KR102522028B1 - Manufacturing Method of High Concentrated Nitric Oxide Bubbles in Water and High Concentrated Nitric Oxide Bubble Water Manufactured Therefrom - Google Patents

Abstract

The present invention can control the physical properties of one or more nitric oxide nanobubble numbers selected from the size of nitrogen oxide bubbles and the concentration of nitric oxide bubbles, and a high concentration of nitrogen oxide nanobubbles can exist at a high concentration and stably for a long period of time. In detail, it relates to a method for producing nitric oxide (NO) nanobubble water, a) in a bubble water production tank, the raw material containing nitrogen oxide microbubbles generates fine droplets in the gravity direction by a spray nozzle located on the upper part of the production tank. spraying in the form; and b) supplying nitrogen oxide gas into the production tank and bringing it into contact with the sprayed fine droplets.

Description

Manufacturing Method of High Concentrated Nitric Oxide Bubbles in Water and High Concentrated Nitric Oxide Bubble Water Manufactured Therefrom}

The present invention relates to a method for producing high-concentration nitric oxide nanobubble water and the high-concentration nitric oxide nanobubble water produced thereby, and in detail, to a method for producing high-concentration nitric oxide nanobubble water in which nitric oxide nanobubbles are highly dissolved and produced thereby It relates to high-concentration nitric oxide nanobubble water.

Nitric Oxide (NO) is a substance produced by arterial endothelial cells in the human body, and is known to be involved in vasodilation, blood flow promotion, and blood coagulation prevention, as well as regulating blood pressure in the human body, as well as enhancing immunity and antibacterial activity. there is.

In particular, nitric oxide is known as an essential endogenous substance for the human body's defense mechanism to prevent microbial infection. Inhibit the growth or kill the target pathogen.

However, since nitric oxide having the aforementioned antipathogenic and/or antiviral effects exists as a gas at room temperature, its use for treatment purposes is limited. In particular, it is not easy to apply nitric oxide gas to treat wounds occurring inside the human body.

As a means to solve this problem, Korean Patent Registration No. 10-1802512 provides nitrogen oxide ice through a refrigeration device after dissolving nitrogen oxide gas in water. There are concerns, additional processes are required for the production, storage and transportation of nitric oxide ice, as well as additional economic burdens.

Therefore, there is a need to provide a method capable of stably storing a large amount of biomedically valuable nitric oxide and supplying it to the affected part in the human body when needed.

Republic of Korea Patent No. 10-1802512

An object of the present invention is to provide a method for producing high-concentration nitric oxide nanobubble water containing high-concentration nitric oxide nanobubbles.

Another object of the present invention is to provide a method for producing high-concentration nitric oxide nanobubble water capable of maximizing the number of nitrogen oxide bubbles remaining in the nitric oxide nanobubble water.

Another object of the present invention is to provide a method for producing high-concentration nitric oxide nanobubble water capable of controlling the physical properties of one or more nitric oxide nanobubble water selected from the size and concentration of nitric oxide bubbles.

Another object of the present invention is to provide a method for producing high-concentration nitric oxide nanobubble water in which high-concentration nitric oxide nanobubbles stably exist.

Another object of the present invention is to provide high-concentration nitric oxide nanobubble water capable of storing nitric oxide nanobubbles for a long period of time.

A method for producing high concentration nitric oxide (NO) nanobubble water according to an aspect of the present invention is a) in a bubble water production tank, the raw material containing nitrogen oxide microbubbles is directed in the direction of gravity by a spray nozzle located on the top of the production tank. spraying in the form of fine droplets; and b) supplying nitrogen oxide gas into the preparation tank to contact the sprayed fine droplets.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the raw water may be discontinuously injected in the step of spraying the raw water in the form of fine droplets.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, discontinuous spraying may occur while bubbles included in the raw water are compressed and pass through a spray nozzle including fine holes.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, before the raw water is sprayed, the step of filtering the raw water to remove micro bubbles of 50 μm or more included in the raw water may be further included. there is.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the nitrogen oxide gas supplied into the production tank may be heated to a temperature of 20 to 200 ° C and then supplied.

The physical properties of at least one nitric oxide nanobubble water selected from the size and concentration of nitrogen oxide bubbles included in the high-concentration nitric oxide nanobubble water according to an embodiment of the present invention are characterized by filtering and oxidizing the supplied raw water. It can be controlled by any one or more factors selected from the heating degree of nitrogen gas.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, before the step of spraying the raw water in the form of fine droplets, the step of removing the dissolved gas contained in the water used for preparing the raw water can include more.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, dissolved gas may be removed through a bubbling process of a gas removing agent.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, a vacuum degassing process may be further performed after the bubbling process is performed.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, steps a) and b) are repeatedly performed to determine the size of nitrogen oxide bubbles and the size of nitrogen oxide bubbles included in the nitric oxide nanobubble water. The physical properties of one or more nitric oxide nanobubble numbers selected from concentrations can be controlled by the number of repetitions.

In the method for producing high-concentration nitric oxide nanobubbles according to an embodiment of the present invention, the average particle diameter of nitrogen oxide bubbles may be 200 nm or less.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the step of stabilizing the nitrogen oxide bubbles may be further included after the step of colliding droplets contacted with the nitrogen oxide gas on the uneven surface. .

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the nitric oxide bubbles may be stabilized by supplying a bubble stabilizer.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the bubble stabilizer may be at least one selected from metal ions, vitamins, cationic polymers, and mixtures thereof.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the concentration of nitrogen oxide bubbles can be maintained at 60% or more even after heating the high-concentration nitric oxide nanobubble water for 10 minutes.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the inside of the bubble water production tank is located in contact with one side of the bubble water production tank with a vertex and a bottom surface opposite to the vertex. A concavo-convex surface including a plurality of concave-convex acids may be further included.

