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KR102729973B1 - 인플루엔자 헤마글루티닌에 대한 인간 항체 - Google Patents

인플루엔자 헤마글루티닌에 대한 인간 항체 Download PDF

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KR102729973B1
KR102729973B1 KR1020177020050A KR20177020050A KR102729973B1 KR 102729973 B1 KR102729973 B1 KR 102729973B1 KR 1020177020050 A KR1020177020050 A KR 1020177020050A KR 20177020050 A KR20177020050 A KR 20177020050A KR 102729973 B1 KR102729973 B1 KR 102729973B1
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리사 에이. 퍼셀
조나단 비아우
윌리엄 올슨
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리제너론 파마슈티칼스 인코포레이티드
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Abstract

본 발명은 인플루엔자 헤마글루티닌 (HA) 단백질에 결합하는 단클론성 항체, 또는 이것들의 항원-결합 단편, 항체를 포함하는 약학적 조성물 및 사용 방법을 제공한다. 본 발명의 항체는 인간에서 인플루엔자 바이러스 활성을 억제하거나 중화시키는데 유용하며, 따라서 인간에서 인플루엔자 감염을 치료하거나 예방하는 수단을 제공한다. 일부 구체예에서, 본 발명은 숙주 세포로의 바이러스 부착 및/또는 진입을 방지하기 위해 인플루엔자 HA에 결합하는 하나 이상의 항체의 사용을 제공한다. 본 발명의 항체는 예방적으로 또는 치료적으로 사용될 수도 있고 단독으로 또는 하나 이상의 다른 항바이러스제 또는 백신과 조합하여 사용될 수도 있다.

Description

인플루엔자 헤마글루티닌에 대한 인간 항체{HUMAN ANTIBODIES TO INFLUENZA HEMAGGLUTININ}
본 발명은 인플루엔자 헤마글루티닌 (HA)에 특이적으로 결합하는 인간 항체 및 이것의 항원-결합 단편, 이 항체를 포함하는 조성물 및 이 항체를 사용한 치료 및 진단 방법에 관한 것이다.
서열 목록의 ASCII 호환 텍스트 파일은 본 명세서와 동시에 제출된다 (37 CFR §1.52(e) 및 37 CFR §1.821). 텍스트 파일의 내용물은 본원에 참조로 포함된다. 서열 목록을 포함하는 텍스트 파일은 "10119WO01_seqlisting"으로 명명되었고, 2015년 11월 18일에 생성되었으며, 2.1 MB가 포함되어 있다.
인플루엔자는 매우 전염성이 강한 질환이며, 이것은 범유행(pandemic), 유행(epidemic), 재유행, 및 발병의 추세를 특징으로 하는 오랜 역사를 가지고 있다. 매년의 백신 접종 노력에도 불구하고, 인플루엔자 감염은 상당한 이환율 및 치사율을 초래한다.
인플루엔자 바이러스는 세 가지 유형, A, B 및 C로 구성되어 있다. 또한, 인플루엔자 A 바이러스는 숙주 세포로의 바이러스 부착 및 진입에 필요한 표면 당단백질, 헤마글루티닌 (HA) 및 뉴라미니다제 (NA)를 암호화하는 두 개의 유전자의 항원성 영역의 대립유전자 변이에 따라 서브타입으로 분류될 수 있다.
헤마글루티닌은 두 개의 구조 도메인, 수용체-결합 부위 (빈번한 항원 변이(antigenic drift)의 대상임)로 구성된 구상 머리 도메인 및 줄기 영역 (인플루엔자 바이러스의 다양한 균주들 중에서 더 많이 보존됨)을 함유하는 트리머 당단백질이다. HA 단백질은 전구체 (HA0)로서 합성되며, 이것은 단백질 가수분해 과정을 거쳐, 서로 회합하여 줄기/구상 머리 구조를 형성하는 두 개의 서브유닛 (HA1 및 HA2)을 생산한다. HA1 펩타이드는 세포 표면에 대한 바이러스 부착의 원인이다. HA2 펩타이드는 엔도솜에서 바이러스 및 세포 막의 융합을 매개하여, 세포질로의 리보핵산 단백질 복합체의 방출을 허용하는 줄기-유사 구조를 형성한다.
현재, 헤마글루티닌 단백질에 따라 정의된 18개의 서브타입 (H1-H18)이 존재한다. 18개의 HA는 두 개의 군으로 분류될 수 있다. 1군은 H1, H2, H5, H6, H8, H9, H11, H12, H13, H16, H17 및 H18 서브타입으로 구성되고, 2군은 H3, H4, H7, H10, H14 및 H15 서브타입을 포함한다.
같은 서브타입의 새로운 균주들이 항원 변이라고 불리는 현상, 또는 새롭고 다른 에피토프를 생성하는 HA 또는 NA 분자의 돌연변이의 결과로서 발생할 수도 있다. 이것의 결과는 출현할 것으로 예상되는 바이러스에 대하여 매년 새로운 백신이 생산되어야 한다는 것이며, 비용이 많이 들 뿐 아니라, 매우 비효율적인 과정이다. 기술적 진보가 백신 조성물에 대한 개선된 인플루엔자 항원(들)을 생산하는 능력을 개선하는 한편, 인플루엔자의 신생 서브타입 및 균주들에 대처하기 위한 추가적인 보호원을 제공하는 것이 필요하다.
환자에서 광범위 중화 항체를 생성하기 위해 관심 있는 항원 (예를 들어, HA 및/또는 NA)을 포함하는 백신 조성물의 개념은 일반적으로 양호한 접근법인 것으로 생각되는 한편, 특정 환자 집단에서는 이 접근법을 사용하는 것이 항상 바람직한 것은 아니다. 예를 들어, 어떤 환자에서, 예컨대 노인, 어린이, 면역 손상된 환자 등에서는, 관심 있는 항원을 포함하는 백신 조성물이 항상 효과적인 것은 아닐 수도 있다. 이 환자 집단에서, 또는 효과적인 면역 반응을 일으킬 수 없는 임의의 환자에서, 1군 및/또는 2군 서브타입 내 다양한 균주들에 대하여 공통된 에피토프를 표적화할 수 있는 광범위 중화 항체를 이미 함유하고 있는 조성물을 제공하는 것이 더 유익할 수도 있다.
지금까지 인플루엔자 바이러스를 광범위하게 중화하거나 억제하는 이러한 항체를 확인하는데 있어서 성공이 제한되었다. Okuno 등은 마우스를 인플루엔자 A/Okuda/57 (H2N2)로 면역화하였고 C179로 지칭되는 항체를 분리하였으며, 이것은 시험관 내 및 생체 내에서 HA2의 보존된 입체구조적 에피토프에 결합하여 1군 H2, H1 및 H5 서브타입 인플루엔자 A 바이러스를 중화시켰다 (Okuno et al. (1993) J. Virol. 67(5):2552-2558). Throsby 등은 1군 서브타입에 대하여 광범위한 활성을 가지는 인간 B 세포로부터 13개의 단클론성 항체를 확인하였다 (Throsby et al. (2008), PLOS one 3(2):e3942). Sui 등은 H5 및 다른 1군 바이러스에 결합하는 인간 단클론성 항체 (F10)를 확인하였다 (Sui, et al. (2009), Nat. Struct. Mol. Biol. 16(3):265-273).
하지만, 이 분야에서 수십 년의 연구 끝에, 단지 몇 가지의 항체들은 현재 다른 서브타입의 인플루엔자 바이러스를 중화시키는 능력을 평가하기 위한 임상 시험 중에 있지만 (예를 들어, Crucell Holland ((US2012/0276115, US2014/0065156, US8470327, US2014/0120113, EP2731967, US8691223, US2013/0243792, US2014/0065165, WO2008/028946 및 WO2010/130636); Osaka University (US2011/0319600, EP2380976, US2012/0058124, US2012/0058124), Celltrion (US2013/0004505, EP2545074, WO2014/158001); Vanderbilt University (US2013/0289246), SeaLane Biotechnologies (US2012/0128671), Trellis Bioscience, Inc. (US2012/0020971 EP2582721); Visterra, Inc. (US2013/0302349); Burnham Institute/Dana Farber (US2014/011982, EP2222701, WO2010/027818); Temasek (US8444986, US8574581, US 8637644, US8637645, US8383121, US8540996, US8574830, US8540995); HUMABS Biosciences/Institute for Research in Biomedicine (US8871207); MedImmune (WO2015/051010); 및 Genentech (US2014/0161822)에 의해 개발 중인 항체 참조), 인플루엔자 A 바이러스 감염을 광범위하게 중화시키거나 억제하거나 또는 이 바이러스의 다양한 서브타입에 의해 유발된 질환을 약화시키는 항체는 여전히 판매되고 있지 않다. 따라서, 업계에서는 인플루엔자 바이러스 감염을 예방하거나 치료하는데 사용될 수 있는, 인플루엔자 A 바이러스의 다수의 서브타입을 중화시키는 새로운 항체를 확인하는 것이 여전히 필요하다.
본 발명은 인플루엔자 헤마글루티닌 (HA)에 결합하는 항체 및 그것의 항원-결합 단편을 제공한다. 본 발명의 항체는, 그 중에서도, 인플루엔자 HA의 활성을 억제하거나 중화시키는데 유용하다. 일부 구체예에서, 항체는 숙주 세포에 인플루엔자 바이러스의 부착을 차단하고 및/또는 숙주 세포로의 인플루엔자 바이러스의 진입을 예방하는데 유용하다. 일부 구체예에서, 항체는 바이러스의 세포에서 세포로의(cell-to-cell) 전달을 억제함으로써 기능한다. 특정 구체예에서, 항체는 대상체의 인플루엔자 바이러스 감염의 적어도 하나의 증상을 예방, 치료 또는 경감하는데 유용하다. 특정 구체예에서, 항체는 인플루엔자 바이러스에 감염되거나, 또는 감염될 위험이 있는 대상체에 예방적으로 또는 치료적으로 투여될 수도 있다. 특정 구체예에서, 본 발명의 적어도 하나의 항체를 함유하는 조성물은 백신의 사용이 금지되거나, 또는 백신이 덜 효과적인 대상체, 예를 들어, 고령의 환자, 너무 어린 환자, 백신의 임의의 하나 이상의 성분에 대하여 알레르기 반응이 나타날 수도 있는 환자, 또는 백신의 면역원에 대하여 무반응성일 수도 있는 면역 손상된 환자에게 투여될 수도 있다. 특정 구체예에서, 본 발명의 적어도 하나의 항체를 함유하는 조성물은 의료진, 입원한 환자 또는 양로원 거주자 또는 인플루엔자 발병시 다른 고위험군 환자에게 투여될 수도 있다. 특정 구체예에서, 본 발명의 적어도 하나의 항체를 함유하는 조성물은 매년 예상되는 백신이 비효율적인 경우, 또는 불연속 항원 변이(major antigenic shift)를 가진 균주로의 범유행병인 경우 제1 선 치료로서 환자에게 투여될 수도 있다.
본 발명의 항체는 전장일 수 있거나 (예를 들어, IgG1 또는 IgG4 항체) 항원-결합 부분만을 포함할 수도 있고 (예를 들어, Fab, F(ab')2 또는 scFv 단편), 기능성에 영향을 미치도록, 예를 들어, 숙주에서 지속력을 증가시키거나 또는 효과기 기능을 증가시키거나 잔류 효과기 기능을 제거하도록 변형될 수도 있다 (Reddy et al., 2000, J. Immunol. 164:1925-1933). 특정 구체예에서, 항체는 이중 특이적일 수도 있다.
제1 양태에서, 본 발명은 인플루엔자 HA에 특이적으로 결합하는, 분리된 재조합 단클론성 항체 또는 이것의 항원-결합 단편을 제공한다.
한 구체예에서, 본 발명은 인플루엔자 A 헤마글루티닌 (HA)에 특이적으로 결합하는 분리된 재조합 항체 또는 이것의 항원-결합 단편을 제공하며, 항체는 다음 특징들 중 둘 이상을 가진다:
(a) 완전 인간 단클론성 항체이다;
(b) 실시간 생체막 간섭계 기반 바이오센서(real-time bio-layer interferometer based biosensor)에서 측정된 바와 같이 (Octet HTX 검정), 10-9M 미만의 해리 상수 (KD)로 인플루엔자 HA에 결합한다;
(c) 370분 초과의 해리 반감기 (t½)를 나타낸다;
(d) H1N1, H5N1, H9N2, H13N6 및 H16N3으로부터 선택된 1군 인플루엔자 A 바이러스의 중화를 나타내며, IC50은 130nM 미만이다;
(e) 인플루엔자 바이러스 감염된 세포의 보체 매개 용해를 나타내며, EC50은 66nM 미만이다;
(f) 인플루엔자 바이러스 감염의 동물 모델에서 바이러스 공격접종(virus challenge) 이전 또는 이후 투여될 때 증가된 생존으로 측정된 바와 같이 보호를 나타낸다; 또는
(g) 항체 또는 이것의 항원-결합 단편은 표 1 또는 표 12에서 나열된 중쇄 가변 영역 (HCVR) 서열 중 어느 하나에 함유된 세 개의 중쇄 상보성 결정 영역 (CDR) (HCDR1, HCDR2 및 HCDR3); 및 표 1 또는 표 12에서 나열된 경쇄 가변 영역 (LCVR) 서열 중 어느 하나에 함유된 세 개의 경쇄 CDR (LCDR1, LCDR2 및 LCDR3)을 포함한다.
한 구체예에서, 본 발명의 항체는 원숭이에서 Control I mAb로 지칭되는 비교기 항체보다 약 1.5배 더 큰 해리 반감기 및 마우스에서 Control I mAb보다 약 2배 더 큰 해리 반감기를 나타낸다.
특정 구체예에서, 본 발명의 항체는, 인플루엔자 바이러스로 감염된 포유동물에게 감염 후 48시간, 또는 감염 후 72시간에 투여될 때, 오셀타미비르와 비교하여 보호의 증가를 나타낸다.
관련된 구체예에서, 본 발명의 항체는, 피하로 또는 정맥 내로 투여될 때 및/또는 인플루엔자 바이러스 감염 이전, 또는 감염 이후 투여될 때, 인플루엔자 바이러스로 감염된 포유동물에서 보호의 증가를 부여한다.
한 구체예에서, 본 발명의 항체는, 감염된 포유동물에게 약 0.01 mg/kg 내지 약 50 mg/kg의 범위의 1회 피하 또는 정맥 내 용량으로 투여될 때, 아이소타입 (음성) 대조군 항체가 투여된 동물과 비교하여 보호의 증가를 나타낸다.
한 구체예에서, 본 발명의 항체는 인플루엔자 바이러스 감염된 포유동물에게 약 15 mg/kg의 1회 정맥 내 용량으로 투여될 때 약 5 mg/kg 내지 약 25 mg/kg의 용량으로 5일 동안 1일 2회 투여된 오셀타미비르의 경구 투여와 비교하여 보호의 증가를 나타낸다.
한 구체예에서, 본 발명의 항체는, 약 0.01 mg/kg 내지 약 2 mg/kg의 범위의 1회 피하 용량으로 예방적으로 투여될 때, 인플루엔자 바이러스로 감염된 포유동물에서 약 20% 초과의 생존률을 나타낸다.
한 구체예에서, 본 발명의 항체는, 감염 이후 적어도 24시간까지는 약 7 mg/kg 내지 약 50 mg/kg의 범위의 1회 정맥 내 용량으로 투여될 때, 인플루엔자 바이러스로 감염된 포유동물에서 약 30% 초과의 생존률을 나타낸다.
한 구체예에서, 본 발명의 항체는, 감염 후 48시간에 투여될 때 약 7 mg/kg 내지 약 50 mg/kg의 1회 정맥 내 용량으로 투여될 때, 인플루엔자 바이러스로 감염된 포유동물에서 약 30% 내지 약 60%의 생존률을 나타낸다.
한 구체예에서, 본 발명의 항체는, 감염 후 48시간 또는 그 이후에 약 15 mg/kg 내지 약 30 mg/kg의 1회 정맥 내 용량으로 투여될 때, 인플루엔자 바이러스로 감염된 포유동물에서 약 60% 이상의 생존률을 나타낸다.
한 구체예에서, 본 발명의 항체는, 감염 후 48시간 또는 그 이후에 약 15 mg/kg의 1회 정맥 내 용량으로 투여될 때, 인플루엔자 바이러스로 감염된 포유동물에서 약 100%의 생존률을 나타낸다.
한 구체예에서, 본 발명의 항체는 약 25 mg/kg의 용량으로 5일 동안 1일 2회 경구 투여될 때 오셀타미비르로 관찰된 40% 생존률과 비교하여, 약 15 mg/kg의 1회 정맥 내 용량으로 투여될 때 인플루엔자 바이러스로 감염된 포유동물에서 약 100%의 생존률을 나타낸다.
한 구체예에서, 본 발명의 항체는 감염 후 48시간 이후에 오셀타미비르가 투여될 때 인플루엔자 바이러스로 감염된 포유동물에서 추가적인 보호 효과를 제공한다.
한 구체예에서, 본 발명의 항체는 감염 후 72시간에 오셀타미비르가 투여될 때 인플루엔자 바이러스로 감염된 포유동물에서 추가적인 보호 효과를 제공한다.
한 구체예에서, 본 발명의 항체는 오셀타미비르와 조합하여 사용될 때 추가적인 보호 효과를 제공하며, 항체는 인플루엔자 바이러스 감염된 포유동물에게 약 7 mg/kg 내지 약 15 mg/kg의 범위의 1회 정맥 내 용량으로 투여되고 오셀타미비르는 약 25 mg/kg의 용량으로 5일 동안 1일 2회 경구 투여된다.
관련된 구체예에서, 본 발명의 항체는 인플루엔자 바이러스 감염 후 72시간에 오셀타미비르와 조합하여 사용될 때 추가적인 보호 효과를 제공하며, 항체는 약 7 mg/kg 내지 약 15 mg/kg의 범위의 1회 정맥 내 용량으로 투여되고 오셀타미비르는 약 25 mg/kg의 용량으로 5일 동안 1일 2회 경구 투여된다.
한 구체예에서, 본 발명의 항체는 정맥 내로, 비강 내로, 피하로, 피부 내로, 또는 근육 내로 투여될 수 있고 오셀타미비르는 경구로 투여될 수 있다.
한 구체예에서, 오셀타미비르는 본 발명의 항체의 투여 이전에, 투여와 동시에, 또는 투여 이후에 투여된다.
한 구체예에서, 항체 및/또는 오셀타미비르는 1회 용량으로, 또는 다회수 용량으로 투여될 수도 있다.
본 발명의 전형적인 항-인플루엔자 HA 항체는 본원에서 표 1 및 2에서 나열된다. 표 1은 전형적인 항-인플루엔자 HA 항체의 중쇄 가변 영역 (HCVR), 경쇄 가변 영역 (LCVR), 중쇄 상보성 결정 영역 (HCDR1, HCDR2 및 HCDR3), 및 경쇄 상보성 결정 영역 (LCDR1, LCDR2 및 LCDR3)의 아미노산 서열 식별자를 제시한다. 표 2는 전형적인 항-인플루엔자 HA 항체의 HCVR, LCVR, HCDR1, HCDR2 HCDR3, LCDR1, LCDR2 및 LCDR3의 핵산 서열 식별자를 제시한다.
본 발명의 추가의 전형적인 항-인플루엔자 HA 항체는 본원에서 표 12 및 13에서 나열된다. 표 12는 전형적인 항-인플루엔자 HA 항체의 중쇄 가변 영역 (HCVR), 경쇄 가변 영역 (LCVR), 중쇄 상보성 결정 영역 (HCDR1, HCDR2 및 HCDR3), 및 경쇄 상보성 결정 영역 (LCDR1, LCDR2 및 LCDR3)의 아미노산 서열 식별자를 제시한다. 표 13은 전형적인 항-인플루엔자 HA 항체의 HCVR, LCVR, HCDR1, HCDR2 HCDR3, LCDR1, LCDR2 및 LCDR3의 핵산 서열 식별자를 제시한다.
본 발명은 표 1, 또는 표 12에서 나열된 HCVR 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 HCVR을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
한 구체예에서 본 발명은 인플루엔자 HA에 특이적으로 결합하며, 서열 번호: 2, 18, 34, 50, 74, 90, 106, 122, 138, 154, 170, 186, 202, 218, 234, 242, 250, 258, 266, 274, 282 및 290으로 구성된 군으로부터 선택된 아미노산 서열을 가지는 HCVR을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCVR 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 LCVR을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
한 구체예에서 본 발명은 인플루엔자 HA에 특이적으로 결합하며, 서열 번호: 10, 26, 42, 58, 66, 82, 98, 114, 130, 146, 162, 178, 194, 210 및 226으로 구성된 군으로부터 선택된 아미노산 서열을 가지는 LCVR을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCVR 아미노산 서열 중 어느 것과 쌍을 이룬 표 1, 또는 표 12에서 나열된 HCVR 아미노산 서열 중 어느 것을 포함하는 HCVR 및 LCVR 아미노산 서열 쌍 (HCVR/LCVR)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다. 특정 구체예에 따르면, 본 발명은 표 1, 또는 표 12에서 나열된 전형적인 항-인플루엔자 HA 항체 중 어느 것 내에 함유된 HCVR/LCVR 아미노산 서열 쌍을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
한 구체예에서, 인플루엔자 HA에 특이적으로 결합하는 분리된 항체 또는 항원-결합 단편은 서열 번호: 2/10, 18/26, 34/42, 50/58, 50/66, 74/82, 74/66, 90/98, 106/114, 122/130, 138/146, 154/162, 170/178, 186/194, 202/210, 218/226, 234/66, 242/66, 250/66, 258/66, 266/66, 274/66, 282/66 및 290/66으로 구성된 군으로부터 선택된 HCVR/LCVR 아미노산 서열 쌍을 포함한다.
특정 구체예에서, HCVR/LCVR 아미노산 서열 쌍은 서열 번호: 18/26 (예를 들어, H1H11729P), 50/58 (예를 들어, H1H11829N), 50/66 (예를 들어 H1H11829N2), 또는 106/114 (예를 들어, H1H14571N)로 구성된 군으로부터 선택된다.
한 구체예에서, 분리된 항체 또는 항원-결합 단편은 다음을 포함한다:
(a) 서열 번호: 4, 20, 36, 52, 76, 92, 108, 124, 140, 156, 172, 188, 204, 220, 236, 244, 252, 260, 268, 276, 284, 및 292로 구성된 군으로부터 선택된 아미노산 서열을 가지는 HCDR1 도메인;
(b) 서열 번호: 6, 22, 38, 54, 78, 94, 110, 126, 142, 158, 174, 190, 206, 222, 238, 246, 254, 262, 270, 278, 286, 및 294로 구성된 군으로부터 선택된 아미노산 서열을 가지는 HCDR2 도메인;
(c) 서열 번호: 8, 24, 40, 56, 80, 96, 112, 128, 144, 160, 176, 192, 208, 224, 240, 248, 256, 264, 272, 280, 288, 및 296으로 구성된 군으로부터 선택된 아미노산 서열을 가지는 HCDR3 도메인;
(d) 서열 번호: 12, 28, 44, 60, 68, 84, 100, 116, 132, 148, 164, 180, 196, 212, 및 228로 구성된 군으로부터 선택된 아미노산 서열을 가지는 LCDR1 도메인;
(e) 서열 번호: 14, 30, 46, 62, 70, 86, 102, 118, 134, 150, 166, 182, 198, 214, 및 230으로 구성된 군으로부터 선택된 아미노산 서열을 가지는 LCDR2 도메인; 및
(f) 서열 번호: 16, 32, 48, 64, 72, 88, 104, 120, 136, 152, 168, 184, 200, 216 및 232로 구성된 군으로부터 선택된 아미노산 서열을 가지는 LCDR3 도메인.
한 구체예에서, 인플루엔자 HA에 특이적으로 결합하는 분리된 항체 또는 항원-결합 단편은 (a) 서열 번호: 20의 HCDR1, (b) 서열 번호: 22의 HCDR2; (c) 서열 번호: 24의 HCDR3; (d) 서열 번호: 28의 LCDR1; (e) 서열 번호: 30의 LCDR2 및 (f) 서열 번호: 32의 LCDR3을 포함한다.
한 구체예에서, 인플루엔자 HA에 특이적으로 결합하는 분리된 항체 또는 항원-결합 단편은 (a) 서열 번호: 52의 HCDR1, (b) 서열 번호: 54의 HCDR2; (c) 서열 번호: 56의 HCDR3; (d) 서열 번호: 68의 LCDR1; (e) 서열 번호: 70의 LCDR2 및 (f) 서열 번호: 72의 LCDR3을 포함한다.
한 구체예에서, 인플루엔자 HA에 특이적으로 결합하는 분리된 항체 또는 항원-결합 단편은 (a) 서열 번호: 52의 HCDR1, (b) 서열 번호: 54의 HCDR2; (c) 서열 번호: 56의 HCDR3; (d) 서열 번호: 60의 LCDR1; (e) 서열 번호: 62의 LCDR2 및 (f) 서열 번호: 64의 LCDR3을 포함한다.
한 구체예에서, 인플루엔자 HA에 특이적으로 결합하는 분리된 항체 또는 항원-결합 단편은 (a) 서열 번호: 108의 HCDR1, (b) 서열 번호: 110의 HCDR2; (c) 서열 번호: 112의 HCDR3; (d) 서열 번호: 116의 LCDR1; (e) 서열 번호: 118의 LCDR2 및 (f) 서열 번호: 120의 LCDR3을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 HCDR1 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 중쇄 CDR1 (HCDR1)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 HCDR2 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 중쇄 CDR2 (HCDR2)를 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 HCDR3 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 중쇄 CDR3 (HCDR3)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR1 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 경쇄 CDR1 (LCDR1)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR2 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 경쇄 CDR2 (LCDR2)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR3 아미노산 서열 중 어느 것으로부터 선택된 아미노산 서열, 또는 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함하는 경쇄 CDR3 (LCDR3)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR3 아미노산 서열 중 어느 것과 쌍을 이룬 표 1, 또는 표 12에서 나열된 HCDR3 아미노산 서열 중 어느 것을 포함하는 HCDR3 및 LCDR3 아미노산 서열 쌍 (HCDR3/LCDR3)을 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다. 특정 구체예에 따르면, 본 발명은 표 1, 또는 표 12에서 나열된 전형적인 항-인플루엔자 HA 항체 중 어느 것 내에 함유된 HCDR3/LCDR3 아미노산 서열 쌍을 포함하는 항체, 또는 이것들의 항원-결합 단편을 제공한다. 특정 구체예에서, HCDR3/LCDR3 아미노산 서열 쌍은 서열 번호: 24/32 (예를 들어, H1H11729P), 56/64 (예를 들어, H1H11829N), 56/72 (예를 들어 H1H11829N2) 및 112/120 (예를 들어, H1H14571N)으로 구성된 군으로부터 선택된다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 전형적인 항-인플루엔자 HA 항체 중 어느 것 내에 함유된 여섯 개의 CDR의 세트 (즉, HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3)를 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다. 특정 구체예에서, HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3 아미노산 서열 세트는 서열 번호: 20-22-24-28-30-32 (예를 들어, H1H11729P), 52-54-56-60-62-64 (예를 들어, H1H11829N); 52-54-56-68-70-72 (예를 들어 H1H11829N2) 및 108-110-112-116-118 및 120 (예를 들어, H1H14571N)으로 구성된 군으로부터 선택된다.
관련된 구체예에서, 본 발명은 표 1, 또는 표 12에서 나열된 전형적인 항-인플루엔자 HA 항체 중 어느 것에 의해 한정된 HCVR/LCVR 아미노산 서열 쌍 내에 함유된 여섯 개의 CDR의 세트 (즉, HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3)를 포함하는 항체, 또는 이것의 항원-결합 단편을 제공한다. 예를 들어, 본 발명은 서열 번호: 18/26 (예를 들어, H1H11729P), 50/58 (예를 들어, H1H11829N), 50/66 (예를 들어 H1H11829N2) 및 106/114 (예를 들어, H1H14571N)로 구성된 군으로부터 선택된 HCVR/LCVR 아미노산 서열 쌍 내에 함유된 HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3 아미노산 서열 세트를 포함하는 항체, 또는 이것의 항원-결합 단편을 포함한다. HCVR 및 LCVR 아미노산 서열 내에서 CDR을 확인하기 위한 방법 및 기술은 업계에 널리 공지되어 있으며 본원에서 개시되어 있는 명시된 HCVR 및/또는 LCVR 아미노산 서열 내에서 CDR을 확인하는데 사용될 수 있다. CDR의 경계를 확인하는데 사용될 수 있는 전형적인 사례는, 예를 들어, 카바트 정의(Kabat definition), 쵸티아 정의(Chothia definition), 및 AbM 정의를 포함한다. 일반적으로, 카바트 정의는 서열 가변성을 기반으로 하고, 쵸티아 정의는 구조적 루프 영역의 위치를 기반으로 하며, AbM 정의는 카바트 및 쵸티아 접근법 간의 절충안이다. 예를 들어, Kabat, "Sequences of Proteins of Immunological Interest," National Institutes of Health, Bethesda, Md. (1991); Al-Lazikani et al., J. Mol . Biol. 273:927-948 (1997); 및 Martin et al., Proc . Natl . Acad . Sci . USA 86:9268-9272 (1989) 참조. 항체 내에서 CDR 서열을 확인하는데 있어서 공개적인 데이터베이스가 또한 이용 가능하다.
본 발명은 변형된 글리코실화 패턴을 가진 항-인플루엔자 HA 항체를 포함한다. 일부 구체예에서, 원치않는 글리코실화 부위를 없애기 위한 변형, 또는 올리고당 사슬에 존재하는 푸코스 모이어티가 결여된 항체가, 예를 들어, 항체 의존성 세포 독성 (ADCC) 기능을 증가시키는데 유용할 수도 있다 (Shield et al. (2002) JBC 277:26733 참조). 다른 응용에서는, 보체 의존성 세포 독성 (CDC)을 변형시키기 위해 갈락토실화의 변형이 이루어질 수 있다.
본 발명은 또한 인플루엔자 HA로의 특이적 결합에 대하여 HCVR의 CDR 및 LCVR의 CDR을 포함하는 항체 또는 이것의 항원-결합 단편과 경쟁하는 항체 및 이것의 항원-결합 단편을 제공하며, HCVR 및 LCVR 각각은 표 1, 또는 표 12에서 나열된 HCVR 및 LCVR 서열로부터 선택된 아미노산 서열을 가진다.
본 발명은 또한 HCVR의 CDR 및 LCVR의 CDR을 포함하는 참조 항체 또는 이것의 항원-결합 단편으로서, 인플루엔자 HA로의 결합에 대하여 교차-경쟁하거나, 또는 인플루엔자 HA 상의 같은 에피토프에 결합하는 항체 및 이것의 항원-결합 단편을 제공하며, HCVR 및 LCVR 각각은 표 1, 또는 표 12에서 나열된 HCVR 및 LCVR 서열로부터 선택된 아미노산 서열을 가진다.
본 발명은 또한 숙주 세포로의 인플루엔자 HA 부착, 및/또는 진입을 차단하는 분리된 항체 및 이것들의 항원-결합 단편을 제공한다.
특정 구체예에서, 본 발명의 항체 또는 항원-결합 단편은 이중 특이적이며 인플루엔자 HA에서 제1 에피토프에 대한 제1 결합 특이성 및 또 다른 항원에 대한 제2 결합 특이성을 포함한다.
제2 양태에서, 본 발명은 항-인플루엔자 HA 항체 또는 그 일부를 암호화하는 핵산 분자를 제공한다. 예를 들어, 본 발명은 표 1, 또는 표 12에서 나열된 HCVR 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 HCVR 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCVR 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 LCVR 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 HCDR1 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 HCDR1 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 HCDR2 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 HCDR2 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 HCDR3 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 HCDR3 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR1 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 LCDR1 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR2 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 LCDR2 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 표 1, 또는 표 12에서 나열된 LCDR3 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공하고; 특정 구체예에서 핵산 분자는 표 2, 또는 표 13에서 나열된 LCDR3 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다.
본 발명은 또한 HCVR을 암호화하는 핵산 분자를 제공하는데, HCVR은 세 개의 CDR의 세트 (즉, HCDR1-HCDR2-HCDR3)를 포함하며, HCDR1-HCDR2-HCDR3 아미노산 서열 세트는 표 1, 또는 표 12에서 나열된 전형적인 항-인플루엔자 HA 항체 중 어느 것에 의해 정의된 바와 같다.
본 발명은 또한 LCVR을 암호화하는 핵산 분자를 제공하는데, LCVR은 세 개의 CDR의 세트 (즉, LCDR1-LCDR2-LCDR3)를 포함하며, LCDR1-LCDR2-LCDR3 아미노산 서열 세트는 표 1, 또는 표 12에서 나열된 전형적인 항-인플루엔자 HA 항체 중 어느 것에 의해 정의된 바와 같다.
본 발명은 또한 HCVR 및 LCVR 둘 다를 암호화하는 핵산 분자를 제공하는데, HCVR은 표 1, 또는 표 12에서 나열된 HCVR 아미노산 서열 중 어느 것의 아미노산 서열을 포함하고 LCVR은 표 1, 또는 표 12에서 나열된 LCVR 아미노산 서열 중 어느 것의 아미노산 서열을 포함한다. 특정 구체예에서, 핵산 분자는 표 2, 또는 표 13에서 나열된 HCVR 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열, 및 표 2에서 나열된 LCVR 핵산 서열 중 어느 것으로부터 선택된 폴리뉴클레오타이드 서열, 또는 그것에 대하여 적어도 90%, 적어도 95%, 적어도 98% 또는 적어도 99% 서열 동일성을 가지는 그것과 실질적으로 유사한 서열을 포함한다. 본 발명의 이 양태에 따르는 특정 구체예에서, 핵산 분자는 HCVR 및 LCVR을 암호화하며, HCVR 및 LCVR은 둘 다 표 1, 또는 표 12에서 나열된 같은 항-인플루엔자 HA 항체로부터 유도된다.
본 발명은 표 1, 또는 표 12에서 나열된 중쇄 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공한다. 본 발명은 또한 표 1, 또는 표 12에서 나열된 경쇄 아미노산 서열 중 어느 것을 암호화하는 핵산 분자를 제공한다.
관련 양태에서, 본 발명은 항-인플루엔자 HA 항체의 중쇄 또는 경쇄 가변 영역을 포함하는 폴리펩타이드를 발현할 수 있는 재조합 발현 벡터를 제공한다. 예를 들어, 본 발명은 상기 언급된 핵산 분자, 즉, 표 1, 또는 표 12에서 제시된 HCVR, LCVR, 및/또는 CDR 서열 중 어느 것을 암호화하는 핵산 분자 중 어느 것을 포함하는 재조합 발현 벡터를 포함한다. 또한 이러한 벡터가 도입되는 숙주 세포, 뿐만 아니라 항체 또는 항체 단편의 생산을 허용하는 조건 하에 숙주 세포를 배양하여 항체 또는 그 일부를 생산하고, 그렇게 생산된 항체 및 항체 단편을 회수하는 방법이 본 발명의 범위 내에 포함된다.
제3 양태에서, 본 발명은 인플루엔자 HA에 특이적으로 결합하는 적어도 하나의 재조합 단클론성 항체 또는 이것의 항원-결합 단편의 치료적 유효량 및 약학적으로 허용 가능한 담체를 포함하는 약학적 조성물을 제공한다. 관련 양태에서, 본 발명은 항-인플루엔자 HA 항체 및 제2 치료제의 조합인 조성물을 특징으로 한다. 한 구체예에서, 제2 치료제는 바람직하게는 항-인플루엔자 HA 항체와 조합되는 임의의 작용제이다. 바람직하게는 항-인플루엔자 HA 항체와 조합될 수도 있는 전형적인 작용제는, 제한이 아니라, 인플루엔자 HA에 결합하고 및/또는 인플루엔자 HA 활성을 억제하는 다른 작용제 (다른 항체 또는 이것의 항원-결합 단편, 등을 포함함) 및/또는 인플루엔자 HA에 직접적으로 결합하는 것은 아니지만 그럼에도 불구하고 숙주 세포의 감염성을 포함하는 바이러스 활성을 억제하는 작용제를 포함한다. 특정 구체예에서, 본 발명은 다음을 포함하는 약학적 조성물을 제공한다: (a) 제1 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편; (b) 제2 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편 (여기에서 제1 항체는 인플루엔자 HA 상의 제1 에피토프에 결합하고 제2 항체는 인플루엔자 HA 상의 제2 에피토프에 결합하고 제1 및 제2 에피토프는 별개이고 중첩되지 않는다); 및 (c) 약학적으로 허용 가능한 담체 또는 희석제. 특정 구체예에서, 본 발명은 다음을 포함하는 약학적 조성물을 제공한다: (a) 제1 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편; (b) 제2 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편 (여기에서 제1 항체는 인플루엔자 HA로의 결합에 대하여 제2 항체와 교차-경쟁하지 않는다); 및 (c) 약학적으로 허용 가능한 담체 또는 희석제. 특정 구체예에서, 본 발명은 다음을 포함하는 약학적 조성물을 제공한다: (a) 제1 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편; (b) 다른 인플루엔자 항원과 상호작용하는 제2 항-인플루엔자 항체 또는 이것의 항원-결합 단편 (여기에서 제1 항체는 인플루엔자 HA 상의 에피토프에 결합하고 제2 항체는 다른 인플루엔자 항원 상의 에피토프에 결합한다); 및 (c) 약학적으로 허용 가능한 담체 또는 희석제. 특정 구체예에서, 본 발명은 다음을 포함하는 약학적 조성물을 제공한다: (a) 제1 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편; (b) 다른 바이러스 (비-인플루엔자) 항원과 상호작용하는 제2 항체 또는 이것의 항원-결합 단편 (여기에서 제1 항체는 인플루엔자 HA 상의 에피토프에 결합하고 제2 항체는 다른 바이러스 (비-인플루엔자) 항원 상의 에피토프에 결합한다); 및 (c) 약학적으로 허용 가능한 담체 또는 희석제. 본 발명의 항-인플루엔자 HA 항체를 수반하는 추가적인 조합 요법 및 통합제형(co-formulation)은 본원의 다른 곳에서도 개시되어 있다.
제4 양태에서, 본 발명은 본 발명의 항-인플루엔자 HA 항체 또는 항체의 항원-결합 부분을 사용하여 인플루엔자 HA와 관련된 질환 또는 장애 (예컨대 대상체의 바이러스 감염), 또는 바이러스 감염과 관련된 적어도 하나의 증상을 치료하기 위한 치료 방법을 제공하는데, 치료 방법은 본 발명의 항체 또는 항체의 항원-결합 단편을 포함하는 약학적 조성물의 치료적 유효량을 필요로 하는 대상체에게 투여하는 단계를 포함한다. 치료되는 장애는 인플루엔자 HA 활성의 억제에 의해 개선, 경감, 억제 또는 예방되는 임의의 질환 또는 상태이다. 특정 구체예에서, 본 발명은 인플루엔자 A 감염의 적어도 하나의 증상을 예방, 치료 또는 경감하는 방법을 제공하며, 방법은 본 발명의 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편의 치료적 유효량을 필요로 하는 대상체에게 투여하는 단계를 포함한다.
일부 구체예에서, 본 발명은 본 발명의 항-인플루엔자 HA 항체를 투여함으로써 대상체의 인플루엔자 감염의 적어도 하나의 증상의 심각도, 기간, 또는 발병 빈도를 경감 또는 감소시키는 방법을 제공하며, 적어도 하나의 증상은 두통, 열, 통증, 비루(rhinorrhea) (비충혈(nasal congestion)), 오한, 피로, 쇠약, 인두통, 기침, 숨가쁨, 구토, 설사, 폐렴(pneumonia), 기관지염(bronchitis), 및 사망으로 구성된 군으로부터 선택된다.
특정 구체예에서, 본 발명은 대상체에서 바이러스량을 감소시키는 방법을 제공하며, 방법은 인플루엔자 HA에 결합하여 숙주 세포로의 인플루엔자 HA 결합 및/또는 진입을 차단하는 본 발명의 항체 또는 이것의 단편의 유효량을 대상체에게 투여하는 단계를 포함한다.
특정 구체예에서, 항체 또는 이것의 항원-결합 단편은 인플루엔자에 감염되었거나, 인플루엔자에 감염될 위험이 있거나, 또는 인플루엔자 감염에 취약한 대상체에게 예방적으로 또는 치료적으로 투여될 수도 있다. 위험이 있는 대상체는 면역 손상된 사람, 예를 들어, 자가면역 질환으로 인해 면역 손상된 사람, 또는 면역억제 치료를 받은 상기 사람 (예를 들어, 장기 이식 후), 또는 백혈구를 고갈시키거나 파괴하는 빈혈증의 특정 형태인 인간 면역 결핍 증후군 (human immunodeficiency syndrome; HIV) 또는 후천성 면역 결핍 증후군 (acquired immune deficiency syndrome; AIDS)을 앓고 있는 상기 사람, 방사선 또는 화학요법을 받은 상기 사람, 또는 염증성 장애를 앓고 있는 상기 사람을 포함하지만, 이에 제한되는 것은 아니다. 인플루엔자에 감염될 위험이 있는 다른 대상체는 고령의 성인 (65살 초과), 2살 미만의 아동, 의료계 종사자, 및 폐 감염, 심장 질환 또는 당뇨병과 같은 기저 질환에 걸린 사람들을 포함한다. 또한, 감염된 개체와 육체적으로 접촉하거나 물리적으로 근접한 임의의 사람도 인플루엔자 바이러스에 감염될 위험이 증가된다. 더욱이, 대상체는 질환의 발병과의 근접함으로 인해, 예를 들어, 대상체는 인구 밀집 도시 또는 인플루엔자 바이러스에 감염된 것으로 확인되거나 의심되는 대상체와 가까이에 거주하기 때문에, 또는 직장의 선택, 예를 들어, 병원 근로자, 제약 연구원, 감염 지역의 여행자, 또는 상용 비행 고객(frequent flier)으로 인해 인플루엔자에 감염될 위험이 있다.
특정 구체예에서, 본 발명의 항체 또는 이것의 항원-결합 단편은 제2 치료제와 조합하여 필요로 하는 대상체에게 투여된다. 제2 치료제는 항염증제 (예컨대 코르티코스테로이드, 및 비-스테로이드계 항염증제), 항감염제, 인플루엔자 HA에 대한 다른 항체, 다른 인플루엔자 항원 (예를 들어, 뉴라미니다제)에 대한 항체, 항바이러스제, 충혈완화제, 항히스타민제, 인플루엔자용 백신, 식이보조제, 예컨대 항산화제 및 환자에서 인플루엔자 감염의 적어도 하나의 증상을 경감시키거나, 바이러스량을 감소시키는데 유용한, 업계에 공지되어 있는 임의의 다른 약물 또는 요법으로 구성된 군으로부터 선택될 수도 있다. 특정 구체예에서, 제2 치료제는 본 발명의 항체 또는 이것의 항원-결합 단편과 관련된 임의의 가능한 부작용(들)이 발생하는 경우, 이러한 부작용(들)에 대응하거나 이것들을 감소시키는 것을 돕는 작용제일 수도 있다. 항체 또는 이것의 단편은 피하로, 정맥 내로, 피부 내로, 복강 내로, 경구로, 비강 내로, 근육 내로, 또는 두개 내로 투여될 수도 있다. 한 구체예에서, 항체는 대상체의 혈청에서 최대 농도의 항체에 대하여 1회 정맥 내 주입으로서 투여될 수도 있다. 항체 또는 이것의 단편은 약 0.01 mg/대상체의 체중 kg 내지 약 100 mg/체중 kg의 용량으로 투여될 수도 있다. 특정 구체예에서, 본 발명의 항체는 50 mg 내지 5000 mg을 포함하는 1회 이상의 용량으로 투여될 수도 있다.
본 발명은 또한 인플루엔자 HA 결합 및/또는 활성의 차단으로부터 이익을 얻는 질환 또는 장애의 치료를 위해 본 발명의 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편의 사용을 포함한다. 본 발명은 또한 인플루엔자 HA 결합 및/또는 활성의 차단으로부터 이익을 얻는 질환 또는 장애의 치료를 위한 의약의 제조시 본 발명의 항-인플루엔자 HA 항체 또는 이것의 항원-결합 단편의 사용을 포함한다.
다른 구체예들은 하기 상세한 설명의 재검토로부터 명백해질 것이다.
도 1. 마우스에서 중증 인플루엔자 A 바이러스 감염을 치료하는데 있어서 감염 후 48시간에 H1H11729P의 1회 용량이 감염 후 48시간에 오셀타미비르보다 더 큰 효험을 나타냄을 도시한다. 15 mg/kg (원)으로 48 h p.i.에 제공된 H1H11729P의 1회 용량은 25 (역삼각형) 또는 5 mg/kg (다이아몬드)으로 감염 후 제2 일에 시작하여 5일 동안 1일 2회 (BID) 투여된 오셀타미비르 (Tamiflu®)보다 더 효과적이다. 마우스는 제0 일에 10 x MLD50의 A/Puerto Rico/08/1934 (H1N1)로 비강 내로 (IN) 감염되었다. 대조군은 미감염군 (삼각형, 점선) 및 IgG1 아이소타입 (음성) 대조군으로서 물 및 CR8020의 경구 위관 영양법(oral gavage)을 받은 감염군 (육각형)을 포함하였다.
도 2. 마우스에서 중증 인플루엔자를 치료하기 위해 감염 후 72시간에 H1H11729P의 1회 용량이 오셀타미비르와 조합될 때 추가적인 효험이 관찰됨을 도시한다. 마우스는 10 x MLD50의 A/Puerto Rico/08/1934 (H1N1)으로 비강 내 (IN) 감염 후 72시간에 5일 동안 7 (사각형, 점선) 또는 15 mg/kg의 H1H11729P (원, 점선), 대조군 IgG (삼각형), 25 mg/kg BID 오셀타미비르 (다이아몬드, 점선)의 1회 유효량 미만의 (sub-efficacious) 용량 또는 5일 동안 7 (사각형, 실선) 또는 15 mg/kg H1H11729P (원, 실선)의 1회 용량과 오셀타미비르 요법의 조합을 받았다. 세 번의 독립적인 시험 (군 당 N=15)의 결과가 도시된다.
도 3. H1H11729P로 지칭되는 항체에 대한 HCVR, HCDR1, HCDR2, HCDR3, LCVR, LCDR1, LCDR2 및 LCDR3 아미노산 서열을 도시한다.
도 4. H1H11829N2로 지칭되는 항체에 대한 HCVR, HCDR1, HCDR2, HCDR3, LCVR, LCDR1, LCDR2 및 LCDR3 아미노산 서열을 도시한다.
본 발명을 설명하기 전에, 본 발명은 특정 방법, 및 실험 조건에 제한되지 않으며, 이러한 방법 및 조건은 달라질 수도 있음을 이해해야 한다. 또한 본 발명의 범위는 단지 첨부된 청구범위에 의해서만 제한되기 때문에, 본원에서 사용된 용어는 단지 특정 구체예를 기술할 목적을 위한 것이고, 제한하려는 의도가 아님을 이해해야 한다.
달리 정의되지 않는 한, 본원에서 사용된 모든 기술적 및 과학적 용어는 본 발명이 속한 업계의 당업자에 의해 일반적으로 이해되는 바와 같은 의미를 가진다. 본원에서 기술된 것들과 유사하거나 동등한 임의의 방법 및 재료가 본 발명의 실행 및 검사에 사용될 수 있지만, 바람직한 방법 및 재료들은 지금부터 기술된다.
정의
"인플루엔자 HA"라고도 불리는 용어 "인플루엔자 헤마글루티닌"은 인플루엔자 비리온의 표면 상에서 발견되는 트리머 당단백질이며, 이것은 숙주 세포로의 바이러스 부착 (α-2,3- 및 α-2,6-시알산으로의 HA1 결합을 통해) 및 진입 (입체구조적 변화를 통해)을 매개한다. HA는 두 개의 구조적 도메인으로 구성된다: 수용체 결합 부위 (높은 빈도의 항원 돌연변이에 대한 대상)를 함유하는 구상 머리 도메인 및 줄기 영역 (인플루엔자 바이러스의 다양한 균주들 중에서 더 많이 보존됨). 인플루엔자 HA는 서로 회합하여 줄기/구상 머리 구조를 형성하는 두 개의 서브유닛 (HA1 및 HA2)을 생산하기 위해 단백질 가수분해 과정을 거치는 전구체 (HA0)로서 합성된다. 바이러스 HA는 바이러스에서 가장 가변적인 항원이지만 (18개의 서브타입이 두 개의 군으로 분류될 수 있다), 줄기 (HA2)는 각 군 내에서 고도로 보존된다.
전장 인플루엔자 HA의 아미노산 서열은 GenBank에서 수탁 번호 FJ966082.1로서 제공된 인플루엔자 분리체 H1N1 A/California/04/2009의 아미노산 서열에 의해 예시된다. 용어 "인플루엔자-HA"는 또한 다른 인플루엔자 분리체, 예를 들어, GQ149237.1, NC_002017, KM972981.1, 등으로부터 분리된 인플루엔자 HA의 단백질 변이체를 포함한다. 용어 "인플루엔자-HA"는 또한 재조합 인플루엔자 HA 또는 이것의 단편을 포함한다. 용어는 또한, 예를 들어, 히스티딘 태그, 마우스 또는 인간 Fc, 또는 신호 서열에 커플링된 인플루엔자 HA 또는 이것의 단편을 포함한다.
"독감"으로도 특징지어지는, 용어 "인플루엔자 감염"은, 본원에서 사용된 바와 같이, 인플루엔자 바이러스에 의해 유발되는 중증 급성 호흡기 질환을 말한다. 용어는 기도 감염 및 고열, 두통, 일반적인 통증 및 고통, 피로 및 쇠약, 경우에 따라 극도의 에너지 고갈(extreme exhaustion), 코막힘, 재채기, 인두통, 흉부 불쾌감, 기침, 숨가쁨, 기관지염, 폐렴 및 극심한 경우에는 사망을 포함하는 증상들을 포함한다.
용어 "항체"는, 본원에서 사용된 바와 같이, 이황화 결합에 의해 서로 연결된 네 개의 폴리펩타이드 사슬, 두 개의 중쇄 (H) 및 두 개의 경쇄 (L)로 구성된 면역글로불린 분자 (즉, "전체 항체 분자"), 뿐만 아니라 이것의 멀티머 (예를 들어 IgM) 또는 이것의 항원-결합 단편을 지칭하려는 것이다. 각각의 중쇄는 중쇄 가변 영역 ("HCVR" 또는 "VH") 및 중쇄 불변 영역 (도메인 CH1, CH2 및 CH3으로 구성됨)으로 구성된다. 각각의 경쇄는 경쇄 가변 영역 ("LCVR 또는 "VL") 및 경쇄 불변 영역 (CL)으로 구성된다. VH 및 VL 영역은 프레임워크 영역 (FR)으로 불리는 더 보존된 영역과 산재된, 상보성 결정 영역 (CDR)으로 불리는 초 가변성의 영역으로 더 세분화될 수 있다. VH 및 VL는 아미노-말단에서 카르복시-말단으로 다음의 순서로 배열된 세 개의 CDR 및 네 개의 FR로 구성된다: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4. 본 발명의 특정 구체예에서, 항체 (또는 이것의 항원 결합 단편)의 FR은 인간 생식세포 계열 서열과 동일할 수도 있거나, 자연적으로 또는 인공적으로 변형될 수도 있다. 아미노산 공통 서열은 둘 이상의 CDR의 사이드-바이-사이드(side-by-side) 분석을 기반으로 하여 정의될 수 있다.
하나 이상의 CDR 잔기의 치환 또는 하나 이상의 CDR의 누락이 또한 가능하다. 결합을 위해 하나 또는 두 개의 CDR이 생략될 수 있는 항체가 과학 문헌에서 기술되었다. Padlan 등 (1995 FASEB J. 9:133-139)은 공개된 결정 구조를 기반으로 항체와 그 항원 사이의 불변 영역을 분석하였고, CDR 잔기들 중 약 5분의 1 내지 3분의 1만이 실제로 항원에 접촉한다는 결론을 내렸다. Padlan은 또한 하나 또는 두 개의 CDR에 항원과 접촉된 아미노산이 없는 많은 항체를 발견하였다 (Vajdos et al. 2002 J Mol Biol 320:415-428 참조).
항원과 접촉하지 않은 CDR 잔기는 이전 연구 (예를 들어 CDRH2에서 잔기 H60-H65는 종종 필요하지 않음)에 기초하여, 분자 모델링에 의해 및/또는 경험에 의해 쵸티아 CDR의 바깥에 있는 카바트 CDR의 영역으로부터 확인될 수 있다. CDR 또는 이것의 잔기(들)가 누락되면, 그것은 보통 또 다른 인간 항체 서열 또는 이러한 서열들의 공통 서열에서 해당하는 위치를 점유하는 아미노산으로 치환된다. CDR 내에서 치환되는 위치 및 치환하기 위한 아미노산 또한 경험적으로 선택될 수 있다. 경험적 치환은 보존적 또는 비-보존적 치환일 수 있다.
본원에서 개시된 완전 인간 항-인플루엔자-HA 단클론성 항체는 해당하는 생식세포 계열 서열과 비교된 바와 같이 중쇄 및 경쇄 가변 도메인의 프레임워크 및/또는 CDR 영역에서 하나 이상의 아미노산 치환, 삽입 및/또는 결실을 포함할 수도 있다. 이러한 돌연변이는 본원에서 개시된 아미노산 서열을, 예를 들어, 공개 항체 서열 데이터베이스로부터 이용 가능한 생식세포 계열 서열과 비교함으로써 쉽게 확인될 수 있다. 본 발명은 본원에서 개시된 아미노산 서열 중 어느 것으로부터 유도된 항체, 및 이것의 항원-결합 단편을 포함하며, 하나 이상의 프레임워크 및/또는 CDR 영역 내에서 하나 이상의 아미노산이 항체가 유도된 생식세포 계열 서열의 해당 잔기(들)로, 또는 또 다른 인간 생식세포 계열 서열의 해당 잔기(들)로, 또는 해당 생식세포 계열 잔기(들)의 보존적 아미노산 치환으로 돌연변이된다 (이러한 서열 변화는 본원에서는 일괄적으로 "생식세포 계열 돌연변이"라고 불린다). 당업자들은, 본원에서 개시된 중쇄 및 경쇄 가변 영역 서열로 시작하여, 하나 이상의 개개의 생식세포 계열 돌연변이 또는 이것들의 조합을 포함하는 많은 항체 및 항원-결합 단편을 쉽게 생산할 수 있다. 특정 구체예에서, VH 및/또는 VL 도메인 내 모든 프레임워크 및/또는 CDR 잔기는 항체가 유도된 원래의 생식세포 계열 서열에서 발견된 잔기로 다시 돌연변이된다. 다른 구체예에서, 특정 잔기들, 예를 들어, FR1의 처음 8개의 아미노산 또는 FR4의 마지막 8개의 아미노산 내에서 발견된 돌연변이된 잔기, 또는 CDR1, CDR2 또는 CDR3 내에서 발견된 돌연변이된 잔기들만 원래의 생식세포 계열 서열로 다시 돌연변이된다. 다른 구체예에서, 프레임워크 및/또는 CDR 잔기(들) 중 하나 이상은 다른 생식세포 계열 서열 (즉, 항체가 원래 유도된 생식세포 계열 서열과 다른 생식세포 계열 서열)의 해당 잔기(들)로 돌연변이된다. 게다가, 본 발명의 항체는 프레임워크 및/또는 CDR 영역 내에서 둘 이상의 생식세포 계열 돌연변이의 임의의 조합을 포함할 수도 있으며, 예를 들어, 특정 개개의 잔기들은 특정한 생식세포 계열 서열의 해당 잔기로 돌연변이되는 한편 원래의 생식세포 계열 서열과 다른 특정 다른 잔기들은 유지되거나 다른 생식세포 계열 서열의 해당 잔기로 돌연변이된다. 획득하면, 하나 이상의 생식세포 계열 돌연변이를 함유하는 항체 및 항원-결합 단편은 하나 이상의 원하는 성질, 예컨대 개선된 결합 특이성, 증가된 결합 친화도, 개선된 또는 향상된 안타고니스트 또는 아고니스트의 생물학적 성질 (경우에 따라), 감소된 면역원성, 등에 대하여 쉽게 테스트될 수 있다. 이러한 일반적인 방식으로 획득한 항체 및 항원-결합 단편은 본 발명 내에 포함된다.
본 발명은 또한 하나 이상의 보존적 치환을 가지는, 본원에서 개시된 HCVR, LCVR, 및/또는 CDR 아미노산 서열 중 어느 것의 변이체를 포함하는 완전 인간 항-인플루엔자-HA 단클론성 항체를 포함한다. 예를 들어, 본 발명은 본원에서 개시된 HCVR, LCVR, 및/또는 CDR 아미노산 서열 중 어느 것과 비교하여, 예를 들어, 10개 이하, 8개 이하, 6개 이하, 4개 이하, 등의 보존적 아미노산이 치환된 HCVR, LCVR, 및/또는 CDR 아미노산 서열을 가지는 항-인플루엔자-HA 항체를 포함한다.
용어 "인간 항체"는, 본원에서 사용된 바와 같이, 인간 생식세포 계열 면역글로불린 서열로부터 유도된 가변 및 불변 영역을 가지는 항체를 포함하도록 의도된다. 본 발명의 인간 mAb는, 예를 들어 CDR 및 특히 CDR3에서, 인간 생식세포 계열 면역글로불린 서열 (예를 들어, 시험관 내에서 무작위 또는 부위-특이적 돌연변이 유발 또는 생체 내에서 체세포 돌연변이에 의해 도입된 돌연변이)에 의해 암호화되지 않는 아미노산 잔기를 포함할 수도 있다. 하지만, 용어 "인간 항체"는, 본원에서 사용된 바와 같이, 또 다른 포유류 종 (예를 들어, 마우스)의 생식세포 계열로부터 유도된 CDR 서열이 인간 FR 서열로 이식된 mAb를 포함하도록 의도된 것은 아니다. 용어는 비-인간 포유동물에서, 또는 비-인간 포유동물의 세포에서 재조합에 의해 생산된 항체를 포함한다. 용어는 인간 대상체로부터 분리되거나 인간 대상체에서 생산된 항체를 포함하도록 의도된 것은 아니다.
용어 "재조합체"는, 본원에서 사용된 바와 같이, 예를 들어, DNA 스플라이싱(splicing) 및 트랜스제닉(transgenic) 발현을 포함하는 재조합 DNA 기술로서 업계에 공지되어 있는 기술 또는 방법에 의해 생성, 발현, 분리 또는 획득되는 본 발명의 항체 또는 이것의 항원-결합 단편을 말한다. 용어는 비-인간 포유동물 (트랜스제닉 비-인간 포유동물, 예를 들어, 트랜스제닉 마우스 포함), 또는 세포 (예를 들어, CHO 세포) 발현 시스템에서 발현되거나 재조합체 조합 인간 항체 라이브러리에서 분리된 항체를 말한다.
용어 "특이적으로 결합하다", 또는 "~에 특이적으로 결합하다", 등은 항체 또는 이것의 항원-결합 단편이 생리학적 조건 하에 비교적 안정한 항원과 복합체를 형성한다는 것을 의미한다. 특이적 결합은 적어도 약 1x10-8 M 이하의 평형 해리 상수를 특징으로 할 수 있다 (예를 들어, 더 낮은 KD는 더 단단한 결합을 나타낸다). 두 개의 분자가 특이적으로 결합하는지를 결정하는 방법은 업계에 널리 공지되어 있으며, 예를 들어, 평형 투석, 표면 플라스몬 공명(surface plasmon resonance) 등을 포함한다. 본원에서 기술된 바와 같이, 인플루엔자-HA에 특이적으로 결합하는 항체는 Octet® HTX 바이오센서에서 실시간, 무라벨 생체막 간섭 검정으로 확인되었다. 더욱이, 인플루엔자-HA의 하나의 도메인 및 하나 이상의 추가적인 항원에 결합하는 다중-특이적 항체 또는 인플루엔자-HA의 두 개의 다른 영역에 결합하는 이중-특이적 항체는 그럼에도 불구하고, 본원에서 사용된 바와 같이, "특이적으로 결합하는" 항체로 간주된다.
용어 "고친화도" 항체는 실시간, 무라벨 생체막 간섭 검정, 예를 들어, Octet® HTX 바이오센서에 의해, 또는 표면 플라스몬 공명, 예를 들어, BIACORE™에 의해, 또는 용액-친화도 ELISA에 의해 측정된 바와 같이, KD로 표현되는, 인플루엔자-HA에 대하여 적어도 10-8 M; 바람직하게는 10-9 M; 더 바람직하게는 10-10M, 더 바람직하게는 10-11 M, 더 바람직하게는 10-12 M의 결합 친화도를 가지는 상기 mAb를 말한다.
용어 "슬로우 오프 속도(slow off rate)", "Koff" 또는 "kd"는 실시간, 무라벨 생체막 간섭 검정, 예를 들어, Octet® HTX 바이오센서, 또는 표면 플라스몬 공명, 예를 들어, BIACORE™에 의해 결정된 바와 같이, 1 x 10-3 s-1 이하, 바람직하게는 1 x 10-4 s-1 이하의 속도 상수로 인플루엔자-HA로부터 해리되는 항체를 의미한다.
용어 항체의 "항원-결합 부분", "항원-결합 단편", 등은, 본원에서 사용된 바와 같이, 항원에 특이적으로 결합하여 복합체를 형성하는, 자연 발생하거나, 효소에 의해 획득 가능하거나, 합성되거나, 또는 유전적으로 조작된 임의의 폴리펩타이드 또는 당단백질을 포함한다. 용어 항체의 "항원-결합 단편", 또는 "항체 단편"은, 본원에서 사용된 바와 같이, 인플루엔자 HA에 결합하는 능력을 보유한 항체의 하나 이상의 단편을 말한다.
구체적인 구체예에서, 본 발명의 항체 또는 항체 단편은 리간드 또는 치료적 모이어티 ("면역컨쥬게이트(immunoconjugate)")와 같은 모이어티, 예컨대 항바이러스제, 제2 항-인플루엔자 항체, 또는 인플루엔자-HA에 의해 유발된 감염을 치료하는데 유용한 임의의 다른 치료적 모이어티에 컨쥬게이션될 수도 있다.
"분리된 항체"는, 본원에서 사용된 바와 같이, 다른 항원 특이성을 가지는 다른 항체 (Ab)가 실질적으로 없는 항체를 나타내도록 의도된다 (예를 들어, 인플루엔자-HA, 또는 이것의 단편에 특이적으로 결합하는 분리된 항체는 인플루엔자-HA 이외의 항원에 특이적으로 결합하는 Ab가 실질적으로 없다).
"차단 항체" 또는 "중화 항체" (또는 "인플루엔자-HA 활성을 중화시키는 항체" 또는 "안타고니스트 항체")는, 본원에서 사용된 바와 같이, 인플루엔자-HA로의 결합이 인플루엔자-HA의 적어도 하나의 생물학적 활성의 억제를 초래하는 항체를 나타내도록 의도된다. 예를 들어, 본 발명의 항체는 숙주 세포로의 인플루엔자 부착, 또는 진입을 방지하거나 차단할 수도 있다. 이에 더하여, "중화 항체"는 숙주에서 감염을 시작하고 및/또는 영속시키는 병원체의 능력을 중화시킬 수 있는 것, 즉, 상기 능력을 예방하거나, 억제하거나, 감소시키거나, 지연시키거나 또는 방해할 수 있는 것이다. 용어 "중화 항체" 및 "~를 중화시키는 항체" 또는 "~를 중화시키는 항체들"은 본원에서 교체 가능하게 사용된다. 이 항체들은 적절한 제형화 시에 예방제 또는 치료제로서, 단독으로 또는 다른 항바이러스제와 조합으로, 또는 활성 백신 접종과 함께, 또는 진단 도구로서 사용될 수 있다.
용어 "표면 플라스몬 공명"은, 예를 들어, BIACORE™ 시스템 (Pharmacia Biosensor AB, Uppsala, Sweden and Piscataway, N.J)을 사용하여 바이오센서 매트릭스 내 단백질 농도 변화의 검출에 의한 실시간 생체분자 상호작용의 분석을 허용하는 광학적 현상을 말한다.
