KR102646479B1 - Composition for solubilization of salicylic acid - Google Patents

Abstract

According to an embodiment of the present application, there is provided a salicylic acid solubilizing composition comprising salicylic acid, a solubilizing agent and a polyol. The solubilizing agent may include Octyldodeceth-16 and C12-14 Pareth-12, and the polyol may be included in an amount of 20 to 90 wt% based on the total weight of the composition.

Description

Salicylic acid solubilizing composition {COMPOSITION FOR SOLUBILIZATION OF SALICYLIC ACID}

This application relates to salicylic acid solubilizing compositions.

Keratinocytes produced in the basal layer of the skin move to the spinous layer, granular layer, and stratum corneum in that order as new keratinocytes are created. The lifespan of keratinocytes is about 2 weeks, and dead keratinocytes remain in the stratum corneum for about 2 weeks before being shed from the skin. Accordingly, the skin regeneration cycle is known to be approximately 28 days.

However, the skin regeneration cycle can become longer or shorter depending on various reasons such as exposure to ultraviolet rays, stress, lack of sleep, lack of moisture, and nutritional imbalance. In particular, when the skin regeneration cycle is prolonged, the stratum corneum thickens, causing the skin to become rough, the absorption and applicability of cosmetics decreases, and dead keratinocytes clog pores, causing acne.

Meanwhile, salicylic acid removes dead skin cells and wastes on the skin surface and in pores, improves acne and soothes the skin through anti-inflammatory and antibacterial effects, so it is used as a main ingredient in exfoliants. However, salicylic acid is a representative poorly soluble ingredient that is oil-soluble, and surfactants and solubilizers to stabilize it are still being studied.

In particular, when the content of salicylic acid is not sufficient, there is a problem of low effects such as improving dead skin cells and improving acne. Accordingly, an effective solubilizer that solubilizes a sufficient content of salicylic acid is needed.

The purpose of this application is to provide a salicylic acid solubilizing composition to solve the above problems.

The technical problems of the present application are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly understood by those skilled in the art from the description below.

In accordance with an embodiment of the present application, a salicylic acid solubilizing composition is provided. The salicylic acid solubilizing composition includes salicylic acid, a solubilizing agent, and a polyol. The solubilizing agent includes octyldodeceth-16 and C12-14pares-12, and the polyol includes 20 to 90% by weight based on the total weight of the composition. You can.

Additionally, the salicylic acid may be included in an amount of 1 to 6% by weight based on the total weight of the composition.

Additionally, the C12-14 pares-12 may be included in a weight ratio of 0.1 to 10 based on the weight of octyldodeceth-16.

In addition, the octyldodeceth-16 may be included in an amount of more than 0.5% by weight and less than 1.5% by weight based on the total weight of the composition.

Additionally, C12-14Pares-12 may be included in an amount of 0.01 to 10% by weight based on the total weight of the composition.

In addition, the polyol is propylene glycol, dipropylene glycol, methylpropanediol, butylene glycol, pentylene glycol, isopentyldiol, hexylene glycol, caprylyl glycol, glycerin, and It may contain one or more types selected from the group consisting of diglycerin.

Additionally, the solubilizer and the polyol may be included in a weight ratio of 1 to 10:20 to 90.

Additionally, the octyldodeceth-16, C12-14pares-12, and polyol may be included in a weight ratio of 1:0.1 to 10:20 to 90.

Additionally, according to an embodiment of the present application, a cosmetic composition may be provided. The cosmetic composition may include a salicylic acid solubilizing composition according to an example of the present application.

Additionally, the cosmetic composition may be used for exfoliation.

According to an example of the present application, a formulation containing salicylic acid, a poorly soluble ingredient, can be stably maintained by adjusting the weight ratio of the solubilizer and polyol.

In addition, according to the embodiment of the present application, the effect of improving keratin can be maximized by stabilizing salicylic acid.

