctctt gcttggggtg gcagcagaaa gcatagggta ctttccagcc 114960 tccaagggta ggggcaaagg ggctggggtt tctcctcccc agtacagctt tctctggctg 115020 tgccacactg ctccctgtga gcagacagca agtctcccct cactccccac tgccattcat 115080 ccagcgctgt gcagtagccc agctgcgtgt ctgccgggag gggctgccaa gtgccctgcc 115140 tactggctgc ttcccgaatc cctgccattc cacgcacaaa cacatccaca cactctctct 115200 gcctagttca cacactgagc cactcgcaca tgcgagcaca ttccttcctt ccttctcact 115260 ctctcggccc ttgacttcta caagcccatg gaacatttct ggaaagacgt tcttgatcca 115320 gcagggtagg cttgttttga tttctctctc tgtagcttta gcattttgag aaagcaactt 115380 acctttctgg ctagtgtctg tatcctagca gggagatgag gattgctgtt ctccatgggg 115440 gtatgtgtgt gtctcctttt tctttcagga cttgtaggat tctttgtgcc atttgcatat 115500 aatttggcag gttcacattt tttaagagcc ctatgaagtg ctttttgcat gtgttttaaa 115560 aaggcatttg aaaattgaaa gtgtgattta tggaaattaa atcatctgta aaaaattgct 115620 ttggaaagta atgattgctg gccataaagg gaaatatctg cgatgcacct aatgtgtttt 115680 taacccttta tttgctgaca atctatagtc attaatgcta aactcgattt tggcttcagc 115740 tacatttgca tattgtccaa caatggtcta tttttgtaag aattagataa aatgtatact 115800 tgatataaaa tagtcaaaaa tgtaactctt agtaacagta agcttggcat ttagatagac 115860 catgaacact tcgtcagata ctctgttggg tgtttgggat agcaattaaa acaaagtatt 115920 gatagttgta tcagagtcta ttaggctgca gcaaaggaag tttattcaaa agtataaact 115980 atccaagatt atagacgcat gatatacttc acctattttt tgtctcctta atatgtatat 116040 atatatatat atatatatat atacacatat atgtgtgtgt gtatgtgcgt gtgcatgttt 116100 aacttttaat tcagttaaaa acttttttct atttgttttt catctggata tttgattctg 116160 catatcctag cccaagtgaa ccgagaagat cgagttgtag gactaaagga tagacatgca 116220 gaaatgcatt ttaaaaatct gttagctgga ccagaccgac aatgtaacat aattgccaaa 116280 gctttggttc gtgacctgag gttatgtttg gtatgaaaag gtcacatttt atattcagtt 116340 ttctgaagtt ttggttgcat aaccaacctg tggaaggcat gaacacccat gtgcgcccta 116400 accaaaggtt tttctgaatc atccttcaca tgagaattcc taatgggacc aagtacagta 116460 ctgtggtcca acataaacac acaagtcagg ctgagagaat ctcagaaggt tgtggaaggg 116520 tctatctact ttgggagcat tttgcagagg aagaaactga ggtcctggca ggttgcattc 116580 tcctgatggc aaaatgcagc tcttcctata tgtataccct gaatctccgc ccccttcccc 116640 tcagatgccc cctgtcagtt cccccagctg ctaaatatag ctgtctgtgg ctggctgcgt 116700 atgcaaccgc acaccccatt ctatctgccc tatctcggtt acagtgtagt cctccccagg 116760 gtcatcctat gtacacacta cgtatttcta gccaacgagg agggggaatc aaacagaaag 116820 agagacaaac agagatatat cggagtctgg cacggggcac ataaggcagc acattagaga 116880 aagccggccc ctggatccgt ctttcgcgtt tattttaagc ccagtcttcc ctgggccacc 116940 tttagcagat cctcgtgcgc ccccgccccc tggccgtgaa actcagcctc tatccagcag 117000 cgacgacaag taaagtaaag ttcagggaag ctgctctttg ggatcgctcc aaatcgagtt 117060 gtgcctggag tgatgtttaa gccaatgtca gggcaaggca acagtccctg gccgtcctcc 117120 agcacctttg taatgcatat gagctcggga gaccagtact taaagttgga ggcccgggag 117180 cccaggagct ggcggagggc gttcgtcctg ggactgcact tgctcccgtc gggtcgcccg 117240 gcttcaccgg acccgcaggc tcccggggca gggccggggc cagagctcgc gtgtcggcgg 117300 gacatgcgct gcgtcgcctc taacctcggg ctgtgctctt tttccaggtg gcccgccggt 117360 ttctgagcct tctgccctgc ggggacacgg tctgcaccct gcccgcggcc acggaccatg 117420 accatgaccc tccacaccaa agcatctggg atggccctac tgcatcagat ccaagggaac 117480 gagctggagc ccctgaaccg tccgcagctc aagatccccc tggagcggcc cctgggcgag 117540 gtgtacctgg acagcagcaa gcccgccgtg tacaactacc ccgagggcgc cgcctacgag 117600 ttcaacgccg cggccgccgc caacgcgcag gtctacggtc agaccggcct cccctacggc 117660 cccgggtctg aggctgcggc gttcggctcc aacggcctgg ggggtttccc cccactcaac 117720 agcgtgtctc cgagcccgct gatgctactg cacccgccgc cgcagctgtc gcctttcctg 117780 cagccccacg gccagcaggt gccctactac ctggagaacg agcccagcgg ctacacggtg 117840 cgcgaggccg gcccgccggc attctacagg tacccgcgcc cgcgccgccc gtcggggtgg 117900 ccgccgcgcc cggcaggagg gagggaggga gggagggaga agggagagcc tagggagctg 117960 cgggagccgc gggacgcgcg acccgagggt gcgcgcaggg agcccggggc gcgcggccca 118020 gcccgggggt tctgcgtgca gcccgcgctg cgttcagagt caagttctct cgccgggcag 118080 ctgaaaaaaa cgtactctcc acccacttac cgtccgtgcg agaggcagac ccgaaagccc 118140 gggcttccta acaaaacaca cgttggaaaa ccagacaaag cagcagttat ttgtggggga 118200 aaacacctcc aggcaaataa acacggggcg ctttgagtca cttgggaagg tctcgctctt 118260 ggcatttaaa gttgggggtg tttggagtta gcagagctca gcagagtttt atttatcctt 118320 ttaatgtttt tgtttaatgt gctccccaaa tttcctttca tctagactat ttgattggaa 118380 atatgtcagc tatgatgatg actttctggg aagcgattcc tgtcacccgc tttcccctcc 118440 tccccacccc acgtcctggg gctttagaga gcgattggga gttgaatggg tctgatttcg 118500 gagttagctg gctgagtccg cgctggagcg gattgctggc atgtgacttc tgacagccgg 118560 aaatttgtag gtgtcccgcg agtttaaaac aagccatatg gaagcacaag tgcttaaaaa 118620 taatctcctg ccagcccagt gacaagcctg tcccacccgg ggagaatgcc ccggagtggc 118680 gtgcgggtca gccagggtct gcgcctcgca gccactgtgg aaggagcgcg gccggtccag 118740 gacacaggag accactttgt gacttcaatg gcgaaggttg tgtgtcctca ttttaatttt 118800 tttccctaca agaattgttc tttctccctc tcctctccct cccattttct cttgcccagt 118860 ttctcctttt gttttttgtt ttttgttttc ctgatgggcc tgcagaggga ttaggtgggc 118920 gcttctggtg aacaccttcc taggtggcca caggacaggt gtaccccgga ctgggtttgg 118980 aagcttcagg gcgccacatg gctgggtcct gaattaggca tttcccaact gtacactggt 119040 atccggactg gtgtccctat atctttctgc cttgtaagcc gtggaccagt ttttgttcag 119100 tattctgttt ccagggatat ttatagcaga aggaagggga ctaaagtgca gtttggcccc 119160 agaggatact gaagggcaga ttctgggggt attcagtgtg catcttcagc cgccttggag 119220 aaatttagag catcccacag ccacgcagat ccaagctgtc tttactcaaa agacaaacaa 119280 tgaacaaaac ttttaaaggt tggcatattt caaattaatt ttacttgttt taatttaggg 119340 ttaaaacaga gaaaaaggat ttcttctgcc cacctttttt tttttaaatg gaagaacaaa 119400 gtacagcgat taagtctaat tccacacaac atttaaaact gcttgatgtg aaggaaggca 119460 ctggtatgat gtgaattcca taaccttatg atggactcca gaaaccattt tcttccctat 119520 ttaattttca gttcttttat tgcaaattaa tgctgctgaa tttcaatggg cactaatgag 119580 actgctcctt ggtagattat ttactgcctt gctaataatt acaaagtgaa cctggtcaaa 119640 tacagagggg atcgcatctt attcaaaatt gttcatcatc ccagtgataa gtggtatcag 119700 tgtaatatgc cctatcttac actttctgca ttacatgata ttcaaacact cttagaataa 119760 taaaaaaaga gacaaggaac ttaaaaatta aaaaaaaaac ttgcacaaat gggactctgt 119820 gtggaaattc agttttagaa tgatttttcc tgtgttttat ttcccggatt atctttcctc 119880 ttttgttaga attctgcctg ttattatcca gcaaggaaaa gaagcatcta tgcaagttct 119940 tcatatggac agatattatt tagtattttt cccctctcag tttttctgct taaatgactc 120000 tgggtataaa ggaaaggatt gattgggctc ttttaggaaa ctttaagttt cttaagtagt 120060 tctcaaaagt tttggggctg aaagcagtgt tttcaaactg cttgtcatga cccagagggt 120120 catgaactca gtttagtgag tctagaatat tttttaaaag gactaaaatg gaaaggaata 120180 taatagaaaa tatcagagtg catggtattt cgtaaggata agttttgttt cctgaaaatc 120240 tgttttaatt atatgtgctt ctgtgtgctg attgtgatgt aaaatgtatt tcttactgtg 120300 gattgaattc aaagaaaaaa ttagaaagct aatggcctaa aatattatat gttcagtaga 120360 aaacaaaaaa ttcaggcaag tggctggttg tttttaccta tacaaatcaa aaggctattt 120420 tgattgtctt cattttcccc ttataaatta ggttggtgtc tttagtcatt taggctaagt 120480 tttactatct gattcttaac ttttctattg tagaatggtg ctgtcatgtg gactgtcctc 120540 ccgagtgtcc cactggatgt tcagagaatt tatgtgaagg tcacgtcatt tagcattgag 120600 atgctgtggt taccttcttc catttcttcc ataatatgca gccacatcta tgtgtgaaga 120660 aatgtaatag ataaaatttc tctggacgca taataatgtg agaaagattg tcacatgtcc 120720 cagcaaattg ttattaatat aaatttgtta cttggcaagc tgagattttg caagatgtta 120780 ctcaaaattt cacaatgaag gaaacaggga gtcatcttat cctgggttcc ttttttagat 120840 ttcaaacaac ttaggaactt tgaataaaac taaagatgaa gcttaactat atcaactatc 120900 ctttttaaag ttctaattag gaatttaatg ctgcatgctt atttcagttt tattactcag 120960 tattcttaaa agttagacgt ctctcacttc tccaaaaaac ttggcaaatg tataaatctt 121020 ttgcatcaaa atcaatgccc tgctaatttg tatcctggcc atctgcatat tttggacaac 121080 taatttttcc actggtgatc atttgaaact ctttctcaac tttgaataga gactgatttc 121140 caaagtgaga tttaagtgac taagtttcaa gtttccgata catttttcct tttacttaga 121200 taacatttca gcccccttcc tttctgatct tactttttta ttaatttaaa ttgttactga 121260 ttacgtgaca ctttgtgctg gtctaagaat agtccagagt cacatattcc ctggtgaatg 121320 agcatatttt cggatgaaaa cggaatcaca tcttcaatcc ccatttcatt ttcacctcct 121380 ccatgtggct tgtacctgtt tggaagaaag ctcctgaagg ataattgcca cttattctaa 121440 tctttctcac actcatttaa tttggatccc tggctaaagt tgttatttac ttttgtgatt 121500 atacttagtc tatgacattc ataatttggg aaaattctca ggtttgagaa ttttggcggc 121560 ttgggatttc ttttagtttc ttatagtttt aaggatatgt aagacaggtg taagaaactg 121620 ccaaggggag gaaccataga tatcaggaaa aactagaaaa gatgccagac ttaccattaa 121680 tgaatgatga gacaatagta actttgttaa gtgagattgt atatgtgaaa gtggtataga 121740 aactaaacaa acattaggtg tttttattat tttactcaca tgttaatatt tgttttggtg 121800 ctttcatagg ctaaaaagct gggaaataac agatttaagt ggtcaggaat tttgttataa 121860 atatagaatg atgattatat gaaatctttt cctgtgaaag tcaaatttaa gtaaaatctt 121920 tatcaccatc tgcaacattt gtctgcagcc tggcttacca ggttatcata aagaacattt 121980 attttacaga tacattaaag aaagtcaaaa ccctgattat gtgtaaacaa ttttacataa 122040 ggaaatatat gaattttaat tatatttttc taaaatccgt actcagcatg aaattaatac 122100 atcttaaccc ctccctgtga cttcattatt atttttaatg taactttaga agaacccagt 122160 agagagagca gcgtgctaag tgtgtttctt tcttttccag acaactttga atggagagga 122220 gcaaattagt cttttggttt aattctgtct cagtttgctt atctaaagaa aggaaaacag 122280 agtggctaca cttgtttaga accatatgca tactccagag aaagatgctc tattaatcca 122340 aaaaatacag ccacttgaaa ccagccaaag cgaaagtgta agggacttca tggaaaggag 122400 gcagttcacc aaagttattg aggggtttta tattttaaac tccgccagtg aattgacgtg 122460 taatgtcact tacaaaaaaa aaaaaagtat gtctgagctg ttcgctactt cgtctctaaa 122520 atatactcat actgatctct gaaatcccag aatttaagtg ggctggaggt tacgggaagc 122580 acctttataa tatccttaat ctcatgaggg aagaaaccat aattgctgaa ttctctgcct 122640 tggataatat caggagggac tctgaagaaa gttttgcagt aatcaacaat gttttaaatt 122700 atgtgtatat ttttagatca cctcaaaaaa tataggaagc acagaatgac aactattctg 122760 gtctcaactg acacaatttt atgtagttta ataaagtaat aatttcaaga aacgtgggca 122820 aataagaaag agtatgactt tcttacaacc cgcttgtaag tgatgtggtg gtggtaatga 122880 tccatgattt tgatgatgac gatgatgatg aaaatgaagt ttttgtctca gtttgggtag 122940 gtggtatttc tggatgcctc ctatggaccc tggagatgtt catcctatac agaaatccaa 123000 tcctttaaat ctacttggct cattgtttta gaattctaat tccatagtct gaaaatttta 123060 ataatgatat taccaataat attagaaact tattaagtac ctataattgc tatacaaaaa 123120 atttaaaaga acccaaaatt ccaagcaaga ctgaaaattt tttgtctctc ctctgaacta 123180 tttagaggga caaattagtt tgttcttata atatctactt taaataaatg tgccatcttt 123240 aataagatag tagacttctt tgtttggtaa tgttctattt tttggagatc ctatgagtta 123300 cacttgggaa aattataaaa gttcacttaa agttaataaa atccattaag taatgttcag 123360 aactagacat ttccaaatga gcccttgaaa agctcaggtg ggttcttttt gagagttccc 123420 caaatgttgt caaccccagg aggaatggaa gacctctgca gttttgttat tcagattctc 123480 atctccttct cagaagccgt agaactggcc gggccctaag gtccacgctc cttggttcca 123540 gttctgtctt ccatccttcg gtcccgggct cattctgcct gttcctaaac ggtggcaagt 123600 taggggcccc agcagccaac ttgtgcttac ctggcactac ttcctgggca gttttcttgg 123660 ctccttgact tgttgggcgg cttgggattt cttttatggc cctgaaagca aaagacaatg 123720 ttctctttta gtttcctgca attaaatgat gttagaaata gtcatcttca cattggcgta 123780 cttcctcttt cttctgtagg tcttttagaa ttttgagtcc attctcatat tttcttgttt 123840 catttgcttt attttctaat acatagaagt ttaaactccc tttaaagagt ttttggcctc 123900 ttttacccta ttaagctttc ttttttcttt tctgttttag ttgttccatc tgtgtattct 123960 cagatatttt tctttcacct tttctggttt atttctttat tgacctgtct catctgttat 124020 tttaatgaaa tttggaacag ggctaaacag agttcctacc tcagccagta taagaatata 124080 ccgtaataac tcagagtggt attaactaga ttaaaagttt caaaaagtga tgtttttctt 124140 gtctctgagg atagaaactt caacaaaata aagaagaaat tttcaattag tagaatttct 124200 ttgaaagttt gttcattcat tcatttggct accttattcc aaattgagtc attcattgag 124260 ggcttagact atataaagtg tggttttgtt ttcccagcag ttcatgcaac agcattgcac 124320 ctagcagctg ggaagtctta tagcatgaat aggtgagatt ctaataccag aatctcctgc 124380 atgtgtaaac taacagtgta gtcttgactg ttgtctccca gtaaacttgg tttcaggagt 124440 tttagatcca tgtgaacgtg tacaaggcat ttttgctaac tgtaacttcc cacttaatca 124500 acaaaaacaa aaacactcat ttctgaacat tcagtgcatt catgattaat cttaattaca 124560 ccacaaaggt atttttcaat ggtgattttg cgggagtggg gtaacagttt cgaaagcaac 124620 attgtcagaa acatagttga ttttaaaggt tctttctggt gactttgact tctgcttttt 124680 tagaagacct tacacagagt tgtatttatt tctcctggaa tatttcaagc aattcagagt 124740 gaaagggtat acattccaat ttgcgtatga gataaaattt agttacattg agaagctatt 124800 ttctttagtt acagggaaaa aattgtaggg cttttggaag cctctttgat ttctaatagg 124860 aggaatccct gagcactggt ccaaacagaa atcatctctt cttcattgct gtatttccct 124920 caagctctta gcaaagtgca tggcacgtga aagcccggag aagctgttgg ttgaaagaat 124980 ggatggtggt gggcaggaag catcagggac atggtttgct tcagtctatt ggctgggaga 125040 aaggccattt aggaagggat ccttagatgc cactggaaga atgtgggaag tttgtgaatc 125100 tctctttctc aggaacaaaa gtagaaaaag gactccacac agcattccaa gtacagtcgg 125160 ccctcattat tcatggattc tgtatttgca aattcgctga cttactgacg tttatttgta 125220 accttcgagt caacactcac ggtgctttct cagtcctttg cagacgtgtg gaatggcaaa 125280 aaaatttgag ttatatgacg tatatgttcc cagctgaggc tgagcaaggc tcacttctcc 125340 ttgcagccct cagactataa acaagtgtcc ctcttgctat ctacttcgtg ttatgatttt 125400 tgcattttca taatccctgt tgatgatttt gctgtttaaa atggccccta agcatggtcc 125460 tgaagtactg tctagggatt ctaagacaag gctctgacgt gtcttaagag aaaatacgtg 125520 tttgataagc tttattcagg catgagttac aatgctgttg gccatgagtt caatgatggt 125580 gaatcaacag gatatattaa atacagtgtt tttgaacaga aaaacatata aaacaaggtt 125640 atgtattaat gagttggcaa aaatgctgtg accaaaggct cccaggaacc taccctattt 125700 tcccctcaat gcaatggttc agtatttgct aattcagtgt ttgaggtgac tttatagaac 125760 atgagtacca tgaataatga gaatcgattc tgtataatag agtgatgaaa gcacaggtct 125820 gggagccagc agctatattt ctattctggc gtgactcctg tgtagttgtc atcactggca 125880 aattgcttaa ctgtgtgcct cagtttccta atctgtaaaa gctacatcgt ttggatgatg 125940 tgaggattaa acaaattcat agatgtctag ggcttataac attcctggca cataacaagt 126000 cattattttt tattactact tcggaaggga attgagtact ataccctgaa gaaggtgagt 126060 atgggaattc tctacgggtc tggaatgtcc ctatatttgt ttattttgcc ttcaagtgac 126120 taactttaat accctattgt gattagaagt taaacttctg caaccaaaag gaagcaggaa 126180 gctagtattt cttgaagtgc ttattacatg ccaggtactg tgctacaaaa acaaaacaaa 126240 acaactgtaa aaaaaacttc aaatttggct gcgtgcagct gctcatgcct gtcatcccag 126300 cactttgagg aactgaaggg aggattgctt gagtccagga gttccagacc agcctgggca 126360 acacagtgag accctgtctc tacaaaaaaa caaaaacaaa aacaaaggca ctccaaatca 126420 gtaaaaatta atcaatcaat aaaaagagtg aggggcatta agtattgtgg actgaagcaa 126480 tcccagagag ggaattaatt gaagctgagg taagcagctt atggagaagc tatgatgtac 126540 agagggcaag gaaggaattt ttctgtaatt tggaaaaatg ggaactgtga gaaagaagga 126600 gttggaagct catacttagg gagcatctac aaggacgtct ttttcacgtt ggttggaata 126660 tccaaatcaa ggattatttc agaatcaccc agatgattaa aaaactactg agatccaggt 126720 tgtatttcag cagttctgac aattgctctg ggtcgaagct tgaatcagta gttaagaaaa 126780 acaacaaaca aaacaaattt tggggctttt ctcactgatt tacagttaaa gctcatttac 126840 tcttcctatg actttagatg gaggatattt ccaagtcttc aggatggaga catggaggga 126900 agtgagacta gtgatgtgcc tcaaggtttt gctgttgttc taaccatgag gagcactatt 126960 caaacccagg tctgctagat ttccaagtct tcatttcctt gggcctcttg gatttcagaa 127020 gcagagggta aaaggagtgc tggggagaaa gatcacagta gctttcaatt ctactcctca 127080 gctttccaaa ataagtttca agactggccg ttgcatttga tatggaataa atacaaagaa 127140 ggtagattga agggtatgaa gatgcagatt tttgatacca gatatgaaga taacattagg 127200 aagcaatcta aaacatggac acaaacacac acctgtgcca gttagcctgt ataattcgat 127260 ttttgttaag tgtttagata actgaaggta atttaagccc tcatatcttc ccttcatagg 127320 gttctttttc cctctggttc atcagagagt tgccaccaat tcaggctgtt agtggtacac 127380 ataacctcta gcattgttga tacagctata aaatcccaaa tatcagtaca attgttgatt 127440 gcataaaatt tccagttgca tggttggaaa gtcctgtaag tttgaatcct taaaccagtc 127500 ttaaatgtgg aggaggactc aattaaagct ctcctcgtgt cctccctctg acgtatttgc 127560 aaaatccttt ccacaaatag aatactgttt ttaatgcttc cccagtccaa ttttgcgttg 127620 tagaagacga atttatggat gagggaagtg gcattcaggc actccagctt ggtatagaag 127680 cccatggtgt ctggtcctca gtcctcaagc ccgctcattt cctcatgtga actcagaata 127740 agcagctgaa agcaagtctt caaaatctca gagatatgta taaatgcaag tgtttgggtg 127800 agaagtgaac atgggtctcc tctagtgccc acactacttg actaacaggt tttgggctcc 127860 acacaatgag ggattatcaa cccctgtccc agggctctct gggtcttggt tctttgtttt 127920 tgatgctcag caattgtgat cagtgaaacc aatgttgctt ttctatcaag agtccaaccc 127980 ttttctaaga agggttgtgt ttgatattag ggaatagcta gcaaagttat caagtaactt 128040 gtagaaacat tcttttgcaa gagttcttat actgaatgac tgtagttgac agcagtgcag 128100 tactggtcat tttctaggac atcttaaaaa cactgatgag aagtttcctc tcagatgtct 128160 gtcatgtcat tcttgccttt ctctacacag ggtcagtttt ctcttattgc tgttaggagt 128220 tcctcattgg tttttcagct tttgggcttt caaactctaa ttaatcataa gctactagag 128280 tgtactacct aaagtgtgta tatacacata tatacacaca cacacacaca tatatatacc 128340 tggtatacat atatatatat aatatacata tatcatatat actccccaac ctgatctggt 128400 tcttcctctg cataaaagac ctcaggccag tcagagaaaa catgtatgtt ccatggtgtg 128460 gcaatcaagc ccttgtattt ggttccaatc agtctcctaa ctattactcc aagaagctct 128520 tgttgaaaga gccatgttta aatggcatgt tcctactttc ttcttcatag tgatcttcat 128580 ctgtaccatg tacccttctt tcttcttgtt ccatctctgt taggctgatt ctacccagaa 128640 gtcaaggttc agctcaaatg ctatccctat caggtgaatt ttccacctgg catttgttcg 128700 gtgtgcattg tgtgcataca gcaccttttc ccggtacctt tactgtaatc accagataat 128760 tcctttcatt ttagttgtaa atagagttgt cttccccctc tatggaatag attttattaa 128820 tgtatagagc agcagtcccc agcctctgga ccatggactc gtactggttt ggggcctgtt 128880 aggaactggg ccgcacagca ggaggtgagc agtgggcatg caagtgatgc ttcatctgta 128940 tttacagctg ctccccatcg cttgcattat gcctgagctc cgcctcctgt cagatcagcg 129000 gtagcattag attttcatag gaatgcaaac cctactgtga actgtgtatg tgagggatct 129060 gggttcttct tatgagaatc taattcctga tgatctgtca ttgtgtccca tcacccccag 129120 atgggactgt ctagttgcag gaaaacaagt tcagggctct cactgaatct acattatggt 129180 gagttgcata attatttcat tatatgttac agtataatac taatagaaat aaagtgcgca 129240 ataaatgtga tgcactggaa tcatcccaaa accatcccca gttccatctg tggaaaaatt 129300 gtcttccatg aaaccggtca tggaactggt gccaaaaatg ttggggacca ctcttataag 129360 gcatattaga gtaatttcat agatttccta attcatttat catattcatt cactcagcaa 129420 gcattactgg atgttgatca tgtactggct ttggtggtag gtgcagagat tgggaacatt 129480 gtcatcaagg agtttatggt tgagtgaggg agatgacaag tggatagaca atgaaaaaac 129540 agtagaataa gaactgtgat agaaaagaga cagccaggag cattgaggag aggcacttaa 129600 ccagatggag gatcttggtc cattgatatg gaggtcaaaa tggtttaata gagcaagtga 129660 ccctttcaac tgaatttttt aagaatgagg atttagccag acaaagaagg gcaggtgagg 129720 ttgtgaagag gaactgagtg gtactcttca gagctccagc ccagttcctt ggacagaata 129780 aatgcttact aacttataga gctgaatatt gaattaataa aataagggta aactgttaag 129840 aatcagagaa ataacttaaa gaacactgat agctagtgtt ttttgaacac catgtaccca 129900 ggtgccttgc cgaaaacctt aatgatcatc ttgtttaaac cttacatttc tcataagagg 129960 ctggtactat tgttattctc attttatggg acgtagaaac taagacttgg agaggggaag 130020 tgacttgccc aaggtcatac aaccagtact ggagaattag ggattctaga tctagaattt 130080 ggactctgga gcttaaggtt ttaacccacg acattatgca gagaaattga caggattttt 130140 ctgttgctga tcaatttact tggcagttag tttgttactt ccttgtcttt attttagttg 130200 tgacaatgct ttcatcttag actgtgtccc gaggctgctg cttttatttt tatgggaaat 130260 ggctattttt atgatccttg ctaaaagcat gtttaaacaa ttttccatta agtaggggga 130320 tgtttttcct tctaatatca gaagccaata aatgaaattc tacaaagact tgctggtagc 130380 aaccttagga atttctttgc atgtgaaacc catctgagaa cttaaaatct gggtaaaatt 130440 gtagtgtaat ttggtgcaat cgtctctttg cacaaataac atcataaaat catagtattg 130500 tcatctagga ggggccttag acatgatgga atcctacctt ttatattttc caggtgaaga 130560 aatcaaagtc tagaaaggtg aaggaacttc ccccaaagtt tcccagctgg tagagacaga 130620 accagggcta ggtcctctat tctgactcct gaccactacc tcacacctaa tagatggagg 130680 catgcccagt tcctgttcac cgagggcatc agaccatgcc atactcattg ctactgttcc 130740 agcatttata gtagaagctc aagcaagcag gatgacagaa tacctaattc tggtcactac 130800 aacattataa tgatggctaa agtgaatgcc ccagccatgc ttgtctagac aggccatctg 130860 tttaattggt atatggttca cgtgagaatt tttaacctct gtttgtcgag tcggtgttag 130920 ttctctagtg atgaattatt tcctatactt ccatttagat tatttactct taatttaata 130980 accatacatt gtttactttg gtattgaaga ttcccttgtt tttcttcttt ttttctgttt 131040 ccagggctta aaggttagga gtgaccttgc cagacttccc tggagactta cactgtctcc 131100 tttcagattt ctgaagcagt tgggtgctat ttttagtcca ctatcaccaa tgtgaaaatg 131160 gaacttgcat tatttcatta tagatatttc actttagtat tgacagaatt aaaaaaataa 131220 tttgatctgt gcttgatcta gcagccaggt tacaatagac atttttagtt acctggtcca 131280 catgttgaaa aacatgtgtc ttctctgaga ctaatgacta agcccgatgt tggttatata 131340 ctgtttacta ttaaattttc cccttgtagt ttaatattgt tccaggaaat gaaatgaaag 131400 tttaataaga atggcaattg atggacccat atgtcggaag tataactaat gtccccgtta 131460 catgtgttaa agaaaggcat ggctggtggg ttgtaactgt actacaccaa gatgatttga 131520 cacaacttat tctacagaga tatatattta tcaggataga atttataact aaacaaaact 131580 atagcatttt ttcactttga ttttttttaa atgagtcaaa gaactgctag aattgtcagt 131640 taaaaaattt taaaaggaga tatgaaaaaa tcttacaatt cacaatgctg taaagagata 131700 atgtagggat taatatgttc ttgatatcaa tattttatga cttttataca tgtagaagca 131760 aaacaatttg aggtaggtga agttagtatg gacttcttga gattgtcctt cacatttctt 131820 ttcctttcgg tgaaaaattg aaggccaaaa tgtattttct tctggttttg aaaatactgt 131880 caagatcctt gcaacaaaat gagttcctct aaggagctga aaacaaagct cactcccctc 131940 gtgatactct gagaggcttt gctcagcatc ctgcattctg gtgattcctt ggagacagat 132000 gatgctaaac acaggaagat taggtcaatg gtaacttttt ctaagtcaat atttcttctc 132060 cttgggagat gatcatttta aatcttcccg aagtccaggc taaacctttc taattgaatc 132120 tccatgaagg agagctccag caggtggaga ggaagtgaga aagagaaatg aaagctgcac 132180 gcctcatgac gctgtgccag ggagttctta aaggtgaggg agtttctttt tggtaaccta 132240 agctatgtga atcagaaggt tcattagctt gtttcttttt cttttttgta aactcctaca 132300 taattttagt aaacaggaac agtaacctaa tgtgatatcc cactggccca agacttagtg 132360 catcttcaaa gttgcttaat tatgtccgaa acagactttt gtctcttgat gagaaaagca 132420 tggttaaacg tgtgatgatt tcctattgtc ctgagctcag atctgtaatt gtggccagat 132480 tcatgcatct ctgctgcctt ctcttagaag aatcatatgt aggcttgtca gataaaacag 132540 gatgcccagg taaactggaa tttcagttaa ataacaaata acattttagc atgtcccatg 132600 caatattata ctaaaatatt atttgttgtt tatctgaaat tcaaatttaa ttgaatgtcc 132660 tgtatttttg ttggttacat ctggcagccc tagccatgct gcctttctgc ttaatgggct 132720 taattttttg aaggctggag gttttctgtt atggtgcccg tttccacctg cttttctacc 132780 aggaaaggag gcatgctgat gtagaatttg catccttatt tttgtcatta ttattgatta 132840 taacagatga cataggttta gattaaacct acaatgacat tgctgtcatt cagataattg 132900 taattattgc taattgtaaa gaaggataat tttttttgaa atgactatta tttgtttttt 132960 gtttttgttt ttgtttttct ttttttctaa ttatacttta aattctaggg tacatgtgca 133020 caatgtgcag gtttgttaca tatgtataca tgtgccatgt tggtgtgctg cacctattaa 133080 ctcatccttt acattaggta tatctcctaa tgctatccct cccccctacc cccaccccac 133140 gacaggtccc ggagtgtgat gttccccacc ctgtgtccaa ctgttctcat tgttcaattc 133200 ccacctatga gtgagaacat gcggtgtttg gttttttgtc cttgggatag tttgctgaga 133260 atgatggttt ccagcttcat ccatgtccct acaaagaaca tgaactcatc cttttttatg 133320 gctgcatagt attccatggt gtatatgtgc cacattttct taatccagtc tatcattgat 133380 ggatgtttgg gttggttcca agtctttgtt attgtgtata gtgccacaat aaacatacat 133440 gtgcatgtgt ctttatagca gcatgattta taatcctttg ggtatatacc cagtaatggg 133500 atggctgggt caaatggtat ttctagttct agatccctga ggaatcgcca cactgacttc 133560 cacaatggtt gaactagttt acagtcccac caacagtgta aaagtgttcc tgtttctcca 133620 catcctctcc agcacctgtt gtttcctgac tttttaatga ttgccattct aactggtgtg 133680 agatgatatc tcattgtggt tttgatttgc atttctctga tggccagtga tgatgagcat 133740 tttttcatgt gtctgttggc tgcataaatg tcttcttttc agaagtgtct gttcatatcc 133800 ttcgcccact tgttgatggg gttgttgttt tttttcttgt aaatttgttt gagttctttg 133860 tagattctgg atattagccc tttatcagat gagtagattg caaaaatttt ctcccatttt 133920 gtaggttgcc tgttcactct gacggtagtt tcttttgctg tgcagaagct ctttcgttta 133980 attagatccc atttgtcaat tttggctttt gttgccattg cttttggtgc tttggacatg 134040 aagtccttgc ccatacctat gtcctgaatg gtattgcctg ggttttcttc tagggttttt 134100 atggttttag gtctaacatt taagaagaag gatacttaaa gtataaggga aaatgttaca 134160 atgtatgaag ggaacatgaa gaaatagaat ctggtaaaaa agagttcttg cttttgggag 134220 gccaaggcct cctggctaac atgatgaaac ctcatctcta ctaaaaatac aaaaaattag 134280 ccgggcgtgg tggcacacgc ctgcagtccc agctgcttgg gaggctgagg caggagaacc 134340 acttgaaccc aggaggtgta ggttgcagtg agccaagctt gcaccactgc actccaggct 134400 gggcaacaga gcgagactcc atctcaaaaa aaaaaagaaa aaaaagagtt cttgctttca 134460 aaactatgga ttaggtaact tttgtgaatg agtaagatca tgagtattat aaaaatagca 134520 cctttctttt ttgtcttggg gaaattatct tattttttaa ttggatttca gaaaagagta 134580 tttcagagaa ataaatctct gaaatgcttt ttgaagtgtg aaagatttag aagacaaaag 134640 caaacctcct gtctagataa acattaaaga gatctgccct cccctcctct acctattcag 134700 gttgcaacac tttgggggtg gctgccttgg tagagcttga tcgtgactct ggtggcttgg 134760 gagatggcat gctgcacaag ggattcatgg ttacagcggg cttgtgggac tggggctctc 134820 caatacgtgg ttgggtttgt aaagaaatca gagctatggt gtgaacaaaa ggatatgcat 134880 gggagacagt gagacaagga aatgctccag aaattattgg aatataggtc agataactaa 134940 ctgtacttgt gccattttct gggggaaaat tctctgaagg ctttttggga aaagaatgga 135000 agtgagaatt ctcaggtcct caaaatattt ccttttactc agtcctaacc tgaggccgtt 135060 aaagaattcc cagagtcacg atggaaggca tgtttgggag taagagccag agtgagggtt 135120 agaaatgtgt tgttggccag gtatggtgga tcatgcctgt aatcccagca ctttgggagg 135180 ccaaggcagg tggaccacct gaggtcagga gtttgagacc agcctggcca aaatggagaa 135240 acctcgtctc taccaaaaat acaaaaatta gccaagtgtg gtgacacgtg cctgtaatcg 135300 agctcttcgg gaggctgaga caggagaatc acttggaccc aggaggtgga ggttgcagtg 135360 agccaagatc atgccactgc actccagcct gggtggcaga gcaagactcc atctcaaaaa 135420 aaaaaaaaaa aaaaaagaaa gaaatgtgtt ttccagggtt ctgggtactt aggaatttgg 135480 ttgcttttgc aggtggaagt ggaggtgact aggtaacagc tgagtgattt tgccccagtt 135540 ggacatgagc caggttgagc agaaagccct gggatgcggg gaggggggtg gcggggaagg 135600 aattgaaagt tggttgtgtg gtttggcttt ggcttcatgg catgctcaca ccttgcttcg 135660 catagcatgc ttagactaca gcaggagcat caggaagtgg atttctgagc tcaatacaaa 135720 aagttataaa taccacctat aagggcaata aagatatata gttgattttc ttctttgcaa 135780 ggccaaatct tataggaaca taagagcgaa tgagttacag cctgggaatt tgagccttat 135840 attcagagat tttaggttgc ttctgattcc gctgtctaga caaaaccatg agaggatagt 135900 gtctagaaat gagaggaagc tcttccaatg cagaggctag aatgtgtcag cctgtgctgc 135960 gaggcctggg atagatgttt ctgaaaagta aaagggcagc tttcctactg gatacttgat 136020 cctcaggctc tagaaaactc tgctttatta actttgttga cttcctaggc accacatggg 136080 atccttgttc ttcctccttg taagcagtaa ttgaaatcag tttggcagcc tggtttacag 136140 tgaccatggt ggcttgtctc ccgtgctctt acctcactct gttgatgttg taaaacctcc 136200 agctaacttc atggggtggc tgacccacgt tgctcattta ttcattcaac acatattcat 136260 tgaccatcta ctctatgcca ggtattgtta tcagcactgg gaatagatca gtgaactatt 136320 gatctatttg tctaatggga caaattgaca aattgggaaa gattccatta cacaggtgac 136380 atttaagcaa agtcttgaat aagggaggga atagtaccat gagatatcct ggtgaaaagc 136440 aatttaggct gagggcacag cagggaagag gccctgatgt gggaacatcc ctggtgtctt 136500 gaggtacaga ggccagcatg gctggcacgg agtaagaagt tggaggtgcc gggcatggtg 136560 actcacacct gtaatcccag cactttgggt ggctgaggca gatgggtcac ctgagcccag 136620 gagcttgaga ccagcctggg caacatggtg agaccccatc tctacaaaaa aatacaaaga 136680 aaattagcca gatgtggtag catgcatctg tagtcccaat tgcttgggag gctgagatgg 136740 gaggatcaaa ttacttggga ggctgagatg ggaggatcac ttgagtccag gaggtggagg 136800 ttgcagtgag ctgagatcat gtcagggtga cagagcgaga ccctgtctca aaaaaaaaaa 136860 aaaagaaaaa gaaaaaagaa aaaaaaagaa gttggaggtg agtaaggaga ggaacgtggg 136920 ggacagagtc ctcaggactc tggcttttac tctgagtgag tcgaaaatcc aattaaaggt 136980 ttgaaagaga ggaatgacct gatctgacat tttattgtga acgttttcaa atctttacag 137040 aagtggaaga gcataacgat ccttcatgta cacatcgccc agcttcaact atgatgtttc 137100 atttgtaaat atttccgtct acacttccaa aggatgatga ctatttttaa aagtccaact 137160 ataataccat tatattttaa aagttaaaac actatgtctt taaatatcaa gagtttgtat 137220 tgattcgcac tttgaaggtc gagctgatga aatttcctga ggggttggat gtgacatgag 137280 agaggagtca agtattgcat ggtaattaaa aacctttgca gcatagtcca tttaccgaaa 137340 gactatatgt atgcacttca aagcaggttt taaagattaa catcaagcat ctggcttcat 137400 gagttttaac ttcttttcat aaatgttata caatgtcatc atctctccag ctagagaaaa 137460 tgctattatt cttattttca aatgaggaaa atgacgcaga attatttaca tattatgtaa 137520 cttggtccca agtcccttag atactggttt agaaaatcct agtaaactgg aagtgactta 137580 tccaaaatta aaatttattt tgctctattg tcttttgttg cctatgggaa ctttgtgcag 137640 gtaactaggc acatgtcagg actgatttac tgacctctca aggtatcttt aattattttg 137700 ggggatatca cggaatgagt tctacacaat tcatttgaat cgaattgaac ttaagaaaat 137760 tcaaatgatg cattggctgc ctcctattta ttacatgctg ctcataggca taacagcata 137820 gtctaacaag tataaaacct gtgtaactgt agctttcagt gcagtgtgat gagggctgag 137880 aagatagtgg tacaaagaag agaggtagca gagtgaagct gagtcaatat gatgaagatt 137940 tctctagact tgaaagggct agaaaaggtt attcttggca ggaaaaaaac atgagccaag 138000 gcataaggat aagcacaggc atggcagatt tgggaatgtc atgtaatttg ttgctgggct 138060 gcaaagtaca tggaagggga gtgaaggaac agaaggagat gaatctggag ggagaggtta 138120 aagtgttcca gagagcaata tgtaggtgtt actctaagtc aaagaggtcg taatagcatg 138180 tccagactcc aaaactctaa acaagtcata gaattgctgc cttggtaggg catatcacac 138240 acatcaaccc aatcctctgt caccatgaca tccatataac tgcaactcta tacatttccc 138300 agcctatgtt cccagagtct ccagatgaca ttgtctgcaa actgcactgc agaaggctct 138360 gctatgtctt cttaaaagta agcaagactg ttttcctttg ttacatgagc agcaaaagga 138420 tagggtgctc tttgacctca cttactgtag ggtggatagg aaagtcaagg aagagtaacc 138480 cagaagattt agttttaact ttcgcatcaa agaggtccct tagcatctgc tcagagatgt 138540 cacaatttct ggtgtgtgat tatgtttaag aattcggcct tgccactgtt gaagttgttc 138600 tgtggaaaaa gaacctctct taattttaca tgatgcccaa cttctctttt attccagaat 138660 cactcatatg ctgttggact ctttccagcc atgtgtgcta acctaggcaa tgtcataata 138720 gatgaattat gtttactttg tctttgatat ctcagctctt ttatcttcta ttcaagttcc 138780 cacctccatc attactgata gtgttcgttg aacaaagaat atgtcagata tacagaagtg 138840 tttctcccct tttctctgtc tctcttttcc ttcctttcct ttagtttcct ttctctgtct 138900 gttttctgat gcctcatttt agaaaagtga ttttttttgt gggaaaatca ttttagcatt 138960 agaaacgcaa tggctatcac tgacagcttc ctctgatgaa acggccattt gtcatcatta 139020 cacggtcatg ggagtgctaa gaagacttaa atgcagggct accacccctt cccaattcat 139080 cttttatcca ttttatttct ctaaggaaag ggtttgaaaa atgggctttg ccctcttgga 139140 tgcagtgaag aaattctagc tggctacaga tgttattgtt ggtcggaggc aagggataaa 139200 atcatggtca caccattgta gcgccagatg gggaatgtag caaacatagt tgtaatttct 139260 cattttacag atgaagaaac tgaggtgcag aggggttcgg tgacttgttt aaggcatgta 139320 attgttattg gcagctttct gttcagaact taagagtatg agtcagtcta gatcttttca 139380 tcacaatact ctgctcctct tactttttcc tgaaatttgt cacattgaca gcaatgtgat 139440 ccctaatgac acacagattc ccaaataatt tttgtagtaa aaatttccat ttgcaattct 139500 ggacatgtgt gtgtgtggaa ttttatgtga tgacatattg gtcctatctt ttgaatagga 139560 tcataaatga aatgacttat ggatcacatt caaaagcagg ccaggggcca atgtgtaagc 139620 aggtgggttt tcatatttgg agttctgtac ttttgtgtta gtcagtgggt ctaggactct 139680 tgtagtgtat ttcccaaggg ccaaagtctt ctgccttgag gtgtcagctt tccaaggcag 139740 aggctggatg ctttctcttc cttctgggct cctttctctt aggcttcccc cttctcttct 139800 cctccatttg tatctgtcct ttttctcggt actttccctg gctggtctca gctagatgct 139860 cactcaatgc tgttgaataa atgaatgaat ttcgtagtaa ttctgcaggt aaatcaagtt 139920 attgtctccc aatacggtgc tatgctttct gaggaaatta gactggaagt caggcttttt 139980 aaaaaagaag atgtggtgtc aaattgcagc tctctctctc tctcgactta ccttttttct 140040 atcatccata tgccttcttt cttgtatctt tgggttccca gacctcacca ttcattagca 140100 cttggaatgg attggtaaga ataaagaaag gagaggtggt gaaactcagc ttgggtcatc 140160 tggttacaca ttagtaactg acaaaagata aaaagataca gactaaatgg gtttttaggg 140220 aactttttcc agtctattct tgtttcccat tagtgtgaaa aatcaacact tgcttgtatt 140280 ttggggtgaa gacatttttc ttaagtgagt gggaaagcct cttgacattt taccgagagc 140340 cttaaatttt gaatggtgaa tgctaatgtt ctttgtgcat aaagaatttc agaacttgta 140400 tatatgagca ttaatgatgc atcattttct atttgtgagt taaactaggt attatctgta 140460 atcatatttt taggaaacat tcaaactttc atcaagtcat tctcttatat gactctcagc 140520 tccattaact ctgttttcat ggaactcaac agagttctta acgtttgcat tataaattaa 140580 attagcattt cccctcaaag aagtattgct gtccttacaa taaataattg tagacaattt 140640 cttttctttt cttttttttt tttttgagac aggttctctc tctgtcaccc atgctggagt 140700 gcagtggcac agtcacagct cactgcagcc ttgacctcct gggctcaagc aatcttccca 140760 cctcaacctc ctgagtagct agaattatag gtgcacacca gacctggcta atgtttaaat 140820 tttttgtaga gttggggtct tgctatgttg cccaggctgg tctctaactc ttgggctgaa 140880 gcattcctcc caccgcagcc ttccagagca gtgagattac aggtgtgagc taccatgccc 140940 agctaattgc aggtgatttc taatgggatt tagtatttct gggtttaagg atgagatctg 141000 aggtaatgac tttgtttcca gatgtgaaat aatttgctct tgggttgtga gccctttggg 141060 tgggctccca aggatcctgc tctcttccag gagcccaggc tctggggtca gactgcctgg 141120 gtccttgact ccctgttttc tgattgtaca actttggtga gtggcctaat tcctctgtgc 141180 cttggctacc ttggttacta tttctaaaac aactggtgtt gtagtagtac tgcttagagt 141240 actttcaagg gttaaatgaa ttaatccatg taaaacgctt aaaatagtgc ctgccacaac 141300 catcaattta gtgtgaaaat ctgctcacct gcttggccag cccctttcac tttattaaac 141360 caagggtcgt gctgggtttt ccagaagtct aagttgcggt ctaatctttg tgcagaagct 141420 gaaatagcag ccataacgtt ctccctagat gatttcgtgg agcttctttg aactgtatct 141480 atctccagtc atttttgtgg aagaaatttt cttctgtact ttttagggat gagaattacc 141540 tgccttggtt tattaactaa aagacaccat gattacaaat aaaattaaat aaatattgta 141600 tcactaaata gataatatga gatagatgta ttaagttttc agataaacag tataaaagag 141660 ctagagtaat ttgtaaaaag ttgggaggac ctattttgtc atgcaggaaa caatttttaa 141720 cttgcctacc ccagaacata gctaccacat ggttagggtt tgcccaaacc tggcccagga 141780 gtcatttacc ttgagctttc ctaaaaagga ggatcaggat tttcctctcc agactctatc 141840 attttaggta gagtccttct tgtcaattct ttttaagaac atacatttac ttttgtggaa 141900 aataaataga tacaaaataa atacatacaa aattgcatag caattagaaa tacccaggag 141960 gtatgttatg gtcacagaca caaactgcct ccaacttctg tccatccata gtgatattta 142020 aagcagagag aggtacacag gtaaccacat ttagatggac tgggatgttg ccacacatac 142080 aagcattgat aactggcttc tcattacctg aatacattct tctgtcagag caacagactc 142140 agctatgctt ctggcaaaat tgttcttaat tctctattga ttaatttatt cggtaagtat 142200 ttattgggta ttttctgtct gaaaagtgcg attccaggtg ctttatgtgt ctctgtgtgt 142260 gggtgttata taaatactta taatactgta tccatactct tgaaaagctt agttgggaag 142320 gcaaggcatg caataaggaa cacagaattt tagtcattcc acaaccatct gttgaatggc 142380 tgctattgtt agtatcgtgg tggaaactga gaagcaaaga tgactataat aggatctctt 142440 ttctggagat gcacagtgga cacgtagtta tatgatgatg ataaggactc cagaatagtt 142500 ctatacatga tgctctgggg ccacatgcag attctgatga gaaacaatta actctttttg 142560 gctgctacct gagaaggggt aattgtcact caggaggttt ttgccttttg accaacatag 142620 aaaggagtgt gagtgaaggc tagaggtgta ctaacttggt cagggcaggg tgacacataa 142680 aattaaccat cacagggaag ggtagggctg gagaggcaga ctgtggccag gttacaatgc 142740 gctgaggcta aggagactgt gtttatcctg taggccagtg ggtcttactc tgaagtcttt 142800 tgggtgggac attcatggac ttcaagagac ctgtgaatgc cctaagatta taagtaaaat 142860 ctgtgagtct gtaactaaag ctaaagctat ttttctgggg cccaccatct aaagaagatt 142920 ctgaagcctt agggtagccg tggaggagac atgaaggtcc attttgcatg gtagaaccct 142980 gcctggctct tgctgcagtg tgggaggaca ggtttgcaat gtggaggtgt ggcaggcatg 143040 gatttgggag gattggcaga ggactcacca tgtccataca ctcactgaga tggcaaatat 143100 ttattaatca tccaactgtg tatcagacac taagaataag ctgggaggcc atggcaagtg 143160 aggtcaccac agtccctgcc acagtggagg ttatggtata caggtaaggc agggaagagc 143220 actgcaaagg gtttgcccat tgcatcagtc atttatttat gcacatgttg attcaacaat 143280 tatttctatg ccaagctgtc ttcaaggtgc tggaggaaat gaagcgtaca tttcactggg 143340 gaagacagac aataagtaaa cacattaaaa tctggcttgg cttgatgttg gggaggggtg 143400 agtgccatag agaaaacaaa ccatttatgc agccaacaaa catatgaaaa aaatctcatc 143460 atcactggcc attagagaaa tgcaaatcaa aaccacaatg atataccatc tcacgccagt 143520 tagaatggtg atcattaaaa agtcaggaaa caacagatgc tggagaggat gtggagaaat 143580 aggaacactt ttacactgtt ggtgggagtg taaattagtt cagccattgt ggaagacagt 143640 gtgatgatcc ctcaaggatc tagaaccaga aataccattt ggcccagcaa tcccattact 143700 ggctatatac ctaaaggatt ataaatcatt ctactagaaa gacacatgca cacgtatgtt 143760 tattgcagca ttgttcacaa tagcaaagac ttggaaccaa cccaaatgcc catcaatgat 143820 agactggata aagaaaatgt ggcacatata caccatggaa tactatgcag acataaaaaa 143880 ggatgaagta atgtcctttg cagggacatg ggtgaagctg gaaaccatca ttctcagcaa 143940 actaacacag gaacagaaaa ccacacactg catgttctca ctggtaagtg gaaattgaac 144000 aatgagaaca catggacaca gggacgggaa cattacacac ctggggtcta tcagggggtt 144060 gggggctaag ggagtgatag cattaggaga aataccaaat gtagatgacg ggctgatggg 144120 tgcagcaaac caccatggca cgtgtatacc tatgtaacaa acttgcacat tctgcacatg 144180 tatcccagaa cttaaagtat aattaaaaaa aaaagaaaag aaaacaaacc agtgtaagag 144240 gatggaaagt aataggctcg tttagaatgg tgtgagaaag ccaggcaggg agaaggcgct 144300 gagacaggga ggtcctggat gtgtttgtgg aagagctgtg gcagcacctg gaacttgggg 144360 agcaagggaa ggagtgtggg caggcaaggg tgagggtgca gggggtcatg ctgggccttc 144420 caggtcacgg aaggacttga gctttactct tgttgtggtg agaagctgct gagggcttgg 144480 agttagggga gtgaaaagat ctctactata atagggagag ttcgggatct gtaacttaac 144540 cccaggagcc agcaaagctc cctggaggaa atgcagttta agctgagaat gggaggataa 144600 acaggtgttt ttcagagaag aggaagggtg ctctaggcac agagaacaac atgctggaat 144660 gcttctacta gatcataggg gcaaaatggg agtgcaggag taggagaggg ctttctggga 144720 aagatactta ttttaatttt gcatgcattg agtttttgag gtttctttgg tttgttcatg 144780 tggaggtgca gagtgggtat ttagcacata ggtctgaagt ccaggggagg ggtgtgggac 144840 agcagttgga tgtggcagag attccacaaa gagcaaatat catctgagaa tggcagaggg 144900 ctgagggcag agccctgagg aacactggtg tttaggagcc tgctggagaa agaaaatact 144960 gcaaagggaa cggaagtgga gtggttgcca gacatagaag ctagtgtcta actagatgtc 145020 atgagatgtg gggaaggtgt tacgtatcta agaatgcaaa gttgaacccc tgtgaactgt 145080 aatacttaag ataagtcgta taaattgtct ggaactagag cttgattttc caggagagat 145140 gaaatgtgtg taggtgacag gaaacaatga atatgtgggc gagtgtagtg tgagcaattt 145200 ctcagaggtg aatttgacag cattttgctt aggaagctac aaagagacca atgctagttg 145260 gtgcaaggaa ttcaagaatt tggacttaag tctatataat gatgattttt tttttttaac 145320 ttgagtttcc cggtttatca ctcccagaat ataggcagaa gtttgagatt tttatgtgta 145380 ttttctggaa aagatagttt cagtgttttt tacattctca aacaggttta tgatccaaag 145440 aaaaggcagt ggtcacagat acatgaaacg acaaggtatt caaaggagaa cgttgtactt 145500 tatgacagtt ctttgggcag tggcttgcag gatgagtttg aggaatgatt ggaggcagga 145560 gagtaattct agtaattcaa atgtggagta ttgttgatct ctcagacaca aatggaaaaa 145620 caaggaattc aaagaaagat aggcagagtg ttttgaagaa ataattgatg aaatttggta 145680 atgagttaga tgtaggagat atatttagca aatatttatt aaggactgta ttaatctgtt 145740 atcatgctgc taataaagac ataccaagac tgggtaaatt ataaagaaaa agagatttaa 145800 tggactcaca gtgccacgtg gttggggagg cctcacaatc atggcataaa gcaaaggagg 145860 aacaaagtca cgtcttacat ggcaatagag tgtgtgcaag ggaactgcca tttataaaac 145920 catcagattt catgagaaat attcactatc atgagaacag cacagacaaa agcctgccac 145980 catgatttaa ttacctccca ctgagttccc ccaggacaca tggaattatg gaagctacaa 146040 ttcaagataa gatttaggtg gggatacagc caaaccatat caaggaccta ctgtatatgg 146100 ttaaaattgg gagcaaatga gacatgattc ttgccttctt ggagtttact gtttactagg 146160 ggaacataca cttgtcaata atcacccaaa tataggattg gaaattgtgg taagtgccat 146220 gaaaaacaag tatagggaat tttgagtgta catagctttg gggacttgat ttgatgaggg 146280 agccttatga agttattgca ctagaactga attaaaccac atttctagga agtggacatc 146340 tatttgttgg ttctttaaat ttagctttac agaaatattt cctttaaaaa ccaaggcttc 146400 ttaaattttt aaaactgctt ggctaatcag gggaataatg cttttggata gctggtatcg 146460 ttatttatgg ttggaaaaac aacagtattt gattacattg agctttaaac ttttcctttg 146520 attaatgaaa attttattgg cccatagttt ttattatgct ctgtttttac ttggtccaag 146580 agattctatt ctctggaccc aatatgaata ccttcagaca tccctctttt tttttttttt 146640 tttcacccag gctggagtgc actggcacga tctaggctca ctgcaacctc tgcctcctgt 146700 gttcaagcaa ttctctgcct cagcctcccg agtagctggg attacaggca cctgccacca 146760 cacctggctt atttttgtat ttttaccaga gatggggttt caccatctcg gccaggctgg 146820 tcttgaactc ctgacctcat gattcaccca ccttggtctc ctaaagtgct gggattacag 146880 gcatgagcca ccacacccag cccagacatc cctcttaatt atgttgaata tgtaatatcg 146940 gtgatttcat ttgaaaatat ttagtagtcg aactagatca aggcagttaa gcttcctatt 147000 tccatagatg cagtggtatt gtgtcttttt tatatgatct ctcatgcttc tggacatcct 147060 tttttctgct attcttcatt ccttagctac acttggtgct tcgtggttgt aatgcattgt 147120 catagatgcg ttcatttctc attcgatctt cagctctatt tctttccaga gaatctctac 147180 aggcatctgt taggttgaag gacatctaat gtcttaatgt gtagcttggt aaaccagtca 147240 actttctatc tgagtcttaa gagaaagtgt ccaagatgag aaacggtaca ggtttggtga 147300 caactcagtg agaaaaagaa gaattttaca aggaaggagg tatcttagta attttgctaa 147360 agaagtaggt aaaccttcac ttataataaa gggatagggc tcggttaggg tttgtgaagt 147420 ctccccttag gaaagcaaac cctgaaatat tttgaatctt ttaaagaagg aaaataagag 147480 tcttttaaat aaatttttaa aatttatttt atatattttt tatagacagg ctctcactct 147540 gtctcccagg ctggaatgca gtggtgcaat catagctcac tgcagccttg aatgcctggg 147600 ctcaagcggt ccttctgtcc cagcctcctg agtagctggg actgcaggca tgagccaatg 147660 tgcccagcaa gagacattca ttttggtact gtgatggtac agaaaaacaa agggcctttg 147720 aggccgaagg agcagaagaa ggatggactt agacatggta taggcacttt ctactaaaga 147780 gctgtgaagc taaaaatgcc aggtctatga caggtgcagt gggccaaggc caggtagaga 147840 gcagcaggaa gagaggaggt ggggacctgt acctaggccc atctgctggg actgatctag 147900 ccataggtac tcagagaagc ccagattggt gcctgaccca cccttatggc ccagacatgg 147960 acacctccca gtctgttcct tcctgctgcc catggatggg ctgtgttagt ctgtattctg 148020 aggacacagc tctctgtcta gaggaagtta tgttatcttg atctgatgga tactcaacgt 148080 gaacattatt tcaacgtgcc acagggtctt ggagcccaga ggaagaccgc tcttgccttt 148140 tagtttatat tctttgtttt tttttaaata acattttgac agtctttatg gagtaagtct 148200 gggccaaaat gataattgac aatgttattt acatggattt ctaagttggc taaaaaagtt 148260 cctttatggt tagtgaatat agcccatgta gtttccccgt cttctttaga tgccttctat 148320 ttctatgccc aaagtctgca gttgattttc agtaagctgg gggtcatctt agagataaaa 148380 tgtagatgaa tggcattttg ctgacagcat acatctttgc tatttctgag gaaaatgggc 148440 tctcgctatt aaatcttttg tcaatattta taaaaatagt atttacatat tctatctata 148500 ttgtggaaac tatacattta ttgattcagt catttgatat caatgttgtt gagtccctat 148560 tccaagtgag gcactatgct ctaagcacat ggcattttaa agatgaataa gacaccaaga 148620 actttgcaga tagtaatgga aatgagaatt aatcaattga agattaatat agtaagtagc 148680 agaagagaaa taaaaaaatc ttctagagag ttcagaacag ggatgttgat tcaagtttat 148740 ggggattagg agtggctggt aagggaggca ttcaggcaaa agacataaaa atgcagtatt 148800 cccctcgcac tcattaggat ggctactata ttagaaaaag aagagagtaa gtgttggaga 148860 ggatatagag caaatagaaa ccttgtgcct tgttcatgag aatgtaaaat ggtgcagcca 148920 ctgtggaaaa cactggtgat tcctcaaaaa atcaaaatag aattatcata tgatccagta 148980 attctacttc tgggtatata tctaaaagaa ttaaaaatct gggtcttgaa gaaatatttg 149040 tatactcata gttatagcaa cattattcat aatagccaaa aagtagaagc aatccagatg 149100 tctatagatg gatgaatggg taaacaaagt ctgtgtagta tatacagaca atggcatatt 149160 agtcacatca tggaccttca ggacattatc ctaagtgaaa tatgctagac acaaaaagca 149220 aaagtagggt ttcacttaat gaggtatcta gaattgccac attcacagag aacaaaagta 149280 gattggtggc tgctagggga taggggaagg agaaaatggg gaattattgt tgaatgggta 149340 tggagtttca gttttgtgaa atgaaaatgt tctgaagact ggttgcacga tgatgtgagt 149400 atatctaaca tgattgaatt gatgaacact taagcgtggt tacgatggta aattttgtgt 149460 tatatatatc ttaccacaat ttaaaaaata tagcatttta ttatgtaggc gtgggtggga 149520 agatacttga cacattggaa cttctggcca tgcgtatact gttcactcac ttattccttc 149580 attcattcaa caaacatgta ttgaatgctt gctatgtgct gggcactgag ctagatataa 149640 caattaataa ggcttataag acattgaatc tatcaatttc atgcttgcta aatatctact 149700 cccacctcca aaggcactaa gcttctacag ttagatattc atagctgctt cctactgact 149760 tgaatcatgc ataggatatt agtaaacaag caataaaaag atttgaggtt gatgggggtg 149820 ggttcaacag catggtggtg aaatggaaag agatgggtaa cagaatatga actagaattg 149880 aaaactgtga gccagtgctc tctaatgaac attaaaaaat aaagaattcc tatttgaggc 149940 tgccaacctc agaactaagt tatttagaat ggacgaaatt ggcaaagtca gacgtactca 150000 acccaaggag ccaatatttt gtgaatatta tggcaaatgt agtttgagaa ccactaccac 150060 aaaattgtga accataataa tgactgagaa ggcagggaga ggttatacaa tttgggctaa 150120 aaggaaagac agggcttgtg aaggggagcg ccagtgaaag tcagtgtggt tcgggtattt 150180 gggtggggac tggaagcagg aagcttgagc ttcctttgcc aagagaccct gctggaaggg 150240 ctatcatcaa ttgactttag ctcatcttag gattttcatt ttttaaaaaa tgttcacagg 150300 aaccttcact ccatctatac tttcaatgtc tgcctacctt tctttcttat acaactttga 150360 acactctctc cattcattta aatatattat ggagtgccaa ctacatgcca ggtactgtgc 150420 tgggctctta ttccaccttt atttgattgc acatgcctgc caagtcctgg gccaatataa 150480 catctactcc tatgtctggt ctggcgagag atgcaaactc atcttcctct actttcctta 150540 cctccttcct tccagtcttc ttcaagttgt cttcattgag gcaatttctt ttacctgtgt 150600 ttttaatccc aactcctcta gtttccttct tggctttatt cttttatctt cctctttgtg 150660 ctttcaaaca ttccctttct cctggcccat gcccttcagt ctacacgagg ccttctcaag 150720 tctcttcatt ctaaaaaatt cattttcttg ggtcttatat tcttcagctg ccaccctatc 150780 tgtatctttt cctattctcc tccaagttct caaaggaatg ccttccctca ttttcatctc 150840 cttacattcc atctgctgaa ttttggcttg tgcctgtacc tgtctaagga aactccttgc 150900 taagagtctg ctttgtcagg tctgaattca cttaaccagt ctttgctttg ttggacttct 150960 ctgccccatt tgccattctt gatcatcctc tccataaacc tttctactta aagcatttta 151020 cttccttatt ttcttggttt tcctagaatc tccttactgt tcattttcag cttcctttct 151080 gtgttcctct tctcttccta catttttttt tagctttcta ctttcttaaa gcattttact 151140 tccttatttt cttggttttc ctagaatttt cttactgttc attttcagtt tcctttctgt 151200 gttcctctga ttgtctctct ttctacattt tttttttctg tgttcctctg attttcacgc 151260 agtctggagt tgtcatgatc aatcatagcc tactgcagcc tcgacatcct aggctcaagt 151320 gattctccca cctcagcctt acaagtagct aggactacag tcacacatca ccattctcag 151380 ctaatttttt taagaagcat ttttatagag atggagtctt gctatattgt gcaggctggg 151440 ctcaaactac agggcttaaa caattctcct gctttggcct cccaaagtgc tgggattcca 151500 ggcatgaacc accatgctca gtctctacat gttcctaaag aggagttttg aatattgaag 151560 aacagtattt tcaaattaca ttattcaagt tataaaaact gatatccagg gttatgtggc 151620 aatgacgtaa aaatttgaat tgttattttt ttgacacatg ttctgtgttg tccatcagtt 151680 catctgagtt ccaaatgtcc cagctgtttt atgctttgtc tctgtttccc agagaccctg 151740 agtgtggtct agagttggga tgagcattgg tctctaatgg ttctgaaata attgtatatt 151800 cctgcaaaaa cattaagtct attagaaacc agctaatttc attttgtcat ttttataggt 151860 aacatattct ggtgcaggta gtatgttttt aaaacaagtt tgcaataaac aatttcccct 151920 caaggttaat ataataggca acaccttttg ctgcaacaga cggcaagagg taatgaaaga 151980 ttagcttaca ttatgattca ttatttcaaa atgtcaggat aaagtggatc tgctgcatct 152040 cccagagagt gcatgttttg cttttctaat gttaatggat ttactgtttt tttcccccca 152100 ggccaaattc agataatcga cgccagggtg gcagagaaag attggccagt accaatgaca 152160 agggaagtat ggctatggaa tctgccaagg agactcgcta ctgtgcagtg tgcaatgact 152220 atgcttcagg ctaccattat ggagtctggt cctgtgaggg ctgcaaggcc ttcttcaaga 152280 gaagtattca aggtaatagt gtgttgaaaa cgacttctat ttttgatcct atgagcagat 152340 cctaagagcc aaagcgactg aggaaggaag acatagaatc agccatttgt acaaaacatg 152400 aatccctagt aggtccacta gtatctttgg tagaaacatg gagaagagac aggatctcag 152460 gagaaggagt tgacacatgg cagggcagct gaggctgagt aattccgctt ccttcctttg 152520 gcaagactca atcagtcttg agcaactcta cagaagaatt ccactagctg gatctctgag 152580 gaaaaaagaa atgttgtctg tgccctgact ggggaatgcc agatggacat tcatgtttgg 152640 taggcaactt tgcctatatg atctggtata tgctgttaat tgtccatgca taattatctc 152700 tctactcagg ccttgtccag gcaaatattc tgttttgttc tagtttagct tgttctcccc 152760 tttctctctt ccatctcttt cttgtctcaa tggatgacag gatattttgc tatgagctga 152820 ctcagtggtt ggtgtcttgt aatggggaga tatcatcttt atcaaacagt tattaagtat 152880 ctacctgtag catttcattt tcccgcctgc ctccattgtt ttcttgtcta tagtttgcca 152940 attatagcta atatacggag agctatactt tatttctact ccagaaatgt ctctattatt 153000 gcattataat aggataccct ggggaaacac taatcatttt tactacctaa aatacctatg 153060 ctgaatatcc tttatctgat aggaacagag atctgacagc agcttaggct aaccaaattc 153120 attttttatc ttaagtgtgg ggcatttttc tctcttctta ttctttacct tttcagctta 153180 agtgaaggtt agtataaaca ctaagaatat ttctgatgga gttttcatgt gattccttct 153240 acaaaaaccc agatttaagt aacttgttga aaaccagagt ccgctaagtt aataaacact 153300 gattgaagaa gtgattctca tggactttct gtgatagctc tttcctgccc tgatatgaga 153360 tgaaagctgg gggatggtat atagtattta tttttccttc cgttgccagt gggacttttt 153420 tttttttttt aaaagctgtt catatcttaa tcgagtagca tgtgaggtca acatggtcta 153480 ttttaaaagc attttcttcg acacattgct tttaacatct tttagaactc tgctgtgaga 153540 cacatggact tttttgttgg tatttttata caattaatga tattctcaat agtaatcttt 153600 gtgtgtgtat atatatagaa ataaattcta aatgtaagtt aatatattta ttatttttct 153660 aaacatatat aaatatatat atgcacacag gctatttaat tttattagat gatgctattt 153720 taattcagaa aaaaatgaca tttatatttt gatttaggtt agtataagcc cttagaggtg 153780 ttttgacaac tctcttaatt tgtggtttta ctgtttattt gattttatat aatctaaaat 153840 accattgttt ttaccaagca tttaatttgg cagtgaaaga gcgtctgaca gaggtatggt 153900 tagtagatag gtctaactgc acaactggat ggattgagct gagactgttt cctcatcagt 153960 aaaaatgatt tgaagcagtg gttggcaaag tttttctgta aagggccaga taataatatt 154020 ttaggcttta caagggccat gcagtctctg ttgcagctac cgaactggat tatagcctgt 154080 aaggtgacct gtaaacacat ggaagtgatt atgtgctaat aaaactttat ttatcagaat 154140 aggtaacaga tcagccctgg cccgtggccg atccctgatt taatgtttat ttatctgatc 154200 taaatacctt tatttatgga agggaatagg ggatttttaa atctaaagtt ttgattattc 154260 acattttact gagaacttac tctatacctg attagatgtt ccgagagaaa taaaaaaaaa 154320 gtgtaagaca taatccataa taccacaaaa tttaaaatgt atttaggaaa tttatttgag 154380 gaagtaaatg tacttgttct catgatacaa tcagaaagta agtcagtatt gataaagtgt 154440 tacctgtatg agaaagataa ggaaaacaat agagagatgt aagaaatgaa aataccagtt 154500 ataaattaaa attattaaga ttgaaagtgg aaatgatctt cctccgagaa acaatggcaa 154560 tattctcaca aattttttac atcatttttg ttcagcattt aagataaaat tatataaatt 154620 cccataacat ttagtattgt ctctaagcat taagaacaga aaaaacagaa ggaaaatata 154680 tttctaaaaa tcaacgaata cagtgtgaga tgtttcattg gtatggcatt atctcaagtt 154740 caaacatttt gaaaaatgtc tgcttactct ttgatagtta aaaacaagta tctcagctgg 154800 cgtggtggct caggcctgta accccagcag tttgggaggc tgaggcgagt ggatcacaag 154860 gtcaggagat cgagaccatc ctggccaaca tggtgaaacc ccatctctac taaaaatatg 154920 aaaattagct gagcgtggtg gtgcacacct gtagtcccag ctacttggga ggctgaggca 154980 ggataattgc ttgaacctgg gaggcagagg ttgcagtgag ctgagatcat gccactgccg 155040 tccagcctgg tgacagagtg agactccatc tcaaaaaaca aacaaaacaa caccaccacc 155100 actaacaaaa acctcttatc gccgtcttgt atacgcagac cagctagtag aattttactg 155160 aaacagtagc ctataaaaat gcaattccac ttggtttcag aaacttcttg tgtatcatag 155220 tgtgaagtca cttatcttag gcttttaaaa tgggataaat attgagtcca aagttctgga 155280 agaagcctag aaagaaggca gagttattaa cttttagata tagggaggaa ccttaaaatt 155340 attcagttct tcattcattc acttattcat tgactagctt tactaacaaa gccctatgca 155400 agaccctgga aatgcaatga tagaaaaacc tggtccctac cctcacagaa cttgtgaggt 155460 aaagggggat acagactgat aaaccagcaa ttagatgatg gtgtcaagat agaggtgaag 155520 gcagtgtctt ataggatcca aactccactc agtcctggtg gtggttgagt ctggctatca 155580 gaggtttcct gattaaatct ggagggtgag tcaagggagc atggtgaaga aggagggaat 155640 gcatgtttag ccatgtgaat gagtccatga gtgaagacca ggaggaaagg cagagcgcgg 155700 ggaattctat gcgtaatatt taacaaaatt aatgtactgt taaacaaaga catttctggg 155760 ccatggattt aatcctagac tgtgtaaaaa ccaagtaatt gatttccttt atactttaaa 155820 agcatttcca tgtatttgat ttgtttgtgt gtataaaagg gaaataccac aacaagttta 155880 agggtttcta gttctgcttt ctcatcatag tcttgataac ttggaactaa aaagtttttg 155940 ctgaaattgt ctgtgactct ttataaatca cactgcccct caaacacatt taaggatggt 156000 gaagggtctg acacgtaggt gggaagttct gaagatgccg cagctctccc tgttttcctt 156060 gttacttaag aagagagcta gaaatgagtg tacatcagat tattctcatg ttctaagtgt 156120 tttggttgaa gaggtaaagt gtttggcttg aaagcataca aattttcatc cactacttag 156180 tgtacaaact tgattactta agagattgag taatggcctc cagtgaaacg cattcttttt 156240 aaaaagcaaa gtgaaggatg ctatttaagt cagaaggggc aaaattggat attttatgag 156300 tttattaatc attgcaggca tagaagtagt gttccttaag atgtgtttta gacagagtcc 156360 ctgggatgag ttatataagc agatctggtt gtagcttcag cagccagata ctacctttga 156420 gtattacttc aaggaaaaag gactccactg agctcactgc ttctctttca ttattatttc 156480 agaaggttgt gtggcgtaga gggggctcag gcctacctat acaccactag ctatgttgcc 156540 attttatatt atttctataa ggtgccaaca gaagctgctc atcagatcag acagacatag 156600 cccaggcaag tattgattta cagatgatct ttggccagga agacatggta tcagggtaga 156660 gtctggttat gggtcaatgc agtggggacc ttaggtccta caggtataac tgagagcctg 156720 atccaccagg ccttagaaag cttcagggtg agacagtcca gcaccctgga tagctccttt 156780 aacagctgtg gccggtaagc aggcacttat ttgctaaaga actcaagccc atttagctgg 156840 cttcatctgc tttgtagagc tctgttaaaa agagttccta tttctccaca tcctctccag 156900 cacctgttgt ttcctgactt tttaatgatt gccattctaa ctggtgtgag atgatatctc 156960 atagtggttt tgatttgcat ttctctgatg gccagtgatg atgagcattt cttcatgtgt 157020 tttttggctg cataaatgtc ttcttttgag aagtgtctgt tcatgtcctt cgcccacttt 157080 ttgatggggt tgtttgtttt tttcttgtaa atttgtttga gttcattgta gattctggat 157140 attagccctt tgtcagatga gtaggttgcg aaaattttct cccatgttgt aggttgcctg 157200 ttcactctga tggtagtttc ttttgctgtg cagaagctct ttagtttaat tagatcccat 157260 ttgtcaattt tggcttttgt tgccattgct tttggtgttt tggacatgaa gtccttgccc 157320 acgcctatgt cctgaatggt aattcctagg ttttcttcta gggtttttat ggttttagtt 157380 ggtgggactg taaactagtt caaccattgt ggaagtcagt gtggcgattc ctcagggatc 157440 tagaactaga aataccattt gacccagcta tcccattact gggtatatac ccaaaggact 157500 ataaatcatg ctgctataaa gacacatgca catgtatgtt tattgcggca ctattcacaa 157560 tagcaaagac ttggaaccaa cccaaatgtc caacaatgat agactggatt aagaaaatgt 157620 ggcacatata caccatggaa tactatgcag ccataaaaaa tgatgagttc atgtcctttg 157680 tagggacatg gatgaaattg gaaaccatca ttctcagtaa actatcgcaa gaacaaaaaa 157740 ccaaacaccg catattctca ctcataggtg ggaattgaac aatgagatca cttggacaca 157800 ggaaggggaa tatcacactc tggggactgt ggtggggtcg ggggaggggg gagggatagc 157860 attgggagat atacctaatg ctagatgacg agttagtggg tgcagcgcac cagcatggca 157920 catgtataca tatgtaacta acctgcacaa tgtgcacatg tacactaaaa cttagagtat 157980 aataaaaaaa aaaaatttaa aaaaaaaaag agatcttagt tcttttgggc ttggggactc 158040 actcttgttc acttaaagtg gattggttct tacatttatt ttcatagttg tgtctggtca 158100 ccttctggct tgatgtatgc ccctatgtct ggaaaaggtt agagaatggg gtagaagtgg 158160 aggctgcccg cccatcatgt aactgtttta tcttttcaga gatacaattg ggatcctaac 158220 tctttggtct ccgtatttcc acacttgctc ttatacgatt cagtttccat gcaacagcag 158280 gagagatatt ttagatatat taatcaggtc ctatggtctt gagtttacag ctctcagtgt 158340 