생체막 간섭법은 생체분자 상호작용을 측정하기 위한 무라벨 기술이다. 그것은 두 개의 표면, 바이오센서 팁 상의 고정 단백질 층, 및 내부 참조 층으로부터 반사된 백색광의 간섭 패턴을 분석하는 광학적 분석 기술이다.
바이오센서 팁에 결합된 분자 수의 변화는 실시간으로 측정될 수 있는 간섭 패턴의 변화를 유발한다 (Abdiche, Y.N., et al. Analytical Biochemistry, (2008), 377(2), 209-217). 본 발명의 특정 구체예에서, "실시간 생체막 간섭계 기반 바이오센서 (Octet HTX 검정)"은 특정 항-인플루엔자 HA 항체의 결합 특징을 평가하는데 사용되었다.
용어 "KD"는, 본원에서 사용된 바와 같이, 특정 항체-항원 상호작용의 평형 해리 상수를 나타내도록 의도된다.
용어 "에피토프"는 파라토프로서 공지되어 있는 항체 분자의 가변 영역에서 특이적 항원-결합 부위와 상호작용하는 항원성 결합요인을 말한다. 단일 항원은 하나 이상의 에피테포를 가질 수도 있다. 따라서, 다른 항체는 항원 상에서 다른 구역에 결합할 수도 있고 다른 생물학적 효과를 가질 수도 있다. 용어 "에피토프"는 또한 B 및/또는 T 세포가 반응하는 항원 상의 부위를 말한다. 그것은 또한 항체에 의해 결합되는 항원의 영역을 말한다. 에피토프는 구조적 또는 기능적으로서 정의될 수도 있다. 기능적 에피토프는 일반적으로 구조적 에피토프의 서브세트이고 상호작용의 친화도에 직접적으로 기여하는 상기 잔기들을 가진다. 에피토프는 또한 입체구조적일 수도 있으며, 즉, 비-선형 아미노산으로 구성된다. 특정 구체예에서, 에피토프는 분자의 화학적 활성 표면 집단인 결정요인, 예컨대 아미노산, 당 측쇄, 포스포릴 기, 또는 설포닐 기를 포함할 수도 있으며, 특정 구체예에서는, 특이적 3차원 구조적 특징, 및/또는 특이적 전하 특징을 가질 수도 있다.
용어 "교차-경쟁하다"는, 본원에서 사용된 바와 같이, 항체 또는 이것의 항원-결합 단편이 항원에 결합하여 또 다른 항체 또는 이것의 항원-결합 단편의 결합을 억제하거나 차단함을 의미한다. 용어는 또한 두 방향으로 두 개의 항체, 즉, 제2 항체에 결합하여 제2 항체의 결합을 차단하는 제1 항체 및 그 반대 간의 경쟁을 포함한다. 특정 구체예에서, 제1 항체 및 제2 항체는 같은 에피토프에 결합할 수도 있다. 대안으로, 제1 및 제2 항체는, 예를 들어, 입체 장애(steric hindrance)를 통해 하나의 결합이 제2 항체의 결합을 억제하거나 차단하도록, 다르지만, 중첩된 에피토프에 결합할 수도 있다. 항체 간의 교차-경쟁은 업계에 공지되어 있는 방법에 의해, 예를 들어, 실시간, 무라벨 생체막 간섭 검정에 의해 측정될 수도 있다. 두 항체 간의 교차-경쟁은 자체 결합으로 인해 백그라운드 신호보다 낮은 제2 항체의 결합으로 표현될 수도 있다 (여기에서 제1 및 제2 항체는 같은 항체이다). 두 항체 간의 교차-경쟁은, 예를 들어, 베이스라인 자체 백그라운드 결합보다 낮은 제2 항체의 % 결합으로서 표현될 수도 있다 (여기에서 제1 및 제2 항체는 같은 항체이다).
핵산 또는 이것의 단편을 나타낼 때, 용어 "실질적 동일성" 또는 "실질적으로 동일한"은, 하기 논의된 바와 같이, 적절한 뉴클레오타이드 삽입 또는 결실로 또 다른 핵산 (또는 그것의 상보적 가닥)과 최적으로 정렬될 때, FASTA, BLAST 또는 GAP와 같은, 서열 동일성의 임의의 널리 공지된 알고리즘에 의해 측정된 바와 같이, 뉴클레오타이드 염기 중 적어도 약 90%, 및 더 바람직하게는 적어도 약 95%, 96%, 97%, 98% 또는 99%에서 뉴클레오타이드 서열 동일성이 존재함을 나타낸다. 참조 핵산 분자에 대하여 실질적 동일성을 가지는 핵산 분자는, 어떤 경우에는, 참조 핵산 분자에 의해 암호화된 폴리펩타이드와 같거나 실질적으로 유사한 아미노산 서열을 가지는 폴리펩타이드를 암호화할 수도 있다.
폴리펩타이드에 적용된 바와 같이, 용어 "실질적 유사성" 또는 실질적으로 유사한"은 두 개의 펩타이드 서열이, 예컨대 기본 갭 중량을 사용하는 프로그램 GAP 또는 BESTFIT에 의해 최적으로 정렬될 때, 적어도 90% 서열 동일성, 더 바람직하게는 적어도 95%, 98% 또는 99% 서열 동일성을 공유함을 의미한다. 바람직하게는, 동일하지 않은 잔기 위치는 보존적 아미노산 치환이 다르다. "보존적 아미노산 치환"은 아미노산 잔기가 유사한 화학적 성질 (예를 들어, 전하 또는 소수성)을 가진 측쇄 (R 기)를 가지는 또 다른 아미노산 잔기로 치환되는 것이다. 일반적으로, 보존적 아미노산 치환은 단백질의 기능적 성질을 실질적으로 변화시키지는 않을 것이다. 두 개 이상의 아미노산 서열이 보존적 치환에 의해 서로 다른 경우에는, 치환의 보존적 성질을 보정하기 위해서 유사성의 퍼센트 또는 정도가 상향 조정될 수도 있다. 이 조정 방법은 당업자에게 널리 공지되어 있다 (예를 들어, Pearson (1994) Methods Mol. Biol. 24: 307-331 참조). 유사한 화학적 성질을 가진 측쇄를 가지는 아미노산의 군의 예는 1) 지방족 측쇄: 글리신, 알라닌, 발린, 류신 및 아이소류신; 2) 지방족-하이드록실 측쇄: 세린 및 트레오닌; 3) 아미드-함유 측쇄: 아스파라긴 및 글루타민; 4) 방향족 측쇄: 페닐알라닌, 티로신, 및 트립토판; 5) 염기성 측쇄: 리신, 아르기닌, 및 히스티딘; 6) 산성 측쇄: 아스파르테이트 및 글루타메이트, 및 7) 황-함유 측쇄: 시스테인 및 메티오닌을 포함한다. 바람직한 보존적 아미노산 치환기는 발린-류신-아이소류신, 페닐알라닌-티로신, 리신-아르기닌, 알라닌-발린, 글루타메이트-아스파르테이트, 및 아스파라긴-글루타민이다. 대안으로, 보존적 대체는 Gonnet et al. (1992) Science 256: 1443 45에서 개시된 PAM250 로그-우도 매트릭스(log-likelihood matrix)에서 양의 값을 갖는 임의의 변화이다. "중간 정도로 보존적" 대체는 PAM250 로그-우도 매트릭스에서 비음의 (nonnegative) 값을 가지는 임의의 변화이다.
폴리펩타이드에 대한 서열 유사성은 전형적으로 서열 분석 소프트웨어를 사용하여 측정된다. 단백질 분석 소프트웨어는 다양한 치환, 결실 및 보존적 아미노산 치환을 포함한 다른 변형에 할당된 유사성의 측정값을 사용하여 유사한 서열을 매칭시킨다(match). 예를 들어, GCG 소프트웨어는, 밀접하게 관련된 폴리펩타이드, 예컨대 다른 종의 유기체의 상동성 폴리펩타이드 또는 야생형 단백질 및 이것의 돌연변이 단백질 간의 서열 상동성 또는 서열 동일성을 결정하기 위해 기본 파라미터와 함께 사용될 수 있는 프로그램, 예컨대 GAP 및 BESTFIT를 함유한다. 예를 들어, GCG Version 6.1 참조. 폴리펩타이드 서열은 또한 기본 또는 권장 파라미터를 이용한 FASTA; GCG Version 6.1의 프로그램을 사용하여 비교될 수 있다. FASTA (예를 들어, FASTA2 및 FASTA3)는 의문 서열 및 검색 서열 사이에서 최선의 중첩 영역의 정렬 및 퍼센트 서열 동일성을 제공한다 (Pearson (2000) supra). 본 발명의 서열을 다른 유기체의 많은 서열들을 함유하는 데이터베이스와 비교할 때, 또 다른 바람직한 알고리즘은 기본 변수를 사용하는 컴퓨터 프로그램 BLAST, 특히 BLASTP 또는 TBLASTN이다. 예를 들어, Altschul et al. (1990) J. Mol. Biol. 215: 403-410 및 (1997) Nucleic Acids Res. 25:3389-3402 참조.
구절 "치료적 유효량"은 투여되어 원하는 효과를 생산하는 양을 의미한다. 정확한 양은 치료 목적에 달려 있으며, 공지된 기술을 사용하여 당업자에 의해 확인 가능할 것이다 (예를 들어, Lloyd (1999) The Art, Science 및 Technology of Pharmaceutical Compounding 참조).
본원에서 사용된 바와 같이, 용어 "대상체"는 바이러스 감염과 같은 질환 또는 장애의 경감, 예방 및/또는 치료를 필요로 하는 동물, 바람직하게는 포유동물, 더 바람직하게는 인간을 말한다. 대상체는 인플루엔자 감염에 걸릴 수도 있거나 인플루엔자 바이러스 감염에 취약하다. "인플루엔자 바이러스 감염에 취약한" 대상체, 또는 "인플루엔자 바이러스 감염의 위험이 증가될 수도 있는" 대상체는 자가면역 질환으로 인해 손상된 면역계를 가진 상기 대상체, 면역 억제 요법을 받은 상기 사람 (예를 들어, 장기 이식 후), 백혈구 세포를 고갈시키거나 파괴하는 빈혈증의 특정 형태인 인간 면역 결핍 증후군 (HIV) 또는 후천성 면역 결핍 증후군 (AIDS)을 앓고 있는 상기 사람, 방사선 또는 화학요법을 받은 상기 사람, 또는 염증성 장애를 앓고 있는 상기 사람이다. 추가적으로, 극단적으로 어리거나 고령의 대상체는 위험이 증가된다. 감염된 개체와 육체적으로 접촉하거나 물리적으로 근접한 임의의 사람도 인플루엔자 바이러스에 감염될 위험이 증가된다. 더욱이, 대상체는 질환의 발병과의 근접함으로 인해, 예를 들어, 대상체는 인구 밀집 도시 또는 인플루엔자 바이러스에 감염된 것으로 확인되거나 의심되는 대상체와 가까이에 거주하기 때문에, 또는 직장의 선택, 예를 들어, 병원 근로자, 제약 연구원, 감염 지역의 여행자, 또는 상용 비행 고객으로 인해 인플루엔자에 감염될 위험이 있다.
본원에서 사용된 바와 같이, 용어 "치료하다", "치료하는", 또는 "치료"는 필요로 하는 대상체에게 본 발명의 항체와 같은 치료제의 투여로 인한 인플루엔자 감염의 적어도 하나의 증상 또는 징후의 심각도의 감소 또는 경감을 말한다. 용어는 질환의 진행 또는 감염의 악화의 억제를 포함한다. 용어는 또한 질환의 양성 예후를 포함하며, 즉, 대상체는 감염이 없을 수도 있거나 본 발명의 항체와 같은 치료제의 투여시 바이러스 역가가 감소되거나 없을 수도 있다. 치료제는 대상체에게 치료 용량으로 투여될 수도 있다.
용어 "예방하다", "예방하는" 또는 "예방"은 본 발명의 항체의 투여시 인플루엔자 감염의 발현 또는 인플루엔자 감염의 임의의 증상 또는 징후의 억제를 말한다. 용어는 바이러스에 노출되거나 인플루엔자 감염의 위험이 있는 대상체에서 감염의 확산의 예방을 포함한다.
본원에서 사용된 바와 같이 "보호 효과"는 항바이러스제와 같은 작용제, 또는 본 발명의 항-인플루엔자-HA 항체와 같은 항체가 다음 중 어느 하나 이상을 나타낼 수 있는지를 결정하기 위해서 업계에 공지된 임의의 표준 절차에 의해 나타날 수도 있다: 예를 들어, 감염원에 노출 이후 생존의 증가, 바이러스량의 감소, 또는 감염원과 관련된 적어도 하나의 증상의 경감.
본원에서 사용된 바와 같이, 용어 "항바이러스제"는 대상체에서 바이러스 감염을 치료, 예방, 또는 경감하는데 사용된 임의의 항감염제 또는 요법을 말한다. 용어 "항바이러스제"는 TAMIFLU® (오셀타미비르), RELENZA® (자나미비르), 리바비린, 또는 인터페론-알파2b를 포함하지만, 이에 제한되는 것은 아니다. 본 발명에서, 치료되는 감염은 인플루엔자 바이러스에 의해 유발된다.
일반적인 설명
인플루엔자는 오르토믹소비리대(Orthomyxoviridae) 과의 RNA 바이러스 (인플루엔자 바이러스)에 의해 유발되는 감염성 질환이다. 인플루엔자 바이러스는 코어 단백질을 기반으로 바이러스 외피 당단백질 헤마글루티닌 (HA) 및 뉴라미니다제 (NA)에 의해 결정되는 서브타입으로 더 나누어지는 세 개의 속 A, B 및 C으로 분류된다. 인플루엔자 A 바이러스는 포유류 및 조류 종의 범위를 감염시키는 반면에, B형 및 C형 감염은 대체로 인간으로 제한된다. A형 및 B형만이 임의의 우려하는 인간 질환을 유발한다.
인플루엔자 바이러스의 높은 돌연변이율 및 빈번한 유전자 재배열은 HA 및 NA 항원의 높은 가변성에 기여한다. 작은 변화 ("항원 변이")를 유발하는 소량의 점 돌연변이는 비교적 자주 발생한다. 항원 변이는 바이러스가 면역 인식을 피할 수 있게 하며, 유행기 사이의 기간 동안 반복된 인플루엔자 발병을 초래한다. HA 항원의 큰 변화 ("항원 변이")는 다른 인플루엔자 A 서브타입의 유전물질 재배열에 의해 유발된다. 새로운 유행성 균주를 발생시키는 항원 변이는 희귀한 사건이며, 동물 및 인간 서브타입 사이에서, 예를 들어, 동시-감염된 돼지에서 재배열을 통해 발생한다.
인플루엔자 A 바이러스에 대한 중화 항체 반응은 전형적으로 특정 바이러스 서브타입에 특이적이다. 18개의 인플루엔자 A 서브타입이 그것들의 헤마글루티닌 ("HA") 단백질에 의해 한정된다. 18개의 HA, H1-H18은 두 개의 군으로 분류될 수 있다. 1군은 H1, H2, H5, H6, H8, H9, H11, H12, H13, H16, H17 및 H18 서브타입으로 구성되고, 2군은 H3, H4, H7, H10, H14 및 H15 서브타입을 포함한다. 이러한 이유로 모든 인플루엔자 A 바이러스 서브타입, 뿐만 아니라 그것들의 매년의 변이체를 중화시킬 수 있는 광범위 중화 항체를 유도하는 백신을 갖는 것이 매우 바람직할 것이다. 이에 더하여 광범위 중화 헤테로서브타입 항체는 인플루엔자 A 감염의 예방 또는 치료용 의약으로서 투여될 수 있다.
HA는 호모-트리머 전구체 폴리펩타이드 HA0로서 합성된다. 각각의 모노머는 번역 후 독립적으로 절단되어 단일 이황화 결합으로 연결된 두 개의 폴리펩타이드, HA1 및 HA2를 형성할 수 있다. 더 큰 N-말단 단편 (HAL 320-330개의 아미노산)은 수용체-결합 부위 및 바이러스-중화 항체에 의해 인식되는 대부분의 결정요인을 함유하는 막-원위 구상 도메인을 형성한다. HA의 HA1 폴리펩타이드는 세포 표면으로 바이러스 부착의 원인이 된다. 더 작은 C-말단 부분 (HA2, 대략 180개의 아미노산)은 세포 또는 바이러스 막에 구상 도메인을 고정시키는 줄기-유사 구조를 형성한다. HA2 폴리펩타이드는 엔도솜에서 바이러스 및 세포 막의 융합을 매개하며, 세포질로의 리보핵산 단백질 복합체의 방출을 허용한다.
인플루엔자 A 바이러스의 하나 이상의 서브타입을 중화시키는 항체를 확인하는데 있어서 성공은 단지 제한적이었다. 또한, 지금까지 확인된 항체의 중화의 폭은 좁고 그 효능은 낮다. Okuno 등은 마우스를 인플루엔자 바이러스 A/Okuda/57 (H2N2)로 면역화하였고 HA2의 보존된 입체구조적 에피토프에 결합하여 동물 모델에서 시험관 내 및 생체 내에서 1군 H2, H1 및 H5 서브타입 인플루엔자 A 바이러스를 중화시키는 단클론성 항체를 분리하였다 (Okuno et al., J. Virol. 67:2552-8, 1993).
수십 년의 연구에도 불구하고, 인플루엔자 A 바이러스 감염을 광범위하게 중화시키거나 억제하거나 또는 인플루엔자 A 바이러스에 의해 유발된 질환을 약화시키는 항체는 판매되지 않고 있다. 그러므로, 인플루엔자 A 바이러스의 다수의 서브타입을 중화시키고 인플루엔자 A 감염의 예방 또는 치료용 의약으로서 사용될 수 있는 새로운 항체를 확인하는 것이 필요하다.
감염성 질환의 예방 또는 치료를 위한 수동적 면역요법은 한 세기 이상 동안 보통 높은 역가의 중화 항체를 함유하는 회복기 인간 혈청의 형태로 사용되었다 (Good et al. 1991; Cancer 68: 1415-1421). 최근에는, 다수의 정제된 단클론성 항체가 현재 항균제로서의 사용을 위해 전임상 및 임상 개발 중에 있다 (Marasco et al. 2007; Nature Biotechnology 25: 1421-1434).
발명자들은 본원에서 인플루엔자 헤마글루티닌에 특이적으로 결합하여 인플루엔자 바이러스와 숙주 세포의 상호작용을 조절하는 완전한 인간 항체 및 이것의 항원-결합 단편을 기술하였다. 항-인플루엔자 HA 항체는 높은 친화도로 인플루엔자 바이러스 HA에 결합할 수도 있다. 특정 구체예에서, 본 발명의 항체는 인플루엔자 HA에 결합하여 숙주 세포로의 바이러스 부착 및/또는 진입을 차단할 수도 있는 차단 항체이다. 일부 구체예에서, 본 발명의 차단 항체는 세포에 대한 인플루엔자 바이러스의 결합을 차단할 수도 있으며 이와 같이 숙주 세포의 바이러스 감염성을 억제하거나 중화시킬 수도 있다. 일부 구체예에서, 차단 항체는 인플루엔자 바이러스 감염으로 고통받는 대상체를 치료하는데 유용할 수도 있다. 항체는 필요로 하는 대상체에게 투여될 때 대상체에서 인플루엔자와 같은 바이러스에 의한 감염을 감소시킬 수도 있다. 그것들은 대상체 내 바이러스량을 감소시키는데 사용될 수도 있다. 그것들은 단독으로 또는 바이러스 감염을 치료하기 위해 업계에 공지된 다른 치료적 모이어티 또는 모달리티(modality)와 함께 부가 요법으로서 사용될 수도 있다. 특정 구체예에서, 이 항체들은 바이러스 HA의 줄기 영역에서 에피토프에 결합할 수도 있다. 또한, 확인된 항체는 포유동물을 감염으로부터 보호하기 위해 예방적으로 사용될 수 있거나 (감염 전), 또는 사전 확립된 감염을 경감하거나, 감염과 관련된 적어도 하나의 증상을 경감하기 위해 치료적으로 사용될 수 있다 (감염이 확립된 후).
전형적인 인플루엔자 HA의 전장 아미노산 서열은 GenBank에서 수탁 번호 HC483324.1로서 나타난다 (PCT 공보 WO2010/027818의 서열 번호: 62 참조).
특정 구체예에서, 본 발명의 항체는 제1 면역원, 예컨대 전장 인플루엔자 HA 또는 재조합 형태의 인플루엔자 HA 또는 이것의 단편으로 면역화된 후 이어서 제2 면역원, 또는 인플루엔자 HA의 면역원성 활성 단편으로 면역화된 마우스로부터 얻어진다. 특정 구체예에서, 항체는 인플루엔자 백신 조성물로 면역화된 후 이어서 하나 이상의 재조합으로 생산된 HA 펩타이드로 촉진 면역화된 마우스로부터 얻어진다.
면역원은 인플루엔자 HA의 생물학적 활성 및/또는 면역원성 단편 또는 그것의 활성 단편을 암호화하는 DNA일 수도 있다. 단편은 HA 단백질의 줄기 영역으로부터 유도될 수도 있다 (Sui et. al., Nature Struct. 및 Mol. Biol. Published online 22 Feb. 2009; Pages 1-9 참조).
펩타이드는 태깅(tagging)을 위해 또는 KLH와 같은 담체 분자로의 컨쥬게이션의 목적으로 특정 잔기의 추가 또는 치환을 포함하도록 변형될 수도 있다. 예를 들어, 시스테인이 펩타이드의 N 말단 또는 C 말단 단부에 추가될 수도 있거나, 또는 면역화를 위해, 예를 들어, KLH로의 컨쥬게이션을 위한 펩타이드를 제조하기 위해 링커 서열이 추가될 수도 있다.
본 발명의 특정 항-인플루엔자-HA 항체는 시험관 내 또는 생체 내 검정에 의해 결정된 바와 같이 인플루엔자-HA에 결합하여 인플루엔자-HA의 활성을 중화시킬 수 있다. 본 발명의 항체가 인플루엔자-HA에 결합하여 인플루엔자-HA의 활성 및 이런 식으로 숙주 세포에 부착 및/또는 진입에 이어서 뒤이은 바이러스 감염을 중화시키는 능력은 본원에서 기술된 바와 같이, 결합 검정, 또는 활성 검정을 포함한, 당업자들에게 공지되어 있는 임의의 표준 방법을 사용하여 측정될 수도 있다.
결합 활성을 측정하기 위한 비-제한적이고, 전형적인 시험관 내 검정은 본원에서, 실시예 3에서 예시된다. 실시예 3에서, 인플루엔자-HA에 대한 항-인플루엔자-HA 항체의 결합 친화도 및 해리 상수는 실시간 생체막 간섭계 기반 바이오센서에 의해 결정되었다 (Octet HTX 검정). 실시예 4 및 5에서, 중화 검정은 인플루엔자 바이러스의 다양한 1군 균주의 감염성을 결정하는데 사용되었다. 실시예 6에서, 특정 항체는 시험관 내 바이러스-감염된 세포의 보체 의존성 세포 독성 (CDC)을 매개하는 것으로 나타났다. 실시예 7 및 10은 본 발명의 특정 항체가 예방적으로 또는 치료적으로 투여될 때 생체 내에서 인플루엔자 A 감염을 중화시킬 수 있음을 나타낸다.
인플루엔자-HA에 특이적인 항체는 추가적인 라벨 또는 모이어티를 함유하지 않을 수도 있거나, N-말단 또는 C-말단 라벨 또는 모이어티를 함유할 수도 있다. 한 구체예에서, 라벨 또는 모이어티는 비오틴이다. 결합 검정에서, 라벨의 위치 (존재하면)는 펩타이드가 결합되는 표면에 대한 펩타이드의 배향을 결정할 수도 있다. 예를 들어, 표면이 아비딘으로 코팅되면, N-말단 비오틴을 함유하는 펩타이드는 펩타이드의 C-말단 부분이 표면에서 멀리 위치하도록 배향될 것이다. 한 구체예에서, 라벨은 방사성 핵종, 형광 염료 또는 MRI-검출 가능 라벨일 수도 있다. 특정 구체예에서, 이러한 라벨링된 항체는 이미지화 검정을 포함한 진단 검정에 사용될 수도 있다.
항체의 항원-결합 단편
달리 구체적으로 지시되지 않는 한, 용어 "항체"는, 본원에서 사용된 바와 같이, 두 개의 면역글로불린 중쇄 및 두 개의 면역글로불린 경쇄를 포함하는 항체 분자 (즉, "전체 항체 분자"), 뿐만 아니라 이것의 항원-결합 단편을 포함하는 것으로 이해되어야 한다. 용어 항체의 "항원-결합 부분", 항체의 "항원-결합 단편", 등은, 본원에서 사용된 바와 같이, 항원에 특이적으로 결합하여 복합체를 형성하는, 자연 발생하거나, 효소에 의해 획득 가능하거나, 합성되거나, 또는 유전적으로 조작된 임의의 폴리펩타이드 또는 당단백질을 포함한다. 용어 항체의 "항원-결합 단편", 또는 "항체 단편"은, 본원에서 사용된 바와 같이, 인플루엔자 HA에 특이적으로 결합하는 능력을 보유한 항체의 하나 이상의 단편을 말한다. 항체 단편은 Fab 단편, F(ab')2 단편, Fv 단편, dAb 단편, CDR 함유 단편, 또는 분리된 CDR을 포함할 수도 있다. 특정 구체예에서, 용어 "항원-결합 단편"은 다중-특이적 항원-결합 분자의 폴리펩타이드 단편을 말한다. 항체의 항원-결합 단편은, 예를 들어, 단백질 가수분해 소화 또는 항체 가변 및 (선택적으로는) 불변 도메인을 암호화하는 DNA의 조작 및 발현을 수반하는 재조합 유전적 조작 기술과 같은 임의의 적합한 표준 기술을 사용하여 전체 항체 분자로부터 유도될 수도 있다. 이러한 DNA는 공지되어 있고 및/또는, 예를 들어, 상업적 공급원, DNA 라이브러리 (예를 들어, 파지-항체 라이브러리 포함)로부터 쉽게 이용 가능하거나, 합성될 수 있다. DNA는, 예를 들어, 하나 이상의 가변 및/또는 불변 도메인을 적합한 배치로 배열하기 위해, 또는 코돈의 도입, 시스테인 잔기의 생성, 아미노산의 변형, 추가 또는 결실, 등을 위해 화학적으로 또는 분자 생물학적 기술을 사용하여 시퀀싱되고 조작될 수도 있다.
항원-결합 단편의 비-제한적 예는 (i) Fab 단편; (ii) F(ab')2 단편; (iii) Fd 단편; (iv) Fv 단편; (v) 단일-사슬 Fv (scFv) 분자; (vi) dAb 단편; 및 (vii) 항체의 초가변 영역을 모방하는 아미노산 잔기로 구성된 최소 인식 단위 (예를 들어, 분리된 상보성 결정 영역 (CDR), 예컨대 CDR3 펩타이드), 또는 제약된 FR3-CDR3-FR4 펩타이드를 포함한다. 도메인-특이적 항체, 단일 도메인 항체, 도메인-결실된 항체, 키메라 항체, CDR-이식된 항체, 디아바디, 트리아바디, 테트라바디, 미니바디, 나노바디 (예를 들어, 1가 나노바디, 2가 나노바디, 등), 소형 모듈 면역약제 (SMIP), 및 　상어 가변 IgNAR 도메인과 같은 다른 조작된 분자들은 또한 본원에서 사용된 바와 같이, 표현 "항원-결합 단편" 내에 포함된다.
항체의 항원-결합 단편은 전형적으로 적어도 하나의 가변 도메인을 포함할 것이다. 가변 도메인은 임의의 크기 또는 아미노산 조성의 것일 수도 있고 일반적으로 적어도 하나의 CDR을 포함할 것이며, 이것은 하나 이상의 프레임워크 서열에 인접하거나 상기 서열의 프레임 내에 있다. VL 도메인과 회합된 VH 도메인을 가지는 항원-결합 단편에서, VH 및 VL 도메인은 서로 임의의 적합한 배열로 위치할 수도 있다. 예를 들어, 가변 영역은 다이머이고 VH - VH, VH - VL 또는 VL - VL 다이머를 함유할 수도 있다. 대안으로, 항체의 항원-결합 단편은 모노머 VH 또는 VL 도메인을 함유할 수도 있다.
특정 구체예에서, 항체의 항원-결합 단편은 적어도 하나의 불변 도메인에 공유 결합에 의해 연결된 적어도 하나의 가변 도메인을 함유할 수도 있다. 본 발명의 항체의 항원-결합 단편 내에서 발견될 수도 있는 가변 및 불변 도메인의 비-제한적이고, 전형적인 배열은 다음을 포함한다: (i) VH -CH1; (ii) VH -CH2; (iii) VH -CH3; (iv) VH -CH1-CH2; (v) VH -CH1-CH2-CH3; (vi) VH -CH2-CH3; (vii) VH -CL; (viii) VL -CH1; (ix) VL -CH2; (x) VL -CH3; (xi) VL -CH1-CH2; (xii) VL -CH1-CH2-CH3; (xiii) VL -CH2-CH3; 및 (xiv) VL -CL. 상기 나열된 전형적인 배치 중 어느 것을 포함한 가변 및 불변 도메인의 임의의 배치에서, 가변 및 불변 도메인은 서로 직접적으로 연결될 수도 있거나 전체 또는 부분적인 힌지(hinge) 또는 링커 영역에 의해 연결될 수도 있다. 힌지 영역은 적어도 2개 (예를 들어, 5, 10, 15, 20, 40, 60개 이상)의 아미노산으로 구성될 수도 있으며, 이는 단일 폴리펩타이드 내 인접한 가변 및/또는 불변 도메인 사이에서 가요성 또는 반-가요성 연결을 초래한다. 더욱이, 본 발명의 항체의 항원-결합 단편은 서로 및/또는 하나 이상의 모노머 VH 또는 VL 도메인과 비-공유 회합된 (예를 들어, 이황화 결합(들)에 의해) 상기 나열된 가변 및 불변 도메인 배치 중 어느 것의 호모다이머 또는 헤테로다이머 (또는 다른 멀티머)를 포함할 수도 있다.
전체 항체 분자와 마찬가지로, 항원-결합 단편은 단일-특이적이거나 다중-특이적 (예를 들어, 이중-특이적)일 수도 있다. 항체의 다중-특이적 항원-결합 단편은 전형적으로 적어도 두 개의 다른 가변 도메인을 포함하며, 각각의 가변 도메인은 별도의 항원에 또는 같은 항원 상의 다른 에피토프에 특이적으로 결합할 수 있다. 본원에서 개시된 전형적인 이중-특이적 항체 포맷을 포함한 임의의 다중-특이적 항체 포맷은 본 발명의 항체의 항원-결합 단편의 맥락에서 사용을 위해 업계에서 이용 가능한 일상적인 기술을 사용하여 개조될 수도 있다.
인간 항체의 제조
트랜스제닉 마우스에서 인간 항체를 제조하는 방법은 업계에 공지되어 있다. 임의의 이러한 공지된 방법들은 본 발명의 맥락에서 인플루엔자-HA에 특이적으로 결합하는 인간 항체를 제조하는데 사용될 수 있다. 다음 중 어느 하나를 포함하는 면역원이 인플루엔자 HA에 대한 항체를 제조하는데 사용될 수 있다. 특정 구체예에서, 본 발명의 항체는 전장의 고유한 인플루엔자 HA (예를 들어, GenBank 수탁 번호 FJ966082.1 참조), 또는 생 약화된 또는 비활성화된 바이러스, 또는 단백질 또는 이것의 단편을 암호화하는 DNA로 면역화된 마우스로부터 획득된다. 대안으로, 인플루엔자-HA 단백질 또는 이것의 단편은 표준 생화학적 기술을 사용하여 생산되고 변형되어 면역원으로서 사용될 수도 있다. 한 구체예에서, 면역원은 재조합에 의해 생산된 인플루엔자-HA 단백질 또는 이것의 단편이다. 본 발명의 특정 구체예에서, 면역원은 인플루엔자 바이러스 백신일 수도 있다. 특정 구체예에서, 하나 이상의 촉진 주사액이 투여될 수도 있다. 특정 구체예에서, 촉진 주사액은 하나 이상의 인플루엔자 바이러스 균주, 또는 이 균주들로부터 유도된 헤마글루티닌을 포함할 수도 있으며, 예를 들어, Protein Sciences H1 A/New Caledonia/20/1999, H5 A/Indonesia/05/2005, H3 A/Victoria/361/2011, H7 A/Netherlands/219/2003, 또는 H9 A/Hong Kong/1073/1988을 참조하면 된다. 특정 구체예에서, 촉진 주사액은 인플루엔자 균주의 1:1 혼합물, 또는 상기 균주들로부터 유도된 헤마글루티닌의 1:1 혼합물을 함유할 수도 있다. 특정 구체예에서, 면역원은 대장균(E. coli) 또는 임의의 다른 진핵세포 또는 포유류 세포, 예컨대 중국 햄스터 난소 (CHO) 세포 또는 인플루엔자 바이러스 그 자체에서 발현된 재조합 인플루엔자 HA 펩타이드일 수도 있다.
VELOCIMMUNE® 기술 (예를 들어, US 6,596,541, Regeneron Pharmaceuticals, VELOCIMMUNE® 참조) 또는 단클론성 항체를 제조하기 위한 임의의 다른 공지된 방법을 사용하여, 인간 가변 영역 및 마우스 불변 영역을 가지는 인플루엔자-HA에 대한 고친화도 키메라 항체가 처음에 분리된다. VELOCIMMUNE® 기술은 마우스가 항원성 자극에 반응하여 인간 가변 영역 및 마우스 불변 영역을 포함하는 항체를 생산하도록 내인성 마우스 불변 영역 유전자좌에 작동 가능하게 연결된 인간 중쇄 및 경쇄 가변 영역을 포함하는 게놈을 가지는 트랜스제닉 마우스의 제조를 수반한다. 항체의 중쇄 및 경쇄의 가변 영역을 암호화하는 DNA는 분리되어 인간 중쇄 및 경쇄 불변 영역을 암호화하는 DNA에 작동 가능하게 연결된다. 이어서 DNA는 완전한 인간 항체를 발현할 수 있는 세포에서 발현된다.
일반적으로, VELOCIMMUNE® 마우스는 관심 있는 항원으로 공격접종되고, 림프 세포 (예컨대 B-세포)는 항체를 발현하는 마우스로부터 회수된다. 림프 세포는 림프 세포는 불멸의 하이브리도마(hybridoma) 세포주를 제조하기 위해 골수종(myeloma) 세포주와 융합될 수도 있고, 이러한 하이브리도마 세포주는 관심 있는 항원에 특이적인 항체를 생산하는 하이브리도마 세포주를 확인하기 위해 스크리닝되고 선택된다. 중쇄 및 경쇄의 가변 영역을 암호화하는 DNA는 분리되어 중쇄 및 경쇄의 바람직한 아이소타입 불변 영역에 연결될 수도 있다. 이러한 항체 단백질은 CHO 세포와 같은 세포에서 생산될 수도 있다. 대안으로, 항원-특이적 키메라 항체 또는 경쇄 및 중쇄의 가변 도메인을 암호화하는 DNA는 항원-특이적 림프구로부터 직접적으로 분리될 수도 있다.
처음에는, 인간 가변 영역 및 마우스 불변 영역을 가지는 고친화도 키메라 항체가 분리된다. 하기 실험 섹션에서와 같이, 항체가 특성화되고 친화도, 선택성, 에피토프, 등을 포함하는 바람직한 특징들에 대하여 선택된다. 마우스 불변 영역은 본 발명의 완전한 인간 항체, 예를 들어 야생형 또는 변형된 IgG1 또는 IgG4를 제조하기 위해 원하는 인간 불변 영역으로 대체된다. 선택된 불변 영역은 구체적인 용도에 따라 달라질 수도 있지만, 고친화도 항원-결합 및 표적 특이성 특징은 가변 영역에 있다.
생물학적 동등물
본 발명의 항-인플루엔자-HA 항체 및 항체 단편은 기술된 항체의 것들과 다르지만, 인플루엔자 HA에 결합하는 능력을 보유한 아미노산 서열을 가진 단백질을 포함한다. 이러한 변이체 항체 및 항체 단편은 모체 서열과 비교할 때 아미노산의 하나 이상의 추가, 결실, 또는 치환을 포함하지만, 기술된 항체와 본질적으로 동등한 생물학적 활성을 나타낸다. 유사하게, 본 발명의 항체-암호화 DNA 서열은 개시된 서열과 비교할 때 뉴클레오타이드의 하나 이상의 추가, 결실, 또는 치환을 포함하지만, 본 발명의 항체 또는 항체 단편에 대하여 본질적으로 생물학적으로 동등한 항체 또는 항체 단편을 암호화하는 서열을 포함한다.
두 개의 항원-결합 단백질, 또는 항체는, 예를 들어, 그것들이 흡수율 및 흡수의 정도가 유사한 실험 조건 하에 같은 몰 용량으로 1회 용량 또는 다회수 용량이 투여될 때 유의한 차이를 나타내지 않는 약학적 동등물 또는 약학적 대안인 경우 생물학적 동등물로 간주된다. 일부 항체는 그것들의 흡수의 정도는 동등하지만 그것들의 흡수율이 동등하지 않은 경우 동등물 또는 약학적 대안으로 간주되지만, 이러한 흡수율의 차이가 의도적이고 라벨링에 반영되며, 예를 들어, 만성적인 사용에 대하여 효과적인 신체 약물 농도의 달성에 필수적인 것이 아니고 연구되는 특정 약품에 대해서는 의학적으로 무의미한 것으로 간주되기 때문에 생물학적 동등물로 간주될 수도 있다.
한 구체예에서, 두 개의 항원-결합 단백질은 안전성, 순도, 또는 효능에 있어서 임상적으로 의미있는 차이가 없기 때문에 생물학적 동등물이다.
한 구체예에서, 두 개의 항원-결합 단백질은 스위칭이 없는 연속적 요법과 비교하여, 임상적으로 유의한 면역원성의 변화를 포함하는 예상된 부작용의 위험이 증가하지 않거나, 또는 유효성이 감소하지 않으면서 환자가 기준 제품 및 생물학 제품 사이에서 1회 이상 스위칭될 수 있는 경우 생물학적 동등물이다.
한 구체예에서, 두 개의 항원-결합 단백질은 그것들 둘 다가 사용 조건 또는 사용 조건들에 대하여 공통 메커니즘 또는 메커니즘들에 의해, 이러한 메커니즘이 알려져 있는 정도로, 작동하는 경우 생물학적 동등물이다.
생물학적 동등성은 생체 내 및/또는 시험관 내 방법에 의해 나타날 수도 있다. 생물학적 동등성 측정은, 예를 들어, (a) 인간 또는 다른 포유동물에서 생체 내 테스트 (여기에서, 항체 또는 그 대사산물의 농도는 시간의 함수로서 혈액, 혈장, 혈청, 또는 다른 생물학적 유동체에서 측정된다); (b) 인간 생체 내 생물학적 이용 가능성 데이터와 관련이 있으며 이것을 합리적으로 예측하는 시험관 내 테스트; (c) 항체 (또는 그것의 표적)의 적절한 급성 약물학적 효과가 시간의 함수로서 측정되는 인간 또는 다른 포유동물에서 생체 내 테스트; 및 (d) 항체의 안전성, 효험, 또는 생물학적 이용 가능성 또는 생물학적 동등성을 확립하는 잘 제어된 임상 시험을 포함한다.
본 발명의 항체의 생물학적으로 동등한 변이체는, 예를 들어, 잔기 또는 서열을 다양하게 치환시키거나 생물학적 활성에 필요하지 않은 말단 또는 내부 잔기 또는 서열을 결실시킴으로써 제조될 수도 있다. 예를 들어, 생물학적 활성에 필수적이지 않은 시스테인 잔기는 복원(renaturation) 시 불필요한 또는 부정확한 분자 내 이황화 브릿지(bridge)의 형성을 방지하기 위해 결실되거나 다른 아미노산으로 대체될 수 있다. 다른 맥락에서는, 생물학적 동등물 항체는 항체의 글리코실화 특징을 변형시키는 아미노산 변화를 포함하는 항체 변이체, 예를 들어, 글리코실화를 제거하거나 없애는 돌연변이를 포함할 수도 있다.
Fc 변이체를 포함하는 항-인플루엔자-HA 항체
본 발명의 특정 구체예에 따르면, 예를 들어, 중성 pH와 비교하여 산성 pH에서 FcRn 수용체로의 항체 결합을 향상시키거나 감소시키는 하나 이상의 돌연변이를 포함하는 Fc 도메인을 포함하는 항-인플루엔자-HA 항체가 제공된다. 예를 들어, 본 발명은 Fc 도메인의 CH2 또는 CH3 영역의 돌연변이를 포함하는 항-인플루엔자-HA 항체를 포함하며, 돌연변이(들)는 산성 환경에서 (예를 들어, ph가 약 5.5 내지 약 6.0의 범위에 있는 엔도솜에서) FcRn에 대한 Fc 도메인의 친화도를 증가시킨다. 이러한 돌연변이는 동물에게 투여될 때 항체의 혈청 반감기의 증가를 초래할 수도 있다. 이러한 Fc 변형의 비-제한적 예는, 예를 들어, 위치 250 (예를 들어, E 또는 Q); 250 및 428 (예를 들어, L 또는 F); 252 (예를 들어, L/Y/F/W 또는 T), 254 (예를 들어, S 또는 T), 및 256 (예를 들어, S/R/Q/E/D 또는 T)에서의 변형; 또는 위치 428 및/또는 433 (예를 들어, H/L/R/S/P/Q 또는 K) 및/또는 434 (예를 들어, A, W, H, F 또는 Y [N434A, N434W, N434H, N434F 또는 N434Y])에서의 변형; 또는 위치 250 및/또는 428에서의 변형; 또는 위치 307 또는 308 (예를 들어, 308F, V308F), 및 434에서의 변형을 포함한다. 한 구체예에서, 변형은 428L (예를 들어, M428L) 및 434S (예를 들어, N434S) 변형; 428L, 259I (예를 들어, V259I), 및 308F (예를 들어, V308F) 변형; 433K (예를 들어, H433K) 및 434 (예를 들어, 434Y) 변형; 252, 254, 및 256 (예를 들어, 252Y, 254T, 및 256E) 변형; 250Q 및 428L 변형 (예를 들어, T250Q 및 M428L); 및 307 및/또는 308 변형 (예를 들어, 308F 또는 308P)을 포함한다. 또 다른 구체예에서, 변형은 265A (예를 들어, D265A) 및/또는 297A (예를 들어, N297A) 변형을 포함한다.
예를 들어, 본 발명은 다음으로 구성된 군으로부터 선택된 돌연변이의 하나 이상의 쌍 또는 군을 포함하는 Fc 도메인을 포함하는 항-인플루엔자-HA 항체를 포함한다: 250Q 및 248L (예를 들어, T250Q 및 M248L); 252Y, 254T 및 256E (예를 들어, M252Y, S254T 및 T256E); 428L 및 434S (예를 들어, M428L 및 N434S); 257I 및 311I (예를 들어, P257I 및 Q311I); 257I 및 434H (예를 들어, P257I 및 N434H); 376V 및 434H (예를 들어, D376V 및 N434H); 307A, 380A 및 434A (예를 들어, T307A, E380A 및 N434A); 및 433K 및 434F (예를 들어, H433K 및 N434F). 상기 언급된 Fc 도메인 돌연변이 및 본원에서 개시된 항체 가변 도메인 내 다른 돌연변이의 모든 가능한 조합은 본 발명의 범위 내에 있는 것으로 고려된다.
본 발명은 또한 키메라 중쇄 불변 (CH) 영역을 포함하는 항-인플루엔자-HA 항체를 포함하며, 키메라 CH 영역은 하나 이상의 면역글로불린 아이소타입의 CH 영역으로부터 유도된 세그먼트를 포함한다. 예를 들어, 본 발명의 항체는 인간 IgG1, 인간 IgG2 또는 인간 IgG4 분자로부터 유도된 CH3 도메인의 일부 또는 모두와 조합된, 인간 IgG1, 인간 IgG2 또는 인간 IgG4 분자로부터 유도된 CH2 도메인의 일부 또는 모두를 포함하는 키메라 CH 영역을 포함할 수도 있다. 특정 구체예에 따르면, 본 발명의 항체는 키메라 힌지 영역을 가지는 키메라 CH 영역을 포함한다. 예를 들어, 키메라 힌지는 인간 IgG1, 인간 IgG2 또는 인간 IgG4 힌지 영역으로부터 유도된 "하부 힌지" 서열 (EU 넘버링(numbering)에 따르면 위치 228 내지 236의 아미노산 잔기)과 조합된, 인간 IgG1, 인간 IgG2 또는 인간 IgG4 힌지 영역으로부터 유도된 "상부 힌지" 아미노산 서열 (EU 넘버링에 따라 위치 216 내지 227의 아미노산 잔기)을 포함할 수도 있다. 특정 구체예에 따르면, 키메라 힌지 영역은 인간 IgG1 또는 인간 IgG4 상부 힌지로부터 유도된 아미노산 잔기 및 인간 IgG2 하부 힌지로부터 유도된 아미노산 잔기를 포함한다. 특정 구체예에서, 본원에서 기술된 바와 같이 키메라 CH 영역을 포함하는 항체는 항체의 치료적 또는 약동학적 성질에 부정적인 영향을 미치지 않으면서 변형된 Fc 효과기 기능을 나타낼 수도 있다 (예를 들어, 2013년 2월 1일에 출원된 미국 가출원 번호 제61/759,578호 참조).
항체의 생물학적 특징
일반적으로, 본 발명의 항체는 인플루엔자 HA에 결합함으로써 기능한다. 예를 들어, 본 발명은 실시간 생체막 간섭계 기반 바이오센서 (Octet HTX 검정), 또는 by 표면 플라스몬 공명에 의해 측정된 바와 같이, 10 nM 미만의 KD로 인플루엔자 HA에 결합하는 (예를 들어, 25℃ 또는 37℃에서) 항체 및 항체의 항원-결합 단편을 포함한다. 특정 구체예에서, 항체 또는 이것의 항원-결합 단편은, 예를 들어, 본원에서 기술된 검정 포맷, 또는 실질적으로 유사한 검정을 사용하여, 표면 플라스몬 공명에 의해 측정된 바와 같이, 약 5nM 미만, 약 2nM 미만, 약 1nM 미만, 약 500pM 미만, 250pM 미만, 또는 100pM 미만의 KD로 인플루엔자-HA에 결합한다.
본 발명은 또한, 예를 들어, 본원에서 한정된 검정 포맷, 또는 실질적으로 유사한 검정을 사용하여, 25℃에서 표면 플라스몬 공명에 의해 측정된 바와 같이 약 100분 초과의 해리 반감기 (t½)로 인플루엔자 HA에 결합하는 항체 및 이것들의 항원-결합 단편을 포함한다. 특정 구체예에서, 본 발명의 항체 또는 항원-결합 단편은, 예를 들어, 본원에서 한정된 검정 포맷 (예를 들어, mAb-캡쳐 또는 항원-캡쳐 포맷), 또는 실질적으로 유사한 검정을 사용하여, 25℃에서 표면 플라스몬 공명에 의해 측정된 바와 같이 약 200분 초과, 약 300분 초과, 약 400분 초과, 약 500분 초과, 약 600분 초과, 약 700분 초과, 약 800분 초과, 약 900분 초과, 또는 약 1000분 초과의 t½로 인플루엔자 HA에 결합한다. 한 구체예에서, 본 발명의 항체 및 항원-결합 단편은 300분 초과의 해리 반감기 (t½)로 인플루엔자 HA에 결합한다. 한 구체예에서, 본 발명의 항체는 원숭이 및 마우스에서 테스트될 때, Control I mAb로 지칭되는 비교기 항체와 비교하여 해리 반감기의 약 1.5 내지 2배 증가를 제공한다.
본 발명은 또한 숙주 세포에 대한 인플루엔자 바이러스의 감염성을 중화시키는 항체 또는 이것의 항원-결합 단편을 포함한다. 일부 구체예에서, 항체는 다양한 대표적인 1군 인플루엔자 바이러스 (H1N1 A/Puerto Rico/08/1934; H5N1 A/Vietnam/1203/2004; H1N1 A/California/07/2009; H1N1 A/Wisconsin/1933; H1N1 A/Brisbane/59/1997, H9N2 A/Hong Kong/33982/2009, H13N6 a/gull/Maryland/704/1977 및 H16N3 A/shorebird/Delaware/172/2006)에 대한 중화 효능을 나타내며, IC50은, 예를 들어, 실시예 4 및 5에서 도시된 바와 같이, 미세중화 검정, 또는 실질적으로 유사한 검정에서 약 1.6 nM 내지 약 130 nM의 범위에 있다. 한 구체예에서, 숙주 세포에 대한 인플루엔자 바이러스의 감염성을 중화시키는 항체 또는 이것의 항원-결합 단편은 상기 1군 인플루엔자 바이러스에 대한 중화 효능을 나타내며 IC50은 130 nM 미만이다.
본 발명은 또한 감염된 세포의 보체-의존성 세포 독성을 매개하는 항체 또는 이것의 항원-결합 단편을 포함하며, EC50은 약 20nM 내지 약 66nM의 범위에 있다 (실시예 6 참조). 한 구체예에서, 항체 또는 이것의 항원-결합 단편은 감염된 세포의 보체-의존성 세포 독성을 매개하며, EC50은 66 nM 미만이다.
본 발명은 또한 생체 내에서 인플루엔자 A 감염의 보호의 증가, 또는 강한 중화를 나타내는 항-인플루엔자-A HA 항체를 포함한다. 특정 항체는 예방적으로 (감염 전) 또는 치료적으로 (감염 후; 실시예 7 참조) 투여될 때 강한 중화를 나타낸다. 특정 구체예에서, 항체들 중 일부 (H1H11729P 및 H1H11829N2)는 1 mg/kg의 1회 용량으로서 예방적으로 투여될 때 마우스의 100% 생존을 나타냈다. 특정 항체는 0.5 mg/kg 정도의 용량으로 (H1H11729P로 지칭되는 항체를 사용하면 100% 생존), H1H11729P 0.1 mg/kg (40% 생존)으로, 또는 H1H11829N2 0.05 mg/kg (20% 생존)으로 예방적으로 투여될 때 마우스의 유의한 생존을 나타냈다. 전형적인 특정 항체 (H1H11829N2 및 H1H11729P)가 감염 후 15 또는 30 mg/kg의 용량으로 투여될 때 유의한 생존이 또한 관찰되었다. 한 구체예에서, 본 발명의 항체는 항바이러스제, 오셀타미비르와 조합될 때 인플루엔자-감염된 포유동물에서 추가적인 보호 효과를 나타낸다.
한 구체예에서, 본 발명은 인플루엔자 HA에 특이적으로 결합하는 분리된 재조합 항체 또는 이것의 항원-결합 단편을 제공하며, 항체 또는 이것의 단편은 다음 특징들 중 둘 이상을 나타낸다: (a) 완전한 인간 단클론성 항체이다; (b) 표면 플라스몬 공명 검정에서 측정된 바와 같이, 10-9M 미만의 해리 상수 (KD)로 인플루엔자 HA에 결합한다; (c) 약 370분 내지 1000분 초과의 범위에 있는 해리 반감기 (t½)를 나타낸다; (d) H1N1, H5N1, H9N2, H13N6 및 H16N3으로부터 선택된 1군 인플루엔자 A 바이러스의 중화를 나타내며, IC50은 약 1.6nM 내지 약 130nM의 범위에 있다; (e) 인플루엔자 바이러스 감염된 세포의 보체 매개 용해를 나타내며 EC50은 약 20nM 내지 약 66nM이다; 또는 (f) 바이러스 공격접종 이전 또는 이후 투여될 때 인플루엔자 바이러스 감염의 동물 모델에서 증가된 생존으로 측정된 바와 같이, 보호를 나타낸다.
본 발명의 항체는 상기 언급된 생물학적 특징들 중 둘 이상, 또는 이것들의 임의의 조합을 가지고 있을 수도 있다. 본 발명의 항체의 다른 생물학적 특징들은 본원의 작동예를 포함한 본 개시물의 재검토로부터 당업자에게 분명해 질 것이다.
에피토프 맵핑 및 관련 기술
본 발명은 인플루엔자 HA 분자의 하나 이상의 도메인 내에서 발견되는 하나 이상의 아미노산과 상호작용하는 항-인플루엔자-HA 바이러스 항체를 포함한다. 항체가 결합하는 에피토프는 인플루엔자 HA 분자 내에 위치한 3개 이상 (예를 들어, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20개 이상)의 아미노산의 단일 인접 서열로 구성될 수도 있다 (예를 들어, 도메인에서 선형 에피토프). 대안으로, 에피토프는 인플루엔자-HA 분자 내에 위치한 복수의 비-인접 아미노산 (또는 아미노산 서열)로 구성될 수도 있다 (예를 들어 입체구조적 에피토프).
당업자에게 공지되어 있는 다양한 기술들이 항체가 폴리펩타이드 또는 단백질 내에서 "하나 이상의 아미노산과 상호작용"하는지를 결정하는데 사용될 수 있다. 전형적인 기술들은, 예를 들어, 일상적인 교차-차단 검정, 예컨대 Antibodies, Harlow and Lane (Cold Spring Harbor Press, Cold Spring Harbor, NY)에서 기술된 것을 포함한다. 다른 방법들은 알라닌 스캐닝 돌연변이 분석, 펩타이드 블롯 분석 (Reineke (2004) Methods Mol. Biol. 248: 443-63), 펩타이드 절단 분석, 결정학적 연구 및 NMR 분석을 포함한다. 이에 더하여, 에피토프 적출, 에피토프 추출 및 항원의 화학적 변형과 같은 방법들이 이용될 수 있다 (Tomer (2000) Prot. Sci. 9: 487-496). 항체가 상호작용하는 폴리펩타이드 내에서 아미노산을 확인하는데 사용될 수 있는 또 다른 방법은 질량 분석법으로 검출되는 수소/중수소 교환이다. 일반적으로, 수소/중수소 교환 방법은 관심 있는 단백질을 중수소-라벨링한 후 이어서 중수소-라벨링된 단백질에 항체를 결합시키는 단계를 수반한다. 그 다음에, 단백질/항체 복합체는 물로 옮겨지고 항체 복합체에 의해 보호되는 아미노산 내에서 교환 가능한 양성자는 게면의 일부가 아닌 아미노산 내 교환 가능한 양성자보다 더 느린 속도로 중수소-대-수소 역교환을 거친다. 결과로서, 단백질/항체 계면의 일부를 형성하는 아미노산은 중수소를 보유할 수도 있으며 그러므로 계면에 포함되지 않은 아미노산과 비교하여 상대적으로 더 높은 질량을 나타낸다. 항체의 해리 후, 표적 단백질에 프로테아제 절단 및 질량 분석법이 실시되고, 이로 인해 항체가 상호작용하는 특이적 아미노산에 상응하는 중수소-라벨링된 잔기를 나타낸다. 예를 들어, Ehring (1999) Analytical Biochemistry 267: 252-259; Engen and Smith (2001) Anal. Chem. 73: 256A-265A 참조.
용어 "에피토프"는 B 및/또는 T 세포가 반응하는 항원 상의 부위를 말한다. B-세포 에피토프는 단백질의 3차 폴딩에 의해 병치된 인접 아미노산 또는 비인접 아미노산 둘 다로부터 형성될 수 있다. 인접 아미노산으로부터 형성된 에피토프는 전형적으로 변성 용매에 노출시 유지되는 반면에, 3차 폴딩(folding)에 의해 형성된 에피토프는 전형적으로 변성 용매의 처리시 손실된다. 에피토프는 전형적으로 독특한 공간적 입체구조로 적어도 3개, 및 더 일반적으로는, 적어도 5 또는 8-10개의 아미노산을 포함한다.
항원 구조-기반 항체 프로파일링 (Antigen Structure-based Antibody Profiling; ASAP)으로도 알려져 있는 변형-보조 프로파일링 (Modification-Assisted Profiling; MAP)은 화학적으로 또는 효소에 의해 변형된 항원 표면에 대한 각 항체의 결합 프로파일의 유사성에 따라 같은 항원을 향하는 다수의 단클론성 항체 (mAb)를 분류하는 방법이다 (US 2004/0101920 참조). 각각의 범주는 또 다른 범주로 표현되는 에피토프와 명백하게 다르거나 부분적으로 중첩되는 독특한 에피토프를 반영할 수도 있다. 이 기술은 특성화가 유전적으로 별개의 항체에 초점이 맞춰질 수 있도록 유전적으로 동일한 항체의 신속한 필터링을 허용한다. 하이브리도마 스크리닝에 적용될 때, MAP는 원하는 특징으로 가진 mAb를 생산하는 희귀한 하이브리도마 클론의 확인을 용이하게 할 수 있다. MAP는 본 발명의 항체를 다른 에피토프에 결합하는 항체의 군으로 분류하는데 사용될 수도 있다.
특정 구체예에서, 인플루엔자 바이러스-HA 항체 또는 이것의 항원-결합 단편은 자연적 형태의, 또는 재조합으로 생산된, 인플루엔자 HA에서 예시된 영역들 중 어느 하나 이상 내 에피토프, 또는 그 단편에 결합한다.
본 발명은 같은 에피토프, 또는 에피토프의 일부에 결합하는 항-인플루엔자-HA 항체를 포함한다. 유사하게, 본 발명은 또한 인플루엔자 HA 또는 이것의 단편으로의 결합에 대하여 본원에서 기술된 전형적인 특이적 항체 중 어느 것과 경쟁하는 항-인플루엔자-HA 항체를 포함한다. 예를 들어, 본 발명은 인플루엔자 HA로의 결합에 대하여 표 1 및 12에서 기술된 상기 항체들로부터 얻어진 하나 이상의 항체와 교차-경쟁하는 항-인플루엔자-HA 항체를 포함한다.
업계에 공지되어 있는 일상적인 방법을 사용하여 항체가 참조 항-인플루엔자-HA 항체와 같은 에피토프에 결합하거나, 또는 참조 항-인플루엔자-HA 항체와 결합에 대하여 경쟁하는지는 쉽게 결정될 수 있다. 예를 들어, 테스트 항체가 본 발명의 참조 항-인플루엔자-HA 항체와 같은 에피토프에 결합하는지를 결정하기 위해서, 참조 항체는 포화 조건 하에 인플루엔자 HA 또는 펩타이드에 결합하는 것이 허용된다. 그 다음에, 테스트 항체가 인플루엔자 HA 분자에 결합하는 능력이 평가된다. 테스트 항체가 참조 항-인플루엔자-HA 항체와 포화 결합 후 인플루엔자 바이러스 HA에 결합할 수 있는 경우, 테스트 항체는 참조 항-인플루엔자-HA 항체와 다른 에피토프에 결합하는 것으로 결론 내려질 수 있다. 다른 한편으로는, 테스트 항체가 참조 항-인플루엔자-HA 항체와 포화 결합 후 인플루엔자 HA에 결합할 수 없는 경우, 테스트 항체는 본 발명의 참조 항-인플루엔자-HA 항체에 의해 결합된 에피토프와 같은 에피토프에 결합할 수도 있다.
항체가 참조 항-인플루엔자-HA 항체와 결합에 대하여 경쟁하는지를 결정하기 위해서, 상기 기술된 결합 방법은 두 방향으로 수행된다: 제1 방향에서는, 참조 항체는 포화 조건 하에 인플루엔자 HA에 결합시킨 후 이어서 인플루엔자-HA 분자로의 테스트 항체의 결합을 평가한다. 제2 방향에서는, 테스트 항체는 포화 조건 하에 인플루엔자-HA 분자에 결합시킨 후 이어서 인플루엔자-HA 분자로의 참조 항체의 결합을 평가한다. 두 방향 모두에서, 제1 (포화) 항체만이 인플루엔자-HA 분자에 결합할 수 있는 경우, 테스트 항체 및 참조 항체는 인플루엔자-HA로의 결합에 대하여 경쟁하는 것으로 결론 내려진다. 당업자에 의해 이해될 수 있는 바와 같이, 참조 항체와 결합에 대하여 경쟁하는 항체는 반드시 참조 항체와 동일한 에피토프에 결합할 필요는 없지만, 중첩 또는 인접한 에피토프에 결합하여 참조 항체의 결합을 입체구조적으로 차단할 수도 있다.
두 항체는 각각 항원으로의 다른 것의 결합을 경쟁적으로 억제 (차단)하는 경우 같거나 중첩되는 에피토프에 결합한다. 즉, 한 항체의 1-, 5-, 10-, 20- 또는 100배 초과량은 경쟁적 결합 검정에서 측정된 바와 같이 다른 것의 결합을 적어도 50%, 하지만 바람직하게는 75%, 90% 또는 99%까지 억제한다 (예를 들어, Junghans et al., Cancer Res. 1990 50:1495-1502 참조). 대안으로, 한 항체의 결합을 감소시키거나 제거하는 항원 내의 본질적으로 모든 아미노산 돌연변이가 다른 것의 결합을 감소시키거나 제거하는 경우 두 항체는 같은 에피토프를 가진다. 한 항체의 결합을 감소시키거나 제거하는 일부 아미노산 돌연변이가 다른 것의 결합을 감소시키거나 제거하는 경우 두 항체는 중첩 에피토프를 가진다.
이어서 테스트 항체의 결합의 관찰된 결여가 실제로는 참조 항체와 같은 에피토프로의 결합으로 인한 것인지 또는 입체구조 차단 (또는 또 다른 현상)이 관찰된 결합의 결여의 원인인지를 확인하기 위해서 추가적인 일상적인 실험 (예를 들어, 펩타이드 돌연변이 및 결합 분석)이 수행된다. 이 부류의 실험들은 ELISA, RIA, 표면 플라스몬 공명, 유동 세포 분석법 또는 업계에서 이용 가능한 임의의 다른 정량적 또는 정성적 항체-결합 검정을 사용하여 수행될 수 있다.
면역컨쥬게이트
본 발명은 인플루엔자 바이러스 감염을 치료하기 위해서 변성독소 또는 항바이러스제와 같은 치료적 모이어티에 컨쥬게이션된 인간 항-인플루엔자-HA 단클론성 항체 ("면역컨쥬게이트")를 포함한다. 본원에서 사용된 바와 같이, 용어 "면역컨쥬게이트"는 방사능제, 사이토카인, 인터페론, 표적 또는 리포터 모이어티, 효소, 펩타이드 또는 단백질 또는 치료제에 화학적으로 또는 생물학적으로 연결된 항체를 말한다. 항체는 표적에 결합할 수 있는 한 분자를 따라 어떠한 위치에서도 방사능제, 사이토카인, 인터페론, 표적 또는 리포터 모이어티, 효소, 펩타이드 또는 치료제에 연결될 수도 있다. 면역컨쥬게이트의 예는 항체 약물 컨쥬게이트 및 항체-독소 융합 단백질을 포함한다. 한 구체예에서, 작용제는 인플루엔자-HA에 대한 제2 다른 항체일 수도 있다. 특정 구체예에서, 항체는 바이러스로 감염된 세포에 특이적인 작용제에 컨쥬게이션될 수도 있다. 항-인플루엔자-HA 항체에 컨쥬게이션될 수도 있는 치료적 모이어티의 유형은 처리되는 조건 및 달성되어야 하는 원하는 치료 효과를 고려할 것이다. 면역컨쥬게이트 형성에 적합한 작용제의 예는 업계에 공지되어 있다; 예를 들어, WO 05/103081 참조.
다중-특이적 항체
본 발명의 항체는 단일-특이적, 이중-특이적, 또는 다중-특이적일 수도 있다. 다중-특이적 항체는 하나의 표적 폴리펩타이드의 다른 에피토프에 특이적일 수도 있거나 하나 이상의 표적 폴리펩타이드에 특이적인 항원-결합 도메인을 함유할 수도 있다. 예를 들어, Tutt et al., 1991, J. Immunol. 147:60-69; Kufer et al., 2004, Trends Biotechnol. 22:238-244 참조.
본 발명의 다중-특이적 항원-결합 분자 중 어느 것, 또는 그 변이체는 당업자에게 공지된 바와 같이, 표준 분자 생물학 기술 (예를 들어, 재조합 DNA 및 단백질 발현 기술)을 사용하여 구성될 수도 있다.