In order to more fully understand the drawings cited in the detailed description of this application, a brief description of each drawing is provided.
Figures 1 to 4 are photographs of the appearance of the salicylic acid solubilizing composition.

The structural or functional descriptions of the embodiments disclosed in this specification are merely illustrative for the purpose of explaining the embodiments according to the technical spirit of the present application. Additionally, embodiments according to the technical idea of the present application may be implemented in various forms other than the embodiments disclosed in this specification. Additionally, the technical idea of the present application is not to be construed as being limited to the embodiments described in this specification.

Among the physical properties mentioned in this specification, in cases where the measurement temperature affects the physical properties, unless otherwise specified, the physical properties are those measured at room temperature and pressure.

Room temperature, the term used herein, is a natural temperature that is not heated or cooled, for example, any temperature in the range of 10 ℃ to 30 ℃, for example, about 15 ℃ or higher, about 18 ℃ or higher, It may mean a temperature of about 20°C or higher, about 23°C or higher, about 27°C or lower, or 25°C. Unless specifically specified in this specification, the unit of temperature is Celsius (°C).

The terms a to b used in this specification include a and b and mean within the range between a and b.

The terms used herein are used to describe embodiments and are not intended to limit and/or limit the application. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, terms such as include or have are intended to designate the presence of features, numbers, steps, operations, components, parts, or combinations thereof described in the specification, but are intended to indicate the presence of one or more other features, numbers, or steps. , it should be understood that this does not exclude in advance the possibility of the presence or addition of operations, components, parts, or combinations thereof.

In this specification, “solubilization” refers to the phenomenon of maintaining a thermodynamically stable state by increasing the solubility of salicylic acid, a poorly soluble component.

In this specification, “solubilizer” refers to a component that increases the solubility of salicylic acid, a poorly soluble component.

In accordance with an embodiment of the present application, a salicylic acid solubilizing composition is provided. The salicylic acid solubilizing composition may include salicylic acid, a solubilizing agent, and a polyol.

Salicylic acid is a fat-soluble BHA (β-Hydroxyacid) ingredient that has effects such as improving dead skin cells and improving acne. However, salicylic acid is an acidic ingredient, and if it contains excessive amounts, skin tissue may be destroyed due to strong irritation.

Salicylic acid is present in an amount of 1% by weight, 1.5% by weight, or 2% by weight, or 6% by weight, 5% by weight, 4% by weight, 3% by weight, 2.5% by weight, or 2% by weight, based on the total weight of the composition. It may be less than %. For example, the salicylic acid solubilization composition may include 1 to 6 weight percent or 2 to 6 weight percent salicylic acid.

If the salicylic acid solubilizing composition contains salicylic acid within the above-mentioned range, salicylic acid can be stably solubilized in the solubilizing composition, and not only can it sufficiently exert effects such as improving keratin and acne even in a cosmetic composition containing the salicylic acid solubilizing composition, It has the advantage of lower risk of skin irritation.

The solubilizing agent is used to stabilize or solubilize salicylic acid, a poorly soluble component, and may include Octyldodeceth-16 and C12-14Pareth-12. The salicylic acid solubilizing composition may, for example, contain 1 to 6% by weight of salicylic acid and therefore require sufficient solubilizing agent and polyol. If the content of the solubilizer and polyol is insufficient, it may be difficult to stabilize or solubilize a high content of salicylic acid, and skin irritation may occur as salicylic acid is not stabilized in the composition.

In examples, octyldodeceth-16 is greater than 0.5% by weight, greater than 0.6% by weight, greater than 0.7% by weight, greater than 0.8% by weight, greater than 0.9% by weight, or greater than 1% by weight, or less than 1.5% by weight, based on the total weight of the composition. , may be included in 1.4 wt% or less, 1.3 wt% or less, 1.2 wt% or less, 1.1 wt% or less, or 1 wt% or less. For example, the salicylic acid solubilization composition may include greater than 0.5 and less than 1.5 weight percent of octyldodeceth-16, 0.6 to 1.4 weight percent, or 0.8 to 1.2 weight percent.