aaatcttact ctcaagagaa aaattttcct tctgcagctg aaaacattcg acatattctc 158400 tctcctattc cttctccccc attcactgta ctccaggcac accagctttt atttttattt 158460 attttttgct attcccccca acacgccaac atgttccttc ctcaggatct cagcacatgt 158520 ggttcccttt ttccctttgc ttgaaatacc cagatcttta cttggctggt ttcttgtcat 158580 tcagattctg cccaaagtca ctttctcaga agtagtgtta cccttccacg agtaatacta 158640 ctcttacttc tctttacagc tctcaaattc ttatgaagtt ttcctattta ttcatttgtt 158700 tgattattgt ctgtctgcat caggtaccgt gcaaacttgg atgtaaactc agtgatagct 158760 gatttctgtt cagcattgtt tgttgctata gctccagtgc ttttagtcat gttgggcacg 158820 tccctactaa atagtagaat atggcgaagg gtcagagtca tgatagatag ccggatgtgg 158880 tggctcatgc ctataatccc agcactttgg taggctgaga tgggcagatc acgaggtcag 158940 gagttcaaga ccagcctgac caacatggtg aaaccctgtc tctactaaaa atacaaaaat 159000 tagccagttg tgatggcatg tgcctgtaat cccagctact caggagactg aggcaggata 159060 attgcttgaa ctcgggaggt ggaggttgca gtgagctgag atcgcgacac tgcactccag 159120 cctgggcgac agagtgagac ttcatctcaa aaaaaaaaaa ataataatga tagataaaaa 159180 ctgctagagg ctctctgaga aggaagaaat gtcactgggt taggttggta agagaagtgt 159240 taatgcaagt ggtacatttg atataagcat gcaaataaat ggtagtttgg aggaaaattc 159300 cagaaatgtg aaacagtatt gagaaattga gtaagccagc tttgagagaa cacacggctt 159360 attgtcctct ccttctgttt tgctcctcag ctctctaaag tgggcattct ctagggtcct 159420 gtcttcaatc tcagcttctt tttcttcttc atccttctct ttccacctag tttcctaggg 159480 aattatatat atatatatat atatatatat aattttgtat atatatacaa aattatatat 159540 atatataatt ttatatatat ataattttat atatatataa aaaattatat atatataatt 159600 ttatatatat atacaaaatt atatatatat gtctggtaca ggctgaattg tgtctcccag 159660 aaagatatgt tgaagtccta atgctcagtg cctcagaatg tgaccttatt tggaaataat 159720 gtcattccag gtgtaattag ttaaggtgaa gttatactgt ggtgtaaccc acagtatact 159780 tccagtatat acttcagtat atgggccctt aatctaatgt gactgatatc tttagaataa 159840 gaagaaaatt tggacacaaa cacagagaag agaatgtcat atgataacag agagagagag 159900 agagaagaga gagagggagg agagagaggg aggagagaga gggaggagag agagagagag 159960 aaggagaaag aaagagagga gacagaagag aaacatctac aaagcaagga acaccaaaga 160020 ttgctggtgc ctaggaaact aatataataa cataatattt ggggcctaaa gtgttacagc 160080 tgcaccaata tctcccaaat cttgctccta gctcctgccc cagcctgatt ttctcagtga 160140 ctcccctgtg tttccctctg ccaccagccc ctccttctgc ctgctgtgtg tgacagttcc 160200 cttgccactc cctccggcat ccgtacttca aactggggag ttagttattt ccattgtttc 160260 ttattgcagc ctctggctct gacgtttcca gagctgttgc atagctctat tgagtctatc 160320 tccttaaatg cattttcatc cacttaccat tgctgagtta gctgcattac ctttcaccag 160380 gatgcttgca ataatttatt gtttccattt gccttctcct tcatctaagc cgtttgctta 160440 tgtctttttt cttgttgcga gacattctgc acattgccac tctattagtg gtcataaagc 160500 aaatcactga tcatgtcaat acgcagtaca agatccttta atgacctcca tagcccatgg 160560 aatggtcctt aaacaagagt tcaaggactg ccacaatctt gttctagcct atctttctag 160620 tcattttaaa gtcaccattt ttacttgtga aataggcact ccagacacag tgaattcctt 160680 gttcttctac aaatatgatg attccatttc tttgctggga atttctttcc agatttacct 160740 gtaaaaattc ttcgaaccct aatcaaaagt gactgttgtt aagcccctga agataatgca 160800 gaaattctct ctctcctggg acctcgatat tagtttattc cattgtattg catatatttg 160860 attgcccatg ttctgtccca tactgactgt aaagtcctta aaggtgaggg cccaatattc 160920 tcagagtcac tcaataaata aataaaagaa taaatggaaa ttaggatcag tttgtgggct 160980 ttagcaacac aaaaacatta tactttttca acatgggaga ggtatgatga aggagttttt 161040 tttttttttt gagacagagt ctcactctgt cactgaggct gcagtgcagt ggcattgtgt 161100 cagctcacaa caacctccgt ctcctgggtt caagcaattc tcctgcctca gcctcccgag 161160 tagctaggat tacaggcgtc caccaccatg cctggctagt ttttatattt ttagtagaga 161220 cggggtttca ccatgttggc caggctggtc ttgaactcct gacctcaggt gatctacccg 161280 ccttggcctc ccaaagtgct gggattacag gcgtgagccg ccgcacccgg ctgatgaaag 161340 agtctttaat gcagattaat ctggcagagg tatataggag ggaccagaga agggaaagaa 161400 tcaaagcgtg aagaccaatt tggctgatat tcaactagct tagatgtact aaaaatctgt 161460 actttttggt atttgtgaaa tggaaagaag gggaatagaa taaaggatat tataatgaaa 161520 ggatatacat tgcttgaagg taattaaata tgggttatcc aggagataaa agagttaaag 161580 aggttcagac atagactgaa tgaactgaga aatgaatgac ttggtcacca agaggaaggc 161640 cagtcatcag ggggtaggat aagttcaatt ctagacatgc tgcatttgag atgatagctg 161700 gatgtccaga tggaattatc cagcagccac agaaacagaa tcagctctct gcggatattc 161760 caggggtggg gatttgaatt aatttcctca attaatttta aagaaacttg atgaaaagaa 161820 tggtctgaat acttcttgaa ggttgcacat tattaataat ggagaaataa ctctaaaacc 161880 ttcctcttga ttttcataat aatataagca ttccctgaat cttaccaaac cttgtaagaa 161940 acactcttat tataaaaagt gtatgtgcaa agcccttcta aacaggaaaa tgataaatta 162000 gtcctacagg gccaaatgca gctctctggg agcttacaat tcagaaagaa catcctgcta 162060 ccagcacatt aagctgtaca aatagtaaac tgcagaaaca aatataagca tttttatgat 162120 gtccaaacaa gaaccaagca ggtgtttttt tttttttttt tgcagattat ttatactgtg 162180 gcagttcata gcctcctttt cggacccaga gcttgcataa tccttccctt atttctactt 162240 acgtgtttta ctctccatca tgtgttaaca tacatactgt gcaacagaaa tgactatgga 162300 ggctgagggc agcagagttt tagtgtgtac acatatgagc tgtcatgtaa ttttcaagtg 162360 aaagcctttg caatgaaact ttttaaaaga aagtcatggc cgggtgcggt ggctcatgcc 162420 tataatccag cactttggga ggctgaggca ggcagatcat gaggtcaaga gattgagacc 162480 atcctggcca acatgatgaa accccgtctc tactaaaaat acaaaaatta gctaggcatg 162540 gtggtgtgca cctgtagtcc cagctactca ggaggtggag gcaggagaat ggcttgaact 162600 cgagaggtgg aggttgtagt gagccgagat tgcaccactg cactccagcc tggcgacaga 162660 gtgagactcg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaagagaaag aaagaaagaa 162720 ggaaaaagaa agaaagagaa agaaaggcgg gcattaactt caggtattgg taaatttgct 162780 aggtgtttgg ctactgtttc tcatcagaga aatagaaaga cacaccatga aagtcaaggc 162840 ctgaaaacct cattccatgt aagaatgaca tccccagtgt taagtgcttg ttagtggtta 162900 atgcgatcct gtgaaactta gatgtgtttg tgcacacatg cacgcatata tttgaagaac 162960 tcagaagagt taaatcacag cctttcaacc tgtgaaatga cagtagttct tcttttttcc 163020 tctccctttg gctaagtcat ctttatcttg gagataatta agacaaaaat gcctctgaca 163080 aataaaatca gtatagaacc cctatttctt ggcagctttt gtggacacag ctgaagcttt 163140 cagaggtctt gaaaaaccat ggcaacaaat gcctttgaag ggtaagcaaa ggttccaaat 163200 gtttttaatc gctggtgttt tttctgctac cacttcaagc atttttcttc attttttgtt 163260 catctgatca aaattaaatt tccaatttcc ctactaagtg gttctgtcct ggtcatgcca 163320 ttgactattt ccattaaagt agtagagttt gtgcccacat atggttgtta agctcatcaa 163380 caattccatt agaaagcttt gtttatcagt ggcaataatt tcccataaaa attatagata 163440 ggttttaatg ggcacatttt caaaaggcat caactcgtcc tcaaaattat gtgctgacac 163500 tgttcttaca accatggttc gtggcctaat tccaccaaat ttctctcttt ttcatagaga 163560 actgttgtca gtagctttat atccttttaa agagaatggt ctgtatctct gatactcatt 163620 cagagaaatg agtattttag acgtaggttg ctaattttaa gctatatact acactatgtc 163680 agcactatat aggttatctt gtaacctgct tgcctggcta tttggctgaa aaataacaac 163740 atgtaaggaa aatctatttc ataagtctaa catttacttt gtaaaacttg ttctggctac 163800 tctgttaatt ttccacttac gtgtgggtta gagagcagat ttgatttttt tttaagcgaa 163860 agatatggct tacctgagaa aagaacatag tggggaaagc actcctatta ttttcctcat 163920 atttccattt tcctttagcg gaaataaaaa gacatttcag tttttcagtt gctaagaaat 163980 gaaggaacca aagacaaaac aacttaatta ttaaattaca atttatttct gtaataagca 164040 ctcgttctct ctgttttcct ggggaaagag tatgtggact ttcaatttta tccaaataag 164100 catcatcttt ctctgattag tgtggcagtt tcaaaatcat gtattaggaa gtacagagtg 164160 aatgagtaga gaatttctaa attagcaccc aaggttgggt ggctagatta tgtttataaa 164220 tatgaacttt tgtattaagt gcaatgattt aaaagaatgc ctgcatcact ttagggcatt 164280 tcattaagtg ctgtgcacaa tatttttcct tatacatcat aaaagataaa ttatagttca 164340 taaaatagta taaattccta attattttgt gcttttgaca cctcagagtt actaataagg 164400 gatttcgttt taaaatgata tttatttatt tatttagaga cgcagtcttt ctctgttgcc 164460 caggttggag tgcagtggtg cgatcttggc tcattgcaac ctctgcctcc caggttcaag 164520 cgattctcct gcctcagcct ccagagtagc tgggaccaca ggcatgggcc accacaccca 164580 actaattttt gtatttttgg tggagacggg gtttcactgt gttgggcaca ctagtctcta 164640 actcctgacc tcaagtggtc ctcctgcctt ggcctcccaa agtgctggga ttacaggcgt 164700 gagccactgt gcctggctcg ttttaaaata atttaaaagt atattttgcc accactatta 164760 accagttaag ccatgatggt atattataat caccatggag atggtttttc tctttatttt 164820 attttgtttg ttttctgatt gctagcatgc tgattactct tcctattcta caagtgcctg 164880 caggccagcc ccatttttgc tctcttcact tcatttttca tttctccctg tttcactctt 164940 catagcacat ttgtactctg tccacaccta gagacctccc tgttgaagtt cttcacattc 165000 tcttccctag agagggttaa cttgttgagc tcagagactt aaacttaaaa taaaatgtaa 165060 cagatatgta ttgaatgact attttatttt agctctagga gaaatgcaaa gatatatcat 165120 ccatagaccc tgaaatccag ctaagggttc tgcttataca caaggtgaaa ggttgtgata 165180 atgcacatta aacaatagaa gagttaaatt cagcactata agtgatgcct caaagcagca 165240 taatgggaaa aaggggtatt tcagaaaaaa atggtatgag ttcagaggca agagaaaaca 165300 gaatgctcta gattaaactc aaagacttta tggaggaggt ggtgtttcaa tagatacctt 165360 tccacagaac catgaagaga gttctactta attgtaagtg gcctgtgatt tgtcgttagt 165420 cattgcatgc tcaattctgc atgtgtgata actgtgtatt tttatggcaa aatcgcaatt 165480 acttttgcac caacctaata gaatagtgtg ggtttaaaaa aactatttgt aatatattcg 165540 aacatatttc ttatatatat gtttcaccat cattagcagt aaatctattt tgcatccaga 165600 gattgaataa tattttgttt ctaggatgtg agtgatgtac tattttaact tacttttgaa 165660 gtttgacatg ggagtgatat taataaaatc taaagatgct cctaaagagg agcaatagat 165720 aatgtaggta tagataatgt agctattatg gaggtaagtg tatttgatac tttttattat 165780 gatatgaagg gaaacaacta gtcccaagct acaatttatt aaggtaggct tagcttatac 165840 gccataattt ttatgtttgc aactttcttg attttcttcc tctggcttta cttctatggg 165900 atatttatga aaggatgttt ttaaaaatgg ctagagactt ttgcttctaa gagttgacat 165960 aaacttttcc acaacatgaa caattagtag atgatacact tagatacact cttgaatttt 166020 taaaattgtg gcagtaaaac tgatctcaga gaaggaagaa aatgctttgg ccagctttta 166080 tcaattatat acaacgtgtt tggaagattc agttcctctc gccttctttc tccctatata 166140 atactttttc ttaaggttgg tactattgat gcacttggtg taaacacatg agataatagc 166200 aaaatatgaa tctaggtccc agaaatgggc ttctttcact ctgccacctg ttctgactgc 166260 atttctcctg actttctgta aatcccgggg aggagctgga agagcaaggt gtgtgctagc 166320 ataactttgg ggatgaagta cccttctttt tttctgattt tgttcccaca tctccttact 166380 ggaccaagta agggcatcag tgtcaaactt cctgattgaa gatacatttt tgccctacca 166440 tgaagggctc tgggtaacat ttattgctta taaaatgctt ttttggtggc tactttgttt 166500 ctgaatataa ggcaagataa aaagtttgat tcaagagttt cttgtaaaca ctttgtgtgt 166560 gcgtgtgtat tcatatatgg ctgcacacgt acataagtcc atacataagt acagtccacc 166620 ctccatgttt gtgggttcaa catccatgga ttcaaccgac tgcaaatcaa aactatttgg 166680 aaaaaaatgg atggtagtgt ctgtgctgaa cacatacaga gattttcctt gtcattattc 166740 cctaagcaat ataacaactg tttacagaga atgtacattg tattaggtat tataaataat 166800 ctagagatgt tttaagctat atgggatgat gtgcgtaggt tatatgcaaa tattatgtca 166860 ttttatataa gggacttaaa catctataga ttttggtgtc tgaggagtct tcgaacaaat 166920 cccccacaga tcctgagggg ccactgtata tatatatctt cataaacaca cccacacaca 166980 caaacacacc cacccaccca cacacacaca cacaccaatg tgtatatact tttttttctt 167040 ttttttaatt cgagaccaag tctcgctctg tcgcccaagc tggagtgcag tggcgcaaac 167100 ttgcctcatt gcaacctctg cctcccgggt tcaagtgatt ctcctgcttc agcctcccta 167160 gtagctggga ttacaggcgc ctgccaccat gcctggctaa tttttgtagt tttagtagag 167220 gcagggtttc accatgttgg ccatgctagt ctcgaactcc tgacctcaag tgatttgcct 167280 gcctcggtct cccaaagtgc tgggattaca gatgtgagct accacaccca gttgcaatgg 167340 gtatagactt ttgaaatgtg tactacaaaa tattaacagt gactatctct gaatgatagg 167400 attatggata aattttgttc tttttgcata tctgtatttt tatttttcca cagtaaacat 167460 cttttacttc tgtaataaaa acttcattaa aaaatccatg ctgcaattga ttaattatat 167520 actaactttt ttttactctt ccctcagtac agaaagatta ttctgtattt accaaatctt 167580 tacactttat ttgcaaatca ttttgactgt ctgtttgcaa gaggtcaaat ttgcactcaa 167640 gttcagcttt cgttcattat ccatgagccc aagagaaatt gtgtcaggtg gacatcaggt 167700 agctgaggcc aatacaatat tattcctttg ggttgttgag aaatcatagc agaggaaagc 167760 ctgtgttgat aatagagtac caccaggaat ctaggtcttt acagctgctg gcctgaccag 167820 caagggtaaa atatttcagt cacgcagcca gtgattatta accctagctc tatattccag 167880 agaggaagag ctagcctttt tgggttgtga tctgtcactg attgcagttg cacatatact 167940 agccatgagg tctacacaca tgtgaagagc atgctacaca catagactag atacactgac 168000 tcatcagcct ggaaacagtg cctgaccctc actttgattg tttgaatgtg tcctgaccca 168060 ttaccctgcc tttggatccg ttcctgtttt tttttttttt tttaaagcat tttatctgtg 168120 aattaaaata gtactttcca ttgcttcatt tttttttccc tgaggagttt agctttgttt 168180 aattagaaac aagacaacaa tcattactgg tctggtgcaa tcttgtttag gactcctctt 168240 ttgcttagaa ctatacctgg attagggatc actgtgattt agagtgtgca gtatgaggtt 168300 atttaaatac ttaatagtat atttgaaatg aaaagagtag aaattaaaga ctgaatcatt 168360 taccaagaaa taacagagga gaccaattta cttctgtaag atttagtaga ggctgttccc 168420 ttctttataa ttggctttgt ttcagttacc agttaagtgg ggtgaactgt tattaaaagg 168480 ctatgggtaa ggttacagta gcattcttct aagaaaaact acaggagtag tcactgtgca 168540 gctatctgct ttgtacctgc caatatggca gtagatatgg aagggtcaga aaaacaggac 168600 ttcatgttca ataacttttc ctttttcctt tctttccctt atttttttca tgtcttgtat 168660 gcaagatagc atgcctattc tttaccttca atgtattttt gaatttttaa tccagatcat 168720 attttatcac aatttgtaac atgtagctaa taaaaatggt tattacatga gaacttgctt 168780 tacaaattat agatcaaatt tttatacaaa ttattatgtc accatagaaa aatagttacg 168840 atttatctgt ttagtcttag aaaaattatt tcacatatta gttaaggctt ttagttttga 168900 gtgagcaaaa tccaattcaa actagctttg ggtagaggtg ggggtaaaag agaggaatgg 168960 atttcaatgg aaggtttact tgcgtgtctt ggctaactgc aaacatggca gggtgcaacc 169020 agaccttagt gatcacagac ccagggactc agaccctgtg aggaccttag ccttaccgcc 169080 actcttctcc atgtgtcagc ttcgcgttct ctgtctgcaa gtatgcattt tccctaaggt 169140 gggaagcaga gttggcaaca gctgccaggg ttgacttcct gtggcattct tgcagttagc 169200 aaatattaga gaaggactct gcttggccca gctttgggac acacctctgg accaactagc 169260 tgttctcagg aggcagtaac atgtacagag gtgatccctg gggctcgccc tgtgaaatca 169320 ttgtgagcca atcactacct ccctccctga tgctgatgtc tactatgttt gatgtctctg 169380 aacttccatt tcctcaattg tgaatggcac cctggttcct accttgctgg atagatgtag 169440 tgattagagt tcatgcttaa cctacaggtg ctctgtaaag aatcattggc atcattacct 169500 cttgttggct ctatcccatt ccctatagat atctttctgc tctgagacta agcagagaaa 169560 ataatttaac atttaattat tgtgcttcta aatccacttt tacctcttct ttctttactt 169620 ttctctttat tatttttaat tatttcaaaa ataaaattgt atatatttaa ggtgtacaag 169680 atgttttgat atacatatac ataatgaaat gattactgca gtcaagctaa ttaacatcaa 169740 tctcctcacc tagttatcat ttttgggggg catggagtga gagcacctga aatctctctt 169800 agcaaatttc cagtgtataa tacagtattg ttaaacatag tcatcatgtt gtacattaga 169860 tttctagact tgttcatgct acataactgc aactttgtac cctttgacca atacctctct 169920 attttctcca ctattccatg cctgaaattg tgggatatag gtatatagtg tgtgtgatat 169980 atatagaggg agtgatatat gtatatataa ttgtgtgata tatatgtgtg tatatacaaa 170040 cacacagaca tacacacatg tacatatgta tatacatgca cacatacaca atgggatatt 170100 attcagcttt caaaaaggac atcctgccat ttgcaacaac atggatgaac ctggatgaca 170160 ttatgttaag tgaaacaagc tggacacaaa aagaaacatg caccttactt cttagacaca 170220 aatttctttc tcatagccag cacctgaaaa tagggccaag tattttgcat gatttacaat 170280 tgactgtata aatgtagcat agccagttat atgatgtgtt accatttctg ctataaaatc 170340 aaaagaagag atcagaacat ttaaaaactt ccctgtggat ttctacctct tacctaagct 170400 ttgttcttgt ttttttaaac ctcatgaaca cgaagcttta gatagcggag gtcatgtatc 170460 cttgggctca aatatacagt ttcttagcaa tctttgattg ctacattgcc cttttttgtg 170520 tttttaactg gccttccctg acttaaaata tactttaaaa aataacaaag gtggtattta 170580 gtttgcacag tatggaatta aaggtaaaca actttaaatt aaatttggtt ggatgtataa 170640 attattaaaa tatcctttct ctcatggctg ggtaagtctg cattttccat tcagcctgct 170700 atgtctcttt ccatgagaac actcccgaag aatggggccc tgcttccaaa caagccaagc 170760 attttgtagt aaattttaaa aagctaaatt tcataataac ctttataatt gctacctgaa 170820 aatggagttt ggaatggcac caaattatta atcagtagaa ggagaataga ttgcaaaaag 170880 gtaattatat caaattgaat gcttcttgaa atatattctg ttaaataaaa tacagttcct 170940 cttccctgtt ctcatttgta agcaatgagg acaattcagg tagcatgaat caggaatcag 171000 agtacttttc tgttccgcag attggcttaa tcattttggg ctcacttcaa actgtagatg 171060 agcattgtcc tttaacctgc cgggcagcag aggtgaccac gttcactgca aagcccagaa 171120 gtgagttgtt catctgggtt agggtctcag gaagaggcat gttatgactt ccccacattc 171180 ctggacagtt tagactgtaa ttcttggttg tttaaaaagg tgtttgaatg tattttgttc 171240 agaggcttga gtaaatggct cttattctta cacttttttt tttgcctgct ttttccagca 171300 ttagaatagt ttcagccctg acaattagcc ttatgctgac tggagtggat tttttgcgta 171360 ggaccaagtg ttttgcatga tttacaatgg actgcataaa tgtagcctaa caagttatat 171420 gatgtgaaga aaattactta agggtaaaaa tggattgttt actgagaaaa tgatgttatt 171480 ataaactggt ttgagggtat tgtggtttag atgctgtcct tacaaatttg agctctgttg 171540 gtttggagat ttaatatcta ataataatag ttaatgtgta atgaatactt gccctgctcc 171600 aggctctatg ttacgtgtcc tgaatgcatc atctcattta atcctccata aaatttgaag 171660 cagtcagcat tgtaattaat ctcacttttc agatgaggaa accaaggtat gtaagaaaca 171720 aaaccagtgt tgaatctgac tagtacgact gcaaagcctg actcttaacc attgtgttct 171780 gttgccttct ccaagggaaa ggagtgcttc cagaaaggcc attggaagtg aggagtgtca 171840 cctgataata gctggctcct catcccacta ggttaacagg caacagatgg gggccacaga 171900 gttggctgga gttagtcctg gttgccaagg gtaaatgggg ctgttaccat gcaatggata 171960 gaaactagga tgctcctgtg tgtctcctta tatcctacca ggtgtagcat gaaggttaag 172020 gacaattccg tcctcttatt tggagaggag accaaggccc tgtaggacta aaggtttggg 172080 tgagctgaaa gccaagggca attggcccag cttggggagg agagttacaa atacatttgt 172140 gactatcaga ccagaaacag actgcggtgt tcacctgcgg tttgggtacc tgctgcttgt 172200 tctttgctgg ggtatctgaa gactgaaaac acagctcaca cttagccttt ttcctattct 172260 gtgtgaaaga actgtagtag ttttctcttg cttaacaagg ttctagtggt gaagtttatt 172320 gcttagtctg tgagttgtag ggaaataacc acaggatggg atggtagcag aacgagaaaa 172380 gaaaagaaga ttgtagatgc caggctggtg tcggcttgaa atttttaaag tatacagttc 172440 ttctttatgg attattaaaa aaaaacagca aatgaataca caagattaaa tgttaagcag 172500 tacaacattg tacatgatga aaggttaaag tctttctctg gtctcattca aaaatctaca 172560 gtctcttgta gtatagtttg aagtcaggta gcgtggtgcc tccagctttg ttcttttggc 172620 ttaggattga cttggcaatg cgggctcttt tttggttcca tatgaacttt aaaattctgt 172680 gatgaaagtc attggtagct tgatggggat ggcattgaat ctataaatta ccttgggcag 172740 tatggccatt ttcacgatat tgattcttcc tatccatgag cgtggaatgt tcttccattt 172800 gtctgtgtcc tcttttattt cattgagcag tggttttgtg gttctccttg aagaggtcct 172860 tcacatccct tgtaaggtgg attcctaggt attttattct cattgaagca attgtgaatg 172920 ggacttcact catgatttgg ctctctgttt gtctgttatt ggtgtataga atgcttatga 172980 tttttgcaca ttgattttgt atcctgagac tttgctgaag ttgcttatca gcttaaggag 173040 attttgggct gagacgatgg agttttctag atatacaatc atgtcatctg caaacaggga 173100 caatttgact tcctcttttg ctaattgaat actctttatt tctttctcct gcctaattgc 173160 cctgtccaga acttccaaca ctatgttgaa taggatggta ctggtaccaa aacagagata 173220 tagaccaatg gaacagaaca gagccctcag aaataatacc acacatctac aaccatctga 173280 tctttgacaa acgtgacaaa aacaagaaat ggggaaagga ttccctattt aataaatagt 173340 gctgggaaaa ctggctagcc atatgtagaa agctgaaact ggatcacttc cttacacctt 173400 atacaaaaat taattcaaga tggattaaag acttaaatgt tagaactaaa accataaaaa 173460 ccctagaaga aaacctaggc aataccattc aggacatagg catgggcaag gacttcatgt 173520 ctaaaacacc aaaagcaatg gcaacaaaag ccaaaattga caaatgggat ctaattaaac 173580 taaagagctt ctgttctttg ctggggtatc tgaagactga aaacacagca aaagaaacta 173640 ccatcagact gaacaggcaa cctacagaat gggagaaaat ttttgcaatc tactcatctg 173700 acaaagggct aatatccaga atctacaaag aactcaaaca aatttacaag aaaaaaggaa 173760 ccccatcaac aagtgggtga aggatatgaa cagacacttc tcaaaagaag acatttatgc 173820 agccaacaga cacatgaaaa aatgctcatc atcattggcc atcagagaaa tgcaaatcaa 173880 aaccacaatg agataccatc tcacaccagt tagaatggtg atcattagaa agtcaggaaa 173940 cgacaggtgc tggagaggat gtggagaaat aggaacactt ttacactgtt ggtgggactg 174000 taaactggtt caaccattgt ggaagacagt gtggcgattc ctcagggatc tacaactaga 174060 aataccattt gacccagcca tcccattact gggtatatac ccaaaggatt ataaatcatg 174120 ctgctataaa gacacatgca cacgtatgtt tattgcggca ctattcacaa tagcaaagac 174180 ttggaaccaa cctaaatatc caacaacaat aggctagatt aagaaaatgt ggcacatata 174240 caccatggaa tactatgcag ccataaaaaa ggatgagttc atatactttg tagggacatg 174300 gatgaagctg gaaaccatca ttctcagcaa actattgcaa ggacaaaaaa ccaaacactg 174360 catgttctca ctcataggtg ggaattgaac aataagaaca cttggacaca gggtggggaa 174420 cattacacac tggggcctgt tgtggggtgg ggggaggggg gagggatagc attaggagat 174480 ataactaatg taaatgatga gttaatgggt gcagcacacc aacatggcac atgtatacat 174540 atgtaacaaa cctgcacatt gtgcacatgt accctagaac ttaaagtata ataaaaaata 174600 tttaaaaaat ctacagtccc tttctcaata ggtaaacact attaacaatt tcttctgaaa 174660 attacatatg tacacacaca cacaccccac acatagatat tttgttaaca tacattacct 174720 tatgctctac acattattct gtgcctagct tttctcatcg aataatgtgt attggagatc 174780 tttccatata agtacatatt ggtctcactc attcattttt aatggctgta tattagtcca 174840 tagtatggag taataatacc ttttattggc acaaagtttt gcagttgaca aagggtttgc 174900 atatattgtt tcattgggtt gtatagcagt catcaacgga catatcaaga atcccagaag 174960 ggtaacctgg gcttcaccca ggatcgcatg gagcttggga ctcaaacagc taacattccc 175020 taaacaggcc catattcctg caatttagtg cagctgctac aacatttagg taaactcttt 175080 gaaagcagta aaaagatcac caatctggga catcaagaag ccagacgaca aggagacata 175140 gacctcaggt gagtgagaaa agagaataat tgaagtttag aactgaatgg gcactaacga 175200 acaacagata catctctttc ctttcaccga tgaggacctg ggtgtggcct gtggatgtta 175260 agtagcatgt ttaggccaca cagctggatt gttttctttc ctgaggctag ctctggagag 175320 gggaggaaac ggagatgcta gatttttccg ggctctcttt tctcatcagc tagaatggga 175380 tgtggatgga atgcagcttg agaagccaaa cacccttgag aaatgagaac tctgctttct 175440 gatgtggggc gcatcctatc tgagataact ctcctgccag cgcagtatga ccattgcgac 175500 ttgagctgtg tgggtgccca ggtggtgtag accttaaaac cactcctgct tttgtttact 175560 gaatgtctaa tattcacaca gttctttgtc tgagtgcagg gccaaagcag caaataacga 175620 agaagctgtg cccaaccata agaactatga aatgctccag atcatctacg ctagtttgag 175680 ttaaatttac catgcaaata aatatagaac atttcttctt atgcatagat tgtatttgtt 175740 ctattaaaca accatcctgt aaaggtttta ttcattcatt tatttttatt tgttaggaga 175800 aattgttatt taagctaaga aagtagacta gtagttattt cttttttttt gcttattata 175860 ctttacgttt ggggatacat gtgcaggtta gttacgtagg tatacacgtg ccatggtggt 175920 ttgctgcacc catcaacctg tcatctaaat taggtatttc ttctaatgct atcccttccc 175980 tagcccccca ccccctgaca ggccccagtg tgtgatgttc ccctccctgt gtccatgtat 176040 tctcattgtt cagctcccac ttatgagcga gaacatgcag tgtttggttt tctgttcctg 176100 tgttagtttg ctgagaatga tggtttccag cttcatccat gtccctataa aggacatgat 176160 tgcatccttt tttatggctg catagtattc catggtgtat atgtgccaca ttttctttat 176220 ccagtctatc attgatgggc atttgggttg gtttcaagtc tttgctattg tgaatagtgc 176280 tgcagtaaac atacgtgtgc gtgtgttttt agaatagaat gatttataat cctttgggta 176340 tatacccagt aatgggatgg ctgggtcaaa tactagaagg ctacagtaac caaaacagca 176400 tggtactggt accaaaacag atatctagac cactggaaca gatcagaggc ctcagaaata 176460 atgctacaca tgtacaaccc tctgatcttt gataaacctg acaaaacaag caatggggaa 176520 aggattccct atttaataaa tggtgttggg aaaactgact agccatatgc agaaaactga 176580 aactggaccc cttccttaca ccttataaga aaattaactc aagatggatt aaagacttaa 176640 atgtaagacc taaaaccata aaaaccctag aagaaaacct aggcaataca attcaggaca 176700 taggcatggg caaagagttc atgactaaaa taccaaaagc aatggcaaca aaagctataa 176760 ttgacaaatg ggatctaatt aaactaaaga acaactgcac agcaaaagaa actatcatca 176820 gagtgaacag gcaacctaca gaatgggaga aaatttttgc aatctatcca tctaacaaag 176880 ggctaatatc cagaatgtag aaggaacttc aacaaattta cacacacaca cacacacaca 176940 cacacacaaa caaccccatc aaaaagtggg tgaaggatat gaacagacag ttctcaaaag 177000 aagacattta cactgccaac aacataaata tgctgccaac aagcatatga aaaaaagctc 177060 atcatcactg gtcaagagaa atgcaaatca aaaccacaat gacatactat ctcacaccag 177120 ttagaatggc aatcattaag aagtcaggaa acaacagatg ctagagagga tgtggggaaa 177180 taggaacgtt tttacactgt tggtgggagt gtaaattagt tcaaccattg tggaagacag 177240 tgtggcgatt cctcaaggac ctacaattag tagttatttc taggtctgac gggctgtctt 177300 ttagtttgtt ttcttattct gaggtggact taaaccaatt ttaaaaacag ggatgactga 177360 attcgtgtgt taatcttgta ctacaggaac cctttgacat tgattcagaa gcacccaagt 177420 gtttgttcat taatcctttt ttatttttgc atattattta tttttcaact tttattttaa 177480 aaatcagggg tacatatgca ggtttgttac aaaggtatat tgagtgatgc tgaggtctgg 177540 catatggatg aatctgtcac tcaggtaatg agcatagtac ccaatgatag ttttttgtac 177600 ccaatgatag ttttttgttt tctttgtttt tttttgtttg tttgtttttt gagatggagt 177660 ctcgctctgt cacccaggct agagtgcaat ggcttgatct cggctcaatg caacctccgc 177720 ctcccagatt ccagcaattc tcctgcctca gcctcccaag tagctgggac tacaggcgta 177780 caccaccatg cccggctaat ttttgtattt ttagtagaga tggggtttta ccatattggc 177840 caggctggtt ttgaactcct gacctcaggt gatctgccca cctcggcctc ccaaagtggt 177900 gggattacag gcgtcagcca ctgtgcctgg ccccaataga tagtttttca gtccttgccc 177960 ctgttcctcc ttcccacttc tagttatcac cagtgtctat tgtttctgtc tttatgttca 178020 tgtgtaccaa atatttagct cccacttata agtgagaaca catggtattt ggttttctgt 178080 ttctatgtta gtttgcttag atagacctcc agctgcatcc acgttgctgc aaatgacacg 178140 atttcattct tttttatggc tgtgtagtat tccgtggtgt agatatacca tatattcttt 178200 atctaggata actgatgggc aattgggttg attccatgtc tttgctattt tgagtagtgt 178260 tctgatgacc atatgggtgc atgtgtcttt tcaatagaac aatttatttt cattactctt 178320 atcaggatac ctgggaggaa cttctcctac gaagttaatt tggggggact cctgaagatg 178380 agtgaaaccc cttattaagc acttagaggg tcgaaagtgt acaagggaac gttcaggtgt 178440 gacagcttga gagacatgca tattccaccc ccacaccaga gcttagtgaa ccgtcttttc 178500 tattttctcc caaagcacca aaatggccca gaaattggaa gatggaaaat ggacttattt 178560 atgagtctgg gaaggcaggg cagtaagcac agtcctgttc agggttctga gttttaccct 178620 cttgctctga ttgcgagatc attttcctct tccttgcttc ttcagcttag gacaagaaca 178680 gtttggaaat tgtttctact actttggaca ccatagttta gatttcaaat gagtacaagt 178740 gggaggaaag cttggataat tctctggaaa taatcgaaca gagtgaagga gaggggtcta 178800 caggtgagct gaatgctgca tggcattgaa gtaatcacac cagtcgtcac aattctctcc 178860 tctttgatgg ttatctgttg tcccagaagg aacaatttca gaaagtcctt ttctggactg 178920 tagaatagca cttgcttatt tgatgagccc tgagaagcat tactgaaagc ggttcattgt 178980 ccctgaggta ttacaatgag atggtggtca ctgatttcat tatgttttcc tttattgcag 179040 ctgttggttt gatcctttgc caggtgctta aaacaattgt ggttttgcag atggtaagtt 179100 agaggttgga caaaaaaagg gatcatgtca ctgccctggc caaaatttca acagactggg 179160 gtctagtgag ggcaaataga tagaggcttt cctcttcact ttgtgttatt tagaaaaaga 179220 aactttccag gacaaatttc tttcctagaa ttcctttttt aaaaattttt tttctttgaa 179280 aatttactta gatgcaaata atatattttt cttcctttta aataataaaa gtaagatgtc 179340 tcttggaggt ggtggttgtc actgacaaga ttaactagaa ctgactagct gtaaaaatat 179400 aatttgggat gcattattaa ggcatgccat ttttatttgc atgccattgt gtacagatgt 179460 ggttgtgaaa tagttcaaat catggcacat tgaatgtcct cactggattt ttaggaatgt 179520 gttcactgag acagccaaat cctatttcat tttctttggc tcattgcatt ggctgtaaat 179580 tggagatatt cactttaata tgtgagtcaa aatttatttc caaacataat actgcagttg 179640 ttctgtcaca gaatataaat ttcttattta tttccttaat acgttgcttt ctactttttc 179700 tttttttctt tattttattc tggagtatgt ggaaaggttt tccagaaaga tttgcatatg 179760 ccataatcta ctgatgaata ctttttttgg gttactcttt catattttgg gagatataac 179820 tatggaagtg ttaggaatca tgggttctgg aaatagtttt attactgctt ctgaaatgcc 179880 ctcccaatga taccatatag taattccatc agggaataat atttttatta tagtttaaaa 179940 tataacttaa tatttaggtg ctcttgttca gtcatcgtca agttcttttt atttcaccaa 180000 ccctaccatg gcactcctga aagacttgtg aatgcgacag acctggattt aatcatggct 180060 ttgccatctg ctagccaaga gaacttgaac aagtgagtca acttcttgga gtctcatttt 180120 ctgcttctgt aacatgggaa ctagggtaat ctaactcatt gcttgtgatg attagatgag 180180 gcaaaatgct gagttcacct agcccagcac ctggtccatg ggaagcatgt gggttctgct 180240 gctacccagt ccttggccca gtgcatggtg cacagaaggg aatctgaaca ggccaacttt 180300 attcctattc ttgacccacc ccatgtagat gcttcctaca tcttcagctt cttcttcttc 180360 ttcttttttt ttttaaggca gggtctcact ctgtccccca ggctgaagtg cagtggcaca 180420 accacagctc agggcaacct cgacctccta ggatcaagtg atcctcccac ctcagcctcc 180480 tgagtaactg ggatgacagg accacactac cacacttggc taatttaaaa acttttgtag 180540 agctggggtc ttgctatgtt gcccaggctg gtctcaaact cctggattca agtgatgccc 180600 tcacctcagc ctcccaaagt gcctggaaaa caggcctcca cacccagcct tcaacttcat 180660 tttaaaaaat tgtggtaaac tatacaattc atccatgaaa gcagaaacca cttgtacccc 180720 aaaagctatt gaaatttaaa aatatatata ttaaaaataa aaataaaatt gtgataagat 180780 atacataata tgaaatttac tactttaatc atttttaagt gtacggttca gtggcattga 180840 gtacattcac atttttgtgc aaccggaact tttcatcctc ccaaagtgaa gctctgtact 180900 tattttttat tttattttat tttttgagat ggagtttcac tctagtcgcc caggctggag 180960 tgcagtggtg caatctcggc tcactgcaac ctctgcttcc tgggttcaag agattctcct 181020 gcctcagcct cccaagtagc tgggattaca ggtgcccacc accacaccca gctaagtttt 181080 tgtattttta gtagagacgg ggttttgcta tgttgggcag gctggtctct aactcctgat 181140 ctcaggtgat ctgcccgcct cagcctccca aaatgctggg attacaggca tgagccactg 181200 tgcccggcca gctctgtgct cattaaacaa tgactccaag ttccccttcc ccacatctcc 181260 tgctgacctc tcttctactt tctgtctctg tgagtttaac tattctaggt acgtcatgta 181320 agtgcatcta tgtgatattt gtccttttgt gtctggctta tttcacttag cataatgtct 181380 tcatgattca ttcatgttgt agcatgtgtc agagtttcct tcctttttaa ggctgaataa 181440 tactccactg tatggataga ccacacttta tttatccatt tgtctgttga tggacatttg 181500 gatgatttcc atcttgtggg tatactgagt aattttgcta tgaacatggg tataaaaata 181560 tctatttgag tttctgcttt caattatttt gggtctacac ctcaaagcgg aattgttgga 181620 agtggaattg ctttccactt gttggaagtg gaacatggtc tcccacttca ttttgacaca 181680 acttccaagc ttcagaactg tatttacaac agcgtgctgg gaggtcgctt tgagtttatg 181740 acggaaatct catatcaaca ggttttaaat tgttccatac gacttcttgc cacccctgtc 181800 ccaattcaga tctttttttt gattaatggt atgaacaatt ttcaaaatat cctggcacaa 181860 tctattagaa tatttgactt tctcctcctc ctccctttag ccctaactat ttggcaaagc 181920 tgttgaaaac ttcttcacat cttctctctg cctcatctac tttgctactc aaagatgatt 181980 agtagatgtt ttggtatgat tttttttcct tggcataact gtgaatactt ttaatccttc 182040 atgttttatg acaatcatac attcccactt ttgtgtaaaa acattttgaa ttcttctttc 182100 tataacaaat tctttgccag tcttcctttt ctttttgctt ttagtgagtt ccaatgatat 182160 cattgtttga acctgttttc taattctatg ctgctattcc catactccct ctttgctttg 182220 gttacagtag ataatgtggg tggtcctacc aagacaaagc atcactcagg agtcaagggc 182280 tggggtagat acagacacta ggtactgcag aaagtcaata tctttctcag agtgtaaggc 182340 aggacaagac ttctgttccc ttgtaccgtt gtggctgggg agttggactg tgcatttcat 182400 ccttgtcata taagtcaaag tattgcccaa ataacttaat tttggtgtgg tcttagtaag 182460 tatttgtctc gtagatatgt taaatagaag acagtaacat tgggttggct gtgttaattc 182520 ctcacttttt ctttcctata catgagcttc ctaagaagcg gaacacttgg tggtcagaca 182580 gttgcagaga ttccttgcat gattgcaatc tggaaagtag ataccattct tgaatgaaga 182640 gcttgccctt tggagaagct gggctttcca tatatggagg ttgttagaat gcataagagt 182700 tcagcttctg gaatgaaagg agaccttggt tcaaaaccca tctgccactt gcttgctgtg 182760 tggcttaaat caggctttta aacttcaatt ataattttgc atctgtataa taggattaat 182820 ataattcctt cctcataaag ttcctagggg gttaaatgaa acaatcaatg tataacacac 182880 ttcctggcat gtgatgttca gtacctagaa gactcggttt ccttggtaga gagaatattt 182940 ggctagacaa gcttatggaa ttacccccag ataggaagtg agcacaagtg tgaaatgaac 183000 aagccagagc aggaacggct cttggaagcg tctactcagg cctgggcagt tgctggttta 183060 tataacagtg ctttgaaaat tcacgtgcag attcttacta ttttcccaaa tgttacagct 183120 caaaactatg ttgtctgtac cttaacacct aaaggataat atagtctttc actgataaaa 183180 ctaaaatgtc ataggttttc ctttggccaa atatgtatag aaacttgtga tttcacatca 183240 gatttaaagc tgtatttaac actctatgaa aacatactga tgcttagaag tagaaaggaa 183300 gtcagatttt gacatcttac ttgtcaactt aaattattta tagttcctgg atgcttcaaa 183360 atgtgataaa ccatagttaa ttttatgtaa atattcgatg agtgccttta ataaggagac 183420 tgtaaaggta gccaagcttt atatatgtta gctacattta tgggtcaatc gggtataaaa 183480 aataggactt cgaaaataaa atattatttt gtcggactcc tccaatgagg ctttttcgca 183540 ggattagcta aaattggctc ttatttgatg tgtgagtgct taaacattgg agaattcatt 183600 tttcttttag aattcatttt tatttctgag ccttaaaata tgaacagtta gctaaatgtt 183660 tgtatatgtt gataaggaat gctaagtgtt tattccttaa tgggacgaca ccttttcccg 183720 gtttacataa cttgcctttt aatctaacct tatgaaagtc tccttgactt taattttttt 183780 tcagagtact gtatatctct ttagggaatg catttattta aaaaattata aagcaagaat 183840 agatgtgata tattttgaag ttttctagtc acaaattaaa tccctagatg tgttgtagtt 183900 tgtggagcac tttgaaatgt gccaattcaa gatggaaata gcaggaaaga accattcaag 183960 tacgatttct gactccataa agttaggaag ttatgataaa ggaaaaataa ctacaccaca 184020 tacttatggc acagaattgc attattggga caaattgatc ttcaaatttg taggctatga 184080 tggaagcaaa tatttgtagt atcttaatat tcaactgtta agccaggaga cgagtactct 184140 gaacttcagc ttctcataaa atcagtcagt tacatgacag tttatgtagt ttatatgtaa 184200 gaaacccttt gatcaagata tgccttttct tcagccttgt taatacttca tttataagga 184260 tttttatttc taggaaaata ataccataga cctattttat ttaaagctaa agtgtttcct 184320 ggtgatggtg gtgaatgggg agatgattca aggaaactgc taatcttgta gagtttagta 184380 aaatcttgga atagaaattt taaaaagtta aaacacacta tgaaaacaaa tcattattag 184440 taaaatgaac catattaaaa tgtctccata accaacgtat tatagcaggg gaaaatggca 184500 ttttaattca gaaaaacatt tctatataaa acaagctttg gaataatttg aatatgttga 184560 tttttctttg gggcaatcat gaaatacagt catattagga aagaggcaag gcctcaaaac 184620 ggaaagagta gtgaggataa ttcatgagca atgcgtggct tcatggatcc cttcctggcc 184680 ctcttcatct atgaacatct gctttatgtt catgtctggc ctcacccagt gctgaagagc 184740 agactgcccc tgcttagaac caagccttgt tcttgtggat ttgagttttg gggtcctgag 184800 gtagaatggc catcatattg ttcagggtcc tcaccttccc actcattact tcctttatag 184860 aaccccagtc atccccctca ggaggcctgc gctccacaaa tgaagttggg ggtgagggga 184920 gctttagcat ctcagtattg ttcagatatt ggatacttgt tgagctccac tatgtgtgtg 184980 agaatgcgct gggctcagga tcaatagcca taaatgagac agatatggcc catcccttgc 185040 catgcctaaa ctgatctggg cattgagaca agcagttaaa acccaacata gtaagtccta 185100 tgatgagaca caaactaagc atggctggaa gggcagataa gatttcacag aggaactgac 185160 atcttgactg gcacacttag aagatgagta ggagtcagtt gggccaagag gagaaaaagt 185220 gtgtttccat gaagaagaag agcatgtgcc aagtcctggg ggtgagaagc atggcatgtg 185280 tcaacagaaa gacatgatca gagcttggat gggagttaga gcggggagag aaggcaagga 185340 aaaacataag agctttgcaa actgtgaagg cattgcattt agatgtcatt tttagagctt 185400 ggaggagcct caggacattg aggcaggata gtggcctgat ggcgtatgat tttaggaaaa 185460 atcactgtgg ccaccctgtg gggaaggatt ggcgggggaa ggctggaggc aaagggtcct 185520 gcggtgggct gtggtaatga tctgggctgg agaaggtatg gtggtgccca gcgcaaaatt 185580 ggtttcgctt tgaaaaataa ttagaaaata tttgttttga tctgtgtgcc tgtggtggga 185640 ggtggggagg gagggtcaag tgaggaagga gattgaatct agaataatgc ccatgtttca 185700 ggcttcacgt gcagacattt cttggttcag ctgggaagtg aataggaaca gactggcgag 185760 gaaagaagac agtcgtcagt tctgtctggg gcacatccat cttgacgagt gtgagagagt 185820 caagtcttga tggacagggg caggtggaca ttcaggaaac tcaggaaaga gatttgatct 185880 gaagtgacca ccagaaaata ctgacggaaa agaggtgaca aaaggagaga cctgcaatat 185940 tatattggct ttctctcagg caactgcttg gcctgtcttt atattccttt tgaatctctg 186000 catatgtacg ggccattatt tattttcaca actaacaaat gcagactttc tgtgtaatga 186060 caacaaagcc aaaccagctg ctaccaaagg agggaaaatc agaagagaag gaaaaagaac 186120 aagggaagct tggggaaaag ctgaatgtgg gtccttctgt tgctgcaggg gctggggtgg 186180 gcccggtgat tcctactgag aggcgttttc tctccccgct tcctgtcttt ctggttccat 186240 ctcattcacc tcctgtcccc tccacttcct gccagtcaaa ccttagattc ctccagaggc 186300 tttttatttt tatcttttga tgggcaagaa aatagtgcgg attatttttc caaaccttca 186360 cctgaacatc acatcgtggc tttggcccta tgggcttggt tcatccgggc ctgcacagaa 186420 ggacttttcg ggccagtctg gtcacataca tcgagtcctg tcttttcagt taaaaaaaaa 186480 cacacacaca cacactgcta tgtttcacta agacaactgg tgtgagttgt tttttagaaa 186540 atcaactcta cttcagtaag attttctcaa gcattatctt gagaagacca gataataaaa 186600 tttaaaaaga atttcttctt ttttttttat tatactttaa gttttagggt acatgtgcac 186660 attgtgcagg ttagttacat atgtatacat gtgccatgct ggtgagctgc acccactaac 186720 tcgtcatcta gcattaggta tatctcccga tgctatctta atgcaactta aatcaattgc 186780 tttaataaca catattgacc aagttacact cattaaggaa aaaaaactac tttgttgttt 186840 ttcttcttct gacgtgagct gaagacttag aaatagttgt taatagtgtt tggttaataa 186900 gaatttgttt taattgcata tatcaaatat gtatttatta aacttttctt tttgtcagtt 186960 tatcaattct agctttgtca caaaaggttt gccgtatgaa catgattctg ttgtacatct 187020 atttccattt ttgttaagag acgaattcaa ttgtaaaaat ctagtacctt ttattcatta 187080 aacatgttag ttcaggaatt tcacttggtt ctacaaagat acatatctac agtggatggc 187140 cagtgcaaac atgagactca gccaactggt ctctgaccca attcagttct cctgtcttct 187200 tctggcttac aaagtaactg gctctgggga gaaagtgagt caaagtaata tttggtttga 187260 atggttattg actattttct tctgaaactt aatgtatact aattaatttt ttattttatt 187320 cttttttttt tagagatagg gtctcgctct gttgtccatg ctggagtgca gtggtgctat 187380 cacagctcac tgcagccttg acctcctggg ctcaagcgat tctcctgtct cagcctcccg 187440 agtagctagg attacaggca tgtgccatca tgccaggcta atatttaatt tttttttttt 187500 gtagagacaa gatattgtta tgttgcccag gctggtctaa aactcctggt ctcaaactat 187560 cctcccacct cagcttcctg aagtactgga attataggca tgagctgcca cacctggcca 187620 tatactcatt ttttgttaaa agctgaaata tatcagcata tactgcataa ataccacagg 187680 agactaaaca ctgaaagttt ctttagggta tcagaagaat acactttttg cttgcagtta 187740 gcatctgcac agataagttt tgtttctggt tctattactt cttcagtttg accctattaa 187800 taaggacaat tctaaaaata ataactgtgt ctggatatct gaatccgtgt gtggtctttt 187860 actgaagtta caggtttata actctgctga ctagtttgct ggtttctgtt atgcaataga 187920 agagtgcaaa tgttaatttg atctgaagcc cgtgtataca gtgactttta taatgtatat 187980 ttaaagatgg aaagccaagt tttatgaggc cagcatttct tgtcaagtcc tcactccacc 188040 ctcttctaat tgggcctgac ccttaagttg aataaagaac aaagagctct gtagttaaaa 188100 catttcactg catgttgcat cttgccctta gtaaatggaa aaaaatagag acttaagcag 188160 agaatctgaa ctagggtgtg aaatatatat tcagttttgg ggtgggagaa tgagaaccat 188220 gttttacaat agtatacata acttccttag tctaaattca ggacatttcc ccaagatatg 188280 taagaattta gacttatgca gacagacttt ataaaaacat gccaatattt attagtttgt 188340 gaattttaat attctgctcc ctataaacca gatttatttt gagggataaa gggatggagg 188400 tgacttctaa atcttagagc agaaacttcc tgtgggcagc tggacatatg taccaggagc 188460 tcagagaaga gggttgtgtt gggagcgtac attctgagtg atctgcattt ggtgatgatg 188520 gaagccatgg acatgcacta gattgtcttg tgggagaata tggagtagta agagaagaag 188580 aagacctagg attgagccct gagcacctct ggcttaatgt tggatggagg aaattgaatc 188640 tgtaaacaat accgggaggc tgcagcctga gaggcagaag gaactggggt gtttgggatt 188700 atggaagcca agggaaaaag cctgtctcac agcgggaagg gaggtatcaa cattgtaagc 188760 tgcttcagat aggttatgta ggatgtggac tgaaaaatac ctgtaaaatt tggcaacgcg 188820 attcattggt aatcctaggg aagttgcttt tttggggtaa ctaaggtgga aaacagattg 188880 gtgtgggttg agcaatgcaa gagaggtgaa gaaaaggaga tttcatgtgc agacgtttct 188940 gagttcagct gggaacaagg gataagatag aagatggaag ttagagagca tgtggggcaa 189000 gggagactct tttatgggac agtctcgcat gtgatcaaag ccaatgagta aggagcattt 189060 gagggagaga gagtcaatca acaagagaga aaagaaagag ggttcatcat aaaataacgg 189120 taacaacaac gaacatcttt tgagtgtttt ctatatccgg ggaactatgg taaactccta 189180 acctgcattc tcacattcaa ttcttagaat cgttggatgt ggtgggttcc atgatttcct 189240 ctagattagc gaggaggaaa gagagatcta gaaatgtcag gtagcttgct cagagttctc 189300 caggtagtca gtcatggact aatttgtgaa ctgaaggact gaacttcgtc accacccagc 189360 ccaccaagcc ggcttgactt taggtattct gtgctgcatg tgagtaccga cttaaattat 189420 attttaagaa gggctacttt gaaactctct ctctgaaaac tctatttcta aaagctctac 189480 cctcacaaca attttggcaa gcagtcttgg taaaaccaaa ccaaaccaaa ccaaaaccaa 189540 aaaaccttat ctgctgagaa aatataacca cataaaatat ggtgctacaa aatatagact 189600 gtgtgaactg aaggtgactt gcccaaagga ctcctgaagc aattggctgc tgtagaaatt 189660 aagtccacgg gaggtttttt gttctgtttt tttttttttt tttttgagat ggattctcac 189720 tctgttgcct aggctggagt gcagtggcgc aatctcggct cactgcaacc tccgcctccc 189780 gggttcaagc gattctcctg cctcagcttc ctgagtagct gggattacag gtgtacacca 189840 ccatacccag gttttttttg tatttttagt agagacgggg tttcaccatg ttggtcaggc 189900 tggtcttgaa ctcctgacgt cgtgatccac ctgcctcggc ctcccaaagt tctgggatta 189960 caggcatgag ccaccgtgcc cggcccatga gaggttttgt ttgcacttca agaaggacag 190020 aaaaaggcag gcaggctggg gagcaacata gtaaggctga ggaagtgata ggaaaacagc 190080 ctccaaaagg tttccctgta gattctgact ggctaagttt cctgaaataa tattaattct 190140 gtcctcttgc ttttaatagg acataacgac tatatgtgtc cagccaccaa ccagtgcacc 190200 attgataaaa acaggaggaa gagctgccag gcctgccggc tccgtaaatg ctacgaagtg 190260 ggaatgatga aaggtggtag gtacatctct cccaggggcc cttggggatg gccctggcca 190320 ccgcccagtg ctggctctac ccattggaat aacaccatgg gaattttgtg tttttttctt 190380 ttaattgttt tttttctatt cttatttttc tttgcaacaa aagtattttc ataatccatt 190440 ttattttaaa aaggtggaag tgtctggaac tggaaattct aacatggcat tttgtgtttt 190500 ggattttcaa tgtaaataat tatattttaa atcaaaggtg tgtgggaggc ggtgatggaa 190560 ggaaacgaag agtgcttagt aaattattct agaaatattt ttcagttact gtttatgttg 190620 caaatgctag aaaatgatat ctgaggataa actttcccta aattgagact tgtaaatgtg 190680 aaagctgagt agctaattta tagccttcca gtctgttatc atcccttaag gaatgtgaat 190740 ttcaatcaaa aggcagtttt ctcctttaga acctgagtga accagccact ttcttaacct 190800 cagtgtctag catggtgctg gcatagttga ttactgagca ctacactaac aagtgtcaga 190860 gcatgcatgg tttgtgactg tgggtttgtg tttttgtggt ctttgtggct gtgtgtgtgt 190920 gtggttttct gtcttctcat gtatccgatc ttccagtttt gtcatacagg aatctggaaa 190980 ctgaatccca gttctgggaa tattaggagc cccataaatg tggttgcctg attgacctca 191040 ttgtattctt gggagtctca tcttgaggaa cattgcttct agtcttggat agccttcagt 191100 gtagtggaag agaacaagta gaaaatgtgt aattaaaata aagtcatgag gctgaggtgg 191160 gcagatcatc tgaggtcagg agttcgagac cagcttggcc aacaaggtga aaccctgtct 191220 ctattgaaaa tacaaaaatt agctgggtat ggtggcgagt gccagtaggc ccagctactt 191280 gggaggtgga ggcaggagaa tcacttgaac ctggcaggtg gagggggcag tgaactgaga 191340 tggcgccact gcactccagc ctgggtgata gagtgagact ctgtctcaat aaataaataa 191400 ataaataaat aaataaataa ataaataaat aaataaagta acggattcat ttagtgtttc 191460 agaaggatac tgaagggagg gaagggctga tgatggtgct acctgctgat tgtaataggg 191520 aaaagcccgt ttcttttctg aaggaggtga agcttggggt gatttaagga gaacaaaatt 191580 tcaatgaaaa ggaatagtga ttttgcaaat agtgggcagc taacctttaa atcattctta 191640 ctgggacgca ggaggaagga gaggaaagac caagaatgga gattatgatg aagacaagct 191700 tgattgttaa caagcttaca gtgacaggtt tcatagtccc ggggtcataa atacgccaga 191760 caggttgagg tttggaatgc agcatttgga ataaattctc ctggtgaaga gatgcaatgt 191820 tgaatttacg cattctgtga gctgtgacta tgactataca tcttgaacat ctgaaaaagc 191880 agctttaatt caaagggtaa ttaattccaa gaatttaaca gctacattca gaaaatgaca 191940 cttgagtcat atggattaaa tatttaagga attcatcttt ctttgtactg ttggagaatt 192000 agtcaggctt aattaaactt acaaaatgcg tcttaaggta acttggtaag tgacaggaat 192060 ataacagctg cataagaaaa gctttatttg aaacagtgga gtcgaggttt aatattcttc 192120 tttggcgatt atatgtaggt taagcacagg ctcttccata cattctcctt gaaagctgaa 192180 ataatcaagt catgaatatg tccaaaacaa tttttaaaat gtgaggggta cccatgcatt 192240 gaccccattt cataaaaccg attctgtttt tttttttgta attaatatcc agatacggtc 192300 tggctgcatg aatataaatt acgcattctc atttttaatc taacaaaaat tcatatatgc 192360 aaagacataa taaaagtctc cccactgttt tctcctagga atctagataa tttgactgta 192420 cacaacagac tgtggatggc tccatacaca cttgcacatg tatattgatg actgtaaaat 192480 atatatctgt attagttttc tagggctgcc ataatgaaat accacaggct gggtggctta 192540 aacaacggaa attaattttc tcccaattct ggaagctgga catgcataat caaagtgctg 192600 gaatatttgg tttctagtga gccctccctt tttttttttt gagagatgga gtcttgctct 192660 gttggccagg atggagtgca gtggcactat ctcagctcac tgaaaccttc acctcccagg 192720 ttcaggcgat tctcctgctt caacttccca agtagctggg actacaggtg tgtgccacca 192780 tacccagcta atttttgtgt tttttttttt tgtagagacg gagtttcact ctatgttggc 192840 caggctggtc ttgaactctt gacctcaggt gatccgccca cctcggcttc ctaaagtgct 192900 gggattatag gcgtgagcca ccatgcccgg cctgtgaggc ctctcttcta ggcttgtggc 192960 tagccgtctt ctgcctgtgt cctcacatgg cctttcctct gcgtccgagc actcttggta 193020 tctctttctc ttctcacaag ccctgttgga ttaggagtcc acccttatga cctcatttaa 193080 ccttagttac cgccaaaaag gccctatttc caaatatagt cataccaggg gctagggctt 193140 caacatacaa gttttgtggg gacacagttc ataacaggct gccctcccaa aataccatag 193200 actgggtggc ttaagtaacg gaagtcaatt gcctcatagc tctggaggct gaagtctgag 193260 actaaggtgt tggcaggttt gatttttccc gaggcctctc tccttggctt gaagatggct 193320 gccttctctc tgtgtcccca catggccttt tctcggggca tccacagctt cttcttcttc 193380 ttacgaagac accagtcata tcggattagg gccccacaca caggacctca ttgaatctta 193440 atcacctcac ttaaggtaca atttccaaat acagtcacat tctgaggccc agggggtaag 193500 atttcaacat atgagtttta agggtacaca attcagtatg tggcaatatc ccataggggt 193560 tactcagtga ttgttcagta tttctttaca tgtaaggaaa acatgtatct ttctggcagt 193620 ttttatatgt acataagttt taaatgaagc tttaaattca taaaattata gcccgtgaga 193680 acatcttatt ttaatgatat gtataaagta cttgccataa atcaatataa tttattgtat 193740 tttctacaac atggaatacc acacatggcc acaggatacc ctctataaca actccttgaa 193800 aaatcccatt gaataaagcc ttaatttaca actggaagta caatgataac taactataaa 193860 atgtgcagtc acatggcaaa ggccagctgt gactgaataa atctttacaa catgttttca 193920 accattaggg ttcacaacaa tccactttct taaccaggct ggttaccaac taggatattg 193980 aaactctacc tatgaaataa aaagtttagt ttcagttaaa agagaaccac agacctactc 194040 cctattttca tagcaaggct gaaaaaattc actgaagatc tattgtaaag atccaaaaga 194100 gtgcatgatt tgtctccatg aactaacaat tttaatctgt tataatactt actgcctctg 194160 aaaatcccag catcattatt agatttggtt ctgaatcatg gtagttctat aagatgcagg 194220 atttgaattg cactttcggg aatgtgcttt tctatcctag tacatgtgct ggtttctctg 194280 cattgctttt tcctcttcat ttgtctcctt cctcttgaac tttaggttgt agattacatg 194340 tctcttcttc aggaaggcct acacagttac ctgacagttc ctgaggctcg aagttcaaaa 194400 tcaaggtgct ggaaaattca tgttctagct ttaatggcaa acagctcttc tcttagctct 194460 tatcaccatt attattagtc attcaatgtc tgtctttaca tatggtccat aaactccatg 194520 atggcgcggg ggtggggggt ctctgtgtct tgtttaccga tcttgcatga aacaagtcac 194580 aaggtaggtg ttcaagaagt atttttttgc actaattaat gaattgattc aattcattta 194640 aatagttatt tgtgtagggc ttcttatatg caaacccttg ggaataaagc aaatatgaat 194700 aagattgtag tcccttccct caatgtcctc acagtataaa gagaacattt gcatgggaag 194760 cggcaaataa aaatctcaac ggcaagtgga gactgggttg caagatggct caaatattga 194820 atgatcagaa tgggagtcta gagctttaaa caaccactcc caggtttagt ccaactcaga 194880 gtattactca gacacctgac atccaagaca tatattatta ctcaagaatg tggccttttt 194940 gctgagtttg gtagaaagag gaactcttcc aaagataaat gtgttcaaat gctggctcct 195000 cctcaaactt gctgaacaac cttgttaaag tcacttttat gagcttcact aatttcaaat 195060 atgaaatgga gataaataaa ttttattgtc caagcacggt ggcttacgcc tgtaatccca 195120 gcactttggg aggctgaggt gggcggatca cctgaggtca ggagttcaag accagcctgg 195180 ccaacaaggt gaaacctcgt ctctacaaaa ttagccaggt gtgatggcag aagcctgtaa 195240 tcccagctac tcaggaggag gaggcaggag aatcacttga acccagtagg cacaggttgc 195300 agtgagccga gattgcacca ctgcattcca gcctgggcaa cagagtgaga ctctgtctca 195360 aaaataaata tataaataaa caaataaata aattttactt aatgagtttg tcatgaagat 195420 gacaaatcgt aacatgggaa aatataaatc taaagtgcca cacaagtgtt agctattaca 195480 tatctttttt gtcttaaaaa taattactat cttagttaaa aatttcatca tatacgagca 195540 ctgctgggtt ttttttttca gctgaaagaa agagaatggc aatttcatca cttctacaag 195600 atataaattt ctaatttctt tgtggagaat aaaaacttgg cttaaacacc taagcttttt 195660 tttcttttct gatctcatat gctgaatata gctgaatgac aagtgagatg tgttatttat 195720 cattttatga tgccagagat ttacacgaat ttgtgaaagg ttttttctta ccatagattc 195780 agaggcgtgt ttgaggcaag gttttcattg tgcagtgagg aaattggcac atagaaatca 195840 attgatgtgc aggactcttg gactgactat tctggttatg tttccttata acacattaag 195900 aagaaatttg agataaagta gtaattgtca actagtcttt atttatttta ataacaaatg 195960 ttgcagtata atttttagaa atattccaaa ataacaaata aatccaaaaa ttaacgggat 196020 aattttaaag tgagaaaata acatactact aatatagaca gggaaatata catgtgtcca 196080 gaatgattca gaagcccaat gaaacactgg aaaataaaat attttcctgt tgcttgggtt 196140 taatatttat cactatgagt tatcgtaatt tgctttattg atggataaac tcccaacctg 196200 gggactgcga ttggaatcct ctttaatcct acattggcta tcctttatca aaagtaaaca 196260 accggctggc catggtggct cacacctgta atcccagcat tttgggaggc cgaggcgggt 196320 ggatcacctg agatcaggag tttgagacca gcctgaccaa catggtataa cctcgtctct 196380 actaaggata caaaaattag ctgggtgtag ttgtgcccac ctgtaatccc agctatttgg 196440 gagcctgagg caggagaatt gcttgaactc aggagacgga ggttgcagta ggccaaaatc 196500 acaccactgc actccagcct gggtgacgga atgagactcc atctcaaaaa aaaaaaaaaa 196560 agtatacaac caattattaa tgttcatgat ggtagaatca aattaataaa ttaaaaatgt 196620 agatgtgaat tacttttttt ggattgccga ataattgtgg aagatttgta gctgcatgtg 196680 aatccaagtt tcctcaaaag gtaggttggg gtgctcctat ttaggattga atttaagaaa 196740 aatgttaaag aaaagctagc tgctctttac caaagagaga ctggttgttt taagcagtaa 196800 tctaatctat atatttatga tattgaaact attattttat taattcatat aatagatatt 196860 tattaaaaac tccccatatt ataatttttt atttgcaaac aaatatactg aatcaagtaa 196920 gtgaatcaca tatggacctt aaagactaat gaatccaatg tttgacagta ttttatatca 196980 atcaagctct ggtttccaca agcagaagca gatcgtcatc tatgaaacag ataaaagttg 197040 atttggcata ccctctcttt attcattatg atgttcatga gaaaccttct tagaacccta 197100 gggctccaag gaacacagtt tgcaagccac tgatctaatc taactccttc atcctctagg 197160 tatgaaaatc aaggccctcc attacctatt agggatgaag gcaggtcagc ctctgtgact 197220 gtcagttcag ctggaggaag catgagtgta ggcagcacaa caatccctat aaggaccatg 197280 ttcttaagct ggtttttttt ttcctagtag tttttacagt ttcaggtcta acatttaagt 197340 ctttaatcca ggttgagttg atttttgtat acggcatgag ataagtgtcc aatttcattg 197400 ttcggtgtgt agatatccag tttctctaga aacatttatc aaagaaactg tcctttctcc 197460 attgtgtgct tttagcagct ttgtcaaaaa ttaattggct ctaaatgaat gaatttattt 197520 ctgggttctc tattctgttc cattggtcaa tacatgctgt tttaattact atagctttat 197580 agtatatttt gagtcaggta gtgttatgcc tctagctttg ttcttctagc tccagattgt 197640 tttggctatt cagggttttt ttgtggttcc atacaaattt ttggattgtt tttccacttt 197700 tgtaaaaaat gtcattgcaa ttttgatagg cattgcattg aatctgtaga ttgatttgtg 197760 tcatatggat atttttaaca atattaattc ttccagtcta tgtatggtat atctttccat 197820 ttatttgtgt cttcttcagt ttcttttatt gatgtctata gcttttagca tacaattctt 197880 tcacttcctt ggttaaattt attcccaaat attttgtttt atttttatag ctattataaa 197940 tgaaatttct tcttgatttc tttttttgga tagtttgctg ttagtgtata gaaacactac 198000 tgatttctgt atgttgattt tctcttctga aactttactg aatttgttta ttagttctaa 198060 tagttttttg tgtggagtct atacttacat gatctatgtg taagatcatg tcatcagcaa 198120 acacgggcaa tttaacttct tctttttcaa tttgcatgcc tttatttttt ttcttgcata 198180 attgctctgg caggaactct cagtactatg ttgaatagaa gtggtgagag tgggcatcct 198240 tgtcttgtta ttgatcttag gggaagactt ttcaaatttt caccattgag tatgatgtta 198300 gctgtaggct tgtcatatat ggcctttatt gtgttgaggt acactctttc tatatttaat 198360 ttgttgagag tttttgatat gaaaggattt tgaattttgt caaatgcatt ttttcctcta 198420 ttgagatgat tgtatggttt ttgtccttca ttctgttaat gtgtgtacca tagttataga 198480 tttgcatatg ttgaaccatc gttgcatccc tgggcaaatc ccactcgatc atggtgaatg 198540 attctttttc atgtcatgac aatcaatttt gctagtattt tgttgtggat ttttgcatct 198600 atattcatca gggatattgg catgacattt aattttcttg taataccctt gtctggcttt 198660 agtatcacag taatgctggc cttgtaaaat gagtttggaa gtattccctc ctcttcaatt 198720 tttgggaaga gtttgaggat tggtattagt tctttaaata tttggtagag ttcagcaata 198780 aagcccatta ggtcctgggc ttttcttcca tagaggactt tttattgctg attcagtctt 198840 ctttctagct attggtctgg tcagactttc tatttcttca tgattcagac ttgctaggtt 198900 tatgtgtcta agactttatc catttattcc aagttatcca agttgttggt gtgtaattca 198960 tcatagtact cttataattt tttgcatttc tgtgctatca gttgtaatgt ctcctctttt 199020 atttctgatt cagtttattt gtgtcttctc actttttttc ttagtctagt taaaggttaa 199080 tcaattttgt ttatcttttt aaaaacaaat tcgtagtttc actgatcttt tgttttgtgt 199140 ttttagtctc aattttattt atttttcctc cgatctttat tattttcttc cttctactaa 199200 cttggggctt agtttatttt tatttttcta gttatttgtg gtataacatt agattgtttg 199260 agatcttctt ctttgatgaa gacatttatt gctataaact tccctcttga aaatactctt 199320 gctgcatccc acaaattttg gtatgttgtg tgtccatttt catttgtttc aagatatttt 199380 tcaacttttc tttttatttc ttctttgacc cactggttgg ttctgagtat gttgttttat 199440 tttcaagtat ttgtgaattt tccaaaatta ttcttgttga tttatagttt catattattt 199500 atggttggaa aaaatacttg atatggtgtc aatgttctta aatttattaa gacttatttt 199560 gtgtcctaac atatgaacta tactgttttt tttctttttt tttttttgag acagagtctc 199620 actgtgttgc ccaggctgga gtgcactggc tcaatcttgg ttgactgcaa cctccgcctc 199680 ctgggttcaa gctattctca tacctcagcc tcccgagcag ctgggaatac aggagcacac 199740 cgccatgcct ggctaacttt ttgtattttt tagtagagat ggggtttcac catttgggtc 199800 aggctgctct caaactcctg acttcaaatg atctgcccac cttagcctcc caaagtgctg 199860 ggattacagg agtgagccac cgtgccaggc catgatctat actgttttat ctaacattca 199920 gtggataatg ttccatgtgt atttgagaag aatgtgtgtt ctgttgctgt tggatgaaat 199980 attctgtatg tatctgttaa gtccatctgt gctaaagtat agtttaagtt tgaactttca 200040 ttattgattt tctgtccgaa taatctgtcc attgctaaaa gtggggtact gagttcccca 200100 atattattgt attacagtct atcttccctt tcatatcaat taatatttgt ttcattcatt 200160 taggtactcc aatgttgggt gcatatgtat gttcacctgt tatatcctct taatgaattg 200220 accctcttgt cattatttaa tggccttctt tgtcttattt tatagtttgt gacttaaagc 200280 ctattttatt tgatataaat atagctgtct ctgctttctt ttggcttcta ttttcataga 200340 atgccttttt tggtcccttc gccttcattc tctgtgtttt cttaaccatg cattgaatct 200400 cttctagaca tcatataaca gggtcttgtt tttttaaatc catttactca ctgtatctct 200460 ttcttcctat cttgctgtct tcctttgtga ttaggcgatt ttctatagtg gtatcctttg 200520 aattcttact ttttgccttt tgtatatttg ctacaggatt ttgctttgtg attaccataa 200580 ggcttacata aaagatctta tagttatacc aggctatgtt caactgttta taacataact 200640 ttgattaatt ttttaatact caatttattt gattgcttat ttagagataa ttttgattcc 200700 tatcagaaga aaactgaggt atctttatgt accttttcag gaatgaccac gtctcacctt 200760 accttgaatg ttacaagaaa tgctggcagt gactcaaggc caggcaaaaa tttcagaaag 200820 ggtttatctt gtttgtacaa ttttcttttg caaaaataaa tgattcttga tatgatgtaa 200880 ggactttttc cgtagataga acctataaaa tgcagaactt tggggcagta attatatgaa 200940 tgaattgcta ctttaaaatt ctgtaagtcc ccaggaattt ccatatgctt ttttttgttt 201000 gtttcagtgg ttgtgatcag gctaatgggt agtttttaga gctgaaaaga acttaaagat 201060 catctagtgc acctttttgt ttttcagttg gattgttctt gtccaaatca ctaagctaag 201120 ttaactgctc agacaggaaa ccaagtctcc tgacccatgg tttaatgctc ctttcattgt 201180 tatgcgtctg cctggctgac ctgttagtaa cataaagtgt catgagagat agacatatgc 201240 atgagtaaga tattaatatc ccataaacca aaactgtgac ttaggaaatg ttacggtggg 201300 cacaggatat tactcctctt caacaaaaac atcaatcata tgttggctta gttgcacagc 201360 agaagtacca aaataaattt atatagacgg tgtcacagat actttaaaaa gacctactta 201420 agatttaatt acctaatatt atttaatatt taatataatt taaaaggggc atttttatct 201480 ttcagccaag gttttaattg tttttagata attctatttt tgaaagtctg attttgtttt 201540 aaaatgccca ttctggtata taaaaacatc attttgtcaa ataggagtcc cagctaaggg 201600 ccaagcgtgc aattaaactt gactctttac ctactaccta ggaaccttgg gcagatcaca 201660 tactttttct tcactcagtt tttacttctg aaaaatgcca gctgaagtat gtttcaaatc 201720 ttaaatttta tgttttatga tctaagttca gattaacaat