일부 구체예에서, 인플루엔자-HA-특이적 항체는 인플루엔자 HA의 별개의 도메인에 결합하는 가변 영역이 단일 결합 분자 내에서 이중-도메인 특이성을 부여하도록 서로 연결되는 이중-특이적 포맷 ("이중-특이체")으로 생성된다. 적절하게 설계된 이중-특이체는 특이성 및 결합활성 둘 다를 증가시킴으로써 전체적인 인플루엔자-HA-단백질 억제 효험을 향상시킬 수도 있다. 개개의 도메인 (예를 들어, N-말단 도메인의 세그먼트)에 대한 특이성을 갖거나, 한 도메인 내 다른 영역에 결합할 수 있는 가변 영역은 각 영역을 별도의 에피토프, 또는 한 도메인 내 다른 영역에 동시에 결합시키는 구조적 스캐폴드(scaffold) 상에서 쌍을 형성한다. 이중-특이체에 대한 한 예에서, 한 도메인에 대한 특이성을 가지는 바인더의 중쇄 가변 영역 (VH)은 원래의 VH에 대한 원래의 특이성을 방해하지 않으면서 원래의 VH와 쌍을 형성할 수 있는 비-동족 VL 파트너를 확인하기 위해 제2 도메인에 대한 특이성을 가지는 일련의 바인더의 경쇄 가변 영역 (VL)과 재조합된다. 이렇게 하여, 단일 VL 세그먼트 (예를 들어, VL1)는 두 개의 결합 "아암(arm)"으로 구성된 이중-특이체 (VH1- VL1 및 VH2- VL1)를 생성하기 위해 두 개의 다른 VH 도메인 (예를 들어, VH1 및 VH2)과 조합될 수 있다. 단일 VL 세그먼트의 사용은 시스템의 복잡성을 감소시키고 이로 인해 이중-특이체를 생성하는데 사용된 클로닝, 발현, 및 정제 공정에서 효율을 증가시킨다 (예를 들어, USSN13/022759 및 US2010/0331527 참조).
대안으로, 하나 이상의 표적 및 제2 표적에 결합하는 항체, 예컨대, 제한되는 것은 아니지만, 예를 들어, 제2 다른 항-인플루엔자-HA 항체는 본원에서 기술된 기술, 또는 당업자에게 공지되어 있는 다른 기술을 사용하여 이중-특이적 포맷으로 제조될 수도 있다. 별개의 영역으로 결합하는 항체 가변 영역은 단일 결합 분자 내에서 이중-항원 특이성을 부여하기 위해, 예를 들어, 인플루엔자 바이러스 상의 적절한 부위에 결합하는 가변 영역과 연결될 수도 있다. 이러한 성질의 적절하게 설계된 이중-특이체는 이중 기능을 제공한다. 세포 외 도메인에 대한 특이성을 가지는 가변 영역은 세포 외 도메인 외부에 대한 특이성을 가지는 가변 영역과 조합되고 각각의 가변 영역을 별도의 항원에 결합시키는 구조적 스캐폴드 상에서 쌍을 형성한다.
본 발명의 맥락에서 사용될 수 있는 전형적인 이중-특이적 항체 포맷은 제1 면역글로불린 (Ig) CH3 도메인 및 제2 Ig CH3 도메인의 사용을 수반하며, 제1 및 제2 Ig CH3 도메인은 서로 적어도 하나의 아미노산이 다르고, 및 적어도 하나의 아미노산 차이는 아미노산 차이가 결여된 이중-특이적 항체와 비교하여 단백질 A로의 이중-특이적 항체의 결합을 감소시킨다. 한 구체예에서, 제1 Ig CH3 도메인은 단백질 A에 결합하고 제2 Ig CH3 도메인은 단백질 A 결합을 감소시키거나 폐지하는 돌연변이, 예컨대 H95R 변형 (IMGT 엑손 넘버링에 의해; EU 넘버링에 의해서는 H435R)을 함유한다. 제2 CH3은 Y96F 변형 (IMGT에 의해; EU에 의해서는 Y436F)을 더 포함할 수도 있다. 제2 CH3 내에서 발견될 수도 있는 추가의 변형은 다음을 포함한다: IgG1 항체의 경우에는 D16E, L18M, N44S, K52N, V57M, 및 V82I (IMGT에 의해; EU에 의해서는 D356E, L358M, N384S, K392N, V397M, 및 V422I); IgG2 항체의 경우에는 N44S, K52N, 및 V82I (IMGT; EU에 의해서는 N384S, K392N, 및 V422I); 및 IgG4 항체의 경우에는 Q15R, N44S, K52N, V57M, R69K, E79Q, 및 V82I (IMGT에 의해; EU에 의해서는 Q355R, N384S, K392N, V397M, R409K, E419Q, 및 V422I). 상기 기술된 이중-특이적 항체 포맷의 변화는 본 발명의 범위 내에 있는 것으로 고려된다.
본 발명의 맥락에서 사용될 수 있는 다른 전형적인 이중 특이적 포맷은, 제한이 아니라, 예를 들어, scFv-기반 또는 디아바디 이중 특이적 포맷, IgG-scFv 융합, 이중 가변 도메인 (DVD)-Ig, 콰드로마(Quadroma), 놉-인투-홀(knob-into-hole), 공통 경쇄 (예를 들어, 놉-인투-홀을 가지는 공통 경쇄, 등), CrossMab, CrossFab, (SEED)body, 류신 지퍼(zipper), 듀오바디, IgG1/IgG2, 이중 작용 Fab (DAF)-IgG, 및 Mab2 이중 특이적 포맷 (예를 들어, 상기 언급된 포맷의 재검토를 위해 Klein et al. 2012, mAbs 4:6, 1-11, 및 본원에서 인용된 참조문헌 참조)을 포함한다. 이중 특이적 항체는 또한 펩타이드/핵산 컨쥬게이션을 사용하여 구성될 수 있으며, 예를 들어, 직각 화학 반응성을 가진 비천연 아미노산은 한정된 조성, 원자가 및 기하학적 구조를 가지는 멀티머 복합체로 자가-조립되는 부위-특이적 항체-올리고뉴클레오타이드 컨쥬게이트를 생성하는데 사용된다 (예를 들어, Kazane et al., J. Am. Chem . Soc. [Epub: Dec . 4, 2012]).
치료적 투여 및 제형
본 발명은 본 발명의 항-인플루엔자-HA 항체 또는 이것의 항원-결합 단편을 포함하는 치료적 조성물을 제공한다. 본 발명에 따르는 치료적 조성물은 적합한 담체, 부형제, 및 개선된 이동, 전달, 내성, 등을 제공하기 위해 제형에 포함되는 다른 작용제와 함께 투여될 것이다. 모든 약사들에게 공지되어 있는 처방집: Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, PA에서 다수의 적절한 제형이 발견될 수 있다. 이 제형들은, 예를 들어, 분말, 페이스트, 연고, 젤리, 왁스, 오일, 지질, 소포를 함유하는 지질 (양이온성 또는 음이온성) (예컨대 LIPOFECTIN™), DNA 컨쥬게이트, 무수 흡수 페이스트, 수중유(oil-in-water) 및 유중수(water-in-oil) 에멀젼, 에멀젼 카보왁스 (다양한 분자량의 폴리에틸렌 글리콜), 반고체 겔, 및 카보왁스를 함유하는 반고체 혼합물을 포함한다. Powell et al. "Compendium of excipients for parenteral formulations" PDA (1998) J Pharm Sci Technol 52:238-311 참조.
항체의 용량은 투여되는 대상체의 나이 및 크기, 표적 질환, 상태, 투여 경로, 등에 따라 달라질 수도 있다. 본 발명의 항체가 성인 환자의 질환 또는 장애를 치료하거나, 또는 이러한 질환을 예방하는데 사용될 때, 보통 약 0.1 내지 약 60 mg/kg 체중, 더 바람직하게는 약 5 내지 약 60, 약 10 내지 약 50, 또는 약 20 내지 약 50 mg/kg 체중의 1회 용량으로 본 발명의 항체를 투여하는 것이 유리하다. 상태의 심각도에 따라, 치료의 빈도 및 기간이 조정될 수 있다. 특정 구체예에서, 본 발명의 항체 또는 이것의 항원-결합 단편은 적어도 약 0.1 mg 내지 약 5000 mg, 약 1 내지 약 2000 mg, 약 5 내지 약 1000 mg, 또는 약 10 내지 약 500 mg, 내지 약 100 mg, 또는 내지 약 50 mg의 초기 용량으로 투여될 수 있다. 특정 구체예에서, 초기 용량 이후에는 초기 용량과 거의 같거나 더 적은 양으로 항체 또는 이것의 항원-결합 단편의 2차 또는 복수의 후속 용량의 투여가 이어지며, 후속 투여는 적어도 1일 내지 3일; 적어도 1주, 적어도 2주; 적어도 3주; 적어도 4주; 적어도 5주; 적어도 6주; 적어도 7주; 적어도 8주; 적어도 9주; 적어도 10주; 적어도 12주; 또는 적어도 14주 간격으로 분리된다.
다양한 전달 시스템, 예를 들어, 리포솜의 캡슐화, 미세입자, 미세캡슐, 돌연변이 바이러스를 발현할 수 있는 재조합 세포, 수용체 매개 엔도사이토시스(endocytosis)가 공지되어 있으며 본 발명의 약학적 조성물을 투여하는데 사용될 수 있다 (예를 들어, Wu et al. (1987) J. Biol. Chem. 262:4429-4432 참조). 도입 방법은 피내, 경피, 근육 내, 복강 내, 정맥 내, 피하, 비강 내, 경막 외 및 구강 경로를 포함하지만, 이에 제한되는 것은 아니다. 조성물은 임의의 편리한 경로, 예를 들어, 주입 또는 볼루스(bolus) 주사, 상피 또는 점막피부 라이닝(lining) (예를 들어, 구강 점막, 직장 및 장 점막, 등)을 통한 흡수에 의해 투여될 수도 있고, 생물학적 활성제와 함께 투여될 수도 있다. 투여는 전신적 또는 국소적일 수 있다. 약학적 조성물은 또한 소포, 특히 리포솜에서 전달될 수 있다 (예를 들어, Langer (1990) Science 249:1527-1533 참조).
본 발명의 항체를 전달하기 위한 나노입자의 사용이 또한 본원에서 고려된다. 항체-컨쥬게이션된 나노입자는 치료 및 진단 용도 둘 다로 사용될 수도 있다. 항체-컨쥬게이션된 나노입자와 제조 및 사용 방법은 Arruebo, M., et al. 2009 ("Antibody-conjugated nanoparticles for biomedical applications" in J. Nanomat. Volume 2009, Article ID 439389, 24 pages, doi: 10.1155/2009/439389)에 의해 상세히 기술되며, 본원에 참조로 포함된다. 나노입자는 바이러스로 감염된 세포를 표적화하기 위해 개발되고 약학적 조성물에 함유된 항체에 컨쥬게이션될 수도 있다. 약물 전달용 나노입자는 또한, 예를 들어, US 8257740, 또는 US 8246995에서 기술되었으며, 각각 그 전문이 본원에 포함된다.
특정 상황에서, 약학적 조성물은 제어된 방출 시스템에서 전달될 수 있다. 한 구체예에서, 펌프가 사용될 수도 있다. 또 다른 구체예에서, 폴리머 물질이 사용될 수도 있다. 또 다른 구체예에서, 제어된 방출 시스템은 조성물의 표적과 가까이에 배치될 수 있으며, 따라서 전신 용량의 일부만이 필요하다.
주사 가능한 조제물은 정맥 내, 피하, 피부 내, 두개 내, 복강 내 및 근육 내 주사, 점적 주입, 등을 위한 투약 형태를 포함할 수도 있다. 이 주사 가능한 조제물들은 공개적으로 알려져 있는 방법에 의해 제조될 수도 있다. 예를 들어, 주사 가능한 조제물은 예를 들어, 상기 기술된 항체 또는 그것의 염을 통상적으로 주사에 사용되는 멸균 수성 매질 또는 유성 매질에서 용해, 현탁 또는 에멀젼화시킴으로써 제조될 수도 있다. 주사용 수성 매질로서, 예를 들어, 생리 식염수, 글루코스 및 다른 보제를 함유하는 등장성 용액, 등이 있으며, 이것들은 적절한 가용화제, 예컨대 알콜 (예를 들어, 에탄올), 다가 알콜 (예를 들어, 프로필렌 글리콜, 폴리에틸렌 글리콜), 비이온성 계면활성제 [예를 들어, 폴리소르베이트 80, HCO-50 (수소 첨가된 피마자 오일의 폴리옥시에틸렌 (50 mol) 부가물)], 등과 조합하여 사용될 수 있다. 유성 매질로서, 예를 들어, 참깨 오일, 대두 오일, 등이 이용되며, 이것들은 벤질 벤조에이트, 벤질 알콜, 등과 같은 가용화제와 조합하여 사용될 수도 있다. 이렇게 하여 제조된 주사액은 바람직하게는 적절한 앰플에 채워진다.
본 발명의 약학적 조성물은 표준 바늘 및 주사기를 이용하여 피하로 또는 정맥 내로 전달될 수 있다. 이에 더하여, 피하 전달에 대하여, 펜 전달 디바이스가 본 발명의 약학적 조성물을 전달하는데 쉽게 적용된다. 이러한 펜 전달 디바이스는 재사용 가능하거나 1회용일 수 있다. 재사용 가능한 펜 전달 디바이스는 일반적으로 약학적 조성물을 함유한 대체 가능한 카트리지를 활용한다. 카트리지 내 모든 약학적 조성물이 투여되어 카트리지가 비게 되면, 빈 카트리지는 쉽게 폐기되고 약학적 조성물을 함유한 새로운 카트리지로 대체될 수 있다. 그 다음에 펜 전달 디바이스가 재사용될 수 있다. 1회용 펜 전달 디바이스에서는, 대체 가능한 카트리지가 없다. 대신에, 1회용 펜 전달 디바이스는 디바이스 내부의 레저버에 담겨있는 약학적 조성물로 미리 채워진다. 레저버에 약학적 조성물이 비워지면, 전체 디바이스가 폐기된다.
많은 재사용 가능한 펜 및 자동 주사기 전달 디바이스는 본 발명의 약학적 조성물의 피하 전달에 적용된다. 예는 단지 몇 가지 예를 들자면, AUTOPEN™ (Owen Mumford, Inc., Woodstock, UK), DISETRONIC™ 펜 (Disetronic Medical Systems, Burghdorf, Switzerland), HUMALOG MIX 75/25™ 펜, HUMALOG™ 펜, HUMALIN 70/30™ 펜 (Eli Lilly and Co., Indianapolis, IN), NOVOPEN™ I, II 및 III (Novo Nordisk, Copenhagen, Denmark), NOVOPEN JUNIOR™ (Novo Nordisk, Copenhagen, Denmark), BD™ 펜 (Becton Dickinson, Franklin Lakes, NJ), OPTIPEN™, OPTIPEN PRO™, OPTIPEN STARLET™, 및 OPTICLIK™ (Sanofi-Aventis, Frankfurt, Germany)을 포함하지만, 확실하게 이것들에 제한되는 것은 아니다. 본 발명의 약학적 조성물의 피하 전달에 적용되는 1회용 펜 전달 디바이스의 예는 단지 몇 가지 예를 들자면, SOLOSTAR™ 펜 (Sanofi-Aventis), FLEXPEN™ (Novo Nordisk), 및 KWIKPEN™ (Eli Lilly), SURECLICK ™ 자동 주사기 (Amgen, Thousand Oaks, CA), PENLET ™ (Haselmeier, Stuttgart, Germany), EPIPEN (Dey, L.P.) 및 HUMIRA ™ 펜 (Abbott Labs, Abbott Park, IL)을 포함하지만, 확실하게 이것들에 제한되는 것은 아니다.
유리하게는, 상기 기술된 경구 또는 비경구 사용을 위한 약학적 조성물은 활성 성분의 용량에 맞게 적합한 단위 용량의 투약 형태로 제조된다. 단위 용량의 이러한 투약 형태는, 예를 들어, 타블렛, 알약, 캡슐, 주사액 (앰플), 좌제, 등을 포함한다. 함유된 항체의 양은 일반적으로 단위 용량의 투약 형태 당 약 5 내지 약 5000 mg이며; 특히 주사 형태에서는, 항체는 다른 투약 형태에 대하여 약 5 내지 약 500 mg 및 약 10 내지 약 250 mg으로 함유되는 것이 바람직하다.
항체의 치료적 사용
본 발명의 항체는 인플루엔자 바이러스 감염과 관련된 질환 또는 장애 또는 상태의 치료, 및/또는 예방 및/또는 이러한 질환, 장애 또는 상태와 관련된 하나의 증상의 경감에 유용하다.
특정 구체예에서, 본 발명의 항체는 인플루엔자 바이러스에 의해 유발된 중증 및 급성 호흡기 감염으로 고통받고 있는 대상체를 치료하는데 유용하다. 일부 구체예에서, 본 발명의 항체는 숙주에서 바이러스 역가를 감소시키거나 바이러스량을 감소시키는데 유용하다. 한 구체예에서, 본 발명의 항체 또는 이것의 항원-결합 단편은 인플루엔자 바이러스 감염된 환자에게 치료 용량으로 투여될 수도 있다.
본 발명의 하나 이상의 항체는 질환 또는 장애의 증상 또는 상태 중 하나 이상을 완화 또는 예방하거나 또는 그것들의 심각도를 감소시키기 위해 투여될 수도 있다. 항체는 제한되는 것은 아니지만, 열, 기침, 인후염, 두통, 근육통, 피로, 극도의 고갈, 숨가쁨, 기관지염, 폐렴, 및 사망을 포함하는, 인플루엔자 바이러스 감염의 적어도 하나의 증상의 심각도를 경감하거나 감소시키는데 사용될 수도 있다.
또한 본원에서는 인플루엔자 바이러스에 감염될 위험이 있는 대상체, 예컨대 면역 손상된 개체, 고령의 성인 (65살 초과), 2살 미만의 아동, 의료계 종사자, 인플루엔자 바이러스 감염으로 고통받고 있는 환자 가까이에 있는 가족 구성원, 및 병력이 있는 환자 (예를 들어, 폐 감염, 심장 질환 또는 당뇨병의 위험이 증가됨)에게 본 발명의 하나 이상의 항체를 예방적으로 사용하는 것이 고려된다.
본 발명의 추가의 구체예에서, 본 항체는 인플루엔자 바이러스 감염으로 고통받고 있는 환자를 치료하기 위한 약학적 조성물의 제조에 사용된다. 본 발명의 또 다른 구체예에서, 본 항체는 부가 요법으로서 인플루엔자 바이러스 감염을 치료하거나 경감하는데 유용한, 당업자에게 공지되어 있는 임의의 다른 작용제 또는 임의의 다른 요법과 함께 사용된다.
조합 요법
조합 요법은 본 발명의 항-인플루엔자-HA 항체 및 본 발명의 항체, 또는 본 발명의 항체의 생물학적 활성 단편과 유리하게 조합될 수도 있는 임의의 추가적인 치료제를 포함할 수도 있다. 본 발명의 항체는 인플루엔자 바이러스를 치료하는데 사용되는 하나 이상의 약물 또는 작용제 (예를 들어, 항바이러스제)와 상승 작용을 하면서 조합될 수도 있다.
예를 들어, 전형적인 항바이러스제는, 예를 들어, 백신, 뉴라미니다제 억제자 또는 뉴클레오사이드 유사체를 포함한다. 본 발명의 항체와 조합하여 사용될 수도 있는 다른 전형적인 항바이러스제는, 예를 들어, 지도부딘, 갱사이클로비르, 비다라빈, 이독수리딘, 트리플루리딘, 포스카르네트, 아사이클로비르, 리바비린, 아만타딘, 레만티딘, 사퀴나비르, 인디나비르, 리토나비르, 알파-인터페론 및 다른 인터페론, 뉴라미니다제 억제자 (예를 들어, 자나미비르 (RELENZA®), 오셀타미비르 (TAMIFLU®), 라니나미비르, 페라미비르), 또는 리만타딘을 포함할 수 있다.
다른 전형적인 항바이러스제는 HA 억제자, 시알산 억제자 및 M2 이온 채널 억제자를 포함하지만, 이에 제한되는 것은 아니다. 한 구체예에서, M2 이온 채널 억제자는 아만타딘 또는 리만타딘이다.
일부 구체예에서, 본 발명의 항체는 인플루엔자 바이러스 감염된 환자에서 바이러스량을 감소시키거나, 또는 감염의 하나 이상의 증상을 경감하기 위해 제2 치료제와 조합될 수도 있다.
본 발명의 항체는 인플루엔자 바이러스 감염을 치료하기 위해 항염증제 (예를 들어, 코르티코스테로이드, 및 비-스테로이드성 항염증제), 충혈완화제, 항히스타민제, 항감염제, 인플루엔자 바이러스에 대한 다른 항체, 항바이러스제, 인플루엔자 바이러스에 대한 백신, 예컨대 FLUMIST® 또는 FLUVIRIN®, 식이보충제, 예컨대 항산화제 또는 임의의 다른 완화 요법과 조합하여 사용될 수도 있다.
특정 구체예에서, 제2 치료제는 인플루엔자에 대한 또 다른 항체이다. 특정 구체예에서, 제2 치료제는 인플루엔자 헤마글루티닌에 대한 또 다른 항체이다. 특정 구체예에서, 제2 치료제는 다른 인플루엔자 단백질, 예컨대 뉴라미니다제, 또는 매트릭스 단백질 2 (M2e 단백질)의 테트라머 엑토도메인에 대한 또 다른 항체이다. 특정 구체예에서, 제2 치료제는 다른 단백질, 예컨대 숙주 막관통 프로테아제, 세린 2 (TMPRSS2)에 대한 항체이다. 제2 항체는 바이러스의 다른 서브타입 또는 균주의 하나 이상의 다른 인플루엔자 바이러스 단백질에 특이적일 수도 있다. 본원에서는 인플루엔자 바이러스에 대한 광범위 중화 또는 억제 활성을 가지는 항체의 조합 ("칵테일")을 사용하는 것이 고려된다. 일부 구체예에서, 비-경쟁 항체는 선택압의 결과로서 신속한 돌연변이로 인해 인플루엔자 바이러스가 탈출하는 능력을 감소시키기 위해 조합되고 필요로 하는 대상체에게 투여될 수도 있다. 일부 구체예에서, 조합을 포함하는 항체는 HA 단백질 상의 별개의 비-중첩 에피토프에 결합한다. 조합을 포함하는 항체는 숙주 세포로의 바이러스 부착 및/또는 진입 및/또는 숙주 세포와의 융합을 차단할 수도 있다. 항체는 H1, H2, H5, H6, H8, H9, H11, H12, H13, H16, H17 또는 H18을 포함하는 1군 인플루엔자 A 서브타입 중 임의의 하나 이상으로부터 선택된 헤마글루티닌과 상호작용할 수도 있고 단독으로, 또는 상기 언급된 작용제들 중 임의의 하나 이상과 조합하여 사용될 때, 제한되는 것이 아니라, H1N1, H5N1, H9N2, H13N6 및 H16N3을 포함하는 1군 인플루엔자 서브타입 중 임의의 하나 이상을 중화할 수도 있다.
또한 본원에서는 본 발명의 항-인플루엔자-HA 항체의 조합을 사용하는 것이 고려되며, 조합은 교차-경쟁하지 않는 하나 이상의 항체를 포함하고; 일부 구체예에서, 조합은 광범위 중화 활성을 가지는 제1 항체와 분리체의 좁은 스펙트럼에 대한 활성을 가지고 제1 항체와 교차-경쟁하지 않는 제2 항체를 포함한다.
본원에서 사용된 바와 같이, 용어 "~와 조합하여"는 추가적인 치료적 활성 구성요소(들)가 본 발명의 항-인플루엔자-HA 항체의 투여 이전에, 투여와 동시에, 투여 이후에 투여될 수 있음을 의미한다. 용어 "~와 조합하여"는 또한 항-인플루엔자-HA 항체 및 제2 치료제의 순차적인 또는 부수적인 투여를 포함한다.
추가적인 치료적 활성 구성요소(들)는 본 발명의 항-인플루엔자-HA 항체의 투여 이전에 대상체에게 투여될 수도 있다. 예를 들어, 제1 구성요소가 제2 구성요소의 투여 1주 전, 72시간 전, 60시간 전, 48시간 전, 36시간 전, 24시간 전, 12시간 전, 6시간 전, 5시간 전, 4시간 전, 3시간 전, 2시간 전, 1시간 전, 30분 전, 15분 전, 10분 전, 5분 전, 또는 1분 미만 전에 투여되는 경우, 제1 구성요소는 제2 구성요소 "이전에" 투여되는 것으로 간주될 수도 있다. 다른 구체예에서, 추가적인 치료적 활성 구성요소(들)는 본 발명의 항-인플루엔자-HA 항체의 투여 이후에 대상체에게 투여될 수도 있다. 예를 들어, 제1 구성요소가 제2 구성요소의 투여 1분 후, 5분 후, 10분 후, 15분 후, 30분 후, 1시간 후, 2시간 후, 3시간 후, 4시간 후, 5시간 후, 6시간 후, 12시간 후, 24시간 후, 36시간 후, 48시간 후, 60시간 후, 72시간 후에 투여되는 경우, 제1 구성요소는 제2 구성요소 "이후에" 투여되는 것으로 간주될 수도 있다. 다른 구체예에서, 추가적인 치료적 활성 구성요소(들)는 본 발명의 항-인플루엔자-HA 항체의 투여와 동시에 대상체에게 투여될 수도 있다. "동시" 투여는, 본 발명의 목적을 위해서, 예를 들어, 대상체에게 단일 투약 형태로, 또는 서로 30분 이하 이내에 대상체에게 투여되는 별도의 투약 형태로 항-인플루엔자-HA 항체 및 추가적인 치료적 활성 구성요소의 투여를 포함한다. 별도의 투약 형태로 투여되는 경우, 각각의 투약 형태는 같은 경로를 통해 투여될 수도 있다 (예를 들어, 항-인플루엔자-HA 항체 및 추가적인 치료적 활성 구성요소 둘 다는 정맥 내, 등으로 투여될 수도 있다); 대안으로, 각각의 투약 형태는 다른 경로를 통해 투여될 수도 있다 (예를 들어, 항-인플루엔자-HA 항체는 정맥 내로 투여될 수도 있고, 추가적인 치료적 활성 구성요소는 경구로 투여될 수도 있다). 어떠한 경우에도, 단일 투약 형태, 같은 경로에 의한 별도의 투약 형태, 또는 다른 경로에 의한 별도의 투약 형태로 구성요소를 투여하는 것은 모두, 본 개시물의 목적을 위해서, "동시 투여"로 간주된다. 본 개시물의 목적을 위해서, 추가적인 치료적 활성 구성요소의 투여 "이전에", 투여와 "동시에", 또는 투여 "이후에" (상기 용어들이 본원에서 상기 한정된 바와 같다) 항-인플루엔자-HA 항체의 투여는 추가적인 치료적 활성 구성요소와 "조합하여" 항-인플루엔자-HA 항체의 투여로 간주된다.
본 발명은 본원에서 다른 곳에서도 기술된 바와 같이 본 발명의 항- 인플루엔자-HA 항체가 추가적인 치료적 활성 구성요소(들) 중 하나 이상과 동시-제형화된 약학적 조성물을 포함한다.
투여 양생법
특정 구체예에 따르면, a single dose of an
본 발명의 항-인플루엔자-HA 항체 (또는 항-인플루엔자-HA 항체 및 본원에서 언급된 추가적인 치료적 활성 작용제 중 어느 것의 조합을 포함하는 약학적 조성물)의 1회 용량이 필요로 하는 대상체에게 투여될 수도 있다. 본 발명의 특정 구체예에 따르면, 항-인플루엔자-HA 항체 (또는 항-인플루엔자-HA 항체 및 본원에서 언급된 추가적인 치료적 활성 작용제 중 어느 것의 조합을 포함하는 약학적 조성물)의 다회수 용량이 한정된 시간 과정에 걸쳐 대상체에게 투여될 수도 있다. 본 발명의 이 양태에 따르는 방법은 본 발명의 항-인플루엔자-HA 항체의 다회수 용량을 대상체에게 순차적으로 투여하는 단계를 포함한다. 본원에서 사용된 바와 같이, "순차적으로 투여하는 단계"는 항-인플루엔자-HA 항체의 각각의 용량이 다른 시점에, 예를 들어, 사전 결정된 간격 (예를 들어, 시간, 일, 주 또는 월)으로 분리된 다른 날에 대상체에게 투여됨을 의미한다. 본 발명은 항-인플루엔자-HA 항체의 1회 초기 용량에 이어서, 항-인플루엔자-HA 항체의 1회 이상의 2차 용량에 이어서, 선택적으로 항-인플루엔자-HA 항체의 1회 이상의 3차 용량을 환자에게 순차적으로 투여하는 단계를 포함하는 방법을 포함한다.
용어 "초기 용량", "2차 용량", 및 "3차 용량"은 본 발명의 항-인플루엔자-HA 항체의 투여의 시간 순서를 말한다. 따라서, "초기 용량"은 치료 양생법의 시작시 투여되는 용량이고 ("기저 용량"으로도 불림); "2차 용량"은 초기 용량 이후 투여되는 용량이고; "3차 용량"은 2차 용량 이후 투여되는 용량이다. 초기, 2차, 및 3차 용량은 모두 같은 양의 항-인플루엔자-HA 항체를 함유할 수도 있지만, 일반적으로 투여의 빈도에 관해서는 서로 다를 수도 있다. 하지만, 특정 구체예에서, 초기, 2차 및/또는 3차 용량에 함유된 항-인플루엔자-HA 항체의 양은 치료 과정 중에 서로 다르다 (예를 들어, 적절하게 상향 또는 하향 조정됨). 특정 구체예에서, 2회 이상 (예를 들어, 2, 3, 4, 또는 5회)의 용량이 "로딩 용량"으로서 치료 양생법의 시작시 투여된 후 이어서 그 후속의 용량이 덜 빈번하게 투여된다 (예를 들어, "유지 용량").
본 발명의 특정 전형적인 구체예에서, 각각의 2차 및/또는 3차 용량은 직전 용량 이후 1 내지 48시간 (예를 들어, 1, 1½, 2, 2½, 3, 3½, 4, 4½, 5, 5½, 6, 6½, 7, 7½, 8, 8½, 9, 9½, 10, 10½, 11, 11½, 12, 12½, 13, 13½, 14, 14½, 15, 15½, 16, 16½, 17, 17½, 18, 18½, 19, 19½, 20, 20½, 21, 21½, 22, 22½, 23, 23½, 24, 24½, 25, 25½, 26, 26½, 또는 그 이상)에 투여된다. 구절 "직전 용량"은, 본원에서 사용된 바와 같이, 다회수 투여의 순서에서, 개재 용량 없이 순서상 바로 다음 용량의 투여 전에 환자에게 투여되는 항-인플루엔자-HA 항체의 용량을 의미한다.
본 발명의 이 양태에 따르는 방법은 항- 인플루엔자-HA 항체의 임의의 횟수의 2차 및/또는 3차 용량을 환자에게 투여하는 단계를 포함할 수도 있다. 예를 들어, 특정 구체예에서, 단지 1회의 2차 용량이 환자에게 투여된다. 다른 구체예에서, 2회 이상 (예를 들어, 2, 3, 4, 5, 6, 7, 8회 이상)의 2차 용량이 환자에게 투여된다. 유사하게, 특정 구체예에서, 단지 1회의 3차 용량이 환자에게 투여된다. 다른 구체예에서, 2회 이상 (예를 들어, 2, 3, 4, 5, 6, 7, 8회 이상)의 3차 용량이 환자에게 투여된다.
본 발명의 특정 구체예에서, 2차 및/또는 3차 용량이 환자에게 투여되는 빈도는 치료 양생법의 과정에 걸쳐 달라질 수 있다. 투여 빈도는 또한 임상 시험 이후 개개의 환자의 필요에 따라 의사에 의해 치료 과정 중에 조정될 수도 있다.
항체의 진단적 사용
본 발명의 항-인플루엔자-HA 항체는, 예를 들어, 진단적 목적을 위해, 샘플에서 인플루엔자-HA를 검출 및/또는 측정하는데 사용될 수도 있다. 일부 구체예는 바이러스 감염과 같은 질환 또는 장애를 검출하기 위한 검정에서 본 발명의 하나 이상의 항체의 사용을 고려한다. 인플루엔자-HA에 대한 전형적인 진단 검정은, 예를 들어, 환자로부터 얻어진 샘플을 본 발명의 항-인플루엔자-HA 항체와 접촉시키는 것을 포함하며, 항-인플루엔자-HA 항체는 검출 가능한 라벨 또는 리포터 분자로 라벨링되거나 환자 샘플로부터 인플루엔자-HA를 선택적으로 분리하기 위한 캡쳐 리간드로서 사용된다. 대안으로, 라벨링되지 않은 항-인플루엔자-HA 항체는 그 자체로 검출 가능하게 라벨링된 2차 항체와 조합하여 진단 용도로 사용될 수 있다. 검출 가능한 라벨 또는 리포터 분자는 방사성 동위원소, 예컨대 3H, 14C, 32P, 35S, 또는 125I; 형광 또는 화학 발광 모이어티, 예컨대 플루오레세인 아이소티오시아네이트, 또는 로다민; 또는 효소, 예컨대 알칼리 포스파타제, β-갈락토시다제, 홀스래디쉬 퍼옥시다제, 또는 루시퍼라제일 수 있다. 샘플에서 인플루엔자-HA를 검출 또는 측정하는데 사용될 수 있는 구체적인 전형적인 검정은 효소-결합 면역흡착 검정 (ELISA), 방사성 면역 검정 (RIA), 및 형광-활성 세포 분류법 (FACS)을 포함한다.
본 발명에 따라 인플루엔자-HA 진단 검정에 사용될 수 있는 샘플은 환자로부터 얻을 수 있는 임의의 조직 또는 유체 샘플을 포함하며, 이것은 정상 또는 생리학적 조건 하에 인플루엔자 HA, 또는 이것의 단편의 검출 가능한 양을 함유한다. 일반적으로, 건강한 환자 (예를 들어, 인플루엔자와 관련된 질환을 앓고 있지 않은 환자)로부터 얻어진 특정 샘플에서 인플루엔자 HA의 수준은 처음에 인플루엔자-HA의 베이스라인, 또는 기준 수준을 확립하기 위해 측정될 것이다. 인플루엔자-HA의 이 베이스라인 수준은 이후에 인플루엔자-HA-관련 상태, 또는 이러한 상태와 관련된 증상에 걸린 것으로 의심되는 개체로부터 얻어진 샘플에서 측정된 인플루엔자-HA의 수준과 비교될 수 있다.
인플루엔자 HA에 특이적인 항체는 추가적인 라벨 또는 모이어티를 함유하지 않을 수도 있거나, 또는 N-말단 또는 C-말단 라벨 또는 모이어티를 함유할 수도 있다. 한 구체예에서, 라벨 또는 모이어티는 비오틴이다. 결합 검정에서, 라벨의 위치는 (존재하면) 펩타이드가 결합되는 표면에 대한 펩타이드의 배향을 결정할 수도 있다. 예를 들어, 표면이 아비딘으로 코팅된 경우, N-말단 비오틴을 함유하는 펩타이드는 펩타이드의 C-말단 부분이 표면에서 멀리 위치하도록 배향될 것이다.
실시예
다음 실시예는 본 발명의 방법 및 조성물의 제조 및 사용 방법의 완전한 개시 및 설명을 당업자에게 제공하기 위해 제시되며, 발명자들이 그들의 발명으로 간주하는 것들의 범위를 제한하려는 의도는 아니다. 사용된 수치 (예를 들어, 양, 온도, 등)에 관하여 정확성을 보장하기 위해 노력하였지만, 일부 실험적 오차 및 편차가 고려되어야 한다. 달리 지시되지 않는 한, 일부는 중량부이고, 분자량은 평균 분자량이고, 온도는 섭씨 온도이고, 실온은 약 25℃이고, 압력은 대기압 또는 그 근처이다.
실시예 1: 인플루엔자 HA에 대한 인간 항체 생성
인플루엔자 HA에 대한 인간 항체를 인간 면역글로불린 중쇄 및 카파 경쇄 가변 영역을 암호화하는 DNA를 포함하는 VELOCIMMUNE® 마우스에서 생성하였다. 마우스를 인플루엔자 백신 조성물에 이어서, 다섯 개의 다른 재조합 헤마글루티닌 단백질의 혼합물을 포함하는 촉진 용량을 이용하여, 각각 1:1의 비율로, 면역화하였다. 촉진 용량에 포함된 다섯 개의 재조합 헤마글루티닌 단백질은 H1 A/New Caledonia/20/1999, H5 A/Indonesia/05/2005, H3 A/Victoria/361/2011, H7 A/Netherlands/219/2003 및 H9 A/Hong Kong/1073/1988의 헤마글루티닌이었다 (Protein Sciences, 카탈로그 번호 3006). 항체 면역 반응을 인플루엔자 A HA 특이적 면역검정에 의해 모니터링하였다. 원하는 면역 반응이 달성되었을 때, 비장세포를 수확하여 그것들의 가변성을 보존하기 위해 마우스 골수종 세포와 융합하여 하이브리도마 세포주를 형성하였다. 인플루엔자 HA-특이적 항체를 생산하는 세포주를 확인하기 위해 하이브리도마 세포주를 스크리닝하고 선택하였다. 이 기술, 및 상기 기술된 다양한 면역원을 사용하여, 여러 키메라 항체 (즉, 인간 가변 도메인 및 마우스 불변 도메인을 가지고 있는 항체)를 얻었다; 이 방식으로 생성된 전형적인 항체를 H1H11820N, H1H11829N, H1H11829N2, H2M11830N, H1H11830N2, H1H11903N 및 H1H14571N로 지칭하였다.
항-인플루엔자 HA 항체를 또한 미국 특허 7582298에서 기술된 바와 같이, 골수종 세포에 융합하지 않고 항원-양성 마우스 B 세포로부터 직접 분리하였다. 이 방법을 사용하여, 여러 완전한 인간 항-인플루엔자 HA 항체 (즉, 인간 가변 도메인 및 인간 불변 도메인을 가지고 있는 항체)를 얻었다; 이 방식으로 생성된 전형적인 항체를 H1H11723P, H1H11729P, H1H11704P, H1H11711P, H1H11714P, H1H11717P, H1H11724P, H1H11727P, H1H11730P, H1H11731P2, H1H11734P2, H1H11736P2, H1H11742P2, H1H11744P2, H1H11745P2, H1H11747P2, H1H11748P2로 지칭하였다.
이 실시예의 방법에 따라 생성된 전형적인 항체의 생물학적 성질은 하기 제시된 실시예에서 상세히 기술된다.
실시예 2: 중쇄 및 경쇄 가변 영역 아미노산 및 뉴클레오타이드 서열
표 1은 본 발명의 선택된 항-인플루엔자 HA 항체의 중쇄 및 경쇄 가변 영역 및 CDR의 아미노산 서열 식별자를 제시한다. 상응하는 핵산 서열 식별자는 표 2에서 제시된다.
아미노산 서열 식별자
서열 번호:
항체 명칭 HCVR HCDR1 HCDR2 HCDR3 LCVR LCDR1 LCDR2 LCDR3
H1H11723P 2 4 6 8 10 12 14 16
H1H11729P 18 20 22 24 26 28 30 32
H1H11820N 34 36 38 40 42 44 46 48
H1H11829N 50 52 54 56 58 60 62 64
H1H11829N2 50 52 54 56 66 68 70 72
H2aM11829N 50 52 54 56 58 60 62 64
H2M11830N 74 76 78 80 82 84 86 88
H1H11830N2 74 76 78 80 66 68 70 72
H1H11903N 90 92 94 96 98 100 102 104
H1H14571N 106 108 110 112 114 116 118 120
H2a14571N 106 108 110 112 114 116 118 120
H1H11704P 122 124 126 128 130 132 134 136
H1H11711P 138 140 142 144 146 148 150 152
H1H11714P 154 156 158 160 162 164 166 168
H1H11717P 170 172 174 176 178 180 182 184
H1H11724P 186 188 190 192 194 196 198 200
H1H11727P 202 204 206 208 210 212 214 216
H1H11730P2 218 220 222 224 226 228 230 232
H1H11731P2 234 236 238 240 66 68 70 72
H1H11734P2 242 244 246 248 66 68 70 72
H1H11736P2 250 252 254 256 66 68 70 72
H1H11742P2 258 260 262 264 66 68 70 72
H1H11744P2 266 268 270 272 66 68 70 72
H1H11745P2 274 276 278 280 66 68 70 72
H1H11747P2 282 284 286 288 66 68 70 72
H1H11748P2 290 292 294 296 66 68 70 72
핵산 서열 식별자
서열 번호:
항체 명칭 HCVR HCDR1 HCDR2 HCDR3 LCVR LCDR1 LCDR2 LCDR3
H1H11723P 1 3 5 7 9 11 13 15
H1H11729P 17 19 21 23 25 27 29 31
H1H11820N 33 35 37 39 41 43 45 47
H1H11829N 49 51 53 55 57 59 61 63
H1H11829N2 49 51 53 55 65 67 69 71
H2aM11829N 49 51 53 55 57 59 61 63
H2M11830N 73 75 77 79 81 83 85 87
H1H11830N2 73 75 77 79 65 67 69 71
H1H11903N 89 91 93 95 97 99 101 103
H1H14571N 105 107 109 111 113 115 117 119
H2a14571N 105 107 109 111 113 115 117 119
H1H11704P 121 123 125 127 129 131 133 135
H1H11711P 137 139 141 143 145 147 149 151
H1H11714P 153 155 157 159 161 163 165 167
H1H11717P 169 171 173 175 177 179 181 183
H1H11724P 185 187 189 191 193 195 197 199
H1H11727P 201 203 205 207 209 211 213 215
H1H11730P 217 219 221 223 225 227 229 231
H1H11731P2 233 235 237 239 65 67 69 71
H1H11734P2 241 243 245 247 65 67 69 71
H1H11736P2 249 251 253 255 65 67 69 71
H1H11742P2 257 259 261 263 65 67 69 71
H1H11744P2 265 267 269 271 65 67 69 71
H1H11745P2 273 275 277 279 65 67 69 71
H1H11747P2 281 283 285 287 65 67 69 71
H1H11748P2 289 291 293 295 65 67 69 71
항체는 본원에서는 전형적으로 다음 명명법에 따라 언급된다: Fc 접두사 (예를 들어 "H1H", "H2M", 등), 이어서 숫자 식별자 (예를 들어, 표 1 또는 2에서 도시된 바와 같이 "11723", "11830", 등), 이어서 "P", "P2", "N", N2, 또는 "B" 접미사. 따라서, 이 명명법에 따르면, 항체는 본원에서, 예를 들어, " H1H11723P", " H2M11830N", 등으로 언급될 수도 있다. 본원에서 사용된 항체 명칭에서 H1H 및 H2M 접두사는 항체의 특정 Fc 영역 아이소타입을 나타낸다. 예를 들어, "H1M" 항체는 마우스 IgG1 Fc를 가지고, "H2M" 항체는 마우스 IgG2 Fc (a 또는 b 아이소타입)을 가진다 (모든 가변 영역은 항체 명칭에서 처음 'H'로 표시된 바와 같이 완전한 인간이다). 당업자에 의해 이해될 수 있는 바와 같이, 특정 Fc 아이소타입을 가지는 항체는 다른 Fc 아이소타입을 가진 항체로 전환될 수 있지만 (예를 들어, 마우스 IgG1 Fc를 가진 항체는 인간 IgG4, 등을 가진 항체로 전환될 수 있음), 어떤 경우에도, 가변 도메인 (CDR 포함) - 표 1, 2, 12 또는 13에서 나타난 숫자 식별자로 표시됨 - 은 동일하게 유지될 것이며, 항원에 대한 결합 성질은 Fc 도메인의 성질과는 상관없이 동일하거나 실질적으로 유사할 것으로 예상된다.
항체 비교기
항-인플루엔자-HA 항체 대조군을 비교의 목적을 위해서 다음 실시예들 중 일부에 포함시켰다. 음성 대조군에 매칭되는 아이소타입을 또한 실시예에서 사용하였다. 본원에서 "Control I mAb"로 지칭되는 한 항-인플루엔자 HA 비교기 항체는 WO2008/028946에서 서열 번호: 65 (HC) 및 서열 번호: 91 (LC)로 제시된 바와 같은 중쇄 (HC) 및 경쇄 (LC) 아미노산 서열을 가진 항-인플루엔자 HA 항체이며 CR6261로도 불린다. WO2008/028946에서 나타난 바와 같이, 이 CR6261 항체는 각각 서열 번호: 1,2 및 3에서 나타난 중쇄 상보성 결정 영역 (HCDR) 아미노산 서열 (HCDR 1, 2 및 3) 및 각각 서열 번호: 13, 14 및 15에서 나타난 경쇄 상보성 결정 영역 (LCDR) 아미노산 서열 (LCDR1, 2 및 3)을 가진다.
실시예 3: 단클론성 항-인플루엔자 HA 항체의 Octet 결합 친화도 및 동역학 상수
선택된 정제 항-HA 단클론성 항체에 결합하는 인플루엔자 헤마글루티닌 (HA)에 대한 평형 해리 상수 (KD 값)를 실시간 생체막 간섭계 기반 바이오센서 (Octet HTX) 검정을 사용하여 결정하였다. 항-마우스 Fc (AMC) 또는 항-인간 Fc (AHC) 캡쳐로 코팅된 Octet 바이오센서를 항-HA 단클론성 항체를 캡쳐하는데 사용하였며, 각각 마우스 Fc (AbPID 접두사 H1M, H2aM, H2bM) 또는 인간 IgG1 Fc (AbPID 접두사 H1H)로 표현된다. 모든 결합 연구를 플레이트를 1000rpm의 속도로 진탕하면서 25℃에서 HBS-ET 동역학 버퍼 (10mM HEPES pH 7.4, 0.15M NaCl, 3mM EDTA, 0.05 부피% 계면활성제 Tween-20, 1mg/mL BSA)에서 수행하였다. 항체 캡쳐된 Octet 바이오센서를 HA의 다양한 균주의 다른 농도 (300nM 내지 11.11nM)를 함유하는 웰에 7분 동안 잠기게 한 후 이어서, 동역학 버퍼에서 항체 결합된 HA 단백질을 10분 동안 해리시켰다. 바이오센서를 다른 단계들 사이에 항상 동역학 버퍼로 세척하였다. Scrubber 2.0c 곡선 맞춤 프로그램을 사용하여 데이터를 가공하고 1:1 결합 모델에 맞추어서 동역학 회합 (k a ) 및 해리 (k d ) 속도 상수를 결정하였다. 결합 해리 평형 상수 (KD) 및 해리 반감기 (t½)를 동역학 속도 상수로부터 다음과 같이 계산하였다:
HA의 다양한 1군 균주에 결합하는 다른 항-HA 단클론성 항체에 대한 결합 동역학 파라미터를 표 3으로 작성하였다. 이에 더하여, 같은 항체에 대한 결합 파라미터를 2군 헤마글루티닌으로의 결합에 대하여 결정하였지만, 2군 HA로의 결합은 없었다 (데이터 미도시).
25℃에서 1군의 다른 HA 균주에 결합하는 단클론성 항체의 결합 동역학 파라미터
캡쳐된 mAb
 주사된 분석물 캡쳐된 mAb의 양 (nm) 결합된 300nM HA (nm) k a
(1/Ms)		 k d
(1/s)		 KD
(M)		 t½
(분)
H2aM11829N A/California/07/2009 (H1N1) 0.53 ±0.01 0.62 1.20E+05 1.00E-05* 8.35E-11 1155*
A/Puerto Rico/08/34 (H1N1) 0.53 ±0.01 0.59 1.09E+05 1.16E-05 1.06E-10 999
A/Vietnam/1203/2004 (H5N1) 0.52 ±0.01 0.50 3.81E+04 1.99E-05 5.23E-10 580
H1H11729P A/California/07/2009 (H1N1) 0.65 ±0.01 0.84 7.35E+04 1.00E-05* 1.36E-10 1155*
A/Puerto Rico/08/34 (H1N1) 0.67 ±0.01 0.72 8.26E+04 1.00E-05* 1.21E-10 1155*
A/Vietnam/1203/2004 (H5N1) 0.66 ±0.01 0.62 1.99E+04 3.10E-05 1.56E-09 373
H2aM14571N A/California/07/2009 (H1N1) 0.51 ±0.01 0.58 1.05E+05 1.18E-05 1.12E-10 978
A/Puerto Rico/08/34 (H1N1) 0.5
±0.02		 0.46 6.80E+04 2.44E-05 3.59E-10 474
A/Vietnam/1203/2004 (H5N1) 0.51 ±0.01 0.31 1.14E+04 1.00E-05* 8.77E-10 1155*
실시예 4-A: HA Octet 교차-경쟁
다른 항-인플루엔자 HA 단클론성 항체의 패널 간의 결합 경쟁을 Octet® HTX 바이오센서 (ForteBio, A Division of Pall Life Sciences)에서 실시간 무라벨 생체막 간섭 검정을 사용하여 결정하였다. 전체 실험을 플레이트를 1000rpm의 속도로 진탕하면서 25℃에서 0.01M HEPES pH7.4, 0.15M NaCl, 0.05 부피% 계면활성제 Tween-20, 및 1mg/mL BSA (HBS-ET Octet 버퍼)에서 수행하였다. 두 항체가 HA 상의 각각의 에피토프로의 결합에 대하여 서로 경쟁할 수 있는지를 평가하기 위해서, 사전-혼합 검정 포맷을 이용하였다. HA 단백질의 하나의 1군 균주 (California)를 사용하여 다른 항-HA 단클론성 항체 간의 교차-경쟁을 연구하였다. 이것을 달성하기 위해, 100nM의 HA 시약 (Protein Sciences)을 결합 경쟁 검정을 실행하기 전에 먼저 적어도 2시간 동안 1μM 농도의 다른 항-HA 단클론성 항체 (이후 mAb-2로 불림)와 사전-혼합하였다. 항-마우스 Fc 다클론성 항체 (Pall ForteBio Corp., # 18-5088; 이후 AMC로 불림) 또는 항-인간 Fc 다클론성 항체 (Pall ForteBio Corp., # 18-5060; 이후 AHC로 불림)으로 코팅된 Octet 바이오센서를 각각 마우스 Fc 또는 인간 Fc와 함께 발현되는 항-HA 단클론성 항체 (이후 mAb-1으로 불림)를 캡쳐하기 위해서 먼저 3분 동안 개개의 항-HA 단클론성 항체의 20μg/mL 용액을 함유하는 웰에 잠기게 하였다. 캡쳐 단계 후, Octet 바이오센서 상의 미점유(unoccupied) 항-마우스 Fc 다클론성 항체 및 항-인간 Fc 다클론성 항체를 다른 Fc와 함께 발현되는 무관한 단클론성 항체 (인간 IgG1, 마우스 IgG2a 및 마우스 IgG2b)의 혼합물의 1μM 용액을 함유하는 웰에 3분 동안 잠기게 함으로써 포화시켰다. 마지막으로, Octet 바이오센서를 100nM의 HA 및 1μM 농도의 mAb-2의 사전-혼합된 샘플을 함유하는 웰에 5분 동안 담갔다. 각 주기의 마지막에는, HA 및 mAb-2의 결합된 사전-복합체와 함께 캡쳐된 항-HA 단클론성 항체를 3번 교대로 20초 동안 20mM H3PO4에 담근 후 이어서 HBS-ET Octet 버퍼에 잠기게 함으로써 재생시켰다. 바이오센서를 실험의 모든 단계들 사이에 HBS-ET Octet 버퍼로 세척하였다. 전체 실험 과정 중에 실시간 결합 반응을 모니터링하였고 모든 단계의 마지막에는 결합 반응을 기록하였다. 분석 중에, 미점유 캡쳐 표면으로의 항-HA 단클론성 항체의 비-특이적 결합으로 인해 유발된 자가-자가 백그라운드 결합 신호 (mAb-1 = mAb-2인 경우)를 전체 컬럼에서 뺐고 교차-경쟁 표를 생성하였다 (표 4). HA 및 mAb-2의 사전-복합체에 결합하는 mAb-1의 반응을 비교하였고 다른 항-HA 단클론성 항체의 경쟁적/비-경쟁적 작용을 결정하였다.
표 4에서 나타난 바와 같이, 왼쪽의 컬럼은 AHC Octet 바이오센서를 사용하여 캡쳐된 mAb1 항체를 나타내고 오른쪽의 컬럼은 mAb1 항체와 교차-경쟁하는 항체 (mAb2)를 나타낸다.
HA의 H1N1 California 균주로의 결합에 대한 다른 항-HA 단클론성 항체의 패널들 간의 교차-경쟁
AHC Octet 바이오센서를 사용하여 캡쳐된 제1 mAb (mAb-1) mAb-1과 경쟁하는 것으로 나타난 mAb-2 항체
H2aM11829N H2aM14571N
H1H11729P
H2aM14571N H2aM11829N
H1H11729P
H1H11729P H2aM11829N
H2aM14571N
실시예 4-B: 선택된 1군-특이적 인플루엔자 A 헤마글루티닌 단클론성 항체는 시험관 내에서 다양한 1군 균주 전반에 걸쳐 인플루엔자 A의 강한 중화를 나타낸다.
세포 가변성 미세중화 검정
단클론성 항체를 폭 및 효능을 평가하기 위해서 미세중화 검정으로 테스트하였다. 간략히 말하면, 마딘-다비 개 신장 (Madin-Darby Canine Kidney; MDCK) 세포를 96-웰 플레이트에 6.0 x 103 세포/웰로 평판배양하였다. 바이러스 희석제만을 백그라운드 대조군 웰에 첨가하였다. 세포를 5% CO2 하에 37℃에서 4 내지 5시간 동안 인큐베이션하였다. 단클론성 항체를 바이러스 희석제에서 최종 농도의 4배로 희석하였다. 항체를 2배수로 1:3으로 희석하였다. 바이러스를 얼음 위에서 녹여서 적절한 사전-결정된 농도로 희석하였다. 희석된 바이러스를 희석된 mAb에 첨가하였다. mAb-바이러스 혼합물을 즉시 MDCK 세포로 옮기고 5% CO2 하에 37℃에서 72h 동안 인큐베이션하였다. 바이러스 대조군 및 미감염 세포 대조군 웰을 또한 포함시켰다. 제4 일에, 플레이트를 1200 RPM으로 3분 동안 원심분리하였다. 100 μL CelTiter-Glo 기질을 사용하여 세포를 용해시켰고 발광 (Victor X3, PerkinElmer)을 사용하여 ATP 방출을 측정하였다. 미감염 대조군과 비교하여 퍼센트 생존률을 결정하였다. IC50 값 (GraphPad Prism)을 결정하기 위해 비-선형 4PL 회귀를 사용하여 생존률 값을 분석하였다.
mAb는 다양한 H1N1, H5N1, H9N2, H13N6, 및 H16N3 균주를 포함하는 광범위한 1군 인플루엔자 A 바이러스에 대한 효능을 나타냈다 (표 5). IC50 값은 H2aM11829N에 대해서는 1.68 nM 내지 48 nM의 범위에 있고 H1H11729P에 대해서는 2.47 nM 내지 129.5 nM의 범위에 있다.
다양한 대표적인 1군 인플루엔자 균주에 대한 중화 효능. (3 내지 5회 실행의 평균이 도시됨)
PID IC50 (nM)
H1_
PR34		 H1_
WS33		 H1_
IVR148		 H1_
CA09		 H9_
RG26		 H13_
MD77		 H16_
DE09
H2aM11829N 3.29 1.68 48.0 3.50 10.2 2.11 7.39
H1H11729P 2.82 2.47 129.5 4.54 14.9 33.8 21.6
실시예 5. 선택된 1군-특이적 인플루엔자 A 헤마글루티닌 단클론성 항체는 시험관 내에서 인플루엔자 A의 강한 중화를 나타낸다.
시험관 내 미세중화 검정을 위해 전형적인 단클론성 항체 (mAb) H1H11829N2 및 H1H11729P를 선택하였다. 간략히 말하면, 마딘-다비 개 신장 (MDCK) 세포를 평판배양하고 밤새도록 인큐베이션하여 그 다음 날 80 -100% 밀집도를 달성하였다. 단클론성 항체를 바이러스 감염 배지 (VIM)에서 50 μg/mL로 희석하였고 3배수 또는 4배수로 1:2 희석하였다. H5N1 A/Vietnam/1203/2004 또는 H1N1 A/California/07/2009를 VIM에서 희석하고 희석된 항체에 첨가하여 1 h 동안 인큐베이션하였다. 샘플을 MDCK로 옮겨서 48 h 동안 인큐베이션하였다. 인큐베이션 후, 상층액 50 μL를 새로운 96-웰 플레이트로 옮겼다. 희석된 칠면조 또는 말 적혈구 세포를 상층액에 첨가하고 실온에서 30 또는 60분 동안 인큐베이션하였다. 적혈구 응집 반응(hemagglutination) 역가를 적혈구 응집 반응을 완전히 억제하는 최종 희석배수의 역수로서 기록하였다.
전형적인 항체 H1H11829N2 및 H1H11729P는 H5N1 A/Vietnam/1203/2004 및 H1N1 A/California/07/2009의 강한 중화를 나타낸다 (표 6). H5N1 A/Vietnam/1203/2004의 중화에 관하여 전형적인 항체 H1H11829N2 및 H1H11729P에 대한 평균 IC90 값은 평균 62.50 nM 및 26.05 nM이었다 (각각).
H5N1 A/Vietnam/1203/2004 및 H1N1 A/California/07/2009와 선택된 1군 헤마글루티닌-특이적 항체를 이용한 미세중화 검정 후 헤마글루티닌 역가. IC90 값 (nM)이 도시된다.
항체 번호 IC90(nM) IC90(nM)
H5N1 A/Vietnam/1203/2004 H1N1 A/California/07/2009
시험 1 시험 2 시험 1
H1H11829N2 83.3 41.7 41.7
H1H11729P 41.7 10.4 83.3
실시예 6. 인플루엔자 A 특이적 단클론성 항체를 사용하여 시험관 내 인플루엔자 감염된 세포의 보체 -의존성 세포 독성
시험관 내 보체-의존성 세포 독성 (CDC) 검정을 위해 전형적인 단클론성 항체 (mAb) H1H11829N2 및 H1H11729P를 선택하였다. 간략히 말하면, 마딘-다비 개 신장 (MDCK) 세포를 3의 MOI에서 H1N1 A/Puerto Rico/08/1934로 감염 이전에 24시간 동안 평판배양하였다. 20 내지 25시간의 인큐베이션 후, 세포를 수확하여 1 x 106개 세포/mL의 농도로 CDC 검정 배지에 재현탁하였다. 희석된 표적 세포 (20 μL)를 384-웰 플레이트의 각 웰에 첨가하였다. 단클론성 항체를 CDC 검정 배지에서 최종 시작 농도의 3배로 희석한 다음 3배수 또는 4배수로 1:2 희석하였다. CDC 검정 배지를 mAb가 없는 각 웰에 첨가하였다. 플레이트를 ~ 500 rpm으로 실온에서 ~ 2분 동안 진탕하였다. 정상 인간 혈청 보체 (NHSC)를 CDC 검정 배지에서 최종 농도 (15%)의 세 배로 제조하였고 20 μL를 각 웰에 첨가하였다. 플레이트를 실온에서 2 h 동안 인큐베이션하였고 용해제, 버퍼 및 기질을 이때에 실온으로 가져왔다. CDC 검정 배지에 디기토닌의 희석에 의해 용해제를 제조하였고 이 시약의 5 μL를 최대 용해 대조군 웰에 첨가하여 최대 신호 대조군을 확립하였다. 기질 및 버퍼를 조합하였고 20 μL를 모든 웰에 첨가하고 실온에서 10분 동안 인큐베이션하였다. 신호를 플레이트 리더 (Victor X3, Perkin Elmer)에서 검출하였다. 퍼센트 특이적 용해를 ((mAb + NHSC에 의한 용해) - (단지 NHSC만에 의한 용해))/((디기토닌 최대 용해)-(단지 NHSC만에 의한 용해)) x 100로 계산하였다. 8점 반응 곡선 (GraphPad Prism)에 대한 4-파라미터 비-선형 회귀에 의해 분석을 완료하였다. 개개의 시험 ± 표준 편차에 대한 데이터를 플롯팅하였고, 데이터는 모든 실험의 평균 ± 평균의 표준 오차로서 제공된다.
전형적인 항체 H1H11829N2 및 H1H11729P는 감염된 세포의 강한 보체-매개 용해를 나타낸다. 세 번의 무작위로 선택된 시험은 표 7에서 나타난다. 각각 전형적인 항체 H1H11829N2 및 H1H11729P에 대한 평균 EC50 값은 평균하여 41.88 nM (± 13.08 SEM)이었고 H1H11729P에 대한 평균 EC50 값은 43.25 nM (± 3.83 SEM)이었다.
1군 헤마글루티닌-특이적 항체에 의한 H1N1 A/Puerto Rico/08/1934-감염된 표적 포의 퍼센트 특이적 용해. 세 번의 반복 각각에 대한 EC50 값 (nM)이 도시된다.
AbPID EC50(nM)
시험 1 시험 2 시험 3
H1H11829N2 65.94 38.75 20.94
H1H11729P 50.83 38.49 40.44
hIgG1 무관한 mAb > 333 > 333 > 333
실시예 7: 선택된 1군-특이적 인플루엔자 A 헤마글루티닌 단클론성 항체는 생체 내에서 인플루엔자 A 감염의 강한 중화를 나타낸다.
1회 용량 예방 마우스 모델
BALB/c 마우스를 사용하는 생체 내 보호 연구를 위해 전형적인 단클론성 항체 H2aM11829N, H1H11729P 및 H2a14571N을 선택하였다. 간략히 말하면, 대략 6주령, 암컷 마우스 (대략 17.5 ± 0.5 g)를 제-1 일에 H2aM11829N, H1H11729P, H2a14571N, 또는 마우스 또는 인간 아이소타입 (음성 대조군) 항체 1 mg/kg으로 피하로 (SC) 주사하였다. 각 실험에 대하여 군 당 다섯 마리의 마우스를 포함시켰다. 주사 후 24시간 (제0 일)에, 마우스를 H1N1 A/Puerto Rico/08/1934가 들어있는 20 μL 식염수 중 10 x MLD50 (800개의 플라크 형성 단위; PFU)로 비강 내로 (IN) 공격접종하였다. 마우스의 체중을 매일 측정하였고 초기 시작 체중의 > 20 %가 손실되었을 때 희생시켰다.
전형적인 항체 H2aM11829N, H1H11729P 및 H2a14571N은 1 mg/kg에서 생체 내에서 인플루엔자 A 감염의 강한 중화를 나타낸다.
용량 반응 예방 마우스 모델
BALB/c 마우스를 사용하는 예방적 생체 내 보호 연구를 위해 전형적인 단클론성 항체 H1H11829N2 및 H1H11729P를 선택하였다. 간략히 말하면, 6주령, 암컷 마우스 (대략 17.5 ± 0.5 g)를 제-1 일에 1, 0.5, 0.1 또는 0.05 mg/kg 또는 2, 0.5, 0.2 또는 0.05 mg/kg의 H1H11829N2, H1H11729P 항체로 SC 주사하였다. 각 실험에 대하여 군 당 다섯 마리의 마우스를 포함시켰다. 담체 단백질 (무관한 hIgG1 mAb)을 1 mg/mL로 모든 용량의 mAb에 첨가하였다. 주사 후 24시간 (제0 일)에, 마우스를 H1N1 A/Puerto Rico/08/1934가 들어있는 20 μL 식염수 중 10 x MLD50 (800개의 플라크 형성 단위; PFU) 또는 H1N1 A/California/04/2009가 들어있는 20 μL 식염수 중 5 x MLD50 (5,000개의 PFU)로 비강 내로 공격접종하였다. 마우스의 체중을 매일 측정하였고 초기 시작 체중의 > 20 %가 손실되었을 때 희생시켰다.
H1_PR34로 공격접종될 때, 전형적인 항체 H1H11829N2 및 H1H11729P는 1 mg/kg에서 생체 내에서 인플루엔자 A 감염의 강한 중화를 나타낸다. 0.5 및 0.1 mg/kg에서, H1H11729P는 각각 100% 및 40% 생존률을 나타낸다 (표 8, 9 및 10). H1_CA09로 공격접종될 때, 전형적인 항체 H1H11829N2 및 H1H11729P는 2, 0.5 및 0.2 mg/kg에서 생체 내에서 인플루엔자 A 감염의 강한 중화를 나타내고 0.05 mg/kg에서는 60% 생존률을 나타냈다 (표 8, 9 및 10).