In examples, C12-14Pares-12 is present in an amount of 0.01% by weight or more, 0.05% by weight or more, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 2% by weight or more, 3% by weight or more. or more than 4% by weight, less than 10% by weight, less than 9% by weight, less than 8% by weight, less than 7% by weight, less than 6% by weight, less than 5% by weight, less than 4% by weight, less than 3% by weight, or less than 2% by weight. can be included. For example, the salicylic acid solubilization composition may include 0.01 to 10% by weight or 0.1 to 4% by weight of C12-14pares-12.

In an embodiment, C12-14pares-12 is at least 0.1 weight ratio, at least 0.5 weight ratio, at least 1 weight ratio, at least 2 weight ratio, at least 3 weight ratio, or at least 4 weight ratio, or less than 10 weight ratio, or at least 9 weight ratio, relative to the weight of octyldodeceth-16. Hereinafter, it may be included in an 8 weight ratio or less, a 7 weight ratio or less, a 6 weight ratio or less, a 5 weight ratio or less, a 4 weight ratio or less, a 3 weight ratio or less, or a 2 weight ratio or less. For example, the solubilizer may include C12-14pares-12 in an amount of 0.1 to 10, 0.1 to 8, or 0.1 to 4, based on the weight of octyldodeceth-16.

Polyol refers to an aliphatic compound having two or more hydroxy groups (-OH). In an embodiment, the polyol is Propylene Glycol, Dipropylene Glycol, Methylpropanediol, Butylene Glycol, Pentylene Glycol. , Isopentyldiol, Hexylene Glycol, Caprylyl Glycol, Glycerin, and Diglycerin. can do.

In embodiments, the polyol is present in an amount of 20% or more, 25% or more, 30% or more, or 35% or more, or 90% or less, 80% or less, 70% or less, 60% by weight or less, based on the total weight of the composition. , may be included in 50% by weight or less, 45% by weight or less, 40% by weight or less, 35% by weight or less, or 30% by weight or less. For example, the salicylic acid solubilization composition may include 20 to 90 weight percent, 20 to 60 weight percent, or 20 to 35 weight percent polyol.

In an example, the polyol is 20 parts by weight or more, 25 parts by weight, 30 parts by weight, or 35 parts by weight or less, or 90 parts by weight or less, 80 parts by weight, 70 parts by weight or less, 60 parts by weight or less, based on 1 to 10 parts by weight of the solubilizer. It may be included in 50 parts by weight or less, 45 parts by weight or less, 40 parts by weight or less, 35 parts by weight or less, or 30 parts by weight or less. For example, the polyol may be included in an amount of 20 to 90 parts by weight, 20 to 60 parts by weight, 20 to 45 parts by weight, or 20 to 35 parts by weight, based on 1 to 10 parts by weight of the solubilizer.

In an embodiment, the salicylic acid solubilization composition may include octyldodeceth-16, C12-14pareth-12, and polyol in a weight ratio of 1:0.1 to 10:20 to 90, respectively. Specifically, the salicylic acid solubilization composition contains octyldodeceth-16, C12-14pares-12, and polyol at a weight ratio of 1:0.1 to 10:20 to 60, a weight ratio of 1:0.1 to 10:20 to 45, or 1:0.1 to 1:0.1. It may be included in a weight ratio of 10:20 to 35.

Meanwhile, a capryloyl salicylic acid solubilizing composition was prepared using a solubilizer and polyol in the same manner as in the examples of the present application, but when capryloyl salicylic acid was included, the composition became cloudy and layer separation occurred. Not only was there a problem with the formulation being unstable, but the keratin improvement effect was also lower than that of salicylic acid. That is, the solubilizer and polyol according to the examples of the present application were suitable for solubilizing salicylic acid, but were not suitable for solubilizing capryloylsalicylic acid.