ggaatggtta gaatccaaag 201780 ctaaaggtag tatatacaag tgtatattgg gggttgggag caactgccgc agctatcata 201840 tttacatttc aagctcaatt tagaacaact gcgggcaact gtaaaaaccg gtaggaatgg 201900 gcagagttat tgtcttcact agtcattgtg gaaagtgaat ctcttctgaa tggagagtca 201960 caaaaatgag tttgatgctt tcatgatagt gaaatgagaa gatggccata tattgctata 202020 aatcaccagc aacataaaag aaaaaattca aaaatcaagt ttgttgaggc aggactctga 202080 aaagataact aagctttttt tttttttttt ttctgttaga gatgtaataa tcatgactaa 202140 gactggaatc ccaagagctg gtgagacttt ctagtttctg ccttgtggaa agagaaagga 202200 agaggccaaa aaagataatg aattttggaa agttcctgat taaatatcgc ataggctagt 202260 ctggttatgt ctgcttgaaa acttatccag taggtataaa ccaacacact tgaggccagt 202320 ctttttggaa attacagaaa tatatgtcag ccttaagaga catcctatga tgaagagcag 202380 agggagttgt ttataaagaa atgttctcat tggctgggca tgatggctca cgcctgtaat 202440 cccagcactt tgggaggccg agctgggtgg atcacttgag atcagaagtt ccagagcagc 202500 ctggctaaca tggtgaaacc ccgtctctac taaaaatata aaaaaattag ccgggcatgg 202560 tggcgggcgc ctgtagtcgc agctactcgg gatactgagg caggagaatg gcgtgaacct 202620 gggaggcgga gcttgcagtg agccaagatc gtgccactgc actccagact gggcgacaga 202680 gcaagactct gtctcaaaaa aaaattagcc aggcatggcg gggagcgcct gtaatcccag 202740 ctactcagga ggctgaggca gggaaattgc ttgaacccag gaggtggagg ttacagtgag 202800 ttaagatggc accattgcac tccagcctgg gtaacagagc tagactccat ctcaaaaaaa 202860 gaaaagaaat gttctggtca tgcctggaga taatacatgg tttagtttat gcttgattca 202920 gcaaataaaa attggtgagg aacatacaga attatattta ggtgattata ttttttatat 202980 tttatatata aaatttatat tttttatatt ttaggtgatt atatttttaa acgcttgctt 203040 tacaagacta atcattatta cttttttaag ttttgtgata tattttattt aactaatata 203100 ccccaaatag tatttcaata cagaatcaac atttaaaaat tattgataca ttatgtatgt 203160 ttttttcctt cactaagact tccaaatcct ccaagtgttt cacacttaca tcttattttg 203220 gaccagccag attttagtgc tcatttgacc atgtgatctg tgcttaagga ggctgctgga 203280 gctgaggctg ggctgcagta ccaacataga agtctttatc tgtcaaacca ggagtttgag 203340 atccctgagg gatatgggaa ccataaagga tcttaagcag agaagtgact ttcttaattt 203400 tgaacctatc ctggtgttct catagattag aggagagaga tttaggagtg agggatcaag 203460 caagaaggtg gctccacatt gttttccata gtagttgtac tagtttacat tcccaccagc 203520 agtatagaaa tgttcgcttt tcactacatc cacaccaacg tctattattt tttgattttt 203580 tgaaaatggc cattcttgtg ggagtaaggt ggtattgcat tgtggttttg agttgcattt 203640 ccctgatctt tggtgatgtt gagtattttt tcatatgttt gttggccact ttgtatcttc 203700 ttttgagaac tgtctattca tgtccttagc ccactttttg atgggattgt ttgttttttt 203760 tcttgctaat ttgtttgagt tccttgtaga ttctggatct taatcctttg ttagatgtat 203820 agattatgtc tccttctctg tgggttgttt gtttactctg ctgctgctcc ttttgtgcaa 203880 aagctcttta gtttaactaa gtcccactta tttatctttg tttttgttgc atttgctttt 203940 gggtttttgg tcataaaatc cttgcctaag cccatgtcta gaagggtttt tctgacgtta 204000 acttctagaa ttttatggtt ccaggtctta gatttaagtc cttgatccat cttgagttga 204060 tttttgtgta aagtgagaga tgaagatcca gttgcattct cctacatgtg gtttggcaat 204120 tatcccagta ccatttgttg aatagggtgt cctttcccca ctttatgttt ttgttggctt 204180 tggcaaagag cagttggctg taagtatttg ggtttatttc tcggttctct actctgttcc 204240 tttggtctac atgcctattt ttataccagt accatgctgt ttcggtgact atggccttat 204300 agtatagttt gaaatcaggt aatgtgatgc ctccagattt gttctttttg cttagtctta 204360 ctttggctat gtgggctctt ttttggttcc atattaattt taggattttt tttctagttc 204420 tgtgaagaat gatggtggta ttttgatggg aattgcattg aagttgtaga ttgcttttgg 204480 cagtatgatc attttcacaa tattgattct actcatccat gagcatgaga tgtgtttcca 204540 tttgtttgtg tcatctatga tttatttctt tgagaggtgt tttgtagttt tctttgtaga 204600 ggtccttcac cttcttggtt agtttttgtt ttttttggtt tttttttttt tttgcaacta 204660 ttgtgaaaag gagtgagttc ttgatttgat tctcaccttg gttgctgctg ttggtgtata 204720 gcagagctac tgatttgtgt acattaattt tgtatcctga aactctgctg aattcattaa 204780 tcagttctag gagctttttg ggggagtctt tagggttttc tagttataaa atcatatcat 204840 cagcaaacag cgacagtttg aattcctctt tactaatttg gatgtccttt atttctttct 204900 cttgtctgct ccggctagga cttctggtac tgtgttgaat agtgagagtg ggcatctttg 204960 ttttgttcca gttctcagag gaaatgcttt caacttttcc ccattcagta ttatgttggc 205020 tgtgggttta tcatagatgc cttttattac agtgaggtac cttgtatacc gattttgctg 205080 aaggttttaa tcataaaggg atgctggatt ttgtcaaatg ctttttctgt atctattgcg 205140 attattgcga tggtcatgcg atttttgttt ttaattttgt tcaggtggtg tgtcacattt 205200 attgacttgc atatgttaaa ccatccctgc atccctggta tgaaacccac ttgatcattg 205260 tggattatct ttttgatatg ctgtttgatt tggttagcta gtatttcgtt aaggatattt 205320 ttttgagatg gagttttgct cttgttgccc aggctggagt gtagtggcac tgcaacttcc 205380 actttctggt ttccagcgat tctcctgcct cagctccctg agtcgctagg attacaggca 205440 cctgccacca cacccagcta atttttgtat ttttagtaga gatagggttt cgctatgttg 205500 gccaggcggg tcttgaactc ctgacctcgt gatccacctg ccttggcctc tcaaaggact 205560 ctcaaagtgt tgggattaca ggcgtgagcc acagcgcccg gccagatttt tgcatctatg 205620 ttcattagga atattggcct gtaggtttct ttttttgttt tgttctttct tggttttggt 205680 acaagggtga tactggcttc atcgaatgat ttagggagga ttccctcttt cttcatcttg 205740 tggaatagtg tcaataggat tggtaccaat tcttctttga gtgtctggta gaattcagct 205800 gtgaattcat ctggtcctgg actttttgtg ttgttggtaa tttttaaatt accatttcaa 205860 tcttgctgct tgttattggc ctgttcagga tttctaattc ttcctgactt aagctaggag 205920 gtttgtatct ttccaggaat ttacctatct cttctaggtt ttctagttta tgtgtgtaaa 205980 ggtgttcata gtagccttga atgatctttt gtatttctgt ggggttggtt gtaatatctc 206040 ctgtttgttt ctaattgagc ttatttggac cttctctctt cttttcttgg ttaatcttgc 206100 taatggtcta tcaatttcat ttatcttttc aaataaccag cttctttttg tttcatttat 206160 cttttgtatt tttttttcaa tttcctttag ctctgctctg atcttggtat tttctttctt 206220 ctgctggctt tgggtttcgt ttgtttttat ttctgtagtt ccttgatttg tgaccttaga 206280 ttgtctattt gtgctctttc agagtttttg agtaggcatt taaggctgtg aactttcctc 206340 ttcgcattgc ttttgctgta tcccagaggt ttggatggtt gtgtcactat tattgttcaa 206400 ttcgaagaat tttaaaattt tcatcttgat ttcattgttg acccaatgat cattcaggag 206460 caggttattt cacttccatg tatttgcatg ttttggaagg ttccttttgg agtcgatttc 206520 cagttttatt ccactgtgga ctgagagagt agttgacata gttttaattt tcttagtttt 206580 tttgacactt gtttgtggca tatcatatgg tctatcctag agaaagttgc atacgctgat 206640 gaatagaatg tatattctgt ggttgttggg tagaatgtta tgtaaagatc tgttaagtcc 206700 atttgttcca gggtacaatt taaatccatt gtttctttgt tgactttctg tcttgatgac 206760 ctgtctagta ttgtcagtgg agtattgaag tcccccacta ttattgtatt gctgtctgtc 206820 tcattactta ggtgtagtag taattgttct atacatttgg gagttccagt gttaggtgca 206880 tatatattta ggattatggt attttccttt tggacaaggc cttttatcat tatataatgc 206940 tcttctttgt cttttttaac tgctgttgtt ttaaagtttg ttttgtctga tataagaata 207000 gctactccta cttgcttttg gtgtccattt gcatggaatg tctttttcca cacccttacc 207060 ttaagtttat gtgagtcctt atgtgttagg tgagtttctt gaaggcagca gatacttggt 207120 tggtgattgc ttatccattc tgcaattctg tatcttttaa gtggagcatt taggctattt 207180 aaattcaatg ttagtattga gatgtgaggt actattctgt tcatcatgcc atttgttgcc 207240 tgtatacctt ggattttttt tagtagtatt tttgttttat acctccaatg agatttacac 207300 attaaggagg ttctgttttg atgtgtttcc agcatttgtt tcaagatttg gagctccttt 207360 tagcagttcg tgtagtcatg tagtgctggc ttggtagtgg cgaattctct tagcgttgtt 207420 tttatctgaa aaagactgta tctgtccttc atttaagaag cttagttttg ctggatacaa 207480 aattcttggc tgctaattgt tttctttaaa gaagctgaag atagggcccc aatcccttct 207540 agtttatagg gtttctgctg agaaatctgt taacttgatg ggttttcctt tataggttac 207600 ctggtgcttt tgcctcacag ctcttaagat tatttttctt atcttaactt tagataacct 207660 tatgacaatg tgcctaggca atgatctttt tgtgatgaat ttttcaggtg ttatttgagc 207720 ttcttgtatt tggatgtcta ggtctctaat aaggctaagg aagttttcct caattatccc 207780 cccagatatg ttttccaaac ttttagattt ctcttctttc tcaggaacac caattattct 207840 taggtttggt tgtttaattc tgtcccaaac ttcttggagg ttttgttcat tttttttttt 207900 ttttcttttc tttttttttt ttaattgatc attcttgggt gtttctcgca gagggggatt 207960 tggcaggatc acaggacaat agtggaggga aggtcagcag ataaacaagt gcacaaaggt 208020 ctctggtttt cctaggcaga ggaccctgcg gccttctgca gtttttgtgt ccctgggtac 208080 ttgagattag ggagtggtga tgactcttaa cgagcatgct gccttcaagc atctgtttaa 208140 caaagcacat cttgcaccgc ccttaatcca ttcaaccctg agtggataca ccacatgttt 208200 cagagagcac agggttgggg gtaaggtcac agatcaacag gatcccaagg cagaagaatt 208260 tttcttagta cagaacaaaa tgaaaagtct cccacgtcta cctctttcta cacagacacg 208320 gcaaccatcc gatttctcaa tcttttcccc acctttcccc cctttctatt ccacaaaact 208380 gccattgtca tcatggcccg ttctcaatga gctgttgggc acacctccca gacggggtgg 208440 tggccgggca gagcggctcc tcacttccca gtaggggcgg ccgggcagag gcgcccctca 208500 cctcccggac ggggcggctg gccgggcggg gggctgaacc cccacctccc tcccggacgg 208560 ggcggctggc cgggtggggg gctgaccccc ccacctccct cccggacggg gcggctggcc 208620 gggcgggggg ctgacccccc cgcctccctc ccggacgggg cggctggccg ggcagagggg 208680 ctcctcactt cccagtaggg gcagctgggc agaggcgccc ctcacctccc ggactgggca 208740 gctggccagg cggggggctg aacccccacc tccctcccgg acggggcggc tggccgggcg 208800 gggggctgac ccccccacct ccctcccgga cggggcggct ggccaggcgg ggggctgacc 208860 cccccacctc cttcccggac ggggcggctg gccgggcaga ggggctcctc acttcccagt 208920 aggggcggct gggcagaggc gcccctcacc tcccggactg ggcagctggc caggcggggg 208980 gctgaccccc ccacctccct cccggacggg gcggctggcc gggcgggggg ctgacccccc 209040 cacctccctc ccggacgggg cggctggccg ggcggggagc tgaccccccc acctccctcc 209100 cggacggggt ggctgccggg cggagacgct cctcacttcc cagacggggt ggctgccggg 209160 ctgaggggct cctcacttct cagacagggc ggttgccagg cagagggtct cctcacttct 209220 cagacggggc ggcccggcag agacgctcct cacatcccag acggggcggc agggcagagg 209280 cgctccccac atctcagacg atgggcggca gggcagagac gctcctcact tcctagatgg 209340 gatggcggcc gggaagaggc gctcctcact tcctagatgg gatggcggct gggcagagac 209400 actcctcact ttccagactg ggcagccagg cagaggggct cctcacatcc cagacgatgg 209460 cggccaggca gagacgctcc tcacttccca gacggggtgg ccccgggcag aggctgcaat 209520 ctcggcactt tgggaggcca aggcaggctg ctgggaggtg gaggttgtag cgagctgaga 209580 tcacgccact gcactccagc ctgggcacca ttgagcactg agtgcggttt tgttcatttt 209640 ttaaattctt ttttctttgt ctttgttgga ttgagttaat ttgaaaacct tgtctttgag 209700 ctctgaagtt ctttcttatg cttgttttat tctattgctg agactttcaa gaacattttg 209760 catttctcta agtgtgtcct tcatttcctg aagttgtgat tgttttttat ttatactaac 209820 tatttcactg aagatttctc ccctcatttc ttgtatcatt tttttgactt ccttaaattg 209880 gacttcacct ttctctggtg cctccttaat tagcttaaca atcgaccttc tgaattcttt 209940 ttcaggtgac tcagggattt cttcttggct tggatccatt gctggtgagc tagtgtgatt 210000 ttttgagggg tattaaagaa ccttgttttg tcgtattact gggattgttt ttctggttcc 210060 ttctcatttg gtaggctatg tctgagggaa gtactagggc tcaaggctgc tgttcagatt 210120 cttttgtccc acaggttgtt ttcttgatgt agtactctcc cccttttctt agagatgtgg 210180 cttcctggga accgacctgt agtgactgtt atttctcttc tggatctagc cattcagcag 210240 ggctaccagg ctccaggcta gtactggggg ctgtctgctc agagtcctgt gctatgggct 210300 gttttcaggt ctcacagcgt tggattccag cacctgctct gatagaggtg gcaggggagt 210360 gaaatggact ctgcaggggt ccttagcttt tgttgtttaa tgcactattt ttgtgctggt 210420 tggcctcctg ccaggaggtg gcactttcaa gacagcgtca gctgtggtag tatagggagg 210480 atcaggcagt ggccagggcc ttagaactcc caagagtata tgacctttgc cttcagctac 210540 caggatggat agggaatgac catcaggtgg ggcaaggcta ggactgtctg agctcagact 210600 ctcctcgggt gagtcttgct gaggctgtgc tgtggggcag gggggtgagg ttcccaggtc 210660 aatggagtta tgttcccaga ggattatggc tgcctctgct gcgtcatgca ggctgtcagg 210720 aatgtggggg aaagccggca gttacaggcc tcacccagct cccttgcaac ccccaaaacc 210780 ggtctcactc ctgtgcccta ccaacagcat caagtttgtt tgcaggcagc ggatgagcaa 210840 ggctaagaac ttgccgcagg ctaccagcct cccagcaaag aatgtaagta gggctttcat 210900 gcctcccttc ctgttgaatc tgtacaccaa attcactccc tcccccaagt tctggccagg 210960 tgacttcatg tttggttgga attgttacaa agttcagctg gaggtttcct tctcgctgtg 211020 gtcttttccc agttcctctg gccaccctcc ccaaggaccc ctgtgagaca aggtagaaat 211080 ggcttattag gggacccaga gagcccacag ggcttttccc cttgctttct ctacccttta 211140 tttcactcag ctgtctaatt aaatcagctc caggtaagtt catatccttc tcccatgatc 211200 tggagctgca gattccccag tgagggtgtg tgttcggggg tgggctatcc ccctttccta 211260 ctttcacagc ttgggcactc acagtatttg gggtgtctcc tgggtcctgt aggagcaaac 211320 tgcttccttc acagggtctg tggattctct tggctttcct ggtatattcc tgtagtagtt 211380 ctggagcaga agtttatggt gtgagtttcc acacactgct ctgttcatcc aagtgagagc 211440 tgcaatctag tcctgcctcc tttccaccat tttttggcct tgacgtatta catttatttt 211500 atgtttgaag ttttggcagt tttattttga aaattttaca taacaaatgc caagccaaat 211560 ccaaacttct tggcctaaat catttacaga taacctttac tgagcattta ctacatgaag 211620 gtgttgttga cacaggggat ttaagatgtg atcactgacc acaacatcca ggcaacctaa 211680 aagtgaaaag aggtcattca caaaaaatag gaccaaactt cctccattcc tcaagggacc 211740 taggactgga gttggcctaa aaattcctgc tgtatcacct cacccaccag ttttgatctt 211800 gctctcaggg atcaaggaag ctcaaggttt ctggcccttt tggctcatgt tcttggaggt 211860 atattctatt gtcaagttaa agtcgtaccc atcctagatc tgtttctctc tctttgtggt 211920 tccagtctca tagaaaacat aactatgtga aaacaccaac taccccataa agctattctg 211980 agactcaaag acatgaactc tattttgata atcacaaatt gatgtataga tgtcagatat 212040 cattcatgta ttatgtagca ttgtggttta agtcttagct gttggaatca gactacttgc 212100 attcaaattt tagctctgtt gataggtgtg taaccttgaa caagatacgt aacctcttca 212160 gacctttgtc tctttgtttg tcaaataacg acaataataa tactaactta gtaagtatgt 212220 ataaggaggc atgtaaagct tctattgtat ttggcttatg gtgagccctt catataaatt 212280 ggttacaatg ggtaatgaaa agtacgttca atttttccca caaggattta atctaatctc 212340 taaataaaat gccagtttta gtatactgtc atcattataa ggaaactata attcttaagt 212400 aattaattac tttggttccc tttggataat tagtgataca taaaatgcag taccttgccc 212460 tgaggaacct acaagttagc ctccctctaa tcctggcatt caaagtcctc caccttccga 212520 attacacctg ttttttcagg cattgtctcc cactttccta gcaagccttt ggctccagga 212580 aactgttctg ttcattgacg acagaatgta ttttgtcccg tatgcctccc ttcaatctga 212640 agttcatttt tagtaatttt ttttattagt agtgactttc cccatttact aatgcctttc 212700 tctttagctc atttagaatt ccctggaagt catcatgttt tccttctgaa ttgctatcat 212760 attctgtctc tgtgtctaat cagaaagtta ggtgagctgc tgtctcagct cctgtgttaa 212820 tccaggtact gagctctttg taccctgcca gcttgagggc aacttggatg cgctggtgtg 212880 tagtgatttg caactgtgag agagccgttt ccatcaacaa gtgacagctt ttggttctaa 212940 acactgcttg acctcattct ggtttgaaca tatactttgg cctctgccct ctacctcacc 213000 tccagttctg atcttgggca tgccacagaa ccccatctac actaggcttt cattttggac 213060 ttctaagtcc tttacttgac cacttatttt ctttaattgc tagacttaat catccatgca 213120 tatgacagcc actcagctct gaccccaata cttcattgag gctcatgcca gtctgacctc 213180 tcacagggaa gagcacccct gccggtgagc ccctggccct tggattatgc tgtcccacca 213240 gtgcccagct ggctgcttgg cactgcatgt gatgtatctt tgtttattga tcgcttaatt 213300 gaatgggata taggattata ttccatgttc cagatcaagt tgagccaagc tgacaactta 213360 gtattaaaaa aatatattta tctcctatct gtccaattaa aattttaatt tctagaggta 213420 gagacagtca cattgctatt taattcctag cacagcagta tttttgtcaa tatttgttat 213480 tagtggtgag tttaaattat aaaggaaaaa agagaagtgg tgatttatgt cagcgcttgg 213540 ctaaactatt cccttgatat aagtctatta ttcaggtcac ataagcatga ctgaagtaat 213600 atcacaacca taatatcata attatctctc ttgctgtctc tgtcactttc tcacttttgt 213660 ttgtgcatag tgcatagacc tgtagaaaat ttattagtaa tctgaagcat aaaaccaaat 213720 attacaacta tcataacaaa taaataaaac tgtgcactcc tttagggagt agtaaagcca 213780 tttctaaaat taagtcaaag taagattccc ttattattga gatattttag tggtatacac 213840 tatcataagt aagatgaata attttgttag cagctgacac tgctatatag atatttatct 213900 tgggaagttc tcagtgtaac atctttactg tgtttttctc tttagattat acttttatgt 213960 ttattatttt gtttcgtggg ggattcaaaa atatgcattt tatgccatac ttggggattc 214020 cctataaatt attagttgta atatgacagt tccatcatga attttccagg tattctttta 214080 tgcaagcaga taatagctca ttttggtttt taacacattc atgcatattc tttctctctc 214140 aataaatatg gttttaattt attaaatgaa agatttaaaa atgtgctaag cattttaata 214200 ataatcgatt ttggattaac ttgttatgtt tactctaggg ctgtagttca ccatttattc 214260 agttaagtcc ttccccaaat tcaatattga acatgtggaa ttgattcgtt tcacgtggat 214320 gtatcattta ctcccaagat gttggttttt ggcatttagt actggtaatg ggccaggaaa 214380 gtgctcatct atatttgttg ttattcactg attgcatctt gcccttgcac ccactgagac 214440 gatgggaaag tagcaacaat actaggtgat ttctttgatt taaacccaat taaaagaatt 214500 agagagttgt ctgatacaag gccaaagaac taagaacaga aacaaaagca aaacaacaaa 214560 cagcagcaca aactccagtg agataaattt ttaaaacatt gggaatattt aaaaaataaa 214620 aacactccaa tgaaccaccc aggttttatt aaagagtaga gaactcaaac agcagaaggc 214680 agagctggtg gaggaaactc agcaactgct cagaaatgaa acaacctagg aaggaggtgc 214740 gagtgacctg aaactccttt taaaaacaga aaggacaaaa agaggtatgg gctgacaaaa 214800 ggaaagtggt agattactga tgtattgcat tatgcttaga atgtctcaga atgcgagagg 214860 cagtaaacac accagaagag gatacaatat ccggaccatg tgcaactgca aataaatgtt 214920 tgggttaaaa cttggttgat tctaaattac atgaagagct gatgataatt gaggcagaac 214980 tgatagacct aacaatagaa aaaaatcgat ttaaattcag agaagaggtc atttaagaaa 215040 gtataatgaa gccacttaat aaaaggaaat attcctctaa ctaaagtttg agatttaggg 215100 cataatcctc aaagacaggc taatataatc tattttttga ttaaaaaaag gaacttttgg 215160 tttaaagtaa gatgttcagc tgctcttaga gtttatttct ccatatttgg gcatataaga 215220 atttaaggaa aaatatagaa atataagaaa gatttcatga gaatcacaag catagtttat 215280 aggcaagata gccttttctg tttgaaagcg aaaaatacta tttcaacatg taaaaaccta 215340 agtcagtttt cactggcatg tcccacaatc atgcctgaaa taatggttga agacagatgt 215400 gagacatttc aagggcaata gattaataca tgaaacccac ttatgcctag cgttccatta 215460 ttggaacgct aagcatgtgg gagttattta tatcctattg ctcaaggtca tctccaaggt 215520 ctgagttttc actcatgcaa aaattcaaaa aattgcaacc tcggcgtaaa tgggttaaca 215580 aaaagttaat gctggacagt aaaataaact actaaattag acacaccata ttttttaaat 215640 tataagagat taagaactat gagatattta aaaagccacc cacagaagta gtaggacagg 215700 tagagaagga taaattctaa caatcaactg tatctccacc ccaccttgta aatgacaaat 215760 tagtttactt agtcaattca ggaaattaaa cgtatacatt ttgtgttaaa acagaagact 215820 ttttttaaaa aagtgtgtta gttaaggtta attttgacct agttaagaaa aagcagttta 215880 gagtcttgaa atggaaatga gaaatacata attaccctta aaaataagtt gatagtgaat 215940 tttatctagg attcttaaga catttttaat atttaatgaa aatgaactac acaattatta 216000 aaaaatagtt gcctgggttt agaaaaatga tcccttaata agacatatac aacagcctga 216060 atttttattt ccaaatacta tagcaacaaa ataccggcaa gaaaaatgca cagaaacatt 216120 ggatagtctc ttcttactaa tcttttacag atatttatat attctgaatt ctaactttta 216180 atttatttta tgtattataa atgtcatcta gtatgcagct tgactttgct ttatggtatc 216240 atctgtttca cagaaaattt taagttgtgg aatttatcgt attttttctt tatagtttgt 216300 gctttaagac ctgtctaata aatctttcct tccctggacg ctataaagtt atttgtctat 216360 attctgttaa aaggaataaa actttgcttt ttttcacatt ttgttactta tttcacctga 216420 aagagaattt tgtttattat gtgaggtagg aatataactt aatttttttc cattgaataa 216480 ccaaattgtc ccagagcaat taagcaatac attctttccc tgttgatctg tgaagctacc 216540 tccattaggc atgaagttgt cctgttgaag agaatctgat tctgagctct cttcactatt 216600 tctttatttg tctatgtcta cactaaaagc aatttaattt ctgtgtcttt ataattactt 216660 tgactttata atccttgaaa gggactttgt tcttcttcaa aattgttttg gctatttatg 216720 gctacttttg ctttcaaatg agtttttaaa tcaaacttta atgagattgc attaaactta 216780 taaattaatc tgaggaggat tgacatcttc atgatattta gtcttcctac ccattaacat 216840 tatataactc tccatttatt ttaggtcttt ttgaatgact tctaataaag tttttcaatt 216900 ttctccaaaa tatcttacat attaaaattt actcatagct gtctcatctt actgatattt 216960 taaagacata tctttttaaa aattatatta ttaaattgtt tcaggtatgt cttttttttt 217020 gaagttttac aaatttggga ttatactgcc tcttcattca acattttccc atgctgttgg 217080 ggatccttca agtcaaaatt attagaggag ctgcattaat attccagcat ggacatacta 217140 taatttattt aattatttcc cgaattgtat gtttttgttt ctaacttcac agttttcaac 217200 atgactggga acagcttttc ttgctaaatc cttgcacgcc acagtaatta tctcactggg 217260 ccaaaagata ggtacttttt catgactttc gccatatatt gtcaaaatgg aaccaatggt 217320 gatttgttca gaaatcatgg tacatcatat aaaaagatta ctctgcaagc atcacaaact 217380 gtgatatata gaaatgtgtt tattgacatg aaatagatca tgaagaaagt gattacaaat 217440 ggtatttaag cattttaagt tatataggct tatactgagc aataacaaag agggtgaata 217500 aatgaatgaa tatgtgattc tggaagggta tgtaacaaaa ggttaacaat ggttagccct 217560 gggtaagggg attatgtatg acttttattt ccttcttttt ttcttccttt ccccttatgt 217620 ttttaacaat gtacatgaat cgtttatgaa taaaataaaa aactttgata ttcttatata 217680 ggtttagtag gataacattt ctccttcatt tctttcattt ttagaaatct ttcttcacgg 217740 aaattctttt ttttaaatgt ttatttctgt ctttgaggag tgagattgac tggctatctt 217800 ttaatacctg tgtgtattat cattattgta tcttgctgat aaatttcaca acagttaatt 217860 attttattcc ccatttcata cttagctcta ttttaggcaa gttcacaaat atcattgaat 217920 gagttcattc aatgtcatca tgatgatatt gaaatgtcaa tagcagatga cttgtttctg 217980 gggtgttaat atgcctgttg gttacatttg tgttttttgg tgatggaagg cagccactga 218040 ggcaaacagc aagaatacag ctaagcctct aactgcatac tcttctcact cgttgcttaa 218100 aactgaagcg tggataattg gtgtgcattc cctaaaaagt tatgtcatga tgcagtagag 218160 aaataagtta actttcctat ccctgtatca aagtttcttt tgaaggtaac tgagacagcg 218220 ccaaataagg agcagagttt ctgtgaatca tgaaatcttt ctaaacaatt gagaaaaaaa 218280 aaactgttct gaaacaaaaa cttgtgccct atccttttat ttgaatgtgt tttcttaagg 218340 ccacaactgg cagagatttg atgattttat gtttaaagca attttttttt tttttcatag 218400 caaggagtcc cactgccatc aggttttgtt tttggagaga ttctgtaact gacatagggt 218460 aacttactct gatggcttgc tccacattca ctacaagtac atactgttct gaaaaatctc 218520 aaagttgaaa tatttttatt tgggcaactt ctgcaatcaa ggtaattcac tctatctttg 218580 gagaataaaa tggaaaaggg caacccaatc tctgtgacct taaacttcca ctgaaactta 218640 gagacggtta gcttagctgg tgagagcgtg ctgctaataa caccaaggtc gtggtttcta 218700 tcccattaca gggcagtcaa gctcaaggga aaaaccctgt tctttggcac agcttccatg 218760 gcctgctagc cgtttacagc gaggcaaaag agtagagatg ttttagtgaa ctaggccatg 218820 acttggggag tctccacctt gaatctggtt gtgggaccaa ggaagagaat ctgctgaggc 218880 tgggtagaga gactctagag caccttaggc cacaggacag cagaggatga gaataacaga 218940 actggcttca gaaagtaggt gtcagtccaa ggcactgtat tcaatacatg tagcaaagaa 219000 tgagcttctg acaccaggaa agtcttcaga tggcagtgac tgcataaacc ggtgtcagga 219060 tgtctgacta taaaggatgg gacaccttcc atcaggtgag agctctggag gtggagtctg 219120 ttcctggaag aagcatgggt aaatgtcatc aaaggttccc tcagccacca ctgggttcag 219180 ggctgaggtg cacctaggaa ggcttgggca gaagcatgac ccctggaact tggccaactg 219240 agccatcaga gagtggtgca ggtgaggagt ggtagatgtg tagtgaacca ctcagctgtc 219300 tgcccaggcc ttgggtgtgg aagtagagtc ttctgtgtct ttgggcagac tgaattataa 219360 gcttcaccag atcgccaagc taggaatgtt gacatacctg gcttggggtc agggagggac 219420 tgaactgtag gtggggggcc ccaacaaatc taatcataag aatctatgag cgtggagaca 219480 gaaggaccaa agaagggatg ctgtaaccaa ttatcattat tgaaaaacta ggcagagatt 219540 acattcaatt ggcagtacca ccctttttat ctctgacata gttccagaag gatatactat 219600 gtatctagtg tgacactgtc tgatagaatt gtctgaaatg atggaagtgt tctgtggcta 219660 cccattttga tagccactag ccacaggtgg ctattgagca cttgatatgt tgttggtgtg 219720 actgaggaac taaattttta attcaattta aattaaattt aatttaaatt taagtagcaa 219780 catgtggctg gtggttactg gattgaaccg aacagatcta gatactagag taagtggtag 219840 cagcaaatcc tatattggaa caatgtaaat taacaattat aaatatatga gcaggacaaa 219900 gcccaaatgg gcctgtactc ttagttttgc tatatattca accataacta gcactcattt 219960 tttaaactta taaaatgcaa actcatttgg ttgtgatgat gaatgctcag gtaattgttg 220020 agtttcaaca cagtgacagc caggaactca ttttggagac ttggattgtg ccacagtttg 220080 tccctctata aaatgatgat gaaaatttta tcagtatctg tctcaagctg tagttaatgg 220140 gccaatttct aaatattcct gtcaaattgt atagccattg ttttcaaagt agttttgaaa 220200 gtaggccatt ggtaaagcaa tctattaaag tgcaggaaga aagtaataga atctcttact 220260 ttttaaagtc tcattatgaa aattatattt cagtttgtat gccttcgatg tacataatat 220320 attaatacac aaatatatta atgcagcggt ccccaaactt tttctcacca gggactggtt 220380 tcctggacga cagtatttcc atggattgca gcggggatgg tttcaggatg aaactgaccc 220440 acctcagatc atcaggcatt attaggttct cataaggagc acacagcctt gagcaggtgc 220500 agttcacata tagggtttgc gcacctatga gaatctaatg ctgccgctga tctgacagga 220560 aatggggctc aggcagtaat gctcgctcac tgctcacctc ctgctgtgtg gcccagttcc 220620 taacaggcca tgaactggta ccagtctgtg gcctgggggc tggggagtcc tgcattaatg 220680 taattaaata tgtacatttc ttgagagtgt ttgttcaaat attttttcct aatagagacg 220740 tataacttag aaagtatgga accctctggt cagtagcata ttttatcaaa aaggctatcc 220800 gtcgtgctaa ccaatgtgat taaatgttca ttttagtctc agatattttg ataacataat 220860 aatagggaag ttatggttat tgcatggctt ttctttactg tattttcaat aactatatta 220920 atgggttcag ttgttactag ttttataatt ctgttttatt ctcaatgagt cttcctgttt 220980 ctccccacgt ctttcctatg gttcatttcc ctgcatcttt acagctccct ggaacattct 221040 ctcaaatcaa tcagaggctt caaaactggg cagtctcatt ttgtaacctg ctctgactcg 221100 cctctgggag gcctccctcc ccactcacag ctgccttcct gcatgatgta aaatgaatac 221160 agtgccagaa agactgatcc ttggaacctc ttccttactt agtttcttta tagttctgat 221220 tttagaaatg accattttac ttccagtgcc cttccccaca ccagttagct gagactctat 221280 gcaggaagtt cccagtgatc agaactgttc ccatagctcc caggtgattc tgacatgcac 221340 ccggcattga gcaccatgga catggctgct gtttgttatc ctcgagctct gcaaagcagt 221400 gtcggatatt gcttgattgt tgcacattaa tctactgcac ggtccggtag gtagccacta 221460 gccacatgtg gccatttaga tgtaaatgaa tttaaattaa atagtattat aagttcaaca 221520 cctcagttgc actctctgta ttcaagtgct cagtagctac aagtggttgg tggctaccat 221580 tttgggcagt gctactatac aacatttcta tcaccacaga gagtgctgat gaataatagt 221640 actaacaact ggaaacattg aaatggagag gtgaaggaga gaaggcagaa tataagagaa 221700 acttcaaagc attcagcgtg tctgataggc gctgtatctt acattatgtt tggagcatag 221760 tttttgaatt tcttaatttt caaattcggt tgaaacagat tttggtcaat tgaagtgaag 221820 gactatgcct gctttaattt gcgtagctta cctttgtttc acgtgtctcc cttattacag 221880 tgtttgtagc agcatctaac tcaatcccta acttcttttt ggtgcaggga ccatttaaaa 221940 acaatttgat catagaggtt atctcctttg caatccatat tgttttatgg aacaggtgaa 222000 cagctggtga caatagcctc aaggtttcta atcccaccaa aggaaaatat ggtgtcagta 222060 attaccttgt actatgatat ttgtgaaatc caagagaggg ctagatctca ggctctaata 222120 atacatccgt ataaacatct cagtagggca ccacggaaga gtcttaggat atcaggaaca 222180 ataagagcgg gagaatatcg accttaatat tctttacact tattaaaaag tgaaaagaca 222240 gccataaagc agaatgagtt cctgtccttt gcagggacat ggatgaagcc agaagccatc 222300 attctcagca aactaacaca ggaacagaaa accaaacacc tcatgttcgc actcataagt 222360 gggagttgaa caatgagaac acatggacac agggagtgga gcatcacaca acggggcctg 222420 tcgggagttg ggggactagg ggagggagag cattaggaca aatacctaat gcatgtgggg 222480 cttaaaacct agatgacggg ttgataggtg tagcaaacca ccatggcaca tgtataccta 222540 tgtaacaaac ctgcacgttc tgcacatata tcccagaact aaaagtaaaa taaatgaaaa 222600 agaaataaaa aataataaaa taaaataaaa taaatgaaaa gtagccattt taccagttga 222660 gtatttactg acttttggtg aaaatcactt tctaagatta ctagaaacct tatgaccctc 222720 ggcctctact cccaccacgt gcggattttc acctccacct actttgtcac gtcacatgcc 222780 cttctgctct ttaggacact tgtattgggt tcctccccca cacgtaaaca gaacacacag 222840 gtctgtgaat ggacctcatt atgctcattt gtctttgcca agaactattg aaaatgatca 222900 caaatgacta tgtaattata attaagattt tgtacatgca tacactttat ttttaacaag 222960 tttgtcctgt taaatgtcac cccattttga atagtaacat tcactggtgc aaggaagaat 223020 tattaaaatg acaatttaac tgatatcctt gacaggtaag ccagttattg tatttcataa 223080 ttgtgattat tacaatacct atgaagatta attaggacaa tttattctat aggacttggt 223140 tatcaaaatg atcttttttc ccattttagt ccatacatct tcagttttaa tttccttctt 223200 ccaaagaact ctgagtcttg cccagtgtga tacttcagat tttgtaaaaa tataatgaag 223260 aagaataaca tgtatcagat ctttttttta atgtactggg ctaaaaatta taagcaccat 223320 caaattacta gaaaattctt ttaacactct gcttcttagt taaaaaatga ttcctttttg 223380 tgataatctt ataattttca aagtatcatt ttagaaattt taaaaaatta ttcttgtttt 223440 cattcagtcc atttcatcag aacttagatt ttttcttccc tctacagtat gtggtcttga 223500 tgtgctttct ccttgcaaaa taaaatcttt agtttcagga tctctgtgtt ctattccttc 223560 aatttaaaat cataggaaaa ataactatca tttccttatg tctgtctcca attcccccat 223620 cattttctgt gagccaattt tcttcttttt cttctgtcta ctgtaaggaa ctttttactc 223680 tgctctattc tctgcaattc agggctcaca atttctttga cttctcagat tatcctttgt 223740 acttgtgtct actttttcat taaaaaaaaa aaggcttcgg tcttattttg actttatcat 223800 ctttatattg ccatatttaa aacccatctg cttattgatt gaaccaaact tttcatctta 223860 cttcatcata ctgaatgtat aacttctgaa tgacttaaaa atcatcacat aatgtgagag 223920 aattttctat catattcagg tgactgcatt gtaagcaatg aagttgaaga aaaatagctt 223980 ataatggata taataccaag aaataataag aatgagaatc tgcgtatatc atatactggg 224040 ttaacaagct cacaaggcaa atcaccattt tattagatat ttaacaaatc atactagtac 224100 tggaggaagt atagcagaaa aaaggagtat ggacattggg attagctgcc ttgctaatct 224160 tttgtcagtc cctagtgaca tgcttttggg ttgagtcatt gttacctccc tgagctgttt 224220 gtttataaaa tgggggtaaa tatctcagat gtttcagtgt tgtgacatat aaagcgtcct 224280 ccatagtaca taataccgta agcactccat aaggtaattc ttgtcctttt aaaaagtata 224340 cacttttgag ttcaggacac gtacactgta acctagttgt aaccatttta ataaaagaag 224400 gttttgatca tttttgataa atgtactaca tgaatagtta acttgccttt cacttcctat 224460 accaacggaa attttggtaa caaatttaaa gaaagcatta ggttgaatat cccatctgat 224520 taaatgtcaa ctaaatattg tttctggctt ttaaaatatt tctaattcag ttataaaaca 224580 ggtctattac tcaggaggct gaggcaggaa aattgcttga accagggagt cggaggttgc 224640 agtgagccga gatcatgcca ttgcactcca gcctggcgac agagtgagat tccgtctcaa 224700 aaaaaaaaaa ggtgaaatga aaaacaaaaa agaggggtga aatttctctg cattctccct 224760 ttctgctgtt gggaaagccc tttcattacc aagaatgcat ggaattctgc ttattaattt 224820 ctccatctat gtgtctctgt gaaaaatact aattatttac aattttgtaa gctatgaata 224880 aggtctatgt tttctctgaa attatagcaa caggagcatt tcccccttat ttgggccgca 224940 atcttttcat tctgattctt accataactt ctgacttctg actttatcat gtcttctgat 225000 ttctactaaa catgaacaga atgaatgact tctagaaatg gatacaggtg taatacatat 225060 aaggccaggg aaccacttaa ttatctttac aaagtactag gacttcagaa aaatcaaatg 225120 atgaaatgga gctagcttta gtatgttcta cttatcattg gactattaat catgtctgtc 225180 tgatgagtta cctaggactt caactgtttt tatagattta aagaaaatat tataaatgta 225240 tcttacctgg atttaagact ggacagctga ttttggattt ttttctgcta ccctgttgtt 225300 gatatcactg acatcagcct ttgcattttg actggaggct cctttctctc tttctctctc 225360 tctctctctc tctctatagg aaaccagtag ttatgtcagg ttgctaagta ttttcccact 225420 gaaggacaaa tattctggag cagtatatat ttagcatttg acatttgata aacaagcttg 225480 tttgagatat tttcaataca atttcagctt tggcaattgt aagcaaagga tccagttggt 225540 aattggtgaa atgaacagat gtggacacgc tgcctgcatc gagatgcatt aatttttctg 225600 aaaagtggat aagatcttgt gagaatgaat aatggaattc aaatcagatg gggtgagata 225660 tttgatattc aggaacaaat cacagtataa tagatctgct actttgtttg gttttaatgg 225720 ggagttgcta atgctgaaat atagtcagag aaaaggaacg tggaatttct atagaggaga 225780 gcctggctct ggggtaatac tactgtcctt ggtggaatgt tgtcttttct gaagacattg 225840 gttcaattca atacatgaaa cattcatcga ttattattta gaaaagctaa tctactgaca 225900 agacacagag ttaagtagtg aaaatacaga gacctagaca cagttcttat taagaaattt 225960 tttaatttag gtggcatatt tcagagagaa attctctgct tggggcaata ggtacctcct 226020 ttggaataag catggtgaga aagaattgct tctggcagat tagtgagaag agtgagatat 226080 tttctttcga tgacctctct attaaaattt gagtggtaaa actttgtgat gattcaggct 226140 cttcataatt cttaatttta tcatcctcta ataccaggac ttgcccagat caatatttta 226200 ggaaacagtc atgcttgcta aacccaggga tttctattaa ccactagata agacataagt 226260 ttgtcatgca acaagtattt attgagtcca taatttgccc agcactgggc tttggtactc 226320 tgggccttga tactctaggt tgtgtcagag atgtctaata tatttaaggt gacagagttc 226380 acaaatgaga ctttatgaaa atgaatatcc ctttttaagt ctcgagaaat atgatgtgca 226440 cccgcttgag gctttattaa atctccagcg agcatgaact tgtttgtgac ccaattgtag 226500 aattgttgta tgatgactat cccactggca ggcacttctt gtccaagaga atgtaattgg 226560 atgttggtga ctcaagcaat cctgggaaga ctcctccatg accaaattaa agacaacagg 226620 ggcttggttt gtactcagct ctacaccaat cagcatgaga caaagaagag atccatggca 226680 aagtggggag actactgttt attttacaag ctagagaagg aaaactgcag ttcctgagtt 226740 gcaaaactgc taagaaatgg gagaacacag aactttacag gctgaacctt ggtgtcttag 226800 ttattcctct tggctacaga atgccaacca gtaggagatt catcactgag atattacagg 226860 gaaatgaagc caggcaagaa aaatatgtat tccctttctt ctcagcccat aaattttgtt 226920 attaataaat cagactctta tagaacagct tgccacggct gtctctagaa atgtttttat 226980 tagcagaatt tttattaaaa taaaatacac agtagtttta agagtgaaca ttatagtttt 227040 aggtcataag gggtgtcatg gagaacacat gtggatgcta cttgccagtt acttgatcta 227100 ggccttgact cttggttttc tgttgctcgg ataagttagc atgatttgac atgcagttaa 227160 aggtgtggta acctgtgatt gatttcccat tcttgatgct ccctgcctgg acttctcgga 227220 aaatttcaaa acaattcatt cttctatgag ggctgcctcc ttggttgctt cggctaaaca 227280 gtgttgagca acaagttggg aaaggaacgt tgcagtaact tttaaaaatt aagttagaaa 227340 caaatgtcat caaagtaaat gataatttgc caatatgatt gagcaaaaag atgaagatgc 227400 acgctcccta cgtatttgct ttgcagaaga attaatttga aaaataataa catattttaa 227460 aatgaattgt aaatataaac acatgctaat tgcagagggg aatccctgtg attattcagc 227520 agtttgtgtt tgtcaagtgc ttttcagtca gtccattcca gctcagcagg gcagaggctt 227580 gggctgttgt aaacttgtgg gcagataccc agtgatgggg cagacatgag caggtagggc 227640 tgacagcatg tgaattgagt tttcttcagt catgctgttg cagctgctcc cttccctcat 227700 tgctgagttt gccacagcag gtaggaacct aactctggag cctgggatga aggagaaccc 227760 acattgggct tgaggaacaa gatctgccac cctggtaggc cctggttaaa tctcatgcaa 227820 gtgtagcaat gagagagggt atgattgagt tctaatttag gaggaaaggg gataatgtgc 227880 cctttgcacc cccaggagaa atcattgctc atctgtgcct aagtagactt atcaagggca 227940 gttggttcac aatggtgtat caccccaaag gactatagtg ttatgagaac ttgccagtgt 228000 atttgaattt gggtgctggc agatgacatc atgaggtatt atggttaccc ataaatatgc 228060 tagtttattg agaaggtggt agacatgcta gtggatgaga gggaaggaca gaagcagtta 228120 gtaaacagca tctgcaacaa ttcagttaac tggtggttgt cacagtagca tggtggaaaa 228180 gttggcaatt aataacttct aagaaaactg aactaatgaa ccaatcctgc gtgtgctatg 228240 tgtataacct ccttctcact attaacagat ttgttccaaa cttatataag acaatgaaaa 228300 taaagcttgg caatataggg aagggatgga gggataaagc tgtaaatcac gtcacaggca 228360 aattaagata taccactgga tcaagggatt taatgcagaa agactgatcc taacttattt 228420 cttttattta gcaataagat ttgttactta cattgattat ttaaaatgag ttgcattatt 228480 agaaaggact attttgaaga caactataat aaaatgtcag taactgatag tagccaagat 228540 attttaaata tatcaaagtt gtgtcattaa tattaatgtg tcccttaata tgaagtcctg 228600 cccaggctta tttatgtatt caacagacac atacctgttg aagtgtaaca gatattctgg 228660 acacaagcaa tggtaaacaa gacagatgca gtccctgctt tcatgcaatt tgcaattgaa 228720 tggtctttga cattttattg tgattgtttt agttatttaa ttggagaagt ttttaattta 228780 aatttgtgtt atattcagtg ttaaggaaca aaaatgtaat gtgcatttct gagactcagt 228840 aacacttctg gtttttcctt tttcatttaa agaaaaattt agtgcccaag ataagctaga 228900 atttttggaa tcaagtaatt gatgacctgg gagccaattt tattacaata gtgtttttag 228960 tggtcttaga acttttcaga ggtggtagct ctgaaaataa cactgtaata aattcacaca 229020 tacatctatc atccaataaa tgttaattga ggcccactac agcattgtgt tagattctga 229080 ggttacaaat tgttgacccc atgtcgaaca tgttgacccc atcaatgtaa tcagtttgac 229140 attacacagt catttaaaca ttaaagtgtc agcggatatt ttagttgtaa ttttgataag 229200 tgctctgaag gagaaaacag tgggtgttgt gaaaagcagt atttggttga ttgattatta 229260 tagaggatct gagaaaactt acttgaggaa ggaacatttg gctgaactca aagagatgag 229320 taggagttaa gtaagcaagg aagaaaagaa gacacatgaa ggaggaagaa tgttctagaa 229380 acacacacac acaggtatat gtatatgtac atgtatatgt atatgcatat gtcttcctta 229440 gaaacatata aacagctgca acatgattga acttatttac ccaattacca aagcttattt 229500 tgcaccatga aggtggagat aaaggctttt taagcagcaa ggatagaatc tttgtagttt 229560 ttatttatag gctggttctt ctgacaactt taatttttca tctttaccaa cttcatggtc 229620 ttcagtacat acaatgcaat cattattata aaattatatt ttgactcaaa ctctaaggta 229680 ggatgattca gctgtgcgcc atcaacatag cagcatgaat ggtagagact agtcattcca 229740 aacagtgaag gggcaacgta aaactaattt taatattata tgaaagtact tcttgccctt 229800 gactgctttt tttttttttt gaagaaagca aactttaaaa atttatttta gatttacaga 229860 attattgcaa ggatagtaag agagttctca tatatgcctc acccagtttc ctctattatc 229920 gacatcttac attatatggt acatctatca taactaatga accaatattg tttcattatt 229980 agtaactaaa tctatacttt attcagattt tctaagtttt cctctaatgt tctttttctg 230040 tcccaggacc ccatcaggat atggtatgta tagttgtcat gtcttcccag gctcgccatg 230100 gttgtgacag tttctgagac tttcattgtt tttgataccc caggtagttt aggcattttg 230160 tagaatgcct cccagtctga atttgtctga tgttttcctc atggtttgac tggctttaat 230220 gtgttttggg gaggaagacc acagaggtta agtgtgattg tcatcacatc gtatcaaggg 230280 tacatgccat caatatgact tatcactgtt gatattaacc ttgatcatct ggcttgagat 230340 agtatttgtc aggtttctgt attatacagt tactcttctc cctgtccata cagtactttt 230400 tggaagaagc cattttgtgc agctcatttt ttttttaatt ttaattttaa gttctggggt 230460 acatgtgcag catgtgcatg tttgttacat agttaaacgt gtgccatggt ggtttgctgc 230520 acccgtcagc tcatcaccta ggcattaaag ccaacatgca ttagttgttt ttcctaatgc 230580 tctccctccc ccaaccccaa tctgacaggt cccagtgtgt gttgttcccc tccctgtgtc 230640 catgtgttct cattgttcag ctcccacttc taagtgagaa catgtggtgt ttgggtctct 230700 gttcctgcat tagtttgctg aggataatgg cttccagctc catccatgtc tctgcaaagg 230760 atttgatatc cttccttttt atggctgcat agtattccat ggggtttatg taccacattt 230820 tctttatcca gtctatcact gataggcatt tggtttgatt ccatgccttt actattgtga 230880 atagtgctgc agtgaacata tgcatacatg tatctttgta atagagtgat ttatatttca 230940 ctgggtatat acccagtaat gggattgcca ggttgaatgg tatttctagt tctagatctt 231000 tgaggaattg ctacaccatc ttcctcaatg gttgaactaa ttaatttaca ttccgaccaa 231060 cagtgtaaaa gtgttcctat ttctttgcaa cctcgccagc atctgttgtt tcttggcttt 231120 ttaatgatca ccattctgac tggtgtgaga tggtatctca ttgtggtttt gatttgcatt 231180 tctctaatga tcagtgatgt tgagcttttt tcatatgttc tttggcctca tgaatgtctt 231240 cttttgaaaa gtgtctgttc atgtcctctt ccaacttttt aatagggttg tttgtctttt 231300 cttgcaaatt tgtctaagtt ccttgtagat tctggatatt aaacctttgt cagatgtata 231360 gattgcaaaa aatttccccc agtctgtagg ttgcctgttt tctctgatga ttgtttcttt 231420 tgctgtacag aagatcttta gtttaattag atcccatttg tcaattttgg cttttttttg 231480 caattgcttt tggcagtttt gtcatgaaat ctttgcctgt gcctatatat ttattgcata 231540 gattttcttc taggggactt caaactatgc tacaaaactt caataaccaa aacagcatgg 231600 tactggtaca aatacagaca catagaccaa tggaacagaa tagagaactc agaaataaga 231660 ccacacatct acaacgattt gaccttcgag aaacatgacc aaaacaagca atggggaaag 231720 gattgcctat ttaataaatg gtgctgggag aactggctag ccacatacag aaaattgaaa 231780 ctggacccct tccttacacc ttatacaaaa attaattcaa gatggattaa agacttaagt 231840 ggagctcata tttaaggagt gagaagatat gctctacctc tttaagggtg gagtagctct 231900 ataaattatt tggaagtgtc tattctcctc cattaattta tttagtcaac aattagtatc 231960 agccatctag aacccatgaa tatttatgct ttgggtacag tccaatacta ttttattttg 232020 tagctcatct tgttccagct ttggccattt ggagattttt cagttggctc ctgtatctct 232080 ttggcttctt acatatcatt gtagggtttt ttaaaagcct tttcttactt tctgtcacta 232140 caagatagtt cagacttatc ttctgtattt tttgccccag ttctatgatc agccacttct 232200 ccaaggagca ataatttcct tcaatgaaaa ccaagatatg ggctgttggt gtacttgttg 232260 ttattgtgtg ttgttacttc tagatcctct aagctgatag tgcaaagaga tatatgtgtg 232320 tgtaccaacc tatatatcta cacacatata aaaatatttc tatttgtaac catctgtatc 232380 tatcttaggc taaacctgag tacctactga tgtctccaat tctaacctgc aacagcatgg 232440 aacattctag ccttctcctc ttacttatct gtcacttcct ataccaatag tgagaaacct 232500 ggctcctacc atctgctatt tatttactta attatttaat tccactatac ttctatggaa 232560 gtttcagaat tgttaatctg tactcatgta cgaaacaact ttatcaacta gagtatagtg 232620 tttatataca gttcctttgc ctttattcta acagattcca cttactcatt ttccgagtca 232680 cttaggttag cgccttattt tcctaagtcc attagtgagt ttgcttcatg tatttgtcat 232740 acatttaaat tcttttgtaa tattgtgcat tccatcccag tttcccctga catcctaaat 232800 taacttttta agtttggata cattgtggtc tattctttgt tctgtaaagc tttatggatt 232860 ttgacaagta tttaatgtat tgtatcacca ttatagtaat atagttccta tggaatagaa 232920 tagtttctat cgctgtagca tagaatagtt tctctactct ataaaatatc ctgtgtttct 232980 ctaattcaac ccctccttcc caccttgaac tcctgacaac ccctggtctg tttaatatct 233040 ttcttttgtc tcttctagaa tatcatataa ttgaaatcat acaatatgta gctttttcag 233100 actggctact ttcacttagc aatattcatg taagtttcat ctatatattt tcatggtctg 233160 atagctcatt tctttttaat cactgaataa tacttttatt tatccactca ctggtgaaga 233220 atctcttgat tgcttctaaa ttcatggcaa ttatgaatga aactgctcta aacatttttg 233280 tgcaggtttt tgtgtgcatg tgtattttca aattagttgg gtaaatatct aggaattcaa 233340 tttctgcatc attgtggtaa taatgtgttt agcttcataa gaaattgcca acctatcttc 233400 caaaatagct gtaccatttt gcattcccac cagcaatgaa tgagagttct tgatgctcga 233460 catccttgtc agcatttgat ttttgtcagt gttttggatt ttaactattg taatagatgt 233520 gtagtagtgt ttgattgttt taatttgcaa tttctttttc ttttttgaga tggagtctcg 233580 ctctgtcgcc caggctggag tgcagtggca cgatcttcgc tcattgcaac ctctgcctcc 233640 tgggttcaag caattctctg cctcaagctc ccaagtacct gggattacag gcgcctgcca 233700 ccatacccgg ctaattgttg tatttttagt agagatgggg tttcaccata ttggccaggc 233760 tggtcttgaa ctcctgacct tgtgatccac ccgccctggc ctcccaaagt gctgggatta 233820 cagacataag ccacggcgtc cggcctgcaa tttcttaatg acaaaaaata ttgaggatat 233880 tttcacatac tttttttgcc aactgtattt tttttaatta atttttattt ttattttatt 233940 ttgtaacttt tattttagat ttggggtaca tatgtacatt tgttaataca ggcaaatttg 234000 tgtcacaggg gtttggtgta cagatcatct cgtcacccag gtactaagca tagttcttga 234060 tagttctttt tcctgatcct ctccccactc ccactctgtt ccctcacgta ggccccagtg 234120 tctcttgttc ccctctttat gcccattggt tctcattatt tatctctcac ttaaaagtga 234180 gaacatgcag tatttggttt tccactcctg cattagtttg ctaaggataa tgtcctccag 234240 ctccatcctt gttcctgtac aggacatgct ctcgtgtttt ttttctttct ttttatttta 234300 atggctgaat agtattccac ggtgtctatg tactacattg ttttttttta aaccctgcat 234360 accattgatg ggcatttagg ttgattccat gtttttgcta ttgtgaatgg tgttgcaatg 234420 aacctacatg tgcatgtgtc tttatggtag aacaatttat attccactgg gcatataccc 234480 aggaatggga ttgctgggtt gaatggtaat tctcctttta ggtctttgag ggatttccac 234540 actgctttcc acaatgggtg aactaattta cactcccacc agcagtgtat aagtcttccc 234600 ttttctccat aacctcccca gcatctggtt ttttttgttt gtttgtttgt ttttttagta 234660 tttaataata gccattctga ctggtgtgag atgatatctc atcatggctt taatttacat 234720 ttctctaatg attagtgata tgtagcattt tttcatttgt tgccaactgt atgtattttt 234780 caatgaggtg tacatcagat cttttgccca ttttaaaagt ggggttttgg gctgggcgca 234840 gtggctcacg cctgtaatcc cagcactttg ggaagctgag gcaggcagat cacctgaggt 234900 caggagttcg agaccattct ggccaacatg gtgaaaccct gtctctacta aaaatacaaa 234960 aattagtcgg acatggtgtc gggcacttgt aatcccagct acttgggagg ctgaggcagg 235020 agaatcactg gaacccagga ggtggaggtt gcagtcagct gagactgaac cattgcactc 235080 cagtctgggc aacaagaatg aaactccatc tcaaaataca tacatacata catacgtaca 235140 tacataaaat tgggtttttg ttttcttttt gttgagtttg aggagttttt ttgtatattt 235200 tgattacaag tcttttatca gccatgtgtt tcacaaataa tttctcccag tttgtggctt 235260 atcttttcac tctcttaatt gtttttttca aagtagaaat ttaaatttta atgaagccca 235320 atttattaat ttttttcttc catattgtgc tattggtgtt gtatataaaa acttactacc 235380 aaattcaata tcatatagaa ttttttctgt tttcttcaag aagtagtttt ataattttgc 235440 attatatgtt tagatcaatg attcacctta agttttgttt aaggtgtaag gtttgtgtat 235500 aagtttttct ttttccacat caatgtccag ttgcttcagc aacattttct ttttatatat 235560 atcttaaggg taatcagcgc aatattttct gaaaagatga cctttttctc atttaattgg 235620 ctcttctttg tcaaagatca gttgacctta tttgtgtgga tctatttctg gacttcttac 235680 tctgtttcac tagtccatct gtttatactt taaccagtac catactgcct ttattactgt 235740 agcctttatg gtaagtcttg aaatgaaata gtgcaagtgc tccaccttct tcagaatttt 235800 gttcttcttc agtattaaag gctattctag gtcttttgcc cttctttaaa catgttggaa 235860 tcaattgtca atatctacaa aatagattat tgggatttgg atttagatta ctctgaatct 235920 gttaattaag ttgggaagaa ttgacatttt atcaatattg aataatatga acatgtaata 235980 atattgaact ttcaatctct attatctctt catcatttta agatcttctt tcatttttca 236040 ttgttttata gatttttaca tataggcctt gtacatactt tgttaattta tatcttagta 236100 ttgaatgtac tattataaat ggtattttct aaactttgaa ttcctgttat tcatgatgat 236160 atgtaggaaa gaaattgact tttgtatatt gacattagat cctttaaccg tggcatcatt 236220 acttattagt tccaggggag attttgttgt tgttgttgat tcattggaat tttctgcata 236280 gataatcatg ccatctgtga ataaagatgt tttatttctt ccttcccaat ctatatatct 236340 tttatttctt tttttgcctt attgcacttg ctggtatttc tagcataatg tataatagga 236400 ggaatgagat aagatatctt agaattatcc tcatcttcag gggaaagtgg ttagtttttt 236460 gtcattaaga ataatgttag ctattgtttt tttaaatttc ctatatgaaa ttgaggaaat 236520 ttctgtctat tctgaatttg ctgagttttt aatcataaat agctgttgaa ttttgtcaaa 236580 tagttttcct gtgtcaatta atatgatcat atgacttttc ccgttttcac tgttaatgtg 236640 gcagattata ttgatttatt ttcaaatgtt gaatttgcca tcagacatgg aataaatccc 236700 atttgttcat gatgtataat ttattttatg catcgtttgt tctgtcttgc taacattttg 236760 ttgagatttt gtgccagtgc tcaggagaga tattggtctc tagttttact ttcttataat 236820 atctttatct gatttgggta ttaggataat tctagactca gaatgagtta ggatgtgttt 236880 tctctgcctg tttactaaca cagattgtag agaattggca caatttcttt cttgaagatt 236940 tgttagaagt aatcttgcca ccacctgagc cagatgattt ctttagaagg taattagtta 237000 ttgaatcaat atatttaata tatatagaga tatttaggct atttatttct ccatgtgtga 237060 gttttggtag tttgtgtatt tcaaggaatt ggtccatttc atccaaatta tcaaattcgt 237120 gagcatagag ttgttcataa tattccttta ttatcctttt aatctccaag agaccagtcg 237180 tggtgacttc tctttcattt atgatattgg taatttatgt tttctgtctc tctttttttt 237240 ttgccagagt ctaactctgc cacccaggct ggagtgcaat ggtgtgatct ctgctcactg 237300 caacctctgc ctcttgggtt caagtgattc tcatgtgtca gcctcccgag tagctggtat 237360 tacaggcatg ctccaataca cttggctaat tttttttttt gtatttttag tagagatgaa 237420 gttttaccat gctggccagg ttggtcttga actcctggcc tcaagtgctc tgcctgcctc 237480 ggcctcccaa agtgctagga ttacaggcgt gagccaccgt gcccggcttc tttttcttaa 237540 ttagcctgaa tagaagttta tcaattttat tgctctttta aaataaccag tttttgtttc 237600 actgagtttc tttatcatgt ttctgttttc aattttattg gcatctgctc taatttcaga 237660 tgctccttga cttatgatgg ggttgtgtcc cagtacatcc actgtaattt gaaaatatca 237720 taagtctttt gacttatgta atgcatctaa cctaccaaac attatcgctt agcctaacct 237780 cccttaaatg tgctcagaac acatacatta gcctacagtt gagcaaaatg atctggcaac 237840 aaaacacact atagagtatt gatggtttac cccgatgatc acatagctga ctgagagctg 237900 cggcttgctg ctgctgccca gcattaagtg agagtattgt tccatatatt gctagcacag 237960 aagatctaaa ttgaaaattc aaaatacagt ttctactgaa tgcatgcata ttacttttgc 238020 accattgtga agtcaaaaaa aataataaat caaaccatct taagttggga actgtctata 238080 ttattctttc tcttctgctt gctttaagct tatctagttt ttttcttctc tagtttcctt 238140 aggtggtggc ttaggttggt tattgatatt atatattttt cttatctaat atatttactt 238200 aatgctatga atttttctct aagcactgct tttcctgcat cccacaaatt ttgatgttct 238260 atttttatct tcatttagct caaaatagtt taccatttat tttgaggctt tttctttgac 238320 tcatacgttc tttaaaagtg tgttgttcaa tctctaaata tttcgatatt ttccagctat 238380 ctttctgttg atttctaatt tatttccaat ttggtgtgag agcctacttt gtacactttc 238440 tgttctttta aatttgttaa gggtgttttg tgacccagaa tgtggtctat cttggtgcgt 238500 attccatcag aacttgagaa gaatgtgtat taagttgtgg tttgatggag tattctataa 238560 atattaatta gaccatgttg attcatcata ccgtttaggt caactatatc tgtattaatt 238620 ttctgcctgc ttgcactagc aattactgac agcggaatgg tgaggtttct aagtataata 238680 atggtttggg cttgtctatt tcccctttta gtttcaatca ttttgcttca tgtgttttga 238740 ttcacttttg ttaggtatac acatatatac acatatttat gattgttgta tcatcttgaa 238800 caactgaccc ctttatcatc atctttatcc ttggtacttt tccttctttg gtagtctgct 238860 ttgcatgaaa ttaatatagc cactccagct ttatttttgt gaatgttagc atggtgtatc 238920 tttctccatt cctttacttt taacatatca gagttattac atttaaagtg ggcattatta 238980 ctaggataaa taccaaataa agtattttgc atgctgggct taaaacctag atgacaggtt 239040 aataggtgca gcaaaccacc atggcacatg tatacttatg gaacaaaact gcacattctg 239100 cacatgtatc ccagaattta aagtaaaata aaaaataaat aaataaaaat taaaaagtaa 239160 aaataaatta gctgggtgtg gaggcagcca gctactcagg gggctgaggc aggagaatca 239220 aaataaataa atcaataagt ggggcttttt gtagacaaca tatagtttgg tctttcttaa 239280 aattcaatct gacaatttcc atcttttaac tggtatattt aaacaattta tatttaaagc 239340 aagtgttgat atatttgaat aaaaataaac ctgtgtttat taactatttc atatttgttg 239400 ccaaacgctt ctttttggtc tttcgtagtt ttatttgagc aatgtatgtc ataccatttt 239460 atcttttctc ttagagtatt aactatactt cttttttttt tttttgagac agagttttcc 239520 tcttgttgcc caggcgggag tgcaatggtg cgatcttggc ttaccgcaac ctctgcctcc 239580 tgggttcaag cgattctcct gcctcagtct cccgaatagc tggaattaca ggcatgtgcc 239640 accatgcccg gctaattttg tatttttagt agagacggag tttctccatg ttggtcaggc 239700 tggggtctta aactcctgac ctcaggtgat ccaccggcct ctgcctccca aagtgctggg 239760 tttacaggag tgagccaccg cacccggctt aactatactt ctttaaagaa tttttgtagt 239820 ggtgccgcta aagttcacag tatacatttt taagtattct aaatacacct tcaaataaca 239880 ctattccttt ttacatgaaa tatagggata ttataacata gtattctcaa ttcctcctta 239940 ctgtcccttg tgacatagct gtcatttatt tcatttcact tacctatata ctataatcac 240000 ctatacattg ctgctattat gattttaaac aggcagttat tgtttacgtc aattaagaat 240060 ttagaaagaa tttagaatcc tgtgtaaaat aaatttcctt ttattttacc ttaattcatg 240120 cattctctga ttatcttcca tgctttatgt agatccaagt ttctgactta tatcaccttc 240180 ctcttgcttg aagaacatct tttaacatat tctgcagggc aagtcagctg gtgatgaatt 240240 ctctgaattt ttgtctgatt tttttttaat atttccttca cttttgaagg ataatttccc 240300 tgcatctaga attctaaatt ggtcactttt ttcaacattt tatatatttt acttcacttt 240360 ctttattaat gtacggtttc tgaagagaaa tctgctgtat ttcatcctgt tctctatggt 240420 taggtgcttc cctgccctgg ctctggcttt ttcaagattt tctccctgtc tttggttttt 240480 ctacagtttg aatacaatat gcctaggtgt tgtttgtttt gtttttttgt aaggagtggc 240540 atgtatttat cttcttgata ctccctgagc ttcctggatc tgtggtttgg tgtctgtcat 240600 taattttgaa aagttctcag ccattactac ctcaaatatt tcttcttcgc ctttcttttt 240660 ttttctttct ggtattccaa ttatgcatat gcttgttata ccttttgctt tttcattctt 240720 ttgattcttt acatttcagt tggggacgtt tctgttgact tatctttcag ctcactgatt 240780 atttccttgg ccgtgttgaa tcaattgatt agtcctcaaa gacatttttc atttctgtta 240840 caccattttt acatttctag catttgcttt tgattctttc ttaaaatttc tatctttctg 240900 cttatattac ccatctttta ttgtatgttg tcttcttttt ccattagagc cctcaaactc 240960 ttttttttta ttatacttta agttttaggg tacatgtgca cattgtgcag gttagttaca 241020 tatgtataca tgtgccatgc ttgtgcgctg cacccactaa ctcgtcatct agcattaggt 241080 atatctccca atgctatccc tcccccctcc ccccacccca caacactccc cagagtgtga 241140 tattcccctt cctgtgtcca tgtgatctca ttgttcagtt cccacctatg agtgagaata 241200 tgcggtgttt ggttttttgt tcttgcgata gtttactgag aatgatgatt tccaatttca 241260 tccatgtccc tacaaaggac atgaactcat cattttttat ggctgcatag tattccgtgg 241320 tgtatatgtg ccacattttc ttaatccagt ctatcattgt tggacatttg ggttggttcc 241380 aagtctttgc tattgtgaat aatgccgcaa taaacatacg tgtgcatgtg tctttatagc 241440 agcatgattt atagtcattt gggcatatac ccagtaatgg gatagctggg tcaaatggta 241500 tttctagttc tagatccctg aggaatcgcc acactgactt ccacaatggt tgaactagtt 241560 tacagtccca ccaacagtgt aaaagtcttc ctatttctcc acatcctctc cagcacctgt 241620 tgtttcctga ctttttaatg attgccattc taactggtgt gagatggtat ctcattgtgg 241680 ttttgatttg catttctctg atggctagtg atgatgagca ttttttcatg tgtctgttgg 241740 ctgcataaat gtcttctttt gagaagtgtc tgttcatgtc ctttgcccac tttttgatgg 241800 ggttgtttgt ttttttcttg taaatttgtt tgagttcatt gtagattctg gatattagcc 241860 ctttgtcaga tgagtaggtt gcgaaaattt tctcccattt tgtaggttgc ctgttcactc 241920 tgatggtagt ttcttttgct gtgcagaagc tctttagttt aattagatcc catttgtcaa 241980 ttttggcttt tgttgccatt gcttttggtg ttttggacat gaagtccttg cccatgccta 242040 tgtcctgaat ggtaatgcct aggttttctt ctagggtttt tatggtttta ggtctaacgt 242100 ttaaatcttt aatccatctt gaattgattt ttgtataagg tgtaaggaag ggatccagtt 242160 tcagctttct acatatggct agccagtttt cccagcacca tttattaaat agggaatcct 242220 ttccctgttg cttgtttttc tcaggtttgt caaagatcag atagttgtag gtatgcggcg 242280 ttatttctga gggctctgtt ctgttccatt gatctatatc tctgttttgg taccagtacc 242340 atgctgtttt ggttactgta gccttgtagt atagtttgaa gtcaggtagt gtgatgcctc 242400 cagctttgtt cttttggctt aggattgact tggcgatgtg ggctcttttt tggttccata 242460 tgaactttaa agtagttttt tccaattctg tgaagaaaga tattggtagc ttgatgggga 242520 tggcattgaa tctgtaaatt accttgggca gtatggccat tttcacgata ttgattcttc 242580 ctacccatga gcatggaatg ttcttccgtt tgtttgtatc ctcttttatt tcattgagca 242640 gtggtttgta gttctccttg aagaggtcct tcacatccct tgtaagttgt attcctaggt 242700 attttattct ctttgaagca attgtgaatg ggagttcact catgatttgg ctctctgttt 242760 gtctgttgtt ggtgtataag aatgcttgtg atttttgtac attgattttg tatcctgaga 242820 ctttgctgaa gttgcttatc agctgaagga gattttgggc tgagacaatg gggttttcta 242880 gatatacaat catgtcgtct gcaaacaggg acaatttgac ttcctctttt cctaattgaa 242940 taccctttat ttccttctcc tgcctaattg ccctggccag aacttccaac actatgttga 243000 ataggagcgg tgagagaggg catccctgtc ttgtgccagt tttcaaaggg aatgcttcca 243060 gtttttgccc attcagtatg atattggctg tgggtttgtc atagatagct cttattattt 243120 tgacatacgt cccatcaata cctaatttat tgggagtttt tagcatgaag agttgttgaa 243180 ttttgtcaaa ggctttttct gcatctattg agataatcat gtggtttttg tctttgtaga 243240 gccctcaaat tcctaatcac aattgtttat ctctttcctg acattccaca tccaatccat 243300 cagcatgtct tattggcttt actttcaaaa taaattaaac tcagccactt ctcagcattt 243360 ttaaaatcac cctaatacaa accccctgct acctcatcaa ctgcaatggc ttcctaactt 243420 attttgtaac ttttgatctt tgagttcttc caagagccaa gagttcttcc aaagctataa 243480 accctatcat tggcactcct ctgctctatg gaaagcagtg gcttctcatc tctttcagag 243540 tataatgcaa agctctcacc ttagctggca tggccctgtg ggattggcct cccttgtctt 243600 actttttcct tgttcaggct gctgtgacct ctctggtctt tggctcttac tagaaacctt 243660 tgaacccgtt tccttcccag tgtcagtatt tgtgtgttgt tcgttcaccc ttctcacttc 243720 attctggttt ctacagcaca gagaagtagt agtccctgat ctaaacaccc tctccacctg 243780 ctttccactt tgttttttcc cctagcactt accattatca gatatcatat atttatttgt 243840 ttattgtcta acttcctcac aaaaatatga cgttgtgagg atagggattt ggctttttgc 243900 cccagagcag tgcctgactc tcaataactt tgttgtatta agtgaatgaa taaaataaaa 243960 ttaaaattga ttcaaagtgt atgagcatgt gtacatttta cataagtgat acatgacatt 244020 cttccattcc ttgggggctc ttttaaccat tctcaaccag ttgtagtacc tttaaaaaat 244080 catgatgaag atgattttga gagctaattt tggtaggaga cagcagtttt agcctgtccg 244140 ctccatgtgc agaataatag cctattttat tacatctgat attcaagcac tagaatctat 244200 caataggtaa ataatttcca aaaataaaag catcagtggg aaaacaggga aattattttt 244260 aaaaaagaat ttctagacca ggatgtgtgc aatttgtaat ctctaataag aaacgttata 244320 gctgataatt ccagcaatta cagaatcatg atcatatcca taatggatca gtagaggctc 244380 tggcttatat aatagcttgc cctctcagga ttctagagcc ccatatgtaa acacagaaca 244440 catttatatt gattgacagt gcatgtaggt ttctacagat tgtgccagtc agtgttttct 244500 aaggcagtta tgccatggta attaaaatta tgggctctga aatcagcctg cctgggttca 244560 aaccccagct tcatgtgtca gcttccttgg ctgtaataag gaatactaat agcacctgcc 244620 ttgtggcttt gaaaattaca tgatgtaact ttgtcaagag cttagatgag cacttgggat 244680 atggcgagtg ctcaataaat gttagtttac catcatcatc atcattatta ttattactga 244740 ttgcaagcaa gacaaactgg ttctcacttc agcagaaaaa gaaattactg aagtaatttt 244800 ggttagatca cagatttaac gtgaaggatg aataaccaga cttggaaaac aggtggaaac 244860 caagaggcag tcagcatggc atagcagcca gcacttcacc agtgtggtgc cttgggggca 244920 gcctggcagg agccactgcc ttcactcctg gactgcagat ctaccacagg acagcagact 244980 gaattgtcct atgtccagac ttcacagtca cagggagcag gctgcatgca ggtggggccc 245040 aggtcaccta ccttcaccct agagtctgga gccacagaaa acagtaattg tccttgtagc 245100 ttttgtgatg gaaagcaagt cctgacaccc accaactcac atactaggga attcaccaaa 245160 tgtaggacgg cagctaagat gctgggaaac