실험 1에서 H1N1 A/Puerto Rico/08/1934의 10 x MLD50으로 감염 전 1일에 예방적으로 1 mg/kg 1군 헤마글루티닌-특이적 항체의 SC 투여 후 마우스의 퍼센트 생존률
PID 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수)
식염수 (미감염) 5 100 (5/5)
H2aM11829N 5 100 (5/5)
H1H11729P 5 100 (5/5)
H2a14571N ND ND
hIgG1 아이소타입 대조군 5 0 (0/5)
mIgG2a 아이소타입 대조군 5 0 (0/5)
실험 2에서 H1N1 A/Puerto Rico/08/1934의 10 x MLD50으로 감염 전 1일에 예방적으로 1 mg/kg 1군 헤마글루티닌-특이적 항체의 SC 투여 후 마우스의 퍼센트 생존률
PID 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수)
식염수 (미감염) 5 100 (5/5)
H2aM11829N 5 100 (5/5)
H1H11729P 5 100 (5/5)
H2a14571N 5 100 (5/5)
H1N1 A/Puerto Rico/08/1934의 10 x MLD50으로 감염 전 1일에 예방적으로 1, 0.5, 0.1 또는 0.05 mg/kg 1군 헤마글루티닌-특이적 항체 또는 H1N1 A/California/04/2009의 5 x MLD50으로 감염 전 1일에 예방적으로 2, 0.5, 0.2 또는 0.05 mg/kg의 SC 투여 후 마우스의 퍼센트 생존률
공격 바이러스:
H1N1 A/Puerto Rico/08/1934		 공격 바이러스:
H1N1 A/California/04/2009
PID mAb의 용량 (mg/kg) 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수) mAb의 용량 (mg/kg) 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수)
담체 단백질이 들어있는 식염수 (미감염) N/A 5 100 (5/5) N/A 5 100 (5/5)
H1H11829N2 1 5 100 (5/5) 2 5 100 (5/5)
0.5 60 (3/5) 0.5 100 (5/5)
0.1 0 (0/5) 0.2 100 (5/5)
0.05 20 (1/5) 0.05 ND
H1H11729P 1 5 100 (5/5) 2 5 100 (5/5)
0.5 100 (5/5) 0.5 100 (5/5)
0.1 40 (2/5) 0.2 100 (5/5)
0.05 0 (0/5) 0.05 60 (3/5)
용량 반응 치료적 마우스 모델
BALB/c 마우스를 사용한 치료적 생체 내 보호 연구를 위해 전형적인 단클론성 항체 H1H11829N2 및 H1H11729P를 선택하였다. 간략히 말하면, 6주령, 암컷 마우스 (대략 17.5 ± 0.5 g)를 H1N1 A/Puerto Rico/08/1934가 들어있는 20 μL 식염수 중 10 x MLD50 (800개의 플라크 형성 단위; PFU)으로 또는 H1N1 A/California/04/2009가 들어있는 20 μL 식염수 중 5 x MLD50 (5,000개의 PFU)으로 비강 내로 감염시켰다. 감염 후 3일, 4일 또는 5일 (H1_PR34의 경우에) 또는 1일, 2일 또는 3일 (H1_CA09의 경우에) 후, 5마리 마우스의 별도의 군을 H1H11829N2, 또는 H1H11729P 항체 15 mg/kg 또는 30 mg/kg으로 IV 주사하였다. 마우스의 체중을 매일 측정하였고 초기 시작 체중의 > 20 %가 손실되었을 때 희생시켰다.
과거 및 현재의 H1N1 바이러스 균주 둘 다로 공격접종될 때, 전형적인 항체 H1H11829N2 및 H1H11729P는 생체 내에서 인플루엔자 A 감염의 강한 중화를 나타낸다 (표 11).
감염의 치료적 모델에서 마우스의 퍼센트 생존률. 마우스를 제0 일에 H1N1 A/Puerto Rico/08/1934의 10 x MLD50 또는 H1N1 A/California/04/2009의 5 x MLD50으로 감염시켰다. 제3 일, 제4 일 또는 제5 일 (H1N1 A/Puerto Rico/08/1934에 대해서) 또는 제1 일, 제2 일 또는 제3 일 (H1N1 A/California/04/2009에 대해서)에, 마우스 항체를 15 또는 30 mg/kg으로, IV 투여하였다.
공격 바이러스:
H1N1 A/Puerto Rico/08/1934 (15 mg/kg mAb)		 공격 바이러스:
H1N1 A/California/04/2009 (30 mg/kg mAb)
PID 감염 후 일 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수) 감염 후 일 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수)
H1H11829N2 3 5 40 (2/5) 1 5 100 (5/5)
4 ND 2 0 (0/5)
5 ND 3 20 (1/5)
H1H11729P 3 5 60 (3/5) 1 5 100 (5/5)
4 0 (0/5) 2 0 (0/5)
5 0 (0/5) 3 20 (1/5)
실시예 8. H5 면역원으로 면역화 후 선택된 1군-특이적 인플루엔자 A 헤마 글루티닌 단클론성 항체가 생성된다.
인플루엔자 A-HA에 대한 추가적인 인간 항체를 인간 면역글로불린 중쇄 및 카파 경쇄 가변 영역을 암호화하는 DNA를 포함하는 VELOCIMMUNE® 마우스에서 생성하였다. 나이브(naive) 마우스를 네 개의 군으로 나누었다. 1군 및 2군을 3가 인플루엔자 백신 (TIV) afluria® 2013-2014 제형 (NDC 3332-110-10)으로 면역화하였다. 3군 및 4군을 면역화되지 않은 채로 두었다. 대략 4주 후, 1군 및 3군을 50　μg　H5 DNA (H5 A/Indonesia/05/2005를 암호화하는 VRC9123)로 근육 내로 주사하였고 (Ledgerwood et al. (2011) Lancet Infect. Dis . 11: 916-924; Khurana et al. (2013) J. Infect. Dis . 208:413-417; Ledgerwood et al. (2013) J. Infect. Dis. 208: 418-422 참조) 2군 및 4군을 5　μg　H5 1가 인플루엔자 백신 (MIV; H5 A/Indonesia/05/2005를 함유하는 VRC310)으로 근육 내로 주사하였다 (Ledgerwood et al. (2011) Lancet Infect. Dis . 11: 916-924, Khurana et al. (2013) J. Infect. Dis . 208:413-417; Ledgerwood et al. (2013) J. Infect. Dis . 208: 418-422 참조). 대략 4주 후, 네 개의 군 모두를 H5 1가 인플루엔자 백신 (MIV; H5 A/Indonesia/05/2005를 암호화하는 VRC310) 5　μg으로 면역화하였다.
항-인플루엔자 A-HA 항체를 미국 특허 7582298에서 기술된 바와 같이, 골수종 세포에 융합되지 않으면서 T4 파지 피브리틴 (폴돈)-양성 마우스 B 세포의 카르복시-말단 트리머화 도메인을 함유하는, 수용체-결합 부위 (RBS) 돌연변이된, avi-태그된 H5 A/Indonesia/05/2005 및/또는 H1 A/New Caledonia/20/1999로부터 직접적으로 분리하였다. 이 방법을 사용하여, 여러 추가적인 완전한 인간 항-인플루엔자 A-HA 항체 (즉, 인간 가변 도메인 및 인간 불변 도메인을 가지고 있는 항체)를 얻었다; 이 방식으로 생성된 전형적인 항체는 하기 표 12 (아미노산 서열 식별자) 및 13 (핵산 서열 식별자)에서 발견될 수 있다. 샘플을 수용체-결합 부위 (RBS) 돌연변이된, 폴돈, avi-태그된 H5 및 H1으로의 결합에 대하여 평가하였다. 예상된 바와 같이, 거의 16개의 샘플이 15,000보다 높은 평균 형광 강도 (MFI)로 H5 단백질에 결합하였다. 하지만, 대부분의 경우에는, H1 단백질에 또한 결합하는 샘플은 H5에 대하여 높은 결합력을 가진다 (즉, 15,000 MFI 초과). 단클론성 항체의 두 개의 군을 관찰하였다; 15,000 MFI 초과로 H1에 결합된 것들 (20개의 샘플) 및 5000 MFI 초과로 H5에 결합된 것들 (44개의 샘플).
아미노산 서열 식별자
아미노산 서열 번호
항체 명칭 HCVR HCDR1 HCDR2 HCDR3 LCVR LCDR1 LCDR2 LCDR3
H1H17952B 298 300 302 304 306 308 310 312
H1H17953B 314 316 318 320 322 324 326 328
H1H17954B 330 332 334 336 338 340 342 344
H1H17955B 346 348 350 352 354 356 358 360
H1H17956B 362 364 366 368 370 372 374 376
H1H17957B 378 380 382 384 386 388 390 392
H1H17958B 394 396 398 400 402 404 406 408
H1H17959B 410 412 414 416 418 420 422 424
H1H17960B 426 428 430 432 434 436 438 440
H1H17961B 442 444 446 448 450 452 454 456
H1H17962B 458 460 462 464 466 468 470 472
H1H17963B 474 476 478 480 482 484 486 488
H1H17964B 490 492 494 496 498 500 502 504
H1H17965B 506 508 510 512 514 516 518 520
H1H17966B 522 524 526 528 530 532 534 536
H1H17967B 538 540 542 544 546 548 550 552
H1H17968B 554 556 558 560 562 564 566 568
H1H17969B 570 572 574 576 578 580 582 584
H1H17970B 586 588 590 592 594 596 598 600
H1H17971B 602 604 606 608 610 612 614 616
H1H17972B 618 620 622 624 626 628 630 632
H1H17973B 634 636 638 640 642 644 646 648
H1H17974B 650 652 654 656 658 660 662 664
H1H17975B 666 668 670 672 674 676 678 680
H1H17976B 682 684 686 688 690 692 694 696
H1H17977B 698 700 702 704 706 708 710 712
H1H17978B 714 716 718 720 722 724 726 728
H1H17979B 730 732 734 736 738 740 742 744
H1H17980B 746 748 750 752 754 756 758 760
H1H17981B 762 764 766 768 770 772 774 776
H1H17982B 778 780 782 784 786 788 790 792
H1H17983B 794 796 798 800 802 804 806 808
H1H17984B 810 812 814 816 818 820 822 824
H1H17985B 826 828 830 832 834 836 838 840
H1H17986B 842 844 846 848 850 852 854 856
H1H17987B 858 860 862 864 866 868 870 872
H1H17988B 874 876 878 880 882 884 886 888
H1H17989B 890 892 894 896 898 900 902 904
H1H17990B 906 908 910 912 914 916 918 920
H1H17991B 922 924 926 928 930 932 934 936
H1H17992B 938 940 942 944 946 948 950 952
H1H17993B 954 956 958 960 962 964 966 968
H1H17994B 970 972 974 976 978 980 982 984
H1H17995B 986 988 990 992 994 996 998 1000
H1H17996B 1002 1004 1006 1008 1010 1012 1014 1016
H1H17997B 1018 1020 1022 1024 1026 1028 1030 1032
H1H17998B 1034 1036 1038 1040 1042 1044 1046 1048
H1H17999B 1050 1052 1054 1056 1058 1060 1062 1064
H1H18000B 1066 1068 1070 1072 1074 1076 1078 1080
H1H18001B 1082 1084 1086 1088 1090 1092 1094 1096
H1H18002B 1098 1100 1102 1104 1106 1108 1110 1112
H1H18003B 1114 1116 1118 1120 1122 1124 1126 1128
H1H18004B 1130 1132 1134 1136 1138 1140 1142 1144
H1H18005B 1146 1148 1150 1152 1154 1156 1158 1160
H1H18006B 1162 1164 1166 1168 1170 1172 1174 1176
H1H18007B 1178 1180 1182 1184 1186 1188 1190 1192
H1H18008B 1194 1196 1198 1200 1202 1204 1206 1208
H1H18009B 1210 1212 1214 1216 1218 1220 1222 1224
H1H18010B 1226 1228 1230 1232 1234 1236 1238 1240
H1H18011B 1242 1244 1246 1248 1250 1252 1254 1256
H1H18012B 1258 1260 1262 1264 1266 1268 1270 1272
H1H18013B 1274 1276 1278 1280 1282 1284 1286 1288
H1H18014B 1290 1292 1294 1296 1298 1300 1302 1304
H1H18015B 1306 1308 1310 1312 1314 1316 1318 1320
H1H18016B 1322 1324 1326 1328 1330 1332 1334 1336
H1H18017B 1338 1340 1342 1344 1346 1348 1350 1352
H1H18018B 1354 1356 1358 1360 1362 1364 1366 1368
H1H18019B 1370 1372 1374 1376 1378 1380 1382 1384
H1H18020B 1386 1388 1390 1392 1394 1396 1398 1400
H1H18021B 1402 1404 1406 1408 1410 1412 1414 1416
H1H18022B 1418 1420 1422 1424 1426 1428 1430 1432
H1H18023B 1434 1436 1438 1440 1442 1444 1446 1448
H1H18024B 1450 1452 1454 1456 1458 1460 1462 1464
H1H18025B 1466 1468 1470 1472 1474 1476 1478 1480
H1H18026B 1482 1484 1486 1488 1490 1492 1494 1496
H1H18027B 1498 1500 1502 1504 1506 1508 1510 1512
H1H18028B 1514 1516 1518 1520 1522 1524 1526 1528
H1H18029B 1530 1532 1534 1536 1538 1540 1542 1544
H1H18030B 1546 1548 1550 1552 1554 1556 1558 1560
H1H18031B 1562 1564 1566 1568 1570 1572 1574 1576
H1H18032B 1578 1580 1582 1584 1586 1588 1590 1592
H1H18033B 1594 1596 1598 1600 1602 1604 1606 1608
H1H18034B 1610 1612 1614 1616 1618 1620 1622 1624
H1H18035B 1626 1628 1630 1632 1634 1636 1638 1640
H1H18037B 1642 1644 1646 1648 1650 1652 1654 1656
H1H18038B 1658 1660 1662 1664 1666 1668 1670 1672
H1H18039B 1674 1676 1678 1680 1682 1684 1686 1688
H1H18040B 1690 1692 1694 1696 1698 1700 1702 1704
H1H18041B 1706 1708 1710 1712 1714 1716 1718 1720
H1H18042B 1722 1724 1726 1728 1730 1732 1734 1736
H1H18043B 1738 1740 1742 1744 1746 1748 1750 1752
H1H18044B 1754 1756 1758 1760 1762 1764 1766 1768
H1H18045B 1770 1772 1774 1776 1778 1780 1782 1784
H1H18046B 1786 1788 1790 1792 1794 1796 1798 1800
H1H18047B 1802 1804 1806 1808 1810 1812 1814 1816
H1H18048B 1818 1820 1822 1824 1826 1828 1830 1832
H1H18049B 1834 1836 1838 1840 1842 1844 1846 1848
H1H18051B 1850 1852 1854 1856 1858 1860 1862 1864
H1H18052B 1866 1868 1870 1872 1874 1876 1878 1880
H1H18053B 1882 1884 1886 1888 1890 1892 1894 1896
H1H18054B 1898 1900 1902 1904 1906 1908 1910 1912
H1H18055B 1914 1916 1918 1920 1922 1924 1926 1928
H1H18056B 1930 1932 1934 1936 1938 1940 1942 1944
H1H18057B 1946 1948 1950 1952 1954 1956 1958 1960
H1H18058B 1962 1964 1966 1968 1970 1972 1974 1976
H1H18059B 1978 1980 1982 1984 1986 1988 1990 1992
H1H18060B 1994 1996 1998 2000 2002 2004 2006 2008
H1H18061B 2010 2012 2014 2016 2018 2020 2022 2024
H1H18062B 2026 2028 2030 2032 2034 2036 2038 2040
H1H18063B 2042 2044 2046 2048 2050 2052 2054 2056
H1H18064B 2058 2060 2062 2064 2066 2068 2070 2072
H1H18065B 2074 2076 2078 2080 2082 2084 2086 2088
H1H18066B 2090 2092 2094 2096 2098 2100 2102 2104
H1H18067B 2106 2108 2110 2112 2114 2116 2118 2120
H1H18068B 2122 2124 2126 2128 2130 2132 2134 2136
H1H18069B 2138 2140 2142 2144 2146 2148 2150 2152
H1H18070B 2154 2156 2158 2160 2162 2164 2166 2168
H1H18071B 2170 2172 2174 2176 2178 2180 2182 2184
H1H18072B 2186 2188 2190 2192 2194 2196 2198 2200
H1H18073B 2202 2204 2206 2208 2210 2212 2214 2216
H1H18074B 2218 2220 2222 2224 2226 2228 2230 2232
H1H18075B 2234 2236 2238 2240 2242 2244 2246 2248
H1H18076B 2250 2252 2254 2256 2258 2260 2262 2264
H1H18077B 2266 2268 2270 2272 2274 2276 2278 2280
H1H18078B 2282 2284 2286 2288 2290 2292 2294 2296
H1H18079B 2298 2300 2302 2304 2306 2308 2310 2312
H1H18080B 2314 2316 2318 2320 2322 2324 2326 2328
H1H18081B 2330 2332 2334 2336 2338 2340 2342 2344
H1H18082B 2346 2348 2350 2352 2354 2356 2358 2360
H1H18083B 2362 2364 2366 2368 2370 2372 2374 2376
H1H18084B 2378 2380 2382 2384 2386 2388 2390 2392
H1H18085B 2394 2396 2398 2400 2402 2404 2406 2408
H1H18086B 2410 2412 2414 2416 2418 2420 2422 2424
H1H18087B 2426 2428 2430 2432 2434 2436 2438 2440
H1H18088B 2442 2444 2446 2448 2450 2452 2454 2456
H1H18089B 2458 2460 2462 2464 2466 2468 2470 2472
H1H18090B 2474 2476 2478 2480 2482 2484 2486 2488
H1H18091B 2490 2492 2494 2496 2498 2500 2502 2504
H1H18092B 2506 2508 2510 2512 2514 2516 2518 2520
H1H18093B 2522 2524 2526 2528 2530 2532 2534 2536
H1H18094B 2538 2540 2542 2544 2546 2548 2550 2552
H1H18095B 2554 2556 2558 2560 2562 2564 2566 2568
H1H18096B 2570 2572 2574 2576 2578 2580 2582 2584
H1H18097B 2586 2588 2590 2592 2594 2596 2598 2600
H1H18098B 2602 2604 2606 2608 2610 2612 2614 2616
H1H18099B 2618 2620 2622 2624 2626 2628 2630 2632
H1H18100B 2634 2636 2638 2640 2642 2644 2646 2648
H1H18101B 2650 2652 2654 2656 2658 2660 2662 2664
H1H18102B 2666 2668 2670 2672 2674 2676 2678 2680
H1H18103B 2682 2684 2686 2688 2690 2692 2694 2696
H1H18104B 2698 2700 2702 2704 2706 2708 2710 2712
H1H18105B 2714 2716 2718 2720 2722 2724 2726 2728
H1H18107B 2730 2732 2734 2736 2738 2740 2742 2744
H1H18108B 2746 2748 2750 2752 2754 2756 2758 2760
H1H18109B 2762 2764 2766 2768 2770 2772 2774 2776
H1H18110B 2778 2780 2782 2784 2786 2788 2790 2792
H1H18111B 2794 2796 2798 2800 2802 2804 2806 2808
H1H18112B 2810 2812 2814 2816 2818 2820 2822 2824
H1H18113B 2826 2828 2830 2832 2834 2836 2838 2840
H1H18114B 2842 2844 2846 2848 2850 2852 2854 2856
H1H18115B 2858 2860 2862 2864 2866 2868 2870 2872
H1H18116B 2874 2876 2878 2880 2882 2884 2886 2888
H1H18117B 2890 2892 2894 2896 2898 2900 2902 2904
H1H18118B 2906 2908 2910 2912 2914 2916 2918 2920
H1H18119B 2922 2924 2926 2928 2930 2932 2934 2936
H1H18120B 2938 2940 2942 2944 2946 2948 2950 2952
H1H18121B 2954 2956 2958 2960 2962 2964 2966 2968
H1H18122B 2970 2972 2974 2976 2978 2980 2982 2984
H1H18123B 2986 2988 2990 2992 2994 2996 2998 3000
H1H18124B 3002 3004 3006 3008 3010 3012 3014 3016
H1H18125B 3018 3020 3022 3024 3026 3028 3030 3032
H1H18126B 3034 3036 3038 3040 3042 3044 3046 3048
H1H18127B 3050 3052 3054 3056 3058 3060 3062 3064
H1H18128B 3066 3068 3070 3072 3074 3076 3078 3080
H1H18129B 3082 3084 3086 3088 3090 3092 3094 3096
H1H18130B 3098 3100 3102 3104 3106 3108 3110 3112
H1H18131B 3114 3116 3118 3120 3122 3124 3126 3128
H1H18132B 3130 3132 3134 3136 3138 3140 3142 3144
H1H18133B 3146 3148 3150 3152 3154 3156 3158 3160
H1H18134B 3162 3164 3166 3168 3170 3172 3174 3176
H1H18135B 3178 3180 3182 3184 3186 3188 3190 3192
H1H18136B 3194 3196 3198 3200 3202 3204 3206 3208
H1H18137B 3210 3212 3214 3216 3218 3220 3222 3224
H1H18138B 3226 3228 3230 3232 3234 3236 3238 3240
H1H18139B 3242 3244 3246 3248 3250 3252 3254 3256
H1H18140B 3258 3260 3262 3264 3266 3268 3270 3272
H1H18141B 3274 3276 3278 3280 3282 3284 3286 3288
H1H18142B 3290 3292 3294 3296 3298 3300 3302 3304
H1H18143B 3306 3308 3310 3312 3314 3316 3318 3320
H1H18144B 3322 3324 3326 3328 3330 3332 3334 3336
H1H18145B 3338 3340 3342 3344 3346 3348 3350 3352
H1H18146B 3354 3356 3358 3360 3362 3364 3366 3368
H1H18147B 3370 3372 3374 3376 3378 3380 3382 3384
H1H18148B 3386 3388 3390 3392 3394 3396 3398 3400
H1H18149B 3402 3404 3406 3408 3410 3412 3414 3416
H1H18150B 3418 3420 3422 3424 3426 3428 3430 3432
H1H18151B 3434 3436 3438 3440 3442 3444 3446 3448
H1H18152B 3450 3452 3454 3456 3458 3460 3462 3464
H1H18153B 3466 3468 3470 3472 3474 3476 3478 3480
H1H18154B 3482 3484 3486 3488 3490 3492 3494 3496
H1H18155B 3498 3500 3502 3504 3506 3508 3510 3512
H1H18156B 3514 3516 3518 3520 3522 3524 3526 3528
H1H18157B 3530 3532 3534 3536 3538 3540 3542 3544
H1H18158B 3546 3548 3550 3552 3554 3556 3558 3560
H1H18159B 3562 3564 3566 3568 3570 3572 3574 3576
H1H18160B 3578 3580 3582 3584 3586 3588 3590 3592
H1H18161B 3594 3596 3598 3600 3602 3604 3606 3608
H1H18162B 3610 3612 3614 3616 3618 3620 3622 3624
H1H18163B 3626 3628 3630 3632 3634 3636 3638 3640
H1H18164B 3642 3644 3646 3648 3650 3652 3654 3656
H1H18165B 3658 3660 3662 3664 3666 3668 3670 3672
H1H18166B 3674 3676 3678 3680 3682 3684 3686 3688
H1H18167B 3690 3692 3694 3696 3698 3700 3702 3704
H1H18168B 3706 3708 3710 3712 3714 3716 3718 3720
H1H18169B 3722 3724 3726 3728 3730 3732 3734 3736
H1H18170B 3738 3740 3742 3744 3746 3748 3750 3752
H1H18171B 3754 3756 3758 3760 3762 3764 3766 3768
H1H18172B 3770 3772 3774 3776 3778 3780 3782 3784
H1H18173B 3786 3788 3790 3792 3794 3796 3798 3800
H1H18174B 3802 3804 3806 3808 3810 3812 3814 3816
H1H18175B 3818 3820 3822 3824 3826 3828 3830 3832
H1H18176B 3834 3836 3838 3840 3842 3844 3846 3848
H1H18177B 3850 3852 3854 3856 3858 3860 3862 3864
H1H18178B 3866 3868 3870 3872 3874 3876 3878 3880
H1H18179B 3882 3884 3886 3888 3890 3892 3894 3896
H1H18180B 3898 3900 3902 3904 3906 3908 3910 3912
H1H18181B 3914 3916 3918 3920 3922 3924 3926 3928
H1H18182B 3930 3932 3934 3936 3938 3940 3942 3944
H1H18183B 3946 3948 3950 3952 3954 3956 3958 3960
H1H18184B 3962 3964 3966 3968 3970 3972 3974 3976
H1H18185B 3978 3980 3982 3984 3986 3988 3990 3992
H1H18186B 3994 3996 3998 4000 4002 4004 4006 4008
H1H18187B 4010 4012 4014 4016 4018 4020 4022 4024
H1H18188B 4026 4028 4030 4032 4034 4036 4038 4040
H1H18189B 4042 4044 4046 4048 4050 4052 4054 4056
H1H18190B 4058 4060 4062 4064 4066 4068 4070 4072
H1H18191B 4074 4076 4078 4080 4082 4084 4086 4088
H1H18192B 4090 4092 4094 4096 4098 4100 4102 4104
H1H18193B 4106 4108 4110 4112 4114 4116 4118 4120
H1H18194B 4122 4124 4126 4128 4130 4132 4134 4136
H1H18195B 4138 4140 4142 4144 4146 4148 4150 4152
H1H18196B 4154 4156 4158 4160 4162 4164 4166 4168
H1H18197B 4170 4172 4174 4176 4178 4180 4182 4184
H1H18198B 4186 4188 4190 4192 4194 4196 4198 4200
H1H18199B 4202 4204 4206 4208 4210 4212 4214 4216
H1H18200B 4218 4220 4222 4224 4226 4228 4230 4232
H1H18201B 4234 4236 4238 4240 4242 4244 4246 4248
H1H18202B 4250 4252 4254 4256 4258 4260 4262 4264
H1H18203B 4266 4268 4270 4272 4274 4276 4278 4280
H1H18204B 4282 4284 4286 4288 4290 4292 4294 4296
H1H18205B 4298 4300 4302 4304 4306 4308 4310 4312
H1H18206B 4314 4316 4318 4320 4322 4324 4326 4328
H1H18207B 4330 4332 4334 4336 4338 4340 4342 4344
H1H18208B 4346 4348 4350 4352 4354 4356 4358 4360
H1H18209B 4362 4364 4366 4368 4370 4372 4374 4376
H1H18210B 4378 4380 4382 4384 4386 4388 4390 4392
H1H18211B 4394 4396 4398 4400 4402 4404 4406 4408
H1H18212B 4410 4412 4414 4416 4418 4420 4422 4424
H1H18213B 4426 4428 4430 4432 4434 4436 4438 4440
H1H18214B 4442 4444 4446 4448 4450 4452 4454 4456
H1H18216B 4458 4460 4462 4464 4466 4468 4470 4472
H1H18217B 4474 4476 4478 4480 4482 4484 4486 4488
H1H18218B 4490 4492 4494 4496 4498 4500 4502 4504
H1H18219B 4506 4508 4510 4512 4514 4516 4518 4520
H1H18220B 4522 4524 4526 4528 4530 4532 4534 4536
H1H18221B 4538 4540 4542 4544 4546 4548 4550 4552
H1H18222B 4554 4556 4558 4560 4562 4564 4566 4568
H1H18223B 4570 4572 4574 4576 4578 4580 4582 4584
H1H18224B 4586 4588 4590 4592 4594 4596 4598 4600
H1H18225B 4602 4604 4606 4608 4610 4612 4614 4616
H1H18226B 4618 4620 4622 4624 4626 4628 4630 4632
H1H18227B 4634 4636 4638 4640 4642 4644 4646 4648
H1H18228B 4650 4652 4654 4656 4658 4660 4662 4664
H1H18229B 4666 4668 4670 4672 4674 4676 4678 4680
H1H18230B 4682 4684 4686 4688 4690 4692 4694 4696
H1H18231B 4698 4700 4702 4704 4706 4708 4710 4712
H1H18232B 4714 4716 4718 4720 4722 4724 4726 4728
H1H18233B 4730 4732 4734 4736 4738 4740 4742 4744
H1H18234B 4746 4748 4750 4752 4754 4756 4758 4760
H1H18235B 4762 4764 4766 4768 4770 4772 4774 4776
H1H18236B 4778 4780 4782 4784 4786 4788 4790 4792
H1H18237B 4794 4796 4798 4800 4802 4804 4806 4808
H1H18238B 4810 4812 4814 4816 4818 4820 4822 4824
H1H18239B 4826 4828 4830 4832 4834 4836 4838 4840
H1H18240B 4842 4844 4846 4848 4850 4852 4854 4856
H1H18241B 4858 4860 4862 4864 4866 4868 4870 4872
H1H18242B 4874 4876 4878 4880 4882 4884 4886 4888
H1H18243B 4890 4892 4894 4896 4898 4900 4902 4904
H1H18244B 4906 4908 4910 4912 4914 4916 4918 4920
H1H18245B 4922 4924 4926 4928 4930 4932 4934 4936
H1H18246B 4938 4940 4942 4944 4946 4948 4950 4952
H1H18247B 4954 4956 4958 4960 4962 4964 4966 4968
H1H18248B 4970 4972 4974 4976 4978 4980 4982 4984
H1H18249B 4986 4988 4990 4992 4994 4996 4998 5000
H1H18250B 5002 5004 5006 5008 5010 5012 5014 5016
H1H18251B 5018 5020 5022 5024 5026 5028 5030 5032
H1H18252B 5034 5036 5038 5040 5042 5044 5046 5048
H1H18253B 5050 5052 5054 5056 5058 5060 5062 5064
H1H18254B 5066 5068 5070 5072 5074 5076 5078 5080
H1H18255B 5082 5084 5086 5088 5090 5092 5094 5096
H1H18256B 5098 5100 5102 5104 5106 5108 5110 5112
H1H18257B 5114 5116 5118 5120 5122 5124 5126 5128
H1H18258B 5130 5132 5134 5136 5138 5140 5142 5144
H1H18259B 5146 5148 5150 5152 5154 5156 5158 5160
H1H18261B 5162 5164 5166 5168 5170 5172 5174 5176
H1H18262B 5178 5180 5182 5184 5186 5188 5190 5192
H1H18263B 5194 5196 5198 5200 5202 5204 5206 5208
H1H18264B 5210 5212 5214 5216 5218 5220 5222 5224
H1H18265B 5226 5228 5230 5232 5234 5236 5238 5240
H1H18266B 5242 5244 5246 5248 5250 5252 5254 5256
H1H18267B 5258 5260 5262 5264 5266 5268 5270 5272
H1H18268B 5274 5276 5278 5280 5282 5284 5286 5288
H1H18269B 5290 5292 5294 5296 5298 5300 5302 5304
H1H18270B 5306 5308 5310 5312 5314 5316 5318 5320
H1H18271B 5322 5324 5326 5328 5330 5332 5334 5336
H1H18272B 5338 5340 5342 5344 5346 5348 5350 5352
H1H18274B 5354 5356 5358 5360 5362 5364 5366 5368
H1H18275B 5370 5372 5374 5376 5378 5380 5382 5384
H1H18276B 5386 5388 5390 5392 5394 5396 5398 5400
H1H18277B 5402 5404 5406 5408 5410 5412 5414 5416
H1H18278B 5418 5420 5422 5424 5426 5428 5430 5432
H1H18279B 5434 5436 5438 5440 5442 5444 5446 5448
H1H18280B 5450 5452 5454 5456 5458 5460 5462 5464
H1H18281B 5466 5468 5470 5472 5474 5476 5478 5480
H1H18282B 5482 5484 5486 5488 5490 5492 5494 5496
H1H18283B 5498 5500 5502 5504 5506 5508 5510 5512
H1H18284B 5514 5516 5518 5520 5522 5524 5526 5528
H1H18285B 5530 5532 5534 5536 5538 5540 5542 5544
H1H18286B 5546 5548 5550 5552 5554 5556 5558 5560
H1H18287B 5562 5564 5566 5568 5570 5572 5574 5576
H1H18288B 5578 5580 5582 5584 5586 5588 5590 5592
H1H18289B 5594 5596 5598 5600 5602 5604 5606 5608
H1H18290B 5610 5612 5614 5616 5618 5620 5622 5624
H1H18291B 5626 5628 5630 5632 5634 5636 5638 5640
H1H18292B 5642 5644 5646 5648 5650 5652 5654 5656
H1H18293B 5658 5660 5662 5664 5666 5668 5670 5672
H1H18294B 5674 5676 5678 5680 5682 5684 5686 5688
H1H18295B 5690 5692 5694 5696 5698 5700 5702 5704
H1H18297B 5706 5708 5710 5712 5714 5716 5718 5720
H1H18298B 5722 5724 5726 5728 5730 5732 5734 5736
H1H18299B 5738 5740 5742 5744 5746 5748 5750 5752
H1H18300B 5754 5756 5758 5760 5762 5764 5766 5768
H1H18301B 5770 5772 5774 5776 5778 5780 5782 5784
H1H18302B 5786 5788 5790 5792 5794 5796 5798 5800
H1H18303B 5802 5804 5806 5808 5810 5812 5814 5816
H1H18304B 5818 5820 5822 5824 5826 5828 5830 5832
H1H18305B 5834 5836 5838 5840 5842 5844 5846 5848
H1H18306B 5850 5852 5854 5856 5858 5860 5862 5864
H1H18307B 5866 5868 5870 5872 5874 5876 5878 5880
H1H18308B 5882 5884 5886 5888 5890 5892 5894 5896
H1H18309B 5898 5900 5902 5904 5906 5908 5910 5912
H1H18310B 5914 5916 5918 5920 5922 5924 5926 5928
H1H18311B 5930 5932 5934 5936 5938 5940 5942 5944
H1H18312B 5946 5948 5950 5952 5954 5956 5958 5960
H1H18313B 5962 5964 5966 5968 5970 5972 5974 5976
H1H18314B 5978 5980 5982 5984 5986 5988 5990 5992
H1H18315B 5994 5996 5998 6000 6002 6004 6006 6008
H1H18316B 6010 6012 6014 6016 6018 6020 6022 6024
H1H18317B 6026 6028 6030 6032 6034 6036 6038 6040
H1H18318B 6042 6044 6046 6048 6050 6052 6054 6056
H1H18319B 6058 6060 6062 6064 6066 6068 6070 6072
H1H18320B 6074 6076 6078 6080 6082 6084 6086 6088
H1H18321B 6090 6092 6094 6096 6098 6100 6102 6104
H1H18322B 6106 6108 6110 6112 6114 6116 6118 6120
H1H18323B 6122 6124 6126 6128 6130 6132 6134 6136
H1H18324B 6138 6140 6142 6144 6146 6148 6150 6152
H1H18325B 6154 6156 6158 6160 6162 6164 6166 6168
H1H18326B 6170 6172 6174 6176 6178 6180 6182 6184
H1H18327B 6186 6188 6190 6192 6194 6196 6198 6200
H1H18328B 6202 6204 6206 6208 6210 6212 6214 6216
H1H18329B 6218 6220 6222 6224 6226 6228 6230 6232
H1H18330B 6234 6236 6238 6240 6242 6244 6246 6248
H1H18331B 6250 6252 6254 6256 6258 6260 6262 6264
H1H18332B 6266 6268 6270 6272 6274 6276 6278 6280
H1H18333B 6282 6284 6286 6288 6290 6292 6294 6296
H1H18334B 6298 6300 6302 6304 6306 6308 6310 6312
H1H18335B 6314 6316 6318 6320 6322 6324 6326 6328
핵산 서열 식별자
핵산 서열 번호
항체 명칭 HCVR HCDR1 HCDR2 HCDR3 LCVR LCDR1 LCDR2 LCDR3
H1H17952B 297 299 301 303 305 307 309 311
H1H17953B 313 315 317 319 321 323 325 327
H1H17954B 329 331 333 335 337 339 341 343
H1H17955B 345 347 349 351 353 355 357 359
H1H17956B 361 363 365 367 369 371 373 375
H1H17957B 377 379 381 383 385 387 389 391
H1H17958B 393 395 397 399 401 403 405 407
H1H17959B 409 411 413 415 417 419 421 423
H1H17960B 425 427 429 431 433 435 437 439
H1H17961B 441 443 445 447 449 451 453 455
H1H17962B 457 459 461 463 465 467 469 471
H1H17963B 473 475 477 479 481 483 485 487
H1H17964B 489 491 493 495 497 499 501 503
H1H17965B 505 507 509 511 513 515 517 519
H1H17966B 521 523 525 527 529 531 533 535
H1H17967B 537 539 541 543 545 547 549 551
H1H17968B 553 555 557 559 561 563 565 567
H1H17969B 569 571 573 575 577 579 581 583
H1H17970B 585 587 589 591 593 595 597 599
H1H17971B 601 603 605 607 609 611 613 615
H1H17972B 617 619 621 623 625 627 629 631
H1H17973B 633 635 637 639 641 643 645 647
H1H17974B 649 651 653 655 657 659 661 663
H1H17975B 665 667 669 671 673 675 677 679
H1H17976B 681 683 685 687 689 691 693 695
H1H17977B 697 699 701 703 705 707 709 711
H1H17978B 713 715 717 719 721 723 725 727
H1H17979B 729 731 733 735 737 739 741 743
H1H17980B 745 747 749 751 753 755 757 759
H1H17981B 761 763 765 767 769 771 773 775
H1H17982B 777 779 781 783 785 787 789 791
H1H17983B 793 795 797 799 801 803 805 807
H1H17984B 809 811 813 815 817 819 821 823
H1H17985B 825 827 829 831 833 835 837 839
H1H17986B 841 843 845 847 849 851 853 855
H1H17987B 857 859 861 863 865 867 869 871
H1H17988B 873 875 877 879 881 883 885 887
H1H17989B 889 891 893 895 897 899 901 903
H1H17990B 905 907 909 911 913 915 917 919
H1H17991B 921 923 925 927 929 931 933 935
H1H17992B 937 939 941 943 945 947 949 951
H1H17993B 953 955 957 959 961 963 965 967
H1H17994B 969 971 973 975 977 979 981 983
H1H17995B 985 987 989 991 993 995 997 999
H1H17996B 1001 1003 1005 1007 1009 1011 1013 1015
H1H17997B 1017 1019 1021 1023 1025 1027 1029 1031
H1H17998B 1033 1035 1037 1039 1041 1043 1045 1047
H1H17999B 1049 1051 1053 1055 1057 1059 1061 1063
H1H18000B 1065 1067 1069 1071 1073 1075 1077 1079
H1H18001B 1081 1083 1085 1087 1089 1091 1093 1095
H1H18002B 1097 1099 1101 1103 1105 1107 1109 1111
H1H18003B 1113 1115 1117 1119 1121 1123 1125 1127
H1H18004B 1129 1131 1133 1135 1137 1139 1141 1143
H1H18005B 1145 1147 1149 1151 1153 1155 1157 1159
H1H18006B 1161 1163 1165 1167 1169 1171 1173 1175
H1H18007B 1177 1179 1181 1183 1185 1187 1189 1191
H1H18008B 1193 1195 1197 1199 1201 1203 1205 1207
H1H18009B 1209 1211 1213 1215 1217 1219 1221 1223
H1H18010B 1225 1227 1229 1231 1233 1235 1237 1239
H1H18011B 1241 1243 1245 1247 1249 1251 1253 1255
H1H18012B 1257 1259 1261 1263 1265 1267 1269 1271
H1H18013B 1273 1275 1277 1279 1281 1283 1285 1287
H1H18014B 1289 1291 1293 1295 1297 1299 1301 1303
H1H18015B 1305 1307 1309 1311 1313 1315 1317 1319
H1H18016B 1321 1323 1325 1327 1329 1331 1333 1335
H1H18017B 1337 1339 1341 1343 1345 1347 1349 1351
H1H18018B 1353 1355 1357 1359 1361 1363 1365 1367
H1H18019B 1369 1371 1373 1375 1377 1379 1381 1383
H1H18020B 1385 1387 1389 1391 1393 1395 1397 1399
H1H18021B 1401 1403 1405 1407 1409 1411 1413 1415
H1H18022B 1417 1419 1421 1423 1425 1427 1429 1431
H1H18023B 1433 1435 1437 1439 1441 1443 1445 1447
H1H18024B 1449 1451 1453 1455 1457 1459 1461 1463
H1H18025B 1465 1467 1469 1471 1473 1475 1477 1479
H1H18026B 1481 1483 1485 1487 1489 1491 1493 1495
H1H18027B 1497 1499 1501 1503 1505 1507 1509 1511
H1H18028B 1513 1515 1517 1519 1521 1523 1525 1527
H1H18029B 1529 1531 1533 1535 1537 1539 1541 1543
H1H18030B 1545 1547 1549 1551 1553 1555 1557 1559
H1H18031B 1561 1563 1565 1567 1569 1571 1573 1575
H1H18032B 1577 1579 1581 1583 1585 1587 1589 1591
H1H18033B 1593 1595 1597 1599 1601 1603 1605 1607
H1H18034B 1609 1611 1613 1615 1617 1619 1621 1623
H1H18035B 1625 1627 1629 1631 1633 1635 1637 1639
H1H18037B 1641 1643 1645 1647 1649 1651 1653 1655
H1H18038B 1657 1659 1661 1663 1665 1667 1669 1671
H1H18039B 1673 1675 1677 1679 1681 1683 1685 1687
H1H18040B 1689 1691 1693 1695 1697 1699 1701 1703
H1H18041B 1705 1707 1709 1711 1713 1715 1717 1719
H1H18042B 1721 1723 1725 1727 1729 1731 1733 1735
H1H18043B 1737 1739 1741 1743 1745 1747 1749 1751
H1H18044B 1753 1755 1757 1759 1761 1763 1765 1767
H1H18045B 1769 1771 1773 1775 1777 1779 1781 1783
H1H18046B 1785 1787 1789 1791 1793 1795 1797 1799
H1H18047B 1801 1803 1805 1807 1809 1811 1813 1815
H1H18048B 1817 1819 1821 1823 1825 1827 1829 1831
H1H18049B 1833 1835 1837 1839 1841 1843 1845 1847
H1H18051B 1849 1851 1853 1855 1857 1859 1861 1863
H1H18052B 1865 1867 1869 1871 1873 1875 1877 1879
H1H18053B 1881 1883 1885 1887 1889 1891 1893 1895
H1H18054B 1897 1899 1901 1903 1905 1907 1909 1911
H1H18055B 1913 1915 1917 1919 1921 1923 1925 1927
H1H18056B 1929 1931 1933 1935 1937 1939 1941 1943
H1H18057B 1945 1947 1949 1951 1953 1955 1957 1959
H1H18058B 1961 1963 1965 1967 1969 1971 1973 1975
H1H18059B 1977 1979 1981 1983 1985 1987 1989 1991
H1H18060B 1993 1995 1997 1999 2001 2003 2005 2007
H1H18061B 2009 2011 2013 2015 2017 2019 2021 2023
H1H18062B 2025 2027 2029 2031 2033 2035 2037 2039
H1H18063B 2041 2043 2045 2047 2049 2051 2053 2055
H1H18064B 2057 2059 2061 2063 2065 2067 2069 2071
H1H18065B 2073 2075 2077 2079 2081 2083 2085 2087
H1H18066B 2089 2091 2093 2095 2097 2099 2101 2103
H1H18067B 2105 2107 2109 2111 2113 2115 2117 2119
H1H18068B 2121 2123 2125 2127 2129 2131 2133 2135
H1H18069B 2137 2139 2141 2143 2145 2147 2149 2151
H1H18070B 2153 2155 2157 2159 2161 2163 2165 2167
H1H18071B 2169 2171 2173 2175 2177 2179 2181 2183
H1H18072B 2185 2187 2189 2191 2193 2195 2197 2199
H1H18073B 2201 2203 2205 2207 2209 2211 2213 2215
H1H18074B 2217 2219 2221 2223 2225 2227 2229 2231
H1H18075B 2233 2235 2237 2239 2241 2243 2245 2247
H1H18076B 2249 2251 2253 2255 2257 2259 2261 2263
H1H18077B 2265 2267 2269 2271 2273 2275 2277 2279
H1H18078B 2281 2283 2285 2287 2289 2291 2293 2295
H1H18079B 2297 2299 2301 2303 2305 2307 2309 2311
H1H18080B 2313 2315 2317 2319 2321 2323 2325 2327
H1H18081B 2329 2331 2333 2335 2337 2339 2341 2343
H1H18082B 2345 2347 2349 2351 2353 2355 2357 2359
H1H18083B 2361 2363 2365 2367 2369 2371 2373 2375
H1H18084B 2377 2379 2381 2383 2385 2387 2389 2391
H1H18085B 2393 2395 2397 2399 2401 2403 2405 2407
H1H18086B 2409 2411 2413 2415 2417 2419 2421 2423
H1H18087B 2425 2427 2429 2431 2433 2435 2437 2439
H1H18088B 2441 2443 2445 2447 2449 2451 2453 2455
H1H18089B 2457 2459 2461 2463 2465 2467 2469 2471
H1H18090B 2473 2475 2477 2479 2481 2483 2485 2487
H1H18091B 2489 2491 2493 2495 2497 2499 2501 2503
H1H18092B 2505 2507 2509 2511 2513 2515 2517 2519
H1H18093B 2521 2523 2525 2527 2529 2531 2533 2535
H1H18094B 2537 2539 2541 2543 2545 2547 2549 2551
H1H18095B 2553 2555 2557 2559 2561 2563 2565 2567
H1H18096B 2569 2571 2573 2575 2577 2579 2581 2583
H1H18097B 2585 2587 2589 2591 2593 2595 2597 2599
H1H18098B 2601 2603 2605 2607 2609 2611 2613 2615
H1H18099B 2617 2619 2621 2623 2625 2627 2629 2631
H1H18100B 2633 2635 2637 2639 2641 2643 2645 2647
H1H18101B 2649 2651 2653 2655 2657 2659 2661 2663
H1H18102B 2665 2667 2669 2671 2673 2675 2677 2679
H1H18103B 2681 2683 2685 2687 2689 2691 2693 2695
H1H18104B 2697 2699 2701 2703 2705 2707 2709 2711
H1H18105B 2713 2715 2717 2719 2721 2723 2725 2727
H1H18107B 2729 2731 2733 2735 2737 2739 2741 2743
H1H18108B 2745 2747 2749 2751 2753 2755 2757 2759
H1H18109B 2761 2763 2765 2767 2769 2771 2773 2775
H1H18110B 2777 2779 2781 2783 2785 2787 2789 2791
H1H18111B 2793 2795 2797 2799 2801 2803 2805 2807
H1H18112B 2809 2811 2813 2815 2817 2819 2821 2823
H1H18113B 2825 2827 2829 2831 2833 2835 2837 2839
H1H18114B 2841 2843 2845 2847 2849 2851 2853 2855
H1H18115B 2857 2859 2861 2863 2865 2867 2869 2871
H1H18116B 2873 2875 2877 2879 2881 2883 2885 2887
H1H18117B 2889 2891 2893 2895 2897 2899 2901 2903
H1H18118B 2905 2907 2909 2911 2913 2915 2917 2919
H1H18119B 2921 2923 2925 2927 2929 2931 2933 2935
H1H18120B 2937 2939 2941 2943 2945 2947 2949 2951
H1H18121B 2953 2955 2957 2959 2961 2963 2965 2967
H1H18122B 2969 2971 2973 2975 2977 2979 2981 2983
H1H18123B 2985 2987 2989 2991 2993 2995 2997 2999
H1H18124B 3001 3003 3005 3007 3009 3011 3013 3015
H1H18125B 3017 3019 3021 3023 3025 3027 3029 3031
H1H18126B 3033 3035 3037 3039 3041 3043 3045 3047
H1H18127B 3049 3051 3053 3055 3057 3059 3061 3063
H1H18128B 3065 3067 3069 3071 3073 3075 3077 3079
H1H18129B 3081 3083 3085 3087 3089 3091 3093 3095
H1H18130B 3097 3099 3101 3103 3105 3107 3109 3111
H1H18131B 3113 3115 3117 3119 3121 3123 3125 3127
H1H18132B 3129 3131 3133 3135 3137 3139 3141 3143
H1H18133B 3145 3147 3149 3151 3153 3155 3157 3159
H1H18134B 3161 3163 3165 3167 3169 3171 3173 3175
H1H18135B 3177 3179 3181 3183 3185 3187 3189 3191
H1H18136B 3193 3195 3197 3199 3201 3203 3205 3207
H1H18137B 3209 3211 3213 3215 3217 3219 3221 3223
H1H18138B 3225 3227 3229 3231 3233 3235 3237 3239
H1H18139B 3241 3243 3245 3247 3249 3251 3253 3255
H1H18140B 3257 3259 3261 3263 3265 3267 3269 3271
H1H18141B 3273 3275 3277 3279 3281 3283 3285 3287
H1H18142B 3289 3291 3293 3295 3297 3299 3301 3303
H1H18143B 3305 3307 3309 3311 3313 3315 3317 3319
H1H18144B 3321 3323 3325 3327 3329 3331 3333 3335
H1H18145B 3337 3339 3341 3343 3345 3347 3349 3351
H1H18146B 3353 3355 3357 3359 3361 3363 3365 3367
H1H18147B 3369 3371 3373 3375 3377 3379 3381 3383
H1H18148B 3385 3387 3389 3391 3393 3395 3397 3399
H1H18149B 3401 3403 3405 3407 3409 3411 3413 3415
H1H18150B 3417 3419 3421 3423 3425 3427 3429 3431
H1H18151B 3433 3435 3437 3439 3441 3443 3445 3447
H1H18152B 3449 3451 3453 3455 3457 3459 3461 3463
H1H18153B 3465 3467 3469 3471 3473 3475 3477 3479
H1H18154B 3481 3483 3485 3487 3489 3491 3493 3495
H1H18155B 3497 3499 3501 3503 3505 3507 3509 3511
H1H18156B 3513 3515 3517 3519 3521 3523 3525 3527
H1H18157B 3529 3531 3533 3535 3537 3539 3541 3543
H1H18158B 3545 3547 3549 3551 3553 3555 3557 3559
H1H18159B 3561 3563 3565 3567 3569 3571 3573 3575
H1H18160B 3577 3579 3581 3583 3585 3587 3589 3591
H1H18161B 3593 3595 3597 3599 3601 3603 3605 3607
H1H18162B 3609 3611 3613 3615 3617 3619 3621 3623
H1H18163B 3625 3627 3629 3631 3633 3635 3637 3639
H1H18164B 3641 3643 3645 3647 3649 3651 3653 3655
H1H18165B 3657 3659 3661 3663 3665 3667 3669 3671
H1H18166B 3673 3675 3677 3679 3681 3683 3685 3687
H1H18167B 3689 3691 3693 3695 3697 3699 3701 3703
H1H18168B 3705 3707 3709 3711 3713 3715 3717 3719
H1H18169B 3721 3723 3725 3727 3729 3731 3733 3735
H1H18170B 3737 3739 3741 3743 3745 3747 3749 3751
H1H18171B 3753 3755 3757 3759 3761 3763 3765 3767
H1H18172B 3769 3771 3773 3775 3777 3779 3781 3783
H1H18173B 3785 3787 3789 3791 3793 3795 3797 3799
H1H18174B 3801 3803 3805 3807 3809 3811 3813 3815
H1H18175B 3817 3819 3821 3823 3825 3827 3829 3831
H1H18176B 3833 3835 3837 3839 3841 3843 3845 3847
H1H18177B 3849 3851 3853 3855 3857 3859 3861 3863
H1H18178B 3865 3867 3869 3871 3873 3875 3877 3879
H1H18179B 3881 3883 3885 3887 3889 3891 3893 3895
H1H18180B 3897 3899 3901 3903 3905 3907 3909 3911
H1H18181B 3913 3915 3917 3919 3921 3923 3925 3927
H1H18182B 3929 3931 3933 3935 3937 3939 3941 3943
H1H18183B 3945 3947 3949 3951 3953 3955 3957 3959
H1H18184B 3961 3963 3965 3967 3969 3971 3973 3975
H1H18185B 3977 3979 3981 3983 3985 3987 3989 3991
H1H18186B 3993 3995 3997 3999 4001 4003 4005 4007
H1H18187B 4009 4011 4013 4015 4017 4019 4021 4023
H1H18188B 4025 4027 4029 4031 4033 4035 4037 4039
H1H18189B 4041 4043 4045 4047 4049 4051 4053 4055
H1H18190B 4057 4059 4061 4063 4065 4067 4069 4071
H1H18191B 4073 4075 4077 4079 4081 4083 4085 4087
H1H18192B 4089 4091 4093 4095 4097 4099 4101 4103
H1H18193B 4105 4107 4109 4111 4113 4115 4117 4119
H1H18194B 4121 4123 4125 4127 4129 4131 4133 4135
H1H18195B 4137 4139 4141 4143 4145 4147 4149 4151
H1H18196B 4153 4155 4157 4159 4161 4163 4165 4167
H1H18197B 4169 4171 4173 4175 4177 4179 4181 4183
H1H18198B 4185 4187 4189 4191 4193 4195 4197 4199
H1H18199B 4201 4203 4205 4207 4209 4211 4213 4215
H1H18200B 4217 4219 4221 4223 4225 4227 4229 4231
H1H18201B 4233 4235 4237 4239 4241 4243 4245 4247
H1H18202B 4249 4251 4253 4255 4257 4259 4261 4263
H1H18203B 4265 4267 4269 4271 4273 4275 4277 4279
H1H18204B 4281 4283 4285 4287 4289 4291 4293 4295
H1H18205B 4297 4299 4301 4303 4305 4307 4309 4311
H1H18206B 4313 4315 4317 4319 4321 4323 4325 4327
H1H18207B 4329 4331 4333 4335 4337 4339 4341 4343
H1H18208B 4345 4347 4349 4351 4353 4355 4357 4359
H1H18209B 4361 4363 4365 4367 4369 4371 4373 4375
H1H18210B 4377 4379 4381 4383 4385 4387 4389 4391
H1H18211B 4393 4395 4397 4399 4401 4403 4405 4407
H1H18212B 4409 4411 4413 4415 4417 4419 4421 4423
H1H18213B 4425 4427 4429 4431 4433 4435 4437 4439
H1H18214B 4441 4443 4445 4447 4449 4451 4453 4455
H1H18216B 4457 4459 4461 4463 4465 4467 4469 4471
H1H18217B 4473 4475 4477 4479 4481 4483 4485 4487
H1H18218B 4489 4491 4493 4495 4497 4499 4501 4503
H1H18219B 4505 4507 4509 4511 4513 4515 4517 4519
H1H18220B 4521 4523 4525 4527 4529 4531 4533 4535
H1H18221B 4537 4539 4541 4543 4545 4547 4549 4551
H1H18222B 4553 4555 4557 4559 4561 4563 4565 4567
H1H18223B 4569 4571 4573 4575 4577 4579 4581 4583
H1H18224B 4585 4587 4589 4591 4593 4595 4597 4599
H1H18225B 4601 4603 4605 4607 4609 4611 4613 4615
H1H18226B 4617 4619 4621 4623 4625 4627 4629 4631
H1H18227B 4633 4635 4637 4639 4641 4643 4645 4647
H1H18228B 4649 4651 4653 4655 4657 4659 4661 4663
H1H18229B 4665 4667 4669 4671 4673 4675 4677 4679
H1H18230B 4681 4683 4685 4687 4689 4691 4693 4695
H1H18231B 4697 4699 4701 4703 4705 4707 4709 4711
H1H18232B 4713 4715 4717 4719 4721 4723 4725 4727
H1H18233B 4729 4731 4733 4735 4737 4739 4741 4743
H1H18234B 4745 4747 4749 4751 4753 4755 4757 4759
H1H18235B 4761 4763 4765 4767 4769 4771 4773 4775
H1H18236B 4777 4779 4781 4783 4785 4787 4789 4791
H1H18237B 4793 4795 4797 4799 4801 4803 4805 4807
H1H18238B 4809 4811 4813 4815 4817 4819 4821 4823
H1H18239B 4825 4827 4829 4831 4833 4835 4837 4839
H1H18240B 4841 4843 4845 4847 4849 4851 4853 4855
H1H18241B 4857 4859 4861 4863 4865 4867 4869 4871
H1H18242B 4873 4875 4877 4879 4881 4883 4885 4887
H1H18243B 4889 4891 4893 4895 4897 4899 4901 4903
H1H18244B 4905 4907 4909 4911 4913 4915 4917 4919
H1H18245B 4921 4923 4925 4927 4929 4931 4933 4935
H1H18246B 4937 4939 4941 4943 4945 4947 4949 4951
H1H18247B 4953 4955 4957 4959 4961 4963 4965 4967
H1H18248B 4969 4971 4973 4975 4977 4979 4981 4983
H1H18249B 4985 4987 4989 4991 4993 4995 4997 4999
H1H18250B 5001 5003 5005 5007 5009 5011 5013 5015
H1H18251B 5017 5019 5021 5023 5025 5027 5029 5031
H1H18252B 5033 5035 5037 5039 5041 5043 5045 5047
H1H18253B 5049 5051 5053 5055 5057 5059 5061 5063
H1H18254B 5065 5067 5069 5071 5073 5075 5077 5079
H1H18255B 5081 5083 5085 5087 5089 5091 5093 5095
H1H18256B 5097 5099 5101 5103 5105 5107 5109 5111
H1H18257B 5113 5115 5117 5119 5121 5123 5125 5127
H1H18258B 5129 5131 5133 5135 5137 5139 5141 5143
H1H18259B 5145 5147 5149 5151 5153 5155 5157 5159
H1H18261B 5161 5163 5165 5167 5169 5171 5173 5175
H1H18262B 5177 5179 5181 5183 5185 5187 5189 5191
H1H18263B 5193 5195 5197 5199 5201 5203 5205 5207
H1H18264B 5209 5211 5213 5215 5217 5219 5221 5223
H1H18265B 5225 5227 5229 5231 5233 5235 5237 5239
H1H18266B 5241 5243 5245 5247 5249 5251 5253 5255
H1H18267B 5257 5259 5261 5263 5265 5267 5269 5271
H1H18268B 5273 5275 5277 5279 5281 5283 5285 5287
H1H18269B 5289 5291 5293 5295 5297 5299 5301 5303
H1H18270B 5305 5307 5309 5311 5313 5315 5317 5319
H1H18271B 5321 5323 5325 5327 5329 5331 5333 5335
H1H18272B 5337 5339 5341 5343 5345 5347 5349 5351
H1H18274B 5353 5355 5357 5359 5361 5363 5365 5367
H1H18275B 5369 5371 5373 5375 5377 5379 5381 5383
H1H18276B 5385 5387 5389 5391 5393 5395 5397 5399
H1H18277B 5401 5403 5405 5407 5409 5411 5413 5415
H1H18278B 5417 5419 5421 5423 5425 5427 5429 5431
H1H18279B 5433 5435 5437 5439 5441 5443 5445 5447
H1H18280B 5449 5451 5453 5455 5457 5459 5461 5463
H1H18281B 5465 5467 5469 5471 5473 5475 5477 5479
H1H18282B 5481 5483 5485 5487 5489 5491 5493 5495
H1H18283B 5497 5499 5501 5503 5505 5507 5509 5511
H1H18284B 5513 5515 5517 5519 5521 5523 5525 5527
H1H18285B 5529 5531 5533 5535 5537 5539 5541 5543
H1H18286B 5545 5547 5549 5551 5553 5555 5557 5559
H1H18287B 5561 5563 5565 5567 5569 5571 5573 5575
H1H18288B 5577 5579 5581 5583 5585 5587 5589 5591
H1H18289B 5593 5595 5597 5599 5601 5603 5605 5607
H1H18290B 5609 5611 5613 5615 5617 5619 5621 5623
H1H18291B 5625 5627 5629 5631 5633 5635 5637 5639
H1H18292B 5641 5643 5645 5647 5649 5651 5653 5655
H1H18293B 5657 5659 5661 5663 5665 5667 5669 5671
H1H18294B 5673 5675 5677 5679 5681 5683 5685 5687
H1H18295B 5689 5691 5693 5695 5697 5699 5701 5703
H1H18297B 5705 5707 5709 5711 5713 5715 5717 5719
H1H18298B 5721 5723 5725 5727 5729 5731 5733 5735
H1H18299B 5737 5739 5741 5743 5745 5747 5749 5751
H1H18300B 5753 5755 5757 5759 5761 5763 5765 5767
H1H18301B 5769 5771 5773 5775 5777 5779 5781 5783
H1H18302B 5785 5787 5789 5791 5793 5795 5797 5799
H1H18303B 5801 5803 5805 5807 5809 5811 5813 5815
H1H18304B 5817 5819 5821 5823 5825 5827 5829 5831
H1H18305B 5833 5835 5837 5839 5841 5843 5845 5847
H1H18306B 5849 5851 5853 5855 5857 5859 5861 5863
H1H18307B 5865 5867 5869 5871 5873 5875 5877 5879
H1H18308B 5881 5883 5885 5887 5889 5891 5893 5895
H1H18309B 5897 5899 5901 5903 5905 5907 5909 5911
H1H18310B 5913 5915 5917 5919 5921 5923 5925 5927
H1H18311B 5929 5931 5933 5935 5937 5939 5941 5943
H1H18312B 5945 5947 5949 5951 5953 5955 5957 5959
H1H18313B 5961 5963 5965 5967 5969 5971 5973 5975
H1H18314B 5977 5979 5981 5983 5985 5987 5989 5991
H1H18315B 5993 5995 5997 5999 6001 6003 6005 6007
H1H18316B 6009 6011 6013 6015 6017 6019 6021 6023
H1H18317B 6025 6027 6029 6031 6033 6035 6037 6039
H1H18318B 6041 6043 6045 6047 6049 6051 6053 6055
H1H18319B 6057 6059 6061 6063 6065 6067 6069 6071
H1H18320B 6073 6075 6077 6079 6081 6083 6085 6087
H1H18321B 6089 6091 6093 6095 6097 6099 6101 6103
H1H18322B 6105 6107 6109 6111 6113 6115 6117 6119
H1H18323B 6121 6123 6125 6127 6129 6131 6133 6135
H1H18324B 6137 6139 6141 6143 6145 6147 6149 6151
H1H18325B 6153 6155 6157 6159 6161 6163 6165 6167
H1H18326B 6169 6171 6173 6175 6177 6179 6181 6183
H1H18327B 6185 6187 6189 6191 6193 6195 6197 6199
H1H18328B 6201 6203 6205 6207 6209 6211 6213 6215
H1H18329B 6217 6219 6221 6223 6225 6227 6229 6231
H1H18330B 6233 6235 6237 6239 6241 6243 6245 6247
H1H18331B 6249 6251 6253 6255 6257 6259 6261 6263
H1H18332B 6265 6267 6269 6271 6273 6275 6277 6279
H1H18333B 6281 6283 6285 6287 6289 6291 6293 6295
H1H18334B 6297 6299 6301 6303 6305 6307 6309 6311
H1H18335B 6313 6315 6317 6319 6321 6323 6325 6327
실시예 9. H1H11729P는 비교기 항체 (Control I mAb )와 비교하여 마우스 및 비-인간 영장류 (NHP)에서 우수한 약동학적 프로파일을 가진다.
마우스 및 비-인간 영장류에서 H1H11729P의 약동학적 프로파일을 비교기 항체와 비교하기 위한 연구를 시행하였다. 본원에서 Control I mAb로 지칭되는 한 항-인플루엔자 HA 비교기 항체는 WO2008/028946에서 서열 번호: 65 (HC) 및 서열 번호: 91 (LC)로서 제시된 중쇄 (HC) 및 경쇄 (LC) 아미노산 서열을 가지는 항-인플루엔자 HA 항체이고 WO2008/028946에서는 CR6261로도 불린다.
마우스 및 NHP PK 실험 둘 다를 위해서, ELISA 면역검정을 사용한 전체 인간 항체 분석에 의해 순환 약물 수준을 결정하였다. 간략히 말하면, 염소 항-인간 IgG 다클론성 항체를 96-웰 플레이트에 코팅하여 혈청에서 테스트된 인간 항체를 캡쳐한 다음, 플레이트에 결합된 항체를 홀스래디쉬 및 TMB 기질과 컨쥬게이션된 염소 항-인간 IgG 다클론성 항체를 사용하여 검출하였다. 혈청 샘플을 6회-용량 단계 희석하였고 각 항체의 참조 표준을 12회-용량 단계 희석하였다. Graphpad Prism 소프트웨어를 사용하여 생성된 참조 표준 곡선에 기초하여 혈청 내 약물 항체 농도를 계산하였다.