According to an embodiment of the present application, a cosmetic composition containing a salicylic acid solubilizing composition is provided. Cosmetic compositions can be manufactured into various products. For example, it can be manufactured into functional cosmetics such as nutritional cream, essence, and ampoule, or basic cosmetics such as lotion and lotion. In addition, it can be manufactured into soap, detergent, cleansing cream, cleansing water, etc., or into color cosmetics such as lipstick, lip balm, mascara, blusher, shading, highlighter, makeup base, foundation, pact, concealer, skin cover, etc. . It can also be manufactured into hair cleaning products such as shampoo, rinse, hair conditioner, hair gel, etc. Additionally, for example, it may be manufactured as a product that is attached to the skin, such as a pack, hydrogel slimming patch, etc., or may be manufactured as a product that is sprayed on the skin, such as a mist or aerosol.

In an embodiment, the cosmetic composition may further include additives commonly used in the art, within a range that does not impair the effect of the present application. For example, cosmetic compositions include thickeners, pH adjusters, surfactants, stabilizers, preservatives, preservatives, disinfectants, moisturizers, sunscreens, skin conditioning agents, whitening agents, colorants, organic pigments, inorganic pigments, fragrances, vitamins, and natural pigments. , pearl, and other functional ingredients may be further included. Here, the functional ingredients may include, for example, wrinkle improvement ingredients, whitening ingredients, antioxidant ingredients, anti-aging ingredients, plumping ingredients, exfoliating ingredients, scrub ingredients, moisturizing ingredients, skin barrier strengthening ingredients, skin elasticity enhancing ingredients, etc. You can. The mixing amount of the above components can be easily selected by a person skilled in the art within a range that does not impair the purpose and effect of the present application.

In an embodiment, the cosmetic composition may be for exfoliation. Such a cosmetic composition for exfoliation may include commonly used ingredients, specifically, for example, moisturizers, preservatives, thickeners, surfactants, fragrances, etc., in addition to the ingredients mentioned above. Purpose and effect of the present application A person skilled in the art can easily select one as long as it does not damage it.

Hereinafter, the present application will be described in more detail through manufacturing examples and experimental examples. However, these production examples or experimental examples show some experimental methods and compositions to illustratively explain the present application, and the scope of the present application is not limited to these production examples or experimental examples.

Manufacturing example

(1) Preparation example: Preparation of salicylic acid solubilizing composition

Each component was mixed in a weight ratio according to Tables 1 to 4 below and thoroughly stirred to prepare a salicylic acid solubilized composition.

division Manufacturing example 1 Manufacturing example 2 Manufacturing Example 3 Manufacturing example 4 Manufacturing example 5 Comparative Manufacturing Example 1 Comparative Manufacturing Example 2 Comparative Manufacturing Example 3 salicylic acid 2 2 2 2 2 2 2 2 Solubilizer Octyldodeceth-16 One One One One One One - One C12-14Pares-12 0.1 0.5 One 2 3 - 0.1 One polyol Dipropylene glycol 20 20 20 20 20 20 20 15 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100

division Manufacturing example 6 Manufacturing example 7 Manufacturing example 8 Manufacturing example 9 Production example 10 Manufacturing example 11 Comparative Manufacturing Example 4 Comparative Manufacturing Example 5 Comparative Manufacturing Example 6 Comparative Manufacturing Example 7 salicylic acid 2 2 2 2 2 2 2 2 2 2 Solubilizer Octyldodeceth-16 One One One One One One One One 0.5 1.5 C12-14Pares-12 0.1 0.5 One 2 3 4 - 0.05 One One polyol Dipropylene glycol 25 25 25 25 25 25 25 25 25 25 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100

division Manufacturing example 12 Production example 13 Production example 14 Production example 15 salicylic acid 2 2 2 2 Solubilizer Octyldodeceth-16 One One One One C12-14Pares-12 0.1 0.5 One One polyol Dipropylene glycol 30 30 30 35 Purified water to 100 to 100 to 100 to 100

division Comparative Manufacturing Example 8 Comparative Manufacturing Example 9 Capryloylsalicylic acid 2 2 Solubilizer Octyldodeceth-16 One One C12-14Pares-12 0.1 3 polyol Dipropylene glycol 25 25 Purified water to 100 to 100

The specific manufacturing method is as follows.