caagaattaa caaatgagta ttacaccaat 245220 tagttaattc attacagatt tcaatatttt ccaaaaaaca tcctacaaag aacagctcac 245280 tttaatatac tccaacaaat gatgaaatct ctccttggtc atcagctttt ctaaatttct 245340 gtaactttag gtgattctga atttcttagt gattctgaac ttctagaaga ttctgaaaca 245400 gaacagtctt actttgggat gtattcaaat cctagagatc agtcacatca atctgtgccc 245460 tttttcatta tgtaacatga aacaggagga cctttccaac ttgccttggg aacctgctcc 245520 tacaacaggg tatattatca catttaataa agaaagagta atatttgcat tgtgaccctt 245580 catctgaggt catcgggact gtgctgtcct cccaagctcc actgtaaagg gatagacaac 245640 aaccttgtct cccagtcatt gtaatctgta tcagagagca tcattagatg aatgaagatg 245700 gaaatgttct cacggtcagc aggtggggaa ggcaagactt gctgattgga agcaatgaac 245760 catagttcat tctaaggctt ggggagagca actttgagga aatgaggccc ctaaacttgc 245820 catgtaggag aagttggggg gtggtaaatt gggcaccctt tatctactaa acgtaatctt 245880 tacttcccca ccctctaatt tttctcagtt gggcttgaaa ttgtttttgc ttgttacact 245940 ttatgggaaa agaaagggaa atcctaataa ggtccatgcc agcaaaactc tagaagaaga 246000 aactaagaat ttcaaattga cagtttgtta atgagaaaag acaaggttaa aggattttgt 246060 taaacagatg accaaaataa ttattggaaa cttctgcttc tggccaaggt ggaataataa 246120 gggctacatt taccttccca ccagaaaata taataacaaa caaaaactgg acaaaacact 246180 ggacatgaca ctgttgtctt taaaccttgg acatcaatca gtgcaggatg ttattttgta 246240 agaaagggaa aaaaattggg gtgagccttc tgattgtttc cagactggag agaagtttca 246300 ggccacagca agtggggagg aacctaggtg taagtatatg tataaggtag cacatcatag 246360 tggccaaatg aatggcacag gaaagaaaaa ctacaagaac agaggaggta gggccacaaa 246420 actagagtgg ggtccaagat tcactatgga taaaatgggg tgttaatttg gttttcaagg 246480 ccaatacaag aggaggcata gaaaaagaac aaggtggtgt tgggaagtag tataaaaagg 246540 ggcacaggct tatccttgtt ttataaaaaa caaaggtttt tggaagggat ttgtagagat 246600 aagtttgaaa agtagtttga gactatgtgt ggaaattcat gaatcttaga gtttgatttt 246660 attcaggaga tcagtagctt ttaaaatgta aaataaaacc agtaaactct atctaaaata 246720 aattcttccc ctaatcccaa tataaaaaat acatataaaa gcgtagctgc tctagacaaa 246780 atggcgggta tgagatgacc agaaacctca acagcactac ctctggtagc cccatagaac 246840 tgccaagagt tttcagagta tagttaattc ctgctgacgg ctaaggcagt cattgagtga 246900 ttggaaagaa gacggaagat agacaagatc agttaattgg gttggaggga agactgaaga 246960 taggcaaggt gacaaattag gaactgttgc aatgatctag gcaagaagga acctatgaac 247020 taggagggag gcttaaagac agcaaggagg gaactatagg cagggacatg tgaggaaatg 247080 cttagtagtt aaggtgagtt tgtaggtatg aaaggagaga aggaaagaac attaagtagc 247140 attaagtgaa ccagataatt tatagctcct tgacctgaaa catttagagg ctgtgataac 247200 actaataata ataatctata attacataaa ttacgtagtg taatgatata tcatgatata 247260 atcatcttac caatgcttta cagtcaatga cattgtggta cagagacttt ggaggcagat 247320 agacctcgat tgtaacctct gtgctgcccg tggtatgacc ttgagcatgg tagttaatct 247380 gaacttcttt cttttctgtt aaattgggga caatgacagt acttaacctt atagtacttg 247440 aagggagagt gttagaattg atactgggga gtctctccac agaaagttgt attagttatt 247500 gtctttattt cattcttaat gaattagcac tcccgttttc tttaacatgt tgaatttaaa 247560 acctcttagt gtatttcttt gtcttgcctt ttaatacccc atgaattatt gagaaacaaa 247620 agaaagtgat tatgcaaatg tttgaaatat ctaataatac atgaacgtag tcatgggaaa 247680 ctggagaaat aactttactg atattatact agtttttttt ctggaagcat agcatattaa 247740 gaaaactcat ttcaatgaaa gaaaatttaa aaattagagt gcattagaag cataatccaa 247800 tgaattctat tcctaatgaa tactcaggca gtatgttaac tttttctgag atacaatagc 247860 caagccaaag aatttaaaga atgaaaaaaa cagatgatta aacaaactgt gaagtaatta 247920 gaggtagtct ttgaaaatgc ctcattaggc atttgactca ttaggacaga tccttttatt 247980 ttagggccag gacataatta tttaagcagt tgatgtgtct ttagctcctt tcaccttgcc 248040 acaagttgtc gcctgtactg cctttccacc tagcttccaa gtccaggccg actttgaaga 248100 gattccttag ggctcacctc ccctggagag tgccctctgt accatctctc tccctttcct 248160 cctcattcct attgcctgag tttattgttt taataaattc ccataagtta acacctccta 248220 gggtggatta gaatcattca aatccacatt gattgttact aagtagaaat tttatactga 248280 gcctttctaa atccttacaa caacgtgacg aggatattat agttgcttta acccaaggag 248340 atgaaattca aactggtggc attgcacact tacagtgggc ttgcaggatg aaagagagct 248400 tggtatctcg atcccttata caaaacaggt gggtcttgtt agaaaaattc ttcaataatt 248460 gttaaggtta aaattttgaa aagtggttca aagaaatttg ctttgatgca aatattgtct 248520 agtcagttac ataacttgag ctataatgac agtgtacact agctatccag ggcacgacat 248580 ctctattgtg ctgttgaata tactgctcaa ccattctgga aaatggcatg ttcatgtatg 248640 aatgacaatg tatcttgtgt gtatggcatt ccaagccaac atgttggtcc ctgcaagtaa 248700 acttcttgac tgtcaagagg ctgcctgttt aatatttgca tgatctaaac taattgtttc 248760 ctttgttttt ttcctctgct ttatgagctg gtagtttgac cttttggctt ttcccctgag 248820 agttaacaaa agttagacag ttggggggtg aacttaagta aaatccatat cactctatgt 248880 tgctgctcta ctaacaattc aagaaaatgt cttggtagaa agcaaggaat gagttttaaa 248940 ttttctcttt gaatttcaat tatccatgcc actcctgtgg tccaccattc tatataatta 249000 agaataagct gtatgttcca tagtgacaca ggctgttatt tctgatttgc agttttcact 249060 taacctaggg taaaattgaa atagaagtcg catccttttt tttttacctt cttccactca 249120 attctagtta gatatttttg aacttctata aaatgtctat gcaatattat caccaataat 249180 gtgcaaaatt actactccca tgtagaagag gatccattct tcattgaacc atacccttgg 249240 gatcctatca catgcagttg gccatataat attttatatt attgtttttt tgttttgttt 249300 gttaagtttg tacctacata atggattaaa ttcaaaatct ctgtttaact gaaacaaaat 249360 ctgtttaact gaagcaaaaa aacaaaatct ctgttttttg tttgtacaaa acaaaaaaca 249420 ataatatttt tgttttgttt gtatacttca tagggacttt ggaatttgga aaatatcgtt 249480 catttagggt atatatatta gtccattttc atactgctat aaagaaatac ttgagactgg 249540 gtaatttata aagaaaaata ggcttaatga actcacagtt ccacatggct ggggaggcct 249600 cacagtcatg gcagaaggtg aaggggaagc aaaggcatgt cttatatggc agcaggcaag 249660 agagtatatg caagggaact gccctgtatg aaaccatcag atctcatgag acttatttac 249720 tatcatgaga acagcacagg aaaaacctgc ccccatgatt cagttacctc ccactgagtc 249780 cctcccacat gtggggatta tgggaactac aattcaagat gagatttgga tggggacaca 249840 gccaaaccat atcagtacat taaagaaaat atttgttagc gctaagtgaa tctactttca 249900 cctacttgat tatttgatga ttttataaat agtcatctct ttcctcatct ttccagtcgt 249960 attttgttgt tccaaagcca aaacctgtgt gtcttgtatt caacaacctg aatcatacag 250020 ttgtgagacg taaatgggtg tggtggttcc acttacttct ttacatagta ctacaactaa 250080 gccatctaag tagtctgctc ctaaattcct ccaagaaggg aaatatcatg atttgattta 250140 aatgtgacat cctttcttag agaagttttc tttgtctcct tcttccccag tcacttcctc 250200 ccatccactg tgctttcggc agttcattcg ttcattaatt cattcaacga atattgaata 250260 acttttgatc aatgtcttcc tccctccaag ctgaaaactt gatggagggt aacatgatct 250320 gtctttgttt accactgcat cttccgtgaa tatacattgt aagtattgaa cggattttta 250380 ctaaatgaac aaatactttg ataaaatatt tttgattact gccaatatca gtttctgaat 250440 tgattctaaa attcttctgc tggaaagtag attagcgtta gtatgactgc tgaagccttt 250500 taaagtgggt ggtaatacta cgtttcgttt tgtttcatta acctaagtgc tgttctttgg 250560 aatcttttta aagtaagata aattacattc atgaaagaag catattattt ttaaagtact 250620 ttattttgga aaggtaaaat gcttgtgtag ttataatttg gttactcttg atttcacctt 250680 aggaaaaaca atatcacctt ctaaccattt cttttttagt caaatctctt gcttctattt 250740 ctctctgtag atccgctatt aaagactgta atcactgctg catctttcct gtaaggcttg 250800 atcgcattgt taatttcttt ctaaacttgt agagtaggtg tataaatcgt atttgggtaa 250860 tacactgact aatactgaag aaccaggcat tttcttaccc cagtcctcac acgaagtagg 250920 gaaatacaag tcagaactta tcttctcaaa actctgacct cagaatttcc tgagaaatct 250980 gaacctaaaa agattctttg cttttgacat tttttctctg gtgtccaccg caaggctctt 251040 gctcttacat tttttttttt tttctaatgt ttcaaataga agatggtaga gtcatatagt 251100 acaagctcag catcggaggg gctactggag gtcaactagt gcaaatgctt tctgaataat 251160 ggaatccttt gggaataccc ccttgaaagt cttcatctag cctcttcttg gaaaccctca 251220 gtgatacccc tcatcgtctc ctatgatggc agcttctatc tttgtcgtca gctctgacta 251280 ttacaaactg cttccttaca ttgagctgta actaactaaa aagtttccac accctgcttc 251340 tattttagcc tttgggctca taaagaacaa gttgaacccg tcttatgcag aacaacccat 251400 ctacgggaga tgctcaggtt tcctccatgt tttcctttct ctaggctaac ccttcgttgt 251460 tcctcactta ctcactatat aacctgattt catgtctcct tacccttctt gttactctaa 251520 cttgagtagg ctagtttcag gatccagcaa taagtgtgat acatcaggta tgctctgatg 251580 agttgagagt agagtggaca tagcatctcc cttaattcag atattgtgat ctaattggca 251640 aatctggcaa taaaagttga aatgcctgat ccaggacaat ggctggtcag gtgccattgt 251700 tctcatcttt tacttttagg tgtccctcaa tttgttaagt tagtacctac gtaatgtcct 251760 gaaacttgtt aagtttgtac ctacataatg gattaaattc aaaatctctg tttaactgaa 251820 aacaaaagca aacttctttt cagagccaga atctggaatc atacgtaaca gagaatgata 251880 ttgtacaagt tgcttcatct ctttaagtaa cggtttctca aacttacaag attattgtga 251940 gaactaaatt agttctaaag tgcttccatg taaagtgtat gtaaatgctt aaaatatata 252000 gtaagtgctg aatgcatatt agaaataata ataatcttta ttataatttt tactatttca 252060 tgagaagtac ttattttaat actgagcaaa taggaagagt tcatggcttc tctatgtttt 252120 tgaagtgtca tttaatatat tatatatata aaacatatat atatttcagt cacacatttg 252180 tccaaatacc ttgacaaatt aaaacaaaat aagacaaaat tctcacgcta gttatttgtt 252240 ataaagtaat agaacaagtg atatgttata aagagcattt atttctcatg tctttgatat 252300 taaaaatagt tgtattaact ttttatcaaa acgattgctt ccttcatata aatctaagaa 252360 ttatgctgtc tgataaatat tggagagatt aacttctttg aaaatataga agctttttgt 252420 ctttttaaaa tagttgtttt tttgcagatg ttaatacatt tcagcagtac agtatggcct 252480 ttttcaggtt aaggtgctga gcccaaacct caaagaatca ctgcaaaaag attggatccc 252540 ccctcttcac cccatttcgt aatttagtta gtgagaacca caactggcta aacctttgtg 252600 gggggccggg cactgtggct catgcctata atcccagcac tttgggaggc cgaggcaggc 252660 agatcacaag gtcaggaaat cgagaccatc ctggctaaca cggcgaaacc ccgtctctac 252720 taaaaataca aaaaattagc cgggcatggt ggcaggtgcc tgtagtccca gctactcagg 252780 aggctgaggc aggagaatgg cgtgaacctg ggaggcgggg cttgcagtgg gccgagatcc 252840 cgccactgca ctccagcctg ggtgacacag cgagactcca tcttaaaaaa aaaacaaaaa 252900 aaaacaaaaa caaaaaaaaa accacctttg gggggaaatt atcaaataaa acaaactctt 252960 tttagaattt tacaactttt atgttaggaa aaaacaaata catttgtgaa aagcttaaaa 253020 tccagtaaat gacttgaggg acttggggca atcctagggt gatgaggagc aggttagtaa 253080 cagtgaagga cttagcaccc cagggggcca gaggctgtaa tataccttat gagcaagtca 253140 ttcttattta gtcttgccca ttaagaagtc tacttggact aaatgctttt aaaaatgccc 253200 ttttaattta ctattaaaag aatattccta gcagaagtag tcttggatgc taaattctat 253260 tttaagaata actaaaatta gaattctgtt ctttttataa cacctgttac acacacaccc 253320 ctacctagtg tgtcggaatc agtttgtatg ggctcaccaa agcctactgt tcaattttca 253380 ggagttttgt aagccatttg atgtcagaca agtggcctga agtttgttat ggtggtggta 253440 tttacaccat gaaaattggc atgttatggt ggtagtattt acaccatgaa aactgctaca 253500 aatagaaatc tttttcttct tctcttggag agccacttgt tgaacactta ccagctcacc 253560 tgtgcttgaa agtatttctt caaataaaat gaaagctggt tagctttgaa aattttttgt 253620 ataaaagttt acacgggaaa aaaataaact aatttttttt tccacctgtg ttttcaggga 253680 tacgaaaaga ccgaagagga gggagaatgt tgaaacacaa gcgccagaga gatgatgggg 253740 agggcagggg tgaagtgggg tctgctggag acatgagagc tgccaacctt tggccaagcc 253800 cgctcatgat caaacgctct aagaagaaca gcctggcctt gtccctgacg gccgaccaga 253860 tggtcagtgc cttgttggat gctgagcccc cgatactcta ttccgagtat gatcctacca 253920 gacccttcag tgaagcttcg atgatgggct tactgaccaa cctggcagac agggagctgg 253980 ttcacatgat caactgggcg aagagggtgc caggtaagaa tgcgaagcgc agcttttaag 254040 agtcaatagc ttttcaagaa cttgttgtga tgtcatggga gaaatagtgg gggaaaaaga 254100 agcaataaca tgttatgtaa ttggtttcaa ggttacagga gatgtgttca ttttcagtat 254160 caatacactg taattttcca ggagattagg aaataatatt tttaaatcag aatctagaag 254220 actgaaattc ttaaattgac ataatttatt tttaacccat ctcatttacc aaaaagattt 254280 agggtggaca ctacatggta aaactattta atagtgtatg ttcacagtag cagaaacttt 254340 taacactaaa tgaactacaa aagtttgtaa tattaatgac ctttgttgaa aacatctcaa 254400 ttattaatca aacgatttta tcttaaaaag atttttaaga ttcggtgtgg tggctcgtgc 254460 ctgtaatcct agcacttttt ggggctgagg tgggaggatt gcttgagccc aggagcttga 254520 ggccatccgg ggcaacgtgg cgaaaccctg tctctacaac aaatttttaa aaattagctg 254580 gatgcagtgg cacacacctg tggtcccagt tatgggggag gccgaggtga gaggatggct 254640 tgagtccagg aggtcaaagc tacagtgaac catgtttgtg tggagtgcca ctgcactcca 254700 gcccaggtga cagagcaaga ccgtgtcata aaaaataaac cacacaaaaa aagagaaaga 254760 tctttatgga ttaaaaagat aataataagt gtatttactg aatgccaatt atttatccaa 254820 cctggtgtat gcttagtgtt ttaggagaaa gagaaaggca atggaaaaat aaattaaggt 254880 atcatccctg aaagaaactt ttagaaagac acagtggctg aagtgatacc ttgttccttc 254940 agttgattct ctcagaactg gtgttctggt aaaattggac tgttactcct gttattcagg 255000 gagaagaact caagtttgta tggcaacaag actagaaaat gactttctcc ctgccccagt 255060 gtattcgttc aggagctaat gtagataaac cgaggcaaga agaagctaaa ttttttttct 255120 gggcttatag gttaaatgag tgatagattt agttggaggt tttctcattt ggtttctttt 255180 aatagatgaa attaattgtt tcctatgaag catgaaatgt tttatatgaa actaaaaaaa 255240 tgtggagttt gtacttgcat ttcaagggtc actgctctgt tataggccaa gtgaacttat 255300 gtctggcctt agagaatctt acatgtattt gcatctatca gtatataaac atgtgggccg 255360 tagaataagg agccagcagt accagaaccc agccttgtta gaggccacca ttttggtggt 255420 tgagtggtta ttagtttaca tggaagcatg gagaataata ggcaaatgta ggttttcagt 255480 gtcagtcgaa ctggcaaaca aaaatttctg gtcatcttca gaatgaaaag ttttcttgag 255540 tacctacata ttttagcatt ttcatatgaa gcagatacat tataagttaa ttgttggaat 255600 ctaattgtaa tatggctgta agttttttct ttatatttgt tattgccttg ttcttatatt 255660 atagggaaag agaaacaaac aaacaagcaa agaaactaat ggtcatatat ttgagagcca 255720 actcttggtt gctgttcagt tttattttcc tgtaaacata tattttccct tatgaaatct 255780 tgggaatatt agctctggag cactgctgaa ctcaagtaca gacattttca tgtgtatcag 255840 tagattccca tcatgacatt tttataataa tgttgaagag cattttaaac aactggaatt 255900 aagctcaaat acattaccag tggttgaaga attcacatca ataatcttct gaatttagga 255960 ataaaatgga gaagtcaagg aaaggaaaat attatacaca ggctagcaat agttaaaata 256020 caattattaa agccagagct agacaaaatt atggcaatga gatgtgtaac aaaaccactc 256080 tgtaacttca tcatgttcgt ttaaaagacc tgaatgattc caaaatcctt agaccaataa 256140 actatgtctt cttacttgat aattaaaaaa aagaattata aaggcaaaaa tgaaattata 256200 tgtatgtgtg tttgtgtgtg ttccatggga atacagctgt tgtaaatcaa aggcctactt 256260 gcctgaccaa gcagaataaa aatagtcatt gattttaaag agactaaaag tgagggaaga 256320 aaaaagtctt ctgcaaaagc tctacagatg gttgtcaaac ttttcagaaa aatagacaaa 256380 gcaacatttt gaaaaggatt tatatctttt atatattcaa ataccatctg ttatttaaaa 256440 aacatagccc acactgaata tctgatatag acaatataac gtttatgaga taatagtttg 256500 agaatgacaa taataatagt aagttttaaa agaggaaata agccgggcac agtggctcat 256560 gcctgtaatc ccagcacttt gggaggccga ggcgggtgga tcacctgagg tcaggagttc 256620 aagaccagcc tggccaacat gacaaaaccc tgtctctaca aaacagtaca aaaattagcc 256680 aggcttggtg gcacacatcc atagtcccag gtacttggga tgttgaggtg ggagaattgc 256740 ttgaacctgg gaggcagaga ctgcagtgag ccgagacccc acaactgcac tccggcctgg 256800 gcaacaatga gactctgtct ctaaataaat aaataaagaa ggaaatagta aatgtcatta 256860 gtaagaagaa tagcaaaatt tcagttctag aaatacccag aattagctat atgatacaaa 256920 aaccctcatg aaacatttgg ataatcctca gaatacctat caatataaca aaaactatga 256980 attgacttca ttttgaatga tgaattttta acaaaaatag tcaatacttt gggcttagta 257040 gctctagaag tgcttctttc ttctttcttt taattaacag aatattgtca gaattttcaa 257100 atgttgatga ttataagttg aattttcctt ttcattaacc cctggggctt attttttgac 257160 ttgatatgtt tctctactca gaattaagat gtgaagagct ttgggataga atgcatcata 257220 caagtgtgag agtcaagttc caatccataa agtacttctg gtagacctgg ataaagatga 257280 ccttaagaaa tgattttttt tctctttgca gtttaaaaac aacagtagca acaagaatga 257340 taaaacctat gaagccagct ctgacaaaag atgttttttt tataacacat actatgtatc 257400 tactttttga tatttatcta tcgagaagac ttttctcctt attgtttgct ctgaaatttg 257460 tttatattta ataggaattt tatagcctta tccctgggta gaaattcagt ttttttaaaa 257520 gtagataatt aaatcttaat ttactattat tttacacatg gtgaaactag tcaataaatg 257580 taatatcatt gagctgaagg ttaaaaagga aaaaatatga ctgcaagagt ggttgtattt 257640 ttgatttcag catcacactc aattgcatca ttgagtggtt cattcttagt ttcagtgtta 257700 atgaaataca tctgagtttt tttccccaga agcttgaatt gtgtcaccaa agtgtcattt 257760 tgatttattg aaagttaagc cctttccaaa attcaccata attttacatg tctcgaaagc 257820 aattttatac ttcaagtctg tgctatagtt ctatatattt tatgaagatt tggatagata 257880 tctagccctg agttttttat tgcctgttaa atacttataa cccaaagtgt agcagcctca 257940 tgaactgctg ctgggcacag atctgggaga gtgcactcag agtgttggcc caggaagagg 258000 aaaagaggaa aaggggcagt tcagtggcag cttggcttcc tgtgaaacat gtcaccttaa 258060 ccacttcctc attcttttag tggcaaacta gacgaccttc tccttcccct ttcctgccga 258120 gtccccctct aatcaacact ctagaaggcc cctcttcctc ctcagtcctg actccctgtc 258180 atttacttca ggttgcctcc ttgctcagtt ttggccccag gggtaggcaa tctcctcttt 258240 ctggacatgt ctcccaccag ccccaagttc agatttcttg gaagtttctg tgttgtctcg 258300 aggatgcatg gttgtgtgag ttattccagg gctcaaggcc tcttctgtgt ctgtattccc 258360 caggaatcca ggaattcact tctctgcctc tcatcctcat cctcatcatt aaaatgagca 258420 gatttgagct caggaagtgc ttgaataaat gaataaatga acaaatgaaa ggtgattttt 258480 gaaagtctta attttaagaa gtctctgagc cctgttacag ctcaattttc ccataaacta 258540 gaactgctct ctaaggctgt gacatttctc ctttttcctc tcctcaaaat ctacctgctg 258600 ttctgatatc tccctgacag ccaccatagt gagattctat ttccatttcc aatctctctt 258660 ttgtaaggga cagagaaaca gctagagaaa tatggagcca tgcgctctga ggactttagc 258720 aggcttcaac tctatctgca agtgagtttc acttagcgaa tgaaattgga aacttaaagt 258780 gggtagggat gagggttccc ggagaaggtg taatacctca gtctgggaat tgggagcatc 258840 tacaaggaac acactcaatt ctgggaggtt cctgtagatt tcagagattt agcagggctt 258900 cccagcactc tgcttcccaa cctgtcattg gaccagtaaa ccctgctctc aaactgttgt 258960 ggtgtccagc atgctttggc aaggtaatga aagataacat gacatggaca tatgggtgac 259020 atcctggaga gatgacagaa gcctctgttt aaggacaaga tttgccattt agattttgca 259080 cccactgtat aataagagcc ttaggattgg gctggaatcg ccctagcagg catgatggca 259140 gcccctctgg actggcaata tgcagctttt ttgcaagtgt tccatgtcca agtcacccca 259200 cccagctttc tactgctccc gtggaagctc tggtgaaacg caaggaaagc agctgctgtt 259260 gactggattt ttctttcaca tgaaactttg aagcctcata gatgcttatt ggcctggatg 259320 ctattaaacc tttaaaaatc cctttctcat cttgagagta tttgagaaac atgtctgggg 259380 cattttgccc accctcctcc aggttctgtg tcagtgagtg atatggtttg cctgtgtccc 259440 cacccaaatt tcatcttgaa ttcccatctg ttgtaggaga gacccatggc aggtagttga 259500 atcatgggag caggtctttc ccatgttcct gtgatagtga gtaagtctca agagatctga 259560 tggtgttaaa aaggggagtt tttctgcaca agctcttctt ctcttgtctg ccaccatgtg 259620 agatgtgcct tccaccttct gccatgattg tgaggcctcc ccagccacaa tggaactgta 259680 agtccattaa gcctctttct tttgtaaatt gcctactctg ggatgtgtct ttatgagcag 259740 tgtgaaaaca gactaataca gtgagtctgg gtcagtgtgt gtttatgttg aacgtagtgg 259800 acttgtggtg tccccagggc accctgtggg gaatgttggc ctgtggcttt gctacttcca 259860 gggggatttg gcatggagaa tgtgtgtttt aagtaataga tagattatga ttgaagtgtg 259920 ttatgggctg agttgtctct cctcaaaaag acatgttaaa gtcctaaccc ccagtatctc 259980 agaatctgac cttctttgga aatagtgcct ttatataggt aatcaacttc aagtgaagtc 260040 attagcacaa gccctaatcc aataaggact ggcattctaa tgaaagggga aatttagaca 260100 tagaaacaga catgcacaga agaagatgat atgaagagac acaggaagag gacggtcatg 260160 tgactggagt gctgggtctg caagctgaga aatgccaagg tttactggct aacatcggaa 260220 actagaaggg gcaagagtgg actctccccc tcagagagag tatggccttg atttcagact 260280 tctagcctcc agaactgtga ggcgtacatt tctgttgttt ttgaagccac ctagtttttg 260340 atactttgta tgggagccct aggaaattaa tacaaagtgt attaaaaata gaattttctt 260400 ctattgtatt tttgaggcaa aagaaataag gagctattga tttaaggagg aaggtttggc 260460 tcatctagta tagacttggc taatcattta ctcttgtata tttctcttct gcctgcccaa 260520 gtagttcact gaacaggctt agaagttgat ttataattgt aagagtttac acatcagaag 260580 ttaatttata attgttaaca gtttcatgca tctacctcat aaataccttg taaaagattt 260640 tacccttcag aataatgttt tcctctggta ctttagtagt ttatcctttt tttgcatctt 260700 tgatgcattt gaattcatcc tggtatgctg tgtgagctgg ggctccaatg tcgttttcct 260760 acagatggct ccacagttgt ttcggtttca ttcgaacagc ctcctacaga agtatttttc 260820 agacttcttt tatacttgac ttccaagttt actactggtt aagagctttt aaagtagggg 260880 gaaagatatg acccattggc ctactcgttt gattattttt tccaattctg aaatcaaaaa 260940 ttaaaaaatt tattcaaagt tatagtttca cttaatttat attaactgca tagatagtgt 261000 gattcatctg tcctgcttgg acatatttag taacttttaa ttaatcttag agataaaaga 261060 tagaaatcta tgagacttga gacattcaaa taagaccagt actgataaga ggtaatcagg 261120 tgaagtgcca tttggttgta ataggacatc aaaattgttc cccaagagtg aaggatgttc 261180 cattctcact tttcccatct gtcctcccaa attctttcac tcttcctgat gctttgaacc 261240 aacttgaaaa gttagtccac tcagaacctc agctgttaaa cttttagcct ctgcaaacaa 261300 actagccgtt ttcctctttg tccctttacc atcaagctca gttgcttctc ctactcctct 261360 cccttctgcc aggggctcca cccttgttcc tcattcaaca gtggaatcat ctgtgtgcct 261420 gtctcctctt tactgtgtac cattgggtcc tcttcttcac catctctaaa tttatgcttc 261480 ttccctgttc cactgtcacc agcttggtct acatcctact ttgatcattt ggatttaggt 261540 cccaccctaa tcgagtatga cttcatctta acttgattgc atctgcaaag acctgatttc 261600 caaatacgac cacaagtaaa ggttcaggtg gacatgaata ttaggagaga cagcacttca 261660 attaacagtt tggcattagg actttattat ctagcttagt aattgtttta acagataaat 261720 aatagtatcc cctaaagttt aaaatgcaga accagattat gcctcagggt gcctaacctg 261780 agaggaagag tctttcttca acagactctg ggaaagacct ttgtaaaaag gctggtgacc 261840 attctatttg atttctactt tccaatatta actgcttaag tcagacaatc tccttggccc 261900 acgctttccc ctgccattct ccccttcaca taatgtcttc attttatttt tcccttgttt 261960 tattccctga actcccttct ctctattcag attccctgcc cattttttct cctaatgaga 262020 cgcctgactt cctacctcct ttttgaaact tcaaactgct tagcaaatac aattttgaat 262080 tgagtttgct gtcacagaac aaaaactagt ccttggtcca gagtatcttg caggactgaa 262140 tcaactgtgg tctaagacac aataataact cttaattatt ttcttgtttc cttcatggta 262200 tatttgttgc tggatgatga gtttatatta tggttgaatt tcctttttga aatgaaaaga 262260 tgaatagtct ttattggctg ggtatctatt tttatccaga agactttgca aatgagaaat 262320 atttctacaa tctgagttta atttgcttaa gcaatgaact tgttctttaa aagtcgtata 262380 tgtgcaaaat aaatttaaat taaataaatc atattttaat gtagtcaggg tagctttcat 262440 ttaaataaaa cctatgacaa atatccacgt gaagttatca ctcctttaac aaaacaagtg 262500 ttctcctttt ttattgaaat actagttttc acaaattgag attccttaat gtgatgaccg 262560 cttggactga ctatagtata gctgcgttct tagaatggcc ctgaaaccac aaggcctctc 262620 caagatgcat gtggctgact ttctgaggtg actgcattga atctttctgg cttagcttat 262680 tctgcatcca gatccctgga agctatttat ccccaaacag tggtatattt agacccattg 262740 tgtgctaacc tctctgtgcc ctaagtacca acatagccaa gccaaagttc gaactttgct 262800 gccttacaat ggaggttaca tcgtagtgat gaaagaggtt aattttcttt aggagttgaa 262860 gaccagagaa ctgcaaaaag gggagaaaat cagtgtggcc tctaatgaga gctaagtgag 262920 tgaggcaata gaaaacagtg aggaccggcc agtgcggtgg ctcatgcctg taatcccaat 262980 actttggaag gctgaggtgg gcggatcacg aggtcaagag atcaagatca tcctggccaa 263040 catggtgaaa ccctgtctct actaaaaata caaaaattag ctgggtgtgg tggtgggtac 263100 ctgtagtccc agctactcgg gaggctgagc ggggagaatc gcttgaaccc gggaggcaga 263160 ggttgcagtg agtcgagatt gcgccactgc actccagccg gagtgagact ccgtctaaaa 263220 aaaaaaaaga atacagtgag gaccttggag ggaatcttac agtggagcag aattaaaaga 263280 gaagaattca cctatttcct atataactcc ctctgtaacc gataactttc tagagaaagc 263340 tcactgaata tatttgaaat ttgtttcata ccacttttat gttattgcct tctttcacag 263400 gaaccagaga gctctaacct gtagatttgc tttgttgtct ttactttaga ctacagccta 263460 aactgactgt tgatttttgg cacaattatt acatctctcc tttcaccccg cctctagccc 263520 tttcttaatt acccccatta ggcatttttc ttgctagcgt gaactaaatc ccctgtctca 263580 agcacgcgcc tgtacattga aatagaatgt taattcattg acgaaattaa ctgttcttga 263640 ttgggaaccc ctagttccag ggaatcttaa ggtttcaatt ctgttgcctt ggttactaaa 263700 ctgttccatg cagtttgctc aactttgaat ggatacttct cttaggaaca ttctcccttg 263760 taagtaaatt gcttgacgtg ttaaaatcta agttctgttt tacaattctt gagacaaatt 263820 caccatgatt tagttttaaa aacaagtggc cttgtccttt tagtctagga tttatcactt 263880 agctgtatct agcaaagccc ctcacacaat agtaggaaaa agcagaagtg tgattgctaa 263940 atgaagggga aatgtaataa aatgatggaa gtgccctttt ttagggggaa ttaaagtttc 264000 tctttgtagt gttacatgta ttcattatgt gactttcata aatacaaacc ccaataaaac 264060 ggtgggcagt tccgtctctg gagatgttaa gtgtctcttc atagaataac atggcacatc 264120 ataacatttg attcctttta cctggtcaag atgtttgctt atggcatttg aaatgcatat 264180 tttcaaacta ggtagatgaa tggtttaaat ataaaaattc attcaaggcc ctgagctata 264240 gaagaatatc ttccaaaaca tgcattcaag ttctatctgt cagtgttttt ctttttgcat 264300 caataaggca gcaatggaat acaatcagat ttattttttc tttattgctg tctacaattc 264360 agagatataa cctgaaaaat atgttgtctc ttcccaagta gatcttgtaa ttctctgaac 264420 tgtgatccag accaatgccg cctttacatt gggtctgtgg aagtgggagg gtccactgaa 264480 cctggttatg agaggtttca aattgaaaag atttacaagt atgtaaataa aatcaaatag 264540 tcaattagta tctaacatat acatgtcaaa acacatagcc ccaatctcat aaaatcaaag 264600 agatctacct aaatagattt gtttgcctaa caaatagcaa gaccactttg acagaatctt 264660 tagcatgaca gtgattgtca aaatgggtaa atggttatta ttgcccagtt aagtaatttc 264720 tgatttgctt tgccttgatt actcttaata aactaaactt aacataccat agaagcaata 264780 ttttttaaaa agagggtata ttctagagct agatagggtg ttgtgcaaca atgtgaatgt 264840 acttactacc attaaactgc atacataaaa agggttgaaa tggtaaattt tatgttatat 264900 acattttacc aaaataaaga aaagttataa tactttccgt agcatatata aaaaagaaac 264960 agacatttca tagcaaaaat aggataaaaa tgatattaaa ttcatagggg atttctctta 265020 tctaaaactt tagatttgat tcttagataa gaatataaac acattgcaag aagataaatc 265080 aataagccaa tgaagtaagg tggaataaat aaatagaaat aggtgatact tgcggctctg 265140 acagcatctg ataataatag tacaaacagt ttcatttcat ttaacagtta tttgatgaac 265200 tcctgtgtgc taggaactgt tatttaaaaa aagtaacttt tattttaggt tcaggggtac 265260 atgtgcaagt ttgttatata ggtaaactca tggctcgggg cttggtacac agattatttt 265320 gtcacccagg tactaagcat agtacccaac agtatttttt tttccgaacc tctcctcctc 265380 tcaccctccc tcacgtaggc ccagtgtctg ttgctcccct ctttttgtcc atgtgttctc 265440 attatttagc tcctacttat aagtgagaat atgcattatc aggttttctg cttctgtgtc 265500 agtttgctaa ggataatggt ctccaattcc atccatgttc ctgaaaagga catgatctct 265560 ttctttgttt ttatggctgc agtgtattcc atggtgtata tgtaccacat tttcttcatc 265620 cagtctacca ttggtggaca tttaggttga ttccatgtct ttactattgt gaatagtgct 265680 gtaatgaaca tacgcgttca tgtgtcttta tggtagaacg atatataatc ctttgagtat 265740 atacccagta gtgggattcc ttggttgaat ggtagttctg tttttagttc ttttagttct 265800 gtgtgtgaaa acacaccaga gaacaaaatt gaccagatct ctgccttcac agaacgttca 265860 ttctactgta ccagttattt catgaggaat atgaatactg ttattactct ctgcccattt 265920 cacacatgaa ggagcagaaa tggagcagag tttactaatt tatctgttgc agatagtagc 265980 taattgtgtg ccaggtgctg ttccaagcat tttacccctg ttaactcagc tgagtgcttt 266040 tattttcccc attgtatgcc caacttatgg atgacagcac tgaggtagag aaaggttaat 266100 aacatagaat agtttagtat tagggaaaca atttgaattc taggacactt ttactgaaac 266160 ttagcatagg ctaaagaagt gatcgtgcat gtttaaagag ttgtatcatt ttatcattat 266220 ttgactttct tttccaaaaa aaacaaccct tctcctttct ctctcttcca tgtgacaaat 266280 acatgtctgt atacatacat atatatgtaa atataaatat atataaaaat atatataaat 266340 ataaataaat atatatatat atatataaat atatatatat atataaaatt tttttttttg 266400 agatggagtc tcactctgtt gcccaggctg gagtgcagtg gcatgatctc ggctcactgt 266460 aagctccgcc tcctgggttc atgccattct tctgcctcag cctcccgagt agctgggact 266520 acaggtgccc gccaccacgc ccggctaatt ttttgtattt tttagtagag atgggctttc 266580 actgtgttag ccaggatggt ctcgatctcc tgacctcgtg atccgcccac ctcggcctcc 266640 caaagtgctg ggattacagg tgtgaaccac cacgtgcgac ccacatgtct gtatattaca 266700 gccgttgaag gacacaactt ttgccattgg gcgacccagt cccctagtaa gtgttcaaaa 266760 atattcgcta ttatcattgt tggtgatttc gaggatttgg atataattaa tttgagccta 266820 attttttaag actattacat aactatacaa aaaaatcatg agagagcctg gaattttgca 266880 aaactaggat agaaaccagt ttctaaaaag cattttaaac attcagcttg tgtatttctt 266940 ttcacttgta ttttgtgatc tgcctccatg ctttcatgcc tttctcttca aacaatctta 267000 ttaccactaa ccaaaaacaa ttaaaatttg attgttttgt ttttacatgt tgttacagtt 267060 aagaaaaaaa aattctaggt attgacccct gccagttttc ggagttaata ctaactagtg 267120 atttggggct acatttaagt gctttaagct atcctacaag cttaaagtag ttatacatgc 267180 aaatacttaa atgaattagg tacaagaata cagaggtaag aaatagaatc tattgtagaa 267240 taaatcctat ttcagatgtg actgttttag gatttgaatc aaccacatat tacagaaaac 267300 cccaagataa agccttggca taaccaagac aaagtttatt tttttctctc acataaaatt 267360 agtccagact tattttacca gtggtatggc aactccacag tcaaagggac ccaagctcat 267420 ctgaccttcg attcccttat cctgggacag gcttacattc tcaaggtcga ctcctggcct 267480 aatggggcta ctggagcttc agccatcaca ctctgtgctt cctgttatat ctactggtca 267540 gaacttcaga tacatctgtc taaaaggaac gctgaaaata cagtctttaa gctgtgcaat 267600 tgtacctgga ataaatgagt tcttttaata aaaagagttg aatggatatt tggtgggcaa 267660 atagcagtcc atgctacaat aataaacttc acaattttag aattagatat cttgtaatga 267720 atattctgac gtggtgtcaa cttataccat agatagatta taactttgaa aaggaattag 267780 aacacaataa taataaattc acactaaggc tcttttgggg aaaaaaaatc tctaccattt 267840 attgagtgtt tattatcttc acaacatccc tatgagttag ggattatttt tgtggacatt 267900 ttacagataa agaaacagag gcattgagat gataactagc ttgactaagg agtggcggag 267960 ctctgggcag tgtggttcct gtgtgcccat aaggccattg cacaatgctg cttcatcatg 268020 taattcagaa agtattgcag gatgtggcag ttggtcatca tgaatgttca ttgttatctt 268080 gtggctttgt gaaaaattct ggtcattcaa acgatttgac tgttgagatt ctgtgcacat 268140 gagattgtac tgtgtacatg tttctaaaaa tgtgtgttat agatcaaaat gcacacactc 268200 atttacctct aagaacagtt cttatattga agggaaatta tctgtacgtg agagaacaac 268260 gtggttttga gtacaagtgg tgaacagaca ttgaatagtt gttttcagaa agcatcactc 268320 ccctgtacct cagaacccag cctcagtgct ggttgcgagc caacagcttt gatgtcctga 268380 agtttttgca tcacttctct tttgcccctc tttgggattc aaagatgata agtttgaagt 268440 ggagttctac cgcttccatt ggaagagaaa aagtttccgt gtgtgtgtgt gtgtgtgtgc 268500 gtgtgtgtgt ttacggagag gagttctatg catctgcaga gggtgctgcc atcaacaagg 268560 agaacagagt gggatgaagg gtttgggaag ccaggatggg catctctgac gagctccaga 268620 actctccacc taagtgtgca agtgtaaaca ctccctgatg tgtgaactgg ccatctcaag 268680 actaagtatt tagcaggaaa tgccccctat tcaacccttg ccttctcagg tgtagaggtt 268740 gggttgtctc ttccatcttt gtttgaatta tgtcattaat caaccttagt gaaagatcac 268800 ttagtcattt gtgacagcat aagttcttaa ttgttaggaa tcactggtgc ggcacacatc 268860 tttttctatc catgaacaac gtcaaatgct tattttctca tgagctttta ttttttcctt 268920 ttaaaaaaag tttcttagga taaacacagc ctttttcctt gtctctccct tgccctctca 268980 tctttttctc aatctttata ttcctatatg tcactgaaga gtccccgtgc caacgctgtg 269040 cagtgggagg ctcctacctc caccagcttt tgaggaggtt gtagtcctgc aaccttagag 269100 gttccacagc caagctgggg gtctttctgg agcatgggtg gtgaatctga gatctatgca 269160 cccaggaagc ctgacacatt attgtggtgt ctcaattctt ttttttttaa ttagaaaaat 269220 tgtatcaaat tgcatttggt gagagcaaaa ataaactgaa gttggttgag ctttggaaga 269280 ctacaagcca ctgtaatatt taagatttct tgacctccag aactaacatt tgtcctgtca 269340 gagaaaataa ttactcctgt tgagaataca tgcattaaag taagatgttc actactctat 269400 atgatcacca aacattaaat aatatgtttt acacatgtat gtactatgtg ttcaagtgtt 269460 tataaatcca tggagccaat agaatgtaag ttctatgagg gcagaaattt taatccattt 269520 tgttcctaga acagttcctg acacatactg gtgttagggg taggtcttca gattttatgg 269580 atcaaatgga atctccacac ttaaaaaaac ttagagaaaa actgccttaa tgtgcccata 269640 gtctggttgg aaatggcagc tccaggttca ttgattgctt tgttcattcg gcacttttca 269700 ctggacatgc tatgagccca gcagtgttct gggtttttgg gatacaccaa gccctgcctc 269760 cccggtgctt aacattctag tgggggagac agaaagaaag caaacatggt ggacaactta 269820 attatctatt tttgaaagtt gacaggaact gtggacaaaa gaaaacaaga gctggagaca 269880 gcagtgccag ggcagggtga gggtcaagtt agagtaagcc tcattgagag atcttttgag 269940 caacacctga aggaggaggt gagaaagtta gccatgtgga gggagcagca ttccaggcaa 270000 gtggcccacc aagtgcagag tcctgacagc aagagcagtt ctggaatatt ctagaaacag 270060 gaagaagacc aatgtgacta gagcagagtg aggcaggagt gagagaaaat gtgatcagga 270120 aagtaaggtc ctgtggccac taagattttg gcttttattc tgaaggaaat gaggactcat 270180 tgcaggactt tgagagcatg atctgacttg tcacaagtgt tctctttgtc tactgggttg 270240 agaagacatc caaagggggc caaagattga ggcagggaga gcagctagga caggctctag 270300 caatctaggt gataaatgag gaccgatggt ggctctgaca agggtggtaa tggagacatg 270360 gtgaggagtg accacatttc aaatatatct tgaggtagag ctgacaggat tttcccgatg 270420 ggctgggcgt agtatgtgag agaaagaatt cagttatgga tgattatttt gtcctgaaca 270480 atgataaaag ttgagtcaac aactgatatg gggaagtcta caggtggaac aagtttttga 270540 ggaggaaatc agttcagtgt tggctatgtt gaatttgaga tgtttttaga ccatctgagt 270600 ggagaaatct ggagtttagg agagaggctg gacttgatat gatgttatgg gtcctcagca 270660 tagagatgat gaatgagatt agcaaagtag tgagtgtaaa aaggaaaggg aaggagacca 270720 aagattgagc cttgggacag tcagaaagaa gagagggaac ccgcaaagga gattgaaatg 270780 gaatccatct cactgtggca tcgtgaaaga caaatgaaga tggtataaga tgaaaaagtg 270840 atcagctgta tcaaatgctg ctattgggtc aagtagggtg agaattgata attttccatc 270900 ttgtcaagag cagccgtgat agagggaggg ggtggagata tacttggaat gagttcatga 270960 aaaaatggga gggaagggat tagaagcagc aagtataagc agctctttca aaggagggag 271020 atggggaatg gctactggga tgccatcaca tagataggaa ggtggaaccc tgtgcactgg 271080 aggagggagt gtcctcacag aggaggacag gcaggaaggt agagtgggct gctttgggca 271140 catgtggttc tgtggatgtt ctcttttgac agcttcagtt cttcagggaa ttgggagcaa 271200 gttcatcagc tgagagtgaa catggggcag acagtgtgag aggtcaaagc ggcaagagta 271260 gttgtgccac agtcttttag gagagaggga aagtaaatgg aatggggaag gaaagtaaat 271320 agcatggctg ctgagctgcg ttacaagccc acccggtgtt gggttgtgag gtgtagttgt 271380 gggctcttct tcagtcggat tgtcagcatg ggcggctggc agagagttga atctgacagg 271440 gcagcagttc tggaaaatga gtatgatgag tcaagaaagg gaccaggaag tggaaactgt 271500 gtgtgaggca gtgatgctga tgaatgactg tggaaaacaa tggaggtgag gagggagtgg 271560 atgttgagtg gctaggggac agtgaaaagg gagtaggatc cactagcttg ctgcttgtct 271620 cttataatta ggatcaagag cttctgccgt cttctaggca ttctgctgct tcaagggagt 271680 ctctgagatt gggttctgca tggatgtatt gaaacatgca cctaggtgtg tttggagtcc 271740 tgccagagac ctgctttctc tttattctta tcctgaggcc ctttaggagg ctcagatgga 271800 ataattttta tggtttctta aaacccaagt gggttaccta agccatcata gttctgcccc 271860 ctgttccctg agaggaccac gggagcaccc tgaaatgggt tttccactct gccatccccc 271920 acttgcctgc ttgggtgttg acctcagcca tctacacata tcccggatgt agtgttgggc 271980 ccctggttga tgtcattcct tttcaaatgg gatcttttac tacagcaatc cagcaacaaa 272040 ctaaatagcg atagagtttt ctttccctta caaaccacaa ccacaaccaa gggaaaaacc 272100 aaaccaaacc aaccaaacaa acaaaacaaa agtatgtggc ttcttaccac agccccctat 272160 ctcgcccaag ccttgtggct ctttgatctc tggtgttctg aaattgcgta atcatgtgct 272220 tgctcttttt cattcattgt gctgggcaca cacttaatgg accctttcaa gttggttttc 272280 ttttatgggg taagggtagg caggactatt ttttaagatt tcttccactt tgtcttccaa 272340 ttgttctaat gagtttttta aaattgtgcc tgtcctgttt ttaaattcca agagatattc 272400 tttgtcctct aaatgtttct tataaatata tataaaatga ataatataag catatagttt 272460 tgcatagatt tgagttcgct gttacagtgt ccttttattt ctctgaggat attcattata 272520 ggttttttaa aaaacacttt ttctggtccc caaattatct cttctctcta gacttcctcc 272580 attcatgcct tccttccccc ctccctccct tcctttgctc ttgctcttga ttttggaggc 272640 ttgtcataaa tatttgacca tccattcatt ttttaaccat aacgaactaa aaatgttaat 272700 tggagccctg tgtgttcctt gagcagaatg tttggattaa tgagcttccg tgcaatgttt 272760 tctctggaat ggattaattt ctccagatct ataatttttc aatctctttc cagggggtaa 272820 aagcctggtt gtctgtttca tgaaagtaaa aatgtgggta agagtgatcc cagcattcag 272880 aatgcagact tagtagctgc ttgttttcag tcctgggact tcacccaccc tcaccacagt 272940 tggtatccca aagtgtgaaa ctccttagat tatctttctc aagaaaatga aactcagata 273000 ttcgtgtcct ttggccattt ttgattagct tatttgtttt cttccttttg aattgtttga 273060 attccttatg tattttgaat attaacccct tattagattt atggtttgca aatattttcc 273120 cccactctgt gggttatctt ttcactttgt caattgttta ctttgctgtg cggaaagctt 273180 tttagtttca tgctatcaaa ctaattttgc ttttgttgcc tgtgcattca aggttgtatc 273240 caaagaactc attgcccaga tcaatgtcat ggagcatttc tcctatgttt tcttctggta 273300 tttatatagt ttcagtgctt ttctttaaat tttaatccat tttgaatgga tttttaatag 273360 ggcataagtg tcacttccat ttttttatat gtggatatcc agttttccca acaccattta 273420 ttaaagaggc tgtcctttcc ctattgtgta ttcttggcac ttttgttgta aataagttga 273480 tcttacttgt gcgggtttat ttctgggcct tctaatctgt tccattaatt catgtgtctg 273540 tttttatgcc agtatcacac tgctttgatt acaatagctt tataatatat cttgaaatca 273600 gagagtttga tgcctctagc tttgttcttt ttgctcaaga ttgttttggt taattggggt 273660 cttttgtggt tccatacaga tttaaagatt attttttcta tttctgtgaa aaatggcatt 273720 ggaaatttga taggaagtgc attgaatctg cagatcactt tggatagcat agattttttt 273780 taacaataat aatttttcca ctccatgaag aggtatactt ttttcattta tttttgtttt 273840 cttctatttc ttttatctgt gttctgtagt ttttagtatt caggtgtttc acctccttgg 273900 ttgaatttac cccaagtatt ttgctgttgt tgctattgta aatggaattg ttttcttaat 273960 ttcctttttg gataattctt tattattata tagaaaagct atggattttt gcatgtttat 274020 tttgtatgct tcaactttac tgcatttgtt tatcaggttt taacagtttt ttgataaaag 274080 ttttggtgtt ttctgtatat atgatgatgt catcagcaaa cagagacaat ttcatttccc 274140 tattttcttt cttttttttt ttttgagatg gagtctcact ctgtcaccca ggttggagtg 274200 cagtggtgcg atctccactc actgcaagct ctgcctcctg ggttcacacc attctcctac 274260 ctcagcctcc cgtgtagctg gggctacagg tgcccgccac cacgcccagc taattttttt 274320 gtatttttag tacagacgga gtttcactgt gttagccagg atggtctcga tctcctgacc 274380 tcgtgatcca cccgcctcag ccttccaaag tgctgggatt acaggcatga gccaccgcgc 274440 ccggccccta ttttcttaat cacgcgatat atacaggctt gttgaaaaac atgaaaatga 274500 taaagaagtt tatgtattaa gaggcaaaag ctatgatgtt caactcctct aaaaccactt 274560 cttagtaggt gaacattgtt aaacagtttt gtgaatctgc ttccagattt tttctaggca 274620 tgttcataca catatacaca cataatttat ttttacccag ttgcgatcat gtatcatctg 274680 atccaaaact cgctattttt cagttaatat gcagtgactg tctttccaaa ccatagtata 274740 tatatatatc tctaagaatt tttcaaatct gctatagttt ttaaacatat ttattgttac 274800 atacatatgt gtataagtta cttatttgct tatttctttg aatatctttg tctagctttg 274860 gaatcacata aataatgagt acaaatggta aagaaatttc atgtggaagg atatatagaa 274920 aaagtacaag tctctcttct catccactct atctcattac ctaaaaggtt atccttagag 274980 ctttatataa tacatccctg aagtttagat cattttattg cctcccaatt gttgagagta 275040 aggaatttag tacatatacc tttcctttca ctttcctacc ctctacctac ttaatgagtt 275100 cgattatagt ttttcagttc acccactgtt aaataatata cctatattta taatatacct 275160 atataatata cctataataa acctatattt ttgacttatc aactttggac atatctattg 275220 gtgacttgtg atgagagatg aaataatttg tacatttacc cttcttttcc attcttttcc 275280 cctacccatt ctcccctttt tggctaaatg attgctttta ggttgataag gtttataata 275340 gctactgttc tgtggttata aaatttgttt catattttat gtgaaatttg attatacaac 275400 tagcattcaa aacattatta tgtaaatatt agttactgta atcacacagt gacgctcaag 275460 gaggtattta ctaagcatac agatcattcc ttctggatcc aactcagcag ttgctttgct 275520 gtgccttacc tcatctttcg tggattcctt ttcttttgat tgcaatatat ccttgagtaa 275580 tttttcagaa tcgatatgta ctgtctgaac tctcttatac ccaaaaaatt tgctttcaca 275640 tttgctaata gtttgacaga gtatcaaatt ctgctttcaa attctttccc cttcatggct 275700 ttgaagatac tgccccacta tatattctaa aatccattgc tgctaatgag aaattctggt 275760 gtcactctga ctcttatttc tttcatatca cttggcattt tcttccgaga aaatattact 275820 tatcttcaga atgatgaacc ttctctatca tgtctctagg tgttagggct tctttcattt 275880 aatcctgtag gtcctcaata ggctttttaa ttaaagtctc attttattcg ggctctgtga 275940 aattttttgt tatgttttgg cttctttttc tcttttgttg tctctctttt ctccttgaat 276000 gtctttctga tagatatagc attcccatta tctatcatgt ctttcagatt atcctacatt 276060 tttctctttg ttttcttttt ctaccatgtt tagaattctc ttacacgtaa gacatcactt 276120 actagatctt cagtcatatc ctttttatta ttcagtctgt gcatttttaa ttttcaattt 276180 tggcaaccac atttttaatt tctaagaatc tattttgcta atagtacttt tgtcctgaaa 276240 ctttttatat cctgcaatat ttagaaagag cacaccctta tccacagctg attaggagta 276300 cactctgaat gcagggcacg atgggcgaac attttgttac tggcctcctc aagcctcaat 276360 gcccagaagt tattgcctcc atcagaaacc cttcttttgt tctatccctc acttccaaat 276420 gaagttccag cttaattttt gctgtcactg tagtgggaca agcaaatccc tatttcacgt 276480 gatcattgct caaacctcta ttgacaatcc tgctttgcat tcccttattt agagtgggat 276540 ggaaaataaa ggctatgaag ggggaagaat ctgatcccac cattctcctt tttcattgca 276600 gttttctcct tttttatgga tgcaataagc tgttgcaatc tctcaggatg gaaaagaaca 276660 ttttaaaact actctactgc cagaatgatc tctttttttt aattatactg taagttctgg 276720 gatacatgtg cagaacatgc aggtttgtta cataggtata tacgtgccat ggtggtttgc 276780 tgcacccacc aacccatcat ttacattagg tatttctcct aaatgctatc cttcgcctag 276840 cccctcaccc cttgacaggt cccagtgtgt gatgtttccc tccctgtgtc catgtgttct 276900 cattattcaa ctccccctta tgagtgagaa catgtggtgt ttggttttct cttcctgagt 276960 tagtttgctg agaatgatgg tttccaactt catccatgtc cctgcaaagg acatgagctc 277020 atcctttttt atagctgcat agtattccat tgtgtatatg tgccacattt tctttatcca 277080 gtctgtcatt gatgggcatt tgggttggtt ccaagtcttt gctattgtga atagtgccac 277140 aataaacata cgtgttcatg tgtctttata gtagaatgat ttataatcct ttgggtatat 277200 acccagtaat gggattgctg ggtcaaatgg tatttctggt tctagatcct tgaagaatca 277260 ccacgctgtc ttccacaatg gttgactaat ttacactccc accaacagtg taaaggcatt 277320 cctatttctc cacatcctct ccagcatctg ttgtttcctg actttttaat gattgccatt 277380 ctaactggca taagatggta tgtcgttctg gttttgattt gcatttctct aatgatcagg 277440 gatgatcagc tttttttcat atgtttgttg gcctcacaaa tgtcttcttt tgagaagtgt 277500 ctgttcatat ccttcgccca ctttttgatg gggttgtttt tttttcttgt aaatttgttt 277560 aagtaccaaa aacagataca tagactgatg gaacagaaca gaggcctcag aaataacacc 277620 acacacctac aaccatctga tctttgacaa accggacaaa aacaagaaat ggggaaagga 277680 ttccctattt aataaatggt gttgggaaaa ctgactagcc atatgcagaa aactgaaact 277740 ggaccccttc cttacacctt acacaaaaat taactcaaga tggattaaag acttaaatgt 277800 aagacctaaa accataaaaa ccctagaaga aaacctaggc agtacaattc aggacacagg 277860 catgggcaaa tacttcatga ctaaaatacc aaaaagcaat ggcaacaaaa gtcaaaattg 277920 acaaatggga tctaattaaa ctaaagagct tttgcacagc aaaagaaacc atcatcaggg 277980 tgaacaggca acctacagaa tgggagaaaa tttttgcaat ctatccgtct gacaaatggc 278040 taatatccag aatgatctct attttatttt ttatgacata ttaatcatgt ttgttctctt 278100 gtgtcctctc tttctttctc tcgattttcc agtggtccat ggtggtctat ttgtagggtt 278160 catatttaca aatgggagtc aaggtgactc cactacagtt atgtgaaaaa gtttccctgc 278220 catgcctctc cctacactgg gcgagctgat ctggttccgg gtcagtggat ggagcatttc 278280 ctctcgcagg cacaccttca ggctggtggg agcaacttgg gccatggact ggaaccatgt 278340 caatggagaa gacttcctct gtgccaggtc ctggtcagag ctgccgtctt gatttatttg 278400 tatccctctt tccgtctgtg gtaaagatct ggaggttctt aagctctctc tggcctcaaa 278460 acccacagca ggaaatttcc tcactcagat cacccacatt tttagcaagc agagcttcag 278520 ttttgagtgg agggcaggag tattgggcag tagggaagga cacagttctc tacgccgttc 278580 tgaatgcagt gcattaataa actctcttca cagttgctcc agggtgcttt gcattggtga 278640 acttctggct tccaggaaga acctggttac ctctgatgtg ttgggttgtt gttccatcta 278700 ctctaaattc tgtgccaatc catcccatct gtttcctacc attggtttat ttttaaaaaa 278760 tattttatat ttatgtagat ttatgaactt gattattata ccatcattag agtttgggtc 278820 cagagtcaaa cttctataaa cctgtaatca aaaattggcc tttattttca tgtagaagga 278880 agtagcagac caaaatggag ttctatattc catttttcta aatgagccat tgagatgtag 278940 agcaagcaag tgcccttttg agggaatgtg tgtgtgtgtg tgcacacatg caagggcatt 279000 ttcccatgtc tcccatcctt taattattcc agtagacagt gggccagcag caggtggtgg 279060 cataacttct ccatttgcag tgctgtggct gtggtgggat ctgaacagga ggcaaccttg 279120 gcaacagtag gaatagaatg tggagtcagc aggaagcgct tttccctccc acttacctgt 279180 cttcttgtag cagacagcag tgcgggcagc ttcggctgac ttgcttagcc tgtttccatt 279240 gtgagcataa acaccttaga cgttttttca tttcaggaca ctggagcttg atgaaattaa 279300 actacactca ttgtctcagg caaatctcct aatcctattc tgtgcttttg ttgttgttgt 279360 tgttgttgtt agtggtgtgt ttctctctcc acttcgcttt ccttttaaaa cacaacaaat 279420 tttttttttt aattttaaat gaacttattc attgcctccc tatgtgtccc ctcctttcta 279480 gtgatattgc cgctgttcat tcccagctgt tcttgattct tgtacaagac tctttgctgg 279540 gcttctgcct tctagacgct tcaccttccc gttatttctt ccctctgccc ccggaaaggc 279600 ccttaccatg gctctgatga tgatgacagc tgaccctttt ccaaggtgga atccacgttt 279660 gattctctga tcttgtactg gcttagcaca gtgctcggca ttcagtaaat aaggttaagg 279720 aaggccagtg atatagagta gtagaaaaca gcagttaatg aaggcttgct ttctgtcaca 279780 ggttcctctc ctccaggact gcagcatctc tgtctttctg tcgtagcata caagacagca 279840 tctctgtctt tctattgcaa cttccaggtg agaagccctc ccacaagcat atacaaattt 279900 tatggaaaca gacaaaaatt tgtagggaag caaatccctt caaggttgag tctttctggt 279960 cttctagaag gtaagcttgg tgatggggca gtcacagccc tagtgcttat ggaacttggc 280020 cctttgggga cagatctcag ttaactaaag aaatgctatg gcacagagta ccttgaatct 280080 cctctaattt atgctgtaca gggaattatt cacactttat tgttaataac acattacatg 280140 ggggaacacc agacagctga ccaggactcc tgtgcttgaa agcttctgct cttcagcagg 280200 gcagccagcc tcttctcggt ttagcacaga gcttttattc tcctcgctct ctctaaactc 280260 ctgttcaaga cagtttccaa ttctgttgaa ttcactcatt tacctcatct gtgcctttcc 280320 ccacctcatt ctctcccctt cagagtgccc atttctgtgt ttcaaatccc acaaggccaa 280380 gcttagatgc tattatgtct atgacattct ccacctctat cccaataaaa acctttgatt 280440 tcatcttgct gtttgtatct ttactctgtt atatttcacc cataccagag ttgtttgtgg 280500 acatgcctga tttccttcag gctgtaggca tatttgattc atttttgtac tccatgagtg 280560 cctaacatag catcttatac accatagata attaatagat gcctcttggc tgcatttgta 280620 ttaaattttt accatgtact tgtcctagct agcagagact tggggggaaa taatgatgac 280680 tgatttttac ttatttattt attttttatt cccacaggtt tttgaggaac aggtgatgtt 280740 tggttacatg aataagttct ttagtggtga tttctgagat tttggtgcat ccatcacacg 280800 agcggtgtac actgtatcta gtttgtaatt tttttatccc tcactccttt ccctcccttt 280860 ctcccgagtc cccaaagtcc attgtatcat tcttatgcct ttacataccc atagcttagc 280920 tcccacttat gagtgagaat atatgatgta tggtttttca ttcccgagtt acttcacttt 280980 gaatagtggt ctccaattcc atccagaacc ctcaaaacca tgcaaaaccg tggaaacaaa 281040 atagcctgct cctgaatgat cattaagtca acaatgaaat caagagagaa atttaaaaat 281100 tctttgagct gaatgataat agcgatacaa cttaccaaaa cctctgggat acagcaaaag 281160 cagtgtcaag aggaaagttc atagcattaa atacctacat caaaaagtct gaaagagcac 281220 aaataggcaa tctaaggtca cacctcagag aactagggaa acaagaacaa atcaaaccca 281280 aacccagcag aaggaaagaa ataacgaaga tcagagcaga actaaatgaa attgaaacaa 281340 acaacaacaa taaaaaagat aaatgaaaca aaaggctgtt tttttgaaaa gataaataaa 281400 atggatataa cactagtgag attaaccagg aagagagagg atccaaataa gctcaattag 281460 aaacgaaaca ggagctatta taatcaatac cacagaaata caaaagatat tggaagctac 281520 tatgaacatc tttacacaca taaactagaa aacttaaagg agatggataa attcctggaa 281580 atatacaacc ctcctaggtt aagccagaaa gaattagaaa ctctaaacag accaatagca 281640 agcagcgaga ttgaaatgat aataaaaaaa attgccaaca aaaaaagtcc aggaccacac 281700 agattcacag ctaaattgta tcagacattc aaagaaaaat tgataccaat cctactgaaa 281760 ctattccaca agacagagaa agagggaatc ctccctaaat cattttatga agccagtatc 281820 accctaatac caaaaccagg aaaggacata acaaaaaaga aaactacagc ccaatatccc 281880 tgataaatat agatgcaaaa atccttaaca aaatactagc taagtgaatc caacagcata 281940 tcagaaagat aatcaactat gatcaggtgg gtttcatacc agggatgcag ggatggttta 282000 acattcacaa gtcaataaat gtgatacacc acatgaatag aattaaaaac aaaaatcaca 282060 tgagcatctc aatagatgca gaaaaagcat ttgacaaaac ctagcatcca attatgacaa 282120 tttttaaata tggggaatgg tcttcatgga aaagtagatg ttaatggcac ctgtattagg 282180 gttctctaga gggacagaac taataggata gatgtatata taaaggggag tttattaaga 282240 agtattgact cacacgatca caaggttggg ttccgcaata ggccgtctgc aagctgaaga 282300 gcaaggaagc cagtccaagt cccaaaacct caaaagcagg gaagccaaaa gtgcagcctt 282360 cagtctgtgg ttgaaggtat aagagtccca aagctgaaga acttcacgtc agaaattcga 282420 gggcaggaag catccagcat gggagaaaga tgtaggccag aagactaaac cagtctagtc 282480 tttccatgtt cttctgcctg cttttattct ggccatgctg gcagctgatt agatggtgcc 282540 cacccagatt gagggcgggt ctgcctttcc cagctcactg actcaaatgt taatctcctt 282600 tggcaacatc ctcacagata cacccaggag caatactttg catccttcaa tccaatcaag 282660 ttgacattac atattaatca tcacagcaac caaaagatta tctcatttaa tccttacaat 282720 agctctgtgt agtgggtata tattttcctt ttgctgaaga ggaagtaggc ttagaggggt 282780 tgagtaattt gcccagaata cctaggtagt agaagatagt agagccatta tattctgtct 282840 gcattcaaga gtgtgctgct ttatttgttc ctgaattgca cacaagctaa agaatacaac 282900 tggatgttca gtctactcct attttgataa cttggctaac tttactgcag agtctgcaga 282960 ggtgaccaat tttactctgg gagataccag ggaatccgcc atgtaattcc tcaggctgag 283020 tgttttggaa acacaaagct gtcactgcta ttaagtgatg ttttttcctg agagtctact 283080 atgctcccag taccagcctc cgcaggccct ctgtctaccc cttttctgtc ctgatgtgtt 283140 ctagcaggca ctgagaaagt cattgtagaa gttaccatga ctttccaaat gcttccagaa 283200 gcagaacaca atttcacagg agggccaata agtatgaatg ccaccttgat agaaagtgaa 283260 gttttgcgtc ctgttgaaca ctcagtaaat gcttcctgaa tagatgcagg attggcaaaa 283320 catagctccc cagctttcat aattcagact cagaggccct tcgtgctcct gttattcttg 283380 ttacttcatg tcaggtacct aaaagggttg tttttcagtt ttcgtcattg atttaaagca 283440 gaggttagta aactttttct gtaaaggcca ggtagttagt attttagcct ttgtgagtat 283500 ttggtctcac aaaagcagcc atagatgata tgtaaatgaa tgtgcatggc tgtgttctga 283560 taaaacttta tttaaaaatg aggggtcatc tgggctgtgg tttttcaacc cctgatttaa 283620 aacaaaaaca aaatgtgcta tgcctgttag atgctactac atttgattct gtgttttcca 283680 tatttttcta aaatgtactg aacaggaaat gaacaaactg atgacacaat gatctaattt 283740 aatcattgag ataagagtgg cgccaactct tattgagtat ttgttatgtg tcaggcactt 283800 ggctaagcac tttacatgtt ttctatgatt tataaagcaa atattgttat tatcttcatt 283860 ttttgctgag ggaaggaata aagtcacagc cagcttacag aggctgccgg aggtcacaca 283920 tcaccagtac actgaaacac gtggtctgat tacaggatcc atgatctcct gtacagatca 283980 tagtgatatt gacctgagag gaaagagcct aggacttaca atcagaaatc tgggttcaca 284040 tttcaactcc gttccatgcc aaattacatt aaaactgggc ctcagctttc ccacctgtga 284100 aagaggaata atactaggac ttgccctccc aaccttagag attgctgtga ggataaaagc 284160 ctatatgaat gtgctttata aactataaac accatacaaa tgtttgttat aagtctgcca 284220 tttgaataca tcttagtctt tttttcctat gtgaaataaa acattttaag acaagcaatg 284280 aaattcttga aactataaca ggtttttaag ggtgttgatc cccaaagccg tcttcactat 284340 tttgctccct ctctgactcg ctctgtctct gcctagcagc gctagtcttt tctacgtgtt 284400 tgatctgttg ttcctgtgtt taggcccatc cctactacac agcggaagtc agctattttt 284460 tctctttcct ttgctctgct gagcaagatt aaactctttt cacctggact tttcctagat 284520 tactcaggct gggtggaaat ggggtagctg tgaggctggg atgttactgt acaattcaaa 284580 tttatgatct gaacttaact agatcttgct gaagattgac ctggctagca cagttttgag 284640 gcacctatct ttcagtccct tctgtcctct tggcctggcc actggccaca tgttagtagc 284700 ttacttctaa ggatggaatg ccatgcatct cctacaaggt tgtctctatg cttcacacaa 284760 agtaaaagaa tggaggcaac tttgaatgct gctcattttc actcaggcaa tccctttaca 284820 atattgtgct tagtaaactc cccccactct ttttttccct tagcttgttt tttttttcta 284880 ataaaagtct atatcaattt gatgtattag ttagggttct ctggagaaac agaaccagta 284940 ggatcaattg attggtcaat caatcaatca agacaaaaag agattcatct ggaaggagtt 285000 gattcatgcc attgcggtca ttggctagtc tgaaatctgt aaggcaggct ggctgactgg 285060 aagctcaggc gggatttctc tgctgcagtc tcaaggcaga attccgtcct cttggggaaa 285120 cctcagtctt tgctcttaaa gctttcaatt gattggatga ggcctacaca cattatggag 285180 aataatctgt tttacttaaa gtctactgat tgtaaacatt aattatattt aaaaagtact 285240 ttcacagcaa catttagact agtgtttgac caacaactgg gcaccacggt caagccaagt 285300 tggcatatag aattagccag caaacttggt attcacaatc tgtcattata gtcttatcta 285360 taaacctaag gtttagagaa acgctggtca ttctgaacaa ttccctgtga atgcagagat 285420 caaggagcct ccccttaact gggtaggcag tgtgaaatac ctgcagtgta cttgacctta 285480 ctgttcaccc actggcagct gttcctacag cttggcttca gatatataat attacattgg 285540 ctaacttcaa agagcattgt tttccaagga tagagatggt gatggtgtat attactttta 285600 ccagccccag acctgtaaga ggttctcatc tcttttgttt aagattttgt tgtttttttt 285660 taatgctcaa taaaagaagc tttattcttt cattaaaaaa caaatctcag aagaacaggg 285720 aagaagaggg tagcctatga aagtgtgatt gttatttgat accatcgtga cttagcttgt 285780 tttcacctaa gactctgaga ttctattctg tttatgtgag atttgggctg agttcaacta 285840 ctatccatat taactgaatc ataaaacaat taatccatca tctggttaca ttttggtggg 285900 gagggagcat ttaacacaac actaagccac atatttcact attttttttt tttgcagcaa 285960 attgacttaa ctgcttgctt tcacaccatg cctataaaac ctttttggtt ttagaggttc 286020 tatgtgtctg gaaagtacag tgaagtatct catcagaata gtattaatat ttcttatgac 286080 atttcatatg tcctgatatg ggttaatgga gaaatatcat aagagtagta attctcttgc 286140 tgttattatt tgtcctattt agacaaacag aacatagaat taataagaat tcaaaaactt 286200 taatcactga tagagattaa atgatgttta tattagtcat catcacctaa tatcttaaat 286260 atttaacctt ttatgcagtg tttgcctctc tacttgggta tgcccttaac agtaaaaagt 286320 gttgataatg ctctcccttt tggcactcac agaattgcta tacatatata tgtataaaat 286380 atatgtaaat ataaaaatac atagttaaaa aaataaatct accactaaat atagtaaggg 286440 agttttaaac tgaggttttt gaagtcttta agaatttatt tagagacttc ttttgttgga 286500 agtatggtgg ctagatgcca tgaaaaaccc actgaaaaca agtgtaagtg ctaggtaata 286560 tgttgaaaca tatcttttga aatgtattac tgagctggca agaaagtatg ccattgtaga 286620 gagtgaaaat aagtgaaggc agaatcctgg gaggtaagcc agcctgaaga tattgatgac 286680 actggatggc cttaagtttc cattttgact ggcatgtaat ccagccaaag attcccacag 286740 aaatccgagg ttccaaatgg taaatccgtg gtgacattgg ggtgaccgag aaatgaactc 286800 tgtgcagaaa ggaatggtaa caacacttgt ctcgtacaac tttggctctg ggtaggggaa 286860 aggaaaacag cttcctagag aaatgttaac cacaagctag ccctcatgag agatttcagc 286920 taggatggat gctatctgtg tagtgcaaaa aaaaaaaaaa aaaatccata gccagatttt 286980 gtgctttaat gtggacctag gtcaatagtg actgcaaagc cagaagcagt ggctcacccc 287040 tgtaatccca gcactttggg aggccgaagg aggtggatcg cttgaggtca ggagttcgag 287100 accagcctgg ccaacatggt gaaaccctat atctactaaa aatacaaaaa tgagcctaga 287160 gtggtggtgg gtgcctgtat tcccagctac ttgggaggct gaggcacaag aattgcttga 287220 acccaggagg cggaggttgc agtgagccaa aatcgcacca ctgcattcta gcctgggcaa 287280 cagagtgaga caccatctca aaaataataa taataaaaaa aagtgactgc aggggactgg 287340 gaagaggaaa cacaaatctt tactggggaa tggaatttca agtgtatgca ccaaccctta 287400 gaaatcacaa aacatctgac ccttctgaaa ataaccacca tgagtgagac agcaggaaaa 287460 aaaaaaagaa aaaaaaaaaa aaaacaagga aagagaggga caatagaatc agactcatac 287520 ctacaaaact taaaaattaa ataaaatgaa tcagactcag aggcttcaga gtttgattta 287580 aatacattat acaaaagttc tgtgtgaaat atgtttaaga tgtagaaggg tgcttgaaat 287640 gcacaaagtc aacagctgaa aaattgacca agcagatatg aaaataaaat ccaatagagg 287700 gcatctggaa ataaaaaagt ataataatta tagtgaaaaa agttattaga tgggttaatt 287760 agtagaatgg atatagcaga agaaagattt agtcaactga aaaatatatc caaagaatag 287820 gtccagaatt aagcttaggg agataaagag atggtcaata cgaacattag gagacatgga 287880 gaacagtgta cgaaggtgta ataaattcta actggagtta aagaggagat agtaaagagg 287940 aagaaaaaac acaaaactca aaaaatgtag tggctgagaa tcttccagaa gtattgaaag 288000 acaccaatcc acagattcag aaacctacaa tttgcaagaa aaagtaaaaa gaatttcaca 288060 ccaagatcca tcttcatgga ctggcagagc ataagagatg aagagcttat cttgaaaatg 288120 cagccagaga gaaaaggtct atcgcagtta aaggaagagg caagcagatg actgagttct 288180 caatgccaac tgaaaatgag aagccagtgg cacaccttca atatgttggg agaatataat 288240 tttcaactta aaatagtgta cattgtaaaa ttacatttca aaaaaagagg gtagtataat 288300 gacattatca aataaaaacc atcccttata acaaatatca ctaaagaaac tgttggagga 288360 tgtagtttag gtttctagaa aggatgtctg atatgcaaga aagaatggta agtcaaatat 288420 tgagaaatat gtgaggaaat agaaacaaga ataactaatg aatcaatgat actgtctaat 288480 ttgaaggtta aatgattagg tagaactaaa atatgaaaca ataatagtat gtaagtcggg 288540 aggaggagga tgaagcttga agtgctctat gcatcttgca tctctggtgt ctttcttgtg 288600 tccaaacttt ttcttctttc