A. 마우스 연구
야생형 (WT) C57BL/6 마우스에서 H1H11729P의 약동학적 평가를 실행하였다. H1H11729P 및 Control I mAb를 5마리 마우스의 별도의 군에 각각 1 mg/kg의 용량으로 SC 투여하였다. 항체 주사 전 (채혈 전) 1일 전에 혈액을 수거했을 뿐 아니라 주사 후 6h, 1일, 2일, 3일, 4일, 7일, 11일, 14일, 22일, 및 30일에 혈액을 수거하였다. 혈액으로부터 혈청 분획을 분리하였고 분석이 실행될 때까지 -80 ℃에서 냉동시켰다.
결과:
표 14에서 나타난 바와 같이, WT 마우스에서 H1H11729P의 반감기는 11.1일인 한편, Control I mAb의 반감기는 5.67일이었으며, 비교기 항체보다 H1H11729P의 유리한 성질을 나타낸다.
미감염 야생형 마우스에서 H1H11729P 및 Control I mAb의 약동학적 프로파일의 요약
약물 T1/2 (d) Cmax (μ/mL) AUC(d* μ /mL)
H1H11729P 11.1 ± 0.8 12.0 ± 0.9 147 ± 3.4
Control I mAb 5.67 ± 0.6 10.4 ± 0.6 93.8 ± 4.8
B. 게먹이 원숭이(Cynomolgus) NHP
H1H11729P 및 Control I mAb의 약동학적 클리어런스(clearance) 율의 평가를 3-5연령, 암컷 게먹이 원숭이에서 실행하였다. 원숭이를 인플루엔자 A 및 B 항체에 대하여 사전 스크리닝하였고 음성인 것을 발견하였다. 항체를 세 마리 동물에서 테스트하였고 3 mg/kg의 용량으로 (2 mL/kg 및 1.5 mg/mL의 부피로) 피하로 투여하였다. 혈액 샘플을 투여 전에 및 주사 후 1h, 4h, 8h, 및 1일, 2일, 3일, 4일, 5일, 10일, 14일, 18일, 21일, 24일, 28일, 35일, 42일, 49일, 56일, 63일, 70일, 84일, 및 98일에 수거하였다. 혈청을 전혈로부터 분리하였고 분석할 때까지 -80 ℃에서 냉동시켰다. ELISA 면역검정을 사용한 전체 인간 항체 분석에 의해 순환 약물 농도를 결정하였다. Graphpad Prism 소프트웨어를 사용하여 생성된 참조 표준 곡선에 기초하여 혈청 내 약물 항체 농도를 계산하였다.
결과:
표 15에서 나타난 바와 같이, 원숭이에서 H1H11729P의 반감기는 13.4일인 한편, Control I mAb의 반감기는 8.05일이었으며, 비교기 항체와 비교하여 H1H11729P의 유리한 성질을 나타낸다.
게먹이 원숭이에서 H1H11729P 및 Control I mAb의 약동학적 프로파일의 요약
약물 T1/2 (d) Cmax (μg/mL) AUC(d* μg /mL)
H1H11729P 13.4 ± 1.46 41.3 ± 7.84 863 ± 145
Control I mAb 8.05 ± 2.17 24.9 ± 1.87 320 ± 70.1
실시예 10: H1H11729P는 마우스에서 치명적인 인플루엔자 바이러스 감염을 효과적으로 치료한다.
인간에서 인플루엔자 바이러스 감염을 치료하거나 예방하기 위한 관리 요법의 개선된 기준에 대한 요구는 실질적으로 충족되지 않는다. 현재, 단지 두 부류의 약물만이 이용 가능하다: 아다만탄 및 뉴라미니다제 억제자 (NAI). 아다만탄 (아만타딘 및 리만타딘)은 약물-저항성 균주의 급속한 출현과 관련되어 있으며 더 이상 인플루엔자의 치료에 권장되지 않는다. 오셀타미비르 (Tamiflu®)와 같은 NAI는 인플루엔자의 치료 및 예방을 위해 우수한 약물이지만, 그것들의 효능의 창은 제한된다: NAI는 치료적 설정에서 증상 시작 48시간 이내에 항바이러스제가 투여된 경우 열 및 질환 증상의 기간을 약 1일 만큼 감소시키는 것으로 나타났으며 48시간 이후 투여된 경우에는 효험에 대한 임상적 증거가 거의 없다.
중증 인플루엔자의 치료시 H1H11729P의 생체 내 효험을 평가하기 위해서, 다음의 목적으로 실험을 시행하였다:
연구 1: 5일 동안 1일 2회 제공된 관리 오셀타미비르 (Tamiflu®)의 임상 표준에 대하여 H1H11729P의 1회 용량의 효험을 평가하기 위해서.
연구 2: 오셀타미비르와 함께 투여된 H1H11729P의 효험을 결정하기 위해서.
이 연구들에 사용된 균주는 과거의 [A/Puerto Rico/08/1934 (H1N1)] 인플루엔자 A 바이러스 1군 분리체를 포함하였다. 모든 실험을 6주령 야생형 (BALB/c) 암컷 마우스에서 수행하였다. 마우스를 A/Puerto Rico/08/1934 (H1N1)의 800개의 플라크-형성 단위 (PFU)와 동등한 10 x 마우스 LD50 (MLD50)으로 공격접종하였다. 치료 모델에서, 마우스를 감염 후 (p.i.) 제0 일에 비강 내로 (IN) 공격접종하였고 고정된 용량의 mAb를 감염 후 특정 일 (예를 들어, 제1 일, 제2 일, 제3 일, 제4 일 또는 제5 일)에 정맥 내로 (IV) 제공하였다. 오셀타미비르를 제조사의 지시에 따라 재현탁하였고 마우스를 5일 동안 경구 위관 영양법을 통해 12 h마다(즉, 1일 2회; BID) 투여하였으며, 최초 용량을 감염 후 제2 일 또는 제3 일에 투여하였다. 마우스의 체중을 측정하였고 p.i. 제14 일까지 매일 관찰하였으며 시작 체중의 20%가 손실되었을 때 희생시켰다. 결과는 퍼센트 생존률로서 보고된다.
첫 번째 실험에서 감염 후 48시간에 시작하는 (즉, 치료적으로 투여됨) H1H11729P (15 mg/kg)의 1회 용량 또는 오셀타미비르 25 또는 5 mg/kg BID (5일 양생법)의 효험을 연구하여 쥐 모델에서 이 시점에서의 효과를 평가하였다. 5 mg/kg 오셀타미비르를 받은 모든 마우스들은 제6 일에 사망하는 한편, 25 mg/kg의 용량은 생존률을 40%로 개선하였다; 그에 반해, H1H11729P를 받은 모든 마우스가 생존하였다 (도 1 및 표 16).
다음 실험에서는, H1H11729P를 오셀타미비르와 조합하여 테스트하였으며, 감염 후 72시간에 시작하였다. 25 mg/kg 오셀타미비르가 처리된 마우스의 대략 20%만이 생존하는 한편, 15 mg/kg 및 7 mg/kg으로 H1H11729P의 1회 용량은 각각 60% 및 36% 생존률을 초래하였다. 치료가 조합되었을 때 부가 효과가 관찰되었다: 오셀타미비르의 양생법과 조합된 7 mg/kg H1H11729P의 1회 용량은 60% 생존률을 나타냈고 오셀타미비르의 양생법과 조합하여 15 mg/kg H1H11729P의 1회 용량은 87% 생존률을 초래하였다 (도 2 및 표 17).
요약하면, H1H11729P는 중증 과거의 인플루엔자 균주로 감염된 마우스를 치료하는데 있어서 강력한 효험을 나타냈으며, 실제로, 감염 후 48시간에 오셀타미비르보다 더 큰 효험을 나타냈다. 게다가, H1H11729P는 오셀타미비르와 조합하여 투여될 때 부가 효험을 나타냈다.
연구 1의 결과: 마우스에서 중증 인플루엔자 A 바이러스 감염을 치료하는데 있어서 p.i. 48시간에 H1H11729P의 1회 용량은 p.i. 48시간에 오셀타미비르보다 더 큰 효험을 나타낸다.
PID 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수)
경구 위관 영양법 대조군 (미감염) 5 100 (5/5)
H1H11729P 5 100 (5/5)
오셀타미비르 (25 mg/kg BID x 5d) 5 40 (2/5)
오셀타미비르 (5 mg/kg BID x 5d) 5 0 (0/5)
hIgG1 음성 아이소타입 대조군 5 0 (0/5)
경구 위관 영양법 대조군 (감염) 5 0 (0/5)
연구 2의 결과: 마우스에서 중증 인플루엔자를 치료하기 위해서 p.i. 72시간에 H1H11729P의 1회 용량이 오셀타미비르와 조합될 때 부가 효험이 관찰된다.
PID 군 당 마우스의 수 퍼센트 생존률 (각 군에서 생존한 마우스의 수/마우스의 총 수)
H1H11729P (15 mg/kg) 15 60 (9/15)
H1H11729P (7 mg/kg) 15 35.7 (5/15)
H1H11729P (15 mg/kg) + 오셀타미비르 (25 mg/kg BID x 5d) 15 86.7 (13/15)
H1H11729P (7 mg/kg) + 오셀타미비르 (25 mg/kg BID x 5d) 15 60 (9/15)
오셀타미비르 (25 mg/kg BID x 5 d) 15 20 (3/15)
hIgG1 음성 아이소타입 대조군 15 0 (0/15)
경구 위관 영양법 대조군 (감염) 15 0 (0/15)
SEQUENCE LISTING <110> Regeneron Pharmaceuticals, Inc. <120> Human Antibodies to Influenza Hemagglutinin <130> 10119WO01 <150> 62/094752 <151> 2014-12-19 <150> 62/152122 <151> 2015-04-24 <160> 6328 <170> FastSEQ for Windows Version 4.0 <210> 1 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc aactatgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagag gatgggaggg atcatcccta tctttggtac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240 atggagctgg gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggaag 300 gatttctatg gttcggggag ttattataac ctctttgact actggggcca gggaaccctg 360 gtcaccgtct cctca 375 <210> 2 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Arg Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Gly Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Lys Asp Phe Tyr Gly Ser Gly Ser Tyr Tyr Asn Leu Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3 ggaggcacct tcagcaacta tgct 24 <210> 4 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4 Gly Gly Thr Phe Ser Asn Tyr Ala 1 5 <210> 5 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5 atcatcccta tctttggtac agca 24 <210> 6 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 7 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 7 gcgagaggga aggatttcta tggttcgggg agttattata acctctttga ctac 54 <210> 8 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 8 Ala Arg Gly Lys Asp Phe Tyr Gly Ser Gly Ser Tyr Tyr Asn Leu Phe 1 5 10 15 Asp Tyr <210> 9 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 9 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga catagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttttta ctgccaacac tataatactt attcgtggac gttcggccaa 300 gggaccaagg tggaaatcaa a 321 <210> 10 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 10 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Ile Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Phe Tyr Cys Gln His Tyr Asn Thr Tyr Ser Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 11 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 11 cagagtatta gtagctgg 18 <210> 12 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 12 Gln Ser Ile Ser Ser Trp 1 5 <210> 13 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 13 aaggcgtct 9 <210> 14 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 14 Lys Ala Ser 1 <210> 15 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 15 caacactata atacttattc gtggacg 27 <210> 16 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 16 Gln His Tyr Asn Thr Tyr Ser Trp Thr 1 5 <210> 17 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 17 caggtgcagc tggtgcagtc tggggctgag gtgaagaagt ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc agctatgcta ttagctgggt gcgccaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tttttggtac accaagctat 180 gcacagaagt tccaggacag agtcacgatt accacggacg aatccacgag cacagtttac 240 atggagctga gcagcctgag atctgaagac acggccgtgt attactgtgc gagacagcag 300 cccgtctacc agtacaatat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 18 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 18 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Gln Pro Val Tyr Gln Tyr Asn Met Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 19 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 19 ggaggcacct tcagcagcta tgct 24 <210> 20 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 20 Gly Gly Thr Phe Ser Ser Tyr Ala 1 5 <210> 21 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 21 atcatcccta tttttggtac acca 24 <210> 22 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 22 Ile Ile Pro Ile Phe Gly Thr Pro 1 5 <210> 23 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 23 gcgagacagc agcccgtcta ccagtacaat atggacgtc 39 <210> 24 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 24 Ala Arg Gln Gln Pro Val Tyr Gln Tyr Asn Met Asp Val 1 5 10 <210> 25 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 25 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aataatttag gctggtatca gcagaaacca 120 ctgaaagccc ctaagcgcct gatctatgct gcgtccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa tataataatt acccgtggac gttcggccaa 300 gggaccaagg tggaaatcaa a 321 <210> 26 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 26 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asn 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Leu Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asn Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 27 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 27 cagggcatta gaaataat 18 <210> 28 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 28 Gln Gly Ile Arg Asn Asn 1 5 <210> 29 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 29 gctgcgtcc 9 <210> 30 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 30 Ala Ala Ser 1 <210> 31 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 31 ctacaatata ataattaccc gtggacg 27 <210> 32 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 32 Leu Gln Tyr Asn Asn Tyr Pro Trp Thr 1 5 <210> 33 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 33 caggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcaac agctatgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggc atcatcccta tctttgctac aacaaacttc 180 gcacagaagt tccagggcag agtcacgatt acctcggacg aatccacgaa cacagcctac 240 atggagctga ccagcctgag atctgaggac acggccgcgt attactgtgc aagggggggt 300 tggtataact ggcagtacgt ggggtttgac tcctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 34 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 34 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Ala Thr Thr Asn Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ser Asp Glu Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Ala Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Trp Tyr Asn Trp Gln Tyr Val Gly Phe Asp Ser Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 35 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 35 ggaggcacct tcaacagcta tgct 24 <210> 36 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 36 Gly Gly Thr Phe Asn Ser Tyr Ala 1 5 <210> 37 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 37 atcatcccta tctttgctac aaca 24 <210> 38 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 38 Ile Ile Pro Ile Phe Ala Thr Thr 1 5 <210> 39 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 39 gcaagggggg gttggtataa ctggcagtac gtggggtttg actcc 45 <210> 40 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 40 Ala Arg Gly Gly Trp Tyr Asn Trp Gln Tyr Val Gly Phe Asp Ser 1 5 10 15 <210> 41 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 41 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcgcc 60 atcacttgcc gggccagtca gagtattagt acctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaaatgg ggtcccttca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcaggct 240 gatgattttg caacttatta ctgccaaaag tataatagta attcgtggac gttcggccaa 300 gggaccaagg tggatatcaa a 321 <210> 42 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 42 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Asn Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Asn Ser Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 43 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 43 cagagtatta gtacctgg 18 <210> 44 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 44 Gln Ser Ile Ser Thr Trp 1 5 <210> 45 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 45 aaggcgtct 9 <210> 46 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 46 Lys Ala Ser 1 <210> 47 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 47 caaaagtata atagtaattc gtggacg 27 <210> 48 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 48 Gln Lys Tyr Asn Ser Asn Ser Trp Thr 1 5 <210> 49 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 49 caggtccacc tggtgcagtc tgggccagag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagt caccttcatc agtcatgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgaatg ggtgggagga atcatcgcta tctttggtac aacaaactac 180 gcacagaagt tccagggcag agtcacggtt acaacggaca aatccacgaa cacagtctac 240 atggaattga gcagactgag atctgaggac acggccattt attactgtgc gcgaggtgag 300 acctactacg agggaaactt tgacttctgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 50 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 50 Gln Val His Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Phe Ile Ser His 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly Ile Ile Ala Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Val Thr Thr Asp Lys Ser Thr Asn Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Glu Thr Tyr Tyr Glu Gly Asn Phe Asp Phe Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 51 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 51 ggagtcacct tcatcagtca tgct 24 <210> 52 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 52 Gly Val Thr Phe Ile Ser His Ala 1 5 <210> 53 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 53 atcatcgcta tctttggtac aaca 24 <210> 54 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 54 Ile Ile Ala Ile Phe Gly Thr Thr 1 5 <210> 55 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 55 gcgcgaggtg agacctacta cgagggaaac tttgacttc 39 <210> 56 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 56 Ala Arg Gly Glu Thr Tyr Tyr Glu Gly Asn Phe Asp Phe 1 5 10 <210> 57 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 57 gtcatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagcgttagg agtaatttaa attggtatca gcagacacca 120 gggaaagccc ctaggctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttatta ctgtcaacag agttacagta cccctccgat caccttcggc 300 caagggacac gactggagat taaa 324 <210> 58 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 58 Val Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 20 25 30 Leu Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 59 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 59 cagagcgtta ggagtaat 18 <210> 60 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 60 Gln Ser Val Arg Ser Asn 1 5 <210> 61 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 61 gctgcatcc 9 <210> 62 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 62 Ala Ala Ser 1 <210> 63 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 63 caacagagtt acagtacccc tccgatcacc 30 <210> 64 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 64 Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 1 5 10 <210> 65 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 65 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc 300 caagggacac gactggagat taaa 324 <210> 66 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 66 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 67 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 67 cagagcatta gcagctat 18 <210> 68 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 68 Gln Ser Ile Ser Ser Tyr 1 5 <210> 69 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 69 gctgcatcc 9 <210> 70 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 70 Ala Ala Ser 1 <210> 71 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 71 caacagagtt acagtacccc tccgatcacc 30 <210> 72 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 72 Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 1 5 10 <210> 73 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 73 caggtgcagc tggtgcagtc tggagcagag gtgaggaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg aaccttcacc ggccatgcta tcagctgggt gcgacaggcc 120 cctggacaag gccttgagtg gatgggaggg gtcgtcccta tctttggttc agcaaactac 180 gcacagaagt tccagggcag agtcacgatg accatggacg aatccacgag tacagcctac 240 atggacctga gcagcctgag atctgaggac acggccgttt attattgtgt gagagatccg 300 ggcaactcgg gatactacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 74 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 74 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Gly His 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Val Pro Ile Phe Gly Ser Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Met Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg Asp Pro Gly Asn Ser Gly Tyr Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 75 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 75 ggaggaacct tcaccggcca tgct 24 <210> 76 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 76 Gly Gly Thr Phe Thr Gly His Ala 1 5 <210> 77 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 77 gtcgtcccta tctttggttc agca 24 <210> 78 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 78 Val Val Pro Ile Phe Gly Ser Ala 1 5 <210> 79 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 79 gtgagagatc cgggcaactc gggatactac tactacggta tggacgtc 48 <210> 80 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 80 Val Arg Asp Pro Gly Asn Ser Gly Tyr Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 81 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 81 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtttca gcagaaacca 120 gggaaagccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagtt cccctccgat caccttcggc 300 caagggacac gactggagat taaa 324 <210> 82 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 82 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 83 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 83 cagagcatta gcagctat 18 <210> 84 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 84 Gln Ser Ile Ser Ser Tyr 1 5 <210> 85 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 85 actgcatcc 9 <210> 86 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 86 Thr Ala Ser 1 <210> 87 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 87 caacagagtt acagttcccc tccgatcacc 30 <210> 88 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 88 Gln Gln Ser Tyr Ser Ser Pro Pro Ile Thr 1 5 10 <210> 89 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 89 caggtccacc tggtgcagtc tggggctgag gtgaagaagc ctgggtcgtc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc acctatgcta tcacctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gataggaggg atcagccgtt tctttggttc agcaaactac 180 gcacagaagt ttcagggcag agtcacaatt accacggacg aatccacgaa cacagcctac 240 atggaactaa gcagcctgag atctgaggac acggccgtat attattgtgc gagagatcct 300 ggaaacacgg gctattattt ttacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 90 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 90 Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 20 25 30 Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Arg Phe Phe Gly Ser Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Gly Asn Thr Gly Tyr Tyr Phe Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 91 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 91 ggaggcacct tcagcaccta tgct 24 <210> 92 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 92 Gly Gly Thr Phe Ser Thr Tyr Ala 1 5 <210> 93 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 93 atcagccgtt tctttggttc agca 24 <210> 94 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 94 Ile Ser Arg Phe Phe Gly Ser Ala 1 5 <210> 95 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 95 gcgagagatc ctggaaacac gggctattat ttttacggta tggacgtc 48 <210> 96 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 96 Ala Arg Asp Pro Gly Asn Thr Gly Tyr Tyr Phe Tyr Gly Met Asp Val 1 5 10 15 <210> 97 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 97 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agtaagagta attctccgat caccttcggc 300 caagggacac gactggagat taaa 324 <210> 98 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 98 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Ser Asn Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 99 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 99 cagagcatta gcagctat 18 <210> 100 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 100 Gln Ser Ile Ser Ser Tyr 1 5 <210> 101 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 101 ggtgcatcc 9 <210> 102 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 102 Gly Ala Ser 1 <210> 103 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 103 caacagagta agagtaattc tccgatcacc 30 <210> 104 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 104 Gln Gln Ser Lys Ser Asn Ser Pro Ile Thr 1 5 10 <210> 105 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 105 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcatc acctatgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggt gtcatcccta tctttggtac tccaaggtac 180 gcacagaagt tccagggcag agtcacgatt accacggacg attccacgac cacagcctac 240 atggagctga gcagcctgag atctgacgac acggccgtgt attattgtgc gacaaggagc 300 agctcgtctc cctattatta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 106 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 106 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Thr Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Val Ile Pro Ile Phe Gly Thr Pro Arg Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Asp Ser Thr Thr Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Arg Ser Ser Ser Ser Pro Tyr Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 107 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 107 ggaggcacct tcatcaccta tgct 24 <210> 108 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 108 Gly Gly Thr Phe Ile Thr Tyr Ala 1 5 <210> 109 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 109 gtcatcccta tctttggtac tcca 24 <210> 110 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 110 Val Ile Pro Ile Phe Gly Thr Pro 1 5 <210> 111 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 111 gcgacaagga gcagctcgtc tccctattat tactacggta tggacgtc 48 <210> 112 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 112 Ala Thr Arg Ser Ser Ser Ser Pro Tyr Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 113 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 113 gatattgtga tgacccagac tccactctcc tcacctgtca cccttggaca gccggcctcc 60 atctcctgca ggtctagtca aagcctcgta cacagtgatg gaaacaccta tttgagttgg 120 cttcagcaga ggccaggcca gcctccaaga ctcctaattt ataagatttc taaccggttc 180 tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc 240 agcagggtgg aagctgagga tgtcgggatt tattactgca ttcaagctac acaatttccg 300 tacacttttg gccaggggac caagctggag atcaaa 336 <210> 114 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 114 Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 35 40 45 Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ile Gln Ala 85 90 95 Thr Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 115 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 115 caaagcctcg tacacagtga tggaaacacc tat 33 <210> 116 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 116 Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 1 5 10 <210> 117 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 117 aagatttct 9 <210> 118 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 118 Lys Ile Ser 1 <210> 119 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 119 attcaagcta cacaatttcc gtacact 27 <210> 120 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 120 Ile Gln Ala Thr Gln Phe Pro Tyr Thr 1 5 <210> 121 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 121 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgacggtc 60 tcctgcaagg cttctggata caccttcacc aattatgata tcaactgggt gcgacaggcc 120 actggacaag gacttgagtg gttgggatgg atgagcccta acagtggtaa caaaggctat 180 gcacagaagt tccagggcag agtctccatg actttgaata ccgccttaag cacagcctac 240 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatggtat 300 tgtagtgatg ccagttgcta tcccgatgct tttgatatct ggggccaagg gacaatggtc 360 accgtctctt ca 372 <210> 122 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 122 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Trp Met Ser Pro Asn Ser Gly Asn Lys Gly Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Ser Met Thr Leu Asn Thr Ala Leu Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Tyr Cys Ser Asp Ala Ser Cys Tyr Pro Asp Ala Phe Asp 100 105 110 Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 123 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 123 ggatacacct tcaccaatta tgat 24 <210> 124 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 124 Gly Tyr Thr Phe Thr Asn Tyr Asp 1 5 <210> 125 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 125 atgagcccta acagtggtaa caaa 24 <210> 126 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 126 Met Ser Pro Asn Ser Gly Asn Lys 1 5 <210> 127 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 127 gcgagatggt attgtagtga tgccagttgc tatcccgatg cttttgatat c 51 <210> 128 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 128 Ala Arg Trp Tyr Cys Ser Asp Ala Ser Cys Tyr Pro Asp Ala Phe Asp 1 5 10 15 Ile <210> 129 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 129 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca ggatttttcc gactggttag cctggtatca gcagaaacct 120 gggaaagccc ctgagctcct gatctatgct acatccagtt tgcatactgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcac cctgcagcct 240 gaagattttg ctacttacta ttgtctacag gctaacaatt tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa a 321 <210> 130 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 130 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Phe Ser Asp Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ala Asn Asn Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 131 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 131 caggattttt ccgactgg 18 <210> 132 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 132 Gln Asp Phe Ser Asp Trp 1 5 <210> 133 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 133 gctacatcc 9 <210> 134 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 134 Ala Thr Ser 1 <210> 135 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 135 ctacaggcta acaatttccc gctcact 27 <210> 136 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 136 Leu Gln Ala Asn Asn Phe Pro Leu Thr 1 5 <210> 137 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 137 caggtgcagc tggtggagtc tgggggaggc gtggcccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggaat caccttcaat aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcattt atttcagatg aaggaagaaa taaacactat 180 ggagactccg tgaagggccg attcaccatc gacagagaca attccaagaa cacactgtat 240 ctgcaaatga atagcctgag agctgaggac acggctgtat attactgtgc gaaattgggg 300 gataatagga atcaccacta cggtttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 138 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 138 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Ala Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asn Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Asp Glu Gly Arg Asn Lys His Tyr Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Asp Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Asp Asn Arg Asn His His Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 139 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 139 ggaatcacct tcaataacta tggc 24 <210> 140 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 140 Gly Ile Thr Phe Asn Asn Tyr Gly 1 5 <210> 141 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 141 atttcagatg aaggaagaaa taaa 24 <210> 142 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 142 Ile Ser Asp Glu Gly Arg Asn Lys 1 5 <210> 143 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 143 gcgaaattgg gggataatag gaatcaccac tacggtttgg acgtc 45 <210> 144 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 144 Ala Lys Leu Gly Asp Asn Arg Asn His His Tyr Gly Leu Asp Val 1 5 10 15 <210> 145 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 145 gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca gggcattacc aattatttag cctggtatca gcaaaaacca 120 gggaaagccc ctagcctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggaca tgggacagaa ttcactctca cagtcagcag cctgcagcct 240 gaagattttg taacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa 300 gggacacgac tggagattaa a 321 <210> 146 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 146 Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Thr Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Ser Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly His Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Val Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 147 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 147 cagggcatta ccaattat 18 <210> 148 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 148 Gln Gly Ile Thr Asn Tyr 1 5 <210> 149 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 149 gctgcatcc 9 <210> 150 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 150 Ala Ala Ser 1 <210> 151 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 151 caacagttta atagttaccc gatcacc 27 <210> 152 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 152 Gln Gln Phe Asn Ser Tyr Pro Ile Thr 1 5 <210> 153 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 153 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgtaagg cttctggagg caccttcagc aactatgata tcagctgggt gcgacaggcc 120 cctggacaag gacttgagtg gatgggaggg atcatcccca tcattggtac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt acaacggacg aatccacgag cacagcctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatccg 300 ggtatagcag tggctggttc gagctttgac tactggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 154 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 154 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Ile Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Gly Ile Ala Val Ala Gly Ser Ser Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 155 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 155 ggaggcacct tcagcaacta tgat 24 <210> 156 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 156 Gly Gly Thr Phe Ser Asn Tyr Asp 1 5 <210> 157 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 157 atcatcccca tcattggtac agca 24 <210> 158 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 158 Ile Ile Pro Ile Ile Gly Thr Ala 1 5 <210> 159 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 159 gcgagagatc cgggtatagc agtggctggt tcgagctttg actac 45 <210> 160 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 160 Ala Arg Asp Pro Gly Ile Ala Val Ala Gly Ser Ser Phe Asp Tyr 1 5 10 15 <210> 161 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 161 gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga catgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccaatt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt accctcggac gttcggccaa 300 gggaccaagg tggaaatcaa a 321 <210> 162 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 162 Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg His Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 163 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 163 cagggcatta gacatgat 18 <210> 164 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 164 Gln Gly Ile Arg His Asp 1 5 <210> 165 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 165 gctgcatcc 9 <210> 166 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 166 Ala Ala Ser 1 <210> 167 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 167 ctacaagatt acaattaccc tcggacg 27 <210> 168 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 168 Leu Gln Asp Tyr Asn Tyr Pro Arg Thr 1 5 <210> 169 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 169 caggtgcagc tggtgcagtc tggggctgag gtgaggacgc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc agctatgctg tcacctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg ctcatccctt tctttggtcc agcaaactac 180 gcacagagat tccagggcag agtctcgatt accacggacg aatccacgaa catagcctac 240 ttggagctga gcagcctgag atccgaggac tcggccgttt attactgtgc gagagggcgg 300 aacttcggtg actactgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 170 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 170 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Val Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Leu Ile Pro Phe Phe Gly Pro Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Gln Gly Arg Val Ser Ile Thr Thr Asp Glu Ser Thr Asn Ile Ala Tyr 65 70 75 80 Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Asn Phe Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 171 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 171 ggaggcacct tcagcagcta tgct 24 <210> 172 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 172 Gly Gly Thr Phe Ser Ser Tyr Ala 1 5 <210> 173 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 173 ctcatccctt tctttggtcc agca 24 <210> 174 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 174 Leu Ile Pro Phe Phe Gly Pro Ala 1 5 <210> 175 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 175 gcgagagggc ggaacttcgg tgactac 27 <210> 176 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 176 Ala Arg Gly Arg Asn Phe Gly Asp Tyr 1 5 <210> 177 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 177 gacatccaga tgacccagtc tccatcctca ctgtctgcat ctataggaga cagagtcacc 60 atcacttgtc gggcgagtca ggacattagc aattatttag cctggtttca gcagaaacca 120 gggaaagtcc ctaagtccct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca 180 aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagtac cctgcagcct 240 gaagattttg caacttatta ctgccaacag tatagtagtt atccattcac tttcggccct 300 gggaccaaag tggatatcaa a 321 <210> 178 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 178 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Ser Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 179 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 179 caggacatta gcaattat 18 <210> 180 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 180 Gln Asp Ile Ser Asn Tyr 1 5 <210> 181 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 181 gctgcatcc 9 <210> 182 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 182 Ala Ala Ser 1 <210> 183 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 183 caacagtata gtagttatcc attcact 27 <210> 184 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 184 Gln Gln Tyr Ser Ser Tyr Pro Phe Thr 1 5 <210> 185 <211> 351 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 185 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaactac 180 gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaaggcac 300 ggtatatcct ttgactactg gggccaggga accctggtca ccgtctcctc a 351 <210> 186 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 186 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg His Gly Ile Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 187 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 187 ggaggcacct tcagcagcta tgct 24 <210> 188 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 188 Gly Gly Thr Phe Ser Ser Tyr Ala 1 5 <210> 189 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 189 atcatcccta tctttggtac aaca 24 <210> 190 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 190 Ile Ile Pro Ile Phe Gly Thr Thr 1 5 <210> 191 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 191 gcgagaaggc acggtatatc ctttgactac 30 <210> 192 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 192 Ala Arg Arg His Gly Ile Ser Phe Asp Tyr 1 5 10 <210> 193 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 193 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 gtcacttgcc gggcaagtca gggcattaga aatgatttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacag cataatagtt atccgtggac gttcggccta 300 gggaccaagg tggaaatcaa a 321 <210> 194 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 194 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 85 90 95 Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys 100 105 <210> 195 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 195 cagggcatta gaaatgat 18 <210> 196 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 196 Gln Gly Ile Arg Asn Asp 1 5 <210> 197 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 197 gctgcatcc 9 <210> 198 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 198 Ala Ala Ser 1 <210> 199 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 199 ctacagcata atagttatcc gtggacg 27 <210> 200 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 200 Leu Gln His Asn Ser Tyr Pro Trp Thr 1 5 <210> 201 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 201 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt tcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcagcccta tctttggtac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagagtcc 300 ccgtataact ggaaccaaaa atacttccag tattggggcc agggcaccct ggtcaccgtc 360 tcctca 366 <210> 202 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 202 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ser Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ser Pro Tyr Asn Trp Asn Gln Lys Tyr Phe Gln Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 203 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 203 ggaggcacct tcagcagcta tact 24 <210> 204 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 204 Gly Gly Thr Phe Ser Ser Tyr Thr 1 5 <210> 205 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 205 atcagcccta tctttggtac agca 24 <210> 206 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 206 Ile Ser Pro Ile Phe Gly Thr Ala 1 5 <210> 207 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 207 gcgagagagt ccccgtataa ctggaaccaa aaatacttcc agtat 45 <210> 208 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 208 Ala Arg Glu Ser Pro Tyr Asn Trp Asn Gln Lys Tyr Phe Gln Tyr 1 5 10 15 <210> 209 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 209 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attcgtacac ttttggccag 300 gggaccaagc tggagatcaa a 321 <210> 210 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 210 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 211 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 211 cagagtatta gtagctgg 18 <210> 212 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 212 Gln Ser Ile Ser Ser Trp 1 5 <210> 213 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 213 aaggcgtct 9 <210> 214 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 214 Lys Ala Ser 1 <210> 215 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 215 caacagtata atagttattc gtacact 27 <210> 216 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 216 Gln Gln Tyr Asn Ser Tyr Ser Tyr Thr 1 5 <210> 217 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 217 caggtccagc tggtgcagtc tgggtctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cgtctggagg gaccctcagc ctctatgctg tcagctgggt gcgacaggcc 120 cctggacagg ggcttgagtg gatggggggg atcatcccta tctttggtac aacaaaatac 180 gcacaggagt tccagggcag agtcacgttt tccacggacg agtccacgag cacagcctac 240 atggagctga acagcctgcg atctgaggac acggccgtgt attactgtgc gagacaatgg 300 actatgacta gaaccttgga ttttgacatc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 218 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 218 Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Leu Tyr 20 25 30 Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Lys Tyr Ala Gln Glu Phe 50 55 60 Gln Gly Arg Val Thr Phe Ser Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Trp Thr Met Thr Arg Thr Leu Asp Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 219 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 219 ggagggaccc tcagcctcta tgct 24 <210> 220 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 220 Gly Gly Thr Leu Ser Leu Tyr Ala 1 5 <210> 221 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 221 atcatcccta tctttggtac aaca 24 <210> 222 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 222 Ile Ile Pro Ile Phe Gly Thr Thr 1 5 <210> 223 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 223 gcgagacaat ggactatgac tagaaccttg gattttgaca tc 42 <210> 224 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 224 Ala Arg Gln Trp Thr Met Thr Arg Thr Leu Asp Phe Asp Ile 1 5 10 <210> 225 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 225 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc ggacaagtca gggcattaga aatgatttag gctggtatca gcagaaaccg 120 gggaaagccc ctaagcgcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca 180 agattcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caagttatta ctgtctacaa cataataatt atccgtggac gttcggccaa 300 gggaccaagg tggaaatcaa a 321 <210> 226 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 226 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ser Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 227 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 227 cagggcatta gaaatgat 18 <210> 228 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 228 Gln Gly Ile Arg Asn Asp 1 5 <210> 229 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 229 ggtgcatcc 9 <210> 230 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 230 Gly Ala Ser 1 <210> 231 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 231 ctacaacata ataattatcc gtggacg 27 <210> 232 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 232 Leu Gln His Asn Asn Tyr Pro Trp Thr 1 5 <210> 233 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 233 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgtag cctccggatt caccttcagt gtctatggca tgaactgggt ccgccaggct 120 ccaggcaagg gtctggactg ggtggcagtc atatcaaatg atggaagtta taaatactat 180 gcggactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat 240 ctgcaaatga acagcctgag aggtgaggac acggctattt attactgtgc gaaaaggaat 300 gaatgggagc tagaggaata ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 234 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 234 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Val Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 Ala Val Ile Ser Asn Asp Gly Ser Tyr Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Lys Arg Asn Glu Trp Glu Leu Glu Glu Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 235 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 235 ggattcacct tcagtgtcta tggc 24 <210> 236 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 236 Gly Phe Thr Phe Ser Val Tyr Gly 1 5 <210> 237 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 237 atatcaaatg atggaagtta taaa 24 <210> 238 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 238 Ile Ser Asn Asp Gly Ser Tyr Lys 1 5 <210> 239 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 239 gcgaaaagga atgaatggga gctagaggaa tactacggta tggacgtc 48 <210> 240 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 240 Ala Lys Arg Asn Glu Trp Glu Leu Glu Glu Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 241 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 241 gaggtgcagc tggtggagtc tgggggagga ttggtacagt ctggagggtc cctgagactc 60 tcctgtgtag cctctggatt caccttcaat aattatgaga tgaattgggt ccgccaggct 120 ccagggaagg ggctggagtg gatttcatac attgatatta atggtggaag taccatctac 180 tatgcagact ctgtgaaggg ccgattcacc atctccagag acaatgccaa gaagtcactg 240 tatctgcaaa tgaacagcct gagagccgag gacacggcta tttactactg tgcgagcgcc 300 tttggttcgg gtggttttct ttttgactat tggggccagg gaaccctggt cactgtctcc 360 tca 363 <210> 242 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 242 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asn Tyr 20 25 30 Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ser Tyr Ile Asp Ile Asn Gly Gly Ser Thr Ile Tyr Tyr Ala Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 85 90 95 Cys Ala Ser Ala Phe Gly Ser Gly Gly Phe Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 243 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 243 ggattcacct tcaataatta tgag 24 <210> 244 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 244 Gly Phe Thr Phe Asn Asn Tyr Glu 1 5 <210> 245 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 245 attgatatta atggtggaag taccatc 27 <210> 246 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 246 Ile Asp Ile Asn Gly Gly Ser Thr Ile 1 5 <210> 247 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 247 gcgagcgcct ttggttcggg tggttttctt tttgactat 39 <210> 248 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 248 Ala Ser Ala Phe Gly Ser Gly Gly Phe Leu Phe Asp Tyr 1 5 10 <210> 249 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 249 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggatgtc cctgagactc 60 tcctgtatag cgtctggatt caccttcagt gactatgtca tacactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcaatt atatggtatg atggaagtaa taaatactat 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 cttgaaatga atagactgag agtcgaggac acggctgtgt tttactgtgc gaggggtctg 300 gggatcgaag attacaatta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 250 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 250 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Met 1 5 10 15 Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Val Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Glu Met Asn Arg Leu Arg Val Glu Asp Thr Ala Val Phe Tyr Cys 85 90 95 Ala Arg Gly Leu Gly Ile Glu Asp Tyr Asn Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 251 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 251 ggattcacct tcagtgacta tgtc 24 <210> 252 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 252 Gly Phe Thr Phe Ser Asp Tyr Val 1 5 <210> 253 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 253 atatggtatg atggaagtaa taaa 24 <210> 254 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 254 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 255 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 255 gcgaggggtc tggggatcga agattacaat tacggtatgg acgtc 45 <210> 256 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 256 Ala Arg Gly Leu Gly Ile Glu Asp Tyr Asn Tyr Gly Met Asp Val 1 5 10 15 <210> 257 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 257 gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacactgg 300 accgacgagg atgcttttga tatctggggc caagggacaa tggtcaccgt ctcttca 357 <210> 258 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 258 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg His Trp Thr Asp Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 259 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 259 ggatacagct ttaccagcta ctgg 24 <210> 260 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 260 Gly Tyr Ser Phe Thr Ser Tyr Trp 1 5 <210> 261 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 261 atctatcctg gtgactctga tacc 24 <210> 262 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 262 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 263 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 263 gcgagacact ggaccgacga ggatgctttt gatatc 36 <210> 264 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 264 Ala Arg His Trp Thr Asp Glu Asp Ala Phe Asp Ile 1 5 10 <210> 265 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 265 caggtccagc tggtgcagtc tgggactgag gtgaagaagc ctgggtcttc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcggc agttatccta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactcc 180 gcacagaagt tccagggcag agtcacgatt accacggacg aacccacgag cacagccttc 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccgtat 300 tacgatattt tgactgacta ctacggtatg gacgtctggg gtcaagggac cacggtcacc 360 gtctcctca 369 <210> 266 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 266 Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr 20 25 30 Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Ser Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Pro Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 267 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 267 ggaggcacct tcggcagtta tcct 24 <210> 268 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 268 Gly Gly Thr Phe Gly Ser Tyr Pro 1 5 <210> 269 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 269 atcatcccta tctttggtac agca 24 <210> 270 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 270 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 271 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 271 gcgagaccgt attacgatat tttgactgac tactacggta tggacgtc 48 <210> 272 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 272 Ala Arg Pro Tyr Tyr Asp Ile Leu Thr Asp Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 273 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 273 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacagaaggg 300 tacaactgga actatgacta ttggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 274 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 274 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Gly Tyr Asn Trp Asn Tyr Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 275 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 275 ggaggcacct tcagcagcta tgct 24 <210> 276 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 276 Gly Gly Thr Phe Ser Ser Tyr Ala 1 5 <210> 277 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 277 atcatcccta tctttggtac agca 24 <210> 278 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 278 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 279 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 279 gcgacagaag ggtacaactg gaactatgac tat 33 <210> 280 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 280 Ala Thr Glu Gly Tyr Asn Trp Asn Tyr Asp Tyr 1 5 10 <210> 281 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 281 caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc agctatgtta tcacctgggt gcgacaggtc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240 atggacctga gcagcctgag atctgaggac acggcctttt attattgtgc gagaaggagg 300 tctaactggg gatctcatgc ttttgatatc tggggccaag ggacaatggt caccgtctct 360 tca 363 <210> 282 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 282 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Val Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 85 90 95 Ala Arg Arg Arg Ser Asn Trp Gly Ser His Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 283 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 283 ggaggcacct tcagcagcta tgtt 24 <210> 284 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 284 Gly Gly Thr Phe Ser Ser Tyr Val 1 5 <210> 285 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 285 atcatcccta tctttggtac agca 24 <210> 286 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 286 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 287 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 287 gcgagaagga ggtctaactg gggatctcat gcttttgata tc 42 <210> 288 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 288 Ala Arg Arg Arg Ser Asn Trp Gly Ser His Ala Phe Asp Ile 1 5 10 <210> 289 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 289 gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggaat cacctttgat gattatgcca tgtactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agttgaggac acggccttgt attattgtgc aaaagataag 300 gggtattacg atattttgac tggagattac tactactact acggtatgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 290 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 290 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asp Asp Tyr 20 25 30 Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Lys Gly Tyr Tyr Asp Ile Leu Thr Gly Asp Tyr Tyr Tyr 100 105 110 Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 291 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 291 ggaatcacct ttgatgatta tgcc 24 <210> 292 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 292 Gly Ile Thr Phe Asp Asp Tyr Ala 1 5 <210> 293 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 293 attagttgga atagtggtag cata 24 <210> 294 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 294 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 295 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 295 gcaaaagata aggggtatta cgatattttg actggagatt actactacta ctacggtatg 60 gacgtc 66 <210> 296 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 296 Ala Lys Asp Lys Gly Tyr Tyr Asp Ile Leu Thr Gly Asp Tyr Tyr Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 297 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 297 gaggtgcagc tggtggagtc tgggggaagc ttggtacagc ctggggggtc cctcagactc 60 tcctgtgcag cctctggatt cacctttagc atctctgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtagta gtggtgttag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgatgac acggccgtat attactgtgc gaaagggagc 300 agctggtact acttcgacta ctggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 298 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 298 Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Ser 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 299 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 299 ggattcacct ttagcatctc tgcc 24 <210> 300 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 300 Gly Phe Thr Phe Ser Ile Ser Ala 1 5 <210> 301 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 301 attagtagta gtggtgttag caca 24 <210> 302 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 302 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 303 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 303 gcgaaaggga gcagctggta ctacttcgac tac 33 <210> 304 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 304 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr 1 5 10 <210> 305 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 305 gacatcgtga tgacccagtc tccaggcatt ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccagact cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggac 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacacta cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 306 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 306 Asp Ile Val Met Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Asp 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser His 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 307 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 307 cagagtgtta gcagcagcta c 21 <210> 308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 308 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 309 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 309 ggtgcatcc 9 <210> 310 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 310 Gly Ala Ser 1 <210> 311 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 311 cagcagtatg gtagctcaca ctacact 27 <210> 312 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 312 Gln Gln Tyr Gly Ser Ser His Tyr Thr 1 5 <210> 313 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 313 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagag cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactatt ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctatcaca gtgggaggac caactacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctggact ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agggggcagc 300 tcgtccctct actactacta tggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 314 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 314 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Ser Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr His Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asp Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Gly Ser Ser Ser Leu Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 315 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 315 ggtggctcca tcagtagtta ctat 24 <210> 316 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 316 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 317 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 317 atctatcaca gtgggaggac c 21 <210> 318 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 318 Ile Tyr His Ser Gly Arg Thr 1 5 <210> 319 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 319 gcgagagggg gcagctcgtc cctctactac tactatggta tggacgtc 48 <210> 320 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 320 Ala Arg Gly Gly Ser Ser Ser Leu Tyr Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 321 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 321 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 322 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 322 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 323 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 323 cagggcatta gaaatgat 18 <210> 324 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 324 Gln Gly Ile Arg Asn Asp 1 5 <210> 325 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 325 gctgcatcc 9 <210> 326 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 326 Ala Ala Ser 1 <210> 327 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 327 ctacagcata atagttaccc gtggacg 27 <210> 328 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 328 Leu Gln His Asn Ser Tyr Pro Trp Thr 1 5 <210> 329 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 329 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt cacgttcagc aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcatcg atatggtatg atggaagtaa taaaaactat 180 gcagactccg tgaagggtcg attcaccatc tccagagaca atcctaagaa cacgctgcat 240 ctgcaaatga gcagcctgag agccgaggac acggctatct attattgtgc gacagagata 300 gcagctcgtc cttttgagta ctggggccag ggaatcctgg tcaccgtctc ctca 354 <210> 330 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 330 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu His 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Ile 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 331 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 331 ggattcacgt tcagcaacta tggc 24 <210> 332 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 332 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 333 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 333 atatggtatg atggaagtaa taaa 24 <210> 334 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 334 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 335 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 335 gcgacagaga tagcagctcg tccttttgag tac 33 <210> 336 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 336 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 337 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 337 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 338 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 338 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 339 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 339 cagagcatta gcagctat 18 <210> 340 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 340 Gln Ser Ile Ser Ser Tyr 1 5 <210> 341 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 341 gctgcatcc 9 <210> 342 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 342 Ala Ala Ser 1 <210> 343 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 343 caacagagtt acagtacccc tctcact 27 <210> 344 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 344 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 345 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 345 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacttttaga agctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccgac ataaagcaag atggaagtga gaaatactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagatcccat 300 tacgattttt ggagtggttg ggactacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 346 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 346 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asp Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser His Tyr Asp Phe Trp Ser Gly Trp Asp Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 347 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 347 ggattcactt ttagaagcta ttgg 24 <210> 348 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 348 Gly Phe Thr Phe Arg Ser Tyr Trp 1 5 <210> 349 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 349 ataaagcaag atggaagtga gaaa 24 <210> 350 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 350 Ile Lys Gln Asp Gly Ser Glu Lys 1 5 <210> 351 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 351 gcgagatccc attacgattt ttggagtggt tgggactacg gtatggacgt c 51 <210> 352 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 352 Ala Arg Ser His Tyr Asp Phe Trp Ser Gly Trp Asp Tyr Gly Met Asp 1 5 10 15 Val <210> 353 <211> 322 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 353 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctcactt tcggcggagg 300 gaccaaggtg gagatcaaac ga 322 <210> 354 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 354 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro His 85 90 95 Phe Arg Arg Arg Asp Gln Gly Gly Asp Gln Thr 100 105 <210> 355 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 355 cagagcatta gcagctat 18 <210> 356 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 356 Gln Ser Ile Ser Ser Tyr 1 5 <210> 357 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 357 gctgcatcc 9 <210> 358 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 358 Ala Ala Ser 1 <210> 359 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 359 caacagagt 9 <210> 360 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 360 Gln Gln Ser 1 <210> 361 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 361 gaggtgcagc tggtggagtc tgggggaggc gtggtccagt ctgggaggtc cctgagactt 60 tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggactg ggtggcactt atatggcttg atggaagtca tgaaaactat 180 gcagactccg tgaagggccg attcaccata tccagagaca attccaagaa cacactattt 240 ctgcaaatga acaacctgag agccgaggac acggctgtgt actactgtgc gacagagata 300 gcagctcgtc cttttgagta ctggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 362 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 362 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 Ala Leu Ile Trp Leu Asp Gly Ser His Glu Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 363 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 363 ggattcacct tcagtaacta tggc 24 <210> 364 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 364 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 365 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 365 atatggcttg atggaagtca tgaa 24 <210> 366 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 366 Ile Trp Leu Asp Gly Ser His Glu 1 5 <210> 367 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 367 gcgacagaga tagcagctcg tccttttgag tac 33 <210> 368 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 368 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 369 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 369 gacatcctga tgacccagtc tccatcctcc ctgtctacat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccgtcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacattt cccctctcac tgtcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 370 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 370 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ser Pro Leu 85 90 95 Thr Val Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 371 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 371 cagagcatta gcacctat 18 <210> 372 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 372 Gln Ser Ile Ser Thr Tyr 1 5 <210> 373 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 373 gctgcatcc 9 <210> 374 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 374 Ala Ala Ser 1 <210> 375 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 375 caacagagtt acatttcccc tctcact 27 <210> 376 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 376 Gln Gln Ser Tyr Ile Ser Pro Leu Thr 1 5 <210> 377 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 377 gaggtgcagc tggtggagtc tgggggaggc ttggtacagt ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt taccttcagc acttatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtagta gcggtgttag cacacactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaagtga acagcctgag agccgaggac acggccgtat atttttgtgc taaagggagt 300 gcctggtact acttcgactt ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 378 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 378 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Val Ser Thr His Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Lys Gly Ser Ala Trp Tyr Tyr Phe Asp Phe Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 379 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 379 ggatttacct tcagcactta tgcc 24 <210> 380 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 380 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 381 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 381 attagtagta gcggtgttag caca 24 <210> 382 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 382 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 383 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 383 gctaaaggga gtgcctggta ctacttcgac ttc 33 <210> 384 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 384 Ala Lys Gly Ser Ala Trp Tyr Tyr Phe Asp Phe 1 5 10 <210> 385 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 385 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 actggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttcctgtcaa cagtatggtg gctcaccgat caccttcggc 300 caagggacac gactggagat taaacga 327 <210> 386 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 386 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Thr Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 387 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 387 cagagtgtta gcagcagcta c 21 <210> 388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 388 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 389 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 389 ggtgcatcc 9 <210> 390 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 390 Gly Ala Ser 1 <210> 391 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 391 caacagtatg gtggctcacc gatcacc 27 <210> 392 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 392 Gln Gln Tyr Gly Gly Ser Pro Ile Thr 1 5 <210> 393 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 393 gaggtgcagc tggtggagtc tgggggaggc gtggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct 120 ccagggaagg gtctggagtg ggtctctctt attagtgggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac accgccttgt attactgtgc aaaagataac 300 tatgatagta gtggttatta ctacgttaac tactactact acggtatgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 394 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 394 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Asn Tyr Asp Ser Ser Gly Tyr Tyr Tyr Val Asn Tyr Tyr 100 105 110 Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 395 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 395 ggattcacct ttgatgatta tgcc 24 <210> 396 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 396 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 397 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 397 attagtgggg atggtggtag caca 24 <210> 398 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 398 Ile Ser Gly Asp Gly Gly Ser Thr 1 5 <210> 399 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 399 gcaaaagata actatgatag tagtggttat tactacgtta actactacta ctacggtatg 60 gacgtc 66 <210> 400 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 400 Ala Lys Asp Asn Tyr Asp Ser Ser Gly Tyr Tyr Tyr Val Asn Tyr Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 401 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 401 gaaatcgtga tgacccagtc tccagcattc atgtcagcga ctccaggaga caaagtcaac 60 atctcctgca aagccagcca agacattgat gatgatatga actggtacca acagaaacca 120 ggagaagctg ctattttcat tattcaagaa gctactactc tcgttcctgg aatctcacct 180 cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catagaatct 240 gaggatgctg catattactt ctgtctacaa catgataatt tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 402 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 402 Glu Ile Val Met Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 1 5 10 15 Asp Lys Val Asn Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp 20 25 30 Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 35 40 45 Gln Glu Ala Thr Thr Leu Val Pro Gly Ile Ser Pro Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 65 70 75 80 Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln His Asp Asn Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 403 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 403 caagacattg atgatgat 18 <210> 404 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 404 Gln Asp Ile Asp Asp Asp 1 5 <210> 405 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 405 gaagctact 9 <210> 406 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 406 Glu Ala Thr 1 <210> 407 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 407 ctacaacatg ataatttccc gtacact 27 <210> 408 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 408 Leu Gln His Asp Asn Phe Pro Tyr Thr 1 5 <210> 409 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 409 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctgggtt caccttcagt aattatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atatggtatg atggaagtaa taaaaactat 180 acagagtccg tgaagggccg attcaccatc tccagagaca attccgaaaa cacactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt atttctgtgc gagcgagatc 300 gcagctcgtc cttttgagta ttggggccag ggaaccatgg tcaccgtctc ctca 354 <210> 410 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 410 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Thr Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 411 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 411 gggttcacct tcagtaatta tggc 24 <210> 412 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 412 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 413 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 413 atatggtatg atggaagtaa taaa 24 <210> 414 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 414 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 415 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 415 gcgagcgaga tcgcagctcg tccttttgag tat 33 <210> 416 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 416 Ala Ser Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 417 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 417 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggctagtca gagcattagc aactatttag attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccaatt tggaaactgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat tttactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag gctaacaatt tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 418 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 418 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Asn Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 419 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 419 cagagcatta gcaactat 18 <210> 420 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 420 Gln Ser Ile Ser Asn Tyr 1 5 <210> 421 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 421 gctgcatcc 9 <210> 422 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 422 Ala Ala Ser 1 <210> 423 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 423 caacaggcta acaatttccc gtacact 27 <210> 424 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 424 Gln Gln Ala Asn Asn Phe Pro Tyr Thr 1 5 <210> 425 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 425 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atatggtttg atggaagtaa taaaaactat 180 acagactccg tgaagggtcg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga gtagcctgag agccgaagac acggctgtgt attattgtgc gacagagata 300 gcagctcgtc cttttgagta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 426 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 426 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Phe Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 427 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 427 ggattcacct tcagtagcta tggc 24 <210> 428 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 428 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 429 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 429 atatggtttg atggaagtaa taaa 24 <210> 430 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 430 Ile Trp Phe Asp Gly Ser Asn Lys 1 5 <210> 431 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 431 gcgacagaga tagcagctcg tccttttgag tac 33 <210> 432 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 432 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 433 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 433 gacatcgtga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca 120 gggaaagccc ctaagctcct gatctatgtt gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaataatt accctcacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 434 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 434 Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Asn Tyr Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 435 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 435 cagggcatta gcagttat 18 <210> 436 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 436 Gln Gly Ile Ser Ser Tyr 1 5 <210> 437 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 437 gttgcatcc 9 <210> 438 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 438 Val Ala Ser 1 <210> 439 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 439 caacagctta ataattaccc tcacact 27 <210> 440 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 440 Gln Gln Leu Asn Asn Tyr Pro His Thr 1 5 <210> 441 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 441 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcacta atatggtatg atggaagtaa taaaaactat 180 acagactccg tgaagggtcg attcaccata tccagagaca attccaagaa cacactgtat 240 ctccaaatga gcagcctgag agccgaagac acggctgtat attattgtgc gacagaaata 300 gcagctcgtc cttttgaata ttggggccag ggaaccatgg tcaccgtctc ctca 354 <210> 442 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 442 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 443 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 443 ggattcacct tcagtaacta tggc 24 <210> 444 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 444 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 445 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 445 atatggtatg atggaagtaa taaa 24 <210> 446 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 446 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 447 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 447 gcgacagaaa tagcagctcg tccttttgaa tat 33 <210> 448 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 448 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 449 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 449 gacatcgtgc tgacccagtc tccagcattc atgtcagcga ctccaggaga caaagtcaac 60 atctcctgca aagccagcca agacattgat gatgatatga actggtacca acagaaacca 120 ggagaagctg ctattttcat tattcaagaa gctactactc tcgttcctgg aatctcacct 180 cgattcagtg gcagcgggta tggaacagat tttaccctca caattaataa catagaatct 240 gaggatgctg catattactt ctgtctacaa catgataatt tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 450 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 450 Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Met Ser Ala Thr Pro Gly 1 5 10 15 Asp Lys Val Asn Ile Ser Cys Lys Ala Ser Gln Asp Ile Asp Asp Asp 20 25 30 Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Ala Ile Phe Ile Ile 35 40 45 Gln Glu Ala Thr Thr Leu Val Pro Gly Ile Ser Pro Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 65 70 75 80 Glu Asp Ala Ala Tyr Tyr Phe Cys Leu Gln His Asp Asn Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 451 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 451 caagacattg atgatgat 18 <210> 452 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 452 Gln Asp Ile Asp Asp Asp 1 5 <210> 453 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 453 gaagctact 9 <210> 454 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 454 Glu Ala Thr 1 <210> 455 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 455 ctacaacatg ataatttccc gtacact 27 <210> 456 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 456 Leu Gln His Asp Asn Phe Pro Tyr Thr 1 5 <210> 457 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 457 gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgct gattatggaa tgaactgggt ccgccaagtt 120 ccagggaagg gactggagtg ggtctctggt attaattata agggtgatag tacaaattat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acaatcttag agccgaggac acggccttgt atcactgtgc gagagaaatt 300 tattgtatta atggtgtatg ttatacggac tactactacg gtatggacgt ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 458 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 458 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Tyr Lys Gly Asp Ser Thr Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 85 90 95 Ala Arg Glu Ile Tyr Cys Ile Asn Gly Val Cys Tyr Thr Asp Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 459 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 459 ggattcacct ttgctgatta tgga 24 <210> 460 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 460 Gly Phe Thr Phe Ala Asp Tyr Gly 1 5 <210> 461 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 461 attaattata agggtgatag taca 24 <210> 462 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 462 Ile Asn Tyr Lys Gly Asp Ser Thr 1 5 <210> 463 <211> 63 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 463 gcgagagaaa tttattgtat taatggtgta tgttatacgg actactacta cggtatggac 60 gtc 63 <210> 464 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 464 Ala Arg Glu Ile Tyr Cys Ile Asn Gly Val Cys Tyr Thr Asp Tyr Tyr 1 5 10 15 Tyr Gly Met Asp Val 20 <210> 465 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 465 gacatcctga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaaggca gagcattaac agctatttaa attggtatca acagaaacca 120 gggaaagccc ctaaactcct catctatgtt gcatccagtt tgcaaagcgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcaacag tctgcagcct 240 gaggatttcg caatttattt ctgtcaacag agttacagta ccccgatcac cttcggccaa 300 gggaccaaac tggagatcaa acga 324 <210> 466 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 466 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Gln Ser Ile Asn Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 467 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 467 cagagcatta acagctat 18 <210> 468 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 468 Gln Ser Ile Asn Ser Tyr 1 5 <210> 469 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 469 gttgcatcc 9 <210> 470 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 470 Val Ala Ser 1 <210> 471 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 471 caacagagtt acagtacccc gatcacc 27 <210> 472 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 472 Gln Gln Ser Tyr Ser Thr Pro Ile Thr 1 5 <210> 473 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 473 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcacta atatggtttg atggaagtaa taaaaactat 180 acagactccg tgaagggtcg attcaccata tccagagaca attccaagaa cacactgtat 240 ctccaaatga gcagcctgag agccgaagac acggctgtat attattgtgc gacagaaata 300 gcagctcgtc cttttgaata ttggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 474 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 474 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Phe Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 475 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 475 ggattcacct tcagtaacta tggc 24 <210> 476 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 476 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 477 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 477 atatggtttg atggaagtaa taaa 24 <210> 478 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 478 Ile Trp Phe Asp Gly Ser Asn Lys 1 5 <210> 479 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 479 gcgacagaaa tagcagctcg tccttttgaa tat 33 <210> 480 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 480 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 481 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 481 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca agtctagtca gagcctcctt catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaaatccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 482 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 482 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 483 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 483 cagagcctcc ttcatagtaa tggatacaac tat 33 <210> 484 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 484 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 485 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 485 ttgggttct 9 <210> 486 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 486 Leu Gly Ser 1 <210> 487 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 487 atgcaagctc tacaaaatcc gtacact 27 <210> 488 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 488 Met Gln Ala Leu Gln Asn Pro Tyr Thr 1 5 <210> 489 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 489 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atatggtttg atggaagtaa taaaaactat 180 acagactccg tgaagggtcg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga gtagcctgag agccgaagac acggctgtgt attattgtgc gacagagata 300 gcagctcgtc cttttgagta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 490 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 490 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Phe Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 491 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 491 ggattcacct tcagtagcta tggc 24 <210> 492 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 492 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 493 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 493 atatggtttg atggaagtaa taaa 24 <210> 494 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 494 Ile Trp Phe Asp Gly Ser Asn Lys 1 5 <210> 495 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 495 gcgacagaga tagcagctcg tccttttgag tac 33 <210> 496 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 496 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 497 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 497 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 498 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 498 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 499 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 499 cagagcatta gcagctat 18 <210> 500 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 500 Gln Ser Ile Ser Ser Tyr 1 5 <210> 501 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 501 gctgcatcc 9 <210> 502 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 502 Ala Ala Ser 1 <210> 503 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 503 caacagagtt acagtacccc gtacact 27 <210> 504 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 504 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 505 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 505 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctgggtt caccttcagt aattatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atatggtatg atggaagtaa taaaaactat 180 acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt atttctgtgc gagcgagatc 300 gcagctcgtc cttttgagta ctggggccag ggaaccatgg tcaccgtctc ctca 354 <210> 506 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 506 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 507 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 507 gggttcacct tcagtaatta tggc 24 <210> 508 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 508 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 509 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 509 atatggtatg atggaagtaa taaa 24 <210> 510 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 510 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 511 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 511 gcgagcgaga tcgcagctcg tccttttgag tac 33 <210> 512 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 512 Ala Ser Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 513 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 513 gacatcgtga tgacccagtc tccttcctcc ctgtctgcat ctttaggaga cagagtcacc 60 ttcacttgcc gggcaagtca gagcattcgc agccatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatact acatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 514 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 514 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 515 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 515 cagagcattc gcagccat 18 <210> 516 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 516 Gln Ser Ile Arg Ser His 1 5 <210> 517 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 517 actacatcc 9 <210> 518 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 518 Thr Thr Ser 1 <210> 519 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 519 caacagagtt acagtacccc gtacact 27 <210> 520 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 520 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 521 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 521 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggac cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaagt attagtagta gtggtgttag cacatactac 180 gcagactccg tgaagggccg gttcaccatt tccagagaca attccaagaa cacggtgtat 240 ctgcacatga acagcctgag agccgaggac acggccctat attactgtgc gcaagggagt 300 agctggtact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 522 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 522 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu His Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Gln Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 523 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 523 ggattcacct ttagcaccta tgcc 24 <210> 524 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 524 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 525 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 525 attagtagta gtggtgttag caca 24 <210> 526 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 526 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 527 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 527 gcgcaaggga gtagctggta ctactttgac tac 33 <210> 528 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 528 Ala Gln Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr 1 5 10 <210> 529 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 529 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacag cataatagtt accctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 530 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 530 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 531 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 531 cagggcatta gaaatgat 18 <210> 532 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 532 Gln Gly Ile Arg Asn Asp 1 5 <210> 533 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 533 gctgcatcc 9 <210> 534 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 534 Ala Ala Ser 1 <210> 535 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 535 ctacagcata atagttaccc tccgacg 27 <210> 536 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 536 Leu Gln His Asn Ser Tyr Pro Pro Thr 1 5 <210> 537 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 537 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggcg 120 ccaggcaagg ggctggagtg ggtggcactt atatggtatg atggaagtaa taaaaactat 180 acagactccg tgaagggtcg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga gcagcctgag agccgaggac acggctgtgt attattgtgc gacagagata 300 gcagctcgtc cttttgagta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 538 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 538 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 539 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 539 ggattcacct tcagtagcta tggc 24 <210> 540 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 540 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 541 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 541 atatggtatg atggaagtaa taaa 24 <210> 542 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 542 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 543 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 543 gcgacagaga tagcagctcg tccttttgag tac 33 <210> 544 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 544 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 545 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 545 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagtattaag atctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaggtcct gatctatggt gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tcttcaacct 240 gaagattttg caacttactt ctgtcaacag agttacagta ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 546 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 546 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Lys Ile Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 547 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 547 cagagtatta agatctat 18 <210> 548 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 548 Gln Ser Ile Lys Ile Tyr 1 5 <210> 549 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 549 ggtgcatcc 9 <210> 550 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 550 Gly Ala Ser 1 <210> 551 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 551 caacagagtt acagtacccc attcact 27 <210> 552 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 552 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 553 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 553 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt aattatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atatggtatg atggaagtaa taaaaactat 180 acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt atttctgtgc gagcgagatc 300 gcagctcgtc cttttgagta ctggggccag ggaaccatgg tcaccgtctc ctca 354 <210> 554 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 554 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ser Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 555 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 555 ggattcacct tcagtaatta tggc 24 <210> 556 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 556 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 557 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 557 atatggtatg atggaagtaa taaa 24 <210> 558 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 558 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 559 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 559 gcgagcgaga tcgcagctcg tccttttgag tac 33 <210> 560 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 560 Ala Ser Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 561 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 561 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 562 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 562 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 563 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 563 caggacatta gcaactat 18 <210> 564 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 564 Gln Asp Ile Ser Asn Tyr 1 5 <210> 565 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 565 gatgcatcc 9 <210> 566 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 566 Asp Ala Ser 1 <210> 567 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 567 caacagtatg ataatctccc gctcact 27 <210> 568 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 568 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 569 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 569 gaggtgcagc tggtggagtc tgggggaggc gaggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcacta atatggtatg atggaagtaa taaaaactat 180 acagactccg tgaagggtcg attcaccata tccagagaca attccaagaa cactctgtat 240 ctccaaatga gcagcctgag agccgaagac acggctgtat attattgtgc gacagaaata 300 gcagctcgtc cttttgaata ttggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 570 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 570 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 571 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 571 ggattcacct tcagtaacta tggc 24 <210> 572 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 572 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 573 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 573 atatggtatg atggaagtaa taaa 24 <210> 574 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 574 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 575 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 575 gcgacagaaa tagcagctcg tccttttgaa tat 33 <210> 576 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 576 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 577 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 577 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacag cataatagtt acccgtacac ttttggccag 300 gggaccaagg tggaaatcaa acga 324 <210> 578 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 578 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 579 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 579 cagggcatta gaaatgat 18 <210> 580 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 580 Gln Gly Ile Arg Asn Asp 1 5 <210> 581 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 581 gctgcatcc 9 <210> 582 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 582 Ala Ala Ser 1 <210> 583 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 583 ctacagcata atagttaccc gtacact 27 <210> 584 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 584 Leu Gln His Asn Ser Tyr Pro Tyr Thr 1 5 <210> 585 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 585 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttaga agctatttga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acaccctgag agccgaggac acggctgtgt attactgtgc gagagcccat 300 tacgattttt ggagtgcttg ggactacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 586 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 586 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 20 25 30 Leu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala His Tyr Asp Phe Trp Ser Ala Trp Asp Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 587 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 587 ggattcacct ttagaagcta tttg 24 <210> 588 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 588 Gly Phe Thr Phe Arg Ser Tyr Leu 1 5 <210> 589 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 589 ataaagcaag atggaagtga gaaa 24 <210> 590 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 590 Ile Lys Gln Asp Gly Ser Glu Lys 1 5 <210> 591 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 591 gcgagagccc attacgattt ttggagtgct tgggactacg gtatggacgt c 51 <210> 592 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 592 Ala Arg Ala His Tyr Asp Phe Trp Ser Ala Trp Asp Tyr Gly Met Asp 1 5 10 15 Val <210> 593 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 593 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggccga 300 gggaccaagg tggagatcaa acga 324 <210> 594 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 594 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 595 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 595 cagagcatta gcagctat 18 <210> 596 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 596 Gln Ser Ile Ser Ser Tyr 1 5 <210> 597 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 597 gctgcatcc 9 <210> 598 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 598 Ala Ala Ser 1 <210> 599 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 599 caacagagtt acagtacccc gctcact 27 <210> 600 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 600 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 601 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 601 gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgct gattatggaa tgaactgggt ccgccaagtt 120 ccagggaagg gactggagtg ggtctctggt attaattata agggtgatag tacaaattat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acaatcttag agccgaggac acggccttgt atcactgtgc gagagaaatt 300 tattgtatta atggtgtatg ttatacggac tactactacg gtatggacgt ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 602 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 602 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Tyr Lys Gly Asp Ser Thr Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 85 90 95 Ala Arg Glu Ile Tyr Cys Ile Asn Gly Val Cys Tyr Thr Asp Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 603 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 603 ggattcacct ttgctgatta tgga 24 <210> 604 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 604 Gly Phe Thr Phe Ala Asp Tyr Gly 1 5 <210> 605 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 605 attaattata agggtgatag taca 24 <210> 606 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 606 Ile Asn Tyr Lys Gly Asp Ser Thr 1 5 <210> 607 <211> 63 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 607 gcgagagaaa tttattgtat taatggtgta tgttatacgg actactacta cggtatggac 60 gtc 63 <210> 608 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 608 Ala Arg Glu Ile Tyr Cys Ile Asn Gly Val Cys Tyr Thr Asp Tyr Tyr 1 5 10 15 Tyr Gly Met Asp Val 20 <210> 609 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 609 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tccccatatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 610 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 610 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 611 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 611 caggacatta gcaactat 18 <210> 612 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 612 Gln Asp Ile Ser Asn Tyr 1 5 <210> 613 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 613 gatgcatcc 9 <210> 614 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 614 Asp Ala Ser 1 <210> 615 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 615 caacagtatg ataatctccc catattcact 30 <210> 616 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 616 Gln Gln Tyr Asp Asn Leu Pro Ile Phe Thr 1 5 10 <210> 617 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 617 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt ggtttctact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcagtcata gtggaaacac cgactacatc 180 ccgtccctca agagtcgagt caccatatca ttagacacgt ccaagaacca gttctccctg 240 aagctgaact ctgtgaccgc cgcggacacg gctttttatt actgtgcgag aggtcctttt 300 tacgatattt tgactggtta tccctttgac tactggggcc agggaaccac ggtcaccgtc 360 tcctca 366 <210> 618 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 618 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Ser His Ser Gly Asn Thr Asp Tyr Ile Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Phe Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 619 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 619 ggtgggtcct tcagtggttt ctac 24 <210> 620 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 620 Gly Gly Ser Phe Ser Gly Phe Tyr 