In the method for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention, the angle between the reference line passing from the vertex of the concave mountain to the center point of the bottom surface and one side line of the bubble water production tank in the direction of gravity ranges from 1 to 10. It can be 90 degrees.

According to another aspect of the present invention, high-concentration nitric oxide nanobubbles containing a bubble stabilizer, having an average particle diameter of 200 nm or less, and including 10 ⁶ to 2 X 10 ⁹ nitric oxide nanobubbles per 1ml of nitric oxide nanobubbles. Gives the number of bubbles.

The concentration of nitrogen oxide bubbles contained in the high-concentration nitric oxide nanobubble water according to an embodiment of the present invention can be maintained at 60% or more even after heating the high-concentration nitric oxide nanobubble water for 10 minutes.

The method for producing high-concentration nitric oxide nanobubble water according to the present invention can provide high-concentration nitric oxide nanobubble water containing a high concentration of nitric oxide nanobubbles.

Furthermore, the method for producing high-concentration nitric oxide nanobubble water according to the present invention can provide high-concentration nitric oxide nanobubble water in which nitrogen oxide nanobubbles having an average particle diameter of 200 nm or less stably exist without a separate cooling process or a refrigeration device.

1 is a conceptual diagram showing an apparatus for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention.
2 is a conceptual diagram showing an apparatus for producing high-concentration nitric oxide nanobubble water according to another embodiment of the present invention.
3 is a schematic view of an injection nozzle 200 according to an embodiment of the present invention.
4 is a schematic diagram of a bubble water production tank 100 according to an embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, a method for producing high-concentration nitric oxide (NO) nanobubble water of the present invention will be described in detail. The drawings introduced below are provided as examples to sufficiently convey the spirit of the present invention to those skilled in the art. Therefore, the present invention may be embodied in other forms without being limited to the drawings presented below, and the drawings presented below may be exaggerated to clarify the spirit of the present invention. At this time, unless there is another definition in the technical terms and scientific terms used, they have meanings commonly understood by those of ordinary skill in the art to which this invention belongs, and the gist of the present invention in the following description and accompanying drawings Descriptions of well-known functions and configurations that may be unnecessarily obscure are omitted.

In the following description, terms such as first and second are terms used to describe various components, and are not limited in meaning per se, and are used only for the purpose of distinguishing one component from another.

Also, the singular forms used in the specification and appended claims may be intended to include the plural forms as well, unless the context dictates otherwise.

In addition, terms such as "include", "include" or "have" described below are intended to designate that features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist. should be construed, and understood not to preclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

First, for ease of understanding prior to describing the present invention, bubbles described below mean gas contained in a liquid, and the number of bubbles is defined as a mixture of bubbles and liquid.

Also, the number of high-concentration nitric oxide nanobubbles may refer to a number in which the number of nitric oxide nanobubbles per 1ml of the nitric oxide nanobubble number is 10 ⁵ or more.

A method for producing high-concentration nitric oxide nanobubble water according to an aspect of the present invention is a) in a bubble water production tank 100, raw water containing nitrogen oxide microbubbles is gravity by a spray nozzle 200 located at the top of the production tank spraying in the form of fine droplets in a direction; and b) supplying nitrogen oxide gas into the bubble water production tank 100 to contact the sprayed fine droplets.

In detail, raw water containing nitrogen oxide microbubbles is sprayed in the form of fine droplets by the spray nozzle 200 in the direction of gravity from the top of the bubble water production tank 100, and at this time, the bubble water production tank 100 The nitrogen oxide gas supplied therein comes into contact with the sprayed fine droplets. As the surface area of the liquid droplets refined by the injection nozzle 200 increases, the contact with the supplied nitrogen oxide gas increases, and the fine droplets in contact with the nitrogen oxide gas flow in the gravitational direction by gravity, and the supplied nitrogen oxide gas and After a large amount of nitrogen oxide gas is adsorbed on the surface of the microdroplets through additional contact, high-concentration nitrogen oxide nanobubbles containing finer and more uniformly sized nitrogen oxide nanobubbles are produced by a gas-liquid phase separation mechanism. Bubble water is produced.

Conventionally, in order to stably store the prepared nitric oxide bubble water, that is, to maintain the concentration of nitrogen oxide contained in the nitric oxide bubble water, a cooling device is used to suppress the molecular movement of nitrogen oxide contained in the nitric oxide bubble water. However, it is necessary to thaw the nitric oxide ice for practical use of the nitric oxide bubble water, and the concentration of nitric oxide contained in the nitric oxide bubble water may decrease during the thawing process. has a downside

However, in the high-concentration nitric oxide nanobubble water prepared according to the method for producing high-concentration nitric oxide nanobubble water of the present invention, the nitric oxide nanobubbles within the nitric oxide nanobubble water do not have a separate cooling process or a refrigeration device, and Brownian motion occurs. It has the advantage of being able to exist stably for a long time while doing.

That is, the method for producing high-concentration nitric oxide nanobubble water of the present invention is an additional method for preventing the decrease in solubility of nitrogen oxide gas due to gas molecule movement of nitrogen oxide included in the conventional nitrogen oxide bubble water and pressure and temperature change. It is possible to provide high-concentration nitric oxide nanobubble water that does not require a process and prevents economic loss due to this, as well as stably maintaining the concentration of nitrogen oxide for a long period of time.

Hereinafter, a method for producing high-concentration nitric oxide nanobubble water provided in one aspect of the present invention will be described in detail for each step.

A method for producing high-concentration nitrogen oxide nanobubble water according to an aspect of the present invention includes a spray nozzle 200 in which raw water containing nitrogen oxide micro-bubbles in a bubble water production tank 100 is located above the bubble water production tank 100 It may include a step of spraying in the form of fine droplets in the direction of gravity by the.