aaggacacca gttagactag attagggtcc acctaatgac 288660 ctcattttaa cttatttgcc tctttaaagg ttctatctcc aaatacggtc ccattttgag 288720 gcactagggg ttagggtttc aacgtataaa ttttgggggg acacattcca gccgatagca 288780 attataaata caacttttat agtaaaagcc catcttctag aacaggtaga gaacaaggtt 288840 acttattttt tttaagaaca aaattggttt aaattatcct aaaatgattt taggagaaaa 288900 tggacattaa atatacaaca tttcctcctt tattatttta ttgatgactt gatatgtttt 288960 ttaaaactca gtaaaataaa tgattagtct cataatcata agagagttat gcccttattt 289020 taatgccata aaactgtgac ttctgaagaa atacaatcat ataaaatcat attttaattt 289080 acttttgaga atgtacagta actcaggaag gcagagtgtg gaacctgctt taatgaatag 289140 ataagaatga ctagcaatta aaaattaatt atctataatt cttctgaagt tcttgaaaat 289200 aatctcttct aacctgggta aatattcctc cttttcagaa atgtttgcaa tgttgctttt 289260 ttttaaatta atctcttttt cttagataat ggaacataaa tcttaggcac atttgctttg 289320 taaataccaa attgcacaca gattaaaatt taatgagctt ttactgctgt aatctcaaca 289380 agcagagtct ttgctgttgg tttttcaata agaaatactt tattttgtta tacagtggtc 289440 attaagaacc ttaaagataa tcaggacaga ttttccaaat tgcataatgc tattgcctag 289500 ctatttgcat gtattttttt taaatgacaa gacatttcgt taaatattta cttgcctgac 289560 gttgaaagat ttagacaaac aatgtacttc tagttgtcac tttttcaaaa agattcttag 289620 ggaaaagtta gccgttttgt tggttggtaa gtgatgggtt ttcttggaac gtgttgcttg 289680 ctaattttac cagagaagaa aataaattca aatggtaagc tacattccaa tttgtattct 289740 tcttctaaag tcctccctgt ttgcattctc ggattttgac actcctacac accagttaaa 289800 gcacttgtta gagtgtccaa aaaattgttg caattaattt cccagtctct tctctctttg 289860 atgtgtcact ataatgcttt gagtaatttt cagtgtctgg catctgttca aggacaattt 289920 ctggatttta ggagggggag aagcaataaa ggaaacaaca tatgtttttt cctaaatagg 289980 aggcattttt tgtttgtttg tttgaacaaa aatcaaaaac tttcttttct atataggtga 290040 caaaaagata cacgactcat tggttgttaa ctaccattgc attcttttct ctttggagta 290100 gcccttaagg accagattag accagccatc tgcatcatgt agcatgtctg ggttaccttt 290160 cccaaaagaa gttcagatag atgaactttg caaaccagag ccatctgaag tttgtttttt 290220 ctttttgaga cagagtctca ttctgttgcc caggctggag tgctgtggtg caatctcagc 290280 tcaatgcaac ctccgcctcc cgggttcaag cgattctcct gcctcaacct cccaagcagc 290340 tgggactaca ggcacgtgcc accacgtcca gctaattttt gtatttttag tagagacagg 290400 gtttcagcat attggccagg ctggtctcaa actcctgacc ttgtggtcca cccgttttgg 290460 cctctcaaag tgctgggatt ataggcataa gccaccacgc ccagtccatc tgaagtttta 290520 aaatggctgc aggtatctta gtaggagact aattttattt tccaatgatt agaaaaaaat 290580 gaccagacca agaactctag ggttatgttt catctcatat cctgtgcagg atgttctgag 290640 aagtttctat ttgtatctgt ggagtggttc tagtcttgtt catcttgcat tttaaggttt 290700 ggaggtattt tatcttgcct tgcttcttta ccaccttgct ttaatttccc cctatattgc 290760 catttctaaa gtaatgactc attttcaagg gtgggtctga aaggaaagaa ataataaaac 290820 cagagatctg gagaagtttc tcgttcatgg tcttattcac tttttaataa gagcatctag 290880 aacagtgagt ggtgccccag cagatatctg gaaatttttg tggaattgaa ttgaatttgt 290940 tcttagagta aatgacaata aagaaaatag tattatggaa actttcgacc caagggaaat 291000 atcaaggcta aagttgctat attatttttc ttctgatgga tgctgagttt ttctccttaa 291060 aaaacaaatc cacatttaaa cataaggcat tgtttgatgg cctatcacat tcagtagaat 291120 ggatttgaga aatacgtgta ggatgcctat taaaaactct gttttgaaat taaacctaag 291180 actataagat tgtctgttta aaaaaattat tgctgctgta atttgagcaa atctgaacta 291240 tattgaactt tagaaattca aatgtatgca atcttgtaat ataacttact ccatcggtag 291300 acatagttct ttgtcccacc tggcttccag cagtttgtct gtctgtcatt aggctaaact 291360 cttcatgttc ctaaacatgt tttcctcaaa aggggacata tttcttgggt cagatgtaaa 291420 catcaagcta aggagttctg ctgtgcgtct agacaaataa ggttcatttt catcctctac 291480 atagtgttaa acttgaattt aagatcacac agattccttt acacgttacc aatgtaatga 291540 tatagacaat ctcactttat tcattcactc tgtttaattc attcaataaa aacgtataca 291600 ttggctgcct actgtgtgcc agttggtgaa gatataaaga tgattaaggc aagggtctgt 291660 gctgacatgc ctaatgggca ggctgacaca cctaaacgcc agggaaaaag agggatgaga 291720 cctgggcctc tgaagccctg gccacctggc tcgaagctca ctttaatgtg cttctgggtg 291780 tattccatga ctttttaaag gcgcttatgt ttcctttctg gtaaagcatg tttaacatgc 291840 aaaatgctta tttcattgag tagcttttaa aaagtgttca tagaatgtct agaacagtgc 291900 ttgtctaata gaagtataat tcaggtcacg taggtaatat taaattttct agtagccaca 291960 ttaaaaagta aaaagcaaca ggcaaagtta atattttttt ttttcctgag atggagtctt 292020 gctttgtcac ccaggctgga atgcagtggt gtgatctcgg ctcactgcaa gctccgcctc 292080 ccgggttcaa gccagtctcc tgcctcagcc tcctgagtag ctgggactat aggcgcccgc 292140 caccacacct ggctaatttt ttgtattttt agtagagacg gggtttcacc gtgttatcca 292200 ggatggtcgt taattttaat aatatattca ttaattttaa taatatattc atttagtcct 292260 atataaaaaa attagcattt caacatgtaa tcaatagaat atattattag tcaactattt 292320 tgcattcttt gttttgtacc atctttgaat ttcaatttgt attttatact tacagtgcat 292380 ctcaatttta atgctaaatg tcatcggaga tattcgatct ctgtttagct ttaatatatt 292440 tttgggttga aaaagtaaat tcacataacc aagttcttcc aaatatactt gaaagtgttt 292500 ctgataactg agttatcaac ttaaaaatgt aagttaatga caataaatga aagaaaaatt 292560 ctgttcctta gctgcactga ccacatttta gtgttcaata gtcgcaggtg gccagtggct 292620 atcatattgg atagtacagc tttagaatga cagttcagtg caacaagtgc tataatagac 292680 tcatgaactg gaagctccgg gaagttaaga atgggatcaa tgaagtgggt cttgaaaaac 292740 caataaaaat tcaccacgta gagaggagga gggcgactac tccaattcaa tcttttgaaa 292800 gcatgtgaag gagcaacagt agacttcttt aattatttaa tagtaattta ttgaacatga 292860 attatgggag gtgcatggtg tgggtgctgg tgagacatag ttcctgagct caagtagctt 292920 ggtgtctaaa tattcatggg cccatttttc agaaaggatg gatatatgtg tgatcctggg 292980 tgtgccaaat gctgtggctt cctgaagctt agatttccag cttgtcacct tcaaggttac 293040 cttgtgaata ggactttttt gagctgtaag taaatttact ttgcctattt atttccaatg 293100 gaaaaaaagc ttttttaaaa aataaatctc atcttattgc ctatgattgg ccaagacaac 293160 atggcccata cagaaggttt ttgatggctt ctgaggtctg ttatcatttg cttattggca 293220 tttcagctgt caaccagggt tctgtcaaat tccattcctg cctttagctc ttttacttga 293280 atacctgggg caatggcaga agtggttgct atttgtcacc tttccaggat gttagtcgtg 293340 tccttgagac aaatagaaaa tttaaagtca gatgacttga ttcctctgcc agttaagacc 293400 cttagagagt cctcagaatg ttgcttattt ttaaatttca agtccctggt aaggatcaag 293460 taaactcccc aatttgcaga tttctatcca gttgactatg gattttgcct gttgctttgt 293520 ttccaccaac tctccctgaa gatgaggcgc acagacagac aactcacagg caagaacagc 293580 ctggtccatc ttgaaagatt ctcaagacta ttctccacaa gataattgtc tacttttaaa 293640 aatattcagt aaagggaatt tttgctgtta tccttggttg tgtttttagt atctcatcat 293700 ccttctagtt gtaggaggct tttcctaaca tctaacccat atgtctgttg tctcatcagg 293760 tgtttctatt aaggctactt ccccatcaat cttaattttt tttttaatct tctgagatgt 293820 ataggttaag ttgaaatcag agactttcat aaaatggtaa gatggccatt taaacgcaac 293880 tatgaggaaa taatgtaagc aggattccat tggagaacca aacactagca acaactaact 293940 tggtaatcaa tgttgggact tgaagttagg ctaaaatcaa tagtaatggc actcgtatgt 294000 acaaatgcag aactttttac acacaatgat ttttccctct gttattatac actagctgtg 294060 tctgagtaga cagtccagct ccactacctg cagtccaccc tgggctgtgt aatctgagca 294120 ctgatgggct gttatttgta cgtattactt ctatgacact gttttttcat ctgtgttaga 294180 aatgtctttc tttcttgaat aagctgcttc aatttcttat agacagattc tgcttttatg 294240 acccttgttt ctacaaagta atctctactc atgctgaaat ctcagacaat tttaacaaat 294300 atttagagta cttaattttt ctttgaattc taaatattat ccttctttag ttcaccatag 294360 ttggatattt tgagataact gtggaggaaa cagcactgat cctggggcca tgaaacctga 294420 tttcaagatc tagtcccttc tttaattttg cacaactaat ttaatcacat tcatccttaa 294480 tttcatcatc attaaaatag cagagaataa ttcccgtttc atggagttga tatgcaatga 294540 aatagcatat caatgtatgt atgaatgtcc cccaacatag agtactacac aaatgaaacg 294600 tgtcactcag cataacgtta tgtgctcctt cctgcaactg gattgcactc cagtgggatt 294660 tcatgctggt gagatggctg tgctgctgga cttcatggga caccaatctt tgaaaataag 294720 cctgatctgg ctgggcgtgg tggcttatgc ctgtaatccc agcactgtgg gaggctgaga 294780 cgggcggatc acctgaagtc aggagtttga gaccagcctg gccaacatgg tgaaatccta 294840 tctctactaa aaatacaaaa aaattagctg ggcatggtgg catgtgcctg taatcccagc 294900 tacttgggag gctgaggcag gagaatcact tgaacccagg agatgaagac tgtagtgagc 294960 cgagattgcg ccactgcact ctagctgggg caacagagtg agactctgtc tcaaaaaaaa 295020 aaaaaaaaaa aaaaaaaaca caaacaaaaa aaaaaaagaa aaagaaaata aacctgatct 295080 atagatgagg ccagtggatc ttgtgaagag ttgaaaggtc aggtatcagt cttataccat 295140 gtcggatggg gcaatcgtca taacttttta aaaaattatt tatttatttt gagacagtgt 295200 ctcacgctgt cccccaggct ggagtgcagt ggcatgtttt cggctcactg caacctccgc 295260 ctcctgcgtt caagcgattc tcatgcctcg gcctccctag taactggatt acaggtgtgt 295320 gccaccatcc ctggctaatt ttttgtattt ttagtataga cagggtttca ccacgttggc 295380 ccaggctggt ctcgaactcc tgacctcagg tgatccacct gcctcagcct cccaaagtgc 295440 tgggattaca ggtgtgagcc accgtgcctg ccccaattgt tacagctttt taagtggatt 295500 atatgcctgc ttcaggcatt agacataata agttaatctg ttgataagtt tcttcatttc 295560 ttaattttca gttgtgtttt gatgtgtgtg gtctgggtga gcggctcagt gctgctgctg 295620 tggagaaggc gtgatatgga agggatgtga ctgtccttct tcatcttcat aacggggcca 295680 ggactggggt gaggtgtgtg agatgaatga agcactggtt ttgatacaaa atttaagaaa 295740 aatcaaattc aagaggtaat attttaatac gatatttgta aaaaatcaaa attagtgcaa 295800 aaatttgtga tgagcaaaat gttagataaa ggcattgttg cttttctttt tctgtgtatt 295860 gtaacacacc atcacttagt ggagaaacag ctctcacttt cctcctcccc agatacaacc 295920 atttatgttg aattaaactt ctagttctcc tatacctgtg agcatccccc aggccccttg 295980 gtatggagaa agcagtttat ttgtcttagt aagattataa aagtggcaat aaaatgtgaa 296040 tgtaatgaac aaaatgcaca ttttgtggac caacttgttg ttttagatct atttttgaaa 296100 actcattagg tatgtgcatg aggcaaaata attcaagtgc agttggatat taaatgaaaa 296160 agtgtcaggt ccccttttct gccatattct cttctgtgtc ttcattagtg gaaaccattt 296220 tgaccagttc ttataattct aatgatttgc tgatggctct aattcttggt ttatcaactt 296280 caagcagaat gtcttgacat cttggtatga aagttaaaga atatgaatca tttgttctct 296340 cccttctcct ttcctctttc tctgcctctc agtttttgtt gtatgctcac ggagtatgtg 296400 tgtgagcatg tgtgtgtgtg tgtgtgcacg cgagcacgtg tgtgtgtgtg cgcgcccatg 296460 ggtccatttt tgcatggcag gctttgtttt agaaagattg gttacaacag ctgccccacc 296520 aatctcctct acagggaagg attcctactc tgagaccttg gtcttttcca ggcagatcac 296580 ttacatttcc tcacagatta tttctcatcc tgcagcctgg gtccaaatgg gctttgctgt 296640 gaacagtgac tctcaggctt ctggtctctg ctgtgcttga gtgtcgttga gatgctccat 296700 ctcctcctac tgcacccacc cagcaatcat ctctctttca ggaattcacc aaagtctttt 296760 ttaaaattat tcttttgttt tgagacagag tcttgctctg ttgcccaggc tggagtacag 296820 tggcgcaatc tccgctcgct gcaacctctg cctcctgggt tcaagtgatt ctcctgcctc 296880 agcctcctga ctggcaggga ctacaggcat gtgtcaccac acccagctaa tttttgtatt 296940 tttagtagag atggtgtttc accatattgg ccaggctggt ctcaaactcc tgacctcagg 297000 tgatctgccg gggtccattt tacgtggcag actttatttt agaaagatag gttacgacag 297060 ttgctccacc catcccccct gcagggaagg agtcctactc tgagaccttg gtcttttcca 297120 ggcagatcac ttacctttcc tcacagatta tttctcatcc tgcagcctgg gtccaaagtg 297180 ctgggattac aagcgtaagc caccacatcc ggctcaccaa agtctttggg tggttgatgt 297240 catatgcctc cagttgatag cacttttaag aatttttcct ttttgtatgc tgttattatt 297300 tttagaaggc ttttggatta ttattgttaa agagtatgcc atgtctatct tttaactttt 297360 aagcatctat tgctttgtta cttgtacttt atatatatgt atatccttcc cccaataaga 297420 caaagagtgc aaataatcac ctcccttgcc tgttgtttgg gtttaattca ggagtcagtg 297480 gaattaaaag cctaaactca gtatagtttt aaagcagcag tccccaaccc ttttggcacc 297540 agggactggc tttgtggaag acagtttttc catggaccag tgtgggggct ggaaggtgat 297600 tccaggatga ttcaggtaca ttacattaat tgtgcacttt atttctatta ttattacatt 297660 gcaatacata aggaagtaat tatacaactt accataacat agaatcaatg ggagccttga 297720 gcttcttttc ctgcaactag acggtcccat ctgggggtga tgggagacag tgacagatta 297780 tcaggcatta gattatcata aggagtgcac aacctagatc ccttgtgtgc acagttcaca 297840 gtaggattcg tgctcctatg agaatctaat gctgccactg atctgacagg aggtggagct 297900 caggcagtaa tgcgagcaat gggagtggct gtaaatacag atgaagcttc acttgcacgt 297960 tcactgctca cctcctgttg ggcggcccag ttcctaacca gggttgggga cccctgcttt 298020 aaagaatatg tttgtggatt catagaggga aacaacacac actggggcct ttcggagggt 298080 ggagggtggg aggaggcaga tgatcagaaa aaatattaat aactaatgtg tactaggctt 298140 aatatctggg tgttgaaata atctatacaa caaaccccca tgacacaagt ttacctatgt 298200 gagaaacctg cacgtgtact ccagagctta aaataaatgt taaaaaattc cctccaaaaa 298260 ggatatattt gcatcggagt tatatttgta tatgagtata tatttgtata tataaatata 298320 cttgtatatg aaaaaaatat cttttttctt tcattttatt ttccaaacat taaagtcggg 298380 cacattggtt aggaatttca ccaatacttt ttacaaaact gaggacttgg atgataaagg 298440 cactttttaa aagattacac actggcatgg ggaataatac ctttataaag atgatctatg 298500 tgttcctgaa tatcccgatg catctcctag ctggatcttc cgctccacaa aaattcataa 298560 gatgagattc ttgaattaga atgcatgcct taatgtatta agtctatgta gagagagtta 298620 tttagtccat gtaaattaag tgggaatatt tttatttgat tactgtttta tctggatctt 298680 gcccacttaa ggccttcaaa aatgaaattt aaggcctgtt aagcagaccc aacatcaaca 298740 gcatattctc tctctcttgt aagtattgtc tagttgataa aaaatttcaa aaacatgtct 298800 taatcaaaaa caagatgatc cagcacaggt ttaataaatg ttttgtgaat atggcacatt 298860 cgtgtctcat tactacagtt ttcctatgct gtctttctca ataattcccc ccaaaattgt 298920 agtgtttaca ttatggcatt tatagttacc tctgaaccta aaaaattaac ttcaaaagta 298980 tttaaaaaaa tcattatatt taaaaccatt tcatgtttaa atggtttgta cagggcaatg 299040 aaaggaaatg tagtaataaa cacagaatca gatttggtca ctaatatttt tctgcagttg 299100 aaatatatgt agactggctt agggtctaaa tagcattgaa tcctgttacc ttccatctat 299160 aatcaattaa tgtattatga cattgttgtc ctcagatcac tgggatctca tggtaagtaa 299220 gtaaagggat tattctgtgc attttcccaa tatctatatt agttttaata tacctttatg 299280 ttaatgtatg acactgacac ttagtaattg gattaacttc ctatcagaat ttgtttttca 299340 ctcatacttt gtatacatgt cttaagggta gggtagatgt acattttttt ctgtgttagc 299400 ctatctgttt ctgtgacact acatgctttc tgtcctccaa tttgtgtttc tttccgtgta 299460 caaatatgca tcatctacca tctacatcta caaaacatgt aggcttccaa tgttttcatg 299520 taaatacatt tcatgagtcc tcagtagagt gttagatgag tggttaatta gtaatgttaa 299580 taaatgtaaa ttacaataaa aacatttata atgttaataa atataagttt attgaactta 299640 aataatttaa acatcttctg aaatgtagta gaaattatga ttagccataa ctagtacagt 299700 attttttgct tgtttaattt ttttggtgat attccatttg tggaatgagt gtgtgtgtgt 299760 gtgtgcagta cagacagaaa ggagagaaac atatctgcat gttatgttag aaagagtagt 299820 gttagctacc ctaccaaatt tacatactgg ctgaacacag tatgtaaaaa attatttttt 299880 tagtccattg ctggtgttcc ttgttgttgg gtgactctat tccacatggt gatgcaggga 299940 accaatctcc ttccttctgt ggctgtgtaa tcccttgcaa ccttgaagtc ctctgcatct 300000 aactttagga tgaggaaagt gaaggtggag gatatagccc tcttgactgc cttgacctgg 300060 acctggaaca tctcttttgc tcccattcca tggggaagaa ctagtgacat ggtggcccat 300120 agctgcagag gggaggctga gaaatgcagc ctctggataa gaagcctact cccagtggtt 300180 actgtacatt gtgggaggga agcttgaatt ctgatggaca gtgagaacca ttctccacac 300240 aataacgaaa tgacgtcttc tcaaccttgg caatgtagca tcctgtgact taagtatgta 300300 aataattatc agtacaggtc agtgaaaaat taggtcacct ttcccttcca cttttaattc 300360 tatagtttaa tttgcctatc tgctacatat tatatatatg ggaatagata agattatcta 300420 taaacatgta taaatttgtt tcctacacta aaaagaaaaa tgacaaagaa gaattaagtt 300480 agttgcccaa atccacacaa taccaccagg agaaagtcta ggaaccatac cttctaaatc 300540 caggtctaca cttctttagt gcactaaatt ttttcctaat atagctctga ggagactggt 300600 gtttaagagg agaatgttaa gccaaaagcc catttcactt ggctctgtac agacagtaag 300660 ttaatttcca ggatgtataa ctcctgattt tctgtgatga cagagaaaat actgacctga 300720 tttgggtaac tctgaggttt ggagatcttg aatagcctca tgttcctgaa cttctttacc 300780 atacatgaat tacttcttag gaagaaacat ttattctgta gaatttggtt tcgcatttta 300840 tttttatttt cttagacact ggtagttgga aattcaggaa gaatttgact acaaaaaaca 300900 tttattaaaa agagtttcta atctcacctg ctaagtgcta caaggaaaaa aaaaaataca 300960 ttttgagccc tcaaggggct ccaaatacgg ttgaaggaaa attagaccca gaatagtata 301020 tgattaggaa caaaacgatg gcagagaaat gagagtttag agaaaggaga gataatcctg 301080 agttacctta ggaagagaaa atttcacaga gaaaacggcc cccacactga tttggggaag 301140 atgattcaga cttgtctcaa tggcatgagg agcaggggcc agatgggaaa ggacatcgtg 301200 gtggaaatga cacgatgagc agaagcttag aagtacttct gcttcacgtc tgtgattctg 301260 cctctcccct tgtttctgca gtgctaagtt gagtgtagtt ccccacacaa accctgagct 301320 ttcttcccct ccaggctgct ccatcagtca gacaggagtg ccttctcagg ggatcctctt 301380 cctcatctta tcgggccact catctcgtcg cagacattcc catactcctg gttgacttgc 301440 tcttccctct ttttaactga catgagcagg catcacctct tccaggaaac ttccctgaca 301500 ccaggctgag tctctctggt gtcggggaag gcttctgtat tactgcatct gccattttga 301560 tttaaggttt tctgctcatt ccaactcaac agtgagctct ttgagggcag aaattgtgtc 301620 ttattcattt ttcttgttat gccctaaaaa tgtattgtga taatatataa gtaacgtaca 301680 atttaccatt ttcacctctt gaagtgtata gctcagtggc gttaagtgca ttcacactgt 301740 tgtgcaacca ttatcaccat tcatctccag aactttctca tcatcccagg caaactctgt 301800 atccattaca caatagctct ccatttcctc ctgccctcag cctcaggaaa cctcccatct 301860 actttctctt tctacgcgtt taactactca tatagatgga atcatccaac atttttcctt 301920 ttgtgcctgg cttatttcac ttgacataat gttttcaagg ttcttttatg ttttcttatg 301980 cgtttttata tctctctatc tttgatagca cccaatacat agaagacaat gaatgttttt 302040 gtgagtgaaa acataagacc agaaagaaat aggatgtcat attctaggga cactcaagac 302100 actttcttga ggacagaggc actgtagctt ggaatttgga agatgaggtt ggcaaggtgg 302160 gtggggaaag gatggaaaag tgatacgttt cttgaagcat gtggatttgc ttccataagc 302220 agtggtggac cagtgggcac ccttatctat taaaagaatg attttttttg tgactcgtgt 302280 agagcactgt cttagttacc taccccagtg gtagataaga gaagcggatt aaaaagagat 302340 ctgaacctga ggaaatggag actaccaagt tttttgtaaa tatgtctgtt ataacatata 302400 ttatctagta cttgcgatgc ctgtgccaaa gcatgctttt tggtttagtt aagcctactt 302460 agctcgctaa tttcagtaat tttggcttga attgcaaaaa gttgatgggg gagatggggg 302520 agtctctgac atccttcccc cactcacagg tttgaaaaat aaaattatga agagcaaaag 302580 gatctttttc tgtggtaaat tgtacttcat gacaataaac gagttgtggt tttagtggtt 302640 aatttataaa ttaggccatc tggttcttct gtaatctaaa gatttttata tatatgtaaa 302700 atacaaagtt gtcctgggca actgccaatc tataaaggag aaaacatctt gaactctgtg 302760 gagataataa aaccatattc agctgccaaa gtgctgctga catactgtcc aatgagacac 302820 ccaacgcctt tgcattacag ccagcaaggt gtggagctag atgtattgat ctatttaata 302880 atattagctt ctcttctctg ggtcggactt ggcccagagc aagtgaacag gacctatcta 302940 tctccttctc aaaagtcaca gctttcttac caaattgtac aactcaagcc acaaagaaaa 303000 caagtcaagg aaaggaccag aggagcacga gggcacatgc cttgttccca gaccctggga 303060 ccagctccag ctctggctcc ttgcagatcc cgctcttctc aagttctctg gctttgatcc 303120 tagttttctg ccctactatt cctgacatgt acagcactta gcaattcata acttgcttta 303180 ttaaccaata tctcaacaga acttttaaac aacctgggag gaagcagagt gggtgttact 303240 gtcctcattg cacagataat gaaactgagg ttcagaaagg ttgagtgtct tgcccaaggc 303300 cacacggctt cttagtggag aagccaggat ctgcaccaat gtcttccatt ggacacactg 303360 ccacttaata tggtacttag tttttctttc tagatgaagc agtatgagga attctaccat 303420 ggatatctct ctctattttt ttaaactgca aaataatgat aatgataata atgaatactt 303480 ctagaataca gtctctatgc caggcactat atgctttata tgtactaact tgcttaattc 303540 tcctaacaac cctagaaggt agttactaat attatcacta tttttaaatg gggaaactga 303600 gttacagaga tggtaaataa gttgcccaag gtcacagagg cagccagatt agtgacaaaa 303660 gtttgagagt actcagtttg aattttacat gttccgtgga tatggtttat gccaaatacc 303720 ttctcctttc tagacctcag tttcctcatg tatcaaacaa gtggactgca ctatacaact 303780 ctgaggtccc ttctagcctg aagattagag tcttttatgc ccacatgata tggaaaacat 303840 taatgctggc tctttaagac tggaaccttg tcatttaaaa aaataagctc tactaaattt 303900 gcagtaaact gtccaaatac gatctctggt ctctgatttg tatctctcac agagcatgat 303960 acaatgctag acacatatat actcattaaa aacttgctga attaaattgt aaaacattcc 304020 tccagataga ccgtaagggt gagctgatgc cctaatatgc tcctcagctg ctgacttagg 304080 acccgtgggt gacaaaccct gtccttgttg ttccatctgt gacagtgggc agtgtccaaa 304140 atgagtctct tcatcaaaag tgagtccagg aaactggatc agagtaagta aggagtcttc 304200 cttgcttctt tttctctaaa atacaataca gtgcattcta gcaaactacc agcatgccta 304260 taaatctcat tttaaaaata tcaggaaata gatgctcatt gataaagagg gtaagaatga 304320 gcaagggaga gagtcaagcc tgtacatttg tgcttagggt attttcattt gagaaattat 304380 cattggaaag atcaatttcc aaggcaggcg ttttgtcttg acttaataaa ctaatcttta 304440 tcaataataa ttaaataatg tcattttccc agatacaaag gggaaaccat aatgcctttc 304500 atatgccttc tcatatcttc agtgtttctc aaacccagct gtggggtctt tttagggaag 304560 atacaaggag ggtgagacca tgtggagcac acactcagca gccactgtga agtcatgggt 304620 cccttgctac ctttggaagc tgacaatctg catgaaaagc agcccctagg aacatgggta 304680 gtggcccggg atccaaaact cctgaatcca taaaagggct tttgacttct tgttccagga 304740 caagtgacat ctgacatgct tgcctgcttg tttgcctttc ttccttctcc tatccgtctt 304800 tccatccatc tgtccatcag tctatctgtc catccagtca tccatccatc cttccatcca 304860 ttcgtctatt catccatccg tccttccatc catccatcca agatttattg agcacttaca 304920 tgacaggaag tatgagacac aaaagaaaat tctacacaat tctcctaggg acatgaacta 304980 atggttagca aaaatatatg ggaagtcctg cttcaagtaa aattatgact taagatatac 305040 atcagatatt tgaaaaagat atttttaagt tcaacattga aattctaact acattgtgtc 305100 cttaatttct attttctagt tagacttttt tgaagataca aatcatttga attatcatta 305160 ttattgttac ttgattttat ttattccaca tgaatggtaa gaattttaaa ggaaggtggg 305220 tgccctaaaa atacatttat gccaactgga ttgaatcacc ttgaatcaca atgagtacaa 305280 caactgctaa tgagctaaca cttaatgagt aatgaccagg caccagacac tgttctagca 305340 ctttatactt actgatttct ttactcttca tgataaccct atgaggaaag tgcttttttg 305400 ttaagctcca ttttcagctg aagaagctga ggcctggaga agttacatag ctttctcatg 305460 gtgtctccac tatgaagtag ctgagctgag atctcaccca aggccctgct gggttcaggc 305520 cacactctta agtactcaca gctgcatcac actgaatatc atctccctgc actgccattt 305580 catttgagca gggctttgcc tgtcaagaac attcatatct tttgataaac agtgcatttt 305640 ttccctgata gtctgtatgg gacagcctcc ttgtttgcat ctgaaggaca gggacttcag 305700 gacctcctgc tgtggtcacc aaggaatcac attcaaactt ctcagcaagg tgttatggtc 305760 cttctcagtt tgcctacgat ccattgaggc aaaggtttcc ttctctcaat acaccctctg 305820 ctttagccag ggggacctcc cactgtcctc tctatgtgtt ctatttgttc ctgactgtta 305880 gtacccgctt gtgtggtttc catgatcctt cttctgcctg gaatgaggct cctcttgagt 305940 cctgagagct tcatttctgt ctgtcttttg ggctgtgcca aagcccctct gccttcgtgg 306000 actccccact gattcattac caattttcct ctcctctggg ctcttcttag attgcaaatg 306060 gtgcctctgg attgggtacc aagacttgca gtgccttatt ttgataccac taatatgaga 306120 ccatgttata tgcctcttga gatatcattc cctttctagc aatagacagt gataagcatg 306180 cgtatagagg gtaaacgtag gactttgagg ttcatccatc tcaatagaca aaagtaaaag 306240 tatgctaatt tcaatccttc acacagtaaa ttgaatgtaa taggtcttca gtaactattt 306300 gaggaatgaa attgttattg atatattgat ttaactgagc aaatccataa gtgccacgct 306360 tggagtaaag tacagggaat ctcatttttt gggtaatttc aaacaagtag gagaccatcc 306420 actatctatt aaggacaaag gagatttgag tgacaaacat gttccagacc atccaatggt 306480 gttattctac tacttcatcc cagctagtaa aatggggcaa taagaaccaa aaagcaggta 306540 ctgtccctat gtaagtagac ttcctagtcc tggccaaaac aaaaacaaaa aaaaaacaaa 306600 gcaacacaaa acaaaaacaa tgtgtgaaga gcatcttacc gttcattgct ttggatgatt 306660 tgtgcaaatc tagttaatgg gggtggatct gatcagtctt tgtaggaagt cagtattggc 306720 atatgtctgg cttctgaatt ttctaaaaat ataattattt atttttaaat ccattcaatc 306780 aacactgaat ttactaatca actactaaat aagtaaaaga tcctatagta gatccttcaa 306840 gaaatggaaa ttgagacatt aggtcactat aaaccccaac ccttgtaatc tttttgtggc 306900 aaccttagga aacttggaat gctttttaca ctctgataaa ggtttaattg taatcatagc 306960 cccagtgttg caaaatgagt cagaagatac aaagtatctc ataggataat attatagctg 307020 taggtacttc aaatggacaa gtataacaca ttatgactgc taatatggat gcattgggag 307080 gaaaataagc cctaagaagc aatatgcaga aaagctatga ttgctggaga cagatagatc 307140 caagaaccta ggtaattttt cagcaaactg tggttccact ttcgcctctt tcttgacatt 307200 gactgtgttt ttaacaggga aaaagttatc tgaaattttt gatagagttc aaactttaaa 307260 tcgtgttcac tttgctaaaa ctccactgga tggagtggca gaagagaaaa aacacagaaa 307320 taaaagaaaa gcagtaatgg agaatggaaa atctttaaag atgctaccat cctgaaaaga 307380 ttcgaaagca agcccaggaa agccacgggg agggaaagag cgcttagagg tgtccccaaa 307440 gctttcagaa gtgatgaggg aaaccccagc tcttcttgtt acttcttggc attttgttcc 307500 tctatacgtt agcttttggt taatctttca tgttacttat tatctctgtt ttaaaatttc 307560 acattaactc attggtttca tatcccactt aacaaattag atattttcct tgggcttatt 307620 aagaaaatta tttgctctca tatgttatgg ctttagattt tctgtgtagc taggactgtt 307680 cttaaatttt tatctttacc tttgttattt ctctgaagca tccccattgg ggtggcagtg 307740 gggggtatta aatggttatg taaaatttac atgtaattgt gcaatttaca catagcctca 307800 aatataatga ggcctagtct agctgcccat accaagagga tattatagtt gccaataaaa 307860 tcagtattat ttcttttttt tttctgttct tttttagctt cttgcaaaca ttcactcaga 307920 atcctttttg aatatcagtt ttgtgaaaag caccgtgctg ggttctttgg gaaaagccaa 307980 gatgagggca aatgcatcct ccttcctagt gagtctagca cacagatgac tcaggaagtc 308040 atgcactgga ggaggagtat cttctagaac tggggaaagg ttaaggaagg gatcagaaac 308100 ctttttcact caaccaatta cattttcctg aaagcatgtt attaatcgta catgatcttg 308160 cagaccccag atagagacta tatcactata tcaattgttt tcttgaacaa ctggagttaa 308220 ttctcatatg tttggttacc cttcaagtat ttatgtttag gatctgtttt cttcctctta 308280 acttacattc caaagtttag gtatccttcc cctccatttg ctgtccaaaa cagcatcctt 308340 tcatgtagct acatgccatt ggaatgattt ggtttttgcc atggattcct agtcctaaat 308400 ttggactttt attggtatct aagatgtcat ggacagaacc cacagatgtt gtacaaaaag 308460 ggctgagtgg acagtccaac agagttacat catctgttcc aaacaccctt gtaatggttg 308520 tatcagcgtc aatgtctgag ttgctgtcct ggttctcctg gccagtcctc agctggccat 308580 gcctgttcag gcaccagaga aagcttcata cctcaggcaa atctttacaa gggatttgaa 308640 aggcaagaaa catgtatttt ggaggtttta cctgtttatt tcatgtatag cttcatatta 308700 acagattttg ctatcactta aaagtaaata aaatgatttt gatttctcaa aatcatctta 308760 taatttatta atctatttta aggcttgcat ttacatttaa tcttcaaatc ttgatgcatt 308820 ttcacagagt ttctttagtt agttaaggat attaatgact tcctttaata gttgatgaag 308880 tgagtcatca tcgacagtga gtcactaagg ccaactcttg tacctgctct taaatagcag 308940 ttgttttact agatttgtac tgaaaccttt ttaaaaatct gtttgtctta tatataacaa 309000 gcatttccag tagttaataa tactttctta gctcttcaat cattttatga gagcattaca 309060 agaaaagcag gagatgggga aagagatatc ttgtttgcca tgtaggatgc atgaaattct 309120 tacttagtct gttgtgtttt ggattcgaga gaaaatatgt aatgaatcaa aatgtttcct 309180 acagtcctct gaaaagatgt aatgagacag tcttccagca gcctttgatc atctgggaag 309240 tcattgactt tgatccttat cctatcaggg gctcttaccc tggggtccat aaatacccag 309300 gcatttttaa gaagtggatt tcagtataac ttgtttcatt ttgtgatttt taaaaatatt 309360 ttgttttatg cacttaaaac cttaatctga gaagtcatct gtagactata ccagatttcc 309420 aaatggaata aaaatattta agaactctct tatgtgtgtg tttcaaccta taaattttat 309480 atgtgtagct catggttagg tggtaagtag agaatttgct atctgtgtaa tatttggtac 309540 tttttataat gaaaaaggaa gtaatacaat gataggtacc atttatttgt tgaccaccca 309600 tattttccag ggaatgtgat agatactttt tatatattct ttctagtttt caccataaca 309660 tgctgcaggg atagtgttac cattctcatt ttgcagatga agaaattgaa acccagaaca 309720 attcgttcat tcattcaaaa aatatccata gagcatacac taagagaagg cactctgcta 309780 ggcaccagaa attgaataat tgaccccaaa tcacctaact cataagtggc aaagctggac 309840 ctaacaaagc ccattatccc ttctatcaca cattccatcc tcataatatc atattctaca 309900 tagaaaaact taacagtcct gttgagacac ttggaactct aagaaggtag tcaacagata 309960 cttttctctt tatataaata tgatatctaa ttagcttttc ctggaaagga gtgattctgc 310020 ctttttttaa ttctagcatt ccctgagcaa attagagccc aggtaatgat ttcctgagat 310080 aagtcaattc tcttctagga caatctctag tcttgtcatc atgagatgga ataacaacgg 310140 tctatgtcat ttcagtgacg gcacctgcat gtccttgtat ctaagaaaag acacctcctt 310200 ctctgccttg ctaaatattt gtaaactttg ctttaattgg tatatgtgcc actgttttgt 310260 atgtgggagg ggtttatggt tttgttttgt tttttggtct tttttagtaa ccccaatcca 310320 aactattctc atttgtaacc taaaatactt agaacaagag gctttgcaat cttgaagacc 310380 gaatacattt ttactactaa atgtaaggca gatttgagcc acccattttg tagtgcttga 310440 ttatggcaac ccgaggaaac taatacggtt actctttatc tttattagga aatactgctg 310500 tagttcctgt tgtaatcctt agggagccaa cattgttgat gagacctagt accaagccag 310560 aggccatgtt gaactagcaa gatatgggat agtttttact ttcaaagtaa ttagcatcta 310620 gagtctagag agtttctctt acagggtggc ctggtgtctt agtctatttt ctgttcctat 310680 aatagaatac ctgagactgg gtaatgtaca aattataaag atttgtttga ctcacaatcc 310740 tagaggctgg gaggttcaag atcagacagc cacatctggc catcctttaa tgagggcctc 310800 atgctgtgtc ataacacagc agagaattgg aaggagaaat gggcacatgc aaagagaaag 310860 aaaggggacg aaaggggcta actcactttg taactatgag actaatccat tccctggaga 310920 actaatttat tctcatgaga aagacatgaa tacatcttaa catcctaatc acttcttaaa 310980 ggcctcaact ctgtacactg ctacattgta acaggcaatt aaatttcagc atgagttttg 311040 gtggggacaa actacatccc aactgtagta cctagctacc cactttattt ttagagtggc 311100 tatttaatga cctggcaaga tctactgtgc ttgtaaaaga atccaccatg ggttaaagaa 311160 aaatagtttc tggcttccag tctccttttg gcctctctct agaatggcat atacaagttc 311220 agtggttact gacttcaaag gtggggtgga agacactgaa atgaattttt ctcctttctt 311280 tggttggttg ctctctctct ttgttgctga aatttgtgta ggataatgga atgaatatgg 311340 gagataggga actatagaaa gactggaggg aagggagaag tcttttctga attaaccccc 311400 catgtgcttg tgagaccctt ggaccccaaa gggctcctga ctggctgggc ccactccttc 311460 tgtatatgga gccatagggc ttttctctgg cttcccagtt gaagcattgt catatgcttt 311520 gatgctcagc atttctggca attttacctt gtaaaactcc cgtttcgaca ttctgaactt 311580 aagtagaaaa tgggaatata agcctcttgt tttttgctct taatccattc cagaactata 311640 agtccctggg ttcttggcaa caacaggtgt tcctctagat tttaaatcaa gtgtgtgtgt 311700 gtgtgtgtgt gtgtgtgtgt gtgtgtggaa tatctcacta aaacgacagt gttgtcatca 311760 attttggctt catggagggt cttgagctgg gtggagatgg gaggaagcta tccttgtcca 311820 tgcggtttgg agacttgctc taaaaaagag accgtctact tccctcgtag tttttgtttt 311880 gaagacattt gtagtgttta ccaggagcat acagttatct ggaaaatgca gactgatgac 311940 aatagtattt gaaatgctcg tagatctgct tctaggttga tggaaagaat gtatgttcca 312000 aggtacaagt gcttgttgac ttttcggatg cagccagtct gtgctctttg tcaggtaact 312060 cggaatcact ccacagtagc tgtccttcct gtccatttga caagcactta aaagggcagt 312120 cttaagtact ttacttcata gtttattaat tttttccctt ctttagtttg caatctactc 312180 tcagaaactg aaaaataatt tcttttacct ttttcccctt tctcatttaa gctgaaattg 312240 atttctttct gagcgtgtaa ggaaaaaaat aaaaagaagc tgtggttaat acaattgcct 312300 ttgctgaaca aaaataaaag actagtttac cttcaagctg tgctgtatca gagtaaggat 312360 ctgttctgtc actcccagga gattttgata agagagagta caaaatttca taatatctac 312420 atagcataat tgtagcaaat ataagaagta ttataattgt ttatttgggg atgagggtgg 312480 ggatgggttt ttttgtgtgt gtttggaaaa ttgggaagct agaagatact cttaaatcca 312540 tcagcttctt cagaactctt ctcaaatgct tattgtcatg acaaccatct cttcataaac 312600 caaggctctg agtgtaatac agatggggct ggtaacaagg taggattgcc atctgctttg 312660 ttttctctaa gggacattat ttttttgtga tccccaagtc tcatcctcaa atctgaaagt 312720 cttgacttat ttttctttct ggagtcagat agagctgtga gattaattct tttctcctga 312780 caaactactt cctcacctgt catcaaacaa cttacttgtt aaatggaggg aaaaaagggt 312840 aattatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaaa acaaatatac atattttaat 312900 gatttattta tctgtctact ttgcaaagtc tcctatgagg tacctagtaa ttcaataata 312960 cagtcaagtg tgagatccag aaacaagtag gagtgaggca atcattttcc catgaaacaa 313020 gtaaaattat tactgctttt gaacatttta acacctgtgc ttcctgatgg tggggctgca 313080 tgaagtttgt aagtagtgtc atcattctct tattaggtaa caaataggag cataattatt 313140 taggagagga aaaccttttc ttgttaccaa atttggtgag aaatttgcca aagaaatgaa 313200 tgcttacagg agggatacag cttaatatct tcatactccc ctttgtcaaa gatacaagtg 313260 acattttctc atatcaactt cctacaaaaa gtgaggccat acatttttaa aaagaatata 313320 cccagtattt taaaagtttg tatatatcgt gatcagaatt aagatatatc cagcttttga 313380 aaaaatatac atatttagcc attaaaaggt atgtggtaaa ctaaactgat gaataaaggt 313440 tatgggaaat atttcataaa atttatattt aaagtaaaga acaatttctc tctttgtatt 313500 atagttattt tacataagct acaatctata attctaaacc ttaatttctt gaagggcttt 313560 ataagcctca tttttctttc taaatagaga agttcataca ctgcttttat gtcctatatg 313620 ttgatgtgta aaaataatca aatactagtg ggtgagtaga atgtaactac aatatggtac 313680 acacacagac acacaggatg actaaactgt gcacatgagc tgatgtccag agcagggaaa 313740 agctgctaaa gaatgtttga agtagagtca gaatgcagtt ttgtggttaa gaccaataat 313800 ttttcaaagg agcattataa ggagtgtggt tacttgggtt ggagttgaaa accaagcaac 313860 agttgggcag acttgaaacc agttttgtct ttaggtttct tttcttaatg attggtctac 313920 aatgagttag ccactcatcg tatttaaggt cttggtaaag gagagacttt ctttgccatg 313980 tagtttatac ctcatgtatg cattacagta gagagctcca ggaaatactg caggccttct 314040 actggttttt atcctctatt tagataaaaa tgaggaagaa gtagaattat cataaacaat 314100 cctgttggct tttagttgag atatactaca gaaacatcac ctttgaatct gtatatgtaa 314160 aaaaaaaaaa tctcagagta agatataagt tctgttgcat tgttctgaag gaatgggtaa 314220 tgtcagaaat gtcttcatta cattacataa agtaatacac agtgctgtta tcagattgca 314280 tagtcaaagt tggcaagttt gcatatttac atagatatca tgaccttcat cattcatact 314340 tctttcaaga aatggtcatc ttaatatggg gtatttattt gaggcataca ccatttattt 314400 taagaagcag tacctttgtt tattgtaaaa cttctggact aaattcttca attttttctc 314460 aaatgaattc agttttttgt tttttttctt accactggtt tttactgcat agcgtttgcc 314520 tgaagaacac cactttgttt cccaaggcaa gtagtcacta caaggcgagt tttgttctgt 314580 ctatcccaag gcaaatagac agcagcaaac atagtgtgga gggctgctgg gttcagtaga 314640 aaaccatcaa ctatttctaa ttgggggtgt atgaagacag ctgcattctg gacatgctaa 314700 acatcttgaa atgcttggag tgtaataaaa ccccaaacgt gctttctttt ctcatttctt 314760 tgcacatgta ttttaggcaa aatataatcc acatgctgtt gttccctctc cttttaaatc 314820 atgaaaaatg ttgtttttat agggctattt gaggtccagg atgccttttt atccttttta 314880 ttaggttatt tttatatata aatgaaaaga aaaacataaa cagaaaatac aacatgacat 314940 catgaatgag ggcaagcaca aactgcccaa tttaagtttg aagttataaa cctaaaatat 315000 tttaaaacaa aacatttctc ttggtgtttt gcaaaagtaa tgctttcttc tattgggcag 315060 aaattgcagc ctgttgggat gaaggagaga atagaactaa tatttattga gtagctacca 315120 tggctttctg ggacatctgc taacccctta atttttacag taaccctaag tggtaggcca 315180 gtccatctgc attttacaga caggaaatgc tttcagagat attaattaga tggctgtaga 315240 ccacagaaga attgaaagtc aggtcttctt gacttttcag ctcatgactt cattacttct 315300 gccctcctca ttctgttggg agatgggtgg gagtgtgccc tccagataat cagaaagtcc 315360 catgttggga tgtgatttgg aaatagctag tcctcaggcc tgtggacgaa ggctattgta 315420 gcctcaagaa agaaagagtc agcttgatat tggcaaggtg gttatttagt gtggcagctg 315480 cataagagca ttggataggt ggtatgatat gggatggggg tcagggtgag agctgctcac 315540 acctccttat tatggcaggg caaaaccaga atagtcacag tgatggtgat gtagggtagg 315600 ttcaagagaa agctcatgtt cttctagcat tgagactcac aatatttcaa aacaagtgat 315660 tatttattcc attactattt attttggtga tggatgttgc atttatttta ttttctaaca 315720 gtagtacata tttggtaaga gttgtttgtg acattcttta tttaaatgga ttaaacccat 315780 tttcttaatt tttttaagtg tttgtcctgt tatcgaagat atcttaaagt gttacagaat 315840 gggaatcata gctttaatga gtctgcatat aagagagtcc aaacattttt tttttggaga 315900 gaaggaaggt catttcaact gtactatagg aacgataggg cccatgatcc atggtatggc 315960 aataagttac tattttttgg agaataaatc gcaaaatatg ggacgtgaag actgcttggt 316020 atttacacag gagtctagtt cttctgatac tatatattct ataagctttc tcccagaaat 316080 ccaaagtttt atttagcttg tagccatcat tgtgccacaa tcttccttcc atgatttatt 316140 tttttcccat actgtactct tgcactgagt ctttggcatt gaaagggaaa gagatgaatt 316200 attcaactct tcttctattg agtgaaaagc caatacagaa aaaaaaatgc aacaggcaat 316260 ttcatgactg acattttgga gaacattggg gtcatcatat gactgagaaa atgattatct 316320 cttttgaagg tcaggaaacc aatatttttt tttccagtga atctactgag ggaaccaacc 316380 acctagcttt ttgtaaatag cactcctcag ggaaatgttg cttttttctt ttgcagtgtt 316440 tctgctttga atcttcatag actgtatccc atggaagcag gaatataatt actgtagtgc 316500 ttactttttt tcatgtctct actgaagagc caccctgatt tatcttttac tccaaggtag 316560 tgtggaactt tacaaggatt tagattatat tagtcatttt gcttggagat ctctgcacac 316620 ttttcaacat catttctaag agccttgcca cactcagtaa aagagggtga ggcttcaaga 316680 atctctgtgt accaacgcaa attaggcaat ttgtaagaag tccctagtag agcagagtgg 316740 agagagggct caggatctcg tgaggcctgg ggcagggagg tggacatgct atgagctcct 316800 ttcacagtca acacaaagtt aacacatctt ggaggaaaaa ccgttactgt ataatggaag 316860 gcagaaggca gggatgtctg tgcttggtga tgaagctata agtagtgagc tgatttatga 316920 tggaggggtg aattgtgcca tgaaagagac tcccctcaat tttattagcc agattactgc 316980 ccatatgcgg ggtgaggagt gagcatttta aggcatttct ctctgttttc aatatatcat 317040 ctctggattc actattactg ggacttgtga atatagacta gggattaaaa cctgagtttg 317100 cttttaaaaa actttatttt attaaatgag atttctgagc aactgatttc acttagtctt 317160 atcaaactat tcttactact ttttcgatat gcattctgtc cctcctgtgt gaaggccaca 317220 ggcccatggc ccccatgtca ttgagatgga ggtcctcaag tgatggcggg atgaatcacc 317280 tctcacttgc cacctgcgag aatgtctatc actgatacct ctccttatgt cccgtagcag 317340 ctgctaagct cccacgttat tattggtgac actttctagt gttcaggaga gaacaggatt 317400 tactttttga atgcctctaa attattatag caggttcatt tggaattgca tatcagaaca 317460 ttcttcctgt ttatcaggaa aataaaccaa ggtcttgaaa cttgatgtct atccatagtt 317520 ggcccaatat aattttgcat gtggtttatt acattatttt tctccattgg ctatgaactg 317580 aaggcatctc atggatattt attccacgct gaaaaggtag ttagatgctg tgtggtaaag 317640 tcgagaccag tatattggaa gaaaagagac actccatcta ataatctttc atagtcttca 317700 cattcattga gaaggttact tgataacctt tcctgcacac tctctcccaa ccctgaccca 317760 ggaacttgca gagcacactg tgcaacagat ctaataaccc ttgtctgcag gcaatatgca 317820 cagctgggaa agataattaa atagactctt tttgagaggt ctacaacatt tcaacggaag 317880 gatcgagcaa tccggctggc ctccgactga aaactattac caacagacat acttcagaca 317940 gattccatga tcaccatcct tatgtggcac aagtgcttat ggggagcttc tttggcttcc 318000 aaaaggccac taaaactgtc agacctaaat aatactggaa ctgtaaagtg ggaattaaaa 318060 attataattc catttaacat gtaacgttct catcagaaag gggcctttgg ttttccatat 318120 tgatcggtta catggtcagc tgcaattgta actcatgaga cacacccaga tatcatcctg 318180 cgtgattctt tttgaggttt atttagggtg ttagataatc cgaggtaggt ttcatcatgg 318240 gtggcaatat tacatatagc aaatgtcatg agaagagaga caaagcctcc cttttgaatg 318300 ttaacattta tgcaataagt ttaatgtacc gtgtaagttt acattactat tatgagactt 318360 aacctaaaaa attggggtga aatcttaaag aattatgaaa ttaagaaatg aaaccagagg 318420 gctttcgttt taagtactga tcacttaaac caaaaccagt ttggcttatc ctatgagatc 318480 gtgggtattg agaaagagga acatttgctg ctgcatccgg agatgtttcc ttgagagcaa 318540 gactagttcc ttttgaccca gtacatccta caggtaaatc actgcatgct gtagagatac 318600 ctgttccctc ccttccccca ccccctgggg atctgaaacc aaatcattgc tttttcatct 318660 tttacttatc cttataaaca aagccaccca ctttctcatt tttcctgatg ccaagtcctt 318720 ctttacatga gtggaatcca ctcttttcaa tggaaagaca cctgctctga gacaggctac 318780 actgtcatga gccttggcat ggctgagtga tgtagtggaa ggtgcaataa atttaaactt 318840 taaaaatgca aaatttgatg gaatcatgca tcttgtgcct acagtgagta tatggtctag 318900 caggatttac agatacatgc atgattaatt tgaatacagt atagcaaaat gatctgttaa 318960 aaaacacatg aaaagatgtg caaccttatt agtcattagg aaaatgcaca taaaaccacc 319020 gttcctgtgt gatacctctg tacgtctatt agaatgtata aaatttaaaa agactgaaca 319080 tagcaagcac tggtgaggtt gtagaccaac tggtgctttc atgttttgct ggtgagaatg 319140 taaacattac aactactttg aaaacagttt gacagtttct taaaaagcta aaacatccac 319200 ctggcatgct atatacagat atcctactct tacgtattta accaagagaa ataaaagcat 319260 atatccattc aaaaacttgt aaataaattg ctcctagcag ctttatttgt aatagccaaa 319320 aactagaaac aacccaaatg tccaatgaaa ggatacatcg tatttattta taggacatat 319380 ccatgcaatg gaataccact taggaataga aagaatcaac tgttcatcat acatacaacc 319440 acatggctaa gtcttaaaaa taattatgct tagttaagaa gtcagacaaa aaggtaagag 319500 actgttagga gctgaattag cgggttaaca gtggcaatga aaaaggagaa aattatagct 319560 acctcaagat agaattgatg agctttgatt atgaaatgat ggtaagagag agggccatag 319620 actctgaggt ctgtctctag ctttggtttc cctatgtgga tcattatcta tttggatata 319680 agaattatct gaaagatgat acttaagcat gtaagaaatg ataagctacc tgtttaatga 319740 tgagcttttg ttacctccaa gaaccccaag aagaaacatc ctgtaagcag accattcata 319800 cttgattgtt aaaggaaaac aaaattccat tttgtctttt tcatcaacac aagtatagct 319860 ggctaataaa agtgtaatat tcatgagaga aaaagaaaag aacacgcaca cacatacact 319920 caacaggatt cctagagtca ttcccatgga taagagggaa ggaaaggttg agggcaaaga 319980 gagaagggaa ggaaacagac tatgatggga tatcttaggg caaaagaata gggggctgat 320040 ttggaaggca gcaaacttca tggatacttg atttatttaa tgtccctgtc actctggcgt 320100 atcttaatgt gtgtggtgtg tgatttattt agtcacttga tccaaattct ctaattaagt 320160 ggagctcaga agatatagtg tccattgtgg tcaagggcac aggttttggc ttcaacagac 320220 aaataagctc tctgagcatc tgtcttctca tctgtacaat gggaatatca gttcctacct 320280 cttcaggttg ttgtattcat aaataaattg tgtacaagaa acattaggat tgcttcttac 320340 ccgtagtaag ggctcaacaa accttctcct ccttctcctc ctccttctcc ttcttcttct 320400 tcctcctcct cctcttcttc ttccttttgc ttttctcctt ccttcttcct tcctttcttc 320460 ctacctcctt ctcattattg ttattaggta accacaatat tatcagtaat gattggagaa 320520 agctttaatc tcctagttca ccattagaaa acaagaacac attttggtgg ttattacccg 320580 aagtaatcat aatgtcacct ttttttccat ctgactcatt atcccaagtg atttatttat 320640 atatggagtt ttctgagtct ttcttttaca tattacaaaa aaagagtgtg atttagggac 320700 gaagcaaaga aataaaaatt tagtgacttt cattctgcct gtgccccaat tcctattggg 320760 cataaggcaa gtaatttaaa tttcttagca ccttagcatc ttctactcaa acagaaatga 320820 ggaacagtca caggttacta ttatagctgt ctaagtagaa ggcacacaag ttttcacact 320880 gagtataaca ctttatagaa agctaagtgt gttgctcaag ttggtacatt tctgtagatg 320940 tgacactatg gcactaagaa acttaatgcc acattgaaat tcattgagat agctagactt 321000 taaaaataat tacttgactt cactataaag tatgttcgta ttgcatttac tccatctagt 321060 agaaaataga ccttgtcagt tcaaatccct gttgcattaa tttcaccagt aatgagtctt 321120 tttcatttga gtcagcaggg tttttcttgc ttgttttcag gctttgtgga tttgaccctc 321180 catgatcagg tccaccttct agaatgtgcc tggctagaga tcctgatgat tggtctcgtc 321240 tggcgctcca tggagcaccc agggaagcta ctgtttgctc ctaacttgct cttggacagg 321300 taagtgacct ggctgtagct taggagtagc atgttcttta cgatcatagt tcattcatga 321360 aactatttta ttcatctctc ggtgaagctt cagagaactt tattaggtat gtttacttaa 321420 caaaagagtg cattgggggt gatgaagcct agtcaaattc acagaaagct aaggataact 321480 ttctgctaga cattacctca gaagaattct attatttcta atacacacac acacacacac 321540 acacacacac actcacactc tctctctctc tctctctgtc attatgaatg gtaattttct 321600 aactccatct tcaacttgta tcatataaaa attataataa cctctcttta attaaaatct 321660 gttgttgctt cttgtacatc cataccacaa tagcctattc attttcttct ccaattttcc 321720 catccgtaaa atgaagaaat ttgaccagag ttctgaaggt cacattcagg tcgacaaatt 321780 cattttcatg ttcaaatatg ttaccttctt taacatacca ttctggggtt gccttggaat 321840 gtgggtccca ttgttttttt tttttcagtc attgcttaga gtcatagaat ttagatatta 321900 ctcaatagca gctgccactg atagagtctc caccctgcac cagctgtgat gctaaacact 321960 ttacatatat tatctcattt aatcatcacc ggactcctag gaggcaggaa tgtcatcatc 322020 catgttttac cagaaaggaa actaaatctc agagacatcc tgctacttgc aaaaagagga 322080 aagctcacta aatggtggag ccagagttca aattcaagat ctttctggct ccggtatgct 322140 ctgttacctc ctgtgctggg cacatggtct tcccactctc atgttcagtg atgcctcctt 322200 tggtctgctg ccatagcatt ctgttttcca ggtaaatctt gtctttgtgg gctacataac 322260 attttggatg agaaagaacc attttgttgt ttcttgcaat cctattttgc ctccgtgcca 322320 agcagtctaa ggctgccagg ctgcccacag tgcatctctg catggtactt tacttcagag 322380 catttcacta tctttctaca cctgccaagt gcctggagca gagttgcagc aaaatttatt 322440 taagtactgg agaattgtac aaggtgttgg ttattgtttt gtcattttgt gttaacacag 322500 cttttgaaaa acagtggtga tacagtttaa gaagcatatt ttgctgtctg tggaatatat 322560 tttgatatca cagtttcaca aaattatcaa gaatggccac tagtcttgtt ccttagaact 322620 gtactcacaa tgtattctgt cagccttata gaggatgtct ttaccgtgtt ctttcctttc 322680 cattccttgt ttcctttcca ttttttccta tctcatttct cctctctttt cctttgcttt 322740 cctctttctt tctttctcct gtcctcttaa tttttttgtc ttatagcagt gtggttttgt 322800 aaccaagtga tatcaagttt gcaaatgaaa atcttagacc acacgtaaca tttccctgcc 322860 tactgcctgg agtgtctacc atgtttaggt ttttggacat tcataactca tttgctcctt 322920 gatttccatc ctcatctgta tctatcttct tttttaaaat ttaattcaat ttttataatg 322980 ttgacacaat tatgcagatt catagggtac acagtgatgt tttgatacat ataatgtgtg 323040 gtgatcttat ctatcttctt gagtacacac ttgcttgagg acagtcatca aataattgca 323100 ttttgaatat gtgaaggttt ttgacattac tgcacccaaa aaactcatat tgccagtgag 323160 gtgatatggc ctaggatttt atcagctaca gccttctctt tcctttctgt acactccagt 323220 ggtggctaat tttctttcct ctctcacaga agtatgaatg actaaaagtt ctcatctcta 323280 ttcattccta ctttctaaaa cttcagatcg gaaatttgaa ttacctctag accaggattt 323340 gtcagtctct ttactattga cattttgggt cagatcattc tttcattctt tcttggttga 323400 ggggttgata ttgtttggtg tgtcctcatc caaatctcaa attatagctc ccatagttcc 323460 catgtgtcat gggagggacc cggtgggagg taactgaaac ataagcaaag gtctttccct 323520 tgctcctctc atgacagtga atttctcatg atatctaatg gttttataaa ggggagttcc 323580 cctgcacacg ctctctctct tccccgttgc catgaaagat gtgactttgc tccttcttcc 323640 ccatgattgt gaggcttccc cagtcacaag gaactgtgag tccattaaac ctttttcttt 323700 gtaaattacc cagtctcagg taggtcttta ttagcagctt gagaacagac taatacaagg 323760 ggctgtcttg tgcattttag gatgtttaac agcatccctg gactccacca gctagctgcc 323820 agtagcaacc tccacttcct ccagttacga taactaacaa tgtctccgga catttctacc 323880 tatcttctgt tgtgtcaggg ggtgggggag gtaaaattgc ctctggttga gaatcaccac 323940 tctatgcttt cccaactcaa tgttctataa gctcctcaga cacactgtac tctaaactgc 324000 acactcactt tatcttctgc aacaagtcta ttccttttct tttctgtctt ggtgacatca 324060 acactcacct agacactaaa gctagaagct ttaagttacc catggattct accttctccc 324120 tcaccaaatt atccagttaa ctatcaagtc atctatgaac tgcttctgaa tccagacctc 324180 ccctctatcc ccattcctct gcatggcaca ggtcctggtt gtctctgctg cagattcctt 324240 gcttctgcac cactgactca ctttcttggt cctgctactc tttctttcag tccatctccc 324300 atactgctgc tggagaaggc tttctaaggc acagctgtga tcatgatgct tcctgactca 324360 cctttcagtg gctctctcaa ttcttaacat ggagaaaccc catctctact aaaaatacaa 324420 agttagccgg gcatggtggc tcatgcctgt aatcccagct acccgagagg ctgaggcagg 324480 agaatcgctt gaacatggga ggcagacgtt gcagtgagcc aaaattgtgc cattgcactc 324540 cagcctggat gaaattccgt ctcaaaaaaa gaaaagaaaa tactgtgtag acttcttatc 324600 ttaataatca tgaatcacta ttacaagtgt ctcaaacgca aatttctgaa gagtcacagg 324660 tgacccagtg agcccttgtc caggctaaaa acacctggtg gctgaattct gaacttcaca 324720 cattcgaatt tctcttccat tgcttctgag agaccctcca ccattacggt tccttatcag 324780 agtcatatct acctataagg ctcatttcag gtgccgtctt tttataaaat cttccttcaa 324840 actttctcct cttcagcctt tatatataca aaaggctttt ctttcttttc cttttctaag 324900 tttccattgt agttggtttg cttttctctt tattattctc attccaccat attagttatg 324960 attggatgtc ttcttacctt ccctactagc tcataaactt cttgtggtca aaaaccagat 325020 cttgttcgtc ttgtgtgatc tccagtttac gaagtcttcc atgataccca acaaatattt 325080 gttaattgca ctggccaagg tcacccaggt ggcttgtggc caaatcagaa gaatctacat 325140 cttctgatag tcatggcagc tgttattccc atccaactca cttcctgtgc attgctactc 325200 atcaattccc cacttattct tttaaaaaca ttgcataaat acatatctat gtgttttgga 325260 aagattttct taatctataa gcgcatttgg cgtgtgctta tatgtctgct tatatgccaa 325320 atttgaaatt ccaaatttcg ccatttggaa tttcaaatgg ggaaaagcaa agactcttat 325380 ctttcccata atcaaacccc ttatgaagta aaatccttaa ggtctctcta caggttaaaa 325440 ataattaggt gatatgattt ggctgtgttc ccacccaaat ttcaccttta attgtaataa 325500 tccccaggtg tcaagggtgg ggccaggtgg agataattga atcatgtggg ttgttttccc 325560 catactgtta gtgtggtagt gaataagttt catgagatct gatgatttta taaatgggag 325620 tccccctgca caagctctct tgcctgctgc catgtaagat gtgactttgc tcctccttgc 325680 cttccgccat gattatgagg cctcctcagc catgtggaac tctgagtcaa ttaaacctct 325740 ttcttttata tattacccag tctcaagtat gtctttatta gcagcatgag aacaaactaa 325800 tacattaggt atatgttaat gatgaggaat gtgtataaat acatatacat ttatatttaa 325860 atattaatat ttacaaataa catgatatta aaaatatggt ctataatttt ttaaattatc 325920 tacctttcta atcattaaca tgcactaaat attattaaat ttcaatatta tttaattacc 325980 atcttggtgt ttgaggataa ctgcttttga tggcattgat agatgcatta acagtgaaac 326040 attgtgacca acagcccatc tgagatttta tacttgtaga agatggcttc tgagtgacag 326100 ctgagaagac tgtttatgtc tttgccctac aggttcctaa cccctttaat aaaatagagc 326160 tctctgatgc agatgacaca tgggccttct ttttgctctt gtcccatcac attgtacata 326220 gtaaacattt ttagcaacaa atagtagata cttataactt taaaagctaa gtggttgaca 326280 gctgagaggc agatgatggt aatttcatca tttttctcat atctcaggca ttgtgacact 326340 acctctgcaa ggtcaactgt ctccataggc tgttttcatt tgcgtagaaa taggggggaa 326400 agatagcttg aagtcatcag gagccctgca acccatggat taccaatgtt gctaactgga 326460 gcctggattt catcttcaat tgattgtaat gatgtcttgt tctctcaaat ctttgcaaat 326520 ctaggcattt ataagactat cctgtaggtc ccttacaaga ccatgaggat gctagaactt 326580 accctagtct tttcttgtaa ttgcttaaat gttagtattg gcaaatgggg tttggtgatt 326640 ataagagtaa aaaaacctgc tgccatccca catttgtgag cagaggatac atttcctatc 326700 ttgtgtccat ttaaaaagaa tgattgcttg attggcttcc tgatgacaac ccatgatata 326760 ctgattctgt tagtttataa ctttcctagt agtcatatgc ttataggcca attttatcct 326820 tgccatgctt agcctagtca caatttccag ttcttctctg tatcctgcag cagtgagttc 326880 caaacactta atgctgtcat ctcttcctgt gaaaaccaag aaataaaggt tattataagg 326940 tataaataaa gaacccagtg atttctcttg gggtgtgtgt gtccatgtgt gtgtatattt 327000 tacaagagga aagttaaaga tactaagaat gcctgtgaaa gtaatcagga aatggagaaa 327060 acttgttttc cattctagca cctaatcctt tggtgtgttt tggcactaga aaacacaaaa 327120 tatgtcctct gtgtctacta ggaatgcctc tcttcattta gtcctgcttg agtgctcatg 327180 atggaaaaat atagactgaa aacaggagca aaagtgttca tcctactcat tccttgtggg 327240 gtctctttgc tttcaaagag atgttagaga tgttagtaaa tggtgttaga agaaacaatg 327300 taaattgcct gtttagtaag atgatccagt ttctaaggaa ctgttttact ggcgccttcc 327360 atgctaacaa attctgagaa atatttgcgg atttctcagt gaagccaaag cactctcttt 327420 tgactcctat ttactctcag agaaaaaaac tattcatcca tttgaaaagc agggaccaat 327480 tcaacaagca gaatattccc tctactaagc ctttggccag agagttgttg ctctagttct 327540 ttccatcact cctgcatcag gaggctctgc ctgcaggaaa tagtattgga caacagaaag 327600 ttcttttact tgtaggcata aaataggtat aaattctcct ccttaagaga aaaacaggtt 327660 gctgcaccag aaagaacatt tgcctcttct actaaatagc agactgtttt ccaatgataa 327720 actcatttta aatagaaaaa aaaaagtcat tctctacaaa caagaacatt ttcattttag 327780 gttgtttatt gtaaatattt cagaaaaaaa atatgcaaaa aaaaaaatgc ccaaaaatca 327840 atgcttccag taacatattt attagctatc tttttcccca tgtaaaactt caggtaaatt 327900 ctttgcagat tttttacttg gaagaatgat aaaaaaaaaa aaaaaagttc tgaaatgagt 327960 tgaattcatc cacgtgtgtt tttgattcac atgaagagta ggacctccct ttatattccc 328020 tcttcaaatt ctcccctctg aaaaatgggt ggtacactca aaggaggacc gcacacattg 328080 tagtagctgg ggtgttgggg gtggaaggag caggttttgg gggtgggagg agcggtgagt 328140 gatcctttca gcaaagtcag tcctgggcag gagacggctt caggaatact gtcagcttta 328200 ctggattcca ccatcgcttt ccaggactgt ttaggccctg ggcccttgaa gggtttgcgt 328260 gcctcttgtc tccattcata cctcaagaac tttgttcatg ttaatttttt ttcactctat 328320 catatggaat tgagtaaaaa aagaaaaaaa aaaggaagcc aacacttact taactgcttt 328380 aatgtatagg actctgttct gggttgtctt ctaaagtaca tttcattcaa tgtgtgagaa 328440 tacagatagg aaagagtttt gctagtttct attttgactg tggatccatt gattctttct 328500 ggttctcagc ccttaattgc tcagctgcag ataccacttg actgactctt aaaagtcttt 328560 ggtttattgc ccaattctgg gaatatgaaa ctgtaagctg tttaggagaa aaactgagac 328620 caaaagaaag gagaagtgag ccaaactgcc attatgattg ccacttctta ttgaagataa 328680 atcaaaatat ccatttgact agaaatcaat tgaattatgc actttaaatg ggccaattca 328740 atgatacctg aactatatct caaaaaaggt gttaaacaca ggcacacacg tacacacaca 328800 tattggaatt ccaggaaaag tcactttgat caacaagatt atcagtcgtc aaagtgcttg 328860 gaagggttct attggaataa agctaaaaaa aatcaaagta aaatttctcc ttaaaaacaa 328920 aagcaattaa gcagcactgt attataaaat atgctaagct gcaagtcaaa attcttaaga 328980 gacttaagcc tgtaagcagt aaggatccac tcaatgtaaa gttactccag agggaaaggc 329040 gtgagcccaa ccaaagtatt aatgctgtgt aggaggttaa tttgactctt cttaacattt 329100 ttacacacca cattatgttt tattcaccat ttattattaa ctgaatttat taaagtataa 329160 tcaaaataat atttttgaga gtttaaaaat attctcataa tatttaagtt acatatacta 329220 tgcagggacc gtcaagtaat tccactctga catctgtatt tattaccgcc acctgtccat 329280 gatggtatta gaaagatcct catttgtttt aatggatgcc tctaaaatcc agttttaaga 329340 gggggttggc cactttcaag tttgtgttag ttaggattca gtttaaccca gctcaacagg 329400 tatttactaa gtaccagcat atccataggg cgctgtatga tactggagga cacacagaaa 329460 agagatgtgt aagaggcact cctgccctca aggagtttac tattgagtgg tagtgtaata 329520 tgaataaaca aatgaatctg ctcaaaagca gggcattcta agcaggccct caccagcctc 329580 tcatcattcg catctagtgt atcttcctcc atcactttct aaacgctatg gattctgagt 329640 gaaaaccaat cgctggttta tgcatgtatg catatatgaa ttcattcttg acattgccat 329700 gcagagtatt tagtataact agacttatta tccatttatc ctgcctagaa gcatactgta 329760 atatatataa ctctaaaagc aagatcattc cttatgttgg ttcttttgag ctggcagggg 329820 gaaagcagag tatgttggca ggggtctatc aaggtagatg agcccagttt gtacatcttt 329880 gaaatattac caatgccaat gtgttagtac tgcttggatc tcttctatga caacagttct 329940 tattttttcc ttttttttgt ttgtttgttt tttgagacag gatcttgctc tgtcacctag 330000 acaggagcgc agtggtgtga tctcggctca cttcaatttc cgcctcctgg gttcaagcaa 330060 ttcttgtgcc tcagcctaca gagtagttgg gattacacgc atgcgccatc atgcctggct 330120 aatttttgca tttttagtag agatggggtt ttgccacgtt ggccaggctg gtctggaact 330180 cctggcctca agtgatctac ccgccttggc ctcccaaatt gctgggatta caggtgtgag 330240 ccaccacacc tggcccatca gttcttaatt tgatgaatgg atagaggttt ggcttcaaat 330300 aaatggagtt agtctgtcaa tatctgtttc ttttaaaatt tgcaattgtt tttattttta 330360 gtgtcatgct atgtgccctt aatgatctag aattaagttc taatctctac cctggtataa 330420 ttgatttctc cctgtggact cctaatataa gaagaaagat gaagtttttc ttttaatgct 330480 tttagagatc ttcattaagt catttaatat tcttatttgc tatttcccag tgtgatggtt 330540 aagactgagt gtcaacttga ttggattgaa ggatacaaag tattaatcct gggtgtgtct 330600 gtgagggtgt taccaaagga gattaatatt tgagtcagtg ggctgtggaa ggcacaccca 330660 cccttaatct ggtgggcacg atctagtcag ctgccagcga atataaggca ggcagaaaaa 330720 cgtgaaaggg gaaactggcc tagcctccca gcctacatct ttctaccatg ctgaatgctt 330780 cctgcccttg agcattggac tccaaaatat tcagttttgg gactcggact ggctctcctt 330840 gctgctcagc ttgcagacag tctattgtgg gaccttccga tcatgtaagt taatgcttaa 330900 taaactcccc tttatatata tcctattagt tctgtccctc tagagaaccc tgactaatac 330960 acccagtgtg ttcttttatc aaatagaaag gagatataga aaacacactg tccatgtctt 331020 tgattgttac accacagcag agaatcaatt tcttaacctg cttacttatt taccattctc 331080 caatggtgcc aattctgaga tccatcatga ctttatcatt agaaaagggg atgtaacaaa 331140 catgatgaga tgttacggga atactgctta ctgcatgata tggtttggct gtgtcctcac 331200 ccaaatctca tcctgaattt tagcctccca tacttcccac gtgttgtggg agggacccgg 331260 tgggaggtaa ttgactcatg ggggtggttt ctcccatact cttctcctgg tagtgaataa 331320 gtctcacaag atctgatggt tttataaggg gttttccctt tcacttggct ctcattctct 331380 cttgcctgct gccatgcaag acatcccttt gctcctcctt catcttctgc catgattgtg 331440 aggcctcccc agccatgtgg aactgtaagt cctttaaacc tcttttcttt ataaattgcc 331500 cagtctcatg tatgtcttta tcagcagcat gaaaacggac taatacactg catgctcagt 331560 atactcaggc actctggaaa ctaggtttct acttcggacc cctgagagaa aagggttatg 331620 tatctccaag tgtggtcatg acaagcatca ctactgtgtg cagttgggcc tgtggattga 331680 gccaccttag cctctgagga aagcagaacc tgagagcatg cttaattcag agtgtgtgtg 331740 acttggagtg tggaaaggaa gatttccaga tttgcggtat tggcgactga aaggatggca 331800 atgctattga tggagattag gaagacagga gagaggtaga tgttgagcaa ctccgaggag 331860 tttttcctca tacatgttgg gtttaaagtg cagggaagat atcctgaagg ttattccagg 331920 cagaaatttg gagctcagaa gagacatcag agctgaagat aaaaaatttg agagccatct 331980 ccgtagctaa aagtgtggaa cgaatgtgat gactagacaa gataatagag aaaaggtatc 