1 5 <210> 621 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 621 atcagtcata gtggaaacac c 21 <210> 622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 622 Ile Ser His Ser Gly Asn Thr 1 5 <210> 623 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 623 gcgagaggtc ctttttacga tattttgact ggttatccct ttgactac 48 <210> 624 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 624 Ala Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr 1 5 10 15 <210> 625 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 625 gacatcgtga tgacccagtc tccagccatt ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctctt catctatggt gcatccacca gggccactgg tatcccagcc 180 agattcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 626 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 626 Asp Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Phe Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 627 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 627 cagagtgtta gcagcaac 18 <210> 628 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 628 Gln Ser Val Ser Ser Asn 1 5 <210> 629 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 629 ggtgcatcc 9 <210> 630 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 630 Gly Ala Ser 1 <210> 631 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 631 cagcagtata ataactggcc tctcact 27 <210> 632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 632 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 633 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 633 caggtgcagc tggtggagtc tgggggagac ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttact agctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaat ataaaacaag atggaactga gaactactat 180 gtggactctg tgaagggccg attcaccatt tccagagaca atgccaagaa ctcactgtat 240 ctgcaaatga gcagcctgag agccgaggac acggctgtgt attactgtgc gagagatcac 300 cccgtgggag ctcctttctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 634 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 634 Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Thr Glu Asn Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 635 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 635 ggattcacct ttactagcta ttgg 24 <210> 636 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 636 Gly Phe Thr Phe Thr Ser Tyr Trp 1 5 <210> 637 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 637 ataaaacaag atggaactga gaac 24 <210> 638 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 638 Ile Lys Gln Asp Gly Thr Glu Asn 1 5 <210> 639 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 639 gcgagagatc accccgtggg agctcctttc tttgactac 39 <210> 640 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 640 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 641 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 641 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc tactatttaa attggtatca acagaaacca 120 gggaaagccc ctaagctcct gatctatagt gaatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacacta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 642 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 642 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Glu Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 643 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 643 cagagcatta gctactat 18 <210> 644 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 644 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 645 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 645 agtgaatcc 9 <210> 646 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 646 Ser Glu Ser 1 <210> 647 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 647 caacagagtt acactacccc gtacact 27 <210> 648 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 648 Gln Gln Ser Tyr Thr Thr Pro Tyr Thr 1 5 <210> 649 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 649 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcaat ggtttctact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcagtcata gtggaaacac cgactacatc 180 ccgtccctca agagtcgagt caccatatca atagacacgt ccaagagcca gttcttcctg 240 aagctgaact ctgtgaccgc cgcggacacg gctttttatt actgtgcgag gggtcccttt 300 tacgatattt tgactggcta cccctttgac tactggggcc agggaaccac ggtcaccgtc 360 tcctca 366 <210> 650 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 650 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Gly Phe 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Ser His Ser Gly Asn Thr Asp Tyr Ile Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe Phe Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Phe Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 651 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 651 ggtgggtcct tcaatggttt ctac 24 <210> 652 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 652 Gly Gly Ser Phe Asn Gly Phe Tyr 1 5 <210> 653 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 653 atcagtcata gtggaaacac c 21 <210> 654 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 654 Ile Ser His Ser Gly Asn Thr 1 5 <210> 655 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 655 gcgaggggtc ccttttacga tattttgact ggctacccct ttgactac 48 <210> 656 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 656 Ala Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr 1 5 10 15 <210> 657 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 657 gacatcgtga tgacccagtc tccagccatt ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtattgac agccacttag cctggtacct gcagaaacct 120 ggccaggctc ccaggctctt catctatggt gcatcctcca gggccactgg tatcccagtc 180 agattcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tataatagtt ggcctctcac tttcggcgga 300 gggaccaagc tggagatcaa acga 324 <210> 658 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 658 Asp Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asp Ser His 20 25 30 Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ala Pro Arg Leu Phe Ile 35 40 45 Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 659 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 659 cagagtattg acagccac 18 <210> 660 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 660 Gln Ser Ile Asp Ser His 1 5 <210> 661 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 661 ggtgcatcc 9 <210> 662 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 662 Gly Ala Ser 1 <210> 663 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 663 cagcagtata atagttggcc tctcact 27 <210> 664 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 664 Gln Gln Tyr Asn Ser Trp Pro Leu Thr 1 5 <210> 665 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 665 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt catgtttagt ggttattgga tgaactgggt ccgtcaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaggtga gaaatactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac atggctgtgt attactgtgc gagagatcac 300 ccagtgggag ctcctttctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 666 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 666 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Ser Gly Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 667 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 667 ggattcatgt ttagtggtta ttgg 24 <210> 668 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 668 Gly Phe Met Phe Ser Gly Tyr Trp 1 5 <210> 669 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 669 ataaagcaag atggaggtga gaaa 24 <210> 670 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 670 Ile Lys Gln Asp Gly Gly Glu Lys 1 5 <210> 671 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 671 gcgagagatc acccagtggg agctcctttc tttgactac 39 <210> 672 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 672 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 673 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 673 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc tactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctgtgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcactggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 674 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 674 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Cys Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 675 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 675 cagagcatta gctactat 18 <210> 676 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 676 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 677 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 677 gctgcatcc 9 <210> 678 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 678 Ala Ala Ser 1 <210> 679 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 679 caacagagtt acagtacccc gtacact 27 <210> 680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 680 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 681 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 681 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt ggtttctact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcagtcata gtggaaacac cgactacatc 180 ccgtccctca agagtcgagt caccatatca ttagacacgt ccaagaacca gttctccctg 240 aagctgaact ctgtgaccgc cgcggacacg gctttttatt actgtgcgag aggtcctttt 300 tacgatattt tgactggtta cccctttgac tactggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 682 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 682 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Ser His Ser Gly Asn Thr Asp Tyr Ile Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Phe Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 683 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 683 ggtgggtcct tcagtggttt ctac 24 <210> 684 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 684 Gly Gly Ser Phe Ser Gly Phe Tyr 1 5 <210> 685 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 685 atcagtcata gtggaaacac c 21 <210> 686 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 686 Ile Ser His Ser Gly Asn Thr 1 5 <210> 687 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 687 gcgagaggtc ctttttacga tattttgact ggttacccct ttgactac 48 <210> 688 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 688 Ala Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr 1 5 10 15 <210> 689 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 689 gacatcgtga tgacccagtc tccagccatt ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctctt catctatggt gcatccacca gggccactgg tatcccagcc 180 agattcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tatgatacct ggcctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 690 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 690 Asp Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Phe Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Thr Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 691 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 691 cagagtgtta gcagcaac 18 <210> 692 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 692 Gln Ser Val Ser Ser Asn 1 5 <210> 693 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 693 ggtgcatcc 9 <210> 694 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 694 Gly Ala Ser 1 <210> 695 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 695 cagcagtatg atacctggcc tctcact 27 <210> 696 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 696 Gln Gln Tyr Asp Thr Trp Pro Leu Thr 1 5 <210> 697 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 697 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt catctttagt agctattgga tgaactgggt ccgccagact 120 ccagggaagg ggctggagtg ggtggccaat ataaaacaag atggaactga gaaatattat 180 gtggactctg tgaagggccg attcaccatc tccagagaca atgccaagaa atcactatat 240 ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagatcac 300 ccagtgggag ctcctttctt tgactactgg ggccagggaa ccatggtcac cgtctcctca 360 <210> 698 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 698 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Thr Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 699 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 699 ggattcatct ttagtagcta ttgg 24 <210> 700 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 700 Gly Phe Ile Phe Ser Ser Tyr Trp 1 5 <210> 701 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 701 ataaaacaag atggaactga gaaa 24 <210> 702 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 702 Ile Lys Gln Asp Gly Thr Glu Lys 1 5 <210> 703 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 703 gcgagagatc acccagtggg agctcctttc tttgactac 39 <210> 704 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 704 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 705 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 705 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt tactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct aatctatagt acatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 706 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 706 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ser Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 707 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 707 cagagcatta gttactat 18 <210> 708 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 708 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 709 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 709 agtacatcc 9 <210> 710 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 710 Ser Thr Ser 1 <210> 711 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 711 caacagagtt acagtacccc gtacact 27 <210> 712 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 712 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 713 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 713 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt catgtttagt ggttattgga tgaactgggt ccgtcaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaggtga gaaatactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac atggctgtgt attactgtgc gagagatcac 300 ccagtgggag ctcctttctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 714 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 714 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Ser Gly Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 715 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 715 ggattcatgt ttagtggtta ttgg 24 <210> 716 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 716 Gly Phe Met Phe Ser Gly Tyr Trp 1 5 <210> 717 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 717 ataaagcaag atggaggtga gaaa 24 <210> 718 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 718 Ile Lys Gln Asp Gly Gly Glu Lys 1 5 <210> 719 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 719 gcgagagatc acccagtggg agctcctttc tttgactac 39 <210> 720 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 720 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 721 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 721 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc tactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctgtgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcactggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 722 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 722 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Cys Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 723 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 723 cagagcatta gctactat 18 <210> 724 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 724 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 725 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 725 gctgcatcc 9 <210> 726 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 726 Ala Ala Ser 1 <210> 727 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 727 caacagagtt acagtacccc gtacact 27 <210> 728 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 728 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 729 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 729 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt catctttagt agctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaat ataaaacaag atggaactga gaaatattat 180 gtggactctg tgaagggccg attcaccatc tccagagaca atgccaagaa atcactatat 240 ctgcaaatga gcagcctgag agccgaggac acggctgtgt attactgtgc gagagatcac 300 ccagtgggag ctcctttctt tgactactgg ggccagggaa ccatggtcac cgtctcctca 360 <210> 730 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 730 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Thr Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 731 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 731 ggattcatct ttagtagcta ttgg 24 <210> 732 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 732 Gly Phe Ile Phe Ser Ser Tyr Trp 1 5 <210> 733 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 733 ataaaacaag atggaactga gaaa 24 <210> 734 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 734 Ile Lys Gln Asp Gly Thr Glu Lys 1 5 <210> 735 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 735 gcgagagatc acccagtggg agctcctttc tttgactac 39 <210> 736 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 736 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 737 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 737 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt tactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct aatctatagt acatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca gcatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 738 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 738 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ser Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 739 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 739 cagagcatta gttactat 18 <210> 740 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 740 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 741 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 741 agtacatcc 9 <210> 742 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 742 Ser Thr Ser 1 <210> 743 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 743 caacagagtt acagtacccc gtacact 27 <210> 744 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 744 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 745 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 745 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctgggggatc cctgaggctc 60 tcctgtgcag cctctggatt cacctttagt ggctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaat ataaaacacg atggaagtga gaaatactct 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcac 300 ccagtgggag ctcctttctt tgactactgg ggtcagggaa tcctggtcac cgtctcctca 360 <210> 746 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 746 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys His Asp Gly Ser Glu Lys Tyr Ser Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Ile Leu Val Thr Val Ser Ser 115 120 <210> 747 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 747 ggattcacct ttagtggcta ttgg 24 <210> 748 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 748 Gly Phe Thr Phe Ser Gly Tyr Trp 1 5 <210> 749 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 749 ataaaacacg atggaagtga gaaa 24 <210> 750 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 750 Ile Lys His Asp Gly Ser Glu Lys 1 5 <210> 751 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 751 gcgagagatc acccagtggg agctcctttc tttgactac 39 <210> 752 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 752 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 753 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 753 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt tactatttaa actggtatca gcagaaacca 120 gggaaagccc caaagctcct gatctatagt tcttccagtt tgcgaggtgg aatcccatca 180 aggttcagtg gcagtgattc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 754 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 754 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Ser Leu Arg Gly Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Asp Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 755 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 755 cagagcatta gttactat 18 <210> 756 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 756 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 757 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 757 agttcttcc 9 <210> 758 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 758 Ser Ser Ser 1 <210> 759 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 759 caacagagtt acagtacccc gtacact 27 <210> 760 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 760 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 761 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 761 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccgacagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaacac caagtacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aacctgacgt ctgtgaccac tgcggacacg gccgtgtatt actgtgcgag agatatagtg 300 gctgcgatta ggcctcactg gtacttcgat ctctggggcc gtggcaccac ggtcaccgtc 360 tcctca 366 <210> 762 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 762 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Thr Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ile Val Ala Ala Ile Arg Pro His Trp Tyr Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 763 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 763 ggtggctcca tcagtaatta ctac 24 <210> 764 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 764 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 765 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 765 atctattaca gtgggaacac c 21 <210> 766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 766 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 767 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 767 gcgagagata tagtggctgc gattaggcct cactggtact tcgatctc 48 <210> 768 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 768 Ala Arg Asp Ile Val Ala Ala Ile Arg Pro His Trp Tyr Phe Asp Leu 1 5 10 15 <210> 769 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 769 gacatccaga tgacccagtc tccatcctcc ctgtctgcgt ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattaac acctatttaa attggtatca gcagaatcca 120 gggaaagccc ctaaggtcct gatctatgct acatccattt tgctaagtgg ggtcccatcc 180 agattcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatttta caacttactt ctgtcaacag agttacagta tccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 770 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 770 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Asn Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Ala Thr Ser Ile Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Thr Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 771 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 771 cagaccatta acacctat 18 <210> 772 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 772 Gln Thr Ile Asn Thr Tyr 1 5 <210> 773 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 773 gctacatcc 9 <210> 774 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 774 Ala Thr Ser 1 <210> 775 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 775 caacagagtt acagtatccc tcccact 27 <210> 776 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 776 Gln Gln Ser Tyr Ser Ile Pro Pro Thr 1 5 <210> 777 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 777 gaggtgcagc tggtggagtc tgggggagac ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttggt gattatgcca tgcactgggt ccgacaacct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atggtggtag cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag acctgaggac acggccttgt attactgtgc aaaagatggg 300 ggtatagcag cagatgccga ctattactac ggtatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 778 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 778 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Gly Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Gly Ile Ala Ala Asp Ala Asp Tyr Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 779 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 779 ggattcacct ttggtgatta tgcc 24 <210> 780 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 780 Gly Phe Thr Phe Gly Asp Tyr Ala 1 5 <210> 781 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 781 attagttgga atggtggtag cata 24 <210> 782 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 782 Ile Ser Trp Asn Gly Gly Ser Ile 1 5 <210> 783 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 783 gcaaaagatg ggggtatagc agcagatgcc gactattact acggtatgga cgtc 54 <210> 784 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 784 Ala Lys Asp Gly Gly Ile Ala Ala Asp Ala Asp Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 785 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 785 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattacc aattttttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccgtct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag ccttcagcct 240 gaagatgttg cgacttatta ctgtcaaacc tataacagtg ccccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 786 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 786 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Asn Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Thr Tyr Asn Ser Ala Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 787 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 787 cagggcatta ccaatttt 18 <210> 788 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 788 Gln Gly Ile Thr Asn Phe 1 5 <210> 789 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 789 gctgcatcc 9 <210> 790 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 790 Ala Ala Ser 1 <210> 791 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 791 caaacctata acagtgcccc gctcact 27 <210> 792 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 792 Gln Thr Tyr Asn Ser Ala Pro Leu Thr 1 5 <210> 793 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 793 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc aactatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtct cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaacctcggt 300 ataactggaa ctaccccctt tgactactgg ggccagggaa ccacggtcac cgtctcctca 360 <210> 794 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 794 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asn Leu Gly Ile Thr Gly Thr Thr Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 795 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 795 ggattcacct ttagcaacta tgcc 24 <210> 796 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 796 Gly Phe Thr Phe Ser Asn Tyr Ala 1 5 <210> 797 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 797 attagtggta gtggtggtct caca 24 <210> 798 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 798 Ile Ser Gly Ser Gly Gly Leu Thr 1 5 <210> 799 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 799 gcgaacctcg gtataactgg aactaccccc tttgactac 39 <210> 800 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 800 Ala Asn Leu Gly Ile Thr Gly Thr Thr Pro Phe Asp Tyr 1 5 10 <210> 801 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 801 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtgaatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 802 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 802 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 803 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 803 cagagcatta gcaactat 18 <210> 804 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 804 Gln Ser Ile Ser Asn Tyr 1 5 <210> 805 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 805 gctgcatcc 9 <210> 806 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 806 Ala Ala Ser 1 <210> 807 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 807 caacagagtt acagtacccc tcccact 27 <210> 808 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 808 Gln Gln Ser Tyr Ser Thr Pro Pro Thr 1 5 <210> 809 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 809 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt catctttagt agctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaat ataaaacaag atggaactga gaaatattat 180 gtggactctg tgaagggccg attcaccatc tccagagaca atgccaagaa atcactatat 240 ctgcaaatga gcagcctgag agccgaggac acggctgtgt attactgtgc gagagatcac 300 ccagtgggag ctcctttctt tgactactgg ggccagggaa ccatggtcac cgtctcctca 360 <210> 810 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 810 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Thr Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 811 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 811 ggattcatct ttagtagcta ttgg 24 <210> 812 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 812 Gly Phe Ile Phe Ser Ser Tyr Trp 1 5 <210> 813 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 813 ataaaacaag atggaactga gaaa 24 <210> 814 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 814 Ile Lys Gln Asp Gly Thr Glu Lys 1 5 <210> 815 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 815 gcgagagatc acccagtggg agctcctttc tttgactac 39 <210> 816 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 816 Ala Arg Asp His Pro Val Gly Ala Pro Phe Phe Asp Tyr 1 5 10 <210> 817 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 817 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt tactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct aatctatagt acatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 818 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 818 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ser Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 819 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 819 cagagcatta gttactat 18 <210> 820 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 820 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 821 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 821 agtacatcc 9 <210> 822 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 822 Ser Thr Ser 1 <210> 823 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 823 caacagagtt acagtacccc gtacact 27 <210> 824 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 824 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 825 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 825 caggtgcagc tggtggagtc tggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt ggtttctact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcagtcata gtggaaacac cgactacatc 180 ccgtccctca agagtcgagt caccatatca ttagacacgt ccaagaacca gttctccctg 240 aagctgaact ctgtgaccgc cgcggacacg gctttttatt actgtgcgag aggtcctttt 300 tacgatattt tgactggtta cccctttgac tactggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 826 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 826 Gln Val Gln Leu Val Glu Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Phe 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Ser His Ser Gly Asn Thr Asp Tyr Ile Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Phe Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 827 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 827 ggtgggtcct tcagtggttt ctac 24 <210> 828 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 828 Gly Gly Ser Phe Ser Gly Phe Tyr 1 5 <210> 829 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 829 atcagtcata gtggaaacac c 21 <210> 830 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 830 Ile Ser His Ser Gly Asn Thr 1 5 <210> 831 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 831 gcgagaggtc ctttttacga tattttgact ggttacccct ttgactac 48 <210> 832 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 832 Ala Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Pro Phe Asp Tyr 1 5 10 15 <210> 833 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 833 gacatcgtga tgacccagtc tccagccatt ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctctt catctatggt gcatccacca gggccactgg tatcccagcc 180 agattcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 834 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 834 Asp Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Phe Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 835 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 835 cagagtgtta gcagcaac 18 <210> 836 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 836 Gln Ser Val Ser Ser Asn 1 5 <210> 837 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 837 ggtgcatcc 9 <210> 838 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 838 Gly Ala Ser 1 <210> 839 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 839 cagcagtata ataactggcc tctcact 27 <210> 840 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 840 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 841 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 841 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactatt ggagctggat ccgacagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaacac caagtacaac 180 ccctccctca agagtcgagt catcatatca gtagacacgt ccaagaacca gttctccctg 240 aacctgacgt ctgtgaccac tgcggacacg gccgtgtatt actgtgcgag agatatagtg 300 gctgcgatta ggcctcactg gtacttcgat ctctggggcc gtggcaccac ggtcaccgtc 360 tcctca 366 <210> 842 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 842 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Thr Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ile Val Ala Ala Ile Arg Pro His Trp Tyr Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 843 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 843 ggtggctcca tcagtaatta ctat 24 <210> 844 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 844 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 845 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 845 atctattaca gtgggaacac c 21 <210> 846 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 846 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 847 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 847 gcgagagata tagtggctgc gattaggcct cactggtact tcgatctc 48 <210> 848 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 848 Ala Arg Asp Ile Val Ala Ala Ile Arg Pro His Trp Tyr Phe Asp Leu 1 5 10 15 <210> 849 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 849 gacatcctga tgacccagtc tccatcctcc ctgtctgcgt ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattaac aactatttaa attggtatca gcaatatcca 120 ggaaaagccc ctaaagtcct gatctatgct gcatccattt tgctaagtgg ggtcccatcc 180 agattcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ctgtcaacag agttacagta tccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 850 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 850 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Ala Ala Ser Ile Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 851 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 851 cagaccatta acaactat 18 <210> 852 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 852 Gln Thr Ile Asn Asn Tyr 1 5 <210> 853 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 853 gctgcatcc 9 <210> 854 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 854 Ala Ala Ser 1 <210> 855 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 855 caacagagtt acagtatccc tcccact 27 <210> 856 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 856 Gln Gln Ser Tyr Ser Ile Pro Pro Thr 1 5 <210> 857 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 857 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccgacagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaacac caagtacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aacctgacgt ctgtgaccac tgcggacacg gccgtgtatt actgtgcgag agatatagtg 300 gctgcgatta ggcctcactg gtacttcgat ctctggggcc gtggcaccac ggtcaccgtc 360 tcctca 366 <210> 858 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 858 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Thr Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ile Val Ala Ala Ile Arg Pro His Trp Tyr Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 859 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 859 ggtggctcca tcagtaatta ctac 24 <210> 860 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 860 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 861 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 861 atctattaca gtgggaacac c 21 <210> 862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 862 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 863 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 863 gcgagagata tagtggctgc gattaggcct cactggtact tcgatctc 48 <210> 864 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 864 Ala Arg Asp Ile Val Ala Ala Ile Arg Pro His Trp Tyr Phe Asp Leu 1 5 10 15 <210> 865 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 865 gacatcctga tgacccagtc tccatcctcc ctgtctgcgt ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattaac acctatttaa attggtatca gcagaatcca 120 gggaaagccc ctaaggtcct gatctatggt acatccattt tgctaagtgg ggtcccatcc 180 agattcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatttta caagttactt ctgtcaacag agttacagta tccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 866 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 866 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Asn Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Gly Thr Ser Ile Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Thr Ser Tyr Phe Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 867 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 867 cagaccatta acacctat 18 <210> 868 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 868 Gln Thr Ile Asn Thr Tyr 1 5 <210> 869 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 869 ggtacatcc 9 <210> 870 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 870 Gly Thr Ser 1 <210> 871 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 871 caacagagtt acagtatccc tcccact 27 <210> 872 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 872 Gln Gln Ser Tyr Ser Ile Pro Pro Thr 1 5 <210> 873 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 873 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccaggaaagg ggctggagtg ggtctcaggt attagtggta gtggcactca cacatactac 180 acagactccg tgaagggccg gttcaccatc tccagagaca attccaagga caggctctat 240 ctgcaaatga acagtctgag agccgaagac acggccgtat attactgtgc gaaagagggc 300 ctcctctatt atttcaattt ctggggccgt ggcaccacgg tcaccgtctc ctca 354 <210> 874 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 874 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Thr His Thr Tyr Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Arg Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Gly Leu Leu Tyr Tyr Phe Asn Phe Trp Gly Arg Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 875 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 875 ggattcacct ttagcagcta tgcc 24 <210> 876 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 876 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 877 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 877 attagtggta gtggcactca caca 24 <210> 878 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 878 Ile Ser Gly Ser Gly Thr His Thr 1 5 <210> 879 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 879 gcgaaagagg gcctcctcta ttatttcaat ttc 33 <210> 880 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 880 Ala Lys Glu Gly Leu Leu Tyr Tyr Phe Asn Phe 1 5 10 <210> 881 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 881 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactg ctgtcaacag agttacagta ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 882 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 882 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 883 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 883 cagagcatta gcagctat 18 <210> 884 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 884 Gln Ser Ile Ser Ser Tyr 1 5 <210> 885 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 885 gctgcatcc 9 <210> 886 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 886 Ala Ala Ser 1 <210> 887 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 887 caacagagtt acagtacccc attcact 27 <210> 888 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 888 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 889 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 889 gaggtgcagc tggtggagtc tgggggggac ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag tctagactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac acggccttgt attactgtgc aaaagatacg 300 ggtatagcag caggtgccga ctactactac ggtctggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 890 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 890 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Leu Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Thr Gly Ile Ala Ala Gly Ala Asp Tyr Tyr Tyr Gly Leu 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 891 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 891 ggattcacct ttgatgatta tgcc 24 <210> 892 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 892 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 893 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 893 attagttgga atagtggtag tcta 24 <210> 894 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 894 Ile Ser Trp Asn Ser Gly Ser Leu 1 5 <210> 895 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 895 gcaaaagata cgggtatagc agcaggtgcc gactactact acggtctgga cgtc 54 <210> 896 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 896 Ala Lys Asp Thr Gly Ile Ala Ala Gly Ala Asp Tyr Tyr Tyr Gly Leu 1 5 10 15 Asp Val <210> 897 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 897 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattacc aattttttag cctggtatca gcagatacca 120 gggagagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa ccttcagcct 240 gaagatgttg caacttatta ctgtcaaacc tataacagtg ccccgctcac tttcggcggg 300 gggaccaagg tggagatcaa acga 324 <210> 898 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 898 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Asn Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Ile Pro Gly Arg Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Thr Tyr Asn Ser Ala Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 899 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 899 cagggcatta ccaatttt 18 <210> 900 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 900 Gln Gly Ile Thr Asn Phe 1 5 <210> 901 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 901 gctgcatcc 9 <210> 902 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 902 Ala Ala Ser 1 <210> 903 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 903 caaacctata acagtgcccc gctcact 27 <210> 904 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 904 Gln Thr Tyr Asn Ser Ala Pro Leu Thr 1 5 <210> 905 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 905 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt ggttacgact ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaaactta gtggaagcac caattacaat 180 ccgtccctca agagtcgagt cactatatca ctagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agtccctatg 300 actataggct actactacgg tttggacgtc tggggccagg ggaccacggt caccgtctcc 360 tca 363 <210> 906 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 906 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Asp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Lys Leu Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Val Pro Met Thr Ile Gly Tyr Tyr Tyr Gly Leu Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 907 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 907 ggtgggtcct tcagtggtta cgac 24 <210> 908 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 908 Gly Gly Ser Phe Ser Gly Tyr Asp 1 5 <210> 909 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 909 atcaaactta gtggaagcac c 21 <210> 910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 910 Ile Lys Leu Ser Gly Ser Thr 1 5 <210> 911 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 911 gcgagagtcc ctatgactat aggctactac tacggtttgg acgtc 45 <210> 912 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 912 Ala Arg Val Pro Met Thr Ile Gly Tyr Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 913 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 913 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca 120 gggaaagttc ctcagctcct gatctatgct gcatccactt tgcagtcagg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg ctacttatta ctgtcaaaag tatgccggtg cccctcggac gttcggccag 300 gggaccaagg tggagatcaa acga 324 <210> 914 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 914 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Gln Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Ala Gly Ala Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 915 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 915 cagggcatta gcaattat 18 <210> 916 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 916 Gln Gly Ile Ser Asn Tyr 1 5 <210> 917 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 917 gctgcatcc 9 <210> 918 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 918 Ala Ala Ser 1 <210> 919 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 919 caaaagtatg ccggtgcccc tcggacg 27 <210> 920 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 920 Gln Lys Tyr Ala Gly Ala Pro Arg Thr 1 5 <210> 921 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 921 caggtgcagc tggtggagtc gggcccagga ctggtgaagt cttcggcgac cctgtccctt 60 atctgcactg tctctggtgg ctccataagt agttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atcaattaca gtgggagcac caactacaac 180 ccctccctca agagtcgagt caccatttta gtagacacgt ccaagaacca cttctccctg 240 aagctgagtt ctgtgaccgt tgcggacacg gccgtatatt actgtgcgag aggggccagt 300 aaccctgatt attactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 922 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 922 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Ser Ser Ala 1 5 10 15 Thr Leu Ser Leu Ile Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Leu Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Val Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ala Ser Asn Pro Asp Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 923 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 923 ggtggctcca taagtagtta ctac 24 <210> 924 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 924 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 925 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 925 atcaattaca gtgggagcac c 21 <210> 926 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 926 Ile Asn Tyr Ser Gly Ser Thr 1 5 <210> 927 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 927 gcgagagggg ccagtaaccc tgattattac tactacggta tggacgtc 48 <210> 928 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 928 Ala Arg Gly Ala Ser Asn Pro Asp Tyr Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 929 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 929 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggcctcc 60 atcaactgca agtccagcca taatgtttta tacagctcca acaataagaa ctacttagct 120 tggtatcagc agacaccagg tcagcctcct aaattactca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg attccgtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga ggatgtggca gtttatttct gtcagcagta ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 930 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 930 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Ser Ile Asn Cys Lys Ser Ser His Asn Val Leu Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Thr Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 931 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 931 cataatgttt tatacagctc caacaataag aactac 36 <210> 932 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 932 His Asn Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 933 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 933 tgggcatct 9 <210> 934 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 934 Trp Ala Ser 1 <210> 935 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 935 cagcagtatt ataatactcc gtggacg 27 <210> 936 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 936 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 937 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 937 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc 60 tcctgtgtag cctctggatt cccctttagt agcttttgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaac atgaaacagg atggaagtga gaaatactat 180 gtggactctg tgaagggccg attcaccctc tccagagaca acggcaagaa ctcagtgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagataac 300 ttcccctttg actattgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 938 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 938 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Pro Phe Ser Ser Phe 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Met Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Gly Lys Asn Ser Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Phe Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 939 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 939 ggattcccct ttagtagctt ttgg 24 <210> 940 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 940 Gly Phe Pro Phe Ser Ser Phe Trp 1 5 <210> 941 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 941 atgaaacagg atggaagtga gaaa 24 <210> 942 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 942 Met Lys Gln Asp Gly Ser Glu Lys 1 5 <210> 943 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 943 gcgagagata acttcccctt tgactat 27 <210> 944 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 944 Ala Arg Asp Asn Phe Pro Phe Asp Tyr 1 5 <210> 945 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 945 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattagc agttatttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatgtt gcatccactt tgcaatcagg ggtcccatct 180 cggttcagtg gcagtggatc tggaacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcacaag tataacagtg ccccgtggac attcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 946 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 946 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys His Lys Tyr Asn Ser Ala Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 947 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 947 cagggcatta gcagttat 18 <210> 948 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 948 Gln Gly Ile Ser Ser Tyr 1 5 <210> 949 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 949 gttgcatcc 9 <210> 950 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 950 Val Ala Ser 1 <210> 951 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 951 cacaagtata acagtgcccc gtggaca 27 <210> 952 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 952 His Lys Tyr Asn Ser Ala Pro Trp Thr 1 5 <210> 953 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 953 caggtgcagc tggtggagtc aggtccagga ctggtgaggc cctcgcagac cctctcactc 60 acctgtgcca tctccgggga cagcgtctct accaacagtg gtgcttggaa ctgggtcagg 120 cagtccccat cgagaggcct tgagtggctg gggaggacat actacaggtc caagtggtat 180 gatgaatatg cagtatctat gaaaagtcga atgaccatca acccagacac atccaagaac 240 cagttctccc tgcagatgaa ctctgtgact cccgaggaca cggctgtcta tttctgtgca 300 agagaacgca gctggttctc tgacgctttt gatatttggg gccaagggac aatggtcacc 360 gtctcttca 369 <210> 954 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 954 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Thr Asn 20 25 30 Ser Gly Ala Trp Asn Trp Val Arg Gln Ser Pro Ser Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asp Glu Tyr Ala 50 55 60 Val Ser Met Lys Ser Arg Met Thr Ile Asn Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Met Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Phe Cys Ala Arg Glu Arg Ser Trp Phe Ser Asp Ala Phe Asp Ile 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 955 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 955 ggggacagcg tctctaccaa cagtggtgct 30 <210> 956 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 956 Gly Asp Ser Val Ser Thr Asn Ser Gly Ala 1 5 10 <210> 957 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 957 acatactaca ggtccaagtg gtatgat 27 <210> 958 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 958 Thr Tyr Tyr Arg Ser Lys Trp Tyr Asp 1 5 <210> 959 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 959 gcaagagaac gcagctggtt ctctgacgct tttgatatt 39 <210> 960 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 960 Ala Arg Glu Arg Ser Trp Phe Ser Asp Ala Phe Asp Ile 1 5 10 <210> 961 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 961 gacatccagt tgacccagtc tccttccatc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt acctggttgg cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatgag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtagatc tgggacagac ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatactt tttggacgtt cggccaaggg 300 accaaggtgg agatcaaacg a 321 <210> 962 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 962 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ile Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Phe Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 963 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 963 cagagtatta gtacctgg 18 <210> 964 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 964 Gln Ser Ile Ser Thr Trp 1 5 <210> 965 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 965 gaggcgtct 9 <210> 966 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 966 Glu Ala Ser 1 <210> 967 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 967 caacagtata atactttttg gacg 24 <210> 968 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 968 Gln Gln Tyr Asn Thr Phe Trp Thr 1 5 <210> 969 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 969 gaggtgcagc tggtggagtc tgggggaggc gtggtacagc cgggggggtc cctgagactc 60 tcctgtacaa cctctggatt catctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attaattgga atagtggaac catagactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa atccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttct attattgtat aaaggatata 300 ttagtaccag atgcatgggg gtatttcgat ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 970 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 970 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Ile Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Ser Gly Thr Ile Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 85 90 95 Ile Lys Asp Ile Leu Val Pro Asp Ala Trp Gly Tyr Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 971 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 971 ggattcatct ttgatgatta tgcc 24 <210> 972 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 972 Gly Phe Ile Phe Asp Asp Tyr Ala 1 5 <210> 973 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 973 attaattgga atagtggaac cata 24 <210> 974 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 974 Ile Asn Trp Asn Ser Gly Thr Ile 1 5 <210> 975 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 975 ataaaggata tattagtacc agatgcatgg gggtatttcg atctc 45 <210> 976 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 976 Ile Lys Asp Ile Leu Val Pro Asp Ala Trp Gly Tyr Phe Asp Leu 1 5 10 15 <210> 977 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 977 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttagc agcacctact tagcctggta ccagcagaaa 120 cctggccagt ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcaa cattatggtt actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 978 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 978 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Tyr Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 979 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 979 cagagtgtta gcagcaccta c 21 <210> 980 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 980 Gln Ser Val Ser Ser Thr Tyr 1 5 <210> 981 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 981 ggtgcatcc 9 <210> 982 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 982 Gly Ala Ser 1 <210> 983 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 983 caacattatg gttactcaaa attcact 27 <210> 984 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 984 Gln His Tyr Gly Tyr Ser Lys Phe Thr 1 5 <210> 985 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 985 gaggtgcagc tggtggagtc tgggggaggc ttggttcagc cagggcggtc cctgagactc 60 tcctgttcag ctgctggctt cacctttggt gattttgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtaggtttc attagaagca acacttatgg tgggacaaca 180 gaatacgccg tgtctgtgag aggcagattc accatctcaa gagatgattc caaaaatatc 240 gcctatctgc aaatgaatag cctgaaaacc gaggacacag ccgtgtattt ctgtactaga 300 gagggcaggg actacggtga ctacgttctt gactactggg gccagggaac cctggtcacc 360 gtctcctca 369 <210> 986 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 986 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ala Gly Phe Thr Phe Gly Asp Phe 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Phe Ile Arg Ser Asn Thr Tyr Gly Gly Thr Thr Glu Tyr Ala Val 50 55 60 Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 65 70 75 80 Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Phe Cys Thr Arg Glu Gly Arg Asp Tyr Gly Asp Tyr Val Leu Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 987 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 987 ggcttcacct ttggtgattt tgct 24 <210> 988 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 988 Gly Phe Thr Phe Gly Asp Phe Ala 1 5 <210> 989 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 989 attagaagca acacttatgg tgggacaaca 30 <210> 990 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 990 Ile Arg Ser Asn Thr Tyr Gly Gly Thr Thr 1 5 10 <210> 991 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 991 actagagagg gcagggacta cggtgactac gttcttgact ac 42 <210> 992 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 992 Thr Arg Glu Gly Arg Asp Tyr Gly Asp Tyr Val Leu Asp Tyr 1 5 10 <210> 993 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 993 gacatccaga tgacccagtc tccatcctcc ctgtttgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatctt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatt tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caatttatta ctgtctacaa gatttcactt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 994 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 994 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Phe Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Leu Gln Asp Phe Thr Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 995 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 995 caggacatta gaaatgat 18 <210> 996 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 996 Gln Asp Ile Arg Asn Asp 1 5 <210> 997 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 997 cttgcatcc 9 <210> 998 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 998 Leu Ala Ser 1 <210> 999 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 999 ctacaagatt tcacttaccc gtggacg 27 <210> 1000 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1000 Leu Gln Asp Phe Thr Tyr Pro Trp Thr 1 5 <210> 1001 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1001 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag tatggactat 180 gcggactctg tgaagggccg attcaccatt tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttat attactgtat aaaagatata 300 ttagtagcag atgcatgggg gtggttcgat ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1002 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1002 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ile Lys Asp Ile Leu Val Ala Asp Ala Trp Gly Trp Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1003 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1003 ggattcacct ttgatgatta tgcc 24 <210> 1004 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1004 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 1005 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1005 attagttgga atagtggtag tatg 24 <210> 1006 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1006 Ile Ser Trp Asn Ser Gly Ser Met 1 5 <210> 1007 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1007 ataaaagata tattagtagc agatgcatgg gggtggttcg atctc 45 <210> 1008 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1008 Ile Lys Asp Ile Leu Val Ala Asp Ala Trp Gly Trp Phe Asp Leu 1 5 10 15 <210> 1009 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1009 gacattgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttagc agcagctacc taacctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta tttctgtcag cactatgtta actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1010 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1010 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln His Tyr Val Asn Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1011 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1011 cagagtgtta gcagcagcta c 21 <210> 1012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1012 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 1013 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1013 ggtgcatcc 9 <210> 1014 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1014 Gly Ala Ser 1 <210> 1015 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1015 cagcactatg ttaactcaaa attcact 27 <210> 1016 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1016 Gln His Tyr Val Asn Ser Lys Phe Thr 1 5 <210> 1017 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1017 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctaatgg ctccatcagt acttactatt ggagctggat acggcagccc 120 ccagggaagg gactggagtg gattgggtat gtctattaca gtgggaggac caactacaat 180 ccctccctca agagtcgagt catcatatca gtagacacgc ccaagaacca gttctccctg 240 aaactgagtt ctgtgaccgc tgcagacacg gccgtgtatt actgtgcgcg agatcttcat 300 atagcagtgg gtggctactg gtacttcgat ttctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1018 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1018 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Val Tyr Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ser Val Asp Thr Pro Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu His Ile Ala Val Gly Gly Tyr Trp Tyr Phe Asp Phe Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1019 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1019 aatggctcca tcagtactta ctat 24 <210> 1020 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1020 Asn Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1021 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1021 gtctattaca gtgggaggac c 21 <210> 1022 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1022 Val Tyr Tyr Ser Gly Arg Thr 1 5 <210> 1023 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1023 gcgcgagatc ttcatatagc agtgggtggc tactggtact tcgatttc 48 <210> 1024 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1024 Ala Arg Asp Leu His Ile Ala Val Gly Gly Tyr Trp Tyr Phe Asp Phe 1 5 10 15 <210> 1025 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1025 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattaac aactatttga attggtatca gcagaaacca 120 gggaaggccc ctaagctcct gatctatgct gcatccactt tacaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacaact ttcactctca ccatcaacag tctgcaacct 240 gaagattttg caacttactt ctgtcaacaa atttacagta tcccgatcac cttcggccag 300 gggaccaaac tggagatcaa acga 324 <210> 1026 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1026 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Thr Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ile Tyr Ser Ile Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 1027 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1027 cagagcatta acaactat 18 <210> 1028 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1028 Gln Ser Ile Asn Asn Tyr 1 5 <210> 1029 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1029 gctgcatcc 9 <210> 1030 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1030 Ala Ala Ser 1 <210> 1031 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1031 caacaaattt acagtatccc gatcacc 27 <210> 1032 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1032 Gln Gln Ile Tyr Ser Ile Pro Ile Thr 1 5 <210> 1033 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1033 caggtgcagc tggtggagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60 acctgtgcca tctccgggga cagtgtctct accaacagtg gtgcttggaa ctggatcagg 120 cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat 180 aatgactatg cagcatctgt gaaaagtcga ataaccatca gcccagacac atccaagaac 240 cagttctccc tgcagatgaa ctctgtgact cccgaggaca cggctgtgta tttctgtgca 300 agagaacgca gctggttctc tgacgctttt gatatctggg gccaagggac aatggtcacc 360 gtctcctca 369 <210> 1034 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1034 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Thr Asn 20 25 30 Ser Gly Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 50 55 60 Ala Ser Val Lys Ser Arg Ile Thr Ile Ser Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Met Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Phe Cys Ala Arg Glu Arg Ser Trp Phe Ser Asp Ala Phe Asp Ile 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 1035 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1035 ggggacagtg tctctaccaa cagtggtgct 30 <210> 1036 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1036 Gly Asp Ser Val Ser Thr Asn Ser Gly Ala 1 5 10 <210> 1037 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1037 acatactaca ggtccaagtg gtataat 27 <210> 1038 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1038 Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 1 5 <210> 1039 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1039 gcaagagaac gcagctggtt ctctgacgct tttgatatc 39 <210> 1040 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1040 Ala Arg Glu Arg Ser Trp Phe Ser Asp Ala Phe Asp Ile 1 5 10 <210> 1041 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1041 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaaa cagaatcacc 60 atcacttgcc gggccagtca gagtattagt gcctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatactt attggacgtt cggccaaggg 300 accaaggtgg agatcaaacg a 321 <210> 1042 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1042 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asn Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ala Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1043 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1043 cagagtatta gtgcctgg 18 <210> 1044 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1044 Gln Ser Ile Ser Ala Trp 1 5 <210> 1045 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1045 aaggcgtct 9 <210> 1046 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1046 Lys Ala Ser 1 <210> 1047 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1047 caacagtata atacttattg gacg 24 <210> 1048 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1048 Gln Gln Tyr Asn Thr Tyr Trp Thr 1 5 <210> 1049 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1049 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagcg 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatta tatagactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctgtat 240 ctgcagatga acagtctgag atctgaggac acggccctgt attactgtgc aaaagatata 300 ttactaccag atgcatgggg gtggttcgat ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1050 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1050 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Tyr Ile Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Leu Leu Pro Asp Ala Trp Gly Trp Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1051 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1051 ggattcacct ttgatgatta tgcc 24 <210> 1052 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1052 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 1053 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1053 attagttgga atagtgatta tata 24 <210> 1054 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1054 Ile Ser Trp Asn Ser Asp Tyr Ile 1 5 <210> 1055 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1055 gcaaaagata tattactacc agatgcatgg gggtggttcg atctc 45 <210> 1056 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1056 Ala Lys Asp Ile Leu Leu Pro Asp Ala Trp Gly Trp Phe Asp Leu 1 5 10 15 <210> 1057 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1057 gacatcgtga tgacccagtc tccagacacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gcgtgttagc agtagctact taacctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 tctgaagatt ctgcagtgta ttactgccag cattttgtta actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1058 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1058 Asp Ile Val Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 20 25 30 Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Ser Glu Asp Ser Ala Val Tyr Tyr Cys Gln His Phe Val Asn Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1059 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1059 cagcgtgtta gcagtagcta c 21 <210> 1060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1060 Gln Arg Val Ser Ser Ser Tyr 1 5 <210> 1061 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1061 ggtgcatcc 9 <210> 1062 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1062 Gly Ala Ser 1 <210> 1063 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1063 cagcattttg ttaactcaaa attcact 27 <210> 1064 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1064 Gln His Phe Val Asn Ser Lys Phe Thr 1 5 <210> 1065 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1065 caggtgcagc tggtggagtc tgggggaggc ttggttcagc cagggcggtc cctgagactc 60 tcctgttcag ctgctggatt cacctttggt gattttgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtaggtttc attagaagca acacttatgg tgggacaaca 180 gaatacgccg tgtctgtgag aggcagattc accatctcaa gagatgattc caaaaatatc 240 gcctatctgc aaatgaatag cctgaaaacc gaggacacag ccgtgtatta ctgtactaga 300 gagggcaggg actacggtga ctacgttctt gactactggg gccagggaac catggtcacc 360 gtctcctca 369 <210> 1066 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1066 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ala Gly Phe Thr Phe Gly Asp Phe 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Phe Ile Arg Ser Asn Thr Tyr Gly Gly Thr Thr Glu Tyr Ala Val 50 55 60 Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 65 70 75 80 Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Arg Glu Gly Arg Asp Tyr Gly Asp Tyr Val Leu Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 1067 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1067 ggattcacct ttggtgattt tgct 24 <210> 1068 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1068 Gly Phe Thr Phe Gly Asp Phe Ala 1 5 <210> 1069 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1069 attagaagca acacttatgg tgggacaaca 30 <210> 1070 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1070 Ile Arg Ser Asn Thr Tyr Gly Gly Thr Thr 1 5 10 <210> 1071 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1071 actagagagg gcagggacta cggtgactac gttcttgact ac 42 <210> 1072 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1072 Thr Arg Glu Gly Arg Asp Tyr Gly Asp Tyr Val Leu Asp Tyr 1 5 10 <210> 1073 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1073 gacatcctga tgacccagtc tccatcctcc ctgtgtgtat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatctt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatt tggcacagat ttcagtctca ccatcagcag cctgcagcct 240 gaagattttg caatttacta ctgtctacaa gatttcactt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 1074 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1074 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Cys Val Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Leu Gln Asp Phe Thr Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1075 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1075 caggacatta gaaatgat 18 <210> 1076 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1076 Gln Asp Ile Arg Asn Asp 1 5 <210> 1077 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1077 cttgcatcc 9 <210> 1078 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1078 Leu Ala Ser 1 <210> 1079 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1079 ctacaagatt tcacttaccc gtggacg 27 <210> 1080 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1080 Leu Gln Asp Phe Thr Tyr Pro Trp Thr 1 5 <210> 1081 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1081 caggtgcagc tggtggagtc tgggggaggc gtggtacagc cgggggggtc cctgagactc 60 tcctgtacaa cctctggatt catctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attaattgga atagtggaac catagactat 180 gcagactcgg tgaagggccg attcaccatc tccagagaca acgccaagaa atccctgtat 240 cttcaaatga acagtctgag agctgaggac acggccttct attattgtat aaaggatata 300 ttagtaccag atgcatgggg gtatttcgat atttggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1082 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1082 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Ile Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Ser Gly Thr Ile Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 85 90 95 Ile Lys Asp Ile Leu Val Pro Asp Ala Trp Gly Tyr Phe Asp Ile Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1083 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1083 ggattcatct ttgatgatta tgcc 24 <210> 1084 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1084 Gly Phe Ile Phe Asp Asp Tyr Ala 1 5 <210> 1085 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1085 attaattgga atagtggaac cata 24 <210> 1086 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1086 Ile Asn Trp Asn Ser Gly Thr Ile 1 5 <210> 1087 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1087 ataaaggata tattagtacc agatgcatgg gggtatttcg atatt 45 <210> 1088 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1088 Ile Lys Asp Ile Leu Val Pro Asp Ala Trp Gly Tyr Phe Asp Ile 1 5 10 15 <210> 1089 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1089 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttagc agcacctact tagcctggta ccagcagaaa 120 cctggccagt ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcaa cattatggtt actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1090 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1090 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Tyr Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1091 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1091 cagagtgtta gcagcaccta c 21 <210> 1092 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1092 Gln Ser Val Ser Ser Thr Tyr 1 5 <210> 1093 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1093 ggtgcatcc 9 <210> 1094 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1094 Gly Ala Ser 1 <210> 1095 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1095 caacattatg gttactcaaa attcact 27 <210> 1096 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1096 Gln His Tyr Gly Tyr Ser Lys Phe Thr 1 5 <210> 1097 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1097 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttgat gattatggca tgcactgggt ccggcaagcg 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgataa tatggactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatgc aaaatctgag atcagaggac acggccctgt attactgtgc aaaagatata 300 ttagttccag atgcatgggg gtggttcgat ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1098 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1098 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Asn Met Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Gln Asn Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Leu Val Pro Asp Ala Trp Gly Trp Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1099 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1099 ggattcacct ttgatgatta tggc 24 <210> 1100 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1100 Gly Phe Thr Phe Asp Asp Tyr Gly 1 5 <210> 1101 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1101 attagttgga atagtgataa tatg 24 <210> 1102 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1102 Ile Ser Trp Asn Ser Asp Asn Met 1 5 <210> 1103 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1103 gcaaaagata tattagttcc agatgcatgg gggtggttcg atctc 45 <210> 1104 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1104 Ala Lys Asp Ile Leu Val Pro Asp Ala Trp Gly Trp Phe Asp Leu 1 5 10 15 <210> 1105 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1105 gacatcgtga tgacccagtc tccagacacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gcgtgttagc agcagccact taacctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcttt ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtata ttactgtcag cattttgtta actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1106 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1106 Asp Ile Val Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 20 25 30 His Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Phe Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Phe Val Asn Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1107 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1107 cagcgtgtta gcagcagcca c 21 <210> 1108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1108 Gln Arg Val Ser Ser Ser His 1 5 <210> 1109 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1109 ggtgcatcc 9 <210> 1110 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1110 Gly Ala Ser 1 <210> 1111 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1111 cagcattttg ttaactcaaa attcact 27 <210> 1112 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1112 Gln His Phe Val Asn Ser Lys Phe Thr 1 5 <210> 1113 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1113 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagc acttactatt ggagctggat acggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaggac caactacaat 180 ccctccctca agagtcgagt catcatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgagtt ctgtgaccgc tgcagacacg gccgtgtatt actgtgcgcg agatcttcat 300 atagcagtgg gtggctactg gttcttcgat ttctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1114 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1114 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu His Ile Ala Val Gly Gly Tyr Trp Phe Phe Asp Phe Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1115 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1115 ggtggctcca tcagcactta ctat 24 <210> 1116 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1116 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1117 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1117 atctattaca gtgggaggac c 21 <210> 1118 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1118 Ile Tyr Tyr Ser Gly Arg Thr 1 5 <210> 1119 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1119 gcgcgagatc ttcatatagc agtgggtggc tactggttct tcgatttc 48 <210> 1120 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1120 Ala Arg Asp Leu His Ile Ala Val Gly Gly Tyr Trp Phe Phe Asp Phe 1 5 10 15 <210> 1121 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1121 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc ggacaagtca gagcattaac aactatttga attggtatca gcagaaacca 120 gggaaggccc ctaacctcct gatctatgct gcatccactt tacaaactgg ggtcccatca 180 cggttcagtg gcagtggatc tgggacaact ttcactctca ccatcaacag tctgcaacct 240 gaagattttg caacttactt ctgtcagcaa atttacagtc tcccgatcac cttcggccag 300 gggacacgac tggagattaa acga 324 <210> 1122 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1122 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Asn Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Thr Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ile Tyr Ser Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 1123 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1123 cagagcatta acaactat 18 <210> 1124 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1124 Gln Ser Ile Asn Asn Tyr 1 5 <210> 1125 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1125 gctgcatcc 9 <210> 1126 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1126 Ala Ala Ser 1 <210> 1127 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1127 cagcaaattt acagtctccc gatcacc 27 <210> 1128 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1128 Gln Gln Ile Tyr Ser Leu Pro Ile Thr 1 5 <210> 1129 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1129 caggtgcagc tggtggagtc tgggggaggc ttggttcagc cagggcggtc cctgagactc 60 tcctgttcag ctgctggatt cacctttggt gattttgcta tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtaggtttc attagaagca acacttatgg tgggacaaca 180 gaatacgccg tgtctgtgag aggcagattc accatctcaa gagatgattc caaaaatatc 240 gcctatctgc aaatgaatag cctgaaaacc gaggacacag ccgtgtatta ctgtactaga 300 gagggcaggg actacggtga ctacgttctt gactactggg gccagggaac cctggtcacc 360 gtctcctca 369 <210> 1130 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1130 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ala Gly Phe Thr Phe Gly Asp Phe 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Phe Ile Arg Ser Asn Thr Tyr Gly Gly Thr Thr Glu Tyr Ala Val 50 55 60 Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 65 70 75 80 Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Arg Glu Gly Arg Asp Tyr Gly Asp Tyr Val Leu Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1131 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1131 ggattcacct ttggtgattt tgct 24 <210> 1132 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1132 Gly Phe Thr Phe Gly Asp Phe Ala 1 5 <210> 1133 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1133 attagaagca acacttatgg tgggacaaca 30 <210> 1134 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1134 Ile Arg Ser Asn Thr Tyr Gly Gly Thr Thr 1 5 10 <210> 1135 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1135 actagagagg gcagggacta cggtgactac gttcttgact ac 42 <210> 1136 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1136 Thr Arg Glu Gly Arg Asp Tyr Gly Asp Tyr Val Leu Asp Tyr 1 5 10 <210> 1137 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1137 gacatcctga tgacccagtc tccatcctcc ctgtttgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatctt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatt tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caatttatta ctgtctacaa gatttcactt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 1138 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1138 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Phe Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Leu Gln Asp Phe Thr Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1139 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1139 caggacatta gaaatgat 18 <210> 1140 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1140 Gln Asp Ile Arg Asn Asp 1 5 <210> 1141 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1141 cttgcatcc 9 <210> 1142 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1142 Leu Ala Ser 1 <210> 1143 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1143 ctacaagatt tcacttaccc gtggacg 27 <210> 1144 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1144 Leu Gln Asp Phe Thr Tyr Pro Trp Thr 1 5 <210> 1145 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1145 caggtgcagc tggtgcagtc aggtccagaa ctggtgaggc cctcgcagac cctctcactc 60 acctgtgcca tctccgggga cagtgtctct accaacagtg gtgcttggaa ctggatcagg 120 cagtccccat cgagaggcct tgagtggctg ggaaggacat attataggtc caagtggtat 180 gaagaatatg cagtatctgt gagaggtcga ataaccatca gcccagacac atccaagaac 240 cagttctccc tgcagatgaa ctctgtgact cccgaggaca cggctgtgta tttctgtgca 300 agagaacgca gctggttctc tgacgctttt gatctttggg gccaagggac aatggtcacc 360 gtctcttca 369 <210> 1146 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1146 Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Val Arg Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Thr Asn 20 25 30 Ser Gly Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Glu Glu Tyr Ala 50 55 60 Val Ser Val Arg Gly Arg Ile Thr Ile Ser Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Met Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Phe Cys Ala Arg Glu Arg Ser Trp Phe Ser Asp Ala Phe Asp Leu 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 1147 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1147 ggggacagtg tctctaccaa cagtggtgct 30 <210> 1148 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1148 Gly Asp Ser Val Ser Thr Asn Ser Gly Ala 1 5 10 <210> 1149 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1149 acatattata ggtccaagtg gtatgaa 27 <210> 1150 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1150 Thr Tyr Tyr Arg Ser Lys Trp Tyr Glu 1 5 <210> 1151 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1151 gcaagagaac gcagctggtt ctctgacgct tttgatctt 39 <210> 1152 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1152 Ala Arg Glu Arg Ser Trp Phe Ser Asp Ala Phe Asp Leu 1 5 10 <210> 1153 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1153 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatgag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtagatc tgggacagac ttcactctca ctatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatactt attggacgtt cggccaaggg 300 accaaggtgg agatcaaacg a 321 <210> 1154 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1154 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1155 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1155 cagagtatta gtagctgg 18 <210> 1156 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1156 Gln Ser Ile Ser Ser Trp 1 5 <210> 1157 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1157 gaggcgtct 9 <210> 1158 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1158 Glu Ala Ser 1 <210> 1159 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1159 caacagtata atacttattg gacg 24 <210> 1160 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1160 Gln Gln Tyr Asn Thr Tyr Trp Thr 1 5 <210> 1161 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1161 gaggtgcagc tggtggagtc cgggggaggc ttgggacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagtt 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgatac cctaggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctttat 240 ctgcaaatga acagtctgag acctgaggac acggccatat attactgtgc aaaggataca 300 ttagtaccag atgattgggg gtatttcgct ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1162 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1162 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Gly Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Thr Leu Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Lys Asp Thr Leu Val Pro Asp Asp Trp Gly Tyr Phe Ala Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1163 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1163 ggattcacct ttgatgatta tgcc 24 <210> 1164 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1164 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 1165 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1165 attagttgga atagtgatac ccta 24 <210> 1166 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1166 Ile Ser Trp Asn Ser Asp Thr Leu 1 5 <210> 1167 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1167 gcaaaggata cattagtacc agatgattgg gggtatttcg ctctc 45 <210> 1168 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1168 Ala Lys Asp Thr Leu Val Pro Asp Asp Trp Gly Tyr Phe Ala Leu 1 5 10 15 <210> 1169 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1169 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagt agcaactact taacctggta ccagcagaga 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgtt ttactgtcag cactatggtt actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1170 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1170 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Thr Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln His Tyr Gly Tyr Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1171 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1171 cagagtgtta gtagcaacta c 21 <210> 1172 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1172 Gln Ser Val Ser Ser Asn Tyr 1 5 <210> 1173 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1173 ggtgcatcc 9 <210> 1174 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1174 Gly Ala Ser 1 <210> 1175 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1175 cagcactatg gttactcaaa attcact 27 <210> 1176 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1176 Gln His Tyr Gly Tyr Ser Lys Phe Thr 1 5 <210> 1177 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1177 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt cacctttagc acctctgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtagta gtggtggtag cacatactac 180 gcagactccg tgaggggccg tttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgttt attactgtgc ggagggcagt 300 ggctggtact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 1178 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1178 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Thr Ser 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly Ser Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 1179 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1179 ggattcacct ttagcacctc tgcc 24 <210> 1180 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1180 Gly Phe Thr Phe Ser Thr Ser Ala 1 5 <210> 1181 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1181 attagtagta gtggtggtag caca 24 <210> 1182 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1182 Ile Ser Ser Ser Gly Gly Ser Thr 1 5 <210> 1183 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1183 gcggagggca gtggctggta ctactttgac tac 33 <210> 1184 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1184 Ala Glu Gly Ser Gly Trp Tyr Tyr Phe Asp Tyr 1 5 10 <210> 1185 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1185 gaaatcgtga tgacccagtc tccaggcacc atgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaactact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggaa 240 cctgaagatt ttgcagtgta tttctgtcag caatatggta gctcaccgct cactttcggc 300 ggagggacca aggtggagat caaacga 327 <210> 1186 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1186 Glu Ile Val Met Thr Gln Ser Pro Gly Thr Met Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1187 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1187 cagagtgtta gcagcaacta c 21 <210> 1188 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1188 Gln Ser Val Ser Ser Asn Tyr 1 5 <210> 1189 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1189 ggtgcatcc 9 <210> 1190 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1190 Gly Ala Ser 1 <210> 1191 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1191 cagcaatatg gtagctcacc gctcact 27 <210> 1192 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1192 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1193 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1193 gaggtgcagc tggtggagtc tgggggaggc gtggtacagc cgggggggtc cctgagactc 60 tcctgtaaaa cctctggatt catctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attaattgga atagtggaac catagactat 180 tcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa atccctgtat 240 ctccaaatga acagtctgag atctgaggac acggccttgt attattgtat aaaagatata 300 ttagtgccag atgcatgggg gcatttcgat atttggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1194 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1194 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Lys Thr Ser Gly Phe Ile Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Ser Gly Thr Ile Asp Tyr Ser Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ile Lys Asp Ile Leu Val Pro Asp Ala Trp Gly His Phe Asp Ile Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1195 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1195 ggattcatct ttgatgatta tgcc 24 <210> 1196 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1196 Gly Phe Ile Phe Asp Asp Tyr Ala 1 5 <210> 1197 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1197 attaattgga atagtggaac cata 24 <210> 1198 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1198 Ile Asn Trp Asn Ser Gly Thr Ile 1 5 <210> 1199 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1199 ataaaagata tattagtgcc agatgcatgg gggcatttcg atatt 45 <210> 1200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1200 Ile Lys Asp Ile Leu Val Pro Asp Ala Trp Gly His Phe Asp Ile 1 5 10 15 <210> 1201 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1201 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttagc agcacctact tagcctggta ccagcagaaa 120 cctggccagt ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcaa cattatggtt actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1202 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1202 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Tyr Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1203 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1203 cagagtgtta gcagcaccta c 21 <210> 1204 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1204 Gln Ser Val Ser Ser Thr Tyr 1 5 <210> 1205 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1205 ggtgcatcc 9 <210> 1206 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1206 Gly Ala Ser 1 <210> 1207 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1207 caacattatg gttactcaaa attcact 27 <210> 1208 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1208 Gln His Tyr Gly Tyr Ser Lys Phe Thr 1 5 <210> 1209 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1209 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagcg 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgataa tgtagactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag atctgaggac acggccctgt attactgtac aaaagatata 300 ctagtaccgg attcatgggg gtggttcgat ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1210 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1210 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Asn Val Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Thr Lys Asp Ile Leu Val Pro Asp Ser Trp Gly Trp Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1211 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1211 ggattcacct ttgatgatta tgcc 24 <210> 1212 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1212 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 1213 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1213 attagttgga atagtgataa tgta 24 <210> 1214 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1214 Ile Ser Trp Asn Ser Asp Asn Val 1 5 <210> 1215 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1215 acaaaagata tactagtacc ggattcatgg gggtggttcg atctc 45 <210> 1216 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1216 Thr Lys Asp Ile Leu Val Pro Asp Ser Trp Gly Trp Phe Asp Leu 1 5 10 15 <210> 1217 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1217 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtct gagcattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggctc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagtg tccctccgat caccttcggc 300 caggggacca aactggagat caaacga 327 <210> 1218 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1218 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Leu Ser Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Val Pro Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 1219 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1219 ctgagcatta gcaactat 18 <210> 1220 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1220 Leu Ser Ile Ser Asn Tyr 1 5 <210> 1221 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1221 gctgcatcc 9 <210> 1222 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1222 Ala Ala Ser 1 <210> 1223 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1223 caacagagtt acagtgtccc tccgatcacc 30 <210> 1224 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1224 Gln Gln Ser Tyr Ser Val Pro Pro Ile Thr 1 5 10 <210> 1225 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1225 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt taggcaagcg 120 ccagggaagg gcctagagtg ggtctcaggt attagttgga atagtgatga tgtagactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag atctgaggac acggccctgt attactgtgc aaaagatata 300 ttattaccag atgcatgggg gtggttcgat ctctggggcc gtggcacccc ggtcaccgtc 360 tcctca 366 <210> 1226 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1226 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Asp Val Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Leu Leu Pro Asp Ala Trp Gly Trp Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Pro Val Thr Val Ser Ser 115 120 <210> 1227 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1227 ggattcacct ttgatgatta tgcc 24 <210> 1228 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1228 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 1229 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1229 attagttgga atagtgatga tgta 24 <210> 1230 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1230 Ile Ser Trp Asn Ser Asp Asp Val 1 5 <210> 1231 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1231 gcaaaagata tattattacc agatgcatgg gggtggttcg atctc 45 <210> 1232 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1232 Ala Lys Asp Ile Leu Leu Pro Asp Ala Trp Gly Trp Phe Asp Leu 1 5 10 15 <210> 1233 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1233 gacatcgtga tgacccagtc tccagacacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gcgtgttagc atcagctact taacctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtata ttactgtcag cattttgtta actcaaaatt cattttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1234 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1234 Asp Ile Val Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ile Ser 20 25 30 Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Phe Val Asn Ser Lys 85 90 95 Phe Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1235 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1235 cagcgtgtta gcatcagcta c 21 <210> 1236 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1236 Gln Arg Val Ser Ile Ser Tyr 1 5 <210> 1237 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1237 ggtgcatcc 9 <210> 1238 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1238 Gly Ala Ser 1 <210> 1239 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1239 cagcattttg ttaactcaaa attcatt 27 <210> 1240 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1240 Gln His Phe Val Asn Ser Lys Phe Ile 1 5 <210> 1241 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1241 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagcg 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtgataa tgtagactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag atctgaggac acggccctgt attactgtac aaaagatata 300 ctagtaccgg attcatgggg gtggttcgat ctctggggcc gtggcaccct ggtcaccgtc 360 tcctca 366 <210> 1242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1242 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Asn Val Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Thr Lys Asp Ile Leu Val Pro Asp Ser Trp Gly Trp Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1243 