In one embodiment of the present invention, the raw water may be discontinuously injected.

Here, the discontinuous injection may mean that the raw water passing through the injection nozzle 200 is irregularly injected through the discharge port of the injection nozzle 200 .

In one embodiment, the discontinuous injection may occur while the bubbles included in the raw water are compressed and pass through the injection nozzle 200 including fine holes.

The bubbles included in the raw water have compressibility, and when compressed in the raw water and then injected through the injection nozzle 200, the raw water may be discontinuously injected due to the space of the compressed bubbles. This discontinuous injection has the effect of spraying the raw material water in the form of droplets through the injection nozzle 200 at high pressure, so that finer droplets can be made.

In one specific example, the spray nozzle 200 may be positioned above the bubble water production tank 100 in a tapered shape in which an area where the raw water is discharged becomes smaller.

As the injection nozzle 200 has a tapered shape, the compressibility of the air bubbles included in the raw water can be increased, and thus the raw water can be passed through the discharge port of the injection nozzle 200 under high pressure. It can be injected in the form of fine droplets. The liquid droplet ejected through the spray nozzle 200 may be miniaturized and contact with a nitrogen oxide gas to be described later may be increased by an increased surface area, which may be advantageous in forming nitric oxide nanobubbles.

For example, the injection nozzle 200 may include one or a plurality of fine holes through which raw water passes.

In one embodiment, the diameter of the micro hole may be 0.1 to 20 mm, preferably 0.1 to 10 mm, and more preferably 0.1 to 1 mm.

In order to spray the raw water that passes through the injection nozzle 200 discontinuously in the form of fine droplets due to the compression of bubbles contained in the raw water, it is necessary that the diameter of the fine holes included in the injection nozzle 200 have the above range. desirable.

In addition, the location of the micro-holes is not limited, but the ejection direction of the micro-droplets can be controlled according to the positions of the micro-holes, so that the sprayed micro-droplets, which will be described later, come into contact with the nitrogen oxide gas supplied into the bubble water production tank 100. In order to increase the probability of collision with the surface, it is advantageous that the micro-holes are positioned so that the micro-droplets can be sprayed in the direction of the concave-convex surface included in the bubble water production tank 100.

According to one embodiment of the present invention, the raw water may include nitric oxide microbubbles.

For example, the microbubble may have a size of 0.1 μm to 500 μm, specifically 1 μm to 200 μm, and more specifically 10 μm to 100 μm.

In order to spray the raw water passing through the spray nozzle 200 in the form of fine droplets through discontinuous injection of the raw water, the size of the nitrogen oxide microbubbles included in the raw water preferably satisfies the above range. For example, bubbles of 500 μm or more rapidly rise to the surface of the raw water due to high buoyancy and burst, so that the bubbles to be compressed existing in the raw water are reduced and the pressure when the raw water is injected to the outlet of the injection nozzle 200 can be reduced. However, since the raw water contains micro bubbles within the above range, it is possible to enable discontinuous injection by compressing the micro bubbles included in the raw water, and the raw water passing through the injection nozzle 200 at high pressure is injected in the form of fine droplets. can be advantageous in doing so.

1 is a conceptual diagram showing an apparatus for producing high-concentration nitric oxide nanobubble water according to an embodiment of the present invention.

As shown in FIG. 1, the raw water filled in the bubble water production tank 100 is supplied to the spray nozzle 200 by the pressure pump 500, which again passes through the spray nozzle 200 in the form of fine droplets. At this time, the nitrogen oxide gas is supplied into the bubble water production tank 100 and comes into contact with the sprayed liquid droplets, and then collides with the uneven surface including the plurality of first uneven mountains 110 so that the nitrogen oxide nanobubbles can be watered. that can be manufactured.

At this time, raw water may be produced in a separate raw water production tank (not shown) and then supplied to the bubble water production tank 100, and may be produced in the bubble water production tank 100, of course.

When raw water is produced in the bubble water production tank 100, water may be supplied through a water supply line (not shown) connected to the bubble water production tank 100 to fill the bubble water production tank 100 with water. there is.

For example, the volume of water filled in the bubble water production tank 100 may be 20 to 90% of the total volume of the bubble water production tank 100, specifically 30 to 80%, and more specifically 40 to 60%. % can be

The space excluding the water filled in the bubble water production tank 100, that is, filled with water, but the bubble water production tank 100 may include an empty space at the top, which is oxidized through the gas inlet pipe 300 into the empty space. Nitrogen gas can be supplied.

By bringing the supplied nitrogen oxide gas into contact with water, raw water in which the nitrogen oxide gas is dissolved in water can be formed. It can be supplied to be 2 bar.

The microbubbles included in the raw water supply nitrogen oxide gas through the gas inlet pipe 300 until it has the above-described internal pressure range of the bubble water production tank 100, and then the bubble water through the vacuum pump 600 It can be formed by nitrogen oxide dissolved in water by reducing the pressure inside the production tank 100.

At this time, the reduced pressure may be reduced to a level of 10 to 80%, specifically 20 to 70%, more specifically, a level of 30 to 60% from the pressure for forming the raw water.

Depending on the pressure reduction conditions, the size of the nitrogen oxide microbubbles included in the raw water may be formed in various ways. good night. In addition, bubbles with a size of 500 μm or more have a large buoyancy in the nitrogen oxide bubble water and rise rapidly toward the surface of the water, eventually bursting at the surface of the water. The generation of existing air bubbles can be effectively suppressed.

As an embodiment of the present invention, before the step of spraying the raw water in the form of fine droplets, a step of removing dissolved gas contained in water used for preparing the raw water may be further included.