Salicylic acid or capryloylsalicylic acid was mixed with a solubilizer and stirred, then polyol was added and stirred to prepare a salicylic acid solubilization composition. Afterwards, soluble burns were added to the aqueous phase, stirred sufficiently, and used in the following experiments.

Experiment example

(1) Experimental Example 1: Confirmation of formulation stability of salicylic acid solubilized composition

The formulation stability of the salicylic acid solubilized composition prepared above was confirmed and shown in Tables 5 to 8 below.

Formulation stability was evaluated by leaving the salicylic acid solubilized composition at room temperature (23 ± 2°C) for about 4 weeks, then visually observing changes in its properties, and evaluating whether layer separation or precipitation occurred and the degree of transparency.

division Formulation stability Manufacturing example 1 stability Manufacturing example 2 stability Manufacturing example 3 stability Manufacturing example 4 stability Manufacturing example 5 stability Comparative Manufacturing Example 1 Instability Comparative Manufacturing Example 2 Instability Comparative Manufacturing Example 3 Instability

When containing 20% by weight of polyol, the formulations of Preparation Examples 1 to 5 containing 1% by weight of octyldodeceth-16 and 0.1 to 3% by weight of C12-14pares-12 were maintained stably.

On the other hand, Comparative Preparation Example 1, which did not contain C12-14Pares-12, and Comparative Preparation Example 2, which did not contain Octyldodeceth-16, had unstable formulations due to layer separation and precipitation.

On the other hand, Comparative Preparation Example 3 containing 15% by weight of polyol was cloudy and the formulation was unstable.

As shown in Figure 1, Preparation Examples 1 to 5 showed a transparent appearance, while Comparative Preparation Examples 1 to 3 showed layer separation and precipitation or had a cloudy appearance.

division Formulation stability Manufacturing example 6 stability Manufacturing example 7 stability Manufacturing example 8 stability Manufacturing example 9 stability Production example 10 stability Manufacturing example 11 stability Comparative Manufacturing Example 4 Instability Comparative Manufacturing Example 5 Instability Comparative Manufacturing Example 6 Instability Comparative Manufacturing Example 7 Instability

When containing 25% by weight of polyol, the formulations of Preparation Examples 6 to 11 containing 1% by weight of octyldodeceth-16 and 0.1 to 4% by weight of C12-14pares-12 were maintained stably.

On the other hand, Comparative Preparation Example 4, which did not contain C12-14 Pares-12, had an unstable formulation due to layer separation and precipitation.

On the other hand, Comparative Preparation Example 5 containing 1% by weight of octyldodeceth but 0.05% by weight of C12-14Pares-12 (when the weight ratio of C12-14Pares-12 to the weight of octyldodeceth is outside the range of 0.1 to 10 weight ratio), Comparative Preparation Example 6 containing 0.5% by weight of octyldodeceth and Comparative Preparation Example 7 containing 1.5% by weight of octyldodeceth were cloudy or layer separation was observed, making the formulation unstable.

As shown in Figure 2, Preparation Examples 6 to 11 showed a transparent appearance, while Comparative Preparation Examples 4 to 7 showed layer separation or a cloudy appearance.

division Formulation stability Manufacturing example 12 stability Production example 13 stability Production example 14 stability Production example 15 stability

When containing 30% by weight of polyol, Preparation Examples 12 to 14 containing 1% by weight of octyldodeceth-16 and 0.1 to 1% by weight of C12-14 Pares-12, and when containing 35% by weight of polyol, octyldodeceth In Preparation Example 15, which contained 1% by weight of -16 and 1% by weight of C12-14Pares-12, the formulation was maintained stably.