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1243 ggattcacct ttgatgatta tgcc 24 <210> 1244 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1244 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 1245 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1245 attagttgga atagtgataa tgta 24 <210> 1246 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1246 Ile Ser Trp Asn Ser Asp Asn Val 1 5 <210> 1247 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1247 acaaaagata tactagtacc ggattcatgg gggtggttcg atctc 45 <210> 1248 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1248 Thr Lys Asp Ile Leu Val Pro Asp Ser Trp Gly Trp Phe Asp Leu 1 5 10 15 <210> 1249 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1249 gacatcgtga tgacccagtc tccagacacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gcgtgttagc agcagccact taacctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcactata ttactgtcaa cattttgtta actcaaaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 1250 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1250 Asp Ile Val Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 20 25 30 His Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln His Phe Val Asn Ser Lys 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1251 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1251 cagcgtgtta gcagcagcca c 21 <210> 1252 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1252 Gln Arg Val Ser Ser Ser His 1 5 <210> 1253 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1253 ggtgcatcc 9 <210> 1254 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1254 Gly Ala Ser 1 <210> 1255 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1255 caacattttg ttaactcaaa attcact 27 <210> 1256 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1256 Gln His Phe Val Asn Ser Lys Phe Thr 1 5 <210> 1257 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1257 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagagtc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaggg ggctggagtg ggtctcaggt attagtggtg gtagcggtag tacatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag aggcgaggac acggccgtat attactgtgc gaggtggcaa 300 cgattagagg actggttcga cccctggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 1258 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1258 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 1259 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1259 ggattcacct ttagcagcta tgcc 24 <210> 1260 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1260 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 1261 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1261 attagtggtg gtagcggtag taca 24 <210> 1262 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1262 Ile Ser Gly Gly Ser Gly Ser Thr 1 5 <210> 1263 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1263 gcgaggtggc aacgattaga ggactggttc gacccc 36 <210> 1264 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1264 Ala Arg Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro 1 5 10 <210> 1265 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1265 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaacattttg caacttactt ttgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1266 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1266 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu His Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1267 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1267 cagagcatta gcagctat 18 <210> 1268 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1268 Gln Ser Ile Ser Ser Tyr 1 5 <210> 1269 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1269 gctgcatcc 9 <210> 1270 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1270 Ala Ala Ser 1 <210> 1271 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1271 caacagagtt acagtacccc gtacact 27 <210> 1272 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1272 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 1273 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1273 caggtgcagc tggtggagtc tggtcctgcg ctggtgagac ccacacagac cctcacactg 60 acctgcacct tctctgggtt ctcactcacc actagtggaa tgtgtgtgac ctggatccgt 120 cagcccccag ggaagaccct ggagtggctt gcacgcattg attgggatga tgataaatac 180 tacaacacat ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtt 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggatc 300 cacggtgact acgcccacta ctactacggt ttggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 1274 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1274 Gln Val Gln Leu Val Glu Ser Gly Pro Ala Leu Val Arg Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Cys Val Thr Trp Ile Arg Gln Pro Pro Gly Lys Thr Leu Glu 35 40 45 Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile His Gly Asp Tyr Ala His Tyr Tyr Tyr Gly Leu Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1275 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1275 gggttctcac tcaccactag tggaatgtgt 30 <210> 1276 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1276 Gly Phe Ser Leu Thr Thr Ser Gly Met Cys 1 5 10 <210> 1277 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1277 attgattggg atgatgataa a 21 <210> 1278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1278 Ile Asp Trp Asp Asp Asp Lys 1 5 <210> 1279 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1279 gcacggatcc acggtgacta cgcccactac tactacggtt tggacgtc 48 <210> 1280 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1280 Ala Arg Ile His Gly Asp Tyr Ala His Tyr Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 1281 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1281 gacatcctga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca 120 gggaaagccc ctaagtccct aatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aaattcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgccaacaa tataatagtt acccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1282 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1282 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1283 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1283 cagggcatta gcaattat 18 <210> 1284 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1284 Gln Gly Ile Ser Asn Tyr 1 5 <210> 1285 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1285 gctgcatcc 9 <210> 1286 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1286 Ala Ala Ser 1 <210> 1287 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1287 caacaatata atagttaccc gtacact 27 <210> 1288 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1288 Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 1 5 <210> 1289 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1289 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaggt attagtggta gtggtggtag ttcatattac 180 gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagag cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtac gaaagccggg 300 gagcagttcg ccctctacta ctactacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 1290 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1290 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Ser Ser Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Lys Ala Gly Glu Gln Phe Ala Leu Tyr Tyr Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1291 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1291 ggattcacct ttagcaccta tgcc 24 <210> 1292 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1292 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 1293 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1293 attagtggta gtggtggtag ttca 24 <210> 1294 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1294 Ile Ser Gly Ser Gly Gly Ser Ser 1 5 <210> 1295 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1295 acgaaagccg gggagcagtt cgccctctac tactactacg gtatggacgt c 51 <210> 1296 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1296 Thr Lys Ala Gly Glu Gln Phe Ala Leu Tyr Tyr Tyr Tyr Gly Met Asp 1 5 10 15 Val <210> 1297 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1297 gacatccaga tgacccagtc tccatccttc ctgtctgcct ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattagc agttttttag cctggtatca gcaaaaacca 120 gggaaagccc ctaagctcct gatctattct gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt atgcgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 1298 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1298 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Ala Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1299 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1299 caggacatta gcagtttt 18 <210> 1300 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1300 Gln Asp Ile Ser Ser Phe 1 5 <210> 1301 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1301 tctgcatcc 9 <210> 1302 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1302 Ser Ala Ser 1 <210> 1303 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1303 caacagctta atagttatgc gctcact 27 <210> 1304 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1304 Gln Gln Leu Asn Ser Tyr Ala Leu Thr 1 5 <210> 1305 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1305 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcaat aattactact ggagctggat ccggcagccc 120 ccaggaaagg gactggagtg gattgggtat atctattaca ttgggagcac caactacaac 180 ccctccctca agagtcgagt caccatatca gtagatacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag agaggattac 300 gatttttgga gtgcccaagg ggactactac tactacggtg tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 1306 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1306 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ile Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Asp Tyr Asp Phe Trp Ser Ala Gln Gly Asp Tyr Tyr Tyr Tyr 100 105 110 Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1307 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1307 ggtggctcca tcaataatta ctac 24 <210> 1308 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1308 Gly Gly Ser Ile Asn Asn Tyr Tyr 1 5 <210> 1309 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1309 atctattaca ttgggagcac c 21 <210> 1310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1310 Ile Tyr Tyr Ile Gly Ser Thr 1 5 <210> 1311 <211> 63 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1311 gcgagagagg attacgattt ttggagtgcc caaggggact actactacta cggtgtggac 60 gtc 63 <210> 1312 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1312 Ala Arg Glu Asp Tyr Asp Phe Trp Ser Ala Gln Gly Asp Tyr Tyr Tyr 1 5 10 15 Tyr Gly Val Asp Val 20 <210> 1313 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1313 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaggattttg caacttacta ttgtcaacag gctaacagtt tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 1314 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1314 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1315 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1315 cagggtatta gcagctgg 18 <210> 1316 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1316 Gln Gly Ile Ser Ser Trp 1 5 <210> 1317 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1317 gctgcatcc 9 <210> 1318 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1318 Ala Ala Ser 1 <210> 1319 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1319 caacaggcta acagtttccc gctcact 27 <210> 1320 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1320 Gln Gln Ala Asn Ser Phe Pro Leu Thr 1 5 <210> 1321 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1321 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cagcttcagc agctatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaggt attagtggta gtggtggtag cacatattac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaataa acagcctgag agtcgaggac acggccgtat attactgtgc gaggtggcaa 300 cgattagagg actggttcga cccctggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 1322 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1322 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 1323 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1323 ggattcagct tcagcagcta tgcc 24 <210> 1324 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1324 Gly Phe Ser Phe Ser Ser Tyr Ala 1 5 <210> 1325 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1325 attagtggta gtggtggtag caca 24 <210> 1326 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1326 Ile Ser Gly Ser Gly Gly Ser Thr 1 5 <210> 1327 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1327 gcgaggtggc aacgattaga ggactggttc gacccc 36 <210> 1328 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1328 Ala Arg Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro 1 5 10 <210> 1329 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1329 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctattct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1330 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1330 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1331 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1331 cagagcatta gcagctat 18 <210> 1332 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1332 Gln Ser Ile Ser Ser Tyr 1 5 <210> 1333 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1333 tctgcatcc 9 <210> 1334 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1334 Ser Ala Ser 1 <210> 1335 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1335 caacagagtt acagtacccc gtacact 27 <210> 1336 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1336 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 1337 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1337 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagt agttatgcca tgagttgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaggt attagtggtg gtgctggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctggaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaagtggcaa 300 cgattagagg actggttcga cccctggggc cagggaacca tggtcaccgt ctcctca 357 <210> 1338 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1338 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 1339 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1339 ggattcacct ttagtagtta tgcc 24 <210> 1340 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1340 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 1341 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1341 attagtggtg gtgctggtag caca 24 <210> 1342 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1342 Ile Ser Gly Gly Ala Gly Ser Thr 1 5 <210> 1343 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1343 gcgaagtggc aacgattaga ggactggttc gacccc 36 <210> 1344 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1344 Ala Lys Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro 1 5 10 <210> 1345 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1345 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc ggtcaagtca gagcattaac aggtatttaa attggtatca gcagaagcca 120 gggaaagccc ctaaactcct gatctatact gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1346 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1346 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Asn Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1347 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1347 cagagcatta acaggtat 18 <210> 1348 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1348 Gln Ser Ile Asn Arg Tyr 1 5 <210> 1349 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1349 actgcatcc 9 <210> 1350 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1350 Thr Ala Ser 1 <210> 1351 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1351 caacagagtt acagtacccc gtacact 27 <210> 1352 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1352 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 1353 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1353 caggtgcagc tggtggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg 60 acctgcacct tctctgggtt ctcactcagc actagtggaa tgtgtgtgaa ctggatccgt 120 cagcccccag ggaaggccct ggagtggctt acacgcattg attgggatga tgataagttc 180 tacagcacat ctctggagac caggctcacc atctccaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacggatg 300 acactagggt atagcaggtc gtctctctac tactactacg gtatggacgt ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 1354 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1354 Gln Val Gln Leu Val Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Cys Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Arg Ile Asp Trp Asp Asp Asp Lys Phe Tyr Ser Thr Ser 50 55 60 Leu Glu Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Met Thr Leu Gly Tyr Ser Arg Ser Ser Leu Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1355 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1355 gggttctcac tcagcactag tggaatgtgt 30 <210> 1356 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1356 Gly Phe Ser Leu Ser Thr Ser Gly Met Cys 1 5 10 <210> 1357 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1357 attgattggg atgatgataa g 21 <210> 1358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1358 Ile Asp Trp Asp Asp Asp Lys 1 5 <210> 1359 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1359 gcacggatga cactagggta tagcaggtcg tctctctact actactacgg tatggacgtc 60 <210> 1360 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1360 Ala Arg Met Thr Leu Gly Tyr Ser Arg Ser Ser Leu Tyr Tyr Tyr Tyr 1 5 10 15 Gly Met Asp Val 20 <210> 1361 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1361 gacatcgtga tgacccagtc tccagtctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gcatctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggaatt tattactgca tgcaagctct acaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 1362 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1362 Asp Ile Val Met Thr Gln Ser Pro Val Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 1363 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1363 cagcatctcc tgcatagtaa tggatacaac tat 33 <210> 1364 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1364 Gln His Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 1365 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1365 ttgggttct 9 <210> 1366 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1366 Leu Gly Ser 1 <210> 1367 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1367 atgcaagctc tacaaactcc gtacact 27 <210> 1368 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1368 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 1369 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1369 gaggtgcagc tggtggagtc tgggggagcc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttagc agctatgcca tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtgttaa cacatactac 180 acagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagtctgag agccgaggac acggccgtat atttctgtgc gcaaagcggg 300 gatttttgga gtggttctta tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 1370 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1370 Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Val Asn Thr Tyr Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Gln Ser Gly Asp Phe Trp Ser Gly Ser Tyr Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1371 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1371 ggattcacct ttagcagcta tgcc 24 <210> 1372 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1372 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 1373 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1373 attagtggta gtggtgttaa caca 24 <210> 1374 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1374 Ile Ser Gly Ser Gly Val Asn Thr 1 5 <210> 1375 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1375 gcgcaaagcg gggatttttg gagtggttct tatgactac 39 <210> 1376 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1376 Ala Gln Ser Gly Asp Phe Trp Ser Gly Ser Tyr Asp Tyr 1 5 10 <210> 1377 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1377 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctatact gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 1378 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1378 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1379 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1379 cagggcatta gaaatgat 18 <210> 1380 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1380 Gln Gly Ile Arg Asn Asp 1 5 <210> 1381 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1381 actgcatcc 9 <210> 1382 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1382 Thr Ala Ser 1 <210> 1383 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1383 ctacaagatt acaattaccc attcact 27 <210> 1384 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1384 Leu Gln Asp Tyr Asn Tyr Pro Phe Thr 1 5 <210> 1385 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1385 caggtgcagc tggtggagtc tgggggaggc ttagtacagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatctcagct attagtagta gtggtgttag cacatactac 180 gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcacctga acagcctgag agccgacgac acggccgtat atcactgtgc gcaaggcaac 300 agttggtact actttgatta ctggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 1386 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1386 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ser Ala Ile Ser Ser Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu His Leu Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr His Cys 85 90 95 Ala Gln Gly Asn Ser Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 1387 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1387 ggattcacct ttagcaccta tgcc 24 <210> 1388 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1388 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 1389 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1389 attagtagta gtggtgttag caca 24 <210> 1390 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1390 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 1391 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1391 gcgcaaggca acagttggta ctactttgat tac 33 <210> 1392 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1392 Ala Gln Gly Asn Ser Trp Tyr Tyr Phe Asp Tyr 1 5 10 <210> 1393 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1393 gacatcgtga tgacccagtc tccaggcacc ctgtctttct ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcggtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgctttgta ttactgtcag cagtatggtg gctcaccgat caccttcggc 300 caagggacac gactggagat taaacga 327 <210> 1394 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1394 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Phe Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 1395 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1395 cagagtgtta gcagcagcta c 21 <210> 1396 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1396 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 1397 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1397 ggtgcatcc 9 <210> 1398 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1398 Gly Ala Ser 1 <210> 1399 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1399 cagcagtatg gtggctcacc gatcacc 27 <210> 1400 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1400 Gln Gln Tyr Gly Gly Ser Pro Ile Thr 1 5 <210> 1401 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1401 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaggt attagtggta gtggtggtag ttcatattac 180 gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagag cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtac gaaagccggg 300 gagcagttcg ccctctacta ctactacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 1402 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1402 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Ser Ser Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Lys Ala Gly Glu Gln Phe Ala Leu Tyr Tyr Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1403 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1403 ggattcacct ttagcaccta tgcc 24 <210> 1404 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1404 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 1405 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1405 attagtggta gtggtggtag ttca 24 <210> 1406 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1406 Ile Ser Gly Ser Gly Gly Ser Ser 1 5 <210> 1407 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1407 acgaaagccg gggagcagtt cgccctctac tactactacg gtatggacgt c 51 <210> 1408 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1408 Thr Lys Ala Gly Glu Gln Phe Ala Leu Tyr Tyr Tyr Tyr Gly Met Asp 1 5 10 15 Val <210> 1409 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1409 gacatccaga tgacccagtc tccatccttc ctgtctgcct ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattagc agttttttag cctggtatca gcaaaaacca 120 gggaaagccc ctaagctcct gatctattct gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt atgcgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 1410 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1410 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Ala Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1411 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1411 caggacatta gcagtttt 18 <210> 1412 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1412 Gln Asp Ile Ser Ser Phe 1 5 <210> 1413 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1413 tctgcatcc 9 <210> 1414 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1414 Ser Ala Ser 1 <210> 1415 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1415 caacagctta atagttatgc gctcact 27 <210> 1416 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1416 Gln Gln Leu Asn Ser Tyr Ala Leu Thr 1 5 <210> 1417 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1417 gaggtgcagc tggtggagtc tgggggagcc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttagc agctatgcca tgacatgggt ccgccagggt 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtgttaa cacatactac 180 acagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agtcgaggac acggccgtat atttctgtgc gcaaagcggg 300 gatttttgga gtggttctta tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 1418 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1418 Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Val Asn Thr Tyr Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Gln Ser Gly Asp Phe Trp Ser Gly Ser Tyr Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1419 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1419 ggattcacct ttagcagcta tgcc 24 <210> 1420 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1420 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 1421 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1421 attagtggta gtggtgttaa caca 24 <210> 1422 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1422 Ile Ser Gly Ser Gly Val Asn Thr 1 5 <210> 1423 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1423 gcgcaaagcg gggatttttg gagtggttct tatgactac 39 <210> 1424 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1424 Ala Gln Ser Gly Asp Phe Trp Ser Gly Ser Tyr Asp Tyr 1 5 10 <210> 1425 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1425 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctatact gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 1426 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1426 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1427 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1427 cagggcatta gaaatgat 18 <210> 1428 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1428 Gln Gly Ile Arg Asn Asp 1 5 <210> 1429 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1429 actgcatcc 9 <210> 1430 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1430 Thr Ala Ser 1 <210> 1431 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1431 ctacaagatt acaattaccc attcact 27 <210> 1432 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1432 Leu Gln Asp Tyr Asn Tyr Pro Phe Thr 1 5 <210> 1433 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1433 gaggtgcagc tggtggagtc tgggggagac ttggtacagt cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttaga aactatgcca tgagttgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaacc actagtggta gtggtggtag cccacactac 180 gcagcctccg tgaagggccg gttcaccatc tccagagaca attccaagaa tacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat atttctgtgc gaaaatagat 300 acagctatgg ccctctacta ctactacgct atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 1434 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1434 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Thr Ser Gly Ser Gly Gly Ser Pro His Tyr Ala Ala Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Lys Ile Asp Thr Ala Met Ala Leu Tyr Tyr Tyr Tyr Ala Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1435 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1435 ggattcacct ttagaaacta tgcc 24 <210> 1436 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1436 Gly Phe Thr Phe Arg Asn Tyr Ala 1 5 <210> 1437 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1437 actagtggta gtggtggtag ccca 24 <210> 1438 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1438 Thr Ser Gly Ser Gly Gly Ser Pro 1 5 <210> 1439 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1439 gcgaaaatag atacagctat ggccctctac tactactacg ctatggacgt c 51 <210> 1440 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1440 Ala Lys Ile Asp Thr Ala Met Ala Leu Tyr Tyr Tyr Tyr Ala Met Asp 1 5 10 15 Val <210> 1441 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1441 gacatcctga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt accctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 1442 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1442 Asp Ile Leu Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1443 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1443 cagggcatta gcagttat 18 <210> 1444 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1444 Gln Gly Ile Ser Ser Tyr 1 5 <210> 1445 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1445 gctgcatcc 9 <210> 1446 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1446 Ala Ala Ser 1 <210> 1447 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1447 caacagctta atagttaccc tctcact 27 <210> 1448 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1448 Gln Gln Leu Asn Ser Tyr Pro Leu Thr 1 5 <210> 1449 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1449 caggtgcagc tggtggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60 acctgcactg tctctggtgc ctccatcagt aattactact ggagctggat ccgacagacc 120 ccagggaagg gactggagtg gattggatat ttccattata gtgggagaac caactacaac 180 ccctccctca agagtcgagt ttctatatca gtggacacgt ccaagaatca gttctccctg 240 aacctgaact ttgtgagcgc cgcagacacg gccgtttatt actgtgcgcg ggactccaag 300 gtcattgcag caatcccaag tgctcactgg tatttcgatc cctggggccg tggcacaatg 360 gtcaccgtct cctca 375 <210> 1450 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1450 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Asn Phe Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr Phe 100 105 110 Asp Pro Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1451 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1451 ggtgcctcca tcagtaatta ctac 24 <210> 1452 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1452 Gly Ala Ser Ile Ser Asn Tyr Tyr 1 5 <210> 1453 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1453 ttccattata gtgggagaac c 21 <210> 1454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1454 Phe His Tyr Ser Gly Arg Thr 1 5 <210> 1455 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1455 gcgcgggact ccaaggtcat tgcagcaatc ccaagtgctc actggtattt cgatccc 57 <210> 1456 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1456 Ala Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr 1 5 10 15 Phe Asp Pro <210> 1457 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1457 gacatccaga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattaga acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaattcct gatctatgct gcatccagtt tgcgaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaggactttg caacttacta ctgtcaccag agttacggta ccccgatcac cttcggccaa 300 gggaccaaac tggagatcaa acga 324 <210> 1458 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1458 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Gly Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 1459 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1459 cagaacatta gaacctat 18 <210> 1460 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1460 Gln Asn Ile Arg Thr Tyr 1 5 <210> 1461 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1461 gctgcatcc 9 <210> 1462 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1462 Ala Ala Ser 1 <210> 1463 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1463 caccagagtt acggtacccc gatcacc 27 <210> 1464 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1464 His Gln Ser Tyr Gly Thr Pro Ile Thr 1 5 <210> 1465 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1465 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caaatacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aaactgaatt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggattac 300 gatttttgga gtgcccaagg ggactactac tattacggtg tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 1466 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1466 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Asp Tyr Asp Phe Trp Ser Ala Gln Gly Asp Tyr Tyr Tyr Tyr 100 105 110 Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1467 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1467 ggtggctcca tcagtaatta ctac 24 <210> 1468 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1468 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 1469 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1469 atctattaca gtgggagcac c 21 <210> 1470 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1470 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 1471 <211> 63 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1471 gcgagagagg attacgattt ttggagtgcc caaggggact actactatta cggtgtggac 60 gtc 63 <210> 1472 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1472 Ala Arg Glu Asp Tyr Asp Phe Trp Ser Ala Gln Gly Asp Tyr Tyr Tyr 1 5 10 15 Tyr Gly Val Asp Val 20 <210> 1473 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1473 gacatcctga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca ggatattagc aactggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcggtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgctcac tttcggcgga 300 gggaccaagg tggaaatcaa acga 324 <210> 1474 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1474 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1475 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1475 caggatatta gcaactgg 18 <210> 1476 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1476 Gln Asp Ile Ser Asn Trp 1 5 <210> 1477 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1477 gatgcatcc 9 <210> 1478 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1478 Asp Ala Ser 1 <210> 1479 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1479 caacaggcta acagtttccc gctcact 27 <210> 1480 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1480 Gln Gln Ala Asn Ser Phe Pro Leu Thr 1 5 <210> 1481 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1481 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtgggaaaaa caattataat 180 ccctccctca agagtcgcgt caccataaaa gtagacacgt ccaagaacca gttgtccctg 240 aacctgagct ctgtcaccgc tgcggacacg gccgtgtatt attgtgcgcg agaggggggg 300 ggactcccta cggggggata ttttgaccag tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1482 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1482 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Lys Asn Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Lys Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Gln Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1483 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1483 ggtggctcca tcagtactta ctac 24 <210> 1484 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1484 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1485 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1485 atctataaga gtgggaaaaa c 21 <210> 1486 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1486 Ile Tyr Lys Ser Gly Lys Asn 1 5 <210> 1487 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1487 gcgcgagagg gggggggact ccctacgggg ggatattttg accag 45 <210> 1488 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1488 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Gln 1 5 10 15 <210> 1489 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1489 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg agttatttaa attggtatca actgaaacca 120 ggaaaagccc ctaatctcct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagtc acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1490 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1490 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser His Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1491 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1491 caaaacatta ggagttat 18 <210> 1492 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1492 Gln Asn Ile Arg Ser Tyr 1 5 <210> 1493 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1493 gctgcatcc 9 <210> 1494 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1494 Ala Ala Ser 1 <210> 1495 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1495 caacagagtt acagtcaccc ttacact 27 <210> 1496 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1496 Gln Gln Ser Tyr Ser His Pro Tyr Thr 1 5 <210> 1497 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1497 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagtcc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aggttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgtgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccacggt caccgtctcc 360 tca 363 <210> 1498 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1498 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1499 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1499 ggtggctcca tcagtactta ctac 24 <210> 1500 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1500 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1501 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1501 atctataaga gtggaagaaa c 21 <210> 1502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1502 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1503 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1503 gtgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1504 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1504 Val Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1505 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1505 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1506 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1506 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1507 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1507 caaaacatta ggaattat 18 <210> 1508 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1508 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1509 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1509 gctacatcc 9 <210> 1510 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1510 Ala Thr Ser 1 <210> 1511 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1511 caacagagtt acagtaaccc ttacact 27 <210> 1512 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1512 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1513 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1513 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaggg ggctggagtg ggtctcaggt attagtggtg gtagtggtag tacatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag ggccgaggac acggccgtat attactgtgc gaggtggcaa 300 cgattagagg actggttcga cccctggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 1514 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1514 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 1515 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1515 ggattcacct ttagcagcta tgcc 24 <210> 1516 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1516 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 1517 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1517 attagtggtg gtagtggtag taca 24 <210> 1518 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1518 Ile Ser Gly Gly Ser Gly Ser Thr 1 5 <210> 1519 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1519 gcgaggtggc aacgattaga ggactggttc gacccc 36 <210> 1520 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1520 Ala Arg Trp Gln Arg Leu Glu Asp Trp Phe Asp Pro 1 5 10 <210> 1521 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1521 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ttgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1522 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1522 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1523 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1523 cagagcatta gcaactat 18 <210> 1524 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1524 Gln Ser Ile Ser Asn Tyr 1 5 <210> 1525 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1525 gctgcatcc 9 <210> 1526 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1526 Ala Ala Ser 1 <210> 1527 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1527 caacagagtt acagtacccc gtacact 27 <210> 1528 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1528 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 1529 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1529 gaggtgcagc tggtggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60 acctgcactg tctctggtgc ctccattagt ggttattatt gcagttggat ccggcagccc 120 ccaggtaagg gactggagtg gattggatat atctattaca gtgggagcag caagtacaac 180 ccctccctcg agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg 240 aggctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatgacggg 300 gactacaatg gtatggacgt ctggggccag gggaccacgg tcaccgtctc ctca 354 <210> 1530 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1530 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Gly Tyr 20 25 30 Tyr Cys Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Ser Lys Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Gly Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 1531 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1531 ggtgcctcca ttagtggtta ttat 24 <210> 1532 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1532 Gly Ala Ser Ile Ser Gly Tyr Tyr 1 5 <210> 1533 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1533 atctattaca gtgggagcag c 21 <210> 1534 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1534 Ile Tyr Tyr Ser Gly Ser Ser 1 5 <210> 1535 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1535 gcgagagatg acggggacta caatggtatg gacgtc 36 <210> 1536 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1536 Ala Arg Asp Asp Gly Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 1537 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1537 gacatcctga tgacccagtc tccactctcc ctgcccgtca cccttggaca ggcggcctcc 60 atctcctgta ggtctagtga aggcctcata tacagtgatg gaaagtccta cttgaattgg 120 tttcaccaga ggccaggcca gcctccaagg cgcctaattt ataaggtttc taaccgggac 180 tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc 240 agcagggtgg aggctgagga tgttggactt tattactgca tgcaaagtac ccactggccg 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 1538 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1538 Asp Ile Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Ala Ala Ser Ile Ser Cys Arg Ser Ser Glu Gly Leu Ile Tyr Ser 20 25 30 Asp Gly Lys Ser Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Pro 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ser 85 90 95 Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 1539 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1539 gaaggcctca tatacagtga tggaaagtcc tac 33 <210> 1540 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1540 Glu Gly Leu Ile Tyr Ser Asp Gly Lys Ser Tyr 1 5 10 <210> 1541 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1541 aaggtttct 9 <210> 1542 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1542 Lys Val Ser 1 <210> 1543 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1543 atgcaaagta cccactggcc gctcact 27 <210> 1544 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1544 Met Gln Ser Thr His Trp Pro Leu Thr 1 5 <210> 1545 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1545 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acccatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtagta gtggtggtag cacatactac 180 gcagtacccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgt ggaaggcaac 300 agctggtact actttgagta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 1546 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1546 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr His 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Val Pro Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Glu Gly Asn Ser Trp Tyr Tyr Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 1547 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1547 ggattcacct ttagcaccca tgcc 24 <210> 1548 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1548 Gly Phe Thr Phe Ser Thr His Ala 1 5 <210> 1549 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1549 attagtagta gtggtggtag caca 24 <210> 1550 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1550 Ile Ser Ser Ser Gly Gly Ser Thr 1 5 <210> 1551 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1551 gtggaaggca acagctggta ctactttgag tac 33 <210> 1552 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1552 Val Glu Gly Asn Ser Trp Tyr Tyr Phe Glu Tyr 1 5 10 <210> 1553 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1553 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaactact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccgtcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggtg gctcaccgat caccttcggc 300 caagggacac gactggagat taaacga 327 <210> 1554 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1554 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 1555 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1555 cagagtgtta gcagcaacta c 21 <210> 1556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1556 Gln Ser Val Ser Ser Asn Tyr 1 5 <210> 1557 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1557 ggtacatcc 9 <210> 1558 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1558 Gly Thr Ser 1 <210> 1559 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1559 cagcagtatg gtggctcacc gatcacc 27 <210> 1560 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1560 Gln Gln Tyr Gly Gly Ser Pro Ile Thr 1 5 <210> 1561 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1561 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattggatat atctataaga gtggaagaaa cttcaataat 180 ccctccctca agagtcgagt caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccaa cggggggata ctatgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1562 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1562 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Asn Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Tyr Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1563 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1563 ggtggctcca tcagtactta ctac 24 <210> 1564 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1564 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1565 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1565 atctataaga gtggaagaaa c 21 <210> 1566 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1566 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1567 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1567 gcgagagagg gggggggact cccaacgggg ggatactatg actcc 45 <210> 1568 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1568 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Tyr Asp Ser 1 5 10 15 <210> 1569 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1569 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1570 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1570 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1571 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1571 caaaacatta ggaattat 18 <210> 1572 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1572 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1573 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1573 gctacatcc 9 <210> 1574 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1574 Ala Thr Ser 1 <210> 1575 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1575 caacagagtt acagtaaccc ttacact 27 <210> 1576 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1576 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1577 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1577 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattggatat atctataaga gtggaagaaa cttcaataat 180 ccctccctca agagtcgagt caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccaa cggggggata ctatgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1578 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1578 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Asn Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Tyr Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1579 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1579 ggtggctcca tcagtactta ctac 24 <210> 1580 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1580 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1581 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1581 atctataaga gtggaagaaa c 21 <210> 1582 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1582 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1583 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1583 gcgagagagg gggggggact cccaacgggg ggatactatg actcc 45 <210> 1584 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1584 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Tyr Asp Ser 1 5 10 15 <210> 1585 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1585 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1586 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1586 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1587 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1587 caaaacatta ggaattat 18 <210> 1588 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1588 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1589 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1589 gctacatcc 9 <210> 1590 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1590 Ala Thr Ser 1 <210> 1591 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1591 caacagagtt acagtaaccc ttacact 27 <210> 1592 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1592 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1593 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1593 caggtgcagc tggtggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aatgactact ggagctggat ccgacagacc 120 ccagggaagg gactggagtg gattggatat ttccattata gtgggagaac caactacaac 180 ccctccctca agagtcgagt ttctatatca gtggacacgt ccaagaatca gttctccctg 240 aacctgagct ttgtgagcgc cgcagacacg gccgtttatt actgtgcgcg ggactccaag 300 gtcattgcag caatcccaag tgctcactgg tatttcgatc cctggggccg tggcacactg 360 gtcaccgtct cctca 375 <210> 1594 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1594 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Asp 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Ser Phe Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr Phe 100 105 110 Asp Pro Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1595 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1595 ggtggctcca tcagtaatga ctac 24 <210> 1596 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1596 Gly Gly Ser Ile Ser Asn Asp Tyr 1 5 <210> 1597 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1597 ttccattata gtgggagaac c 21 <210> 1598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1598 Phe His Tyr Ser Gly Arg Thr 1 5 <210> 1599 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1599 gcgcgggact ccaaggtcat tgcagcaatc ccaagtgctc actggtattt cgatccc 57 <210> 1600 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1600 Ala Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr 1 5 10 15 Phe Asp Pro <210> 1601 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1601 gacatcctga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattaga acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcgaagtga ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaggactttg caacttacta ctgtcaccag agttacggta ccccgatcac cttcggccaa 300 gggaccaaac tggagatcaa acga 324 <210> 1602 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1602 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Arg Ser Glu Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Gly Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 1603 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1603 cagaacatta gaacctat 18 <210> 1604 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1604 Gln Asn Ile Arg Thr Tyr 1 5 <210> 1605 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1605 gctgcatcc 9 <210> 1606 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1606 Ala Ala Ser 1 <210> 1607 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1607 caccagagtt acggtacccc gatcacc 27 <210> 1608 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1608 His Gln Ser Tyr Gly Thr Pro Ile Thr 1 5 <210> 1609 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1609 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt catcatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1610 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1610 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1611 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1611 ggtggctcca tcagtactta ctac 24 <210> 1612 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1612 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1613 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1613 atctataaga gtggaagaaa c 21 <210> 1614 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1614 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1615 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1615 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1616 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1616 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1617 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1617 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaaatgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1618 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1618 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1619 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1619 caaaacatta ggaattat 18 <210> 1620 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1620 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1621 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1621 gctacatcc 9 <210> 1622 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1622 Ala Thr Ser 1 <210> 1623 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1623 caacagagtt acagtaaccc ttacact 27 <210> 1624 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1624 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1625 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1625 gaggtgcagc tggtggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60 acctgcactg tctctggtgc ctccatcagt aattactact ggagctggat ccgacagacc 120 ccagggaagg gactggagtg gattggatat ttccattata gtgggagaac caactacaac 180 ccctccctca agagtcgagt ttctatatca gtggacacgt ccaagaatca gttctccctg 240 aacctgaact ttgtgagcgc cgcagacacg gccgtttatt actgtgcgcg ggactccaag 300 gtcattgcag caatcccaag tgctcactgg tatttcgatc cctggggccg tggcacaatg 360 gtcaccgtct cctca 375 <210> 1626 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1626 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Asn Phe Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr Phe 100 105 110 Asp Pro Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1627 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1627 ggtgcctcca tcagtaatta ctac 24 <210> 1628 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1628 Gly Ala Ser Ile Ser Asn Tyr Tyr 1 5 <210> 1629 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1629 ttccattata gtgggagaac c 21 <210> 1630 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1630 Phe His Tyr Ser Gly Arg Thr 1 5 <210> 1631 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1631 gcgcgggact ccaaggtcat tgcagcaatc ccaagtgctc actggtattt cgatccc 57 <210> 1632 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1632 Ala Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr 1 5 10 15 Phe Asp Pro <210> 1633 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1633 gacatccaga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattaga acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaattcct gatctatgct gcatccagtt tgcgaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaggactttg caacttacta ctgtcaccag agttacggta ccccgatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 1634 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1634 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Gly Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 1635 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1635 cagaacatta gaacctat 18 <210> 1636 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1636 Gln Asn Ile Arg Thr Tyr 1 5 <210> 1637 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1637 gctgcatcc 9 <210> 1638 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1638 Ala Ala Ser 1 <210> 1639 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1639 caccagagtt acggtacccc gatcacc 27 <210> 1640 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1640 His Gln Ser Tyr Gly Thr Pro Ile Thr 1 5 <210> 1641 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1641 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtgggaaaaa caattataat 180 ccctccctca agagtcgcgt caccataaaa gtagacacgt ccaagaacca gttgtccctg 240 aacctgagtt ctgtgaccgc tgcggacacg gccgtatatt attgtgcgag agaggggggg 300 ggactcccta cggggggata ttttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1642 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1642 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Lys Asn Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Lys Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1643 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1643 ggtggctcca tcagtactta ctac 24 <210> 1644 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1644 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1645 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1645 atctataaga gtgggaaaaa c 21 <210> 1646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1646 Ile Tyr Lys Ser Gly Lys Asn 1 5 <210> 1647 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1647 gcgagagagg gggggggact ccctacgggg ggatattttg actac 45 <210> 1648 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1648 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr 1 5 10 15 <210> 1649 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1649 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg agttatttaa attggtatca actgaaacca 120 ggaaaagccc ctaatctcct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacaggt ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagtc acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1650 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1650 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser His Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1651 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1651 caaaacatta ggagttat 18 <210> 1652 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1652 Gln Asn Ile Arg Ser Tyr 1 5 <210> 1653 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1653 gctgcatcc 9 <210> 1654 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1654 Ala Ala Ser 1 <210> 1655 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1655 caacagagtt acagtcaccc ttacact 27 <210> 1656 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1656 Gln Gln Ser Tyr Ser His Pro Tyr Thr 1 5 <210> 1657 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1657 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggcgac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agtcactatt ggagctggat ccgtcagtcc 120 ccaggggagg gactggaatg gattggatat atcctttcca gtgggaggac caactacaag 180 tcctccctca ggagccgagt caccatgtca gtagacacgt ccaagaacca gttattcctg 240 gagctgacct ctgtgaccgc tgcggacacg gccgtatatt tctgtgcgag agaggagggg 300 ggactcccca ctgggggcta ctttgacaac tggggccagg gaatcctggt caccgtctcc 360 tca 363 <210> 1658 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1658 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Ala 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser His 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Glu Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Leu Ser Ser Gly Arg Thr Asn Tyr Lys Ser Ser Leu Arg 50 55 60 Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Leu Phe Leu 65 70 75 80 Glu Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Glu Glu Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Asn Trp Gly 100 105 110 Gln Gly Ile Leu Val Thr Val Ser Ser 115 120 <210> 1659 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1659 ggtggctcca tcagtagtca ctat 24 <210> 1660 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1660 Gly Gly Ser Ile Ser Ser His Tyr 1 5 <210> 1661 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1661 atcctttcca gtgggaggac c 21 <210> 1662 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1662 Ile Leu Ser Ser Gly Arg Thr 1 5 <210> 1663 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1663 gcgagagagg aggggggact ccccactggg ggctactttg acaac 45 <210> 1664 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1664 Ala Arg Glu Glu Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Asn 1 5 10 15 <210> 1665 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1665 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcact 60 atcacttgcc gggcaagtca gaacatttat agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctcatctcct gatctatgct gcatccagtt tgcaaagtgg agtcccttca 180 aggttcagtg gcagtggatc tgacacagat ttcactctca ccatcaccag tctgcagcct 240 gaagattttg caacttactt ctgtcaacag aattacaata tgccttacag ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1666 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1666 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro His Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Asp Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Asn Tyr Asn Met Pro Tyr 85 90 95 Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1667 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1667 cagaacattt atagttat 18 <210> 1668 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1668 Gln Asn Ile Tyr Ser Tyr 1 5 <210> 1669 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1669 gctgcatcc 9 <210> 1670 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1670 Ala Ala Ser 1 <210> 1671 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1671 caacagaatt acaatatgcc ttacagt 27 <210> 1672 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1672 Gln Gln Asn Tyr Asn Met Pro Tyr Ser 1 5 <210> 1673 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1673 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt cagcataaca atagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1674 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1674 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Thr Ile Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1675 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1675 ggtggctcca tcagtactta ctac 24 <210> 1676 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1676 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1677 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1677 atctataaga gtggaagaaa c 21 <210> 1678 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1678 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1679 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1679 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1680 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1680 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1681 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1681 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg atttatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1682 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1682 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Ile Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1683 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1683 caaaacatta ggatttat 18 <210> 1684 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1684 Gln Asn Ile Arg Ile Tyr 1 5 <210> 1685 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1685 gctacatcc 9 <210> 1686 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1686 Ala Thr Ser 1 <210> 1687 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1687 caacagagtt acagtaaccc ttacact 27 <210> 1688 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1688 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1689 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1689 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattggttat atctataaga gtggaagaaa cttctataat 180 ccctccctca tgagtcgagt caccataaca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaatcctggt caccgtctcc 360 tca 363 <210> 1690 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1690 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Met 50 55 60 Ser Arg Val Thr Ile Thr Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Ile Leu Val Thr Val Ser Ser 115 120 <210> 1691 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1691 ggtggctcca tcagtactta ctac 24 <210> 1692 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1692 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1693 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1693 atctataaga gtggaagaaa c 21 <210> 1694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1694 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1695 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1695 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1696 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1696 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1697 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1697 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tcttcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1698 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1698 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1699 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1699 caaaacatta ggaattat 18 <210> 1700 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1700 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1701 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1701 gctacatcc 9 <210> 1702 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1702 Ala Thr Ser 1 <210> 1703 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1703 caacagagtt acagtaaccc ttacact 27 <210> 1704 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1704 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1705 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1705 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt catcatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1706 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1706 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1707 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1707 ggtggctcca tcagtactta ctac 24 <210> 1708 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1708 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1709 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1709 atctataaga gtggaagaaa c 21 <210> 1710 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1710 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1711 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1711 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1712 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1712 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1713 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1713 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaaatgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1714 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1714 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1715 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1715 caaaacatta ggaattat 18 <210> 1716 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1716 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1717 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1717 gctacatcc 9 <210> 1718 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1718 Ala Thr Ser 1 <210> 1719 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1719 caacagagtt acagtaaccc ttacact 27 <210> 1720 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1720 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1721 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1721 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agtcactact ggagctggat ccggcagccc 120 ccagggaagg gactggaatg gattgggtat atcttttcca gtgggaggac caactacaag 180 tcctccctca ggagtcgagt caccatgtca gtagacacgt ccaagaacca gttatccctg 240 aagctgacct ctgtgaccgc tgcggacacg gccgtatatt actgtgcgag agaggggggg 300 ggactcccta ctgggggcta ctttgactac tggggccagg gaaccacggt caccgtctcc 360 tca 363 <210> 1722 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1722 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser His 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Phe Ser Ser Gly Arg Thr Asn Tyr Lys Ser Ser Leu Arg 50 55 60 Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1723 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1723 ggtggctcca tcagtagtca ctac 24 <210> 1724 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1724 Gly Gly Ser Ile Ser Ser His Tyr 1 5 <210> 1725 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1725 atcttttcca gtgggaggac c 21 <210> 1726 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1726 Ile Phe Ser Ser Gly Arg Thr 1 5 <210> 1727 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1727 gcgagagagg gggggggact ccctactggg ggctactttg actac 45 <210> 1728 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1728 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr 1 5 10 15 <210> 1729 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1729 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcact 60 atcacttgcc gggcaagtca gaacatttat agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaatctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccttca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcagcct 240 gaagattttg caacttactt ctgtcaacag aattacaata tgccttacag ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1730 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1730 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Asn Tyr Asn Met Pro Tyr 85 90 95 Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1731 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1731 cagaacattt atagttat 18 <210> 1732 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1732 Gln Asn Ile Tyr Ser Tyr 1 5 <210> 1733 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1733 gctgcatcc 9 <210> 1734 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1734 Ala Ala Ser 1 <210> 1735 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1735 caacagaatt acaatatgcc ttacagt 27 <210> 1736 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1736 Gln Gln Asn Tyr Asn Met Pro Tyr Ser 1 5 <210> 1737 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1737 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagc acttattatt ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccacggt caccgtctcc 360 tca 363 <210> 1738 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1738 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1739 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1739 ggtggctcca tcagcactta ttat 24 <210> 1740 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1740 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1741 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1741 atctataaga gtggaagaaa c 21 <210> 1742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1742 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1743 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1743 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1744 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1744 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1745 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1745 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtga ggtcccatca 180 agattcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1746 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1746 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Glu Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1747 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1747 caaaacatta ggaattat 18 <210> 1748 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1748 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1749 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1749 gctacatcc 9 <210> 1750 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1750 Ala Thr Ser 1 <210> 1751 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1751 caacagagtt acagtaaccc ttacact 27 <210> 1752 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1752 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1753 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1753 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcaggcc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa gttctataat 180 ccctccctca agagtcgagg caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1754 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1754 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Lys Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Gly Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1755 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1755 ggtggctcca tcagtactta ctac 24 <210> 1756 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1756 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1757 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1757 atctataaga gtggaagaaa g 21 <210> 1758 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1758 Ile Tyr Lys Ser Gly Arg Lys 1 5 <210> 1759 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1759 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1760 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1760 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1761 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1761 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 agattcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactg ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1762 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1762 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1763 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1763 caaaacatta ggaattat 18 <210> 1764 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1764 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1765 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1765 gctacatcc 9 <210> 1766 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1766 Ala Thr Ser 1 <210> 1767 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1767 caacagagtt acagtaaccc ttacact 27 <210> 1768 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1768 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1769 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1769 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgt ctccatcagt agtcactact ggaactggat ccggcagccc 120 ccaggggagg gcctggaatg gattggatat atcttctcta ctaggaggac caactacaag 180 tcctccctca ggagtcgagt caccatgtca gtagacacgt ccaagaacca gttatccctg 240 aagctgacct ctgtgaccgc tgcggacacg gccgtatatt actgtgcgag agaggagggg 300 ggactcccta ctgggggcta ttttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1770 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1770 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Ser Ser His 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Glu Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Phe Ser Thr Arg Arg Thr Asn Tyr Lys Ser Ser Leu Arg 50 55 60 Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Glu Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1771 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1771 ggtgtctcca tcagtagtca ctac 24 <210> 1772 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1772 Gly Val Ser Ile Ser Ser His Tyr 1 5 <210> 1773 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1773 atcttctcta ctaggaggac c 21 <210> 1774 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1774 Ile Phe Ser Thr Arg Arg Thr 1 5 <210> 1775 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1775 gcgagagagg aggggggact ccctactggg ggctattttg actac 45 <210> 1776 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1776 Ala Arg Glu Glu Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr 1 5 10 15 <210> 1777 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1777 gacatccaga tgacccagtc tccatcctcc ctgtctgcgt ctgtaggaga cagagtcact 60 atcacttgcc ggccaagtca gaacatttat agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaatctcct gatctatact gcatccagtt tgcaaagcgg ggtctcttca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcagcct 240 gaagattttg caacttactt ctgtcaacag aattacaata tgccttacag ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1778 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1778 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Asn Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Asn Tyr Asn Met Pro Tyr 85 90 95 Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1779 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1779 cagaacattt atagttat 18 <210> 1780 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1780 Gln Asn Ile Tyr Ser Tyr 1 5 <210> 1781 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1781 actgcatcc 9 <210> 1782 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1782 Thr Ala Ser 1 <210> 1783 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1783 caacagaatt acaatatgcc ttacagt 27 <210> 1784 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1784 Gln Gln Asn Tyr Asn Met Pro Tyr Ser 1 5 <210> 1785 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1785 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgt 120 cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gaacacctac 180 tacaacccgt ccctcaagag tcgagttacc atatcaatag acacgtctaa gaaccagttc 240 tccctgaagc tgaactctgt gactgccgcg gacacggccg tctattactg tgcgcgagga 300 gttataggaa ctatgattat agcagcagct atcccttttg actactgggg ccagggaacc 360 atggtcaccg tctcctca 378 <210> 1786 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1786 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Val Ile Gly Thr Met Ile Ile Ala Ala Ala Ile Pro 100 105 110 Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1787 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1787 ggtggctcca tcagcagtgg tggttactac 30 <210> 1788 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1788 Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr 1 5 10 <210> 1789 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1789 atctattaca gtgggaacac c 21 <210> 1790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1790 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 1791 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1791 gcgcgaggag ttataggaac tatgattata gcagcagcta tcccttttga ctac 54 <210> 1792 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1792 Ala Arg Gly Val Ile Gly Thr Met Ile Ile Ala Ala Ala Ile Pro Phe 1 5 10 15 Asp Tyr <210> 1793 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1793 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcagcct 240 gcagattttg caacttactc ctgtcagcag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1794 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1794 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Ala Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1795 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1795 caaaacatta ggaattat 18 <210> 1796 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1796 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1797 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1797 gctacatcc 9 <210> 1798 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1798 Ala Thr Ser 1 <210> 1799 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1799 cagcagagtt acagtaaccc ttacact 27 <210> 1800 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1800 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1801 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1801 caggtgcagc tggtggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60 acctgcactg tctctggtgc ctccatcagt aattactact ggagctggat ccgacagacc 120 ccagggaagg gactggagtg gattggatat ttccattata gtgggagaac caactacaac 180 ccctccctca agagtcgagt ttctatatca gtggacacgt ccaagaatca gttctccctg 240 aacctgaact ttgtgagcgc cgcagacacg gccgtttatt actgtgcgcg ggactccaag 300 gtcattgcag caatcccaag tgctcactgg tatttcgatc cctggggccg tggcacactg 360 gtcaccgtct cctca 375 <210> 1802 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1802 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Asn Phe Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr Phe 100 105 110 Asp Pro Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1803 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1803 ggtgcctcca tcagtaatta ctac 24 <210> 1804 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1804 Gly Ala Ser Ile Ser Asn Tyr Tyr 1 5 <210> 1805 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1805 ttccattata gtgggagaac c 21 <210> 1806 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1806 Phe His Tyr Ser Gly Arg Thr 1 5 <210> 1807 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1807 gcgcgggact ccaaggtcat tgcagcaatc ccaagtgctc actggtattt cgatccc 57 <210> 1808 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1808 Ala Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr 1 5 10 15 Phe Asp Pro <210> 1809 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1809 gacatccaga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattaga acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaattcct gatctatgct gcatccagtt tgcgaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaggactttg caacttacta ctgtcaccag agttacggta ccccgatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 1810 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1810 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Gly Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 1811 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1811 cagaacatta gaacctat 18 <210> 1812 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1812 Gln Asn Ile Arg Thr Tyr 1 5 <210> 1813 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1813 gctgcatcc 9 <210> 1814 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1814 Ala Ala Ser 1 <210> 1815 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1815 caccagagtt acggtacccc gatcacc 27 <210> 1816 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1816 His Gln Ser Tyr Gly Thr Pro Ile Thr 1 5 <210> 1817 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1817 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agtcactatt ggagctggat ccgtcagccc 120 ccaggggagg gactggaatg gattggatat atcctttcca gtgggaggac caactacaag 180 tcctccctca ggacccgagt caccatgtca gtagacacgt ccaagaacca gttattcctg 240 gagctgacct ctgtgaccgc tgcggacacg gccgtatatt tctgtgcgag agaggagggg 300 ggactcccca ctgggggcta ctttgacaac tggggccagg gaatcctggt caccgtctcc 360 tca 363 <210> 1818 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1818 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser His 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Glu Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Leu Ser Ser Gly Arg Thr Asn Tyr Lys Ser Ser Leu Arg 50 55 60 Thr Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Leu Phe Leu 65 70 75 80 Glu Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Glu Glu Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Asn Trp Gly 100 105 110 Gln Gly Ile Leu Val Thr Val Ser Ser 115 120 <210> 1819 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1819 ggtggctcca tcagtagtca ctat 24 <210> 1820 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1820 Gly Gly Ser Ile Ser Ser His Tyr 1 5 <210> 1821 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1821 atcctttcca gtgggaggac c 21 <210> 1822 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1822 Ile Leu Ser Ser Gly Arg Thr 1 5 <210> 1823 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1823 gcgagagagg aggggggact ccccactggg ggctactttg acaac 45 <210> 1824 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1824 Ala Arg Glu Glu Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Asn 1 5 10 15 <210> 1825 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1825 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcact 60 atcacttgcc gggcaagtca gaacatttat agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctcatctcct gatctatgct gcatccagtt tgcaaagtgg agtcccttca 180 aggttcagtg gcagtggatc tgacacagat ttcactctca ccatcaccag tctgcagcct 240 gaagattttg ctacttactt ctgtcaacag aattacaata tgccttacag ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1826 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1826 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro His Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Asp Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Asn Tyr Asn Met Pro Tyr 85 90 95 Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1827 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1827 cagaacattt atagttat 18 <210> 1828 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1828 Gln Asn Ile Tyr Ser Tyr 1 5 <210> 1829 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1829 gctgcatcc 9 <210> 1830 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1830 Ala Ala Ser 1 <210> 1831 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1831 caacagaatt acaatatgcc ttacagt 27 <210> 1832 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1832 Gln Gln Asn Tyr Asn Met Pro Tyr Ser 1 5 <210> 1833 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1833 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gaggaccggg 300 tatagcagca gccgtccatt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 1834 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1834 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Tyr Ser Ser Ser Arg Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1835 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1835 ggattcacct tcagtagtta tgaa 24 <210> 1836 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1836 Gly Phe Thr Phe Ser Ser Tyr Glu 1 5 <210> 1837 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1837 attagtagta gtggtagtac cata 24 <210> 1838 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1838 Ile Ser Ser Ser Gly Ser Thr Ile 1 5 <210> 1839 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1839 gcgaggaccg ggtatagcag cagccgtcca tttgactac 39 <210> 1840 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1840 Ala Arg Thr Gly Tyr Ser Ser Ser Arg Pro Phe Asp Tyr 1 5 10 <210> 1841 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1841 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag tatgataatc tccctccgct cactttcggc 300 ggagggacca aggtggagat caaacga 327 <210> 1842 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1842 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1843 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1843 caggacatta gcaactat 18 <210> 1844 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1844 Gln Asp Ile Ser Asn Tyr 1 5 <210> 1845 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1845 gctacatcc 9 <210> 1846 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1846 Ala Thr Ser 1 <210> 1847 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1847 caacagtatg ataatctccc tccgctcact 30 <210> 1848 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1848 Gln Gln Tyr Asp Asn Leu Pro Pro Leu Thr 1 5 10 <210> 1849 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1849 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tcgctggtgg ctccatcagt acttactact ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt attgtgtgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1850 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1850 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ala Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1851 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1851 ggtggctcca tcagtactta ctac 24 <210> 1852 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1852 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1853 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1853 atctataaga gtggaagaaa c 21 <210> 1854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1854 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1855 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1855 gtgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1856 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1856 Val Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1857 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1857 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1858 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1858 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1859 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1859 caaaacatta ggaattat 18 <210> 1860 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1860 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1861 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1861 gctacatcc 9 <210> 1862 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1862 Ala Thr Ser 1 <210> 1863 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1863 caacagagtt acagtaaccc ttacact 27 <210> 1864 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1864 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1865 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1865 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcagtcc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtgggaaaaa caattataat 180 ccctccctca agagtcgcgt caccataaaa gtagacacgt ccaagaacca gttgtccctg 240 aacctgaggt ctgtgaccgc tgcggacacg gccgtgtatt attgtgcgag agaggggggg 300 ggactcccta cggggggata ttttgactac tggggccagg gaaccccggt caccgtctcc 360 tca 363 <210> 1866 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1866 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Lys Asn Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Lys Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Pro Val Thr Val Ser Ser 115 120 <210> 1867 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1867 ggtggctcca tcagtactta ctac 24 <210> 1868 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1868 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1869 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1869 atctataaga gtgggaaaaa c 21 <210> 1870 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1870 Ile Tyr Lys Ser Gly Lys Asn 1 5 <210> 1871 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1871 gcgagagagg gggggggact ccctacgggg ggatattttg actac 45 <210> 1872 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1872 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Tyr 1 5 10 15 <210> 1873 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1873 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg agttatttaa attggtatca actgaaacca 120 ggaaaagccc ctaatctcct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagtc acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1874 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1874 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser His Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1875 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1875 caaaacatta ggagttat 18 <210> 1876 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1876 Gln Asn Ile Arg Ser Tyr 1 5 <210> 1877 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1877 gctgcatcc 9 <210> 1878 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1878 Ala Ala Ser 1 <210> 1879 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1879 caacagagtt acagtcaccc ttacact 27 <210> 1880 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1880 Gln Gln Ser Tyr Ser His Pro Tyr Thr 1 5 <210> 1881 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1881 gaggtgcagc tggtggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60 acctgcactg tctctggtgc ctccatcagt aattactact ggagctggat ccgacagacc 120 ccagggaagg gactggagtg gattggatat ttccattata gtgggagaac caactacaac 180 ccctccctca agagtcgagt ttctatatca gtggacacgt ccaagaatca gttctccctg 240 aacctgaact ttgtgagcgc cgcagacacg gccgtttatt actgtgcgcg ggactccaag 300 gtcattgcag caatcccaag tgctcactgg tatttcgatc cctggggccg tggcacactg 360 gtcaccgtct cctca 375 <210> 1882 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1882 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Phe His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Asn Phe Val Ser Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr Phe 100 105 110 Asp Pro Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1883 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1883 ggtgcctcca tcagtaatta ctac 24 <210> 1884 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1884 Gly Ala Ser Ile Ser Asn Tyr Tyr 1 5 <210> 1885 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1885 ttccattata gtgggagaac c 21 <210> 1886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1886 Phe His Tyr Ser Gly Arg Thr 1 5 <210> 1887 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1887 gcgcgggact ccaaggtcat tgcagcaatc ccaagtgctc actggtattt cgatccc 57 <210> 1888 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1888 Ala Arg Asp Ser Lys Val Ile Ala Ala Ile Pro Ser Ala His Trp Tyr 1 5 10 15 Phe Asp Pro <210> 1889 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1889 gacatccaga tgacccagtc tccatcctcc ctgtctgcct ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattaga acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaattcct gatctatgct gcatccagtt tgcgaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaggactttg caacttacta ctgtcaccag agttacggta ccccgatcac cttcggccaa 300 gggaccaaac tggagatcaa acga 324 <210> 1890 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1890 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Gly Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 1891 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1891 cagaacatta gaacctat 18 <210> 1892 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1892 Gln Asn Ile Arg Thr Tyr 1 5 <210> 1893 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1893 gctgcatcc 9 <210> 1894 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1894 Ala Ala Ser 1 <210> 1895 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1895 caccagagtt acggtacccc gatcacc 27 <210> 1896 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1896 His Gln Ser Tyr Gly Thr Pro Ile Thr 1 5 <210> 1897 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1897 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaattggat ccggcaggcc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa gttctataat 180 ccctccctca agagtcgagg caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1898 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1898 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Lys Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Gly Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1899 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1899 ggtggctcca tcagtactta ctac 24 <210> 1900 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1900 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1901 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1901 atctataaga gtggaagaaa g 21 <210> 1902 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1902 Ile Tyr Lys Ser Gly Arg Lys 1 5 <210> 1903 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1903 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1904 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1904 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1905 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1905 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtgg ggtcccatca 180 agattcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactg ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1906 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1906 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1907 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1907 caaaacatta ggaattat 18 <210> 1908 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1908 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1909 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1909 gctacatcc 9 <210> 1910 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1910 Ala Thr Ser 1 <210> 1911 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1911 caacagagtt acagtaaccc ttacact 27 <210> 1912 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1912 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1913 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1913 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagc acttattatt ggaattggat ccggcagccc 120 ccagggaagg gactggaatt gattgggtat atctataaga gtggaagaaa cttctataat 180 ccctccctca agagtcgagt caccatagca gtagacacgt ccacgaacca gttgtcgctg 240 aagttgacct cagtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaggggggg 300 ggactcccta cggggggata ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 1914 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1914 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 35 40 45 Gly Tyr Ile Tyr Lys Ser Gly Arg Asn Phe Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ala Val Asp Thr Ser Thr Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 1915 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1915 ggtggctcca tcagcactta ttat 24 <210> 1916 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1916 