The dissolved gas contained in water may mean a gas in a molecular state dissolved in water, and may include, for example, oxygen, nitrogen, carbon dioxide, etc., but may include all gases dissolved in water and existing in a molecular state. Not limited to this.

Nitric oxide gas, an odd-numbered electron molecule, has a strong tendency to gain or lose electrons, so it is easy to form ions such as NO ⁺ or NO ^- and has a very high chemical reactivity. Since nitrogen dioxide (NO ₂ ) may be formed by the nitrogen dioxide (NO 2 ), the concentration of dissolved nitrogen oxide in the water may decrease over time by reacting with the dissolved gas in the water.

Accordingly, by removing dissolved gases including oxygen contained in water used for the production of raw water in advance, chemical oxidation of nitrogen oxide that may occur in water is prevented, and nitrogen oxide can be stably stored for a long period of time, Since the number of nitrogen oxide nanobubbles can be maximized by reducing the dissolved gas contained in the water, there is an advantage of providing nitric oxide nanobubble water containing a high concentration of nitrogen oxide bubbles.

Dissolved gas contained in water can be removed by physical methods such as vacuum deaeration, thermal deaeration, and membrane deaeration, or chemical methods using reducing agents such as sodium sulfite or hydrazine. However, since dissolved gas in water can be effectively removed, the present invention is not limited thereto.

In one embodiment, dissolved gas can be effectively removed through a bubbling process of a gas removing agent.

For example, the gas removing agent for bubbling may be supplied into the bubble water production tank 100 through the gas inlet pipe 300 as shown in FIG. Of course, it can be supplied directly to .

In one embodiment, the gas removing agent may be at least one selected from hydrogen, helium, neon, argon, and mixtures thereof.

In another embodiment, the gas scavenger may have a density value lower than that of oxygen, and the compared density value may be a density value at 0°C and 1 atm.

Specifically, dissolved gas in water can be removed by bubbling a degassing agent having a density of 5 to 80% of the oxygen density value, preferably by bubbling a degassing agent having a density of 5 to 65% of the oxygen density value. or, better, by bubbling a degassing agent having a density of 5 to 20% of the oxygen density value.

The degassing agent having a lower density value than the oxygen density value can effectively remove the dissolved gas contained in the water because it is easy to float, and can also increase the dissolved amount of nitrogen oxide because it is advantageous for removing the degassing agent to be described later. Therefore, it may be advantageous for the density value of the gas scavenger to have the above range.

In one embodiment of the present invention, after performing the bubbling process for removing oxygen contained in the water, a vacuum degassing process for removing the gas removing agent may be further performed.

As shown in FIG. 2 , vacuum degassing may be performed by a vacuum pump 600 connected to one end of the gas inlet pipe 300 .

After removing the dissolved gas contained in the water, the remaining gas removing agent may be degassed by reducing the pressure with vacuum. As described above, since the degassing agent is easily floated in water, it may be advantageous for removal through vacuum degassing, and since the degassing agent is removed, a defect space between water molecules may be secured, thereby increasing the dissolved amount of nitrogen oxide. You can have the advantages of doing it.

In one embodiment of the present invention, raw water may be pumped by the pressure pump 500 and supplied to the spray nozzle 200 along the bubble water circulation pipe 400 .

At this time, the pressure pump 500 may use a pump of 1 to 5 horsepower, specifically, a pump of 1 to 3 horsepower may be used, but the present invention is not limited thereto. However, the diameter of the bubble water circulation pipe 400 may be 5 to 50 mm, preferably 10 to 30 mm, and more preferably 10 to 15 mm.

A raw material due to compression of the nitric oxide microbubbles contained in the raw material water in order to form more refined nitrogen oxide bubbles by colliding with one wall surface including the first concave-convex acid 110 of the bubble water production tank 100 to be described later. In order to form fine droplets through discontinuous injection of water, it is advantageous that the diameter of the bubble water circulation pipe 400 satisfies the above range.

In one embodiment of the present invention, before the raw water is sprayed through the spray nozzle 200, a step of filtering the raw water to remove micro bubbles of 50 μm or more included in the raw water may be further included.

Specifically, by further performing the filtering step of the raw water, it is possible to secure a defect space between water molecules by removing micro bubbles of 50 μm or more included in the raw water, so the object of the nitric oxide nanobubbles included in the nitric oxide nanobubble water The number can be maximized, and nitric oxide nanobubble water containing the number of nanobubbles in the desired range can be produced, and only raw material water from which bubbles of 50 μm or larger are removed in advance is sprayed to produce nitric oxide nanobubble water. It has the advantage of being able to prepare nitric oxide nanobubble water containing nitric oxide nanobubbles of a uniform and finer size.

In one embodiment, micro-bubbles of 50 μm or more included in the raw water may be removed by a filter (not shown) including fine pores.

The size of the micropores included in the filter may be 50 μm or less, preferably 10 μm or less, more preferably 1 μm or less, and more preferably 500 nm or less, and the lower limit may be 50 nm or more, but the lower limit is not limited. .

For example, the filter may be provided between the pressure pump 500 and the injection nozzle 200 in the circulation pipe 400, and a single and/or a plurality of filters may be provided in the circulation pipe 400. am.

In the method for producing high-concentration nitric oxide nanobubble water according to one aspect of the present invention, nitrogen oxide gas is supplied into the bubble water production tank 100 to contact the sprayed fine droplets, and the droplets in contact with the nitrogen oxide gas are formed on the uneven surface. Conflicting steps may be further included.

In one embodiment, the nitrogen oxide gas may be supplied through the gas inlet pipe 300 so that the pressure inside the bubble water production tank 100 is 0.1 to 4 bar, preferably 0.1 to 2 bar.