As shown in Figure 3, Preparation Examples 12 to 15 showed a transparent appearance.

division Formulation stability Comparative Manufacturing Example 8 Instability Comparative Manufacturing Example 9 Instability

Meanwhile, Comparative Preparation Example 8, which contained a solubilizer and a polyol in the same manner as Preparation Example 6, but contained capryloylsalicylic acid instead of salicylic acid, became cloudy and the formulation was unstable, and contained a solubilizer and a polyol in the same manner as Preparation Example 10, but contained capryloylsalicylic acid instead of salicylic acid. Comparative Preparation Example 9 containing capryloyl salicylic acid became cloudy and layer separation occurred, making the formulation unstable.

As shown in Figure 4, in Comparative Preparation Examples 8 and 9, clouding or layer separation was observed.

(2) Experimental Example 2: Confirmation of exfoliation rate of salicylic acid solubilized composition

The exfoliation rate of the salicylic acid solubilized composition prepared above was confirmed and shown in Tables 9 to 12 below.

Fifteen healthy adult men and women with clean forearm areas without pigmentation or acne were selected as the experimental group. After gently washing and drying the forearm area, a 5% DHA (Dihydroxyacetone) solution was applied twice a day for 2 days to tan the skin. The skin color (L value) of the area colored brown by DHA was measured, and the salicylic acid solubilizing composition was applied twice a day for 2 weeks. The exfoliation rate was calculated by applying the skin color (L value) after 2 weeks and the initial skin color (L value) to the following equation.

Exfoliation rate (%) = (L value after 14 days - L value after applying DHA) / (L value before applying DHA - L value after applying DHA) * 100

division Keratin exfoliation rate (%) Manufacturing example 1 21.08 Manufacturing example 2 21.94 Manufacturing example 3 22.11 Manufacturing example 4 22.68 Manufacturing example 5 23.40 Comparative Manufacturing Example 1 18.67 Comparative Manufacturing Example 2 19.85 Comparative Manufacturing Example 3 18.26

When containing 20% by weight of polyol, Preparation Examples 1 to 4 containing 1% by weight of octyldodeceth-16 and 0.1 to 3% by weight of C12-14Pares-12, keratin as the content of C12-14Pares-12 increases. The exfoliation rate increased, and a keratin exfoliation rate of over 20.00% was confirmed. On the other hand, Comparative Preparation Example 1, which did not contain C12-14Pares-12, had a keratin exfoliation rate of only 18.67%.

In addition, the exfoliation rate of Comparative Preparation Example 2, which was manufactured in the same manner as Preparation Example 1 but did not contain octyldodeceth-16, was 19.85%, confirming a significantly lower exfoliation rate than Preparation Example 1.

Meanwhile, in Comparative Preparation Example 3 containing 15% by weight of polyol, the exfoliation rate was only 18.26%, and when the polyol content was less than 20% by weight, the exfoliation rate was found to be reduced.

division Keratin exfoliation rate (%) Manufacturing example 6 20.84 Manufacturing example 7 20.66 Manufacturing example 8 21.29 Manufacturing example 9 22.01 Production example 10 23.59 Manufacturing example 11 25.65 Comparative Manufacturing Example 4 17.49 Comparative Manufacturing Example 5 17.67 Comparative Manufacturing Example 6 18.52 Comparative Manufacturing Example 7 19.68

When containing 25% by weight of polyol, Preparation Examples 6 to 11 containing 1% by weight of octyldodeceth-16 and 0.1 to 4% by weight of C12-14Pares-12, keratin as the content of C12-14Pares-12 increases. The peeling rate showed a tendency to increase.

Comparative Preparation Example 4, which does not contain C12-14 Pares-12, has a keratin exfoliation rate of 17.49%, while Comparative Preparation Example 5, which contains 1 wt% of octyldodeceth but contains 0.05 wt% of C12-14 Pares-12, has a keratin exfoliation rate of 17.49%. The keratin exfoliation rate was only 17.67%, showing a lower keratin improvement effect compared to the case where the weight ratio of C12-14Pares-12 to the weight of octyldodeceth was within 0.1 to 10 weight ratio (Preparation Examples 6 to 11).