332040 caaaggcctg aggtcaagac ctcttaaaag gctgactttt cagggtttta ggtagaaaaa 332100 gagtcccagc ctggggttaa ggcagttttt tgagaagtag aggtacaaag ttccttgttc 332160 caaaggaagg gtgtctttca aaagaaaaag gatgggccgg gtgcagtggc ttacgcatgt 332220 aatctcagca ctttgggagg ccgaggctgg cagatcacct gaggttggga gttcgagacc 332280 aacctgacca acatggagaa accctgtctc tactaaaaat aaaaattaaa aattagccgg 332340 gcttggtggt gcatgcctgt aatcccagct actcaggagg ctgaggcagg agaatcactt 332400 gaacctggga ggcagaggtt gcagtgagcc aagttctcac cattgcactc cagcctgggc 332460 aacaagagtg aaactctgtc tcaaaaaaaa aaaaaagaga gaaaaagaaa aaggatggtg 332520 aattgggcca aataccagag agatggacag gagtaagaag aaaaagacta aagatttgtt 332580 catcaggagc tcattgtttc taaagggagc atttttagta aagaggaagg aggaataaaa 332640 tgcagtataa tatgttaaat ctaagtataa tttataaaag agaaaatggg ggtggaatat 332700 tacaaaaaag gaactataaa ccagctcttt gaggtatttg tcagtgagga aaacagtggg 332760 gctctagttc ttgatagcaa cagcatcaaa gggaactttt taaactaaaa tattatgaat 332820 ttttcaaact gaaataatga gagaataata caaagaaatc tcatctgccc ataatccaaa 332880 ttcagtagtt attaaaattt tgccccattg cttaatccat taatctcatt tcattttgtc 332940 ctttttcttt gtttattttt ggctaaaaca ttttaaagac aaatcctaaa tatcatacat 333000 cagtaggcat ttacaaaaaa atttcttgat aatcacaatg ccattctcat accaaataaa 333060 cttataataa ttctgtgata tcatctaaaa aacagttctt ttctacatca aaaatgtctg 333120 tttatagttg atttattcaa tttagagtcc aaacaagttc catatattag acattaggtc 333180 attaatgtct gtctatttga atttataaca atttccactt aatttatttt ctccagcttc 333240 tgtggagact aggtaagttg ttttgtagct gtctggatat atctgattgc ttccttgcag 333300 tgtcatttaa cttgttcctc tatcctcagt gtttctgcac atggaagtta gcctcatagc 333360 aggggttggc atactttagc ctgcttacca aatacgactc ccttacattt ttgtaaataa 333420 aatgttactg gaacactgtc acatatgttg gggtcataga aagagtttcc gtgtccccaa 333480 gttataattg cattcactta tattttcttc tagtaatttt tacccttaca tgttaggggt 333540 caatttggaa tttctcttca tatacagtat gcaataaaga atggctttta tatttttcca 333600 aatgtatatt cagttgtctc aacaccattt attaaaaagt cagtatttct caagtgattt 333660 gagatctacc cttaattaca cagtaaattt ctctgtagtc ttgtcttttt ctaatatgtt 333720 aattctgtac caagatttgt tcatctgtta atggatcaat atcacatagc tttgtttata 333780 gaaggtgcac attgttttaa ttctggccat gctatcccac caaatattgc cctttgattt 333840 ttcagagttt tactgtggat tcttccttgt ttctttttct atgtgacctt tagaattaac 333900 ttgtttaatt ctataagtaa atttattgat aattttattg aaattatgta aaatataaat 333960 tggcttagga agtactgata tctccatgac attaagtctt catatctaag accaaggggt 334020 gccttttcat ttgttaaata ttctttgtgt ctttcagaag tgttttcaag tatccttatg 334080 tgtattttgc acaaattttt atatttgtgc ctattggatg ccacgtgcag ggttaaaaaa 334140 tattatacct attttatata gatatatatg tatataaaaa tatatattat atatagttat 334200 aatacataaa tatattttaa tatattatat aatatataca tgtattgtat ttatatatgt 334260 atttatatgt gtatctataa atatacatat gtatgtatct ataaatatac atatatgtgt 334320 acatatacac atatatacac attatatgta tgtttataca catataaata catatataaa 334380 tatactagaa agtccatggg gtttcctagt atacaatcat attgtctgca aatagagatt 334440 gttatacctt ttcctttcta ttccaaagtg tctaaaagat tttttcttag ctagtggcat 334500 tggatgacac ctataatgtc ttctaaaaat agtagcagtc ataggcacca tttccttatt 334560 cttgaatatt cattcatgtt acaaagttta taggaatttc tgaattatta agtactttta 334620 ataggaatga aggttattgt cattattgca tcaaaattca taagaaagtt tggtgtcaaa 334680 tttgtgcttt gtgtgtagtc ttcatcacgc tttttttttt ttttttaacc agtgttaaac 334740 atccattaca aaaatagttt ggaagttttt cttttttttt ttcctatgtc ctggaaggtg 334800 taagtagaat tggaattatt tgatctttaa gatgtaaaat attggtagaa ttctaccttt 334860 gaaagcacct ggacatggtg acttcttaat aggtgagctc tctggaaact ttatttcttc 334920 tgtagtaatt ggtctcctta gactttctat tccttctgga gtcagatatt gtatatcaaa 334980 tcttctgtta aagttatcca tttcttcttg gtattccaat ttttcacatt gagttggaca 335040 aatgatttct gatgatgttt aaaaaatttc tctggtttga tggttacttt gaccgtataa 335100 tttattttgt gtatttatgc ttcttttaga aacttaggtc agctagtggt tcctctattt 335160 tgttgatttt tttcctcaaa gaactagctt aagtttattt tattagttct actagttttc 335220 tgctttctaa ctcattaagt tatgccttta gctttattaa atccttcatt ctgctatcag 335280 ttaatgtttt agttcatttt ctagcttttt gagttgatac ttaatttatt ttcatttcat 335340 gatataggta actgatgctc agaattttct caaagcatca gttttcgctg ggccccatag 335400 attctaatat atcttacttt cattattatt atttcctaaa aattcagcaa tttcatgttt 335460 tattttgtct ctcattcaag agttgtttaa tagacagttt aatttccagg ttggatgggc 335520 attttgtttt gttttttgtt ttactgttta taaatacttt tggccttggg atcagagaat 335580 actgcttgta ttacaattat tactgaatat ttttgtggtc taatataatt tcagctttca 335640 aaaatgttcc atgtatactt gaaatgaagg tttatttacc cttataaaga tagaaggtaa 335700 aatattagct atgcccatgt ctatttatct tcttataatt tttgcttaat gaaaactaat 335760 gatccattat ctgctgcata agtatttatg tttgctttct ctttattatg ccttatggct 335820 tttgtgttaa aaagctattg atttatttaa tattttggaa ggattgaatt ttaccctatc 335880 taatatcaag atcatgactc ttgattcctt tttgttttca cttgtttaat atatctttct 335940 tctatcttta ttttaaacac aagaagagct ttgctttcag tttctatttt acatagtcta 336000 caatcggatt ttacttatta gtcaatctga gaatactttt aatagatgag ttacacaaat 336060 acatatttat tgataccaac acagtttaat tcaagatctg ttctattatt ttatatttat 336120 tatatattaa attgtcttct ttatttacta tttattgatt tattgaattt attttgcttt 336180 caggtatttt gtatttttgt tctggttgtt agatttatgc atacttagtc aactcttcct 336240 ttataaagca ttcattttct actatgagca gtagtaaaat tagctagtaa cttaattcct 336300 gagcactctc cagtcctagt cactagtaat aacgcagtgt taaactttgt aatattaatt 336360 atacttaagc ctctattact tggtttgtca aaatcaaatg atatcaattt acttccagca 336420 catacctatg aggtaattgt aagctaataa taacttccat ggctattctt ttctcttttt 336480 ttttttttga ggtggagttt cgctcttgtt gcccaggttg gagtgcaatg gcacgatctc 336540 ggctcactgc aacttctgcc tcccgggttc cagcgattct cctgcctcag cctcccaagt 336600 acctgggatt acaggcatca gccaccccac ctggctaatt ttgtattttt agtagagaca 336660 gggtttcccc atgttggcca ggctggtcac gaattcctga cctcaagtga tccaccccat 336720 cagtctccca cagtgctggg attacaggtg taagccaccg cacccagcct ctcatcttat 336780 ttttattact tatatttttc tacattatta gaagttataa tacttatatg cacatttctt 336840 tagccccaac cccatttttt gatattagct ctattattaa gatatttaat gtccaccttc 336900 agattatatg ctgatgattc tctaatcgtt tttggttgtc tggagctttt ttactgttta 336960 ttttcaggaa gagctcatga taactctttt ttctttggtt taaaaatgtt tataattatt 337020 tttctctgga ctttatgctg agaaatttgg ctgcatacaa aatctctggc ttacattttt 337080 tctcaagtat ttttaagtga ttgcttcatt attttgtagt ataaaatgtt gctcacaaga 337140 agctggatgc cagtctgatt ttctttccct cattagtgat ttggactttt tgtctgaatg 337200 ttgaattttt aaatataaac ataaattgca atacttttat taagatatgt ctctgcattg 337260 aacattttag gtccgttttc ctaggtacat agaatgtctt ttgaatatgt agactcaaat 337320 cagacttctt gattctcttg atttatagtt ttaaatattt gtttgggggc gggtgcggtg 337380 gctcatgcct gtaatcccag cactttggga ggccgaggcg ggtagatcat aaggttagca 337440 gattgagacc atcctggata acatggtgaa accccgtctc tactaaaaat acaaaaaata 337500 tagccaggtg tggtggcagg cacctgtagt cccagctact cgggaggctg aggcaggaga 337560 atggcctgaa tccgggaggc agagcttgca gtgagccaag atcacgccat tgcactccag 337620 ccttggcgac agagtgagac tttgtctcaa aaaaaaataa atagggggcg gttccaagat 337680 ggcagaatag gaacagctcc agtctgcagc tcccagcatg agtgatgcag aagacaaatg 337740 atttttgcat ttccaaatga ggtaccaggt tcatctcact ggggactatt ggacagtggg 337800 tgcaggacag tgggtgcagc gcaccaagca tgagccgaag cagagcgagg catcgcctca 337860 cctgggaagt gcaaggggtc agggaattcc ctttcctagc caaggaaagg ggtgacagac 337920 ggcacctgga aaatcgggtc actcccaccc taatactggg cttttccgat ggtcttagca 337980 aacggcacac caggagatta tatcctgtgc ctggctcaga gggtcctaca cccacagagc 338040 ctcgctcatt gctagcacag cagtctgaga tcaaactgca aggtgcaagc gaggctaggg 338100 gacgggcgcc tgccattgct gaggcttgag taggtaaaca aagtggctgg gaagctggaa 338160 ctgggtggag cccaccgcag ctcaaggagg cctgcctgtc tctgtagact ccacctctgg 338220 gggcagggca tagccaaaca gaaggcagca gaaacctctg cagactgaaa tgtccctgtc 338280 tgacagcttt gaagacagta gtggttctcc cagcatgcag cttgagatct gagaacgggc 338340 agactgcctc ctcaagtggg tccctgaccc ccgagtagcc taactgggca caccccagta 338400 ggggcagact gacacctcac atggccgggt actcctctga gacaaaacct ccagaggaac 338460 gatcaggcag caacatttgc tgttcaccaa tatccgctgt tctgcagcct ccgctgctga 338520 tacccaggca aacagggtct ggagtggacc tccagcaaac tctgacagac ctgcagctga 338580 gggtcctgac tgttagaagg aaaactaaca aacagaaagg acatccacac caaaatccca 338640 tctgtacgtc accatcatca aagaccaaag gtagataaat ccacaaagat ggggaaaaaa 338700 cagagtagaa aaacagaaag ttctaaaaat cagagcacct ctcctcctcc aaaggaacgc 338760 agctcctcac cagcaacgga acaaagctgg atggagaatg actttgacta attgagaaaa 338820 gaaggcttca gacgatgaaa attttctgaa ctaaaggagg aagttcgaac ccacggcaaa 338880 gaagttaaaa accttgaaaa aagattagac gaatggctac ctagaataac caatgcacag 338940 aagtccttaa aggacctgat ggagctgaca accaaggcac aagaactatg tgacgaatgc 339000 acaagcttca gtagctgatt caatcaactg gaagaaaggt tatcagtgat ggaagatcaa 339060 atgaatgaaa tgaagtgaga agagaagttt agagaaagaa gaataaaaag aaatgaacaa 339120 agcctccaag aaatatggga ctatgtgaaa agaccaaatc tacgtctgat tggtgtacct 339180 gaaagtgatg gggagaatgg aaccaagttg gaaaacactc tgcaggatat tatccaggag 339240 aacttcccca atctagcaag gcaggccaac attcacattc aggaaataca gagaacacca 339300 caaagatact ccttgagaag agcaactcca agacacataa ttgacagatt caccaaagtt 339360 gaaatgaagg aaaaaatgtt aagggcagcc agagagaaag attgggttac ccacaaaggg 339420 aagcccatca gactaacagc ggatctcttg gcagaaactc tacaagccag aagagagtgg 339480 gggccgatat tacacattct taaagaaaag aattttcaac ccagaatctc atatccagcc 339540 aaactaagct tcataagtga aggagaaata aaatacttta cagacaagca aatgctgaga 339600 gattttgtca ccaccaggcc tgccctacaa gagctcctga aggaagcact aaacacggaa 339660 aggaacaact agtaccagcc actgcaaaaa catgcaaatt ggaaagacca tcgaggctag 339720 gaagaaactg caactaacaa gcaaaataag cagctaacat cataatgaca ggatcaaatt 339780 cacacataac aatattaacc ttaaatgtaa atgggctaaa tgcttcaatt aaaagacaca 339840 gactggcaaa ttggataaag agtcaagacc catcagcgtg ctgtattcag gaaacccatc 339900 tcacgtgcag agacacacat aggctcaaaa taaagggatg gaggaaaatc taccaagcaa 339960 atggaaaaca aaaaaaggca ggggttgcaa tcctagtctc tgttaaaaca gactttaaac 340020 caacaaagat caaaagagac aaagaaggcc attacataat agtaaaggga tcaattcaac 340080 aagaagagct aactatccta aatatatatg cacccaatac aggagcaccc agattcataa 340140 agcaagtcct tagtgaccta caaagagact tagactccca cacaataata atgggagact 340200 ttaacatccc actgtcaaca ttagacagat caacgagaca gaaaattaac aaggatatcc 340260 aggaactgaa ctcagctctg caccaagcag acctaataga catctacaga actctccacc 340320 ccaaatcaac agattataca ttcttctcag caccacgccg gacttaatcc aaaattgacc 340380 acatagttgg aagtaaaaca ctcctcagca aatgtaaaag aacagaaatt ataacaaact 340440 atctctcaga ccacagtgca atcaaactag aactcaggat taagaaactc actcaaaacc 340500 gctcaactac atggaaactg aacaacctgc tcctgaatga ctactgggta cataacgaaa 340560 tgaaggcaga aataaagatg ttctttgaaa ccaatgagaa caaagacaca acataccaga 340620 atctctggga cacattcaaa gcagtgtgta gagggaactt tatagcacta aatgcccgca 340680 agagaaagca ggaaagatct aaaattgaca ccctaacatc acaattaaaa gaactagaga 340740 agcaagagca aacacgttca aaagctagca gaagacaaga aataactaag atcagagcag 340800 aactgaagga gatagagaca caaaaaaccc ttcaaaaaat caatgaatct aggagctggt 340860 tttttgaaaa gatcaataaa actgatagac tgctagcatg actaataaag aagaaaagag 340920 agaagaatca aatagatgca ataaaaaatg ataaagggga tatcaccact gatcccacag 340980 aaatacaaac taccatcaga gaatactata aacacctcta cacaaataaa ctagaacatc 341040 tagaagaaat ggataaattc ctcgacacat acaccctccc aagactaaac caggaagaag 341100 ctgaatctct gaatagacca ataataggct ctgaagttga ggcaataatt aatagcttac 341160 caatcaaaaa aaagtccagg accagacgga ttcacagctg aattctacca gaggtacaag 341220 gaggagctgg taccattcct tcggaaacta ttccaatcaa tagaaaaaga gggaatcctc 341280 cctaactcat tttatgaggc cagcatcatc ctgataccaa agcctggcag agacacaaca 341340 aaaaaagaga attttagacc aatatccctg atgaacatcg atgcaaaaat cctgagtaaa 341400 atactggcaa accgaatcca gcagcacatc aaaaagctta tccaccatgg tcaagtgggc 341460 ttcatccctg ggatgcaagg ctggttcaac atatgcaagt caataaacat aatccagcat 341520 ataaacagaa ccaatgacaa aaaccacatg attatctcaa tagatgcaga aaaggccttt 341580 gacaaaattc aacaaccctt catgctaaaa actctcaata aattaggtat tgatgggacc 341640 tatctcaaaa taataagagc tatctatgac aaacccacag ccaatatcat actgaatgga 341700 caaaacctgg gagcattccc tttgaaaact ggcacaagac agggatgccc tctctcacca 341760 ctcctattca acatagtgtt ggaagttctg gttagggcaa tcaggcagga gaaggaaata 341820 aagggtattc aattaggaaa agaggaagtc aaattgtccc tgtttgcaga tgacatgatt 341880 gcatatctag aaaactccat cgtctcagcg caaaatctcc ttaagctgat aagcagcttc 341940 agcaaagtct caggatacaa aatcaatgtg caaaaatcac aggcattctt atacaccaat 342000 aacagacaaa cagagagcca aatcatgagt gaacttccat tcacaattgc ttcaaaggaa 342060 taaaatacct aagaatccaa cttacaaggg atgtgaagga cctcttcaag gagaactaca 342120 aaccactgct caacaaaata aaagaagata caaacaaatg caagaacatt ccatgcttat 342180 gggtaggaag aatcaatatc atgaaaatgg ccatactgcc caaggtaatt tatagattca 342240 atgctatccc catcaagcta ccaatgactt tcttcacaga attggaaaaa actactttaa 342300 agttcatatg gaaccaaaaa agagcccgca ttgccaagtc aatcataagc caaaagaaca 342360 aagctggagg catcatgcta cctgacttca aactatacta caaggccaca gtaacgaaaa 342420 cagcatggta ctggtaccaa aacagagata tagaccaatg gaacagaaca gagccctcag 342480 aaataatgcc atgtatctac aactgtctga tctttgacaa acctgagaaa aacaagaaat 342540 ggggaaagga ttccctattt aataaatggt gctgggaaaa ctggctagcc atatgtagaa 342600 agctgaaact ggatcccttc cttacacctt atacaaaaat taattcaaga tggattaaag 342660 acttaaatgt tagatcaaaa accataaaaa ccctagaaga aaacctaggc aataccattc 342720 aggacatagg catgggcaag gacttcatgt ctaaaacacc aaaagcaatg gcaacaaaag 342780 ccaaaattga caaatgggat ctaattaaac taaagagctt ctgcacagca aaagagaaac 342840 taccatcaga gtgaacaggc aacctacaga atgggagaaa atctttgcaa tctactcatt 342900 tgacaaaggg ctaatatcca gaatctacaa agaactcaaa caaatttaca agaaaaaaac 342960 aaacaacacc atcaacaaat gggcgaagga tatgaacaga cacttctcaa aagaagacat 343020 ttatgcagcc aacagacaca tgaaaaaatg ctcatcatca ctggccatca gagaaatgca 343080 aatcaaaacc acaatgagat accatctcac accagttaga atggtgatta ttaagaagtc 343140 agggaaaaac aggtgctgga gaggatgtgg agaaatagga agacttttac actgttggtg 343200 ggactgtaaa ctagttcaac cattgtggaa ttcagtgtgg cgattcctca gggatctaga 343260 actagaaata ccatttgacc cagccatccc attactgggt atatacccaa aggattataa 343320 atcatgctgc tataaagaca catgcacacg tatgtttatt gcagcactat tcacaatagc 343380 aaagacttgg aaccaaccca aatgtccaac aatgatctgg attaagaaaa tgtggcacat 343440 atataccatg gaatactatg cagccataaa aaaggatgag ttcatgtcct ttgtaaggac 343500 atggatgaaa ctggaaacca tcattgtgag cgaactatca caaggacaaa aaaccaaaca 343560 ccacatgttc tcactcatag gtgggagttg aacaatgaga acacgtggac acaggaaggg 343620 gaacatcaca caccggggcc ttttgtgtgg ttggggaggg gggagggatg cattaggaga 343680 tacacctaat gtaaatgacg agttaatggg tgcagcacac caacatggca catgtatgca 343740 tatgtaacaa acctgcccat tgtgcacatg taccctaaaa cttaaagtac aataaaaata 343800 aataaataaa taaataaata aatactagtt tggctgcatt gctttgattt tcttctttag 343860 gggcctgttc atacatacaa aggataccat ttacctgtct tctatatgac tttctcttaa 343920 atcctttcat tcttttgttt taatttttat cttcacatcc tttatttctg tcactgtgct 343980 gtccatagag tttgtctgct gtgtgtcctt ataattaagt ctatgttctg aatgtttttc 344040 cttttttaga aattcagttc taaagtgttt aatttctcgt attttttttt ctgttgcctc 344100 accatatcat ttctgagttt tctgtttctg aaatgtgcaa ctaactcttt ccaagcattg 344160 accagattct tcagtctttt taattcattc tgaaataact gggctacagt ttcatctgct 344220 ttgtggacag aagtgccaca aagagccgaa ttgtcagtgc agacccacat gaatcataga 344280 tcttaacgag gtttttacta acgactagca aaggatacaa gctaaaaatg ggtacaagca 344340 aacacagcat cattcatcac tgtaaagact ctgaactatc acatggaact tcaaaaggat 344400 tcttcttctt tgctgcaatg tgttttgatt tttggagtga tagatgtttg ctaactacgc 344460 acgtgacaaa aatttgctta gaggaagcca tgttagtttt gatgctactc aactttgtat 344520 tttgttagtc atgagataga aagcctgtga gattacatgc ccttctttta gcagctgcat 344580 cccataaaat taaaaattcc agtttttttt aaaccatgaa caatttagtc agacttaata 344640 tatcctattt aaaacattct tagataagaa cttcctttgt tattttgcta atatacaatc 344700 ccaccaaatg tctacaagaa gggctagtta atcaatatac caaagatcaa atctatttat 344760 atgaaccaca aatacaaaac ataattatac atatataatt ttatataatt taatttataa 344820 ttatatacat tttatagcag caatcaaaac tatcatgtat tttgggatga atttaataaa 344880 gaaatagcag gagctctgta gaaacaagta tgaacttcta ttggaagaca gtaatatcat 344940 aaaacattaa aaagaaagct ataccatgtt tatggttagg aagattcact attgaaaata 345000 catcaattct tgacaaatcg gtctataaat tcagtgcgtg tccaatcaat atatttagct 345060 catttaaaat gtatatggaa aaggctaagt accaaagata atcaaatgct cttggaagat 345120 gaaaattaaa gttgagagat ggggtaaaaa actataattc agttctaaag tcataaagct 345180 ataataatta atacagtatg gcattggcat agaaataagc acattgacta aataaataga 345240 aaatacagtt cagaaaccaa actctacatt tatgaaaaac tgacctatat cagaacgagc 345300 attgagacta caggagaaca gaggaactag taagttaatg gtcctgacac aattgatatc 345360 tacatagaaa aaaaaactta atccttcttt actctatgta aaaacaataa ttccagatga 345420 atgtaggact taatggagag ccaaaactaa aacttttata ggaaaacata gaaaaatacc 345480 tatctcaggg tcgggaatta ggtcttcaac atggcaccaa aagtactaac cataaaagaa 345540 acattaataa agtcaacctt tttaaaatca acaactttaa ttaaaaaacc agggccaggc 345600 acggtggctc acgcctgtaa tcccaggagg ccaaggcagg cagatcacga ggtcaggaga 345660 tcgagaccag cctggccaac atggcaaaac ctcgtctcta ctaaaaatat aaaaattagc 345720 tgggcgtggt ggcgggtgcc tgtagtccca gctacttggg aggctgaggc aggagaatgg 345780 tgtgaacctg ggaggcggag cttgcagtga gctgaaatcg tgccactgca ctccagcctg 345840 ggcaacagtg cgagactcca tctcaaaaaa caaaaacaaa aacaaaatca aaacaaaaaa 345900 caaaacacag gttgctggaa aaatggttac ttatttttat tatgctttat aaaatataca 345960 gttatattat caaacttctt ttgtaagaat caaatattat gctgagaata tggcaagaaa 346020 aaagaaaaca acctccacca ctcataatgg cattcccttt acccaccatc aactaagtca 346080 ggaacctgcg tcactttcaa gttttctgaa atgtggactg aaaatacttg tggagggccc 346140 tcacagatgc atttagaaat ggtatgttct ggaaaatgga actgaaatgt tttagcgaga 346200 gtcatgggcc caaaccttga aatagaggtt ggtggagttt tctatagtat gtaattacaa 346260 cacaataaga ctcaaaagca tttcaataaa gtgtggatgg aagacaagat actgcttcaa 346320 gggcttcatt agctttctgc agactggagc tctccaaggc atggggagga accctgttta 346380 cctttggttc agaatcagtt ttaaccatca ttgagggcta ggtcagagtg cagcattaag 346440 tccttgggaa tacactgggt ggggaaagaa aagagagcaa tgtttttcta aaagcccaga 346500 aatgggctta ctgtgtttac cagttgtttc caggataatg tattgcagtg ccaattgctg 346560 atgagatggt aggattatac ttcagtccct gctttacatt tatttcttaa agaagcttct 346620 ggtaaattag agcaatagca tcggcttagt ttagtgttgt tctgttggac taaggatatc 346680 agttctatcc gtatggtcgg gcctaaagcc tgggaaatat ttaatgaagg gagagagggg 346740 gagagagtga gcatgcaaaa gagagagaga aaaacaaata acaaaacaaa aaccaagaca 346800 tttcccttta tagtaagaat gatgaggaaa acatgtttag ccatacaaga tatcaagata 346860 atctcttatt tctttcttga aaatgcaagt acaaatgcct gcaaagataa aatatcctct 346920 ggatggagtg gaaaggttca ccaggcctct gaaatcacgt gaatgatgtt gcgctttgct 346980 gttaatgaag ctcggtgcat ttttcatttc agtttctact aagcatttat gagctattac 347040 ccttcccttc cctaaactgc gttgtttttt aaaaagcctt agaggcattc cttctagaaa 347100 ataaaggtaa gtgttaagtg gtgataattt ggtaataggt gtcatgcttg tggttcataa 347160 tgtgttaccc tacacatttt ctcaattatc cctagaacag ctttttgagg atatgaagtt 347220 agaccttaca aagcacatct ttctgctgga aaaatgaggt ttatagtggt taagtttagt 347280 tgcttatgat cacaaggcta gagagtggcc ggaatcaaga ctcttcaccc tgatttcagt 347340 gctttttcac tccaccatta atatttattg ttgataaata atatcaacac tttcctaggt 347400 gtattagggt catctagagg gacaagacta ataggataga tgtatatatg aaaaggagtt 347460 tattaaggag tattgactca caccatcaca aggtgacgtc ccacaatagg ccatctgcaa 347520 gctgaggggc aaggaagcca gtctgagtcc caaaacctca aaaataggga agctgacagt 347580 gcagccttca gtctgtggcc aaaggcccaa gagcccctgg caaaccacta gtgtaggtcc 347640 aagagtccaa aagctaaagg attggagtcc aatgtttgag ggcaggaagc atccgtcatg 347700 ggagaaagat ggaagccaga agacagccag tctagtcctt ccacgttcct ctgcctgctt 347760 ttatcctagc cacgctggca tgatgatgac atggtgcccg cccagattga ggatgggtct 347820 ccatcttcca gttcactgac acaaatgtta atcttctttg gtaataccct cacagacaca 347880 cccaaggaca gcactttgca tccttcaata caatcaagtt ggcactcaat aataaccatc 347940 acaagtccac accttgtcaa cttgatccca catacatctc cttaaatcat acatgatctc 348000 caaatacaga caataatgtc ataattacac tgaacataat acaactatcg ttcatacaac 348060 cagaaatgca ccaattccca aaccaaatgt tattacataa agttaacaac acttaaatgc 348120 tgatatgaag tcaataaata cttttttttt ttaaaagatg gagtcttgct ttgttgccca 348180 ggctggaatg cagtggtgcg atattggctc actgcaacct ccgcctcctg ggttcaagca 348240 attctctgcc tcagcctccc gagtagctgg gattacaggc acccaccgcc acacctggct 348300 aatttttgta tttttagtaa agacggggtt ttgccatcct ggccaggctg gtcttgaact 348360 cctgacctcg tgatccaccc acctcggcct cccaaagtgg tggatcccaa agtgatccac 348420 ccaccttgac ctcccaggtt gtaagccact aaatcttatg tcacatgata caggaaaaag 348480 aaaggaagta aaatgaagat attgtcttag tacaagtgta tacaggcaga aagatgttct 348540 taacaaaata aggaggaaat actcatgaca attacagtaa cctggttgct gcaactcatc 348600 acatggtcgt agctgttatt gatgactacc ttcttctaca acccattctg ttttcccttt 348660 gcctctagca agtacctcag caggtcatgg ttctttacct ggtggagtgt cccaaacctt 348720 cattcctgaa gggtctgggc catttgtagt cctgcctgga tcgagttgtt gtcatttttt 348780 attgacctta atcacagggc ttggtaatac taagagacac cctaaggaat ttcctgtatt 348840 ccacacatgt tcttccttac cttcattatg gagtagtaga ctgagttcat cttgataggc 348900 taagtcagtc accccagcca acactaactc ctttcttagc ctgttgactt agaggtagga 348960 ggagcccgag attgcaatct taatttccag tttaatgaaa tcattattgt gtctcctggt 349020 ggcaacattc atcgccctgg aactgagact tctaggccag cagaacgtaa tgctgtggaa 349080 caagaagcac aaattttact agcgggtctc taggggtgat ggtgagtggt gccacttcca 349140 tttccacccc ttgattcctg gacccatgaa tcctggctat gggagaaaca gtaccaaata 349200 ctggacactg atccggagca tacacagcct tctggaaaac tttgccccag ccctgcaaag 349260 tattgtcgcc tagttggcat tgtaattgtg acttcaaaag gccattccac cgttctatca 349320 atccggctgc ttcaggatga tggggaacag ggtaagacca gtgaattcca tgagcatgag 349380 cccactgctg cacttcttta gccataaagt gagtgccttg ttcagaggca atgctgtgtg 349440 taatgccatg acagtgggta aagcattcca taagtccatg gatggtagtc ttggcagaag 349500 cattgcctgc aggataggca aacccatatc tagagtaagt gcccattcca gtgaagacaa 349560 accactgttc tttctgtgat ggaagaggtt cagtataatc aacctgccac caagtagctg 349620 gctgatcacc ccgaggaatg gtgccatatc gcggcctcag tgtttgtctc tgctgctggc 349680 aaattgggca ctcagttgtg gctgtagcca ggtcagcctt ggtacgtgga agtccatgtt 349740 gctgagcccg tgcgtaacct ccatccctgc caccacagcc actttgttca tgggcctatt 349800 gggcgatgac aatggtggct ggggaaagag gctgagtggt atccacagaa cgagtcatcc 349860 aatccacttg attattaaaa tcctcctctg ctgaggtcat cttttggtga gcactcacat 349920 gagatacaaa tatcttcaca gtttttgacc actcagagag gtccatccat ccacatacct 349980 cttccccaaa tttcattgtc atcagttttc caatcatgct tctttcaagt ccctgaccat 350040 ccagccaaac cattggctac ctcccatgaa tcagtatata atcacacatc ttgccatttc 350100 tccttctaag caaagtgcac agccaggggc actgctcaaa gttctgtgca ttgggaagat 350160 ttcccttcac tgctgccctt cagggatgtc ctagaaaggg gctgtagtgc tgcagctgtc 350220 cacttttggg tggtgactgc atcatgcaga gccatctgta aaccaggccc ttgtcttctc 350280 ttcctctgtc agcttatcat agggaactcc ccatgaggcc atcagtgcag gctgggggag 350340 agaaggcagg gtggcaggag tggggaccat gggcatttga gctacttcct catgtaaagt 350400 acttgttccc tcaggacttg cttgagcctg atcatgtata taccacttcc atttgatgat 350460 ggaatgctgc tgtgcacaac ccactttatg gctagatggg tcaaaaagca tctagttcat 350520 gataggcaat ttaggtagct tggtgatttg atgacctgta gtcaaacata cagtttctac 350580 caaagcacag taacaggcca agagttgtct ctcacaagga gagtagttat ctgcaggaga 350640 tgcagggcct tgctccaaat tcctagaggc ctcccctgtg attgacctat aggggcctgc 350700 caagggctcc aaacaacatc cctatctgcc attgacactt caagcaccat tggatctgcc 350760 aggtcatatg gcccaagtgg cagagcagct tgccaagcat tctggacctg ttgcagagcc 350820 ttctcttctg gatcccactc aaaactggaa gcctttcagg tcacttgata aatgggctgg 350880 agtaacacac ccaaatgagg aatgtgttgc ctccaaaatc caaataggcc tgctaggcat 350940 tgtgcctctt tcttagttgt aggaggggcc aaaggcagca acttatcctt catcttagaa 351000 ggaatatctt gacagacccc acaccactgg acccctagaa gttttactga ggtagaagtt 351060 ccctaaattt tagtcaattt tatttcccaa cctctggcac acaagtgtct caccaataaa 351120 tccagtatgt ttgctacttc ttgctcattg gatccaatca gcataatgtc atgaatataa 351180 tggaccagtg tgatatcttg tggaagagaa aaactatcaa gatctctcca acaagattat 351240 gacacaaagc tggagaatcg atatacccct gaggtaggac agtaaaggta tattgctggc 351300 cttgccagct gaaggcaaat tgcttctgct gggccttatg gacaggaatg gagaaaaagc 351360 catttgccaa atcaatggtt gcataccagg taccaggaga tgtgttaatt tgctcaagta 351420 atgaacccat atctggtcca gcagctgcaa ttggagtcac cgcttagtta agcttacaat 351480 aatccactgt cattttacaa gatccatctg tcttctgcac aggccaaaca ggaaagttga 351540 acggggatgt ggtgggaatc gccacccctg catctttgaa gtccttgatg gtggcactaa 351600 cttcctccag ggatgcaatg ttgtgtttga tttactattt ttctaggtag aggcagctgt 351660 aatggcttcc atttggcctt tcccaccata atagccctca ccctaccagt cagggagcca 351720 atgtgggggt tctgccagct gctaaatatg tctatgccaa ttatgcattc tggcactagg 351780 gaaatgacca caggatgagt ctgggaccca ccagccccac tgtaagttgg acctgagcta 351840 aaattccatt aattaactga tctccaaaag cccctacttt aactggagga ccacgtgatg 351900 ttttgggtcc cctggaatca acgtcagctc agagccagtg tccagttgtc cctgaaatgt 351960 ctgattattt ccctttcccc agtgcacagt taccctggta aaaggccaga ggtctcctgg 352020 gggaaggatg ggagaaagag tcactgcata aattgtcagc aatgtagtgg ggtccttcct 352080 caaggggacc cagcctcccc ttcattcaag gggttctggg tctataaact ggttcaagtc 352140 tgcaaattga ttgaggggcc gtgattcttt gtataatttt taatttaaat tagtcttttg 352200 tctacttgac ctggaagttt tctgcttata taaattaagc aagaatgcag taggcctctt 352260 gtcaatttca ctttttagga acactgagat taagtagcca atgccagagc tctacacaag 352320 tcagactatt ctgattgttg ccttgcctcc gctgaccttt acggtaattg cacccacctt 352380 gccttgatgc ttgagtgcca ccacttggcc catgccacct caggatccaa ttattaccat 352440 tgtatttaaa ttttgtagtt gaatgactgt ggttcccact ataatatcta gcatgcagag 352500 aagagcaatc acagagctct tcaaggatgc aggtgctgcc ctcacaaatc tatttcacaa 352560 tgtgctggtc aaaggtatat cttctgtact ctcccagctg ggatgagtag gactaaagtg 352620 acgaattcac tccaccatcc cagtctccat aagcctttgg atcccttcct ctacattaaa 352680 ccaagggaga tcaggcattt ccagctcact cacagtgggc caccttttga tctatatttc 352740 agctaaccaa gcaaataaac tattagaacc ttttttaact ctccaagctg caacattaaa 352800 tgcagaattc ctgcttagtg ggcccaaatc aatcaattca gcctgatcca actttatgtt 352860 ccttctacca ttagcccaca cccttaatat ccattcccat gcctgttctc cagatttctg 352920 cttatataaa ttagaaaact caagcagttc ttttggagtg tagcgcacct ccttgtgggt 352980 cacattctga acctcatctc taaggggcct gccgggactt tagtctagtt ctataactat 353040 aagcaaacag gggtattgag ggtgggtcct taggagaatc aacatcgtct ttcctggcaa 353100 ctgcctcaag ggaggtcatc gctgatgcct taggcagtgc agggttaaac tcctcagaca 353160 aaggtgaaaa gcctgatggc agcgcaggtg gaggagggga tgttgcctcc cctctgttgc 353220 ctgtttcctc tggtaaaaaa gattcatcag aatttagaag ctcagtgccc ccagccttat 353280 cagggtcctc ccgcatggcc ccattccaag ttgcagggta ccattctttt tcaatcaatg 353340 ctgtcacttt aacagtaaac acctggcaag gctgtgcacg tacctttcgt tgcaggtcag 353400 ccactcacat gataagagct tgtgtctgat tttccgcaat ttcagctctt tctctacagg 353460 agataagact cgaacccagg gcaatcttag aagatttgag gctcagaatg tggttctgga 353520 gctgggagat agaatccctg agttcatcat ttttttgttt tcatcacttt gattagtgaa 353580 cttaggagca accaactagc ttcattatat tccttggttc tccacatatg gttaaaggta 353640 ttaggtataa agtcactaaa ctccttgcct ctcatgagca gtgaatcagg agtatcagat 353700 gcatttattt tgcataactc tctacacagt tcacagcaag gactatcagt gttctccaca 353760 ctattagaag tagagtccct agcattttgg cgtctaatca tatttagcag ccaactccag 353820 aaaccccaaa accatctaaa gaaatccatc cgtaaaattc tgttcctcta gaaccactcc 353880 tggtaccaaa atctgtatta gtcaggattc gctagaggga caggactcac aggtgagatg 353940 tatatataaa aggcagttta ttaaggagaa ttgactcaca caatcacaag gtgaagtccc 354000 acaatagtct gcaagctgag gagcaaggaa gccagtccaa gtcccaaaac ctcaaaacta 354060 gggaagccga cagtgcggcc ttcagtctct ggctgacagc ctgagggccc ctggcaaacc 354120 actggtgtag gtctaagagt tcaaaagctg aagaacttgt agtccaatgt tcgaggccag 354180 gaagcatcca gcacaggaga aagatggaag ccggaagact tagccagtct agtccttcca 354240 tgttcctctg cctgtttttg tcctagccat gctggcagct gattagatgg tgcccaccca 354300 gattgaggat gggtctctat cttccagtcc actgactcaa atgttaatct cctttgacaa 354360 caccctcaca gactcactca ggaacaatac tttgcatcct tcaattcaat cacattgaca 354420 ctcagtatta accatcaccc taggctttag ggatataggg aaaaacatga ctcattgctg 354480 ttatctgaga gtacataatc tattggaaga aaggaaaaca gttacatgta aggcttatat 354540 cagtataaat tagataactg ccaagtgaga gaggtagagg tagcaagtgc tgtctgtggg 354600 tgcatgttaa ctcagtctta atcttggaag aagtggcagt gtggaatggt acatggagaa 354660 gcagaaggga caattactgt gagcagatga atggctcact acaggggcat gggaagaaga 354720 tgcaagagca gtggaatctt taattgacga acctggtacc aagctgccaa gtcttagtct 354780 caggactggc accgtgcact tggccattga aaagactttg gaacctgtgg agtgaagagt 354840 tgtaggaatt ttcaaagcct cagtgtagga acaatgtgag aatcaaccag ggcatggtac 354900 tccacactgt gttcagatcc actggtgtta ggggagtccc agagaggcct cttagagggt 354960 tgaggaggat gggatcaggc atagcagaga ctagggacac gaggctctgc ggccagactg 355020 caggtctgct accaactaca gtgtgatttt gcctagtcac ataatctctg tgggcctcag 355080 ttttttgttt tttgtttttt tctattacaa cagtaccttt ctcgtggagt tgtagtgatt 355140 agatatctag taccaagact atgcttgtta gcactgagta agaactcaat gaaggttagc 355200 tttcattggt actatattac tattgttagt gttggtggtg gagctgaatc gcctaaccta 355260 tgaggttggt gctgaaatga agaaaagaat aacagtgttt taagaagttt ggtcactaga 355320 agtggagctt agtaattaaa gaaaaagagt gaacactttt accttcttgt ggaagttagt 355380 aagtctacaa aatgttaatt ctgcatttga atgatcattt gggagactct tattgtccta 355440 tttgcactga aaaagtcact gaatcattat tttagaactg gaataacacc tgagatctag 355500 gccagcactt tgcaagttgt gctctatggg acttttcatg gaagtggctg aggagttgcc 355560 ttgaaggaag gcagagggag tgggtcttgg gacacccttc cagttataaa acaggacgtt 355620 gattctgttt tgtagttgca gcatcacata taatttcatt tattaagagg atcccacttc 355680 taaaaataag ttgaaaacca gtgatttaat ccagcctctc tgtttgcata tgaggaaatg 355740 gaattccgga aaggttaggt gatttgtcca aggttgcaga ctagactatt tattaataga 355800 gtagggtcag gaacaaaagc ctgctccttg ctggtccagc gcctgttact agttacataa 355860 tgaatgctac ctattgctgc acagtgccaa atcattgcac ttttcagatt ttactctaat 355920 caaaagaaaa aaattaaagt gcacttccaa atcagtactt atatgcaaga gcttcaagaa 355980 acaaactagt atttaacttg gtggttacat attgactgta ttttcattga gtgaggttag 356040 aagagattga gaagcgtgaa atgaagttac aaagtagaaa ctatatggtg aactcaaggc 356100 aaagattgtc catagtaaaa gaagacaaaa taagaatgaa agagacaaaa gaattgccaa 356160 tgagttgtaa tcttaaaaga aagatatatt taataaaata ggattgattg ttttgaatgt 356220 gggctgagaa gtcctgccat cttccattga ctctgctcac aggccttgtt tgtgaactgg 356280 cttccatgga tagcattact ctcctgacag ctgcagctcc aaattcagca tgaaaaggct 356340 ggcaattcta agaggaaggg agggtttagg ccacttttaa ttctactttg tcattgcaag 356400 tttcttgcat tgtttggcat ttgttggtct tccttactgg atttcaaaac tagaacactt 356460 tttcctagcc ttggaaccaa ccacgaaaat aaccacctct taccctcatg aagaacactt 356520 taagtttttc tcttttaaaa atgaagtctg gaatatctcc aaacatcttg tcactcacgc 356580 cttcatttaa atgtcaccct ctcaaccaca aggaaactaa aattgccccc tacttgctac 356640 tccctgtttt attttctagt agaacatact acagttggag atcatctcat ccatgtcttt 356700 tattcttgtc tcttatttgc ctctgcttga ctgtaagctc atggaaagta agggaccttc 356760 accaactagc aaagtgctta ggacctagta agaacctggt caattctaac tgagtgaatg 356820 actgaattcc tgtgagaagt caacatgaaa attcctaggt cattagttta gttattggaa 356880 ctccaacact gtattggaaa agtgtcatgg aaaggatagt tagtggatta aggtttttta 356940 taagaggaag agggaaagaa aggcattgtc tttacttcag gcatttcaat ggccatgatg 357000 gagcctaaat attgtatgtt gcattttgtt ttggttttgt gtgcacaaga gctttgccag 357060 tggaatgaac gggttaagaa atgtgagttt tcttttcgtc ctgctataga gacttaagga 357120 attgccctgt gtgagttcct tgagggcaga gaaaaataca aatccatgaa tacctgaaag 357180 ccctgatttg gcccctaagc aatctatgca tgtaacaaca ttgcatttgt accctgtaca 357240 tttataaaca ttttaagaaa agtataagag aaacacaaat tttggttact cctctctgaa 357300 aactgctctg atgtcgcttg gccgggggaa ttaagacctc ttcctgtggc ctgtggccac 357360 tatgtgctcc cggctctcca ggctcatcca gggccactgt gcctggggtc acagggttcc 357420 aggatgtcaa ccttctttca gcttctctga ctcctcaagc attttttttt tttttttttt 357480 ttttttttgg tttccaagac ccaaacgcat gtctctcttc ttggcacact cttcccaact 357540 tttttcctgg ctaattgcta gttatttagt ttgagattaa atgtcactcc ctcggcctgg 357600 cgcggtggct cacgcctgta atcccagcac tttcggacgc cgaggcaggt ggaccacgag 357660 gtcaagagat cgagaccatc ctggccaaca tggtgaaacc ccgtctctat taaaaataca 357720 aaaaaattta gccaggcgtg gtggcatgtg cctgaagtcc cagttactcg ggaggctgag 357780 gcaggggaat tgcttgagga ggatattgca gtgagctgga tcgcacctct gcactccagc 357840 ctggagacaa agtgtgacac catctcaaaa aaaaaaaaaa aaaaaaaagt cactcactca 357900 cagagggctt ctcagatact cccctgcccc ctcatttaag ttgcaccgct tgttgtattc 357960 tcttataagc cccattcttt ttcttcttgg cattgatcaa attaacagct ttattttatt 358020 ttagcattgt gagtgtatat gtgtgtttaa tgtctgcttc ctgactaaac tgtaccctgc 358080 aggaaggcaa aactgtgtct gtgttgctca ttgttaaacc ttcagcactg aactcagtgc 358140 ctcgaacata ggagattcca actcaatatt tactgcgtga aggaatgaat gaatctttat 358200 gtccctcgtg cctaacataa agtctgccat atacaatgga ctaaaaaata gtattcagct 358260 aaaactgagt tacggagaag atgaagtatt aattgtattt tttacagaga aacaatggtc 358320 agtgtatcaa aaatagagac cctgctctca gatatataac atagaactct cttcattcat 358380 ttgccttcat tttagttaac agaatctgtt catctaagta gagcagagaa aaacttcata 358440 attgctgtgt ctgtgttatt ccaaaacatt taaacaaaag gtgaataact gaggtattct 358500 tccctgtggt acatacttga tgtgggcatt ttaaaagatt gatcaaatct cctttcagct 358560 ggatatttga gtaggcacaa ccattacaga attttcctct agggacttac tttagctctt 358620 aaactatgta aactgaacaa gcaaactcaa gtggatcatt atctatagaa gtatagaatt 358680 ccatctccct ttggcaaacc attcaaaccc agaagtgtgt tttacacatt ctgacagaag 358740 catctgtaat aaccaactct aacctccttt cttaccactt tagcacccaa aagtataaga 358800 aaagaggaca tgttaaggct tgttctattt attagaaaat atataaagag ttcttggctt 358860 aagaactctt ctggctatca gctccctgat gtgaaaaaag taaatagcaa ggggtagcat 358920 ggagtcttac tcccgtgtga cagacagctt aagaaagaca attggacatc atgtgactac 358980 atgattcaag ctaaagtcca gacacatctt ttccataggc caattgaaca ttttctctgt 359040 aatttccaca ataaccattt gcaccagcat gaatggagag ggtctgagtt cttctgggtg 359100 agtaaagggt gtgtcagtta tctgtcctct gtcaccagga tttagaggca ggctcatagt 359160 gactcttgta aagttgaggt tcgcctgtgg aggctgcaaa aaagagggag gaagagagag 359220 tgaggttcct cttggctctg tgccagggat gtgattagag gaccctggga gggccttcat 359280 cctacgaggg gttggaagtg gaaatggatg tgtgtggatg acctggtaac gtgtcacagc 359340 cccttccacc ccatagtagt cagggattta atgcctcaac aaggcaggtc tctgaaggag 359400 actgactttt ctctctctct ctgaatgata ctgcctgaga gaaatactca cttcctgctt 359460 tgttttcaac aagtatggac ttccttacac aaaaagaatc ttttttgctt ttgtcccccc 359520 atttcactgg aaatctatcc actgggcacc actgttggtc ggcttccttt catagattcc 359580 tttatgtttc aaattttaaa aagacaataa tagcaacaaa gtgaaatatg gatttaagct 359640 aggaaaagca gagaactgaa acttttttcc tgcaatcata cttcccagct tcttcagcaa 359700 gatctgcttg gctgggaaca tgccttctga gaactttaca tttctaaact gctgctaaat 359760 tgctccatgc atttattcct caaactctca gggaagatag cactggcttt cagtctcata 359820 ccaaccattc ttaaggtaat ggaccaaaag tcatttccac ttgaaatata atccttctaa 359880 atgaatcatg caacatggtt tttacctcca ttttttcaga ataactctaa gatgatgatc 359940 ctctggccat attttaaaaa tttctcttat ttgttttaat tttcttccat tttttcttta 360000 attttgtatc cagacactgc cttctctaag aggaatgaca tttttgcggg ttatcatgat 360060 atatttttag cccatttgcc ttgacccata gcttacaaca gttaaagaac actaacatat 360120 aaacatagag ttttgcccaa ggccattagc tttgcatgtt aacaagtggg cagaaggaag 360180 gctgggcatg agagagacat gctgtccttc tggtgagatc atcaatccca ttcttgtaac 360240 cttcagatca ttgcatttgt tcagaatcgt ctgcagagga aaacatctca aagttgggag 360300 gttgttgaag agtcagaaac aaatgggtcc tgggtaattt ttcaaaacag gctttttgtc 360360 aattgtcagt cagctgttta atattgtcaa ttgtcactca gctgtttaat attgtgcttt 360420 gttataagga taggcactgt ggtctcagcg ttcttaagct tttacatttc cgttatttgg 360480 ttttacttct gcattagtag agtagatgta gagtagatgc cacctctagg aactctacca 360540 gcagcagcat cttagactag aagctccctc tctaggacta taatctctgt agcctccact 360600 tctcccaccc cttatttctt ctgagcctac ttggtctttg atacttacta taatactttc 360660 tattctctta tcataaacag ttttctgatt tcattttcct ctggtttcat actaagcccc 360720 ataatcagtc actgcaagat taccttctag aatttctgtg ccctcaagtt ttctccatat 360780 ctagagagtc agtcatctgc cttgagccac atccactgtc tactttcttc acttccatcc 360840 ccaggctgcc cagcactgat gaaaacaaaa caaaaacaaa caagcaaaca aaaacaaaaa 360900 caaaaaactg actaggatct caatctggtt tgcaaatcca tgcttctctt tcttgacttc 360960 tttagacatc aacagaattg acgcctcctc ttgacctggg acacccctcc tccttggtgc 361020 tttcttctac ctccccctgc ttctctgtat gtcttttgca ggctcatctt tctcttaggc 361080 tgtcttcccc catctctcct ctccctctgt gcactcaggc agtctccctt gtcaaccccc 361140 aaaactgctt ctccagaccc cagtgtttct ctgagctcca ggtccacaat tctctaaggt 361200 ccatgtggat gtccctcacc atttcaaact tctcttccac agggagtccc tggttttcac 361260 taccatagca tattaaaata ccatgcattt cccttcatac cactaattac aactttgttt 361320 ctttttttta aattttatgt tttaaaaatt atcttctgcc cacatatatt gtaagctcct 361380 tttgagaaag acacattgct gtcctggtca ttactatatt cttatcaact agcaggggcc 361440 gtggtcgggg cttgtgttag tccattttgt gctgctataa aggaatacct gatgccaggt 361500 aatttataaa gaaaataggt tttatttggc tgagggtttt gcaaactgta caagaagcat 361560 ggcgccagca tctacttctg gtgaggcctg aagcagcttt tactcatggt ggaaggcaaa 361620 gagagagcag gcgtttcaca cagcaaagga gagagcaaga gagatgccag gctccttaaa 361680 cgacctgctc tcccataaac tgaaagagca agaactcact cattacggta ggatggcacc 361740 aaaacagttg tgagggatcc accccgaaca cctcccacca tgccccacct ccaacactgg 361800 gatcaaattt caatgtgaga tttggaggga acacacatct accctttatc agtgctcaat 361860 aagctcgctg aatgtagaac agtgatataa ggcaggggtg ggccaagtat aggcgacagg 361920 acaaatttgg cctgctactg cttttgtaaa taaagtttta tttatttaca aaataaataa 361980 ataaatacag tcataatcat tggttacatt ttgttcaaag ctgcttttgc attaaaacat 362040 cagagttgag tagctgccac agagactgta atggccccac aaagcctaaa atagttaccc 362100 cgtggtcttt tacagaaaaa gtctgatata aaggacagtc tcacagcaca gaggaaaagc 362160 atataaccca aaggaggaaa gagtagagca tagtggactg cagagaagtt tccctggacc 362220 caatctgtgc cttgaaagat gagaaggaca cctccaaagg caggatgggg gtgaggtggg 362280 gtgggcggtg gtgatccaag cagacagcac gggcaagtgt tctggaaaac ttgcctttgt 362340 tcacaagtat cctgcagtat aaattgcaag gtgggcagta agaaatggac ttgaagagat 362400 tgaacaaggg ccagaaaccc aaggacattg ctaaggagtt tgtgccttag cccatccagg 362460 gccctagcag ccttgactga tgcttctgag gtcctggagg ctccaggctc aggctacctt 362520 cccatattct ctgaaaataa tatcacattt gtttagtaaa aaaattgttt actaaaaaat 362580 taacctctca gaatttctgc attcacattt atttcttctc atatcctcga gttagaaaaa 362640 ggtatttctc tcctgtgatg atattgattc tgcactcatc tattttcatt actgtctcct 362700 tccctccctc cctcagtccc tcccttagtc tatctcactc taccatcttt tcctttggac 362760 cttctgacat tcaacatctt ggtcgctcct atccagccac acctctgacc attcaaccat 362820 ttgtcctctt gattggttcc accttgtcct atcacgctgg atatgctgtt gctcccaaat 362880 tgcctccctc tgccagtttc ttgccccttc ctccttctgt ctctccctct ctctttcaat 362940 ctttctctcc ctcagtctct ctttctcttt ccctctctct caatctttct cttcctcagt 363000 ctctctccca ttctctttct ctttctctca atctctctct tcctctctct cttatcctct 363060 ctttctctca atccctctct ccctctttct ctctctcaat ctgtttctct gttaatctct 363120 ctttctctct ccttctttct gtctctgtct ctgtctgcct ctctctctct ctctctcttc 363180 cctagtgagc tcacttgctt tcccagtttc agtgatttct attcagatat ctccaaaatt 363240 tgtatttccg gatattttat gctttcatgg aggccgtgta aattggtata acctttttgg 363300 aaggcgtttt ggcaatactt agtaaaaggt taaatgttta caccccttga ttctgctatt 363360 gtatgtgtaa ggattttttc ctgcatactt ttgtaagtgt agaaaatata tgtataggaa 363420 taattgcaca ttgtttgttg tagctgaaaa ttacaaataa tataaatgcc tataatcaga 363480 gcagttaaat acatatgaac acagtgaaat accaggcact catttaaaag atgaggtata 363540 ttttaacaag cctatttgaa aagataccca atcttagcaa gtgaaaaaaa aactcatcaa 363600 attgatatat ttagcgctgt ccctctctca agtttcagac ccacattttc aattttctgt 363660 tgtcatcttg acttagtctc gtgaaatttt aaactaatca tttttaaggg aagatatttt 363720 cttcccttaa agatgaaatt cagacaaacc tctgaatttc cctctttctg ctaatttctt 363780 gctttctttt atcatctttc catccatcct aacatacagt tccagaggag tctttaaatc 363840 cttccttatt gcctaacacc gaggatcatt tgctgaaatc ttgttgattt ttccctcaga 363900 tcaacaaagg attttcagaa tagccctgat ttctctttat caccacggtg ctgtctcacg 363960 tcttctctcc ccctcctcct acctgccgtc tcttccagac tcgtctctct cccccaatct 364020 cctttgcgca ctgatgccaa attagtcaca acaaaagtgt ttacgtgatc gtgtcaccca 364080 ctggtaagct cttaatggtc ttcccttaca cattatctcc catttcatct caggagcctt 364140 ttattaacca ctcttcacag tctgactcag ccctctttgc cagtttctct ctttacaaat 364200 agcaaagtct atgagctaga ttactcaata ttccctgaat aggtcttctc ttctcccacc 364260 tcttggcctt tccagtacca ttcaatcttc ctggaaattc ctgaaatttc tttcctcctc 364320 actcagtcaa tgttttgaga cccacatcaa atgctacata ctatttgttc ctttactgat 364380 catgccagtt ggaaatgatt cgaatctgta aagcagggtg ctatggaatg acatttctta 364440 tagccctttg gtcatttggg agcaatgtct aacataatat cctccaggtc catccatgtt 364500 gttgcaagcg acaggatttc cttcttgtta aagggtgagt agcattccat tgtacatata 364560 ttccatattt tatttttttt tgctcatctg ttgatggtca cccaggttga ttccatatct 364620 tggctattgt gaataatgct acagtgaact tgggagtgca gatatctctt caacatattg 364680 atttcatctc ctttggatat atacccagta gtgggattat tggatcaaat ggtaattata 364740 tttctaattt tgggcagggt cctctgtagt agctccataa tggttgtagt aatttacata 364800 tccaaccaag cacgccaggg ttcacttttc ctcatgtcct cgccgacaag cctgatattc 364860 ttatttgcct cttagcgctt cagcctttcc ctcgtgactt aacggtgact cccttgagac 364920 tacttgaaat aataagtttg gatggcaagg aaataccctt ctgctgtcac cctttgccat 364980 aagactgagt tactttgtaa acaaagaaga tttacttggt cttccatgcc caagaccctt 365040 ttacttttca tcgcttaata tttcatggcc aaaaactgtt ggttcttcca atcttgtaag 365100 gccatttatc tttgatcttg ctccattccc ttccattttt gcttgagaat cattcagttc 365160 ttgcctgatc tcacgtcttt ctcgcaacac cttactaatg actgccagag tgtccactac 365220 acactatcgg tctcatttga ccacttcccc aggcatgtag cctacctgcc aagttctttc 365280 acagcagata ttttgcagtg ttgtaagagg gctccctagc ttgctatgtt ttcttactac 365340 ctggcattag gaagtaaaca tttttcatgg cagtattcac ttctagtacc aatttctttt 365400 ttaatctaca tgggctaact gctgtatcaa acagccatca aatcccaatg ttaattgcaa 365460 cttacagtac gttgtgatgt ttctgtctgt atactcattc agacacacag agtttaagta 365520 atttgttcaa gatcacaaag ttagtaaatg gtggcatcaa gatttgaacc caggcagctg 365580 gactcaagag tctaaacaac tttcatttta aaattttcat ctttcaagat atatcactta 365640 caatttccat cttcatcact ttcttccata cttcagagct gcatatgtaa acctcttgat 365700 catataaata tttatggagt ctcagcattt tgagcacatg ctgagagatt ttgtagcatt 365760 gaagataaag aagctctttc aatacatcta atcttgccac tattgatttt gaacagcatc 365820 ttaatttgtt acctttttaa aaccatattg tacttttctt caggacagct aaattaaatg 365880 tcttatgttg atcccctggg ttttctcagt ttccatttat cagtttcctt ttatataaag 365940 agatgctaat gggtaacctt acattttgta aggcatattt ttgaagatat acaagtgaag 366000 gtttgatctg tacaccctcg ttagagctct ttattttaca tgtggaggaa gagatgcctt 366060 agggcttctg aaaaacaggc ttttattttt atagaggaga aacttccaga acatgccatg 366120 agcaaatgct ctgtcaagtc tggttctttc ccccattact taagtgcaaa tggaccacat 366180 ttgaagaaga taagtagcag aacaaggctc cccacaaggg gattttgagg tgctctgaaa 366240 accagactga cataatccat ggaggagttc atcactgcag gctgtcacgt ctcacagtgg 366300 gagtcatagg ctggtctgct tgataaacta ctcctgatct atgactggag ctgtgtgctt 366360 cctttaaaaa taaatcttgt ttttccatgc cccacgtgct tctcagcctc aggagcacct 366420 catggattta gactaatctt gtcttttaca gtcatgttac ttccagattc ctaggaatca 366480 ccccatttct gatgccgttg atccatccat acccactgaa attgagctaa atgctctagt 366540 ctgatttgcc ccttgaagtt agtatagaat attttggcta gactttgaaa atgaagccct 366600 gaccacaatg cataatgacc tcagtagaca ctgaagagtt cctttgcatc aggcaagtga 366660 caagtatcta tctcatcttc aaagtccaca tagatatgtg ccagattgta ggttgacaaa 366720 tcactttttc actagctcac gtggcaagcc ttttcacctt gtaataatgc tagtgagaga 366780 cccataggta ccacataatt ggccagtcat tgagattcaa gcaacatttg gataatttag 366840 caaaactatc atcagaatca tcaaagtaca taatttttat ttattatgca aatagtggat 366900 tcactaaagt gcttagacca attaagttgc tcccattgaa aaacagggtg attttattct 366960 taagaatata tcaggataaa cttcttgtag cctctaaaca gtactgctta gaaaagtgca 367020 gcttcactgc attgcatatc cccccagaag ccctcaaagt tcagatgtac accacaaaaa 367080 catgaagcac atgtgtttgc atggaaggta ggctctgggg tcttcctatc ataatatgtc 367140 tatgattaat agtcaacata tgccccctcc acattcccta aaggaacata cacatgcata 367200 cacacacaca cacacacaca cacacacaca cacgtgagaa ctgaattgag agtttggggt 367260 atacaccatc cctgagggca cagtctacag ctcctaatgt gtgctgtaga gcaagcatta 367320 tattgttgac aggtaataat tcctggttag gaataacagg ataccagtga gaagaggctg 367380 agaaaaatac actcttgctg gaagagtcaa gaacgagctc ttcgtgggaa actatgggag 367440 acgattgaaa aaggacaaga agaaaggaga attgttaagt ctccactttc tcagtttctg 367500 aactgaactt ttgctcacag caggtgaaca caggctccct cccacactga gacttcctcc 367560 cctgccggtg tgcagtctgt taagtaaaca gagacgttat actgagaaag gaacatttct 367620 ctattttggc tatgagttgt tatttttaaa gattcatcct ccaaacattt tcccctatcc 367680 ttgtttattt tttcactaga aagaagatga actgcttaaa aaaaaaattc aactccatga 367740 caagaaaaac ccacttctag tatgttctcc ccactcaatg ccaatggagc ctttggtgtg 367800 agcactctgc cagccacaca ttgggcagca tacctcttga aattcctgct gtgcttctat 367860 agagcttcca tgcatccaga ttttcaaagt caaagcaaaa tgcgcatggc agtttttttc 367920 tgactccttc aagttaaaag gccaacctct cccttgacat atccatgtat ttatcagtat 367980 atctataggt aatacttaaa ggtgatcctt actgtgtgcc acactccatt ctaagcactt 368040 tacataaaaa acctcatttc actttatttg ggaataggat gacaatttct tcaatattga 368100 gatgggttga atctggggag actgatgtta gatgcaaaaa gctttctttc tagaactttt 368160 cctgtgtctt gcacctggct ttctccctgt cttgttccca ttctagatct ctttactgac 368220 agtgcccatg gctttcttct tggtactcta gtgttgagca taagaactag tatgtaatag 368280 gctctcagta aatcttgttg aatgaattaa agtagagcaa gaattaaaga cagagaagaa 368340 gatcttcttg ttggagttct ttcttttggt tgataagcaa tgtgatttga cgtaacaatc 368400 ttgagtccta atcccctcat ttggaaaatg gaaataataa tgctaatctt agaggtcact 368460 tctaagaagt atatgaatat atcagaagta atcaacattt ttaagtcaaa gaaaagaacg 368520 tctgtgaaaa agaaaactaa tgagctagtt gaaaaaatat taattggatc tttttctcat 368580 accttacgcc aaaataaatc cccaaaaatg gttgcacaac attgtgaata tactgaaatc 368640 cattgaatca cactctttaa atgggcaaat gttatgttat gtgattatct ttcaataaaa 368700 ttgttataaa aatgaataaa ccccagaaga tcaaaaattt aaacataaaa gcatggaagt 368760 atactagaag gaaatataag ataattttat atgttatgtt gtatatattt atatgtaaaa 368820 tttttttatt tatttttctt tgcttttaaa agcaagacat aatgttctag aggaataaat 368880 gaaacgttcg ataaatttaa ttctctatta aatgttttgc agaagaaaat accaggaaca 368940 acatcagaag aaaaaacaaa aaaccataag aaaaacaatt aaaaatacat atgacaaatg 369000 gcttattact ataatattta aagaactctt aaaaatctat gtgaaaatga caaataacag 369060 aaaaatacgt gcaaaggaca agagcaggca gtttagagaa agcctatacc aatatattct 369120 cttatcaaca gtctattgta caagctattt gaaagcaatg tttgaactat caaaatttaa 369180 aatacataag cccttttatc tagcaattct acttccaaga atttattcta tagctatctg 369240 tacacatatc caaagacata aacataagga tagtcattga atgaaatgtt tttaacaaca 369300 aaatacttga aagcaaagaa atgtcaccca agaaagaagt gattgaagaa agtttagcat 369360 tcagttcagt gaagacatat tgagctgtca aaaaaagttg atggagaact ccaaggtcta 369420 ttaactaaaa acaaaacaag gtgctaaaca atatgtttag tgttcatatt ttaattgttt 369480 atatatttca caaatatata tttgtgcatg cagaaaatat tttaacttct ttctaacccc 369540 gtcaaacaca tcatgccaaa attcaacttg tgataaagaa aaaaataaat gaattccttt 369600 cgtgtgtagt atctcattta aattcttcaa caacccaata aaaaagatac agacacatgt 369660 ttttaagtac tacatgttat gcacctttgg tttgcttatt taatagttgc aactactaat 369720 gttaaattct tgatgccaag gttaaaagcc tgaacttcta aaaatatcaa gatctgacat 369780 ttttctgttt tcacagatta atctgccatc tcctgacctc caacacactg ctctatgttc 369840 tttcatgctg ctcctcctcc catgtttagg accctcttcc aaggaggcat tcacatctct 369900 gcttgatgaa accctacatt atcttaaagc gtccactcga atgccaccta cttatatacc 369960 atctcctgca ataccaatgg gctcagccca accatagccc atagttattg tagttgttct 370020 tgtacttcaa aagcactaca aaacacaacc atcaggactt gttacattat ttgaaggcta 370080 tgagcatctt cagccgaggc cctgttttta ttcccagaac taccacattg tttagaatat 370140 agtagcagat caatatacgt gtattagata aatcgtttac ccagatcttg atcattttca 370200 attacccata ggttgaagaa ctccatattt aacatggcag acttgaggac tgaactacct 370260 acctcttcta agaagttgaa atgagaatgt tttattgatg ggaaattatt tttttgtttt 370320 gccttctaga attcaaatga atgttcatat tccatgaaga caatggctga tagttttttg 370380 ttaaagattt agaaccagtg gatttttatg aatgtgaacc ctttcatgtc ttgtggaaga 370440 ttttctgttt tttaatcttt ttatttattt atttattttt gctatgtttt cataggaacc 370500 agggaaaatg tgtagagggc atggtggaga tcttcgacat gctgctggct acatcatctc 370560 ggttccgcat gatgaatctg cagggagagg agtttgtgtg cctcaaatct attattttgc 370620 ttaattctgg tgagttgata acacaagata actcaatgct ggatgaaatg tttatttgta 370680 gttttcaacc agatacgatc tacccactcc aaaggcataa tgtcataaat agaaagaaac 370740 tactgacaca cgttttaaaa taacctacca acattgcaga ttccttataa aggtagaacc 370800 atgctagcca aatagacaca tgaaaaattg taatttggca ttgaatcaaa tggcctttga 370860 gctaaaattt ttgtatgctt tcacagatag gatgttttta ttcaaatggt acatgtatat 370920 agacatatgt tagttgatag ttatattatg tctgaaaata agtagaccaa gtaattctgt 370980 taagaaattg tgaccaattc caggctccag atagtaaaga aagagggtta tttgagacag 371040 accatgtttc tggtcaaaac tgactagcta aaaatatagt tggcttagag atagaaaaac 371100 ctgtttctaa aacagaagaa tgtggaatgc aataaattgt ccagctgaaa gaacattttc 371160 catttgctct atgaagtctg attctactgc cccttcgtat ttatttgttt gagaaagctt 371220 agctaagagc aacatctgtt ttttgttttt gtttttgttt ttgttttgtt tttgttttca 371280 atgtagtgag gctggctgtt gtataaagag ttactctatg tcaccaagat ggaaactatg 371340 gttcagcctg aattagtgcc ctgactcctc ctagcctctt ggtatttgga tctaagctct 371400 agctctacag cctctgggac ctaaagctca cattgggtat cagcggtaca gcagctcccc 371460 ttaagctcca cctttccccc tggctctaac cccactttgt gcctcatccc tcattctcac 371520 atagaaatca tagctatttc gaatctctgg gcctgactta gtttcttatg ccattagaca 371580 tagtctcaaa ttcctcaata gctgaattgc agcttgtatt gatcacatac atagagaatc 371640 cgcacttcct tctctttcca cgtgtttttg tctctttctg atgagtgctg atcccttccc 371700 gcttccccta acaatttttt acttttcttc cccaccactg ctaggaacct gtgttgctta 371760 atggaatcag cccttccttc tcttttcttg tgtttttgtc tctttctgat gaatgccaat 371820 cccttcccac ctcccatgac aattttccac ttctcttccc caccaccact agtaacctgt 371880 gttgcctaat ggttatcaca gtaatcattc tcacttatca actaataaat ggaaatctgt 371940 actattacac taggcaagga ctgaattaca gaatgaagtc ccatgataaa tgatgtgatc 372000 cacactaagg aagtgattac cactccattc aggtttctgt ttccactcac gtgcattgtg 372060 cttttcattt cagtcgtttg tcctgtacat tgtagggtcc agatcccaca atggctcttt 372120 attggatgag agttctggga gcagtgccac tcagctacat ggtgccaggt cctgaacctg 372180 tgccttcttc ggtggagggc tggcacgtgc tgacagcttt catgtgggca atctgggaac 372240 ttcagagaag gcaggcctat taagtgttaa gactccccac cccgaacttt tactgagaaa 372300 aagtacccca gacaggaagt aaaattagcc agagttgtat gatccacaca gtggatgctc 372360 tgatctcagt aataaaaaat atttcctcca gatccatata gacttttcct gcattattgt 372420 tttgtttctg ttcctatggc agagtgagtt tttaaaacta ttatgcaaga aatatcagga 372480 tttttgccac caaaaagttg gattcataga cccagggttt ttacaaccca gggggaaaaa 372540 actttcagcc ctcacaagaa agtattttat taaagactgg cacccaaacc tcaagactat 372600 atttctcact gcaggatttg gcccctgtct gcctccttct cagactagtt aaactttcat 372660 actccatcct tgttccttcg cttctttctt aggatcttct gtgcacttct ttcttaggat 372720 cttcttggca cttctttgct cttgaagggc agaaacgcta ttgtagaaat tcaaggcact 372780 gtatgctgac atagtttata gttgtctttt tcatgagata acacagcggc tggcagctcc 372840 tcttttctat caaggacagt actgctggct caggagagca gtaagcaaac agaagctgtc 372900 tctcaaccct gtacaaagcg aaaccactct tttccctaca aaagtgagct gtgccccaga 372960 aaagcggatc tgctgctgag cagggctcct catgtctcct attgttcctg aaaaacagca 373020 tcaaagaggg caagactgac acacaatgtt gtagcattag gagccttttt cagaataaaa 373080 aagcaatcag tcatatgaag catgtggtca taccacaatc aacaattttt ctccacaact 373140 ggagatatgg atttttctaa aagtccaact gattcatggc cctgatacgg ggcagctcta 373200 cctctcatga gaccaatgac caagtgactc tgactccagg aatctctgac agaagccaag 373260 ctggaaacgg ctcaggaaac ctgagctaga agatgccttt ctgacacctg ggaaacaaaa 373320 cctcagtgta tggaggaacc caaggttttg tgttgagccc cagtcgccaa ggtctgagga 373380 ggctgggttt atattggccc cgattttgtg gccgaggcac aaggggaatt gaaaggttgt 373440 tgtgaggacc tgctcggaat gtctttctgg aagtttggag agggtctctc aaatgccaaa 373500 atttccatgg gaagccattt tcacagctgc ttgggagtgg gagatattcg tcatcatttc 373560 tgccccattt agaataattt attactttgc ttgcaaaaac ccggaatcat ccataggaca 373620 cacgttgttt gtttttccac tccacaccaa aggacagagg cattcctggt taatccaaga 373680 tgccaacttc aagacattct gagaactagc tggacagagc tgaagtgtag ggcaaatcag 373740 aacagaagtg atgggcccag ggcaaaagcc cgtgaagcag cagctgcgga ggaaggatgg 373800 gagctggagc tgcaaagggg gccatggtgg agactctggg cctgcccaca gtatcccctc 373860 tgcccaatgg gaattcagtt ttcctgcata tcattcaatt atttctcatt tttctaggcc 373920 tagctcacct tattcgggaa gttttgcgac taccccagtc cataatgaat ttcctctcta 373980 gactatttca attcttacag tcactaccac acagtctagg atttggttag ttggttgatt 374040 tcattcattt attcaataat tcaatgttta ttgagttcct actatggact ttgtgccagg 374100 tatacaaaac tgaatgttac tgttgtgtgg ggtttttttc tttgcatttt taaagttaac 374160 ctggattttt ctctcactct ttatgcatgt atttcctaat ctccctataa actatttgta 374220 tttttttgga ttcctcacag tctatttagc ctgtggactg tcaacagatg ttacatcatt 374280 cagtcattta atagatgctt atttgctaga catggccagg aggacctgga aagtcctcat 374340 ttttcccatc tgttcttacc attctgaaat gtatcatgct cttcagtgct ccacagatct 374400 agatgatatc aaattattaa atggaaaaag caagacccat ctccttgggt tattgtggat 374460 aagggggaaa ttgtgtagga agtgtctatt gcagttcatg gaccattgta ggcccttagt 374520 caacaacagc tatcatcatc actgatgaga atctctggct taaacggagt aggttcatgc 374580 cttttttcag tgtaatgaag tgttttagtt taaaggcctt tagcaaggct tacaataaaa 374640 aaaagtgggg actccagggt aacaccaaca atagagacga ccatggctgt tatcctgaga 374700 ctattaatta tgccacgtaa ttagatttag agaaaactta gagcaacatt tatcttgtgg 374760 ataataattg attgtgattg ggacttaccg ttgagagacc ctgatgaaaa ctctatggtg 374820 aattgctgtg gagtcacatg ggttcatgca tcattcatca gtgggccctg gttttagcct 374880 cataacccct gagaatccac ctctatcaga aaaccaccct ttcagtgaaa gttcctcaag 374940 gctcagaaaa attcatatgt caaagcttta tatgtaaaaa cctatactct ctaataaatg 375000 tttggtttgg ccttcacatt caatttaata attatttcta cctcttttct aaaccgctct 375060 taaccacagt tctatatatt taattctgaa gagcctcatg cacctccctc cctggtaact 375120 ttatctactt ctctccctgg agaaccagcc agaccatgat tccagccctc tgtcctctct 375180 tcaaccgtag gtcctctttt tctctcctga ctcctcaaac cttctccagt tacccggatg 375240 ccttctgtgt gctgctggct tctgcatcac tgttcacagg gccacttgtt cccctggaaa 375300 tgtcttatgc tcttgaaatg ctatagcctt gttcacctgt tcatccaaaa ctgatcctca 375360 gacaacattt ctctttcaat tggtggaata ataaagagga atatgggtca aaattcatag 375420 acatttaaat acccaaggtg caaagttaag agaaaacaag ataggagaaa