For example, the supplied nitrogen oxide gas may be supplied heated to a temperature of 20 to 200 ° C, specifically heated to a temperature of 50 to 100 ° C, and more specifically heated to a temperature of 60 to 80 ° C and can be supplied.

The heated and supplied nitrogen oxide gas expands the distance between gas molecules and flows into the bubble water production tank 100, and then contacts the sprayed fine droplets and then dissolves. It is possible to further refine the size.

For example, the size of nitrogen oxide bubbles can be adjusted according to the heating temperature of the supplied nitrogen oxide gas, and the bubbles having a finer size can be used for cleaning semiconductor circuits that are gradually becoming finer.

In one embodiment of the present invention, liquid droplets in contact with the supplied nitrogen oxide gas may collide with the concave-convex surface in the bubble water production tank 100 .

At this time, the concavo-convex surface may be a surface including a plurality of concave-convex mountains on one wall of the bubble water production tank 100.

The liquid droplets injected at high pressure toward the concave-convex surface come into contact with the supplied nitrogen oxide gas and collide with the concave-convex surface to further refine them. As the surface area of the finer droplets increases, the contact with the nitrogen oxide gas supplied into the bubble water production tank 100 increases, so that high-concentration nitrogen oxide nanobubble water can be produced. In addition, the droplet in contact with the nitrogen oxide gas can flow in the direction of gravity along the uneven surface after colliding with the uneven surface, and the nitrogen oxide gas is further adsorbed on the surface of the droplet due to additional contact with the nitrogen oxide gas supplied during the flow. The number of nitrogen oxide bubbles is increased compared to the initial raw material water by mixing the liquid droplets with a large amount of nitrogen oxide gas adsorbed with raw water that is not sprayed through the injection nozzle 200 present in the bubble water production tank 100. Nitric oxide bubble water can be formed.

In one specific example, the bottom surface of the uneven mountain, that is, the bottom surface facing the vertex of the uneven mountain may be located in contact with one side of the bubble water production tank 100.

For example, the angle between the reference line passing through the center point of the bottom surface at the vertex of the uneven mountain and the side line of the bubble water production tank 100 in the gravity direction may be 1 to 90 degrees, specifically 30 to 90 degrees. And, more specifically, it may be 45 to 90 degrees.

When a droplet in contact with nitrogen oxide gas flows in the gravitational direction along the uneven surface after colliding with the uneven surface, the angle between the above-described reference line and one side line satisfies the above range, so that the residence time of the liquid droplet is increased and applied to the surface of the liquid droplet. Since nitrogen oxide gas can be further adsorbed, it can be advantageous for the production of high-concentration nitric oxide nanobubble water.

In one embodiment, one side of the bubble water production tank 100 may include a plurality of first concave-convex mountains 110 having the shape of the aforementioned concave-convex surface.

As an embodiment, the bubble water production tank 100 may further include a bubble crusher 120 at the center of the bottom, and at this time, the bubble crusher 120 has a plurality of second uneven mountains 121 on its outer surface. Of course, the second concave-convex acid 121 may also be located on the outer surface of the bubble crusher 120 in the form of the concave-convex acid described above.

FIG. 4 is a view showing an embodiment in which a bubble crusher 120 including a plurality of second uneven mountains 121 is further provided in the bubble water production tank 100.

As described above, the raw water containing nitrogen oxide microbubbles is injected in the form of fine droplets from the injection nozzle 200, and the droplets colliding with the uneven surface are further refined to increase the surface area, and the supplied nitrogen oxide gas and It is possible to increase the number of nitric oxide nanobubbles by contact with the sprayed raw material by further providing a bubble crusher 120 including a plurality of second concave-convex mountains 121 at the center of the bottom of the bubble water production tank 100. Not only does the water induce a collision with the first uneven mountain 110 formed on one wall of the bubble water production tank 100, but also the raw material water sprayed from the center of the spray nozzle 200 and the second uneven mountain 121 Collision can also be induced, so the effect can be maximized.

The inside of the bubble water production tank 100 including the concave-convex surface may be surface-treated.

In one embodiment, an inner wall surface of the bubble water production tank 100 including a concave-convex surface may be surface-modified to be hydrophobic.

Here, the inner wall surface may include a side surface, a bottom surface, and/or an upper surface inside the bubble water production tank 100 .

For example, surface modification with hydrophobicity is satisfied as long as the surface of the metal can have hydrophobicity, so it goes without saying that a metal surface treatment method for improving hydrophobicity known in the art can be applied. For example, the inner wall of the bubble water production tank 100 may be coated with a hydrophobic polymer material such as Teflon (-C ₂ F ₄ -), but the present invention is not limited thereto.

The nitrogen oxide bubbles generated on the inner wall surface of the hydrophobic surface-modified bubble water production tank 100 can maintain a stable state due to the repulsive force of the surface charge.

As another specific example, the inner wall surface of the bubble water production tank 100 including the concave-convex surface may be surface-modified with negative charges.

Nitric oxide bubbles exhibit a negative surface charge, and the bubbles can be stabilized by the repulsive force between the bubbles. ) in which nitrogen oxide bubbles can maintain a stable state.

For example, the surface modification may be that a self-assembled monolayer (SAM) is formed on the inner wall surface of the bubble water production tank 100.

The self-assembled monolayer may be formed by performing methods such as physical vapor deposition, sputtering, electroplating, and wet precipitation, but is not limited thereto.

For example, the self-assembled monolayer may include a negatively charged functional group at an end, and the negatively charged functional group is selected from a carboxyl group (-COOH), a phosphoric acid group (-PO ₃ H ₂ ), a sulfonic acid group (-SO ₃ H), and mixtures thereof. It may be one or more.