Meanwhile, Comparative Preparation Example 6 containing 1% by weight of C12-14Pares-12 but less than 0.5% by weight of octyldodeceth and Comparative Preparation Example 7 containing more than 1.5% by weight of octyldodeceth had exfoliation rates of 18.52, respectively. % and 19.68%, showing a lower keratin improvement effect compared to Preparation Example 8.

division Keratin exfoliation rate (%) Manufacturing example 12 23.62 Production example 13 24.02 Production example 14 24.23 Production example 15 24.88

When containing 30% by weight of polyol, Preparation Examples 12 to 14 containing 1% by weight of Octyldodeceth-16 and 0.1 to 1% by weight of C1214 Pares-12 had exfoliation rates of 23.62%, 24.02%, and 24.88%, respectively. It was found to be over 20.00%.

In addition, when containing 35% by weight of polyol, Preparation Example 15 containing 1% by weight of octyldodeceth-16 and 1% by weight of C12-14pares-12 was confirmed to have an exfoliation rate of 24.88%.

division Keratin exfoliation rate (%) Comparative Manufacturing Example 8 15.67 Comparative Manufacturing Example 9 20.96

Meanwhile, Comparative Preparation Example 8, which contains the same solubilizer and polyol as Preparation Example 6 but includes capryloylsalicylic acid instead of salicylic acid, had a keratin exfoliation rate of 15.67%, showing a lower keratin improvement effect compared to Preparation Example 6 (18.37%). It seemed.

In addition, Comparative Preparation Example 9, which contains the same solubilizer and polyol as Preparation Example 10, but includes capryloylsalicylic acid instead of salicylic acid, had a keratin exfoliation rate of 20.96%, showing a lower keratin improvement effect compared to Preparation Example 10 (23.59%). It seemed.

As the specific parts of the content of the present application have been described in detail above, it is clear to those skilled in the art that these specific descriptions are merely preferred embodiments and do not limit the scope of the present application. It will be obvious. Accordingly, the actual scope of the present application will be defined by the attached claims and their equivalents.

Claims (10)

Contains salicylic acid, solubilizers and polyols,
The solubilizers include octyldodeceth-16 and C12-14pares-12,
The C12-14pares-12 is contained in a weight ratio of 0.1 to 10 based on the weight of octyldodeceth-16,
A salicylic acid solubilizing composition, wherein the polyol is contained in an amount of 20 to 90% by weight based on the total weight of the composition. According to claim 1,
A salicylic acid solubilized composition, wherein the salicylic acid is contained in an amount of 1 to 6% by weight based on the total weight of the composition. delete According to claim 1,
A salicylic acid solubilizing composition, wherein the octyldodeceth-16 is contained in an amount greater than 0.5% by weight and less than 1.5% by weight based on the total weight of the composition. According to claim 1,
A salicylic acid solubilizing composition containing 0.01 to 10% by weight of C12-14Pares-12 based on the total weight of the composition. According to claim 1,
The polyols include propylene glycol, dipropylene glycol, methylpropanediol, butylene glycol, pentylene glycol, isopentyldiol, hexylene glycol, caprylyl glycol, glycerin and diglycerin. A salicylic acid solubilizing composition comprising at least one member selected from the group consisting of. According to claim 1,
A salicylic acid solubilizing composition, wherein the solubilizing agent and the polyol are included in a weight ratio of 1 to 10:20 to 90. According to claim 1,
A salicylic acid solubilizing composition, wherein the octyldodeceth-16, C12-14pareth-12, and polyol are included in a weight ratio of 1:0.1 to 10:20 to 90. A cosmetic composition comprising the salicylic acid solubilizing composition according to any one of claims 1 to 8. According to clause 9,
The cosmetic composition is for removing dead skin cells.