gaattatggc 375480 aacatctcta aaatgtgtac tttagtgttt agcaaaaaag ggactatgga atgtcaaaca 375540 ggaacatata tgttaaacat aaacatgaag cagtgccagc tgctgtctgc catatagtca 375600 tgctttgtta atgtggcaca tcttgccatg atggtgccct catgaaacga aggatgctga 375660 agcagatgcc attctgtttg ctttgatcag aagccactct ctggtcaagg aagtatttgt 375720 ttcatgctta attataacaa gttctcatca caaagattat tttctttctc cagatctgga 375780 ttgtttgcac tcactttata ttattagaca attactcaga ttgtttatgt ttttatgttt 375840 agaaataaga cagtgattca gagagtccct gtatttagat gaaagaacat tttttaaaca 375900 tattgactgt aaacactgaa aatcattaat tctcaacagt tgaaggtttc tgacaggaac 375960 ggcccttgga aattgtaaat gggcacattg tcaggtatgc ccattgttgt cacattggag 376020 aagattggat tctgttctct ctggagtcct ttgtaatgcc aagcttcctc tccagggagc 376080 tggcttattg tcattatttt gagataaatg gcacttcata gtattaagtg gttcattgtc 376140 tcttctctgg ctgactgtat tctgtaggca gccactcaac tttggagcct ttctctgcta 376200 ccaacttttg gtgttgcctt aagcaagcct catggctcct gttagtttcc tgacaacatg 376260 gtatagcatg gactttgtca tcagagagga ctgaattcag gagaagcaac tctgccactt 376320 ccttggcgga agggggatga ctgatgtcct ttgataagct gcttccctga gcctaataaa 376380 aaaatagaaa taatgatact taaactcatg gaattgttgt gacaattgaa agaatgacca 376440 gttagtaaag catcttgcac catgactagc acacagtaga tgcacatgag tgttactaag 376500 ctttagttat gccctccaaa tacaaagcct tagttttgtc actatgaaag aaattactct 376560 gttcttctta gcaggtaata aataaatccc tgcctggaaa ttctgcagga gaatttcacc 376620 cctgcgcttt caggttaaaa gattgcattc ccatgatgaa gatgttctgt gaatagaatc 376680 atctcaagtc ccaaatggtg tggatttgct cctgcatctt gttgcagaga ttctcttgga 376740 gcttctgaga actggggaaa ccaacaaaat gcctgtagcc tggggaaaat gtagggagtt 376800 ttagcatgaa tttgtgggag gtgagaaaag gcagcaggtg tcgaaagacg ggaaatcctt 376860 gcactgttct agatgttagg agccattttc cattcacatt cagcacctca ggaggagaag 376920 ctgcctatca ctttgtgtcc tcaagagaac caacaaagga gaatgccatc tcccagatac 376980 tcaatttgat taccatttta tcctaccttc tctagggtcc agacattatg taaattggca 377040 ttaagtttga ataatgtatg gacccagttt aaaaggaaaa aatgctttgg gaggctgagg 377100 caggtgcatt gcctgaggtc aggagttcca gaacagcctg gccaacacag tgaaacccca 377160 tctctactaa aaatacaaaa agttagctgg gcacggtggc gggcacctgt aatcccagct 377220 actcaggagg ctaatgcagg agaatcactt gaacctggga ggcagaggtt gcagtgagcc 377280 aagatcgtgc cattgcactc cagcctgggt gatgagagca aaactccatc tcaaaaaatt 377340 tttaaaacaa aaggaaaaaa tgctcccctg attcccgcag tgctgactta aaatgttctt 377400 agtatgccaa tgttgcttaa atatgaatga ctgtagcttc tacttaaatt ggcaaccgca 377460 ccaaatataa actgcaaatg tttatagctc ttatggaagt ataaaagcaa aacaaattct 377520 taaattaaat acaaactaag agggaaactg ataataacaa tgttttgtgt aattaagttg 377580 ctgtttgcaa catgcctggg gcagactcct ggcctctttg catctgacat gagaggctac 377640 caaggatgtg gccacaactg ggctctccca gcacttgctt gcgctcagaa ctgtgccaaa 377700 acctttgctc gcccagtgtt ctgcaacgtc catcatttgg atttggcagg aacacatcat 377760 ttatgcattt tgtttgcttc tgtatttagt tgagatactt aaaatataac tgctagattc 377820 taaggcattc ataagcatct gtgaaaaatg tgttacttag gaaacagttc agggttccat 377880 ggattatcta gattggtgag tcttaagact gaccacacaa ttcatctggg ggtgtggagg 377940 aggggagctt tgagaaaaat ctctgtatga gcacccacac ccagagattc ctatgcaatt 378000 atcccagagt ggtgccttaa tatcaacatt tgtttaaaac catcccccaa gactaaaatt 378060 tgtgaccggg atttagaacc attgacttaa ttgatgcaga acactctgat attaatgtct 378120 tcatgtcttt tggaatgtca ttaagacaaa agcataaaat tttaaaattc ttaaagacaa 378180 tttaaagacc tatgagaatc catctttaat tctcaggagc gtgtggaacc tagtttgaaa 378240 actactggca tcgacaattg aatttccact aaaataaaat agctctctag tatattacaa 378300 aactacccat tctgcaaact gcaggggagc tactgataat gcttggaact gtgccaggca 378360 ctgcctgcat aaaaatgagt aaggtccact tcctccatgg actgggttgg gtaggaggca 378420 aagataatta accaattatt ttaatattat gagttcaggg ttgtaatgaa agtaagtatt 378480 gagtgctgca gagacccagc aaaggagtcc ttagctgaga actgatcctt tgctgagtga 378540 cgaggacatt attgaaccgc caggcttgat ggcatgttgc atggtaacag accagtacac 378600 caaacagcag gagctgtagc agagaaagag tttaataatt gtgtggcagc caaataagga 378660 gacagaagga aaccttaaat ccacctcttg aaaaagtctg ggactaggct ttttaagaga 378720 attctggcaa gaaggaggct gaggagctgg gggtaactga ttggttagga cataggagag 378780 gagacaataa ggatatagaa actccattct tgcactgggt cagttcctcg gagggggtcc 378840 tcactctggc tggcagcagt gaacccattg gaatgcagga tctgaaaaat atctcaaaat 378900 ggcaaacttg aggggttttt tttagcatca aagatgttat ctatagaagt taggacattg 378960 tgacaggggc tacgtgactt tgaagtgtta agtggctgtc agaaagtgag ctattgcagc 379020 ggtccccaac ctttttggta ccagggacca gcttcatgaa agaaaatttt tccacagatg 379080 gggtggtgta gggtggggtg ggggatagct tcgggatgaa actgatccac ctcagatcat 379140 caggcattag ttagattctc atgaggggca cacagcccag atccctcaca tgggcagttc 379200 acagtagggt tcacagccct atgaggttct aatgccactg ctgatctgac aggtggcaga 379260 gctcaggcag taatgcttcc ttgcccacca ctcacctctt gctgtgtggc tcagttcctg 379320 acagattacg gactggtacc agtttgcaac ccaggcagct ggggacctct gggctgtagg 379380 gtaggctggt taatgcttag ctgtgtttct attcaaagct tatgcttttg tttaaaacct 379440 agtaatttgg ttttgttaat tttatgaaga tgatttcaag gatgagtagg attagctgga 379500 gtcagaagga cacaagggaa tttctggcaa caacattaaa ctaccagtga atgtctcatc 379560 aagtcactgg acctctaatt ctaagcagta ctgtcaacct tataggttat gatgtataag 379620 atagtgttgt gatgtataag atagtgcaaa aacctaagtt aatatcacca tttctgtagt 379680 actctctatt tcaaaggaaa aaatcttcag cagtctaata tcctaccaaa attttgaagt 379740 caagacctcc ctacactaat caaagaacta gaggtgcaat caggccatat atttggaaag 379800 gccataggtg ccctccctct gtccttgttc ccagcatact aaactatagt ctaaaagact 379860 ttaaaacttg aactgaagaa aaccttaagg aaacaacaac aaaattccat ttatttcctg 379920 agcccaaaag tagaataatt gttttttaat gaatttttct ttccctgtaa gacatactat 379980 gaattgttca atgggtattc aaagcatatg taatagaata tgtatgcttt cctgaaaaat 380040 tgaaatggaa catcaaactg ttctgtaaag ttttgagtct agaccaaact cacagcactt 380100 agccagaata tgtacatctg catctgccac tcatggcccc atcgctccct ccaactgctt 380160 ctcttgggct gaaggatgga aaagcaaact ccctgcgttg agttccatct tgccctgcat 380220 ggcctccccc atggggtcat tgagctcccc accagcttcc acctcttcca gcactttccg 380280 ccagagggcc cgtggctgct tttgcagact gaaattgatt gtggttgatt cagctccatt 380340 tcctctgagt ttttacttta gatgtgcttt ttaggttgca tttttcttct ggcatataag 380400 aaagacagca atattccatg gaacagagtg atgtctgtgg ctttgtcaac cgttgtttgt 380460 tagcttgatc accatttatt gagtgtttac tactttccag gcattgtgct aagtggtaga 380520 aatacaaagt tgcctttact tgattcatct gtaaaataga gagagtagta gttcctacag 380580 tgtggtttat gtgaggcata gggactgctc cctgaaacct agggacaact ccctagcagc 380640 gacccagtgc tcatatcaat agtggtaaca attaggaagg cagctcctac ctcaaagacc 380700 tcatgatctg atggtaaaga cagatataac aagaaaatta ttctttttaa atataaaatt 380760 gtgatataaa aatagttttc actaaattgg atttttatga aatttacaga aacaaaataa 380820 taaattaagg aaatataaaa ccacctgaca ttagccaacc atgttgatgt tctgattatg 380880 ttactgcaaa ggagtgtagg gttaagaacg agggactttg attccaagat caaatccctt 380940 tctgctattt cttagctgtc tgactttggg caagttgctt aaaccctttg tgcttctgtg 381000 tgcttgccca tgagatggag attataatag cgtctacctc atagggctat ttttaataca 381060 agttagctct tagaacaata cctacttaaa ctaacaattt gtattaggta ctgttttatt 381120 ctccatccgt actgtgtatg catatattca tatttatatt tacatattct aattaggatt 381180 atatacatgt actttcttta aaaataagat tttaaataac tatataatca gtcatgatga 381240 tacaacatga tttattcaac aaatctgatg ctgttaaaca cgtaagtgat ttctctttca 381300 ggattataaa taacatttgt tttgcatttt tttcatacat cttttgctca cttttcattg 381360 ttactttgta tatgttgcta gaaattgatt tgctggtgaa aagggtataa acatttttaa 381420 ggctcttgct acatattgcc tgctcttcat acatattgcc tactgcccca ggaaactatc 381480 aattacactt ttaccaagag tgtatgaaag cattcacatg aatgtaacct tatcatgcaa 381540 tgcgggccat gagacagagg agagttatgg agggtagacg gcttccccgc tgctcagcca 381600 ctgccctctc ctctaaaaga gccacagtca ggaatttcta catagatcct attataaaca 381660 tctccttttg aaacaaatta tcttctctca gagcattttc ttcattttag tatctatata 381720 ggtccttgtt atgttcattt taagttttgt gacctgcact gacacaatgc tgatgaactg 381780 cttattccag gcagtctgag ttctcaaagc atttgcattt tatgtcttat cctctgtttt 381840 gggctctttg ccactgattt ttttttaagt gatattttaa gaaagaggag ggttgatttg 381900 ttgtgagtgt atctctcttt aaaaactttt ctagggaagg acaacctctt ccaaagactt 381960 tgtttgcttt gtgtgattgg catgtccttc cctggtcagt aatgagcttg aaggaagcta 382020 ctggacacgg gactgaacat ggggttttgc tatcactcta gctgtgcctt tctctagtga 382080 tcaaggagat gttggttcag aaagtgccct gtctaatccc actaaggccc gaaggaccaa 382140 gtgctgtcta ctctccagat tctctgcaac agaaagcaga tgcttaggct tcatggtcca 382200 ggttggaaca ggtagttagc tctgaggaca gttatgcatg aatgtcagga ggggactggc 382260 aggggaacat ttatttattc tttaaaattg gaatcaacag ttatggatga aacccagaat 382320 gcaaaattca ctttcatctt gacacgcaac acatctgtcc tttctccttg aatagcaagt 382380 attaatcatt gagttagaca atgtaacctt cacattcagt gaaagccaaa cactcagcac 382440 cttctagaaa aatcttagtg ccatgctttc ttagcatatt gcaagtcctc tgaggatgat 382500 gtgttgttca gctttgaagc tgatcttttg tacttgctta tgtagctcag gctagtgata 382560 acatgccaga ggcatttcca actaagaaaa ttattcacag aagctttaat tacaaatttg 382620 ttagccccac ttcctgctaa aatggccagc cttgaagagt ttcggaaatg tgagcagcct 382680 taaggatgat agaaatatta tgaaatagta ataagtaata cccatacagc aaactccttt 382740 ttctttggag tatccgttca tcagccagat ttccctctca acagtccagg tgttgacgaa 382800 gatcatgaaa taataggaat gaaagggact tcgattttgt atttttaata gcattttcct 382860 ccaccaaatt acgaaagtaa tgcatgacca aggcagagaa cttggaaaat acagaaaagc 382920 caccaagcaa aataatctcc caagaaatca taatttcacc acacaaaagt aaccattgtc 382980 aacattttgg tgaaaatcct taattaaaga gactcttaaa agatgccagt tcgctgccac 383040 ttcttccttt ctccacacca tcctgcaccc tgttttgaaa tgcagaattg tttctaaatc 383100 attccaggaa aattattagt tttctcaaat atctctggag gcgagtctgt tggcagtcat 383160 ttctagtttc tcacaaacct tgaagttagg aaattatttg tgtagctttt gagcactggg 383220 ccagaagtga gggatgtttg ggttctagtt ccagctctac cacttattta ccaactggcc 383280 gacctcaggc aagtccaggc tagcggcccc gcctcaagcc cctccagatg cagcatctgc 383340 aaccccactt ccttcacttc ctttcgcctc agtttcccaa caatttccta gtaattgtac 383400 tgaatcattg tttttcattt tttacattaa aatttattta ttttatttta tttttaaaga 383460 ctttattttt tagaacagat ttagatttgc agcaaaactg agtggcaagt acagaaagtt 383520 cccatatatt ccctgccccc gcacatacac agtctccctc actatcagca tccccaacca 383580 gagaggtaca ttggttacag ctgatgaatc tacatcgaca cgtcattatc acccaaagtg 383640 catagtttgc attggcgttg ggcattttag ggcttttgac acatgtatgc actattgtaa 383700 tatacagaat aatttcactg ccctaaaaat cctctgtgct cctcctattc attcctccct 383760 ccaccccatt cctggcaact actgatcttt ttactgtctc cacagttttg ccttctccag 383820 aatgtcatat acttggaatc ataaggtttg tagccttttc agattggctt ctttcactca 383880 gtgatatgca tttaaggttc ttccatgtct ttttatggct tgatagctca tttcttttta 383940 tcattgaata ctactactcc attgtctgga ttatacacac tttatttata cattcaccta 384000 ctgaaggatg tgttggttgc atccaagttt tggcaattat gaatgaagtt gctgtaaaca 384060 cccatgtgca ggtaattgtg ttgatatgca tttttaatgc ttttggataa acactcagga 384120 gcacaattgc tggattgtat agtatgttta gttttgaagg aaactgccaa accatcttcc 384180 caagtggctg taccattttc catttccacc aacaatgagt gagagttcct gttgctccac 384240 atcctcatca gcatttggtg ttgtcaatgt tctggatttt ggccattcta acaggtgtat 384300 tgtggtatct cattttgttt taattcgcat tttttggata atatcacatg gagcatcttt 384360 taataagctt atttgccatc tgtgtgtctt ctgtggtgag gtgtctgtta aactctttgg 384420 tccatttttt taatcaggtt gtttgcgttc ttatcgttga gttttaaaag ctctttgtat 384480 attttggata acagtcattt agcaggtatg tcttttgcaa atattttctc ccagtctgtg 384540 gcttgtcttc tcattctctg gagatcagtg gtttttacac tttcttctgc tgaagccaag 384600 tattgtggaa gaagccatgg ggtcaccaga ggataggtgc acagggtagt gagggaaagt 384660 tggagtgaat gggcttggtg cccccacccc gcaacatttc tcttgcttta atcagagaag 384720 tttgacttca tccagattgc atatgaggac tttacatgag gttcaccttt ttatttgttt 384780 taaaaggggt ttttactctc aaaatgtttt aaagaccact gaactagatg atcatcttaa 384840 ggccctttta agatttatga ttctggaatt ctgtggctct atttttccaa tgtaatataa 384900 ccttcctctc gttaaggaaa aatgagataa acctgttata aacactcatg tgacattttt 384960 tcaatacagt tttcatccac gtagtgctca cttagaatga tagaaacaat acacctaaag 385020 aatatgcacc attcacttgc ccactcatct ctcaaagaga ggaactttca acactagtta 385080 tctttttaaa aataatcaga gagaattctc agccacttca attctagccc aggaaaaaga 385140 gggaaaatac atttgaaggt ttctggctca tgtgatacat ttgcaaacca gaaccaagat 385200 gatatgactc tcatttatta gtgactattg caaagctttg caggctatta agcaggctgt 385260 tcaatttagg gtgatatgga catgtgcata ttggccaatt atatatgctc agatcgtatg 385320 tcattttttt tctgcatttt agtctaagtg tcagataggt gtttcatgat gttttataaa 385380 cacttctgtt cacattaaca ttgttcattg atttggcaag gaatgaaggg gtgtcatttt 385440 catgatttta tttgtatatt atgtattcca cagaggattt gaaatgcctt accaaatttt 385500 atgtaatgta aaggggtaaa ccaatatttg acacatcatt ataaattgag gataatctga 385560 agaaaataat aaatccagga gacagattat cacactgata tggtttggct ctgtgtcccc 385620 acccaaattt catcttgaat tttactcaca taatttccat gtgttgtggg agggacccag 385680 tgggagatca tttgaatcat aggagtggtt tcctccatgc tgttctcatt gtagtgaata 385740 agtctcatga gatctgatgg ttttatcagg ggtttccact tttatatctt cctcattttt 385800 tctcttgcca ccaccatgta agaagtgcct ttcgcctccc accatgattc tgaattctga 385860 accctcccca gccatgtgga actgtaaatc caattaaacc tctttttctt cccagtcttg 385920 ggtatgtctt tatcagcagc acgaaaatgg actaatacag taaattggta caaggagtgg 385980 ggtgttgctg aaaagatagc cgaaaatgtg gaagcaatct tggaactgga tatcagggag 386040 aggttggagc agtttggagg gctcaaaaaa gacaggaaaa tgtgggaaag tttgaaactt 386100 cctagagact tgttgaatgg ccttgacaag aatactgata gtgatatgaa caataaagtc 386160 caggctgagg tggtctcaga tggggatgaa gaaactgttg ggaagtggag caaaggtgac 386220 tcttgttata tcttagcaaa gagactggtg gcattttacc cctgctgtag agatttgtgg 386280 aatttgaact tgagagaaat gatttggggt acctggtaaa agaaatttct aagcagcaaa 386340 acattcaaaa ggtgacttgg gtgttgttaa aaccattctg ttttaaaaga gaaacagcat 386400 aaaagttcag aaaatttgca gcctgatgat gcagtaggaa agaaaaaccc atttttttga 386460 ggagaaattc aagctggctg cagaaatttg cataagtaac aaggagccaa atgttaatcc 386520 ccaagacaat ggggaaaatg tctccagagc atgtcatagg tcttcatggc agcccctccc 386580 atcacagacc cggaagccta ggaggaaaaa aacagttttg tgggccagtc ccagggtccc 386640 catgctgtgt gcagcctagg aacttggtgc cctgcatctc agctgctcca gctattgcta 386700 aaaggggctg aggtaccacg gtttcagagg ttgcaagccc caaaccttgg cagctttcat 386760 gtggtgttga gcctgtgtgt acacagaagt taagaattga ggtttgggaa cctccactta 386820 tatttcagaa gatacgtgga aatgcctgga tacccaggca aacatttgct gcagaggtgg 386880 ggccctcatg gagggcctct gctagggcaa tgaggaaggg aaatgtgggg ttggaacccc 386940 cacacagagt ccccactggg gcactgccta gtggagctgt aagaggagga ccactgtcct 387000 ccagaccgca gaatagtaga tccactgaca gcttgcacca tgtgcctgga aaagccacag 387060 acactcaacg ccagcctgtg aaagcagtca gggttggagg tggtggtggc tataccctat 387120 aaagccacag gggcagagct gcccaagact atgggaacct acctcttgca tcagcatgac 387180 ctggatgtga gacattcagt caaaggagat attttgaagc tttagaattt gactgccctg 387240 gtggatttta gacttgtgtg ggccctgtaa cccctttgtt ttggccaatt tctcccattt 387300 ggagctgctg tatttaccca atgcctaaac ccgcattgta tctaagaagt aactagcttg 387360 attttgattt tacaggctca taggcaaaag ggacttgcct tgtctcagat gagactttgg 387420 actgtggact tttggttaat tctgaaatga gttaagactt tgggggactg ttgggaaggc 387480 atgattgctt ttgaaatgtg aggacatgag atttggagag gccaggggtg gaatgttatg 387540 gtttggctct gtgtccccac ccaaatctca tcttgaatta tactcccata attccaaagt 387600 gttgtgagag ggacctggtg ggaaacaatt tgaatcatga ggccagtttc ccctatactg 387660 ttcttgtggt agtgagtaag tctcacgaga tctcatggtt ttatcagggt ttccgctttt 387720 gcatcttcct cattttctct tgctgctgcc atgtaagaag tgcctttcac aagcataagg 387780 aagaagtata cttgctggag cagcaggctg tccttcttct gacgatatgg actgcaagtg 387840 cctatgttta ctttgaccaa gacggccttt cttttcacag aaagccaggg ttcacccctt 387900 gaatttcata agacctctct ttgcagtggg ttagatactc ttttatattt ttatactctg 387960 tcaggaaaac attttttttt ccatttaaaa atcagtcttt tggttgcttc caagatggct 388020 gaataggaac agctctggtc tgtagctccc agcgagatcg aagcagaagg caggtgattt 388080 ctgcatttcc aactgaggca cctggttcat ctcactggga ctggttggac agtgggtgca 388140 gcccacggag ggtgagccga actggggcag ggtgtcacct cacccacaaa gtgcaagggg 388200 tcaagggatt tccctttcct agccaaggga agctgtgaca gactgtagct ggagaaacag 388260 tacactcctg acaaaatact gcacttttcc ccacagtctt gacaactgga agaccaggag 388320 ataccctccc ttgcctggct cagtgggtca cacgcccatg gagacttgct cactgctagc 388380 gcagcagtct gagatcaacc tgcaatgctg ctgcttgatg cggggagggg cgtctgccat 388440 tgatgaagct tgagtagctc acagcgtaaa caaagcagca gggaagcttg aactgggcag 388500 agcccacctc agctcagcaa ggcctactgc ctctctagat tccacctctg ggggcagcac 388560 atagcagaac aaaaggcagc agacagcttc cgcagactta aacatccctg tctgacacct 388620 ctgaagaggg cagtggttct ctcagcacag tgttcaagct ccaagaacca agagaccgcc 388680 acctcaagca ggtccctgac ccccatgtag cctgactggg agacacctcc cagtaggggc 388740 cgacagacac ttcaaacagg caggtgccct ctgggacgaa gcttccagag gaaggatcag 388800 gcagcaatat ttgttgttct gcagcctccg ctggtgatac ccaggcaaac agggtctggg 388860 gtggacctcc agcaaactcc aacaggcctg cagctgaggg gcctgacggt tagaaggaaa 388920 actaacaaac agaaaggaat agcatcaaca tcaacaaaaa ggacatccac accaaaaccc 388980 catctgtagg tcatcaacat caaagaccaa aggtagataa aaccacaaag atggggagaa 389040 accagagcag aaaagtggaa aattccaaaa accagagcgc ctcttctgct ccaaaggatt 389100 gcagctcctc accagcaagg gaacaaaaca ggatggagaa tgagtttgat gagttgacag 389160 aagtaggctt cagaaggtcg gtaataacaa acttctccaa gctaaaggaa catgttctaa 389220 cccatcgcaa ggaggctaaa aaccttgaaa aaaggttaga tgaatggcta actagaataa 389280 acagtgtaga gaagaactta aatgacctga tggagctgaa aaccacagca tgagaacttc 389340 gtgatgtatg cacaagcttc gatagctgat ttgatcaagt ggaagaaagg atatcagtga 389400 ttgaagatca aattaatgaa ataaagtgag aagacaagat gagagaaaag aagagtgaaa 389460 agaaacgaac aaagcctcca agaaatatgg gactatgtga aacaaacaaa tatatgtttc 389520 attggtgtac tgggaagtga tggggagaat ggaaccaagt tagaaaacac tcttcaggat 389580 attatccagg acaacttccc caacctagca aggcaggcca acattcaaat tcaggaaata 389640 cagagaacac tacaaagata ctcctcaaga agagcaaccc caagacacat aattttcaga 389700 tttaaaaagt atgaaatgaa ggaaaaaatg ttaagggcag ccagagagaa aagtcgggtt 389760 acccacaaag ggaagcccat cagactaatg ggatctctca gcagaaaccc tacaagccag 389820 aagagagtgg gggccaatat tcaacattct taaaaattct taaaaaaaga agaattttca 389880 acccagaatc tcatatccag ccaaactaag cttcataagt gaaggagaaa taaaatcctt 389940 tacagacaag caaatgctga gagattttgt caccaccagg cctgccttag aagagctcct 390000 gaaggaagca ctaaacatgg aaaggaacaa acagtaccag ccactgcaaa aacattccaa 390060 attgtaaaga ccatcgacgc tatgaagaaa ctgcatcaat taacgggcaa aataaccagc 390120 taacatcaga atgacaggat caaattcaaa cataacaata ttaaccttaa atgtaaatgg 390180 gctaaatgct ccaattaaaa gacacagact ggcaaattgg ataaagagtc aagactgtgc 390240 tgtattcagg agacccatct cacgtgcaaa aatgcacata ggctcaaaat aaagggtcga 390300 aggaaaatct actgagcaaa tggaaagaaa aaaaaaagca ggggttgcaa tcccagtctc 390360 tgataaaaca gaatttaaac caacaaagat caaaagagac aaagacagcc acaacaagaa 390420 gagctaacta ccctaaatat atatgcaccc agtacaggag cacccagatt cataaagcaa 390480 gtccttagag acctacgaag agacatagac tcccacacaa taataatggg agactgggag 390540 acaccccaca gtcaatatta aacagatcaa caagacagaa ggttaacaag gatatccagg 390600 acttgaactc agctctagac caagtggacc caatagacat ctacagaact ctccacccct 390660 aatcaacaga atatacattc ttctcagcac cacattgcac ttattttaaa attgaccaca 390720 taattggaag taaaacactc ctcagcaaat gtaaaagaac agaagtcaca acaaactgtc 390780 tctcagacca cagtgcaatc aaattagaac tcaggattaa gaaactgact caaatccaca 390840 cagctacgtg gaaactgaac aacctgctcc tgaatgacta ctgggtaaat aacaaaatga 390900 aggcagaaat aaagatgttc tttgaaacca atgagaacaa ggacacaatg taccagaatt 390960 tctgggacac atttaaagca gtgtgtagag ggaaatttat agcactaaat gcccacgaga 391020 gaaagcagga aagatctaaa atcgacaccc taacatcaca attgaaagaa ctagagaagc 391080 aagagcaaac aaattcaaaa gcaagcagaa ggcaagaaat aactgagatc agagcagaac 391140 tgaaggagac agagacacaa aaagccgttc aaaaaatcaa tgaatccagg agctggtttt 391200 ttgaaaagat caacaaaatt gatagaccac tagcaagact aataaagaag aaaagagaga 391260 agaatcgaat agatgcaata aaaaatgata aagggatatc accaccgatc ccacagaaat 391320 acaaactacc atcagagaat actataaact cctctacgca aataaactgg aaaatctaga 391380 agaaatggat aaattcctgg acacatacac cctcccaaga ctcaaccagg aagaagttga 391440 atctctgaag acaccaataa caggtactga accaaggttt ggaccaacca aaaatgtcca 391500 ggaccagatg gattcacagt tgaattctac cagaggtaca aagaggagct ggtaccattc 391560 cttcagaaac tattccaatc aatagaaaaa gagggactcc tccctaactc attttatgag 391620 gccagcatca tcctggtacc aaaacctggc agagacacaa caaaaaaaga gaattttagg 391680 ctaatatccc tgatgaacat cgatgtgaaa atcctcaata aaatactggc aaaccaaatc 391740 cagcagcaca tcaaaaagcc tatccaccaa aaccaagtca gcttcattcc tgggatgcaa 391800 gactggttca acatacgcaa ataaataaat gtaatccatc acataaacag aaccaatgac 391860 aaaaaccaca tgattatctc aatagatgca gaaaaggcct ttgacaaaat tcaacagcct 391920 ttcttgctaa aaactctaaa taaattaggt attgatggaa cgtacctcaa aataataaga 391980 gctatttatg acaaacccac agccaatatc atactgaatg ggcaaaacct ggaagcattc 392040 cttttgaaaa ccagcacaag ataagaatgc cctctctcac cactcctatt caacatagtg 392100 ttggaagttc tggctagggc aatcaggcaa gagaaagaaa taaagggtat tcagttagga 392160 aaagaggaag tcaaattgtc tctgtttgca gatgacacga ttgtatattt agaaaacccc 392220 attgtctcag cccaaaatct ccttaagctg ataagcaact tcagcaaagt ctcaggatac 392280 aaaatcaatg tgcaaaaatc acaggcattc ctgtacacca ataatagaca aacagagagc 392340 caaatcatga gtgaactccc attcagaatt actacaaaga gaataaaata cctaggaatc 392400 caacttacaa gggatgtgaa ggacctcttc aaggagaact acaaaccact gctcaacgaa 392460 ataaaagagg acacaaacaa atggaagaac attccatgct cgtggatagg aataatcaat 392520 atcacgaaaa tggtcatact gcccaaggta atttatagat tcagtgctat ccccatcaag 392580 ctaccattga ctttcttcac agacttggaa aaaaactact ttaaagctca catggaacca 392640 aaaaagagcc tgcatagcca agacaatcct aagcaaaaag aacaaagctg gaggcatcac 392700 gctacctgac ttcaaaccat actacaaggc tacagtaact aaaacagcat ggtactggta 392760 ccaaaataga tatatagact aatggaacag aacagaggcc tcagaaatga caccacacat 392820 ctgcaaccat ctgatctttg acaaacctga caaaaacaag aaatggggaa aggattccct 392880 atttaataaa tggtgctagg aaaactggct agccatatgt agaaagctga aactggatcc 392940 cttccttaca ctgtatacaa aaattcgctc aagaaggatt aaagacttaa atgtaagacc 393000 taacacctag aagaaaacct acacaatacc attcaggaca taggcatggg caaagacttt 393060 atgactaaaa caccaaaagc aatggcatca aaagccaaaa tagacaaatt ggatctaatt 393120 aaactaaaga gcttctgcac agcaaaggaa actatcatca gagtgaacag gcaacctaca 393180 gagtgggaga aaatttttgc aatccaccca tctgacaaag ggctaatatc tttgtagaat 393240 ctgcaaagaa cttaaacaaa tttacaagaa aaaaacaaac ccatcaaaaa agttggcaaa 393300 ggatatgaac acctttacac tgttggtggg agtgtaaatt agttcaacca ttgtggaaga 393360 cagtgtggtg attcctcaag gatctagaac tagaaatacc atttgaccca gtgatctcat 393420 tagtgggtat atacccaaag gattataaat catgctacta taaagacaca tgcacacata 393480 tgtttattgc agcactattc acaataccaa agacttggaa ccaacccaaa tgtccatcaa 393540 cgatagactg gataaagaaa atgtggcaca tatacaccat ggaatactat gcagccataa 393600 aaaaggatga gttcctgtcc tttgcaggga cgtggatgaa gctggaaacc atcattctaa 393660 gcaaactatc atgaggacat aaaaccaaac actgcatatt ctcactcata ggtgggagtt 393720 gaacaatgag aacacatgga cacagcacaa ggaacatcac acaccggggc ctgtcagggg 393780 ttggggggct gggggaggga tagcattagg agaaatacct aatgtaaatg atgagttgat 393840 gggtgcagca aaccaacatg gcacatgtat acctatgtaa caaacctgca cgttgtgcac 393900 ctgtacccta gaacttaaag tataataaaa aaaaaagaaa gaaaagaaaa gaaaaaaaga 393960 agtggctttt acctcccacc acgattctaa ggcctctcag ccatgtggaa ctgtaagtcc 394020 agttaaacct ctttttcttc ccagtctcga gtatgtcttt atcagcagcg tgaaaatgaa 394080 ctcatacaca cacacagaag tatatcttta cagttcccag gatggactgc aagtttggct 394140 ctaaatttcc tttgcctggc caaaacaaaa agaacacatt ttattataag gttcacaggc 394200 ttttaattga aaaaaaaaaa aaaacagtta ttcaacatga aaactctttt tcagacaaag 394260 ttctacaaag tctatttctc acaagtagga ctttggcaag gattgtgcaa ctgacaattc 394320 aaagtcattt attccgtggt gagaaaccgg agtacagatc tttaccagtt aggggatgat 394380 ccatgtgttt tgataatcac cttggtggtg atcagactaa aggtctccta tgaaaaccat 394440 taacttcaca ctatagctga taggatgcac tgaagccctt accgctgact gcatggatga 394500 gagctaggcc agagcattgg caggcagagt ttataacatg gggcaggaag cattgaaatt 394560 ctattccacc tcttggtgta tcaggtcagg agtcaaatct cctatcttcc tcttctggat 394620 cgctttcctc ctgaagtgtc tggcatagat gtctaggtat agcttggcat ggtggtgtgt 394680 gcctatagac ccagctactt gagaggctga ggtgggagga ttgcttgagc gcaggagttt 394740 gaggctgcag tgagccatga ccacaccact gtactccacc ctgggtgaca gagcaagacc 394800 ctgtctctct ttctaaaaaa acaaaacaaa acaaaacaaa acaaaaagaa aaaaagatgt 394860 ccaagtgtgt tctggttact gctgctgact gctaaattta acagctagaa aaaaaaagtt 394920 tggactctat ggatcataaa tttggataag acacagaggg aatggcttgt ctcatgttca 394980 caatgtctaa agtcttaaat ggggagagtc gtcaaccagg ggtaatttga gagttatggg 395040 ctggaaccac cttgaggcat ctttattcat aggctagcaa ttgatgttgg ctgttggctg 395100 ggacgtcagc tggagctgtc aactgggaga cctgtctgat atcccagcat aggacactag 395160 acctctcaca aagtggcgag ggctccagaa gcaagtgtcc cagctgacaa aaaaaaaaag 395220 tttcatagcc ttctacgaca tgcacttaga agtggtaatg tgtcacttcc agccctttct 395280 gttgattaca agtgagtcat gagtccactc agtttcaagg gagagggccc agatcccata 395340 tctccatggg aagagtgcca agaacacctt gtagaaaagc ttgtggatag gagatattgg 395400 tgtggtcatc cttggaaaac acaatcttcc acagtgtgca agagaggctt cctgctctgc 395460 attgtggctt aattattgtt gaaataccag gcaagaaaag gtaggatcca gggaaacaaa 395520 tgtatccagg atgttttggt ctgccttttc taggaaaaaa ggaaaccctc aaagcctctg 395580 agactaggtc accccagtgg gactagaagt tccacgtgga accttctgca aactcctctg 395640 caatagatgg actgtgcatt ttccaaatgt gtctttacat catctccttt ctgaccttgg 395700 gaagatagta actgactgtg gagtaggaaa tccagaaccc tgattgtttt aaaatatatt 395760 acagatacaa gtaatgaaaa gaaggctcct aaggaaaata tagatccgta atggctttgt 395820 cccaaaagct attaggctat aatattttat tacaaaggct atatttatta caaaatgtat 395880 ttaaataaat acttaatatt tatttaaata aataatattt attttattat taataattaa 395940 tatttaaata aatataatat ttcttacaaa aattaaaaac tgggacttta tatttaaagg 396000 tgagacatta aattcttttt aaaaagtgca catgtaagat ttttttctca agtcaactga 396060 accagttcat cagtttcact atgaatgtgt tgatgcacca agtatttact ttctagaaca 396120 tctagtagac gtcactaaaa aattatacca agttgaaaaa tgtcactgaa tcagaggcat 396180 gtggttggtt atgtagtcat ctgtgccagc tgggaatata gcaataccaa atgaacagca 396240 ctgccatgtt cccttgctgg gttccagcaa aaacactcat cttcactgtc gtctctcttt 396300 gagacctctt agagaggact ttgatgagtg tatggtctta tacacactag tctaacaata 396360 cacatttgct caaggattgg gttacgagca ggctcttcac ctttcaggtg aacaattaca 396420 catcaggaga aggatggaag tttcctatct atgaacaaat atttcccaaa gcaataatct 396480 ctttattcaa ctcacgtaat gagaagtcag ttcctctgtg ccataaagca atctctttga 396540 agtcttcagt aatgttgagg gttttaatgt tgagggcttt atcaaactaa acattcaagt 396600 gtcttaggct ttccccttag ttctttgagc aaattggttg ctatgaagta tgttagtgtt 396660 ccgaatgaat ggatagcatg atgggggatg tctaggtggt tccagaattt agattgtggt 396720 ttccataaca aagtgtggca gtattggcat tagggaagag aaatgacttc taaataactt 396780 ctcaaagttt actaaagcct taagaatgta ggaaatggcc acaaaaggag gtatacaaaa 396840 cattcctctg tctttattcc tctttataca aacgtattca ctttcccatc agcaagtcat 396900 aaaatacttc tcatcttgca ttacagtagg acacctacta taacaatagg ctacaaaatg 396960 tataatggct caaacaccta gcagtttatt tcttatttac ttaacaatgc tgggtccacg 397020 aacatgttga tatcataacc ctcttttatg tggtcactca gggactcagg ctgttgaggg 397080 ctctgtcatc atgaatgggt ggcttccaag gtcatcctaa gagttatctc cattctaacc 397140 agtccagcca gaaaggcaga acaggcttgg aggagcaaag atatccatgg atagatcatc 397200 ctcttaaagt cattgtagca ttgtgatagg gctcttttca caaaacaagg atacaatcca 397260 tgttttcaag attttacatt ttagtagcca caatacaaag aagctaagat agtcttgtga 397320 tttgtcatca tggctgttaa tggagagtgt tttaaaagca ctgatatcag ggctccaccc 397380 tcagcttcca atcatcaggt ttggatggaa cctgacagct gcatcttgta aaactccacg 397440 ggagattctg agagacagcc aagtttgaga ttcacaaacc ttaagagaaa aaatctcctt 397500 gaattgccat aacaaactac cagtctaata aaacatacat attcctttga ctactcttaa 397560 atgaaacaaa taggtaataa tttacctgta catataatta aaaatgtaat gtattttata 397620 accatcatat aaaggagaaa ttatattaaa ctatattaaa ataaaatgat atatatttca 397680 atgcagatgc ccaagcttga ctaaagtagg aaacataata aagtaataaa atgcttatat 397740 gtacttataa tgaatgtttg gctatgagaa gatgatcaga ggctttttgt ccaagaagta 397800 caggcatatg aaaaagtaga gcaagagatg gacaccagac tgagaaaact aaaaactaac 397860 caacctattt gtgtatgata aaaggagaga aaaaaaattg attagtaaaa atatgctacc 397920 gtgtggtctg aatgtttgtc ccttccaaaa ctcatgttga aatttaatcc cccatgtggc 397980 agtattgaga agtgggacct ttaagaggtg attggttcaa gaagattctg cgctcatgag 398040 tggttgaaac cattcacgga ataacgggtt aatggatcaa tgagttatcc caggagtggg 398100 actggtagct ttataagaga aggaagagag acctgcgcta gcacactcag cctccttgcc 398160 atgtgagcca tctcgggacc ccgcagagtc cccagcagaa agaaggccct cacccaatgt 398220 gtccccttga cctaggattt ctcaacctcc ataactgtag gaaatgaatt ccttttcttt 398280 gtaaattatc cagtttcagg tattctgtta taaacaacag aaaatgggct aaaacacacg 398340 ccaagaaaat tgaaagactg tggaagtgaa agaagaataa aaaatgaagt aattttgcaa 398400 atgagtctgg ctttattata agtgtattgt caaagtgatt ccctttgtta taagatgaaa 398460 aagagccaaa atggatagaa acatttatcc tatcttaata tcccactaca ttcaaggcaa 398520 atattcagtc agtctctaga acttaacaag gccttggaga tgatatcctt tggatgagca 398580 atggagaaga caagatggat tggaaaaaga aacaaacaaa caaaaaaaca tgtaagaggc 398640 tatcaggaaa actctggaga cgatgtcaat gtaaaacaga tacaaacctc aaaataattt 398700 taatatgtac attgcacaaa aatggacttc ttatcatgtt acaaatttat tttaaaacat 398760 ataggaggca acaacaatat ttcattgatg tgtactattt tataattgtt ggctctaatt 398820 ttatttagta gagtcttaca tctcctctct acatatttac atccggttgt attgtttttg 398880 tagtacctgt tcaactgcac tgaaatcatt tcaattaaat gcatggttga aaagctgaca 398940 taatacattc aattgccaaa ttgcataaag tgaataagct atttaataat ttggagaaaa 399000 tatattccat ttaaacttcc ttctctataa ccagttcata cactggacct tttgggcaca 399060 gccatgtgaa agcttttcaa aacttttcac tacttttttt tgagacggag tctcactctg 399120 tcacccaggc tagagtgcag tggtgcgatc tcggctcact gcaacctcca cctcccaggt 399180 ccaagtgatt ctcctgcctc agcctcccga gtagctggga ttacaggcac ctgacaccac 399240 acctgactaa tttttgtaat tttagtagag acaggatttc accatgttgg ccaggatggt 399300 cttgaactcc tcatctcaag tgttccgcct gccttggcct cccaaagtgg tgggttacag 399360 gcatgagtca ttgcacccag ccactataga tttttatttg tagtagattt agttcagtag 399420 ggcatttgag aggcatagga actggaacaa atccttcatt gtttgggact gccttgcaca 399480 ttgtaggaca tccagtacag tcccttccac gaagtggcag cagcagcctc gggctgtcca 399540 aacaccctgt tagggacagt gccactcccg gaaccacaga agaaccacaa tcataggaga 399600 agcatacaac aaacatggtg ttcatcggac ggtcagcttc agtggcactt ttgagcaagc 399660 acactatttg gttgtagaat gagtccctgg cagggcaccc gaaaggctga tgtgtgactc 399720 atccctagta cctctgagaa tgctgaaatc tcctccttct ccaagctgag tggcagcttt 399780 ctggtccaga ctacttaaat tgtgacttga ggaattttct tcactttttc ctttgagtca 399840 ttctgttttt gatcaagatg cgatagaatg aaggattctt tcagggtctg ctgtcacatc 399900 cttcctttgg gaacagatag aaaatctggc ctggcttgaa gagtttgtcc tcaaacatct 399960 ggtaagccat aggcatcagc atctcttact tctccagaga catttagatg tgtcccccat 400020 ctccatggag gcccatggca aggggacccc tagttgtact agagcttcct tctgggcaca 400080 gccacactgc acaggcactg cagtgtacag cacagctcct ccagcttccg gaagactcca 400140 ttatctagaa aagtgctgag aaatggagaa gggggttcct ctggggtgga gatggaaaga 400200 ggaaaaggaa gggagaatgt ccaagcaaaa tgagagaagg tgagggacag cagaattgag 400260 agtgagggag agggagagag caagagactg ggttgagatg tcttgtacat gggggtgtcc 400320 tcgtggcttc actccccttt cgtttgtacc actccgtttc cccagactct tcctaaatat 400380 ccccttattg gctacaagat ccagattgcc tagaagctca gatttgctga cagcacctca 400440 agactggtta atgacatata gattttttct tgtttccatc tttgggattt ggagcaatct 400500 ccagagttgc aaaagcctac cttgttgcaa taatattttt gagggtccac actgtctgct 400560 cacttgctct atgctgctgg gcacagtggt gtggccatcc agggtgggag agaccacctg 400620 ggatatggaa attaccagca gccctgtttt gctcttgcag tggttgccaa agcacacgaa 400680 gcattctggg aatctgaatt tctgttgttt ctcccaaatg gcccctgaag ggcaacaggc 400740 agcacacatg gaccacattt tgccagaaaa gtccagaaag aagatggctg ctgttgtcaa 400800 ctattggcat ttcaacagga cctattttta tttctcagta tatttgcaca actaggaagc 400860 atctgctgac aaggatgaga tgataagctg tattgatgcc aaaacaggac tagaaaaaca 400920 ggcttgttct gcaaatggcc tgcatcctga gagtccgtgt taagaacatt ctctctctgc 400980 aggcaatatc tgctcttaaa acattaacac ttgaaaggaa gtaaggcttg gaatccttag 401040 catagttatg cacacactag gttctcagta agtgcatgct ggatgaagga acccacacgc 401100 accttaagga ggatggaaca ttggcagccc aagaaaaaag tcactcccca gaggccgagt 401160 gccatgtctt tgacctccat tggcaaggtc atggtgaaat gctgtctctt ggggtcgctg 401220 aggtcccagc acggtgtgcc ttcacaccgt gcaaacaata agaagagaag agaggcacac 401280 atgtcacctt tccaggcagg gacatccaag ctgtttgagt ctccattctg tgatttcctt 401340 gaacaagaaa gggattattg gtgaatgagg ccagcatcct gggtgggaac aaaaaaggaa 401400 attggtagaa agtacatcat ccaagttggt ctaactcagc cctgtggctt gggcgggttc 401460 ctaggatatc cagccggagg cagaggctct aggggatgtg aggctgcact gggtatgatg 401520 acacagagga ctgtgagagg cagagaaaag gggagaagag ctgaggccct cctagcccta 401580 acctcccagc tcacaccctc tgctatctgc cacctccagg ccaacaccac ggccatggga 401640 ggtttgccca tttttctgat agacacattc tttctctacc aacagcccac atggaacata 401700 agtgaagtaa ttcagcagtt tccttcttaa tctgctgtct ctctgctgct tactcattct 401760 gtgctgtttg ctttagatca aggtgcccca gggtaccaaa agctacatta tcctattcaa 401820 ctgcatggaa accaagatcc cgaccattct ggtttgttgt tattgttacg ttagttttaa 401880 accttagcca ttttccattc tgggcagtta caactctgtt tactatgagt tcctctgtgt 401940 agatgtttct cccatacccg acctacaaac tgctacgtga gcagtaactt gtcaccatgt 402000 tatccgcata aagtcaggga ttgataaact tgggagcctt tagctcttga aggtgctgat 402060 gaggaagggg agaggggagg agaaggaatt tgtttgtgag atggtcagtg ggctgaatag 402120 tggtatgacc aaaaagtgtt actataaata cacataatct ggaaaacaaa aatactgtca 402180 tctcctccct gcaaggcgct gtgattaggc aggatggagc ttattgctgc agtgttagaa 402240 aatgcatcct tgtagtccca aaaaagcctg ttccatcctg cccatctctt gttctcaata 402300 cttcttactt cacggtcact cattttcttc ctgtccttgg gttgaggtct caacttcttg 402360 taatagaatt ttttcagtta taagcgacag aaatccaact cacactatct taagcaaaaa 402420 ggggattcac tgatacgtgt gttaggaagg atatatgaaa gctcaaaggt caagtgaaaa 402480 aaatgtaaga acgaagacct tggtggggtg tggtggctca cgcctatcat cccagcattt 402540 tgggaggccg aggcaggtgg gtcacaaggt caggagttca agaccagcct gcccaagatg 402600 gcgaaacccc atctctacta aaaacacaaa aattagccgg gtgtggtggc aggctcgtgt 402660 attcccagct acttgggagg ctgaggcaga gaactgttta aacctgggag gcagaggttg 402720 cagtgagttg agatgtgcca ctgcactcca gcctgggcgg cagagtgaga ctctgtctca 402780 aaaaaaaaac aaaaaaaaaa aactaagacc ttgtgactac tacctactac ctggatctct 402840 ctctctctct ctctctcttt ctctctctct ctctcacccc cccacactat cacctctcct 402900 tgttgtcagt agtttccttt ctgcagacag gagttccatg tgctgggaag agggccattc 402960 agagcctcgt attctcatcc tctcagttta gcaatgcgag aagaaaaaac ttttgtctca 403020 caacctcata tacaatctca gaaataggct cttattttct ggcttgaggc tgtccagagg 403080 caccaggcac tgtgatggtc tcactttctg tcctggatct atctgtgggg cccagacagc 403140 aggatctatt tcagaaaata ggcgagagag gaaaaactta tgtggccgta aaaaacagcg 403200 gttttcaagt ggcctatccc catccacatc ataaactttt ctgctgaggc ttaaaagtgc 403260 ttagacttca aacttgatct aaaacagaaa tcctacctgg aaaaatcacc ttccagtcac 403320 ttagccaatc gctcatcact ctctgtctct gaatctcacc acgagtttca cacgtctccc 403380 gagagagcgt ctcctttatc attaccacat gtggagtcag cagattgggt ttcatctaag 403440 ctctgcctac ctactatccg agttccctag caggttagtg actttctctg cctttttgtt 403500 tcttgatgtg aaaaggaaca acagtggctg ctcacagggt tgtcagttac atggtcaatt 403560 acattacatg gacaattcat gatggtgtca gacctgtctg agaaaaggtg gcccatgtta 403620 ccatgacagg ccccaaggct aacagcccct ttctgggtca tggctcatac aaaggagccc 403680 tccttggttt gctggtgctc tgagacttgc aaatgcatta ggaattttac actgtaaccc 403740 ggttttaaat gggtccagag catccccatt gctagactac tgtgctgagg aagggcactg 403800 gctcattgtt acatcccatg aacactctgg gtctcctaga cctcatcctc tttgagcttc 403860 tctctctcac tctctctctg cgcattcagg agtgtacaca tttctgtcca gcaccctgaa 403920 gtctctggaa gagaaggacc atatccaccg agtcctggac aagatcacag acactttgat 403980 ccacctgatg gccaaggcag gcctgaccct gcagcagcag caccagcggc tggcccagct 404040 cctcctcatc ctctcccaca tcaggcacat gaggtgaggc atctgtgggc ttcctacagg 404100 agagacataa agaaaacatg cccccaaacc tatgtgacag ctggccggga aggactggtg 404160 cctgcatatg gagagtgcac ttgtgacagt tcctggcata gaataagcat aaatgctata 404220 ggaggacaga agagagaggt tttaaatctg cgagggtcac agggcaagtg tcagagaagg 404280 catagaggaa gcgatactta cgcttggttt aaagcatgtg ctttggggca gtggtttaga 404340 gattgggtgc agtgtgcaaa taggaggagg gggccaatca agagaagtca gtgaatgtac 404400 acatcccctg aagacactgg gtacatctgt tatggtccct gtgtacactc ggatattcta 404460 aatgagagac cctggggcca gatgcctcac ggagagtcaa tgttgactcc ttcatacctg 404520 ttgaacccct tcttgtcacc cccattgcca ttaccctagt ctaagccacc atcattttct 404580 gttggacttc tgtgccagtc actggatgtg tatccctgcc tgtaatctag atcctttcta 404640 gatcattctc catgatgtgt ccagagtgat cattctagaa ccaaatctga tgtcatcctc 404700 ctgcttaaaa cccttaagtt ctcattgctt ttagataaaa tataaaccct ttcactttgt 404760 ttttattact ccttatgatt cagcccttac ttagcttaca aggacttcct catgtctgag 404820 ctctagccat aatagctgac tgttggatga gtcatcgggg ggaggttctt cttcaggctg 404880 cagattggcg gtcagccctc ctgacctcag ctgggctcac tcacacatct gggaggcagc 404940 tgcctgaggc cagggtgact ctgctctatg cctcatgtct cctatcctcc ttgtacccac 405000 atgttagctg ggacatgttc tcatcgcaat ggcagaggca tgagaaagtg atcctgtttg 405060 ggcaagtgca ttttactctt ttctttcact catgtccact gacatttcat tggccaagca 405120 agcatgtggg gtgtccagag tcaaagaggg acatgttgcc ggggtcatga ctatttctga 405180 gcaataatct aacctatcat agctcagatc tcactccttg caggaagcat ctcctaatcc 405240 ttaagaccta gttggaactt acactctgtt cttccctatg gttactgccc attttactat 405300 ttttctgccc atttagactg acaactctgt gagccatcat tgcaatatgg cttgcttacc 405360 caatatcacc tagcatgatg tagagcacat agtaaatact caacaaatgt tttctgtaag 405420 agctaaggaa ggacatcagc agacaaaata gagtctttct atgccaaaag gtgaaagtgg 405480 tctcatttcc attccattgt cctgtaattt ggctagccaa aagcttagtg gataccattc 405540 ccataagtag acctcatctg cagggaagag atggggagac tgctgggtta tttattgcag 405600 actccagcag gaccacaaca atgattcaaa gtgatgacac tagaaggaca ggtgccaatg 405660 ggtgatgaag ccacaatgac gatgtcaagt ggtatcacta aaaggacagg tactcatggg 405720 tgatgaagcc tacatgacct tgggcttaca ccaggaccct aggaatgaaa gagattcctt 405780 ctcttagtgg ctatgaggga aggcctatga tgtcttaagg aggttggatt cgatcatttt 405840 taagggacct tcaaatcctt agaccgtgat tcaaatggta agaagtttgc tccattaaac 405900 tcccaggcac caccctttcc ggagacaacc tttaaaaatt attagctcct gggaaaatag 405960 atgtatctca ttttctttgt atccctcaca gtgccatatg tgaagactta catatggtat 406020 atgcccccaa cattactact gagtgagtga acaaagaaat gagggaatga atggatgaac 406080 aaatggctca tggcaggctt ttccctgccc tgtgaattcg gcttctactt ggtaagaagg 406140 tgattgcaat ctctgttctc agggttcccc aaggattcct gtgtaacaga tgaaggaatc 406200 acgtctgtca ggtagagtag gtgactgcat tcagagtata catttccagt ctcccctgtc 406260 tttttctttt gatgagtatt atagagaggg aagccatgag tggattagat gccaaaatcc 406320 ctggctgaga gaataacctt accctggagg aaaacatatt agctttgact ctgagctggg 406380 aatttcggtg atgttgtaga ttcaatgcat tgcagttggg tgtttttatt tgttgaaagg 406440 aattgctgaa ttttcaaatc cattaactgc ttgtcagcat tagcaagcct aattagttaa 406500 tactaagtaa atttgcacta aatatacaac cctggctgat tttactggcc acgtctggca 406560 gagggcagca gcagggagaa agctctgtag agtttctgtt ggaatcgtgt gaaaagctgg 406620 agaggttgct tctctttctc tctctctctc tttctctctc tctctctgac acacacacac 406680 acatacacac acacacaatt gtaataataa taatattttg gttcctcact aagccaatct 406740 aaatcgcaga agtctatttt gttaagtaag cttggcccca gccatatgtt gctactcaga 406800 gaatttaata tcagatttca tctgactgta aacgtgaatc atcaggttgc acaaggaaca 406860 cagtggcaga tccagggggc atttaacttt tatagcattt taaatgaaaa aaaaaaaaag 406920 taacacttaa acaagtaatt tagatcatgc tgtaggccct gaatagcttt gatgttgtgt 406980 tttcatggca agtctccaac ttgagctgaa ttttccccta ctaaaaatgc aaatttttct 407040 aagaccttct cttggtcctg ctactcatga tacatatttc ttttaaaaga aatttcaaac 407100 tagataatag ttgttctcct ccccaccccc gccaccagta gtgtggtggg gcagcagagt 407160 tgtggctagt ggaggagagc agaggaggag agtagggaaa ggagaatgcc atttgcctac 407220 atttccctct gcccatttcc cgctgcccat ttcccccctt gttttcctga acgtgaactg 407280 agctctgggc actgttttag gcctagcagg ggacaggata aagcctgctt ctctaggaat 407340 tcgcactgag ggtgtgagtg tgtgcacgtg tgtgtttgga ggcgggagaa taaacacaaa 407400 taaataaaaa ggagaatttc aggcagtgat aagagtgctg agaaaaacag aacggtgtga 407460 aagaggaagg ctgagcctgc agaggcttga ggctgctgcc actgggtagc ggtaggcctt 407520 tccgaggagg cggcatttga agaccggagg aaggttcatc ccagcaagta ggaacagcaa 407580 gtgtaggtcc cctaagtctt gggggagctt agttccttta agggcagcac aaaaatcagt 407640 gtggctccgg agagcacatt aggggagaga ggcaggaaga gcttggagac atggatggaa 407700 gctggaccag ttgggccttg ttgaacatgg aaaggcattt agatcgtatt ctgagttaaa 407760 tgggaagtga cgtgagagat ttaacaatgg agcgtcttga actgctttac tcatttaaaa 407820 tacccactcc tgcttggctg aatatctcat gttgtctttt tagaagcttt ggcgatccta 407880 tttgaatgca tttaggtcct attggagggg aataggatct catttgaggc cacggaggtc 407940 catggaagtc acctgcatag caaataccct gaaagtggct gcagggagag tgtgagggtg 408000 ggaccgccct ggtaggaggt ggaaaatgaa aaacacacgg ccatgagttc cagattaggg 408060 cttctgaaag ccctcagctt tcccagctcc catcctaaag tgggtcttta aacaggaaga 408120 aagaaagatt gctaagtgtc tttggagttc ctcttccttc cccttctagg gatttcagca 408180 ctcctggggc tcgggttggc tctaaagtag tcctttctgt gtcttcccac ctacagtaac 408240 aaaggcatgg agcatctgta cagcatgaag tgcaagaacg tggtgcccct ctatgacctg 408300 ctgctggaga tgctggacgc ccaccgccta catgcgccca ctagccgtgg aggggcatcc 408360 gtggaggaga cggaccaaag ccacttggcc actgcgggct ctacttcatc gcattccttg 408420 caaaagtatt acatcacggg ggaggcagag ggtttccctg ccacggtctg agagctccct 408480 ggctcccaca cggttcagat aatccctgct gcattttacc ctcatcatgc accactttag 408540 ccaaattctg tctcctgcat acactccggc atgcatccaa caccaatggc tttctagatg 408600 agtggccatt catttgcttg ctcagttctt agtggcacat cttctgtctt ctgttgggaa 408660 cagccaaagg gattccaagg ctaaatcttt gtaacagctc tctttccccc ttgctatgtt 408720 actaagcgtg aggattcccg tagctcttca cagctgaact cagtctatgg gttggggctc 408780 agataactct gtgcatttaa gctacttgta gagacccagg cctggagagt agacattttg 408840 cctctgataa gcacttttta aatggctcta agaataagcc acagcaaaga atttaaagtg 408900 gctcctttaa ttggtgactt ggagaaagct aggtcaaggg tttattatag caccctcttg 408960 tattcctatg gcaatgcatc cttttatgaa agtggtacac cttaaagctt ttatatgact 409020 gtagcagagt atctggtgat tgtcaattca ttccccctat aggaatacaa ggggcacaca 409080 gggaaggcag atcccctagt tggcaagact attttaactt gatacactgc agattcagat 409140 gtgctgaaag ctctgcctct ggctttccgg tcatgggttc cagttaattc atgcctccca 409200 tggacctatg gagagcagca agttgatctt agttaagtct ccctatatga gggataagtt 409260 cctgattttt gtttttattt ttgtgttaca aaagaaagcc ctccctccct gaacttgcag 409320 taaggtcagc ttcaggacct gttccagtgg gcactgtact tggatcttcc cggcgtgtgt 409380 gtgccttaca caggggtgaa ctgttcactg tggtgatgca tgatgagggt aaatggtagt 409440 tgaaaggagc aggggccctg gtgttgcatt tagccctggg gcatggagct gaacagtact 409500 tgtgcaggat tgttgtggct actagagaac aagagggaaa gtagggcaga aactggatac 409560 agttctgagg cacagccaga cttgctcagg gtggccctgc cacaggctgc agctacctag 409620 gaacattcct tgcagacccc gcattgccct ttgggggtgc cctgggatcc ctggggtagt 409680 ccagctcttc ttcatttccc agcgtggccc tggttggaag aagcagctgt cacagctgct 409740 gtagacagct gtgttcctac aattggccca gcaccctggg gcacgggaga agggtgggga 409800 ccgttgctgt cactactcag gctgactggg gcctggtcag attacgtatg cccttggtgg 409860 tttagagata atccaaaatc agggtttggt ttggggaaga aaatcctccc ccttcctccc 409920 ccgccccgtt ccctaccgcc tccactcctg ccagctcatt tccttcaatt tcctttgacc 409980 tataggctaa aaaagaaagg ctcattccag ccacagggca gccttccctg ggcctttgct 410040 tctctagcac aattatgggt tacttccttt ttcttaacaa aaaagaatgt ttgatttcct 410100 ctgggtgacc ttattgtctg taattgaaac cctattgaga ggtgatgtct gtgttagcca 410160 atgacccagg tgagctgctc gggcttctct tggtatgtct tgtttggaaa agtggatttc 410220 attcatttct gattgtccag ttaagtgatc accaaaggac tgagaatctg ggagggcaaa 410280 aaaaaaaaaa aagtttttat gtgcacttaa atttggggac aattttatgt atctgtgtta 410340 aggatatgtt taagaacata attcttttgt tgctgtttgt ttaagaagca ccttagtttg 410400 tttaagaagc accttatata gtataatata tatttttttg aaattacatt gcttgtttat 410460 cagacaattg aatgtagtaa ttctgttctg gatttaattt gactgggtta acatgcaaaa 410520 accaaggaaa aatatttagt tttttttttt ttttttgtat acttttcaag ctaccttgtc 410580 atgtatacag tcatttatgc ctaaagcctg gtgattattc atttaaatga agatcacatt 410640 tcatatcaac ttttgtatcc acagtagaca aaatagcact aatccagatg cctattgttg 410700 gatactgaat gacagacaat cttatgtagc aaagattatg cctgaaaagg aaaattattc 410760 agggcagcta attttgcttt taccaaaata tcagtagtaa tatttttgga cagtagctaa 410820 tgggtcagtg ggttcttttt aatgtttata cttagatttt cttttaaaaa aattaaaata 410880 aaacaaaaaa aaatttctag gactagacga tgtaatacca gctaaagcca aacaattata 410940 cagtggaagg ttttacatta ttcatccaat gtgtttctat tcatgttaag atactactac 411000 atttgaagtg ggcagagaac atcagatgat tgaaatgttc gcccaggggt ctccagcaac 411060 tttggaaatc tctttgtatt tttacttgaa gtgccactaa tggacagcag atattttctg 411120 gctgatgttg gtattgggtg taggaacatg atttaaaaaa aaactcttgc ctctgctttc 411180 ccccactctg aggcaagtta aaatgtaaaa gatgtgattt atctgggggg ctcaggtatg 411240 gtggggaagt ggattcagga atctggggaa tggcaaatat attaagaaga gtattgaaag 411300 tatttggagg aaaatggtta attctgggtg tgcaccaggg ttcagtagag tccacttctg 411360 ccctggagac cacaaatcaa ctagctccat ttacagccat ttctaaaatg gcagcttcag 411420 ttctagagaa gaaagaacaa catcagcagt aaagtccatg gaatagctag tggtctgtgt 411480 ttcttttcgc cattgcctag cttgccgtaa tgattctata atgccatcat gcagcaatta 411540 tgagaggcta ggtcatccaa agagaagacc ctatcaatgt aggttgcaaa atctaacccc 411600 taaggaagtg cagtctttga tttgatttcc ctagtaacct tgcagatatg tttaaccaag 411660 ccatagccca tgccttttga gggctgaaca aataagggac ttactgataa tttacttttg 411720 atcacattaa ggtgttctca ccttgaaatc ttatacactg aaatggccat tgatttaggc 411780 cactggctta gagtactcct tcccctgcat gacactgatt acaaatactt tcctattcat 411840 actttccaat tatgagatgg actgtgggta ctgggagtga tcactaacac catagtaatg 411900 tctaatattc acaggcagat ctgcttgggg aagctagtta tgtgaaaggc aaatagagtc 411960 atacagtagc tcaaaaggca accataattc tctttggtgc aggtcttggg agcgtgatct 412020 agattacact gcaccattcc caagttaatc ccctgaaaac ttactctcaa ctggagcaaa 412080 tgaactttgg tcccaaatat ccatcttttc agtagcgtta attatgctct gtttccaact 412140 gcatttcctt tccaattgaa ttaaagtgtg gcctcgtttt tagtcattta aaattgtttt 412200 ctaagtaatt gctgcctcta ttatggcact tcaattttgc actgtctttt gagattcaag 412260 aaaaatttct attctttttt ttgcatccaa ttgtgcctga acttttaaaa tatgtaaatg 412320 ctgccatgtt ccaaacccat cgtcagtgtg tgtgtttaga gctgtgcacc ctagaaacaa 412380 catattgtcc catgagcagg tgcctgagac acagacccct ttgcattcac agagaggtca 412440 ttggttatag agacttgaat taataagtga cattatgcca gtttctgttc tctcacaggt 412500 gataaacaat gctttttgtg cactacatac tcttcagtgt agagctcttg ttttatggga 412560 aaaggctcaa atgccaaatt gtgtttgatg gattaatatg cccttttgcc gatgcatact 412620 attactgatg tgactcggtt ttgtcgcagc tttgctttgt ttaatgaaac acacttgtaa 412680 acctcttttg cactttgaaa aagaatccag cgggatgctc gagcacctgt aaacaatttt 412740 ctcaacctat ttgatgttca aataaagaat taaactaaa 412779 <210> 42 <211> 595 <212> PRT <213> Homo sapiens <400> 42 Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 1 5 10 15 Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 20 25 30 Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 35 40 45 Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 50 55 60 Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 65 70 75 80 Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 85 90 95 Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 100 105 110 Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 115 120 125 Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 130 135 140 Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 145 150 155 160 Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 165 170 175 Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 180 185 190 Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 195 200 205 Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 210 215 220 Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 225 230 235 240 Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 245 250 255 Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 260 265 270 Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 275 280 285 Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 290 295 300 Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 305 310 315 320 Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 325 330 335 Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 340 345 350 Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 355 360 365 Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 370 375 380 Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 385 390 395 400 Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 405 410 415 Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 420 425 430 Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 435 440 445 Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 450 455 460 Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 465 470 475 480 Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 485 490 495 Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 500 505 510 His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 515 520 525 Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 530 535 540 Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 545 550 555 560 Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 565 570 575 His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 580 585 590 Ala Thr Val 595 <210> 43 <211> 20065 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..20065 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 43 ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag 60 gctccgcacc agccgcgctt ctgtccgcct gcaggtaggg agcgttgttc ctccgcgggt 120 gcccacggcc cagtatctct ggctagctcg ctgggcactt taggacggag ggtctctaca 180 ccctttcttt gggatggaga gaggagaagg gaaagggaac gcgatggtct agggggcagt 240 agagccaatt acctgttggg gttaataaga acaggcaatg catctggcct tcctccaggc 300 gcgattcagt tttgctctaa aaataattta tacctctaaa aataaataag ataggtagta 360 taggataggt agtcattctt atgcgactgt gtgttcagaa tatagctctg atgctaggct 420 ggaggtctgg acacgggtcc aagtccaccg ccagctgctt gctagtaaca tgacttgtgt 480 aagttatccc agctgcagca tctaagtaag tctcttcctg cgctaagcag gtccaggatc 540 cctgaacgga atttatttgc tctgtccatt ctgagaaccc aaaggagtcc taaaagagga 600 atggaggagc ctaagaataa aaatagtata ataaaacatt tcttagacac attgaccttg 660 gcctatgtca aagttcagtc tgggtttgtc ttataacaca aggagtaaaa gtaccattgt 720 tctacctctt tttttaatac ttgaaaaaaa tttactgtgg atgcttttct atgaattaaa 780 taaccttcta aaaaatgttt tcattgctgc attcgattag attgggtaac taaatgaaat 840 taattcctca ctgttgggta taaaggttat ttacagtggt tctgtcttag ccattcactg 900 aactcattgc atatatatct ctggaatatt gctgattgtt tccttcaagt aaacttagaa 960 gtgtaactac ttagtcaaag agcctgaata ttttaaaggc cttttgaaga aaactgaaaa 1020 tgctttccag aaaggatgta tcagttgaca atgacagtcg tcaacagtat ttaaggagaa 1080 ctatgatact ctgaagaaaa acttagcctt tctcagtaaa agtaggtagg cagaggccac 1140 atgacagcag ttagagtgtg gtcttcaagg aagtcacaga aatactgtgg ggaattgaaa 1200 ccccatgtgg aaaatgtaca agagtgtctc agtgtgactg agaaggaggt tgggcatggg 1260 gtttcatgga gtttaataaa gtttggtcac ttagtagagg tttaataaat caactgtctt 1320 aatctttgat cctacttaag aatttttttt ttgtttttgt agagatgggg ctcttgttat 1380 gttgcccagg ctgttctcga actcctagcc tcaggcgatc ctccctcctc aggctccaga 1440 agtcctggga ttactggcgg gagccaccat gcaggcctct tgctcctact tttgagaaag 1500 gaagtttaac cggttttttt tgtctttttt tttttttttt tgagacagag tctcactctg 1560 ttgcccatgc tggagtgcag tggtgcaatc tcagctcact gcctcccggg ttcaagtgat 1620 tctcctgcct cagcctcccg agtagctggg actacaggca cctgccacca cgcccagcta 1680 atttttgtat ttttagtaga aatggggttt caccatattg gccaggctga tctcgaactc 1740 ctgacctcag gtgatccgcc tgcctcggcc tcccaaagtg ctgggattac aggcatgagc 1800 cactgctcct ggctgcttaa ctttttctct atctcatcct cctacccatc ctacccttgg 1860 aagatagaga agtagtatta gttccatagt gttatactgg gcttccccca gggacaaacc 1920 cacttcccca acctgaatga gccatcactt cttccccagt ttacatttca ttgctcttta 1980 aatgtctcca ttcggatatg ggaattcaca tatggtcata attcttacct gaagaagatg 2040 tcagtcttct tctcttagac caactgccct gatatgaggt ttagaggtta aagaacatgt 2100 gtgtatttac atgatctttg tattctgcct tttcgtccct cactaatgac agctgcaccc 2160 caaggaaatg gagctgtgga agagagggtt tgataagaaa ttaagtaaat attggatcta 2220 atccatcacc ctccaggaag cctttattac tcctaaaaat ttcaaccaaa ttcattaaag 2280 gacaagaact ccaccagagt aggccataaa cattggcaaa attagttgta atccatgact 2340 agatttaatg tccctttgtt ttattcccat atggttataa tgctttgctt ggcattaggg 2400 gtattttaag ttttcttctg cctagtaagt gaatttgtgt ttataataca ataatcataa 2460 aatatcacat taatatttta taactgtaca gttataaaat attttataag taatatttat 2520 attttataag taatatttta taactgtaca gttaactctg gcccaaggaa aagatagtct 2580 gatagatgct gcagccccat tttagcaaat gtgacctcac aggcctgaat gccatcgcta 2640 ttccacatct acaggataga cggaaaggaa agaaataaaa aaataggtac ctaacactgg 2700 caagaggatg atgactcatg ttatttcact taaccttttt atcttttaac atgaaggact 2760 catacaggtt gataagaaac cagtgacata aacagaccaa aaaatgatca gatctttcaa 2820 attagcaaaa aaataatatt ttttaaacaa tgggtgaaaa tacagtgtaa cagtaccaat 2880 tatcaacatg tgttgagaac cagaaaaatg ttctttttct ttgatcagca acactatttg 2940 ggaaaatcta tcctcagggc ctagcctggg gccctggcac acagtaggca ctcaacgaat 3000 atttgctgaa cacacaaata cttatgatat tttaaaaaat tggcaacaat ctgataccta 3060 acaatagagg gattaaatat tatggaactg ttaaataaga tgcttatgaa taccatgcag 3120 taagatgggc aatatttatg ccataagctt taatgaaaca aatgggtatt aaatgtatga 3180 taaggttata aattactttt taaaagatta cagggaaaaa aattgaaaga tatacactga 3240 aatgtttttt gctcacagtg gtgacaaggt ttctcagcac tggcactgtt gacgttttag 3300 gctgtatgtc tttgctgtgg gaggctggcc tgtgcactgc agggtgtttg gcagcactct 3360 tggcctctgc ccctagatag caatagcagt cctccctcaa ccagcccaat tttgacaacc 3420 aaaaatgttt ccaggcatca ccagatgctc cctgggtgag agtgatgaaa tagtagggga 3480 ttttcccctt cttttcttat tttctgtaat tccattatat tactttaata ataaagaaaa 3540 aaacataaaa aataaacgaa tgttattatt ctacgtcagt ttggatgttt ggactccatt 3600 ttggggttct ttccattata tcacttggtc tgctaaacat tctacggttt ggtaaggtga 3660 agtgattcat gaaattttgg ttttattttt ttcctgatac taaaaataaa acattctttc 3720 acttggaaat ttggacacag aacaccaaaa aaaatccata atctcatctc tctttttctg 3780 tcttttcctt ccttttttcc ctttaaaaac aataaagagt gaaacctacc tgttctccct 3840 ctaatttaat tcctaaatat aatcactgtc aatatcttgg acatttcctg tgtctaaaca 3900 cacacacaca cttttttttt tcagcaaaag tggatttctg ctacatgtag tgttctgcaa 3960 cttactttct atgtgtttac aaaatcagta catgtacata tgctgaattc agtccttaat 4020 ggtattatat tttgtgaata taccaaaatt tgtttaacca