According to an embodiment of the present invention, the raw water containing nitrogen oxide microbubbles is sprayed toward the uneven surface in the form of fine droplets by the spray nozzle 200 and the sprayed fine droplets and the bubble water production tank 100 It is possible to control the physical properties of the nitric oxide nanobubble water by repeatedly performing a step in which the droplet contacted with the nitrogen oxide gas is brought into contact with the nitrogen oxide gas and collided with the uneven surface.

Here, the physical properties of the nitric oxide nanobubble water may be one or more selected from the size and concentration of nitrogen oxide bubbles included in the nitric oxide nanobubble water, and the number of nitric oxide nanobubbles can be determined by the number of repetitions of the above steps. properties can be controlled. In this case, the concentration of nitric oxide bubbles may mean the number of nitric oxide nanobubbles included per 1ml of the number of nitric oxide nanobubbles.

Depending on the number of repetitions of the above steps, the average particle diameter of the nitric oxide nanobubbles included in the high-concentration nitric oxide nanobubble water can be adjusted. It is preferable that the average particle diameter of the nanobubbles is 200 nm or less, preferably 150 nm or less, more preferably 120 nm or less, and even more preferably 100 nm or less. The lower limit of the average particle diameter of the nitric oxide nanobubbles included in the number of bubbles is not limited.

For example, the number of nitric oxide nanobubbles included in the nitric oxide nanobubble number may be 10 ⁵ to 10 ¹⁰ , specifically 10 ⁶ to 2 x 10 ⁹ per 1 ml of the nitric oxide nanobubble number. And, more specifically, it may be 10 ⁸ to 10 ⁹ , and more specifically, 2 x 10 ⁸ to 8 x 10 ⁸ .

In this case, the number of nitric oxide nanobubbles may be a value measured by nanoparticle tracking analysis (NTA).

In order to have the physical properties of the above-described nitric oxide nanobubble water, the above-described steps are repeated 1 to 100 times, specifically 1 to 50 times, more specifically 1 to 20 times, and more specifically 1 to 10 times. However, the present invention is not limited thereto.

In addition, as described above, the size of the nitrogen oxide bubbles can be controlled by adjusting the heating degree, that is, the temperature, of the nitrogen oxide gas supplied according to the use, and the number of bubbles of a desired size and range can be obtained through the filtering step. Therefore, it goes without saying that the physical properties of the nitric oxide nanobubble water can be controlled not only by the number of repetitions of the above steps, but also by the heating temperature of the supplied nitrogen oxide gas and the filtering step. It is not limited to nitrogen oxide gas that the size and number of bubbles included in the bubble water are adjusted according to the filtering step and the degree of heating of the gas.

As an embodiment of the present invention, after repeating the above steps, a step of stabilizing the nitric oxide bubbles included in the nitric oxide nanobubble water may be further included.

In one embodiment, stabilization of the nitric oxide bubble may be accomplished by supplying a bubble stabilizer.

In detail, the long-term viability of nitric oxide bubbles is affected by the surface charge of the bubbles. At this time, the nitric oxide bubbles exhibit a negative surface charge and generate a repulsive force between the bubbles to stabilize the bubbles, but by supplying a bubble stabilizer The surface of the nitric oxide bubble having a negative surface charge is surrounded by the bubble stabilizer, so that the nitric oxide bubble can be further stabilized. In addition, existing nitric oxide bubbles stably exist due to the repulsive force between the bubbles having a negative surface charge, whereas the number of bubbles that can exist in a limited space may be limited due to the electrostatic repulsive force between the bubbles, but as a bubble stabilizer The enclosed nitric oxide bubbles have the advantage of having an increased number of bubbles in a limited space by reducing the distance between bubbles that can exist than before due to the effect of reducing surface charge.

In one embodiment, the bubble stabilizer supplied for stabilization of nitric oxide bubbles is not limited, but any bubble stabilizer that is harmless to the human body and capable of reducing the surface charge of nitric oxide bubbles is sufficient.

For example, the foam stabilizer may be one or more selected from metal ions, vitamins, cationic polymers, and mixtures thereof.

In one embodiment, the metal ion may be one or more selected from sodium ion, potassium ion, magnesium ion, calcium ion, zinc ion, and mixtures thereof, and the vitamin may be vitamin C, vitamin E, beta-carotene, catechin, quercetin, and It may be one or more selected from mixtures thereof, but the present invention is not limited thereto.

In addition, the cationic polymer may be one or more selected from chitosan, alginic acid, poly(lactic-co-glycolic acid), gelatin, polylysine, polyethyleneimine, and mixtures thereof, but an example of the cationic polymer may be obtained from nature. Of course, it may also contain natural substances.

According to one embodiment of the present invention, the concentration of nitrogen oxide bubbles can be maintained at 60% or more even after heating high-concentration nitric oxide nanobubble water for 10 minutes.

In one embodiment, the heating temperature of the high-concentration nitric oxide nanobubble water may be 30 to 90 °C, specifically 40 to 90 °C, and more specifically 60 to 80 °C.

In one embodiment, even after heating the high-concentration nitric oxide nanobubble water for 10 minutes in the above temperature range, the concentration of nitrogen oxide bubbles included in the high-concentration nitric oxide nanobubble water can be maintained at 55% or more, preferably 60% It can be maintained more than 70% more preferably, more preferably more than 80%.

As described above, the nitric oxide nanobubble water prepared according to the method for producing high-concentration nitric oxide nanobubble water of the present invention has the advantage of stably maintaining the concentration of nitric oxide nanobubbles for a long time without an additional process using a conventional cooling device. have

According to another aspect, the present invention contains a bubble stabilizer, has an average particle diameter of 200 nm or less, and contains 10 ⁵ to 2 X 10 ⁹ nitric oxide nanobubbles per 1ml of nitric oxide nanobubbles at high concentration of nitric oxide nanobubbles. Gives the number of bubbles.

The high-concentration nitric oxide nanobubble water of the present invention has an average particle diameter of 200 nm or less and contains a bubble stabilizer, even though it contains a high concentration of nitric oxide nanobubbles, so that a separate cooling process or refrigeration device is required unlike the prior art. It may have the advantage of being able to be stored for a long time without the provision of. Here, the long term may mean 6 months or more, preferably 8 months or more, more preferably 12 months or more, and even more preferably 16 months or more under conditions of 20 ° C. and 1 atm.

In one embodiment, the average particle diameter of the nitric oxide nanobubbles may be 200 nm or less, specifically 150 nm or less, more specifically 120 nm or less, and even more specifically 100 nm or less, and for example, the average particle diameter of the nitric oxide nanobubbles may be 50 nm or more However, the lower limit of the average particle diameter of the nitric oxide nanobubbles included in the nitric oxide number is not limited.

For example, the number of nitric oxide nanobubbles included in the nitric oxide nanobubble number may be 10 ⁵ to 10 ¹⁰ per 1 ml of the nitric oxide nanobubble number, specifically 10 ⁶ to 2 x 10 ⁹ And, more specifically, it may be 10 ⁸ to 10 ⁹ , and more specifically, 2 x 10 ⁸ to 8 x 10 ⁸ .

In one embodiment, the foam stabilizer may be at least one selected from metal ions, vitamins, cationic polymers, and mixtures thereof. For example, the metal ions include sodium ions, potassium ions, magnesium ions, calcium ions, and zinc. It may be at least one selected from ions and mixtures thereof, the vitamin may be at least one selected from vitamin C, vitamin E, beta-carotene, catechin, quercetin, and mixtures thereof, and the cationic polymer may be chitosan, alginic acid, poly (lactic-co-glycolic acid), gelatin, polylysine, polyethyleneimine, and mixtures thereof, but the present invention is not limited thereto.

When the high-concentration nitric oxide nanobubble water further containing the above-mentioned bubble stabilizer is used for biomedical purposes, the nitric oxide nanobubbles are stably maintained for a long period of time, which is advantageous for storage, and not only the functional role of nitric oxide in the human body, but also the human body. Since the effect of the foam stabilizer can also be expected in the biomedical use, it may be desirable.

In one embodiment of the present invention, the concentration of nitrogen oxide bubbles contained in the high-concentration nitric oxide nanobubble water can be maintained at 60% or more even after heating the high-concentration nitric oxide nanobubble water for 10 minutes.

In one embodiment, the high-concentration nitric oxide nanobubble number may be 30 to 90 ° C, specifically 40 to 90 ° C, and more specifically, heated to a temperature of 60 to 80 ° C, in the above-mentioned temperature range Even after heating the high-concentration nitric oxide nanobubble water for 10 minutes, the concentration of nitrogen oxide bubbles contained in the high-concentration nitric oxide nanobubble water can be maintained at 55% or more, preferably at 60% or more, and more preferably at 70% or more. % or more, and even better, more than 80%.

This is possible because nitrogen oxide bubbles having an average particle diameter within the aforementioned range are micronized to a uniform size and included in the nitrogen oxide nanobubble water containing a bubble stabilizer.

Although the embodiments of the present invention have been described with reference to the accompanying drawings, those skilled in the art can implement them in other specific forms without changing the technical spirit or essential features of the present invention. you will be able to understand Accordingly, the embodiments described above are illustrative in all respects and are not restrictive.

(Example 1)

After filling the bubble water production tank 100 with 200 liters of distilled water, nitrogen oxide gas is passed through the gas inlet pipe 300 until the internal pressure of the bubble water production tank 100 reaches 1 bar. Inside the bubble water production tank 100 supplied with Thereafter, raw water was prepared by reducing the internal pressure to 0.5 bar using a vacuum pump (600).

The produced raw water is supplied to the injection nozzle 200 using a 2-horsepower pressure pump 500 to pass through the injection nozzle 200, and at this time, nitrogen oxide gas is supplied into the bubble water production tank 100 again. Thus, nitric oxide bubble water containing nitric oxide nanobubbles was prepared.

Thereafter, the primarily prepared nitric oxide water was recirculated at a pressure of 50 bar using a pressure pump 500, and after repeating this process three times, it was confirmed that the average particle diameter of the formed nitric oxide nanobubbles was 180 nm. , the number of nitric oxide nanobubbles formed was measured as 2 X 10 ⁸ /mL. At this time, the size and number of nanobubbles were confirmed through nanoparticle tracking analysis (NanoSight NS300).

(Example 2)

It was carried out in the same manner as in Example 1, except that oxygen in the distilled water was removed using hydrogen gas before raw water was prepared, and then hydrogen gas was removed again by vacuum degassing.

At this time, the average particle diameter of the confirmed nitric oxide nanobubbles was 120 nm, and the number of nitric oxide nanobubbles was confirmed to be 3 X 10 ⁸ /mL.

(Example 3)

It was carried out in the same manner as in Example 1, but 0.5 g of chitosan was added to the prepared nitrogen oxide bubble water.

At this time, the average particle diameter of the confirmed nitric oxide nanobubbles was 100 nm, and the number of nitric oxide nanobubbles was confirmed to be 5 X 10 ⁸ /mL.

(Example 4)

It was carried out in the same manner as in Example 1, but when the raw water passed through the injection nozzle 200, nitrogen oxide gas was heated to a temperature of 70 ° C and supplied.

At this time, the average particle diameter of the confirmed nitric oxide nanobubbles was 50 nm, and the number of nitric oxide nanobubbles was confirmed to be 4 X 10 ⁸ /mL.