cttagacaat ctaggatatt 4080 ctcagtttgc tgttatgagc aatgctcttc ctttacatat acagacatat atatatatat 4140 gtgtgtgtgt gtgtttttgt tttagtagga tagatttcta ggagagggtg aaaggtctta 4200 tgacatccgc atttacgatt gtaataggaa gtatcaaagt gccccctaaa gaaaaaaatc 4260 ctcccattag tgggtaagaa agcctatttg ttcatatctt cacaaacact aaatattaga 4320 aatatttaca attgtggtca agctcataag tgaaaatggt atttcatatc ttatattttt 4380 tattgtgaga ttgaacatct ttcatatgtt tacatgtcac ctgtatttct tattctctga 4440 actatatgtt atgacctttc actttttttc ctcatgggtt atgtgtagtt tgtatagttg 4500 tcttattgat tgttaggagc tatttatata ttaggaacat taatctcctg tcttatatat 4560 acgtggcatc gattagttga tcatttgtga gttcatgtct gtatacaaag attggagagg 4620 cactaagagg gaaaacttac ctctttctta tcaaagtttg taaatatatg tataacagaa 4680 gagggagaaa atattaataa atgcacagat tggctgaaat agagtataaa tcttttactc 4740 ccctacttca acataaactg caaaaggaga gtgacttttc tttcactctg acttccgtat 4800 tcctcatgct taaaatagtg cctagcacag aagaggtgct caatcagtgt ttgctaaacg 4860 aaataattag tcacatttca agcaggatga ctaaatgaag aatagaatct aggcagatac 4920 tctggaagag tggctgtgag tcattcatat cttagtatga attagtcaaa tccaactctc 4980 tccccttccc actccccact gttagtagaa gaatctgttt attgagagaa tagatttata 5040 atttagaata agtgagaggg gcagaagagg agattttgaa ggatggcacc tgaaggagga 5100 ctagcatggc tgagacagtg aagtggaagc cttgaatagc taaagggtaa gatgaaagta 5160 tttagctgta gggggaaaaa gcattgacag gttggaaaag taaaagtcag attctccttg 5220 ctctgaaatt ttgtacaggg caggttctac taggtatgtt acaatgcaga aaaaacatga 5280 aataattgag aggaatttgg tgcaatatta tcttcttggc ttcttttgag tgggcagatt 5340 tttttcacgg cctgtaacta taataaattt gaaacttctc atcttttagt aacttttttc 5400 acttaagttt atgtggctgt gggcaatgga atgaagatat tgaacttcca attccctgtt 5460 gggtttccac aattacaagt caatcatgac tggttattag aagactattt cagttagaac 5520 caccaagtcc catattgtca tattgtatgt ttaattatta agtgaagcag tcttcttttc 5580 gtgttttcca taattagggc attccagaaa gatgaggata tttgctgtct ttatattcat 5640 gacctactgg catttgctga acggtaagac accaaatcct tccattaggt tctatatttt 5700 aaatatttta accatgagtt taaaactaaa atgatcattt aaaatgcatg caattttctt 5760 atagagagaa cattctattc tttcttctac tttacacaat ggcaaagtct tctttctact 5820 ttacgcaatg ataaagttac ctgtgtcatt ttgtaaaaat atagagaata tagacaaatt 5880 gaaagacaca aaataatcta ttacccattt cccagggtta actactgaaa atatctgggg 5940 aaatggcctg tatgtataca tttatttgtt tgctttcaac aaggccaaga tcctttgatc 6000 tttcagtctt ggttgctctg tgacatgcct ttcctgatga ggatacttta aggaagaatt 6060 gtaagataca tggaaaatgt caggctaaca cagtactggc atcaccctgt gctctttcct 6120 gaactccata ccaatgtact tcttgccaga aaactgatca aaagtttagg gaagtaaaaa 6180 gagatgactg ttagaatcta ccattccctc tatgtaggaa gcaaataggt gtcctgtcaa 6240 aggacattct ggggatgtct acatgaaacc aactctccct ggttgtaagg actccatctc 6300 catataatat ttatacagta atatatgttt ataaattgtg ggggcaactt gtttagctaa 6360 ttttattatt ctgctattgg gacactgtgt ctcagcatga gatatagtgt cccaaaacat 6420 atttcaagcc cattggataa aatatgtgtt tagcaagttc ttaaatataa tgataacata 6480 accgaccaga taaagtgatt tataaacgct gtgccaattt tgtaaatgtt tcgaggaatt 6540 ttcccttttc tgaagattgt ccttctttct ttttagcatt tactgtcacg gttcccaagg 6600 acctatatgt ggtagagtat ggtagcaata tgacaattga atgcaaattc ccagtagaaa 6660 aacaattaga cctggctgca ctaattgtct attgggaaat ggaggataag aacattattc 6720 aatttgtgca tggagaggaa gacctgaagg ttcagcatag tagctacaga cagagggccc 6780 ggctgttgaa ggaccagctc tccctgggaa atgctgcact tcagatcaca gatgtgaaat 6840 tgcaggatgc aggggtgtac cgctgcatga tcagctatgg tggtgccgac tacaagcgaa 6900 ttactgtgaa agtcaatggt aagaattatt atagatgaga ggcctgatct ttattgaaaa 6960 catattccaa gtgttgaaga cttttcattc ttgtaagtcc atacttattt tcaaacagaa 7020 cagcatagtc tgttcattca ttcattcaat tcatgaattc attcacataa ttatccaatt 7080 tcttgagcac ctatttgata gtcactggaa atccagagac aaacaacaca gagccatgtt 7140 ctacagtatg tacagttttc caaaaagaat ttctagtctt tactttttta ttacaaatgg 7200 aatacgtata cttgcaaata attcagatac tgtggaagag atcaaatgaa ttgcaaaagt 7260 gtccctcctc ccttcaccac tatctcccat ggcatgcaga gagagtaacc attatttgtg 7320 tgtccctcca gaaatttttt tattcaacta ctattttttt attttattag gtccgtcagt 7380 tttccttttt tgagcctctc tatatcaaat gcaaataaat atattcagaa caaaccccac 7440 tgtaaggttc acattaaaaa agacttgaag tcaccctatg aagacaaaaa ataatcacat 7500 taagtgtgaa agaacctatt cttccagtac aggataagcc atacttactg ggcatatatt 7560 catcttgaaa atctatactg atgttgtctt ggggaattga aaaggaacta ggagtgttag 7620 ttcctcggta ttgacccaca gttatgttat caggtcactt gagttcaaag ttttgtgttg 7680 gcactagcta agtaaaggaa aacacctctg ctttcattgt tgagtttcac agaattgaga 7740 gctgaaagga tcccaggcag gagcagctaa tccaaactcc cacaaagaac aaaaatcccc 7800 cagaggatct tctgttctta tatttcctgc aatggcgtcc ctgtcatatc ccacaatggc 7860 ctccctgcca tttggatatc ccttccatat cctgttgaaa ttactcccta atagtaagct 7920 gaaatctgcc cctctagttg tagtcttggg attatttcat ttacatgatg accttttaat 7980 atttgactag aattaaatca tctccccttg gtctttccat tcctgggcta actaccatca 8040 atctgagggc taacaataca agtagaaaaa gtatacattt gtcactgatc actgatcaat 8100 tattaatcaa tgatcactga taactataaa ctcaaaaaca aaatcatgtg gggattaaga 8160 gaaatgtatc agttttatgt tgtatttctg gtccctgata ctggctcagg taatgccact 8220 attgtcaaga agataccact tgtaaagtag atttaatttt cattatattt taccatatgc 8280 ttctccattc atgacatctc ttgagatgtt gtggtttata ctttcagttt ttctccagtc 8340 catccgcaaa tatcaggcat ctactgtgtt ccaagatatt aaagaaatca tcatgactta 8400 gcctcatcaa cagcattgct agatctggga tggaaaggaa gagtataatc ctggcagtca 8460 ggaagaaggc agcataaagt ataagtttct gcttccaaaa aaggtctctc atcagcctgt 8520 agggagtgtg tagggaaggg acagctgtcc ttgtagtagg gaagggtttt attcaggtcg 8580 tctgggctcc ataatatccc ttgtgtatct gcagtctcct ttgccatgga tcaacacaat 8640 aggaaatctt ccggcactga tggtttttcc aagggggagt tcttcctgga gcaaagcaaa 8700 tgaccaacca ggtttgagga cctgatttgt ttgacaattc cattttgtat tgtaaattac 8760 ttaattggca ttctactccc aatccatctt gtcatttgca tacagtggtt ttgggattga 8820 gttcagctat accaaaagtc tgaaccttct gcacttagaa caaggcaacc accaagcttc 8880 acttgcactg aggccgtgtc tccaatggaa atgaggcagc tggcttgcag gagcttccca 8940 actcagggaa gtagaactcc tgagtcacct ccatatgcaa atgatttcac agtaatgctg 9000 ttgaacttca cttcccatca cagcaaatgt gtggtaacat agcttcccca caggagttta 9060 ctcaccatgg tattttaaag gtgaaacatt tcaaaactga aatttgaaag aatttagttt 9120 tggattcact caattatcac tatcacttcg ggtgttattg cacctttctt gtttgtgagt 9180 ttaaatgcca gactctcagg ccactaactt tcaattaaaa gtgtttttct ttaatcgctg 9240 aacctaacag cagggaaaac gaaatgttca ttcagacttt cagaaccttc aatgagatta 9300 ggcagctgaa agatcaaagt gttgcatagt tgtcccgata aagctatttg gatcatatgg 9360 accaaatcga ctgctgtcat tccccaccaa ccccatctct ccccaaaatt cccagccctg 9420 tttaagtgtt ctctgtagca tttatctcta tctagtatat tgtgtagcat atcatatcat 9480 acttttctgt tttgtttatt gtctctctcc tcctagaata taaactccac aagcacaaag 9540 atttgggcct gttttataat attgttgcat ccccagggcc tgatatacag cagagtggtg 9600 gtacgaaaag agcacacaaa aaaatatttg ttgagtcaat gaatgaatga tttcctcaaa 9660 taggattagc ctaaaatttt ggaaacatga acagatttgg atatgtgaaa atttatttcc 9720 agactgttca tcaggaactg ttagcagctt ctaaagggta cactggagca gcagtagtaa 9780 aaggaggaag aggagcagct ctgctactgc tactatcgag tactactaca attagcactt 9840 gcttattctg tgtgttaggc cctgtactga acactctgtc taaattagtt catttcctcc 9900 tggaaatgac tctagggggt aagtgcttca tcatgtaaga tgagtatttt tcacattttg 9960 ttgtgtctga aatctgagtg tgtctttcaa tgatggaatc tttgattcca tgataagtgg 10020 tattattccc attttaagga tgaggaaact gaggtccaaa gaaattaagt aatttgccca 10080 aattcaccca gcctagaaaa tgataaagct agttctaaac ccaagcagat tagctctgaa 10140 gtctgggccc ttaataacca ctttttattg cctatatttg tacctctggt gtacgtatca 10200 agttatatgt tgacttcaaa actatcatga ccttttcttg gttttgattg tccaacatta 10260 gtatagtgtt ctgggtctgc aaaaattttg attactcatc tcatctgtaa aacattttga 10320 actcgtgtgt ttgtgcatgc acatttgtgt gtaattataa aaattttact ttctgttaat 10380 atataagttg tatcataaga aactgccgtt tttgaagagc aaaaaaaggt tgaatgttac 10440 cagttacatc tggttcaacc taatagacat ttgtacaaaa acagacattt taagaggttg 10500 aaataaaaat ttaataaaca atattttcag tttttactaa ttgtgatgct tcactatcat 10560 tagctaatat gtcaaggcat aatatacctt agggtgaact ttatcattaa caaaggtgga 10620 tggtgtcaat aatcttgagg tttgtgtttt tttatataac actgcgaggt ctaattaagt 10680 acttactgtt taccacctca tacagtggcc gataaaaagt gtcacttctg ctgtttcctc 10740 tgggttgtgc ttgaattatt agtattatct tcagtcctca gtttctttgt gggaaacttt 10800 ttaattagtt gtttaatttt gtaagatggt tagtttagtc aaaattagat aagagaattt 10860 gaaaatccgt agctacccca aagcaaccta cacataagaa ctattatttt tgtgttttga 10920 aatcataatt ttattgattt ccagtgtttc cactggtagt ggtttcattg atataggagt 10980 atcaaaacat cactcattat ttatttcagt ttcatttgat cctagccgtt ttgtattaac 11040 tctctgtgaa gaaattacct cacaaatcta ttgctgtcct tggtaaagga atggagaatt 11100 aaggctctag atcattagtg gttacactat agtattagaa gtaaaaaaaa gattatacca 11160 acaaaataag aacatgttaa tgtacttgta atgaataaac atgaataaag ctcttatgct 11220 atataggtgc actaaacaat ctactagaat tgtcagcaaa ctacgtatct taatcctgaa 11280 agggtcccaa accaatgatc taaaattgaa tcaaactttc ttccttgagc ataattactt 11340 aaatgattta ttaaaatagc cagcatttaa aagcttaaaa tgtaaatatc ataatgtggt 11400 atcctagata gcatcccaga acagaaaaag gatattaggg aaaaactgga ggaatggaat 11460 aaattatgca gtttagttat taataatgta ctaacgtcct tagttatgac gattgtacca 11520 tggtaatgta agatactaac aatagaggaa accgggtaag gagtatacag taactctata 11580 ctatctttgc aacttttttg taaatttaaa acttctaaaa taaagaacaa atttaaacat 11640 taaaaagtat caccaggaac atatatcact gtttacagat gaaatactat gtattttcat 11700 atctaatttc tgatcattga cttcaaatca gaaaagtgaa tgacacctca aaatcaggtt 11760 ttctgtttac tgaagtctaa gaaaagaaag cataccagct ggagagattc atgtttataa 11820 agacagattt ataacaacaa aaataaaata tccaagaata aatttaagaa gaagcacttt 11880 actgagaaac atatgaaaac ctgaacaaat ggagagggat attttgtatt tgaatagaaa 11940 gacttctggt ttaaagataa ttctctttaa attatttttt gtagaaattt aaggggtaca 12000 agagcagtgt tgtcacatgg atatattaca tagtggtgaa gtctggggtt ttagtgtaaa 12060 ttaatcttta cattttgttt gagcccaata aatgtaccaa catgattttt atagaaagat 12120 agtcattcct attaatccaa acttgtccca actttgaatt gaattgaggc agagctagca 12180 ggtgttcccc acggctgagg catctgaaca ttaagcatat ccctctgaga accagcctgc 12240 attgatactc tttctaatgt ggacagcatc aagctatgta cgtagttctg tgctcagcaa 12300 aagccctgac ttctttttgt ttatgtccta gccccataca acaaaatcaa ccaaagaatt 12360 ttggttgtgg atccagtcac ctctgaacat gaactgacat gtcaggctga gggctacccc 12420 aaggccgaag tcatctggac aagcagtgac catcaagtcc tgagtggtaa gaccaccacc 12480 accaattcca agagagagga gaagcttttc aatgtgacca gcacactgag aatcaacaca 12540 acaactaatg agattttcta ctgcactttt aggagattag atcctgagga aaaccataca 12600 gctgaattgg tcatcccagg taatattctg aatgtgtcca ttaaaatatg tctaacactg 12660 tcccctagca cctagcatga tgtctgccta tcatagtcat tcagtgattg ttgaataaat 12720 gaatgaatga ataacactat gtttacaaaa tatatcctaa ttcctcacct ccattcatcc 12780 aaaccatatt gttacttaat aaacattcag cagatattta tggaatatac cttttgttcc 12840 atgcattgta gtactcattg gatacacata gaataataag actcagttca cactcttcag 12900 gaaacagata aaaaactaag aaacaaacaa aaaacaggca atccaacacc atgtgggaaa 12960 tgctttcata gccgggaaac ctggggaata cctgagagga atactcaatt caggccttgt 13020 ttcaggaatc caaatcctgg cacatcagag ctgcttccct ctttccaggg tggcaggaaa 13080 taaatggaac atatttttct atcttatgcc aaacatgagg gaccctttct ccccggtgcc 13140 tctcccaagg tagtctacaa tatttcaact ctagcagtct gcttagtgca tagaacatga 13200 ggctgtgtgt ccctgggcaa attactagac ttctgtgtgc ttcactttcc ctgtaggatt 13260 ataatctact gagcaagctt attgtaaggg tcagattagc aacagtgtat gaaaatgatt 13320 tgagaccatt gcctgcacaa attcaactat ttttttttat ctcactactc tacagaagta 13380 ggtagggtgg gagacagagt ctgatgagag gctcagaatg tgaaagaaag tgaggcgagt 13440 gagcatgata tttaatataa acacaaagat attctgagaa gagctgctca ctgccccctc 13500 ccccaataca tgttgatagg aaaatgccac gtacttcagc aaaaacaact gaaaaattag 13560 atagaaaagt caatcaatag gaaaagataa tccaggacgg tgttgtgaac agaaagaggg 13620 ggaaaaaact ttagaaaatg atggggatgc tcttactggg gtacgagtcc tcaggtattg 13680 aactggcttt cagtaaaagc tagattagtg ggttcctgcc atttacaagc tgttttatga 13740 caacttactt gttgggtggc ctacagtaac tcacctaact gcactgagtc tgtttcctca 13800 tctgtaaatt ggggattttt ttttaaatac ctggcatgcc taactcataa agttgttctg 13860 aaactgaaat aaaacatacg tgaacaggca ttgtaaactg taagttacgg aaaaagctgg 13920 ctgttgttgt gtctttaaag tttcacctgg gtagtcaaag atggatcatg ggtctcagtg 13980 gagagctgag ccaggcagga gctgactaag ggtgagaggt gggagttagc agcctctgaa 14040 catctgtgta ccatgggacc ccctttcctc ctgcatggta ccccagacaa ggagcctagt 14100 aagagatact aatggcttgt tgtccagaga tgttcaaact gcagagaaag ataagacaac 14160 aagcattggc ctccaatcat gatgacagat aggaggaggt gggagctcct tagcagtgct 14220 ggttggcctt ccatgttcta ctgtgggcca tctctgccat gtactgtagg ctactagctt 14280 ctatattaaa gaatgcaaga ggggccagga gcggaggctc atgcctgtaa tctcagcact 14340 ttgggaggcc aaggtgggca gatcacttga ggtcaggagt ttgtgaccag cctggccaac 14400 atggtgaaac tctgccttta ctaaaaatat aaaaattagc tgggtgtggt ggtgtgcacc 14460 tgtaatccca gctactcggg agactgaggc acaagaattg cttgaacctg ggaggcggaa 14520 gttgcagtga gcccagattg cgccactgca ctccaccctg ggcaacagag aaagactctg 14580 cctcaaaaaa aaaaaaaaaa agcaagagga agtgaaataa tcaaggccgc catttaatag 14640 tgagcagcca ctccatgtgg tactgtgcaa gcacattata aatattagcc tcacaagaaa 14700 tgtattagca tttgtatttt gtacactggt taagtatctt gcccaagacc tcaaaactgg 14760 ttaagggcag cagaatttag ccccagcacc accttttcaa agcctgggct tctcacactt 14820 ctccatgctg ttcccatttt aacacaggta tctcgccatt ccagccactc aaactttggc 14880 atttaagaaa attatcctaa agctaaacta aacttcaagg atgaccattc tcctgacccc 14940 ttcccatcaa aattttatct ttagtcagtt tgttttcgtt ttgttttgtt tttcagaact 15000 acctctggca catcctccaa atgaaaggac tcacttggta attctgggag ccatcttatt 15060 atgccttggt gtagcactga cattcatctt ccgtttaaga aaaggtagta tttccttaat 15120 tgcagtggtc tccactgggg gtgaggaagg ggtgagaatt ggatcatggc tgcaaggaaa 15180 cccgacttaa cctctgcaag gtggtgcaaa ggcattccac tgttcaacag caattatatt 15240 gaagctgagt gggatcactg ggtgaagatg aagcgtaagg ggtgaggggc aggagaatgg 15300 gtatggatgg aggtagaaga tgcagtgtca tacagttttt ttctatcatg aaaataacca 15360 cagacttaca gaagagaaag agctaaaatg cccgtcattt tcagttgcat tttagtcttg 15420 cattagttgc aaccagctgg tttctgggta ccctaagtaa taaaaatagt tcctctgtag 15480 aactgtagta tgtttaccat agagtatttt gcaaaatttt tggtagagga tgttacataa 15540 tttgcatgtg ttcatttctc catttacctg tgggaacaat taaaatccag gaaaatgagt 15600 atattcaaat aatttcctcc catttaagat gagtcagagt aaataattcc tccaatactt 15660 agagaagtat accaagagat ccagtgatgg tatagagttg tctgatgtta aatagggaag 15720 tagaatatgg aaggggattc caatagtcgt tgaaaaattc cccataaccc cttacatggg 15780 ggaaagtagt gttaactgag agagtagaga taagctgttt ccaaaaatta tattcttaac 15840 aggactgaga tagccagaat ataaggatca agtttcaatg acagtaagat cctgagatgg 15900 agttgatttg cacaaagaaa taattgttgc cagcatgcat tttgaatatt tctctggaaa 15960 aaaagattag ttggcagtag aaatggatag aaatcaatag atattaaaat acctcagaat 16020 ttggttcatc tctgggaaaa gatgaaaaat aaaagtgtat actcctcaag aacatctagg 16080 atcaaaagca tgtgccctac actattgaat taattaacct cataagttgg gacctgtgga 16140 ataaggatgt ccaccagact tcctagggat tacaaatgtt tcacagaact tgaaatttaa 16200 acttgggtca ctgtatggga tgtagagctg tgctatatgg aaataaaaat gatttctttt 16260 tctcaaggga gaatgatgga tgtgaaaaaa tgtggcatcc aagatacaaa ctcaaagaag 16320 caaagtggta agaatatcag aaggaattgg gaagtaaaag tcaaaggaaa caaaaagcta 16380 aagcaataac aaagagaaat ccatcagtca taatctcctc tccttttaaa gaatgctggt 16440 tcccctttgc ctcacagcta acacaagaac tcctccaccg tctgaggagg tttaggagca 16500 gggaagggga aggagtcagc ttcatttgct aatcttctgt tgccctgcac cctagcagct 16560 ccttgcagca ggggacaagg atgacttagg tggatggata attaattgat tctaaaatat 16620 tgtgtgtcag tattgtaata ctatgttaat tgcaccatgc acggtatctc atttaatccc 16680 ccaccccttg ccattaccaa agagagagag agagagagag agagaaatac tagaatttat 16740 cctcatttta cagtagagaa aacagagggt caagaagata atgtaaagtg cccaagaaca 16800 cacagctgat cacaaaaatc aagcttgggg gccattagcc taaccacaga cccttactct 16860 taacccatct gcttcaatcc attttgctac aaatgtttac atttataagc agggcagaaa 16920 aacctcatcc aggttattga actaagaaga aagttatatt aaggtttcta atttttttaa 16980 tgtagttaga aaccaaactt aacaatgagc ccaagtttaa agcagtctaa ttaacctgga 17040 caagctcagg caagtttcat tctgtggccc atagcatcat ctgtgttgta aagctaagta 17100 gcaaatgttg tttgggtcat gctgggggac aagccatccc aatttgctca ggactgaggg 17160 gttttccagg atatcatgta aggataattg ggtacaaata taacctgctg ctttctctca 17220 tttcaaattt atcatttatc atatcagcaa ctatgagtta tgttttttat tagatttctt 17280 gttacttttt ccccagacca cttcccatga aattaatata ctattatcac tctccagata 17340 cacatttgga ggagacgtaa tccagcattg gaacttctga tcttcaagca gggattctca 17400 acctgtggtt taggggttca tcggggctga gcgtgacaag aggaaggaat gggcccgtgg 17460 gatgcaggca atgtgggact taaaaggccc aagcactgaa aatggaacct ggcgaaagca 17520 gaggaggaga atgaagaaag atggagtcaa acagggagcc tggagggaga ccttgatact 17580 ttcaaatgcc tgaggggctc atcgacgcct gtgacaggga gaaaggatac ttctgaacaa 17640 ggagcctcca agcaaatcat ccattgctca tcctaggaag acgggttgag aatccctaat 17700 ttgagggtca gttcctgcag aagtgccctt tgcctccact caatgcctca atttgttttc 17760 tgcatgactg agagtctcag tgttggaacg ggacagtatt tatgtatgag tttttcctat 17820 ttattttgag tctgtgaggt cttcttgtca tgtgagtgtg gttgtgaatg atttcttttg 17880 aagatatatt gtagtagatg ttacaatttt gtcgccaaac taaacttgct gcttaatgat 17940 ttgctcacat ctagtaaaac atggagtatt tgtaaggtgc ttggtctcct ctataactac 18000 aagtatacat tggaagcata aagatcaaac cgttggttgc ataggatgtc acctttattt 18060 aacccattaa tactctggtt gacctaatct tattctcaga cctcaagtgt ctgtgcagta 18120 tctgttccat ttaaatatca gctttacaat tatgtggtag cctacacaca taatctcatt 18180 tcatcgctgt aaccaccctg ttgtgataac cactattatt ttacccatcg tacagctgag 18240 gaagcaaaca gattaagtaa cttgcccaaa ccagtaaata gcagacctca gactgccacc 18300 cactgtcctt ttataataca atttacagct atattttact ttaagcaatt cttttattca 18360 aaaaccattt attaagtgcc cttgcaatat caatcgctgt gccaggcatt gaatctacag 18420 atgtgagcaa gacaaagtac ctgtcctcaa ggagctcata gtataatgag gagattaaca 18480 agaaaatgta ttattacaat ttagtccagt gtcatagcat aaggatgatg cgaggggaaa 18540 acccgagcag tgttgccaag aggaggaaat aggccaatgt ggtctgggac ggttggatat 18600 acttaaacat cttaataatc agagtaattt tcatttacaa agagaggtcg gtacttaaaa 18660 taaccctgaa aaataacact ggaattcctt ttctagcatt atatttattc ctgatttgcc 18720 tttgccatat aatctaatgc ttgtttatat agtgtctggt attgtttaac agttctgtct 18780 tttctattta aatgccacta aattttaaat tcataccttt ccatgattca aaattcaaaa 18840 gatcccatgg gagatggttg gaaaatctcc acttcatcct ccaagccatt caagtttcct 18900 ttccagaagc aactgctact gcctttcatt catatgttct tctaaagata gtctacattt 18960 ggaaatgtat gttaaaagca cgtattttta aaattttttt cctaaatagt aacacattgt 19020 atgtctgctg tgtactttgc tatttttatt tattttagtg tttcttatat agcagatgga 19080 atgaatttga agttcccagg gctgaggatc catgccttct ttgtttctaa gttatctttc 19140 ccatagcttt tcattatctt tcatatgatc cagtatatgt taaatatgtc ctacatatac 19200 atttagacaa ccaccatttg ttaagtattt gctctaggac agagtttgga tttgtttatg 19260 tttgctcaaa aggagaccca tgggctctcc agggtgcact gagtcaatct agtcctaaaa 19320 agcaatctta ttattaactc tgtatgacag aatcatgtct ggaacttttg ttttctgctt 19380 tctgtcaagt ataaacttca ctttgatgct gtacttgcaa aatcacattt tctttctgga 19440 aattccggca gtgtaccttg actgctagct accctgtgcc agaaaagcct cattcgttgt 19500 gcttgaaccc ttgaatgcca ccagctgtca tcactacaca gccctcctaa gaggcttcct 19560 ggaggtttcg agattcagat gccctgggag atcccagagt ttcctttccc tcttggccat 19620 attctggtgt caatgacaag gagtaccttg gctttgccac atgtcaaggc tgaagaaaca 19680 gtgtctccaa cagagctcct tgtgttatct gtttgtacat gtgcatttgt acagtaattg 19740 gtgtgacagt gttctttgtg tgaattacag gcaagaattg tggctgagca aggcacatag 19800 tctactcagt ctattcctaa gtcctaactc ctccttgtgg tgttggattt gtaaggcact 19860 ttatcccttt tgtctcatgt ttcatcgtaa atggcatagg cagagatgat acctaattct 19920 gcatttgatt gtcacttttt gtacctgcat taatttaata aaatattctt atttattttg 19980 ttacttggta caccagcatg tccattttct tgtttatttt gtgtttaata aaatgttcag 20040 tttaacatcc cagtggagaa agtta 20065 <210> 44 <211> 3691 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..3691 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 44 ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag 60 gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt 120 gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc 180 aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta 240 gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt 300 attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg 360 gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg 420 aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag 480 cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg 540 gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa 600 gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc 660 aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac aacaactaat 720 gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac agctgaattg 780 gtcatcccag aactacctct ggcacatcct ccaaatgaaa ggactcactt ggtaattctg 840 ggagccatct tattatgcct tggtgtagca ctgacattca tcttccgttt aagaaaaggg 900 agaatgatgg atgtgaaaaa atgtggcatc caagatacaa actcaaagaa gcaaagtgat 960 acacatttgg aggagacgta atccagcatt ggaacttctg atcttcaagc agggattctc 1020 aacctgtggt ttaggggttc atcggggctg agcgtgacaa gaggaaggaa tgggcccgtg 1080 ggatgcaggc aatgtgggac ttaaaaggcc caagcactga aaatggaacc tggcgaaagc 1140 agaggaggag aatgaagaaa gatggagtca aacagggagc ctggagggag accttgatac 1200 tttcaaatgc ctgaggggct catcgacgcc tgtgacaggg agaaaggata cttctgaaca 1260 aggagcctcc aagcaaatca tccattgctc atcctaggaa gacgggttga gaatccctaa 1320 tttgagggtc agttcctgca gaagtgccct ttgcctccac tcaatgcctc aatttgtttt 1380 ctgcatgact gagagtctca gtgttggaac gggacagtat ttatgtatga gtttttccta 1440 tttattttga gtctgtgagg tcttcttgtc atgtgagtgt ggttgtgaat gatttctttt 1500 gaagatatat tgtagtagat gttacaattt tgtcgccaaa ctaaacttgc tgcttaatga 1560 tttgctcaca tctagtaaaa catggagtat ttgtaaggtg cttggtctcc tctataacta 1620 caagtataca ttggaagcat aaagatcaaa ccgttggttg cataggatgt cacctttatt 1680 taacccatta atactctggt tgacctaatc ttattctcag acctcaagtg tctgtgcagt 1740 atctgttcca tttaaatatc agctttacaa ttatgtggta gcctacacac ataatctcat 1800 ttcatcgctg taaccaccct gttgtgataa ccactattat tttacccatc gtacagctga 1860 ggaagcaaac agattaagta acttgcccaa accagtaaat agcagacctc agactgccac 1920 ccactgtcct tttataatac aatttacagc tatattttac tttaagcaat tcttttattc 1980 aaaaaccatt tattaagtgc ccttgcaata tcaatcgctg tgccaggcat tgaatctaca 2040 gatgtgagca agacaaagta cctgtcctca aggagctcat agtataatga ggagattaac 2100 aagaaaatgt attattacaa tttagtccag tgtcatagca taaggatgat gcgaggggaa 2160 aacccgagca gtgttgccaa gaggaggaaa taggccaatg tggtctggga cggttggata 2220 tacttaaaca tcttaataat cagagtaatt ttcatttaca aagagaggtc ggtacttaaa 2280 ataaccctga aaaataacac tggaattcct tttctagcat tatatttatt cctgatttgc 2340 ctttgccata taatctaatg cttgtttata tagtgtctgg tattgtttaa cagttctgtc 2400 ttttctattt aaatgccact aaattttaaa ttcatacctt tccatgattc aaaattcaaa 2460 agatcccatg ggagatggtt ggaaaatctc cacttcatcc tccaagccat tcaagtttcc 2520 tttccagaag caactgctac tgcctttcat tcatatgttc ttctaaagat agtctacatt 2580 tggaaatgta tgttaaaagc acgtattttt aaaatttttt tcctaaatag taacacattg 2640 tatgtctgct gtgtactttg ctatttttat ttattttagt gtttcttata tagcagatgg 2700 aatgaatttg aagttcccag ggctgaggat ccatgccttc tttgtttcta agttatcttt 2760 cccatagctt ttcattatct ttcatatgat ccagtatatg ttaaatatgt cctacatata 2820 catttagaca accaccattt gttaagtatt tgctctagga cagagtttgg atttgtttat 2880 gtttgctcaa aaggagaccc atgggctctc cagggtgcac tgagtcaatc tagtcctaaa 2940 aagcaatctt attattaact ctgtatgaca gaatcatgtc tggaactttt gttttctgct 3000 ttctgtcaag tataaacttc actttgatgc tgtacttgca aaatcacatt ttctttctgg 3060 aaattccggc agtgtacctt gactgctagc taccctgtgc cagaaaagcc tcattcgttg 3120 tgcttgaacc cttgaatgcc accagctgtc atcactacac agccctccta agaggcttcc 3180 tggaggtttc gagattcaga tgccctggga gatcccagag tttcctttcc ctcttggcca 3240 tattctggtg tcaatgacaa ggagtacctt ggctttgcca catgtcaagg ctgaagaaac 3300 agtgtctcca acagagctcc ttgtgttatc tgtttgtaca tgtgcatttg tacagtaatt 3360 ggtgtgacag tgttctttgt gtgaattaca ggcaagaatt gtggctgagc aaggcacata 3420 gtctactcag tctattccta agtcctaact cctccttgtg gtgttggatt tgtaaggcac 3480 tttatccctt ttgtctcatg tttcatcgta aatggcatag gcagagatga tacctaattc 3540 tgcatttgat tgtcactttt tgtacctgca ttaatttaat aaaatattct tatttatttt 3600 gttacttggt acaccagcat gtccattttc ttgtttattt tgtgtttaat aaaatgttca 3660 gtttaacatc ccagtggaga aagttaaaaa a 3691 <210> 45 <211> 290 <212> PRT <213> Homo sapiens <400> 45 Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 1 5 10 15 Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 20 25 30 Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 35 40 45 Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 50 55 60 Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 65 70 75 80 Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 85 90 95 Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 100 105 110 Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 115 120 125 Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 130 135 140 Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 145 150 155 160 Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 165 170 175 Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 180 185 190 Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 195 200 205 Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 210 215 220 Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 225 230 235 240 Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 245 250 255 Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 260 265 270 Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 275 280 285 Glu Thr 290 <210> 46 <211> 3349 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..3349 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 46 ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag 60 gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt 120 gctgtcttta tattcatgac ctactggcat ttgctgaacg ccccatacaa caaaatcaac 180 caaagaattt tggttgtgga tccagtcacc tctgaacatg aactgacatg tcaggctgag 240 ggctacccca aggccgaagt catctggaca agcagtgacc atcaagtcct gagtggtaag 300 accaccacca ccaattccaa gagagaggag aagcttttca atgtgaccag cacactgaga 360 atcaacacaa caactaatga gattttctac tgcactttta ggagattaga tcctgaggaa 420 aaccatacag ctgaattggt catcccagaa ctacctctgg cacatcctcc aaatgaaagg 480 actcacttgg taattctggg agccatctta ttatgccttg gtgtagcact gacattcatc 540 ttccgtttaa gaaaagggag aatgatggat gtgaaaaaat gtggcatcca agatacaaac 600 tcaaagaagc aaagtgatac acatttggag gagacgtaat ccagcattgg aacttctgat 660 cttcaagcag ggattctcaa cctgtggttt aggggttcat cggggctgag cgtgacaaga 720 ggaaggaatg ggcccgtggg atgcaggcaa tgtgggactt aaaaggccca agcactgaaa 780 atggaacctg gcgaaagcag aggaggagaa tgaagaaaga tggagtcaaa cagggagcct 840 ggagggagac cttgatactt tcaaatgcct gaggggctca tcgacgcctg tgacagggag 900 aaaggatact tctgaacaag gagcctccaa gcaaatcatc cattgctcat cctaggaaga 960 cgggttgaga atccctaatt tgagggtcag ttcctgcaga agtgcccttt gcctccactc 1020 aatgcctcaa tttgttttct gcatgactga gagtctcagt gttggaacgg gacagtattt 1080 atgtatgagt ttttcctatt tattttgagt ctgtgaggtc ttcttgtcat gtgagtgtgg 1140 ttgtgaatga tttcttttga agatatattg tagtagatgt tacaattttg tcgccaaact 1200 aaacttgctg cttaatgatt tgctcacatc tagtaaaaca tggagtattt gtaaggtgct 1260 tggtctcctc tataactaca agtatacatt ggaagcataa agatcaaacc gttggttgca 1320 taggatgtca cctttattta acccattaat actctggttg acctaatctt attctcagac 1380 ctcaagtgtc tgtgcagtat ctgttccatt taaatatcag ctttacaatt atgtggtagc 1440 ctacacacat aatctcattt catcgctgta accaccctgt tgtgataacc actattattt 1500 tacccatcgt acagctgagg aagcaaacag attaagtaac ttgcccaaac cagtaaatag 1560 cagacctcag actgccaccc actgtccttt tataatacaa tttacagcta tattttactt 1620 taagcaattc ttttattcaa aaaccattta ttaagtgccc ttgcaatatc aatcgctgtg 1680 ccaggcattg aatctacaga tgtgagcaag acaaagtacc tgtcctcaag gagctcatag 1740 tataatgagg agattaacaa gaaaatgtat tattacaatt tagtccagtg tcatagcata 1800 aggatgatgc gaggggaaaa cccgagcagt gttgccaaga ggaggaaata ggccaatgtg 1860 gtctgggacg gttggatata cttaaacatc ttaataatca gagtaatttt catttacaaa 1920 gagaggtcgg tacttaaaat aaccctgaaa aataacactg gaattccttt tctagcatta 1980 tatttattcc tgatttgcct ttgccatata atctaatgct tgtttatata gtgtctggta 2040 ttgtttaaca gttctgtctt ttctatttaa atgccactaa attttaaatt catacctttc 2100 catgattcaa aattcaaaag atcccatggg agatggttgg aaaatctcca cttcatcctc 2160 caagccattc aagtttcctt tccagaagca actgctactg cctttcattc atatgttctt 2220 ctaaagatag tctacatttg gaaatgtatg ttaaaagcac gtatttttaa aatttttttc 2280 ctaaatagta acacattgta tgtctgctgt gtactttgct atttttattt attttagtgt 2340 ttcttatata gcagatggaa tgaatttgaa gttcccaggg ctgaggatcc atgccttctt 2400 tgtttctaag ttatctttcc catagctttt cattatcttt catatgatcc agtatatgtt 2460 aaatatgtcc tacatataca tttagacaac caccatttgt taagtatttg ctctaggaca 2520 gagtttggat ttgtttatgt ttgctcaaaa ggagacccat gggctctcca gggtgcactg 2580 agtcaatcta gtcctaaaaa gcaatcttat tattaactct gtatgacaga atcatgtctg 2640 gaacttttgt tttctgcttt ctgtcaagta taaacttcac tttgatgctg tacttgcaaa 2700 atcacatttt ctttctggaa attccggcag tgtaccttga ctgctagcta ccctgtgcca 2760 gaaaagcctc attcgttgtg cttgaaccct tgaatgccac cagctgtcat cactacacag 2820 ccctcctaag aggcttcctg gaggtttcga gattcagatg ccctgggaga tcccagagtt 2880 tcctttccct cttggccata ttctggtgtc aatgacaagg agtaccttgg ctttgccaca 2940 tgtcaaggct gaagaaacag tgtctccaac agagctcctt gtgttatctg tttgtacatg 3000 tgcatttgta cagtaattgg tgtgacagtg ttctttgtgt gaattacagg caagaattgt 3060 ggctgagcaa ggcacatagt ctactcagtc tattcctaag tcctaactcc tccttgtggt 3120 gttggatttg taaggcactt tatccctttt gtctcatgtt tcatcgtaaa tggcataggc 3180 agagatgata cctaattctg catttgattg tcactttttg tacctgcatt aatttaataa 3240 aatattctta tttattttgt tacttggtac accagcatgt ccattttctt gtttattttg 3300 tgtttaataa aatgttcagt ttaacatccc agtggagaaa gttaaaaaa 3349 <210> 47 <211> 176 <212> PRT <213> Homo sapiens <400> 47 Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 1 5 10 15 Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 20 25 30 Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 35 40 45 Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 50 55 60 Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 65 70 75 80 Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 85 90 95 Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 100 105 110 Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 115 120 125 Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 130 135 140 Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 145 150 155 160 Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 165 170 175 <210> 48 <211> 3518 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..3518 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 48 ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag 60 gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt 120 gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc 180 aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta 240 gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt 300 attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg 360 gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg 420 aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag 480 cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg 540 gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa 600 gtcatctgga caagcagtga ccatcaagtc ctgagtggag attagatcct gaggaaaacc 660 atacagctga attggtcatc ccagaactac ctctggcaca tcctccaaat gaaaggactc 720 acttgggaga atgatggatg tgaaaaaatg tggcatccaa gatacaaact caaagaagca 780 aagtgataca catttggagg agacgtaatc cagcattgga acttctgatc ttcaagcagg 840 gattctcaac ctgtggttta ggggttcatc ggggctgagc gtgacaagag gaaggaatgg 900 gcccgtggga tgcaggcaat gtgggactta aaaggcccaa gcactgaaaa tggaacctgg 960 cgaaagcaga ggaggagaat gaagaaagat ggagtcaaac agggagcctg gagggagacc 1020 ttgatacttt caaatgcctg aggggctcat cgacgcctgt gacagggaga aaggatactt 1080 ctgaacaagg agcctccaag caaatcatcc attgctcatc ctaggaagac gggttgagaa 1140 tccctaattt gagggtcagt tcctgcagaa gtgccctttg cctccactca atgcctcaat 1200 ttgttttctg catgactgag agtctcagtg ttggaacggg acagtattta tgtatgagtt 1260 tttcctattt attttgagtc tgtgaggtct tcttgtcatg tgagtgtggt tgtgaatgat 1320 ttcttttgaa gatatattgt agtagatgtt acaattttgt cgccaaacta aacttgctgc 1380 ttaatgattt gctcacatct agtaaaacat ggagtatttg taaggtgctt ggtctcctct 1440 ataactacaa gtatacattg gaagcataaa gatcaaaccg ttggttgcat aggatgtcac 1500 ctttatttaa cccattaata ctctggttga cctaatctta ttctcagacc tcaagtgtct 1560 gtgcagtatc tgttccattt aaatatcagc tttacaatta tgtggtagcc tacacacata 1620 atctcatttc atcgctgtaa ccaccctgtt gtgataacca ctattatttt acccatcgta 1680 cagctgagga agcaaacaga ttaagtaact tgcccaaacc agtaaatagc agacctcaga 1740 ctgccaccca ctgtcctttt ataatacaat ttacagctat attttacttt aagcaattct 1800 tttattcaaa aaccatttat taagtgccct tgcaatatca atcgctgtgc caggcattga 1860 atctacagat gtgagcaaga caaagtacct gtcctcaagg agctcatagt ataatgagga 1920 gattaacaag aaaatgtatt attacaattt agtccagtgt catagcataa ggatgatgcg 1980 aggggaaaac ccgagcagtg ttgccaagag gaggaaatag gccaatgtgg tctgggacgg 2040 ttggatatac ttaaacatct taataatcag agtaattttc atttacaaag agaggtcggt 2100 acttaaaata accctgaaaa ataacactgg aattcctttt ctagcattat atttattcct 2160 gatttgcctt tgccatataa tctaatgctt gtttatatag tgtctggtat tgtttaacag 2220 ttctgtcttt tctatttaaa tgccactaaa ttttaaattc atacctttcc atgattcaaa 2280 attcaaaaga tcccatggga gatggttgga aaatctccac ttcatcctcc aagccattca 2340 agtttccttt ccagaagcaa ctgctactgc ctttcattca tatgttcttc taaagatagt 2400 ctacatttgg aaatgtatgt taaaagcacg tatttttaaa atttttttcc taaatagtaa 2460 cacattgtat gtctgctgtg tactttgcta tttttattta ttttagtgtt tcttatatag 2520 cagatggaat gaatttgaag ttcccagggc tgaggatcca tgccttcttt gtttctaagt 2580 tatctttccc atagcttttc attatctttc atatgatcca gtatatgtta aatatgtcct 2640 acatatacat ttagacaacc accatttgtt aagtatttgc tctaggacag agtttggatt 2700 tgtttatgtt tgctcaaaag gagacccatg ggctctccag ggtgcactga gtcaatctag 2760 tcctaaaaag caatcttatt attaactctg tatgacagaa tcatgtctgg aacttttgtt 2820 ttctgctttc tgtcaagtat aaacttcact ttgatgctgt acttgcaaaa tcacattttc 2880 tttctggaaa ttccggcagt gtaccttgac tgctagctac cctgtgccag aaaagcctca 2940 ttcgttgtgc ttgaaccctt gaatgccacc agctgtcatc actacacagc cctcctaaga 3000 ggcttcctgg aggtttcgag attcagatgc cctgggagat cccagagttt cctttccctc 3060 ttggccatat tctggtgtca atgacaagga gtaccttggc tttgccacat gtcaaggctg 3120 aagaaacagt gtctccaaca gagctccttg tgttatctgt ttgtacatgt gcatttgtac 3180 agtaattggt gtgacagtgt tctttgtgtg aattacaggc aagaattgtg gctgagcaag 3240 gcacatagtc tactcagtct attcctaagt cctaactcct ccttgtggtg ttggatttgt 3300 aaggcacttt atcccttttg tctcatgttt catcgtaaat ggcataggca gagatgatac 3360 ctaattctgc atttgattgt cactttttgt acctgcatta atttaataaa atattcttat 3420 ttattttgtt acttggtaca ccagcatgtc cattttcttg tttattttgt gtttaataaa 3480 atgttcagtt taacatccca gtggagaaag ttaaaaaa 3518 <210> 49 <211> 4972 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..4972 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 49 cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt 60 ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg 120 gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct 180 cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt 240 gtaagtatga ctttttaata gtacttgttt gtggttgaaa atgactgaat atcgacttgc 300 tgtagcatct ctgataggct gtcatctctt gtaggcagtc attttgagat ttggtgttat 360 tttgttaatt attgactaga tgagttcctt gactaaataa tctagatatt gttttaacct 420 tctgctcagt ttgtatagag acttaaaagg gatttatgaa ttttccaaaa gatgggcata 480 atatgggtat gaagcataat gatgttaata attttgtggt gggaactcat tcagttgtga 540 tagtcaagga gtatgcagat tgaaaaaaat gattggttat tagtttttga cttctcagac 600 tctaaggtca agattagcat taaaaaggta ataggaaatg tttacaaatt aaagtcaaaa 660 aggtccttaa agctttggct taaaaaaata actgataggt gattttctcc aaaaagtgat 720 ttcaacattc tgcttctcta tctatattac ttgtgaagta ttccggaact tcgttgctca 780 ctgggatttt ggaagaatta tgattctggc taaggaatgt ttaaaaattt taagtgaatt 840 ttttgagttt cttttaaaat tttattgatg gttaatgaaa agtttttaca ttttaaatat 900 ttcattattt gtttaaaact tagctgttat aattatagct gtcataataa tattcagaca 960 ttcacaattg attttattct tacaacacaa aatcaaatca cacacacaca cacacacaca 1020 cacacactcg cacatgtttg gaactatctt ttaaagctcg tataataata ccctacagga 1080 aggcacagta gatgtaatag aaacctgtac cattgggggg cagtatttta tagtggggtg 1140 gctttgctgt tttttgtttt tgtatttttt agcctagctt gaaaatactt tctttagctt 1200 actatagttt ttgggacctt tggagtatca gctttgttga gctcatttgt gacattgcaa 1260 tttaatggtt atattgggaa ataaaaaagc taaaagaaca taatagtctt tgtctatatc 1320 tcacataagc cttttgggaa tacttattgt tagaactaag cagaagagtt gaaaaggaaa 1380 tcagtgaata ttgtcacatc tgagttcaat gaaacttgaa atatattttt aaggcaattt 1440 atgggctaat tgtaaaccaa ttttttcttt tttttttttt agaatgcagg tcattcagat 1500 gtagcggata atggaactct tttcttaggc attttgaaga attggaaaga ggtaagctga 1560 atattcccat ttggctaatt ttcctgttgc ttgctttctg atggataaat tcacatcatc 1620 ctctgtttgt gctctttcct tccaaggaga gtgacagaaa aataatgcag agccaaattg 1680 tctcctttta cttcaaactt tttaaaaact ttaaagatga ccagagcatc caaaagagtg 1740 tggagaccat caaggaagac atgaatgtca agtttttcaa tagcaacaaa aagaaacgag 1800 atgacttcga aaagctgact aattattcgg tgaggctatt taaattcttt ctttggtttc 1860 attgccgagg gtcttgcaaa gcatttattc tccagaaagt agacattagc tatttaacag 1920 ttgctaaagc tatgaactca actcatggct gaaactctac cttactattt ccattcgtgt 1980 ttgggtgact ttgcaaagcc agtaagagaa tcgctgaagt atgtaatgta gagaaatgct 2040 ggcattgtaa ctattgcgta aagacaggtg agttgacaaa tccagtgaag aggaagtagg 2100 tgaggaagaa gcggggagta ctgagaagca gttctctcat tgtcccttgc tcatatgatg 2160 gaaattctct tactttgaat gagaggctgt ctgtcttaat ggaaagagca gtgggaggag 2220 ctgagaagat gtgtgttctc ctcccaactc agccaccaag gaactgtgat gaatcacatg 2280 gctggctggg gctcagtttc ctcatcttaa aaggaaactg ttaggctcac tgtataagtt 2340 tgatgacctt ctttgctcca aaactctaca atgcaaagaa tagaaaatga gaatgagata 2400 gaagaaagct acagtctttg aataggtacc agggacaccc cactgcaagt ctctagccaa 2460 cctatcagat tgtactgccc aattagaagc aagaatggtt gctgtttgtt tgtttttagg 2520 gaaaaataga tagaatttat accttatgaa aagattgttc tatcaactct ctatcaactt 2580 tcagaatatc tcagctggag aactccttag actcctaagt cttacctcat gaacttgtat 2640 ctttaagtta tggcttctat aaacagaaag ataacgttga ggcataaaga caaatcatgt 2700 ttttcaaaat gttttctaga agacaaaggc ctctagattc ctttggggtt gactttgata 2760 taaatgggct caaatgagag ggaccagggt cttcaagcta gcatttgtgt tcttaggata 2820 tgtgctcagc tttcactatt gctgggcctg cctctcactc ctctcatgta agcccccaga 2880 aacagaaagg agagacatgg caacaggtct cctttggtta taaactagac actcagcact 2940 tgtttctaat ccagtggtgc ccctggctta ctgttcagtc ctggataagt ctcttagttt 3000 cttggtgatg atttgaacat tggaaagtaa aatctgtcac ttgcaaacac acagcttgtc 3060 gaaaattttt tctactctgc aggaactggg ccttaaaaaa atgaaaaaaa atctgtggtt 3120 tcttccttct ggaagctaca aacctcctgt ttcttgatgg gcaatcttga gtgagctcta 3180 ttaattatta ttctctttgg ctcagttgct aagctatttt atgcatgtta tgccctttga 3240 caattagtct ttagctgtaa tcccccagcc atcctcagaa atgtggtgag tagccatagt 3300 gttcccaaga ttagaaaaaa tgtaatggca gagccaagag gaaggtaaat ggtccacatt 3360 ttatgaagca tcatctaaat ggccctattg gttagagtga ggagatgcaa gtagttcaat 3420 ttgcttgcct agaaggcagg gtactggaaa agttgttgca attcttaatt ttaaacttta 3480 tatatcagta agccatatat aaatatgatt gggggtgttt attttaaaat ctattatgga 3540 aattgagaga ctgacctaat ctgggagaaa ttaaaaatta cagttttcac tcgttttgga 3600 tttggtgttt tctagggtac ctaacctaga tcagtggttc tcaaacttag gtggatgtca 3660 gaatcacctg gggagcttag tgaatgcaca gggcacagtc cttccacttc atgcacctgg 3720 atctctgagg tctttgacag gtttccggat taatctgcta tgcacaacag tgagaatcat 3780 tgacctatag ttactcattt gatgcataca ggaaagactg aagtataaag tgatataatt 3840 ggtagattga tgatagagag gtcatagaaa cagtctcatc ctcctttaga tgagaaaata 3900 gaagttcaga gaggttaagt agctggctca aggtcagaat tattgcatgc atgagattca 3960 aacccacctt tttatgctga ctccacaacc aggagtcttt tcactatata atttcaagaa 4020 ttctatagaa gtagatttaa agatatgtga tggactccac cacattatag cacaactaga 4080 aatgtaattg taatttttag cttcaactgc tgaagaagta aatattgtat attaaggtaa 4140 tacggtccat tttttaaagg aatactttta ttttcactga ccatcatgac attagcagaa 4200 tatcctgatg gcttatatgc ctgaaattaa ttttgctctt ttctttcccg ataggtaact 4260 gacttgaatg tccaacgcaa agcaatacat gaactcatcc aagtgatggc tgaactgtcg 4320 ccagcagcta aaacagggaa gcgaaaaagg agtcagatgc tgtttcgagg tcgaagagca 4380 tcccagtaat ggttgtcctg cctgcaatat ttgaatttta aatctaaatc tatttattaa 4440 tatttaacat tatttatatg gggaatatat ttttagactc atcaatcaaa taagtattta 4500 taatagcaac ttttgtgtaa tgaaaatgaa tatctattaa tatatgtatt atttataatt 4560 cctatatcct gtgactgtct cacttaatcc tttgttttct gactaattag gcaaggctat 4620 gtgattacaa ggctttatct caggggccaa ctaggcagcc aacctaagca agatcccatg 4680 ggttgtgtgt ttatttcact tgatgataca atgaacactt ataagtgaag tgatactatc 4740 cagttactgc cggtttgaaa atatgcctgc aatctgagcc agtgctttaa tggcatgtca 4800 gacagaactt gaatgtgtca ggtgaccctg atgaaaacat agcatctcag gagatttcat 4860 gcctggtgct tccaaatatt gttgacaact gtgactgtac ccaaatggaa agtaactcat 4920 ttgttaaaat tatcaatatc taatatatat gaataaagtg taagttcaca ac 4972 <210> 50 <211> 1240 <212> DNA <213> Homo sapiens <220> <221> source <222> 1..1240 <223> /mol_type="unassigned DNA" /organism="Homo sapiens" <400> 50 cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt 60 ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg 120 gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct 180 cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt 240 aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat 300 tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa 360 ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa 420 gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg 480 actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa 540 gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg 600 tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa 660 tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat 720 caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata 780 tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga 840 ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa 900 cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat 960 aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag 1020 tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag 1080 catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc 1140 aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta 1200 agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1240 <210> 51 <211> 166 <212> PRT <213> Homo sapiens <400> 51 Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 1 5 10 15 Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 20 25 30 Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 35 40 45 Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 50 55 60 Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 65 70 75 80 Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 85 90 95 Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 100 105 110 Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 115 120 125 Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 130 135 140 Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 145 150 155 160 Gly Arg Arg Ala Ser Gln 165

Claims (88)

  1. 하기 단계를 포함하는, (i) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료가 고려되거나, (ii) HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제를 포함하는 치료를 받고 있는 암 환자에서 PD-L1 억제제 공동치료에 대한 필요를 결정하기 위한 정보를 제공하는 방법:
    a) 상기 환자로부터 수득된 샘플에서 에스트로겐 수용체(ER) 및 예정 사멸 리간드 1(PD-L1)의 발현 수준을 시험관내에서 측정하는 단계, 및
    b) 낮거나 부재하는 ER 발현 수준 및 대조군에 비해 증가된 예정 사멸 리간드 1(PD-L1)의 발현 수준이 단계 (a)에서 측정되는 경우, 상기 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 단계.
  2. 제 1 항에 있어서,
    상기 환자로부터 수득된 샘플에서 인터페론-감마(IFNγ)의 발현 수준을 시험관내에서 측정하고, 대조군에 비해 감소된 인터페론-감마(IFNγ)의 발현 수준이 측정되는 경우 환자가 PD-L1 억제제 공동치료를 필요로 하는 것으로 결정하는 것을 추가로 포함하는, 방법.
  3. 제 1 항에 있어서,
    ER 발현 수준이 ER(-)인, 방법 .
  4. 제 1 항에 있어서,
    상기 HER2/neu (ErbB2) 신호전달 경로의 조절제가 HER 박리의 억제제인, 방법.
  5. 제 4 항에 있어서,
    상기 HER 박리의 억제제가 HER2 박리 억제제인, 방법.
  6. 제 4 항에 있어서,
    상기 HER 박리의 억제제가 HER 헤테로이량체화 또는 HER 호모이량체화를 억제하는, 방법.
  7. 제 4 항에 있어서,
    상기 HER 박리의 억제제가 HER 항체인, 방법.
  8. 제 7 항에 있어서,
    상기 HER 항체가 EGFR, HER2 및 HER3으로 이루어진 군에서 선택된 HER 수용체에 결합하는, 방법.
  9. 제 8 항에 있어서,
    상기 항체가 HER2에 결합하는, 방법.
  10. 제 9 항에 있어서,
    상기 항체가 HER2 세포외 도메인의 서브도메인 IV에 결합하는, 방법.
  11. 제 7 항에 있어서,
    상기 HER 항체가 허셉틴/트라스투주맙인, 방법.
  12. 제 1 항에 있어서,
    상기 HER2/neu(ErbB2) 신호전달 경로의 조절제가 HER 이량체화/신호전달 억제제인, 방법.
  13. 제 12 항에 있어서,
    상기 HER 이량체화 억제제가 HER2 이량체화 억제제인, 방법.
  14. 제 12 항에 있어서,
    상기 HER 이량체화 억제제가 HER 헤테로이량체화 또는 HER 호모이량체화를 억제하는, 방법.
  15. 제 12 항에 있어서,
    상기 HER 이량체화 억제제가 항-HER 항체인, 방법.
  16. 제 15 항에 있어서,
    상기 항-HER 항체가 EGFR, HER2 및 HER3으로 이루어진 군에서 선택된 HER 수용체에 결합하는, 방법.
  17. 제 16 항에 있어서,
    상기 항체가 HER2에 결합하는, 방법.
  18. 제 17 항에 있어서,
    상기 항체가 HER2 세포외 도메인의 도메인 II에 결합하는, 방법.
  19. 제 18 항에 있어서,
    상기 항체가 HER2 세포외 도메인의 도메인 I, II 및 III 사이의 연결부에 결합하는, 방법.
  20. 제 15 항에 있어서,
    상기 항-HER 항체가 퍼투주맙인, 방법.
  21. 제 1 항에 있어서,
    상기 화학치료제가 탁솔 또는 탁솔 유도체인, 방법.
  22. 제 11 항에 있어서,
    상기 화학치료제가 탁솔 또는 탁솔 유도체인, 방법.
  23. 제 20 항에 있어서,
    상기 화학치료제가 탁솔 또는 탁솔 유도체인, 방법.
  24. 제 21 항에 있어서,
    상기 탁솔 유도체가 도세탁셀인, 방법.
  25. 제 1 항 내지 제 24 항 중 어느 한 항에 있어서,
    상기 예정 사멸 리간드 1(PD-L1)의 억제제가 PD-L1에 특이적으로 결합하는 항체(항-PD-L1 항체)인, 방법.
  26. 제 25 항에 있어서,
    상기 항체가 HVR-H1, HVR-H2 및 HVR-H3 서열을 포함하는 중쇄 가변 영역 폴리펩티드를 포함하고,
    (a) HVR-H1 서열이 GFTFSX1SWIH (서열번호: 1)이고;
    (b) HVR-H2 서열이 AWIX2PYGGSX3YYADSVKG (서열번호: 2)이고;
    (c) HVR-H3 서열이 RHWPGGFDY (서열번호: 3)이며;
    여기서 X1이 D 또는 G이고; X2가 S 또는 L이고; X3이 T 또는 S인, 방법
  27. 제 26 항에 있어서,
    X1이 D이고; X2가 S이고, X3이 T인, 방법.
  28. 제 26 항에 있어서,
    상기 폴리펩티드가 식: (HC-FR1)-(HVR-H1)-(HC-FR2)-(HVR-H2)-(HC-FR3)-(HVR-H3)-(HC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 중쇄 프레임워크 서열을 추가로 포함하는, 방법.
  29. 제 28 항에 있어서,
    프레임워크 서열이 인간 공통 프레임워크 서열로부터 유도되는, 방법.
  30. 제 29 항에 있어서,
    프레임워크 서열이 VH 아족 III 공통 프레임워크인, 방법.
  31. 제 30항에 있어서,
    프레임워크 서열들 중 하나 이상이 다음인 방법:
    HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고,
    HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고,
    HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고,
    HC-FR4는 WGQGTLVTVSA (서열번호: 7)이다.
  32. 제 26 항에 있어서,
    상기 중쇄 폴리펩티드가 HVR-L1, HVR-L2 및 HVR-L3을 포함하는 가변 영역 경쇄와 함께 존재하고,
    (a) HVR-L1 서열이 RASQX4X5X6TX7X8A (서열번호: 8)이고;
    (b) HVR-L2 서열이 SASX9LX10S (서열번호: 9)이고;
    (c) HVR-L3 서열이 QQX11X12X13X14PX15T (서열번호: 10)이며;
    여기서, X4가 D 또는 V이고; X5가 V 또는 I이고; X6이 S 또는 N이고; X7이 A 또는 F이고; X8이 V 또는 L이고; X9가 F 또는 T이고; X10이 Y 또는 A이며; X11이 Y, G, F 또는 S이고; X12가 L, Y, F 또는 W이고; X13이 Y, N, A, T, G, F 또는 I이고; X14가 H, V, P, T 또는 I이고; X15가 A, W, R, P 또는 T인, 방법.
  33. 제 32 항에 있어서,
    X4가 D이고; X5가 V이고; X6이 S이고; X7이 A이고; X8이 V이고; X9가 F이고; X10이 Y이고; X11이 Y이고; X12가 L이고; X13이 Y이고; X14가 H이고; X15가 A인, 방법.
  34. 제 32 항에 있어서,
    상기 폴리펩티드가 식: (LC-FR1)-(HVR-L1)-(LC-FR2)-(HVR-L2)-(LC-FR3)-(HVR-L3)-(LC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 경쇄 프레임워크 서열을 추가로 포함하는, 방법.
  35. 제 34 항에 있어서,
    프레임워크 서열이 인간 공통 프레임워크 서열로부터 유도되는, 방법.
  36. 제 34 항에 있어서,
    프레임워크 서열이 VL 카파 I 공통 프레임워크인, 방법.
  37. 제 36 항에 있어서,
    프레임워크 서열들 중 하나 이상이 다음인 방법:
    LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
    LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
    LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
    LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
  38. 제 26 항에 있어서,
    상기 항-PD-L1 항체가 중쇄 및 경쇄 가변 영역 서열을 포함하고,
    (a) 중쇄가 HVR-H1, HVR-H2 및 HVR-H3을 포함하고, 여기서,
    (i) HVR-H1 서열이 GFTFSX1SWIH (서열번호: 1)이고;
    (ii) HVR-H2 서열이 AWIX2PYGGSX3YYADSVKG (서열번호: 2)이고;
    (iii) HVR-H3 서열이 RHWPGGFDY (서열번호:3)이며;
    (b) 경쇄가 HVR-L1, HVR-L2 및 HVR-L3을 포함하고, 여기서,
    (iv) HVR-L1 서열이 RASQX4X5X6TX7X8A (서열번호: 8)이고;
    (v) HVR-L2 서열이 SASX9LX10S (서열번호: 9)이고;
    (vi) HVR-L3 서열이 QQX11X12X13X14PX15T (서열번호: 10)이며;
    여기서, X1이 D 또는 G이고; X2가 S 또는 L이고; X3이 T 또는 S이고; X4가 D 또는 V일 수 있고; X5가 V 또는 I일 수 있고; X6이 S 또는 N일 수 있고; X7이 A 또는 F일 수 있고; X8이 V 또는 L일 수 있고; X9가 F 또는 T일 수 있고; X10이 Y 또는 A일 수 있고; X11이 Y, G, F 또는 S일 수 있고; X12가 L, Y, F 또는 W일 수 있고; X13이 Y, N, A, T, G, F 또는 I일 수 있고; X14가 H, V, P, T 또는 I일 수 있고; X15가 A, W, R, P 또는 T일 수 있는 방법.
  39. 제 38 항에 있어서,
    X1이 D이고; X2가 S이고, X3이 T인, 방법.
  40. 제 38 항에 있어서,
    X4가 D이고, X5가 V이고, X6이 S이고, X7이 A이고, X8이 V이고, X9가 F이고, X10이 Y이고, X11이 Y이고, X12가 L이고, X13이 Y이고, X14가 H이고, X15가 A인, 방법.
  41. 제 38 항에 있어서,
    X1이 D이고, X2가 S이고, X3이 T이고, X4가 D이고, X5가 V이고, X6이 S이고, X7이 A이고, X8이 V이고, X9가 F이고, X10이 Y이고, X11이 Y이고, X12가 L이고, X13이 Y이고, X14가 H이고, X15가 A인, 방법.
  42. 제 38 항에 있어서,
    항체가 추가로 다음을 포함하는, 방법:
    (a) 식: (HC-FR1)-(HVR-H1)-(HC-FR2)-(HVR-H2)-(HC-FR3)-(HVR-H3)-(HC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 중쇄 프레임워크 서열, 및
    (b) 식: (LC-FR1)-(HVR-L1)-(LC-FR2)-(HVR-L2)-(LC-FR3)-(HVR-L3)-(LC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 경쇄 프레임워크 서열.
  43. 제 42 항에 있어서,
    프레임워크 서열이 인간 공통 프레임워크 서열로부터 유도되는, 방법.
  44. 제 43 항에 있어서,
    가변 영역 중쇄 프레임워크 서열이 VH 아족 III 공통 프레임워크인, 방법.
  45. 제 44 항에 있어서,
    프레임워크 서열들 중 하나 이상이 다음인, 방법:
    HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고,
    HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고,
    HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고,
    HC-FR4는 WGQGTLVTVSA (서열번호: 7)이다.
  46. 제 43 항에 있어서,
    가변 영역 경쇄 프레임워크 서열이 VL 카파 I 공통 프레임워크인, 방법.
  47. 제 46 항에 있어서,
    프레임워크 서열들 중 하나 이상이 다음인, 방법:
    LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
    LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
    LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
    LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
  48. 제 43 항에 있어서,
    (a) 가변 중쇄 프레임워크 서열이 다음이고:
    (i) HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고;
    (ii) HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고;
    (iii) HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고;
    (iv) HC-FR4는 WGQGTLVTVSA (서열번호: 7)이며;
    (b) 가변 경쇄 프레임워크 서열이 다음인, 방법:
    (i) LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
    (ii) LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
    (iii) LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
    (iv) LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
  49. 제 48 항에 있어서,
    항체가 인간 불변 영역을 추가로 포함하는, 방법.
  50. 제 49 항에 있어서,
    불변 영역이 IgG1, IgG2, IgG3 및 IgG4로 이루어진 군에서 선택되는, 방법.
  51. 제 50 항에 있어서,
    불변 영역이 IgG1인, 방법.
  52. 제 48 항에 있어서,
    항체가 뮤린 불변 영역을 추가로 포함하는, 방법.
  53. 제 52 항에 있어서,
    불변 영역이 IgG1, IgG2A, IgG2B 및 IgG3으로 이루어진 군에서 선택되는 방법.
  54. 제 53 항에 있어서,
    불변 영역이 IgG2A인, 방법.
  55. 제 50 항에 있어서,
    상기 항체가 감소되거나 또는 최소 작동인자 기능을 갖는, 방법.
  56. 제 55 항에 있어서,
    최소 작동인자 기능이 작동인자-배제 Fc 돌연변이로부터 야기되는, 방법.
  57. 제 56 항에 있어서,
    작동인자-배제 Fc 돌연변이가 N297A인, 방법.
  58. 제 56 항에 있어서,
    작동인자-배제 Fc 돌연변이가 D265A/N297A인, 방법.
  59. 제 55 항에 있어서,
    최소 작동인자 기능이 비글리코실화로부터 야기되는, 방법.
  60. 제 26 항에 있어서,
    상기 항체가 중쇄 및 경쇄 가변 영역 서열을 포함하며,
    (a) 중쇄가 GFTFSDSWIH (서열번호: 15), AWISPYGGSTYYADSVKG (서열번호: 16) 및 RHWPGGFDY (서열번호: 3)에 대해 각각 85% 이상의 전체 서열 동일성을 갖는 HVR-H1, HVR-H2 및 HVR-H3을 포함하고,
    (b) 경쇄가 RASQDVSTAVA (서열번호: 17), SASFLYS (서열번호: 18) 및 QQYLYHPAT (서열번호: 19)에 대해 각각 85% 이상의 전체 서열 동일성을 갖는 HVR-L1, HVR-L2 및 HVR-L3을 포함하는, 방법.
  61. 제 60 항에 있어서,
    서열 동일성이 90% 이상인, 방법.
  62. 제 61 항에 있어서,
    상기 항체가 다음을 추가로 포함하는, 방법:
    (a) 식: (HC-FR1)-(HVR-H1)-(HC-FR2)-(HVR-H2)-(HC-FR3)-(HVR-H3)-(HC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 중쇄(VH) 프레임워크 서열, 및
    (b) 식: (LC-FR1)-(HVR-L1)-(LC-FR2)-(HVR-L2)-(LC-FR3)-(HVR-L3)-(LC-FR4)에 따라 HVR들 사이에 병렬배치된 가변 영역 경쇄(VL) 프레임워크 서열.
  63. 제 62 항에 있어서,
    상기 항체가 인간 공통 서열로부터 유도된 VH 및 VL 프레임워크 영역을 추가로 포함하는, 방법.
  64. 제 63 항에 있어서,
    VH 프레임워크 서열이 카밧 아족 I, II 또는 III 서열로부터 유도되는, 방법.
  65. 제 64 항에 있어서,
    VH 프레임워크 서열이 카밧 아족 III 공통 프레임워크 서열인, 방법.
  66. 제 65 항에 있어서,
    VH 프레임워크 서열이 다음인, 방법:
    HC-FR1은 EVQLVESGGGLVQPGGSLRLSCAAS (서열번호: 4)이고,
    HC-FR2는 WVRQAPGKGLEWV (서열번호: 5)이고,
    HC-FR3은 RFTISADTSKNTAYLQMNSLRAEDTAVYYCAR (서열번호: 6)이고,
    HC-FR4는 WGQGTLVTVSA (서열번호: 7)이다.
  67. 제 62 항에 있어서,
    VL 프레임워크 서열이 카밧 카파 I, II, III 또는 IV 아족 서열로부터 유도되는, 방법.
  68. 제 67 항에 있어서,
    VL 프레임워크 서열이 카밧 카파 I 공통 프레임워크 서열인, 방법.
  69. 제 68 항에 있어서,
    VL 프레임워크 서열이 다음인, 방법:
    LC-FR1은 DIQMTQSPSSLSASVGDRVTITC (서열번호: 11)이고;
    LC-FR2는 WYQQKPGKAPKLLIY (서열번호: 12)이고;
    LC-FR3은 GVPSRFSGSGSGTDFTLTISSLQPEDFATYYC (서열번호: 13)이고;
    LC-FR4는 FGQGTKVEIKR (서열번호: 14)이다.
  70. 제 26 항에 있어서,
    상기 항체가 중쇄 및 경쇄 가변 영역 서열을 포함하고,
    (a) 중쇄 서열이 중쇄 서열: EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPG KGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSA (서열번호: 20)에 대해 85% 이상의 서열 동일성을 가지고,
    (b) 경쇄 서열이 경쇄 서열: DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGK APKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKR(서열번호: 21)에 대해 85% 이상의 서열 동일성을 갖는, 방법.
  71. 제 70 항에 있어서,
    서열 동일성이 90% 이상인, 방법.
  72. 제 26 항에 있어서,
    상기 항체가 중쇄 및 경쇄 가변 영역 서열을 포함하고,
    (a) 중쇄가 서열: EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWIS PYGGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSA(서열번호: 20)을 포함하고,
    (b) 경쇄가 서열: DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSA SFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIKR(서열번호: 21)을 포함하는, 방법.
  73. 제 25 항에 있어서,
    상기 암이 고형암인, 방법.
  74. 제 73 항에 있어서,
    상기 고형암이 유방암 또는 위암인, 방법.
  75. 제 73 항에 있어서,
    상기 고형암이 유방암인, 방법.
  76. 제 75 항에 있어서,
    상기 유방암이 초기 단계 유방암인, 방법.
  77. 제 1 항에 있어서,
    PD-L1의 발현 수준이 아피메트릭스와 같은 통상적인 방법에 의해 측정하여 5.3 이상인, 방법.
  78. 제 1 항에 있어서,
    PD-L1의 발현 수준이 mRNA 발현 수준인, 방법.
  79. 제 78 항에 있어서,
    PD-L1의 mRNA 발현 수준이 원위치(in situ) 하이브리드화, 마이크로어레이 또는 실시간 PCR에 의해 평가되는, 방법.
  80. 제 1 항에 있어서,
    PD-L1의 발현 수준이 단백질 발현 수준인, 방법.
  81. 제 80 항에 있어서,
    PD-L1의 상기 단백질 발현 수준이 면역분석법, 겔- 또는 블롯-기반 방법, IHC, 질량분석법, 유세포분석 또는 FACS에 의해 평가되는, 방법.
  82. 제 1 항에 있어서,
    치료될 환자가 인간인, 방법.
  83. HER2/neu (ErbB2) 신호전달 경로의 조절제 및 화학치료제와 함께 PD-L1 억제제 공동치료에 대한 환자의 필요를 결정하기 위한, ER, PD-L1 및 선택적으로 IFNγ의 발현 수준을 검출할 수 있는 핵산 또는 항체를 포함하는, 제 1 항의 방법을 수행하기 위한 진단용 조성물.
  84. ER, PD-L1, 및 선택적으로 IFNγ의 발현 수준을 검출할 수 있는 핵산 또는 항체를 포함하는, 제 1 항의 방법을 수행하는데 유용한 키트.
  85. 제 1 항에 있어서,
    상기 HER2/neu (ErbB2) 신호전달 경로의 조절제, 상기 화학치료제 및 상기 예정 사멸 리간드 1(PD-L1)의 억제제가 선행보조요법(neoadjuvant) 환경 또는 보조요법 환경 또는 전이 환경에서 투여되기 위한 것인, 방법.
  86. 삭제
  87. 삭제
  88. 삭제
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