(Example 5)

Nitric oxide bubble water was prepared in the same manner as in Example 1, except that a filter containing 400 nm pores was installed between the pressure pump 500 and the spray nozzle 200.

At this time, the average particle diameter of the confirmed nitric oxide nanobubbles was 70 nm, the number of nitric oxide nanobubbles was 7 X 10 ⁸ /mL, and bubbles of 400 nm or more were hardly observed.

(Example 6)

It was carried out in the same manner as in Example 2, but 0.5 g of chitosan was added to the prepared nitrogen oxide bubble water.

At this time, the average particle diameter of the confirmed nitric oxide nanobubbles was 60 nm, and the number of nitric oxide nanobubbles was confirmed to be 8 X 10 ⁸ /mL.

(Experimental Example 1)

After heating the number of nitric oxide bubbles of Examples 1 to 6 at 70 ° C. for 10 minutes, the number of nitric oxide nanobubbles and the change in average diameter of the nitric oxide nanobubbles were measured, and the results are summarized in Table 1. did

Number of nitric oxide nanobubbles Early After heating (70℃, 10 minutes) Example 1 2 X 10 ⁸ units/mL 1.31 X 10 ⁸ units/mL Example 2 3 X 10 ⁸ units/mL 1.95 X 10 ⁸ units/mL Example 3 5 X 10 ⁸ units/mL 3.81 X 10 ⁸ units/mL Example 4 4 X 10 ⁸ units/mL 3.01 X 10 ⁸ units/mL Example 5 7 X 10 ⁸ units/mL 4.91 X 10 ⁸ units/mL Example 6 8 X 10 ⁸ units/mL 6.56 X 10 ⁸ units/mL

No significant change was observed in the average particle diameter of the nitric oxide nanobubbles even after heating at 70° C. for 10 minutes.

100: bubble water production tank
110: first uneven mountain
120: bubble crusher
121: 2nd uneven mountain
200: injection nozzle
300: gas inlet pipe
400: bubble water circulation pipe
500: pressure pump
600: vacuum pump

Claims (19)

It is a method for producing high-concentration nitric oxide (NO) nanobubble water,
a) spraying raw water containing nitrogen oxide microbubbles in a bubble water production tank in the form of fine droplets in the direction of gravity by a spray nozzle located above the production tank; and
b) supplying nitrogen oxide gas into the production tank to contact the sprayed fine droplets;
Further comprising filtering the raw water so that micro bubbles of 50 μm or more included in the raw water are removed before the raw water is sprayed,
The nitrogen oxide gas supplied into the production tank is heated to a temperature of 20 to 200 ° C and supplied,
The physical properties of at least one nitric oxide nanobubble water selected from the size and concentration of nitrogen oxide bubbles included in the high-concentration nitric oxide nanobubble water are filtered from the raw water and the degree of heating of the supplied nitrogen oxide gas is selected. A method for producing high-concentration nitric oxide nanobubble water controlled by any one or more factors. According to claim 1,
In step a), the raw material water is discontinuously sprayed. According to claim 2,
The discontinuous spraying is a method for producing high-concentration nitric oxide nanobubble water that occurs while the bubbles contained in the raw water are compressed and pass through a spray nozzle containing fine holes. delete delete delete According to claim 1,
The method for producing high-concentration nitric oxide nanobubble water, further comprising the step of removing dissolved gas contained in the water used for preparing the raw water before step a). According to claim 7,
The dissolved gas is a method for producing high-concentration nitric oxide nanobubble water that is removed through a bubbling process of a gas removing agent. According to claim 8,
A method for producing high-concentration nitrogen oxide nanobubble water further performing a vacuum degassing process after performing the bubbling process. According to claim 7,
Steps a) and b) are repeatedly performed to control the physical properties of at least one nitric oxide nanobubble number selected from the size and concentration of nitric oxide bubbles included in the nitric oxide nanobubble number by the number of repetitions Method for producing high-concentration nitric oxide nanobubble water. According to claim 10,
The method of producing high-concentration nitric oxide nanobubble water in which the average particle diameter of the nitrogen oxide bubbles is 200 nm or less. According to claim 10,
After the step b), the step of stabilizing the nitric oxide bubbles; method for producing high-concentration nitric oxide nanobubble water, further comprising. According to claim 12,
The stabilization of the nitric oxide bubbles is a method for producing high-concentration nitric oxide nanobubble water by supplying a bubble stabilizer. According to claim 13,
The foam stabilizer is a method for producing high-concentration nitric oxide nanobubble water, which is at least one selected from metal ions, vitamins, cationic polymers, and mixtures thereof. According to claim 13,
The concentration of the nitrogen oxide bubbles is maintained at 60% or more even after heating the high concentration nitric oxide nanobubble water for 10 minutes. According to claim 1,
The inside of the bubble water production tank may further include a vertex and an uneven surface including a plurality of concave-convex mountains positioned in contact with one side of the bubble water production tank with a bottom surface positioned opposite to the vertex. Manufacturing method of. According to claim 16,
The angle between the reference line passing through the center point of the bottom surface at the vertex of the uneven mountain and the side line of the bubble water production tank in the direction of gravity is 1 to 90 degrees. In high-concentration nitric oxide nanobubble water containing a bubble stabilizer, having an average particle diameter of 200 nm or less, and including 10 ⁶ to 2 X 10 ⁹ nitric oxide nanobubbles per 1ml of nitric oxide nanobubble water,
The high-concentration nitric oxide nanobubble water in which the concentration of nitrogen oxide bubbles contained in the high-concentration nitric oxide nanobubble water is maintained at 60% or more even after heating the high-concentration nitric oxide nanobubble water for 10 minutes. delete

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