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 1917 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1917 atctataaga gtggaagaaa c 21 <210> 1918 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1918 Ile Tyr Lys Ser Gly Arg Asn 1 5 <210> 1919 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1919 gcgagagagg gggggggact ccctacgggg ggatactttg actcc 45 <210> 1920 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1920 Ala Arg Glu Gly Gly Gly Leu Pro Thr Gly Gly Tyr Phe Asp Ser 1 5 10 15 <210> 1921 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1921 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaacattagg aattatttaa attggtatca actgaaacca 120 gggaaagccc ctaacctcct gatctatgct acatccaatt tgcaaagtga ggtcccatca 180 agattcagtg gcagtggatc tgggacagat ttcactctct ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtcaacag agttacagta acccttacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1922 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1922 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Asn Leu Gln Ser Glu Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Asn Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1923 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1923 caaaacatta ggaattat 18 <210> 1924 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1924 Gln Asn Ile Arg Asn Tyr 1 5 <210> 1925 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1925 gctacatcc 9 <210> 1926 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1926 Ala Thr Ser 1 <210> 1927 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1927 caacagagtt acagtaaccc ttacact 27 <210> 1928 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1928 Gln Gln Ser Tyr Ser Asn Pro Tyr Thr 1 5 <210> 1929 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1929 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tcaacggtgg gtccttcaat tattaccact ggacctggat ccgccagccc 120 ccagggaagg ggctggaatg gattggggaa atcaatcata ctggaagcac caactataat 180 ccgtccctca agagtcgagt caccatatca gttgacacgt ccaagaacca gttctccctg 240 aggctgaggt ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggccctact 300 tcggtgacta cggactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 1930 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1930 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Asn Gly Gly Ser Phe Asn Tyr Tyr 20 25 30 His Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Thr Ser Val Thr Thr Asp Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 1931 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1931 ggtgggtcct tcaattatta ccac 24 <210> 1932 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1932 Gly Gly Ser Phe Asn Tyr Tyr His 1 5 <210> 1933 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1933 atcaatcata ctggaagcac c 21 <210> 1934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1934 Ile Asn His Thr Gly Ser Thr 1 5 <210> 1935 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1935 gcgagaggcc ctacttcggt gactacggac tactacggta tggacgtc 48 <210> 1936 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1936 Ala Arg Gly Pro Thr Ser Val Thr Thr Asp Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 1937 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1937 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagt agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat gatgcgtcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcaa cagactggag 240 cctgaagatt ttgcagtata ttactgtcag cagtttggtc cctcaccgtt cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 1938 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1938 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Pro Ser Pro 85 90 95 Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1939 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1939 cagagtgtta gtagcagcta c 21 <210> 1940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1940 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 1941 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1941 gatgcgtcc 9 <210> 1942 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1942 Asp Ala Ser 1 <210> 1943 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1943 cagcagtttg gtccctcacc gttcact 27 <210> 1944 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1944 Gln Gln Phe Gly Pro Ser Pro Phe Thr 1 5 <210> 1945 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1945 gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccagtct 120 ccagggaagg ggctggagtg ggtttcacac attagtggta gtggtaaaat catatatcac 180 gcagactatg tgaagggccg attcaccatc tccagggaca acgccaagaa gtcattgtat 240 ctgctaatga acagcctgag agccgaagac acggccgtgt attactgtgc gagagaggag 300 gtttactatg ggtcggggag ttttgagtac tggggccagg gaaccatggt caccgtctcc 360 tca 363 <210> 1946 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1946 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Tyr Met Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Gly Ser Gly Lys Ile Ile Tyr His Ala Asp Tyr Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Val Tyr Tyr Gly Ser Gly Ser Phe Glu Tyr Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 1947 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1947 ggattcacct tcagtgacta ctac 24 <210> 1948 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1948 Gly Phe Thr Phe Ser Asp Tyr Tyr 1 5 <210> 1949 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1949 attagtggta gtggtaaaat cata 24 <210> 1950 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1950 Ile Ser Gly Ser Gly Lys Ile Ile 1 5 <210> 1951 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1951 gcgagagagg aggtttacta tgggtcgggg agttttgagt ac 42 <210> 1952 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1952 Ala Arg Glu Glu Val Tyr Tyr Gly Ser Gly Ser Phe Glu Tyr 1 5 10 <210> 1953 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1953 gacatcgtga tgacccagtc tccagacttt cagtctgtga ctccaaagga gagagtcacc 60 atcacctgcc gggccagtca gaccattggt agcagcttac actggtacca gcagaaacca 120 gatcagtctc caaagctcct catcaagtat gcttcccagt ccttctcagg ggtcccctcg 180 aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatgg cctggaagct 240 gaagatgctg caacgtatta ctgtcatcag agtagtagtt taccgtggac gttcggccaa 300 gggaccaagg tggaaatcaa acga 324 <210> 1954 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1954 Asp Ile Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Ser Ser 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Glu Ala 65 70 75 80 Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1955 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1955 cagaccattg gtagcagc 18 <210> 1956 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1956 Gln Thr Ile Gly Ser Ser 1 5 <210> 1957 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1957 tatgcttcc 9 <210> 1958 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1958 Tyr Ala Ser 1 <210> 1959 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1959 catcagagta gtagtttacc gtggacg 27 <210> 1960 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1960 His Gln Ser Ser Ser Leu Pro Trp Thr 1 5 <210> 1961 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1961 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg gatttcatac attagtacta gtggtagtac catatactac 180 gctgactctg tgaagggccg attcaccatc tccagagacg acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc ggtgggatat 300 gggtggctac gattgtgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 1962 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1962 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ser Tyr Ile Ser Thr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Val Gly Tyr Gly Trp Leu Arg Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 1963 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1963 ggattcacct tcagtagtta tgaa 24 <210> 1964 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1964 Gly Phe Thr Phe Ser Ser Tyr Glu 1 5 <210> 1965 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1965 attagtacta gtggtagtac cata 24 <210> 1966 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1966 Ile Ser Thr Ser Gly Ser Thr Ile 1 5 <210> 1967 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1967 gcggtgggat atgggtggct acgattg 27 <210> 1968 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1968 Ala Val Gly Tyr Gly Trp Leu Arg Leu 1 5 <210> 1969 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1969 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattagc atttatttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaaag tatagcagtg ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 1970 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1970 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ile Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Ser Ser Ala Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1971 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1971 cagggcatta gcatttat 18 <210> 1972 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1972 Gln Gly Ile Ser Ile Tyr 1 5 <210> 1973 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1973 gctgcatcc 9 <210> 1974 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1974 Ala Ala Ser 1 <210> 1975 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1975 caaaagtata gcagtgcccc attcact 27 <210> 1976 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1976 Gln Lys Tyr Ser Ser Ala Pro Phe Thr 1 5 <210> 1977 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1977 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggacac cctgtccctc 60 acctgcgctg tctctggtta ctccataaac agtaataact ggtggggttg gatccggcag 120 cccccaggga agggactgga gtggattggg tacatctatt ataatgggaa catctactac 180 aacccgtccc tcaagagtcg agtcaccatg tcagtagaca cgtccgagaa ccagttctcc 240 ctgaagctga gctctgtgac cgccgtggac acggccgtgt attactgtgc gaggtgtatt 300 acgatttttg gagtggttat ctccgctttt gatgtctggg gccaagggac aatggtcacc 360 gtctcttca 369 <210> 1978 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1978 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Asn Ser Asn 20 25 30 Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Tyr Ile Tyr Tyr Asn Gly Asn Ile Tyr Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Glu Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Cys Ile Thr Ile Phe Gly Val Val Ile Ser Ala Phe Asp Val 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 1979 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1979 ggttactcca taaacagtaa taactgg 27 <210> 1980 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1980 Gly Tyr Ser Ile Asn Ser Asn Asn Trp 1 5 <210> 1981 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1981 atctattata atgggaacat c 21 <210> 1982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1982 Ile Tyr Tyr Asn Gly Asn Ile 1 5 <210> 1983 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1983 gcgaggtgta ttacgatttt tggagtggtt atctccgctt ttgatgtc 48 <210> 1984 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1984 Ala Arg Cys Ile Thr Ile Phe Gly Val Val Ile Ser Ala Phe Asp Val 1 5 10 15 <210> 1985 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1985 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 1986 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1986 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1987 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1987 cagagcatta gcagctat 18 <210> 1988 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1988 Gln Ser Ile Ser Ser Tyr 1 5 <210> 1989 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1989 gctgcatcc 9 <210> 1990 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1990 Ala Ala Ser 1 <210> 1991 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1991 caacagagtt acagtacccc gtacact 27 <210> 1992 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1992 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 1993 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1993 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtaa catatactac 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcattgtat 240 ctgcaaatga acagcctgac agccgaggac acggctgttt attactgtgc ggtgggatat 300 gggtggctac gattgtgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 1994 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1994 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Val Gly Tyr Gly Trp Leu Arg Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 1995 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1995 ggattcacct tcagtagtta tgaa 24 <210> 1996 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1996 Gly Phe Thr Phe Ser Ser Tyr Glu 1 5 <210> 1997 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1997 attagtagta gtggtagtaa cata 24 <210> 1998 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 1998 Ile Ser Ser Ser Gly Ser Asn Ile 1 5 <210> 1999 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 1999 gcggtgggat atgggtggct acgattg 27 <210> 2000 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2000 Ala Val Gly Tyr Gly Trp Leu Arg Leu 1 5 <210> 2001 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2001 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 ctcacttgcc gggcgagtca gggcattagc ttttatttag cctggtatca gcagaaacca 120 gggaaagttc ctaacctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2002 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2002 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Gly Ile Ser Phe Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2003 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2003 cagggcatta gcttttat 18 <210> 2004 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2004 Gln Gly Ile Ser Phe Tyr 1 5 <210> 2005 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2005 gctgcatcc 9 <210> 2006 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2006 Ala Ala Ser 1 <210> 2007 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2007 caaaagtata acagtgcccc attcact 27 <210> 2008 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2008 Gln Lys Tyr Asn Ser Ala Pro Phe Thr 1 5 <210> 2009 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2009 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctgtgcca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaggtaa taaatactat 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga atagcctgag agccgaggac acggctgtct attactgtgc gagagattta 300 tttttggagc ccccctacaa ctactacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 2010 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2010 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Cys 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Phe Leu Glu Pro Pro Tyr Asn Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2011 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2011 ggattcacct tcagtagctg tgcc 24 <210> 2012 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2012 Gly Phe Thr Phe Ser Ser Cys Ala 1 5 <210> 2013 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2013 atatggtatg atggaggtaa taaa 24 <210> 2014 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2014 Ile Trp Tyr Asp Gly Gly Asn Lys 1 5 <210> 2015 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2015 gcgagagatt tatttttgga gcccccctac aactactacg gtatggacgt c 51 <210> 2016 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2016 Ala Arg Asp Leu Phe Leu Glu Pro Pro Tyr Asn Tyr Tyr Gly Met Asp 1 5 10 15 Val <210> 2017 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2017 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattacc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgct gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagattttg caacatatta ttgtcaacac tatgataatt ttccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2018 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2018 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asp Asn Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2019 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2019 caggacatta ccaactat 18 <210> 2020 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2020 Gln Asp Ile Thr Asn Tyr 1 5 <210> 2021 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2021 gctgcatcc 9 <210> 2022 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2022 Ala Ala Ser 1 <210> 2023 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2023 caacactatg ataattttcc gctcact 27 <210> 2024 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2024 Gln His Tyr Asp Asn Phe Pro Leu Thr 1 5 <210> 2025 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2025 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct 120 ccagggaagg gactggagtg ggtttcatac ataagtagta gtggtagtaa tatatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgtcaagaa ttcattgtat 240 ctgcaaataa acagcctgac agccgaggac acggctgttt attactgtgc ggtgggatat 300 gggtggctac gattgtgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 2026 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2026 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Ile Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Val Gly Tyr Gly Trp Leu Arg Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 2027 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2027 ggattcacct tcagtagtta tgaa 24 <210> 2028 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2028 Gly Phe Thr Phe Ser Ser Tyr Glu 1 5 <210> 2029 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2029 ataagtagta gtggtagtaa tata 24 <210> 2030 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2030 Ile Ser Ser Ser Gly Ser Asn Ile 1 5 <210> 2031 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2031 gcggtgggat atgggtggct acgattg 27 <210> 2032 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2032 Ala Val Gly Tyr Gly Trp Leu Arg Leu 1 5 <210> 2033 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2033 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattagc ttttatttag cctggtatca gcagaaacca 120 gggaaacttc ctaacctcct gatctatgct gcatccactt tgcaatcagg ggtcccatcc 180 cggttcagtg gcagtggatc tgggacagat ttcactctca cgatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2034 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2034 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Phe Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Leu Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2035 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2035 cagggcatta gcttttat 18 <210> 2036 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2036 Gln Gly Ile Ser Phe Tyr 1 5 <210> 2037 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2037 gctgcatcc 9 <210> 2038 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2038 Ala Ala Ser 1 <210> 2039 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2039 caaaagtata acagtgcccc attcact 27 <210> 2040 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2040 Gln Lys Tyr Asn Ser Ala Pro Phe Thr 1 5 <210> 2041 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2041 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatgctgg gcccttcagt ggttactttt ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac aaactacaac 180 ccgtccctca ggagtcgagt caccatatca gtagatacgt ccaataacca gttctccctg 240 aaactgagct ctgtgaccgc cgcggacacg gctaattatt actgtgcgag aggccgagag 300 atactcgttt actactttga ctactggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 2042 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2042 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Ala Gly Pro Phe Ser Gly Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Arg 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Asn Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Asn Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Glu Ile Leu Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 2043 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2043 gctgggccct tcagtggtta cttt 24 <210> 2044 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2044 Ala Gly Pro Phe Ser Gly Tyr Phe 1 5 <210> 2045 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2045 atcaatcata gtggaagcac a 21 <210> 2046 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2046 Ile Asn His Ser Gly Ser Thr 1 5 <210> 2047 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2047 gcgagaggcc gagagatact cgtttactac tttgactac 39 <210> 2048 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2048 Ala Arg Gly Arg Glu Ile Leu Val Tyr Tyr Phe Asp Tyr 1 5 10 <210> 2049 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2049 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattgat tactggttgg cctggtatca gcagagacca 120 gggaaagccc ctaaactcct gatctataag gcgtctactt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccgtcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tatcatagtt attcgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2050 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2050 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Tyr Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2051 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2051 cagagtattg attactgg 18 <210> 2052 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2052 Gln Ser Ile Asp Tyr Trp 1 5 <210> 2053 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2053 aaggcgtct 9 <210> 2054 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2054 Lys Ala Ser 1 <210> 2055 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2055 caacagtatc atagttattc gtacact 27 <210> 2056 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2056 Gln Gln Tyr His Ser Tyr Ser Tyr Thr 1 5 <210> 2057 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2057 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gaccttcaat ttttaccagt ggagttggat ccgccagccc 120 ccagggaagg gtctggagtg gattggggaa atcaatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatttca gtagacacgt ccaagaccca gttctccctg 240 aaggtgagct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag aggcccctct 300 tcaataacta cggactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2058 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2058 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Thr Phe Asn Phe Tyr 20 25 30 Gln Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Thr Gln Phe Ser Leu 65 70 75 80 Lys Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Ser Ser Ile Thr Thr Asp Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2059 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2059 ggtgggacct tcaattttta ccag 24 <210> 2060 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2060 Gly Gly Thr Phe Asn Phe Tyr Gln 1 5 <210> 2061 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2061 atcaatcata ctggaagcac c 21 <210> 2062 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2062 Ile Asn His Thr Gly Ser Thr 1 5 <210> 2063 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2063 gcgagaggcc cctcttcaat aactacggac tactacggta tggacgtc 48 <210> 2064 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2064 Ala Arg Gly Pro Ser Ser Ile Thr Thr Asp Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 2065 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2065 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagcca gagtgttagt atcaactact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggcg cctcatctat gaaacattta gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggtg actcaccgta cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 2066 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2066 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Leu 35 40 45 Ile Tyr Glu Thr Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2067 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2067 cagagtgtta gtatcaacta c 21 <210> 2068 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2068 Gln Ser Val Ser Ile Asn Tyr 1 5 <210> 2069 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2069 gaaacattt 9 <210> 2070 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2070 Glu Thr Phe 1 <210> 2071 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2071 cagcagtatg gtgactcacc gtacact 27 <210> 2072 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2072 Gln Gln Tyr Gly Asp Ser Pro Tyr Thr 1 5 <210> 2073 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2073 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctaagactc 60 tcctgtgtaa tctctggatt catctttagg agttatgcca tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaggt gtaagtggta gtggtgatac cacaaactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtgttt 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatttt 300 ctgggaacta ccttctacgg tatggacgtc tggggccatg ggaccacggt caccgtctcc 360 tca 363 <210> 2074 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2074 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Phe Ile Phe Arg Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Val Ser Gly Ser Gly Asp Thr Thr Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Phe Leu Gly Thr Thr Phe Tyr Gly Met Asp Val Trp Gly 100 105 110 His Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2075 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2075 ggattcatct ttaggagtta tgcc 24 <210> 2076 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2076 Gly Phe Ile Phe Arg Ser Tyr Ala 1 5 <210> 2077 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2077 gtaagtggta gtggtgatac caca 24 <210> 2078 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2078 Val Ser Gly Ser Gly Asp Thr Thr 1 5 <210> 2079 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2079 gcgaaagatt ttctgggaac taccttctac ggtatggacg tc 42 <210> 2080 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2080 Ala Lys Asp Phe Leu Gly Thr Thr Phe Tyr Gly Met Asp Val 1 5 10 <210> 2081 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2081 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc aggttcttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgaa acatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattgtg cagtttatta ctgtcagcag cggaacaact ggcctcctat tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2082 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2082 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Glu Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Cys Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro Pro 85 90 95 Ile Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2083 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2083 cagagtgtta gcaggttc 18 <210> 2084 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2084 Gln Ser Val Ser Arg Phe 1 5 <210> 2085 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2085 gaaacatcc 9 <210> 2086 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2086 Glu Thr Ser 1 <210> 2087 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2087 cagcagcgga acaactggcc tcctatt 27 <210> 2088 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2088 Gln Gln Arg Asn Asn Trp Pro Pro Ile 1 5 <210> 2089 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2089 caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagc aactactata tgagctggat ccgccagtct 120 ccagggaagg gactggaatg ggtctcatat attagtaata gtggtagtac catatcttat 180 gcagactctg tgcagggccg attcaccatc tccagggaca acgccaagaa ctcactgttt 240 ctacaaatga acagcctgag ggccgaggac acggccgcat attactgtgc gagagagggt 300 atcgcacctg ctggcctctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 2090 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2090 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Tyr Met Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Asn Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val 50 55 60 Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ala Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Ile Ala Pro Ala Gly Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2091 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2091 ggattcacct tcagcaacta ctat 24 <210> 2092 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2092 Gly Phe Thr Phe Ser Asn Tyr Tyr 1 5 <210> 2093 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2093 attagtaata gtggtagtac cata 24 <210> 2094 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2094 Ile Ser Asn Ser Gly Ser Thr Ile 1 5 <210> 2095 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2095 gcgagagagg gtatcgcacc tgctggcctc tttgactac 39 <210> 2096 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2096 Ala Arg Glu Gly Ile Ala Pro Ala Gly Leu Phe Asp Tyr 1 5 10 <210> 2097 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2097 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcgagtca ggccattaga agttatttag cctggtatca gaagagacca 120 gggaaagttc ctaaactcct gatctatgct gcatccactt tacattcagg ggtcccatct 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgtta caacttatta ctgtcaaaac tataacagtc ccccgtggac attcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 2098 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2098 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Arg Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Lys Arg Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Thr Thr Tyr Tyr Cys Gln Asn Tyr Asn Ser Pro Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2099 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2099 caggccatta gaagttat 18 <210> 2100 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2100 Gln Ala Ile Arg Ser Tyr 1 5 <210> 2101 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2101 gctgcatcc 9 <210> 2102 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2102 Ala Ala Ser 1 <210> 2103 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2103 caaaactata acagtccccc gtggaca 27 <210> 2104 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2104 Gln Asn Tyr Asn Ser Pro Pro Trp Thr 1 5 <210> 2105 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2105 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcaat agctttgcat tccactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatattat 180 ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agtcgaggac acggctatat attattgtgc gagggatttc 300 tttttggagc ccccctatca ttactacgga atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 2106 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2106 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 20 25 30 Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Asp Phe Phe Leu Glu Pro Pro Tyr His Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2107 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2107 ggattcacct tcaatagctt tgca 24 <210> 2108 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2108 Gly Phe Thr Phe Asn Ser Phe Ala 1 5 <210> 2109 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2109 atatggtatg atggaagtaa taaa 24 <210> 2110 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2110 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 2111 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2111 gcgagggatt tctttttgga gcccccctat cattactacg gaatggacgt c 51 <210> 2112 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2112 Ala Arg Asp Phe Phe Leu Glu Pro Pro Tyr His Tyr Tyr Gly Met Asp 1 5 10 15 Val <210> 2113 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2113 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacctgcc aggcgagtca ggacattatc aactatttaa attggtatca acagaaacca 120 gggaaagccc ctaagctcct tatttacgct gcatccactt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagaac cctgcagcct 240 gaagatcttg caacatatta ctgtcaacaa tatgataatc tccccctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2114 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2114 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ile Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Arg Thr Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2115 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2115 caggacatta tcaactat 18 <210> 2116 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2116 Gln Asp Ile Ile Asn Tyr 1 5 <210> 2117 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2117 gctgcatcc 9 <210> 2118 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2118 Ala Ala Ser 1 <210> 2119 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2119 caacaatatg ataatctccc cctcact 27 <210> 2120 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2120 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 2121 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2121 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagtt 120 ccagggaagg gcctggagtg ggtctcaggc attagttgga atagtgataa tgtcgactat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag acctgaagac acggccttgt attactgtgc aaaagatgta 300 gatatactgg ccccctacgg aatggacgtc tggggccaag ggacaatggt caccgtctcc 360 tca 363 <210> 2122 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2122 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Asn Val Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Val Asp Ile Leu Ala Pro Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2123 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2123 ggattcacct ttgatgatta tgcc 24 <210> 2124 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2124 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 2125 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2125 attagttgga atagtgataa tgtc 24 <210> 2126 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2126 Ile Ser Trp Asn Ser Asp Asn Val 1 5 <210> 2127 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2127 gcaaaagatg tagatatact ggccccctac ggaatggacg tc 42 <210> 2128 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2128 Ala Lys Asp Val Asp Ile Leu Ala Pro Tyr Gly Met Asp Val 1 5 10 <210> 2129 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2129 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagcctcc 60 ctctcctgca gggccagtca gattgttaac agcaactact ttgcctggta ccaacagaaa 120 cctggccact ctcccaggct cctcctctat ggtccatcca ggagggccac tggtatccca 180 gacacgttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagacttgag 240 cctgaagatt ttgcatttta ttactgtcag cactatggta tctcatacat gtatgcgttt 300 ggccagggga ccaaggtgga gatcaaacga 330 <210> 2130 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2130 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Ser Leu Ser Cys Arg Ala Ser Gln Ile Val Asn Ser Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Arg Leu Leu 35 40 45 Leu Tyr Gly Pro Ser Arg Arg Ala Thr Gly Ile Pro Asp Thr Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Phe Tyr Tyr Cys Gln His Tyr Gly Ile Ser Tyr 85 90 95 Met Tyr Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 <210> 2131 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2131 cagattgtta acagcaacta c 21 <210> 2132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2132 Gln Ile Val Asn Ser Asn Tyr 1 5 <210> 2133 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2133 ggtccatcc 9 <210> 2134 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2134 Gly Pro Ser 1 <210> 2135 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2135 cagcactatg gtatctcata catgtatgcg 30 <210> 2136 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2136 Gln His Tyr Gly Ile Ser Tyr Met Tyr Ala 1 5 10 <210> 2137 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2137 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgaaactc 60 tcctgtgtag cctcaggatt cacctttgat gattatgata tgtattgggt ccggcaagtt 120 ccagggaagg gcctggagtg ggtctcaact ataagttgga atagtgaaaa catagactac 180 gcggactctg tcaagggccg attcaccatc tccagagaca acgccgagaa ctccctgtat 240 ttgcaaatga acagtctgag agctgaggac acggccttgt attactgtac aaaaaatata 300 gatatattgg ccccctatgg aatggacgtc tggggccaag ggaccacggt caccgtctcc 360 tca 363 <210> 2138 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2138 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Asp Met Tyr Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Trp Asn Ser Glu Asn Ile Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Thr Lys Asn Ile Asp Ile Leu Ala Pro Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2139 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2139 ggattcacct ttgatgatta tgat 24 <210> 2140 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2140 Gly Phe Thr Phe Asp Asp Tyr Asp 1 5 <210> 2141 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2141 ataagttgga atagtgaaaa cata 24 <210> 2142 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2142 Ile Ser Trp Asn Ser Glu Asn Ile 1 5 <210> 2143 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2143 acaaaaaata tagatatatt ggccccctat ggaatggacg tc 42 <210> 2144 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2144 Thr Lys Asn Ile Asp Ile Leu Ala Pro Tyr Gly Met Asp Val 1 5 10 <210> 2145 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2145 gacatcctga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctatcctgca gggccagtca gattattaac agcaactatt tggcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gaagggccac tggcatcccc 180 gataggttca gtcgcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtcta ttactgtcag cactatggta gttcatacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2146 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2146 Asp Ile Leu Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ile Ile Asn Ser Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Arg Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2147 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2147 cagattatta acagcaacta t 21 <210> 2148 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2148 Gln Ile Ile Asn Ser Asn Tyr 1 5 <210> 2149 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2149 ggtgcatcc 9 <210> 2150 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2150 Gly Ala Ser 1 <210> 2151 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2151 cagcactatg gtagttcata cact 24 <210> 2152 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2152 Gln His Tyr Gly Ser Ser Tyr Thr 1 5 <210> 2153 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2153 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gaatatgcca tgcactgggt ccggcaagtt 120 ccagggaagg gcctggagtg ggtctcaggt attagttggg atggtggtaa cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag acctgaggac acggccttgt attactgttc aaaagatatt 300 gtactagtac caactgggga ctactactac tacgctatgg acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2154 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2154 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asp Gly Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ser Lys Asp Ile Val Leu Val Pro Thr Gly Asp Tyr Tyr Tyr Tyr Ala 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2155 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2155 ggattcacct ttgatgaata tgcc 24 <210> 2156 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2156 Gly Phe Thr Phe Asp Glu Tyr Ala 1 5 <210> 2157 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2157 attagttggg atggtggtaa cata 24 <210> 2158 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2158 Ile Ser Trp Asp Gly Gly Asn Ile 1 5 <210> 2159 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2159 tcaaaagata ttgtactagt accaactggg gactactact actacgctat ggacgtc 57 <210> 2160 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2160 Ser Lys Asp Ile Val Leu Val Pro Thr Gly Asp Tyr Tyr Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2161 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2161 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattatc agctggttag cctggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcaa cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2162 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2162 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ile Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2163 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2163 cagggtatta tcagctgg 18 <210> 2164 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2164 Gln Gly Ile Ile Ser Trp 1 5 <210> 2165 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2165 gctgcatcc 9 <210> 2166 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2166 Ala Ala Ser 1 <210> 2167 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2167 caacaggcta acagtttccc attcact 27 <210> 2168 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2168 Gln Gln Ala Asn Ser Phe Pro Phe Thr 1 5 <210> 2169 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2169 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg tttctggata caacttttcc aaatactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctagagtg gatgggattc atctatcctg gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccctc tcagccgaca agtccatcaa caccgcctac 240 ctgcagtgga acagcctgaa ggcctcggac accgccatgt acttctgtgc gagacagggg 300 agatatatat ctgcagctgg taattttgac tactggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 2170 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2170 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Asn Phe Ser Lys Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Leu Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 85 90 95 Ala Arg Gln Gly Arg Tyr Ile Ser Ala Ala Gly Asn Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2171 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2171 ggatacaact tttccaaata ctgg 24 <210> 2172 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2172 Gly Tyr Asn Phe Ser Lys Tyr Trp 1 5 <210> 2173 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2173 atctatcctg gtgactctga tacc 24 <210> 2174 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2174 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 2175 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2175 gcgagacagg ggagatatat atctgcagct ggtaattttg actac 45 <210> 2176 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2176 Ala Arg Gln Gly Arg Tyr Ile Ser Ala Ala Gly Asn Phe Asp Tyr 1 5 10 15 <210> 2177 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2177 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc acctatttaa attggtatca acagaaacca 120 gggaaagccc ctaaggtcct gatctatgct gtatccaatt tacaaagtgg ggtcccatca 180 aggttcagtg gcagtggctc tgagacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ctgtcaacag acttacagtc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2178 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2178 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Ala Val Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2179 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2179 cagagcatta gcacctat 18 <210> 2180 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2180 Gln Ser Ile Ser Thr Tyr 1 5 <210> 2181 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2181 gctgtatcc 9 <210> 2182 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2182 Ala Val Ser 1 <210> 2183 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2183 caacagactt acagtctccc gctcact 27 <210> 2184 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2184 Gln Gln Thr Tyr Ser Leu Pro Leu Thr 1 5 <210> 2185 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2185 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccattagt agttactact ggagctggat ccgacagtcc 120 ccagggaagg gactggagtg gattggctat atctattaca gtgggaggac caattataat 180 ccctctctca agagtcgggt caccatatca gtagactcgt ccaagaatca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag gggggctagt 300 tcttctgact actactattt cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2186 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2186 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ala Ser Ser Ser Asp Tyr Tyr Tyr Phe Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2187 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2187 ggtggctcca ttagtagtta ctac 24 <210> 2188 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2188 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 2189 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2189 atctattaca gtgggaggac c 21 <210> 2190 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2190 Ile Tyr Tyr Ser Gly Arg Thr 1 5 <210> 2191 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2191 gcgagggggg ctagttcttc tgactactac tatttcggta tggacgtc 48 <210> 2192 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2192 Ala Arg Gly Ala Ser Ser Ser Asp Tyr Tyr Tyr Phe Gly Met Asp Val 1 5 10 15 <210> 2193 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2193 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gaatatttta tacagctcca acactaagac ctacttagct 120 tggtaccagc agaaaccagg gcagcctcct aaactgctca tttactgggc atctacccgg 180 gaatcctggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgctgactga agatgtggca atttatttct gtcaacaata ctataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 2194 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2194 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Ile Leu Tyr Ser 20 25 30 Ser Asn Thr Lys Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Trp Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Leu Thr Glu Asp Val Ala Ile Tyr Phe Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 2195 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2195 cagaatattt tatacagctc caacactaag acctac 36 <210> 2196 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2196 Gln Asn Ile Leu Tyr Ser Ser Asn Thr Lys Thr Tyr 1 5 10 <210> 2197 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2197 tgggcatct 9 <210> 2198 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2198 Trp Ala Ser 1 <210> 2199 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2199 caacaatact ataatactcc gtggacg 27 <210> 2200 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2200 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 2201 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2201 gaggtgcagc tggtggagtc tgggggagaa ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgaca tgcactgggt ccggcaagct 120 ccagggaatg gcctggagtg ggtctcaggt attagttgga atagtggtag tataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaaaatgtg 300 gatatagtgg ccccctacgg tatggacgtc tggggccaag ggaccacggt caccgtctcc 360 tca 363 <210> 2202 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2202 Glu Val Gln Leu Val Glu Ser Gly Gly Glu Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asn Val Asp Ile Val Ala Pro Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2203 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2203 ggattcacct ttgatgatta tgac 24 <210> 2204 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2204 Gly Phe Thr Phe Asp Asp Tyr Asp 1 5 <210> 2205 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2205 attagttgga atagtggtag tata 24 <210> 2206 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2206 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 2207 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2207 gcaaaaaatg tggatatagt ggccccctac ggtatggacg tc 42 <210> 2208 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2208 Ala Lys Asn Val Asp Ile Val Ala Pro Tyr Gly Met Asp Val 1 5 10 <210> 2209 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2209 gacatcctga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cactatggta gctcatacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2210 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2210 Asp Ile Leu Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2211 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2211 cagagtgtta gcagcagcta c 21 <210> 2212 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2212 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 2213 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2213 ggtgcatcc 9 <210> 2214 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2214 Gly Ala Ser 1 <210> 2215 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2215 cagcactatg gtagctcata cact 24 <210> 2216 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2216 Gln His Tyr Gly Ser Ser Tyr Thr 1 5 <210> 2217 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2217 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggaat cacctttgat gattatgcca tgcactgggt ccggcaaggt 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtaa tataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa atccctgtat 240 ctgcaaatga atagtctgag agctgaggac acggccttgt attactgtgc aaaagatata 300 gcagcagctg gtctttacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 2218 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2218 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2219 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2219 ggaatcacct ttgatgatta tgcc 24 <210> 2220 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2220 Gly Ile Thr Phe Asp Asp Tyr Ala 1 5 <210> 2221 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2221 attagttgga atagtggtaa tata 24 <210> 2222 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2222 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 2223 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2223 gcaaaagata tagcagcagc tggtctttac tactacggta tggacgtc 48 <210> 2224 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2224 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 2225 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2225 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgctttag gctggtatca tcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacag gttaatagtt acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2226 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2226 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Ala 20 25 30 Leu Gly Trp Tyr His Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2227 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2227 caggacatta gaaatgct 18 <210> 2228 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2228 Gln Asp Ile Arg Asn Ala 1 5 <210> 2229 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2229 gctgcatcc 9 <210> 2230 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2230 Ala Ala Ser 1 <210> 2231 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2231 ctacaggtta atagttaccc attcact 27 <210> 2232 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2232 Leu Gln Val Asn Ser Tyr Pro Phe Thr 1 5 <210> 2233 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2233 gaggtgcagc tggtggagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60 acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg 120 cagtccccat cgagaggcct tgagtggctg ggaaggacat attataggtt taagtggtat 180 aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac 240 cagttctccc tgcagttgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca 300 agtggggact ggaactatca ctttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 2234 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2234 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 20 25 30 Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Thr Tyr Tyr Arg Phe Lys Trp Tyr Asn Asp Tyr Ala 50 55 60 Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Ala Ser Gly Asp Trp Asn Tyr His Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2235 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2235 ggggacagtg tctctagcaa cagtgctgct 30 <210> 2236 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2236 Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 1 5 10 <210> 2237 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2237 acatattata ggtttaagtg gtataat 27 <210> 2238 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2238 Thr Tyr Tyr Arg Phe Lys Trp Tyr Asn 1 5 <210> 2239 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2239 gcaagtgggg actggaacta tcactttgac tac 33 <210> 2240 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2240 Ala Ser Gly Asp Trp Asn Tyr His Phe Asp Tyr 1 5 10 <210> 2241 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2241 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccaatt tacaaattgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaacag tctgcaacct 240 gaagattttg cagcttacta ctgtcaacag agttacagaa ccccgtacac ttttggcctg 300 gggaccaagg tggagatcaa acga 324 <210> 2242 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2242 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ile Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Ser Tyr Arg Thr Pro Tyr 85 90 95 Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2243 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2243 cagagcatta gcaactat 18 <210> 2244 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2244 Gln Ser Ile Ser Asn Tyr 1 5 <210> 2245 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2245 gctgcatcc 9 <210> 2246 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2246 Ala Ala Ser 1 <210> 2247 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2247 caacagagtt acagaacccc gtacact 27 <210> 2248 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2248 Gln Gln Ser Tyr Arg Thr Pro Tyr Thr 1 5 <210> 2249 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2249 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccggcagcac 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaaa 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgagtt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agataccatt 300 gattactatg gttcggggag ttcaagctac tactactacg gtatggacat ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 2250 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2250 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Lys Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Thr Ile Asp Tyr Tyr Gly Ser Gly Ser Ser Ser Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2251 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2251 ggtggctcca tcagtaatta ctac 24 <210> 2252 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2252 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 2253 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2253 atctattaca gtgggagcac c 21 <210> 2254 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2254 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 2255 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2255 gcgagagata ccattgatta ctatggttcg gggagttcaa gctactacta ctacggtatg 60 gacatc 66 <210> 2256 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2256 Ala Arg Asp Thr Ile Asp Tyr Tyr Gly Ser Gly Ser Ser Ser Tyr Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Ile 20 <210> 2257 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2257 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcggagtgg aggctgagga tgttggggtt tattactgca tgcaatctct acaaagtccg 300 tggacgttcg gccaagggac caaggtggaa atcaaacga 339 <210> 2258 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2258 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 85 90 95 Leu Gln Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2259 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2259 cagagcctcc tgcatagtaa tggatacaac tat 33 <210> 2260 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2260 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 2261 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2261 ttgggttct 9 <210> 2262 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2262 Leu Gly Ser 1 <210> 2263 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2263 atgcaatctc tacaaagtcc gtggacg 27 <210> 2264 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2264 Met Gln Ser Leu Gln Ser Pro Trp Thr 1 5 <210> 2265 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2265 caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagaa cctcacgctg 60 acctgcacct tctctgggtt ctcactcacc actagtggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt ggaatcattt attggaatga tgataaacgc 180 tacagcccat ctctaaagag caggctcacc atcagcaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga 300 agttatagca gtaactggcc ctactactac tacggtatgg acatttgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2266 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2266 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Asn Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ser Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2267 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2267 gggttctcac tcaccactag tggagtgggt 30 <210> 2268 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2268 Gly Phe Ser Leu Thr Thr Ser Gly Val Gly 1 5 10 <210> 2269 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2269 atttattgga atgatgataa a 21 <210> 2270 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2270 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2271 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2271 gcacacagaa gttatagcag taactggccc tactactact acggtatgga catt 54 <210> 2272 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2272 Ala His Arg Ser Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Ile <210> 2273 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2273 gacatcctga tgacccagtc tccctcttcc gtgtctgcat ctgttggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattaag aactggttag cctggtatca gcagaaacca 120 gggaaagccc ctaggctcct gatctatgat tcatccagtt tgcaaagtgg ggtctcatca 180 aggttcagcg gcagtggatt tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacactt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2274 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2274 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Lys Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2275 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2275 cagggtatta agaactgg 18 <210> 2276 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2276 Gln Gly Ile Lys Asn Trp 1 5 <210> 2277 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2277 gattcatcc 9 <210> 2278 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2278 Asp Ser Ser 1 <210> 2279 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2279 caacaggcta acactttccc attcact 27 <210> 2280 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2280 Gln Gln Ala Asn Thr Phe Pro Phe Thr 1 5 <210> 2281 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2281 caggtgcagc tggtggagtc tggtcctacg ctcgtgaaac ccactcagaa cctcacgctg 60 acctgcacct tctctgggtt ctcactcacc actactggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt gcaatcattt attggaatga tgataaacgc 180 tacagcccat ctctaaagag cagggtcacc atcagcaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga 300 agttatagca gtagctggcc ctactactac tacggtatgg acgtttgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2282 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2282 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Asn Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Thr 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ser Tyr Ser Ser Ser Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2283 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2283 gggttctcac tcaccactac tggagtgggt 30 <210> 2284 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2284 Gly Phe Ser Leu Thr Thr Thr Gly Val Gly 1 5 10 <210> 2285 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2285 atttattgga atgatgataa a 21 <210> 2286 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2286 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2287 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2287 gcacacagaa gttatagcag tagctggccc tactactact acggtatgga cgtt 54 <210> 2288 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2288 Ala His Arg Ser Tyr Ser Ser Ser Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2289 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2289 gacatccaga tgacccagtc tccctcttcc gtgtctgcct ctgttggaga cagagtcacc 60 atcacttgtc gggcgagtca cggtattagg aactggttag cctggtatca gcagaaacca 120 gagaaagccc ctaggctcct gatctatgat tcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcggtggatt tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacactt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2290 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2290 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2291 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2291 cacggtatta ggaactgg 18 <210> 2292 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2292 His Gly Ile Arg Asn Trp 1 5 <210> 2293 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2293 gattcatcc 9 <210> 2294 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2294 Asp Ser Ser 1 <210> 2295 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2295 caacaggcta acactttccc attcact 27 <210> 2296 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2296 Gln Gln Ala Asn Thr Phe Pro Phe Thr 1 5 <210> 2297 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2297 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cctcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccctcagt agttactact ggagctggat ccggcagttc 120 cccgataagg gactggagtg gattggattt atttattata ctggaagcag tgactacaat 180 ccctccctca agagtcgagt cagcatatca gtagacacgg ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccatttatt actgtggtag agatttttgg 300 gcagctcact actactacta cggtatcgac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2298 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2298 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Phe Pro Asp Lys Gly Leu Glu Trp Ile 35 40 45 Gly Phe Ile Tyr Tyr Thr Gly Ser Ser Asp Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ala Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Gly 85 90 95 Arg Asp Phe Trp Ala Ala His Tyr Tyr Tyr Tyr Gly Ile Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2299 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2299 ggtggctccc tcagtagtta ctac 24 <210> 2300 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2300 Gly Gly Ser Leu Ser Ser Tyr Tyr 1 5 <210> 2301 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2301 atttattata ctggaagcag t 21 <210> 2302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2302 Ile Tyr Tyr Thr Gly Ser Ser 1 5 <210> 2303 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2303 ggtagagatt tttgggcagc tcactactac tactacggta tcgacgtc 48 <210> 2304 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2304 Gly Arg Asp Phe Trp Ala Ala His Tyr Tyr Tyr Tyr Gly Ile Asp Val 1 5 10 15 <210> 2305 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2305 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaggtca gaccattacc acctttttaa attggtatca gcagagacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtgattc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagactttg caacttacta ctgtcagcag agttacagtg ccccgttcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2306 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2306 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Thr Ile Thr Thr Phe 20 25 30 Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Asp Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2307 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2307 cagaccatta ccaccttt 18 <210> 2308 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2308 Gln Thr Ile Thr Thr Phe 1 5 <210> 2309 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2309 gctgcatcc 9 <210> 2310 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2310 Ala Ala Ser 1 <210> 2311 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2311 cagcagagtt acagtgcccc gttcact 27 <210> 2312 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2312 Gln Gln Ser Tyr Ser Ala Pro Phe Thr 1 5 <210> 2313 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2313 caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60 acctgcacct tctctgggtt ctcattcagt actagtggag tgggtgtggg ctggatccgt 120 cagtccccag gaaaggccct ggagtggctt gcaatcattt attggaatga tgataagcgc 180 tacagcccat ctctgaagac caggctcacc atcaccaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcaaataga 300 agatatagca gcaactggcc ctactactac tacgggatgg acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2314 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2314 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Phe Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Ser Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Asn Arg Arg Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2315 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2315 gggttctcat tcagtactag tggagtgggt 30 <210> 2316 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2316 Gly Phe Ser Phe Ser Thr Ser Gly Val Gly 1 5 10 <210> 2317 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2317 atttattgga atgatgataa g 21 <210> 2318 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2318 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2319 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2319 gcaaatagaa gatatagcag caactggccc tactactact acgggatgga cgtc 54 <210> 2320 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2320 Ala Asn Arg Arg Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2321 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2321 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtgggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattcgc aactggttag cctggtatca gcagaaacca 120 gggaaacccc ctaagctcct gatctatgat gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccattaatag cctgcagcct 240 gaagattttg cgacttacta ttgtcaacag gctaacactt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2322 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2322 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2323 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2323 cagggtattc gcaactgg 18 <210> 2324 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2324 Gln Gly Ile Arg Asn Trp 1 5 <210> 2325 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2325 gatgcatcc 9 <210> 2326 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2326 Asp Ala Ser 1 <210> 2327 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2327 caacaggcta acactttccc attcact 27 <210> 2328 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2328 Gln Gln Ala Asn Thr Phe Pro Phe Thr 1 5 <210> 2329 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2329 caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60 acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt ggaatcattt attggaatga tgataagcgc 180 tacagcccat ctctgaagag cagagtcacc atcaccaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga 300 agttatagca gcaactggcc ctactactac tacggtatga acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2330 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2330 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ser Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2331 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2331 gggttctcac tcagcactag tggagtgggt 30 <210> 2332 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2332 Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 1 5 10 <210> 2333 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2333 atttattgga atgatgataa g 21 <210> 2334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2334 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2335 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2335 gcacacagaa gttatagcag caactggccc tactactact acggtatgaa cgtc 54 <210> 2336 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2336 Ala His Arg Ser Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asn Val <210> 2337 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2337 gacatccaga tgacccagtc tccatcttcc gtgtctgcct ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattcgc aactggttag cctggtatca gcagaaacca 120 gggaaagccc ccaacctcct gatctatgat gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2338 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2338 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2339 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2339 cagggtattc gcaactgg 18 <210> 2340 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2340 Gln Gly Ile Arg Asn Trp 1 5 <210> 2341 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2341 gatgcatcc 9 <210> 2342 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2342 Asp Ala Ser 1 <210> 2343 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2343 caacaggcta acagtttccc attcact 27 <210> 2344 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2344 Gln Gln Ala Asn Ser Phe Pro Phe Thr 1 5 <210> 2345 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2345 caggtgcagc tggtggagtc tggtcctacg ctggtaaaac ccacacagac cctcacgctg 60 acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt ggaatcattt attggaatga tgataagcgc 180 tacaatccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga 300 gcgtatagca gcagctggcc ctactacttc tacggtatgg acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2346 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2346 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ala Tyr Ser Ser Ser Trp Pro Tyr Tyr Phe Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2347 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2347 gggttctcac tcagcactag tggagtgggt 30 <210> 2348 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2348 Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 1 5 10 <210> 2349 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2349 atttattgga atgatgataa g 21 <210> 2350 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2350 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2351 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2351 gcacacagag cgtatagcag cagctggccc tactacttct acggtatgga cgtc 54 <210> 2352 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2352 Ala His Arg Ala Tyr Ser Ser Ser Trp Pro Tyr Tyr Phe Tyr Gly Met 1 5 10 15 Asp Val <210> 2353 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2353 gacatccaga tgacccagtc tccatcttcc gtgtctgcct ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattcgc aactggttag cctggtatca gcagaaacca 120 gggaaagtcc ctaagctcct gatctatgat gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2354 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2354 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2355 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2355 cagggtattc gcaactgg 18 <210> 2356 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2356 Gln Gly Ile Arg Asn Trp 1 5 <210> 2357 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2357 gatgcatcc 9 <210> 2358 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2358 Asp Ala Ser 1 <210> 2359 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2359 caacaggcta acagtttccc attcact 27 <210> 2360 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2360 Gln Gln Ala Asn Ser Phe Pro Phe Thr 1 5 <210> 2361 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2361 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttagc agctattcca tgagctgggt ccgccaggct 120 ccagggaagg ggctagagtg ggtctcaact attagtggta gtggtaatag tatattctac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagag cacgctatat 240 ctacaaatga atagtctgag agtcgaggac acggccgtat attactgtgc aattgtagca 300 gctcgtcggg aggcccattt ctactactac tacaatatgg acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2362 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2362 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Gly Ser Gly Asn Ser Ile Phe Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Val Ala Ala Arg Arg Glu Ala His Phe Tyr Tyr Tyr Tyr Asn 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2363 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2363 ggattcacct ttagcagcta ttcc 24 <210> 2364 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2364 Gly Phe Thr Phe Ser Ser Tyr Ser 1 5 <210> 2365 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2365 attagtggta gtggtaatag tata 24 <210> 2366 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2366 Ile Ser Gly Ser Gly Asn Ser Ile 1 5 <210> 2367 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2367 gcaattgtag cagctcgtcg ggaggcccat ttctactact actacaatat ggacgtc 57 <210> 2368 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2368 Ala Ile Val Ala Ala Arg Arg Glu Ala His Phe Tyr Tyr Tyr Tyr Asn 1 5 10 15 Met Asp Val <210> 2369 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2369 gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgcaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggcattagt aattatttag cctggtttca gcagaaacca 120 gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg gatcccatca 180 aaattcagcg gcagtggatc tgggacagat ttcactctca ccatcagcaa cctgcagcct 240 gaagattttg caacttatta ctgccaacag tataatgatt accctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2370 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2370 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Ile Pro Ser Lys Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asp Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2371 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2371 cagggcatta gtaattat 18 <210> 2372 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2372 Gln Gly Ile Ser Asn Tyr 1 5 <210> 2373 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2373 gctgcatcc 9 <210> 2374 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2374 Ala Ala Ser 1 <210> 2375 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2375 caacagtata atgattaccc tctcact 27 <210> 2376 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2376 Gln Gln Tyr Asn Asp Tyr Pro Leu Thr 1 5 <210> 2377 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2377 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagacta 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat 180 gcggactctg tgaagggccg attcatcatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatgg acagtctgag atctgaggac acggccttat attactgtgc aagagttctt 300 acctggaact tcgtttatga tgcttttgac atctggggcc aagggacaat ggtcaccgtc 360 tcttca 366 <210> 2378 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2378 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Thr Trp Asn Phe Val Tyr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2379 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2379 ggattcacct ttgatgatta tgcc 24 <210> 2380 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2380 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 2381 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2381 attagttgga atagtggtag cata 24 <210> 2382 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2382 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 2383 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2383 gcaagagttc ttacctggaa cttcgtttat gatgcttttg acatc 45 <210> 2384 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2384 Ala Arg Val Leu Thr Trp Asn Phe Val Tyr Asp Ala Phe Asp Ile 1 5 10 15 <210> 2385 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2385 gacatcgtga tgacccagtc tccgggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtattagc agcacctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtacattca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcac caatatggta gctcaccgta cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 2386 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2386 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Thr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2387 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2387 cagagtatta gcagcaccta c 21 <210> 2388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2388 Gln Ser Ile Ser Ser Thr Tyr 1 5 <210> 2389 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2389 ggtacattc 9 <210> 2390 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2390 Gly Thr Phe 1 <210> 2391 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2391 caccaatatg gtagctcacc gtacact 27 <210> 2392 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2392 His Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 2393 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2393 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 gcctgtgcag cctctggatt cacctttagc agctatgcca tgatctgggt ccgccaggtt 120 ccagggatgg ggctggagtg ggtctcagct attagtggta gtggtggtaa cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgac agccgaggac acggccgtat attactgtgc gaagggagca 300 gctcgtggat actactatta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2394 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2394 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ile Trp Val Arg Gln Val Pro Gly Met Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ala Ala Arg Gly Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2395 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2395 ggattcacct ttagcagcta tgcc 24 <210> 2396 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2396 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 2397 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2397 attagtggta gtggtggtaa caca 24 <210> 2398 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2398 Ile Ser Gly Ser Gly Gly Asn Thr 1 5 <210> 2399 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2399 gcgaagggag cagctcgtgg atactactat tacggtatgg acgtc 45 <210> 2400 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2400 Ala Lys Gly Ala Ala Arg Gly Tyr Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 2401 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2401 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatggt gcgtccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2402 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2402 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2403 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2403 cagggcatta gaaatgat 18 <210> 2404 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2404 Gln Gly Ile Arg Asn Asp 1 5 <210> 2405 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2405 ggtgcgtcc 9 <210> 2406 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2406 Gly Ala Ser 1 <210> 2407 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2407 ctacaagatt acaattaccc attcact 27 <210> 2408 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2408 Leu Gln Asp Tyr Asn Tyr Pro Phe Thr 1 5 <210> 2409 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2409 caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg 60 acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt ggaatcattt attggaatga tgataagcgc 180 tacagcccat ctctgaagag cagactcgcc atcaccaagg acacctccaa aaaccaggtg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga 300 agttatagca gcaactggcc ctactactac tacggtatga acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2410 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2410 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Leu Ala Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ser Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2411 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2411 gggttctcac tcagcactag tggagtgggt 30 <210> 2412 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2412 Gly Phe Ser Leu Ser Thr Ser Gly Val Gly 1 5 10 <210> 2413 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2413 atttattgga atgatgataa g 21 <210> 2414 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2414 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2415 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2415 gcacacagaa gttatagcag caactggccc tactactact acggtatgaa cgtc 54 <210> 2416 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2416 Ala His Arg Ser Tyr Ser Ser Asn Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asn Val <210> 2417 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2417 gacatccaga tgacccagtc tccatcttcc gtgtctgcct ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattcgc aattggttag cctggtatca gcagaaacca 120 gggaaagccc ccaacctcct gatctatgat gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2418 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2418 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2419 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2419 cagggtattc gcaattgg 18 <210> 2420 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2420 Gln Gly Ile Arg Asn Trp 1 5 <210> 2421 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2421 gatgcatcc 9 <210> 2422 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2422 Asp Ala Ser 1 <210> 2423 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2423 caacaggcta acagtttccc attcact 27 <210> 2424 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2424 Gln Gln Ala Asn Ser Phe Pro Phe Thr 1 5 <210> 2425 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2425 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccagggt 120 ccaggcaagg ggctggagtg ggtggcactt atatcatatg atggaagtaa taaatactat 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agttgaggac acggctctgt tttactgtgt gaaagaccgg 300 gagatttttg gagtggttag gtactactac ggtatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 2426 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2426 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Val Lys Asp Arg Glu Ile Phe Gly Val Val Arg Tyr Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2427 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2427 ggattcacct tcagtagcta tggc 24 <210> 2428 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2428 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 2429 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2429 atatcatatg atggaagtaa taaa 24 <210> 2430 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2430 Ile Ser Tyr Asp Gly Ser Asn Lys 1 5 <210> 2431 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2431 gtgaaagacc gggagatttt tggagtggtt aggtactact acggtatgga cgtc 54 <210> 2432 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2432 Val Lys Asp Arg Glu Ile Phe Gly Val Val Arg Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2433 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2433 gacatcctga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catggtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacat ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggct cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactcct 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 2434 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2434 Asp Ile Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Gly 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2435 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2435 cagagcctcc tgcatggtaa tggatacaac tat 33 <210> 2436 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2436 Gln Ser Leu Leu His Gly Asn Gly Tyr Asn Tyr 1 5 10 <210> 2437 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2437 ttgggttct 9 <210> 2438 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2438 Leu Gly Ser 1 <210> 2439 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2439 atgcaagctc tacaaactcc tctcact 27 <210> 2440 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2440 Met Gln Ala Leu Gln Thr Pro Leu Thr 1 5 <210> 2441 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2441 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agtaactatt ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattcca gtgggagcac caactacaac 180 ccctccctca ggagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aacctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatgggttt 300 gattactatg gttcggggag ttcaaactac ttctactacg gtatggacgt ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 2442 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2442 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Ser Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Arg 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Phe Asp Tyr Tyr Gly Ser Gly Ser Ser Asn Tyr Phe Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2443 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2443 ggtggctcca tcagtagtaa ctat 24 <210> 2444 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2444 Gly Gly Ser Ile Ser Ser Asn Tyr 1 5 <210> 2445 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2445 atctattcca gtgggagcac c 21 <210> 2446 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2446 Ile Tyr Ser Ser Gly Ser Thr 1 5 <210> 2447 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2447 gcgagagatg ggtttgatta ctatggttcg gggagttcaa actacttcta ctacggtatg 60 gacgtc 66 <210> 2448 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2448 Ala Arg Asp Gly Phe Asp Tyr Tyr Gly Ser Gly Ser Ser Asn Tyr Phe 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 2449 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2449 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggccttc 60 atctcctgca ggtctagtca gagcctcctg cgtagtaatg gatacaacta tttggattgg 120 ctcctgcaga ggccagggca gtctccacaa ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttgggatt tattactgta tgcaaactct acagactccg 300 tggacgttcg gccaagggac caaggtggag atcaaacga 339 <210> 2450 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2450 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Phe Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Arg Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Leu Leu Gln Arg Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Thr 85 90 95 Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2451 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2451 cagagcctcc tgcgtagtaa tggatacaac tat 33 <210> 2452 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2452 Gln Ser Leu Leu Arg Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 2453 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2453 ttgggttct 9 <210> 2454 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2454 Leu Gly Ser 1 <210> 2455 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2455 atgcaaactc tacagactcc gtggacg 27 <210> 2456 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2456 Met Gln Thr Leu Gln Thr Pro Trp Thr 1 5 <210> 2457 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2457 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcaa cctctggatt cacctttagc aactatgcca tgatctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta ctggtgttag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaacaa cacgctgttt 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaattggc 300 tacggtgact tctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 2458 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2458 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Thr Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Gly Tyr Gly Asp Phe Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2459 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2459 ggattcacct ttagcaacta tgcc 24 <210> 2460 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2460 Gly Phe Thr Phe Ser Asn Tyr Ala 1 5 <210> 2461 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2461 attagtggta ctggtgttag caca 24 <210> 2462 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2462 Ile Ser Gly Thr Gly Val Ser Thr 1 5 <210> 2463 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2463 gcgaaaattg gctacggtga cttctttgac tac 33 <210> 2464 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2464 Ala Lys Ile Gly Tyr Gly Asp Phe Phe Asp Tyr 1 5 10 <210> 2465 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2465 gacatccaga tgacccagtc tccatcctcc ctgtctacat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2466 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2466 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2467 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2467 cagagcatta gcagctat 18 <210> 2468 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2468 Gln Ser Ile Ser Ser Tyr 1 5 <210> 2469 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2469 gctgcatcc 9 <210> 2470 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2470 Ala Ala Ser 1 <210> 2471 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2471 caacagagtt acagtacccc tcccact 27 <210> 2472 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2472 Gln Gln Ser Tyr Ser Thr Pro Pro Thr 1 5 <210> 2473 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2473 caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagaa cctcacgctg 60 acctgcacct tctctgggtt ctcactcacc actagtggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt ggaatcattt attggaatga tgataaacgc 180 tatagcccat ctctaaagag caggctcacc atcagcaagg acacctccaa aaaccaggtg 240 gtccttacac tgaccaacat gggccctgtg gacacagcca catattactg tgcacacaga 300 agttatagca ctaactggcc ctactactac tacggtatgg acgtttgggg ccaggggacc 360 acggtcaccg tctcctca 378 <210> 2474 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2474 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Asn Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Leu Thr Asn Met Gly Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ser Tyr Ser Thr Asn Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2475 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2475 gggttctcac tcaccactag tggagtgggt 30 <210> 2476 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2476 Gly Phe Ser Leu Thr Thr Ser Gly Val Gly 1 5 10 <210> 2477 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2477 atttattgga atgatgataa a 21 <210> 2478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2478 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2479 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2479 gcacacagaa gttatagcac taactggccc tactactact acggtatgga cgtt 54 <210> 2480 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2480 Ala His Arg Ser Tyr Ser Thr Asn Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2481 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2481 gacatccaga tgacccagtc tccctcttcc gtgtctgcat ctgttggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattagg aactggttag cctggtatca gcagaaacca 120 gggaaagccc ctaggctcct gatctatgat tcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatt tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacactt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2482 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2482 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2483 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2483 cagggtatta ggaactgg 18 <210> 2484 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2484 Gln Gly Ile Arg Asn Trp 1 5 <210> 2485 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2485 gattcatcc 9 <210> 2486 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2486 Asp Ser Ser 1 <210> 2487 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2487 caacaggcta acactttccc attcact 27 <210> 2488 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2488 Gln Gln Ala Asn Thr Phe Pro Phe Thr 1 5 <210> 2489 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2489 caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagaa cctcacgctg 60 acctgcacct tctctgggtt ctcactcacc actagtggag tgggtgtggg ctggatccgt 120 cagcccccag gaaaggccct ggagtggctt ggaatcattt attggaatga tgataaacgc 180 tacagtccat ctctaaagag caggctcacc atcaacaagg acacctccaa aaaccagctg 240 gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacaga 300 agttatagca ctaactggcc ctactactac tacggtatgg acgtttgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 2490 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2490 Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Asn Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Ile Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Asn Lys Asp Thr Ser Lys Asn Gln Leu 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala His Arg Ser Tyr Ser Thr Asn Trp Pro Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2491 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2491 gggttctcac tcaccactag tggagtgggt 30 <210> 2492 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2492 Gly Phe Ser Leu Thr Thr Ser Gly Val Gly 1 5 10 <210> 2493 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2493 atttattgga atgatgataa a 21 <210> 2494 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2494 Ile Tyr Trp Asn Asp Asp Lys 1 5 <210> 2495 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2495 gcacacagaa gttatagcac taactggccc tactactact acggtatgga cgtt 54 <210> 2496 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2496 Ala His Arg Ser Tyr Ser Thr Asn Trp Pro Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2497 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2497 gacatccaga tgacccagtc tccctcttcc gtgtctgcat ctgttggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattagg aactggttag cctggtatca gcagaaacct 120 gggaaagccc ctaggctcct gatctatgat tcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatt tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacactt tcccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2498 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2498 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2499 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2499 cagggtatta ggaactgg 18 <210> 2500 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2500 Gln Gly Ile Arg Asn Trp 1 5 <210> 2501 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2501 gattcatcc 9 <210> 2502 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2502 Asp Ser Ser 1 <210> 2503 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2503 caacaggcta acactttccc attcact 27 <210> 2504 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2504 Gln Gln Ala Asn Thr Phe Pro Phe Thr 1 5 <210> 2505 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2505 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cagctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg gtctggaatg ggtctcaggt attagtggca gtggtggtag cacattaaac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa aacgctgtat 240 ctgcaaatga gcagcctgag agccgaggac acggccgtat attactgtgc gaaagtcttt 300 gactatagct acttctacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2506 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2506 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Leu Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Phe Asp Tyr Ser Tyr Phe Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2507 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2507 ggattcagct ttagcagcta tgcc 24 <210> 2508 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2508 Gly Phe Ser Phe Ser Ser Tyr Ala 1 5 <210> 2509 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2509 attagtggca gtggtggtag caca 24 <210> 2510 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2510 Ile Ser Gly Ser Gly Gly Ser Thr 1 5 <210> 2511 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2511 gcgaaagtct ttgactatag ctacttctac tacggtatgg acgtc 45 <210> 2512 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2512 Ala Lys Val Phe Asp Tyr Ser Tyr Phe Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 2513 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2513 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtagtg gatacaacta tttggattgg 120 tacctgcaga ggccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgct tgcaagttct acaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2514 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2514 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Ser Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2515 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2515 cagagcctcc tgcatagtag tggatacaac tat 33 <210> 2516 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2516 Gln Ser Leu Leu His Ser Ser Gly Tyr Asn Tyr 1 5 10 <210> 2517 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2517 ttgggttct 9 <210> 2518 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2518 Leu Gly Ser 1 <210> 2519 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2519 ttgcaagttc tacaaactcc gtacact 27 <210> 2520 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2520 Leu Gln Val Leu Gln Thr Pro Tyr Thr 1 5 <210> 2521 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2521 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccggcagcac 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaaa 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aaactgagtt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agataccatt 300 gattactatg gttcggggag ttcaagctac tactactacg gtatggacat ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 2522 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2522 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Lys Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Thr Ile Asp Tyr Tyr Gly Ser Gly Ser Ser Ser Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2523 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2523 ggtggctcca tcagtaatta ctac 24 <210> 2524 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2524 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 2525 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2525 atctattaca gtgggagcac c 21 <210> 2526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2526 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 2527 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2527 gcgagagata ccattgatta ctatggttcg gggagttcaa gctactacta ctacggtatg 60 gacatc 66 <210> 2528 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2528 Ala Arg Asp Thr Ile Asp Tyr Tyr Gly Ser Gly Ser Ser Ser Tyr Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Ile 20 <210> 2529 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2529 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcggagtgg aggctgagga tgttggggtt tattactgca tgcaatctct acaaagtccg 300 tggacgttcg gccaagggac caaggtggag atcaaacga 339 <210> 2530 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2530 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 85 90 95 Leu Gln Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2531 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2531 cagagcctcc tgcatagtaa tggatacaac tat 33 <210> 2532 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2532 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 2533 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2533 ttgggttct 9 <210> 2534 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2534 Leu Gly Ser 1 <210> 2535 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2535 atgcaatctc tacaaagtcc gtggacg 27 <210> 2536 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2536 Met Gln Ser Leu Gln Ser Pro Trp Thr 1 5 <210> 2537 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2537 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctgatgg ctccatcagt acttactact ggagctggat ccggcagccc 120 ccaggaaagg gactggagtg gattgggtat atctattaca gtgggagaac caactacaac 180 ccctccctca agagtcgagt caccatttca gttgacacgt ccaagaacca gttctccctg 240 aagctgacct ctgtgaccgc tgcggacacg gccgtatatt actgtgcgag aggtgggagc 300 agccctaact attactactt cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2538 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2538 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Gly Ser Ser Pro Asn Tyr Tyr Tyr Phe Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2539 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2539 gatggctcca tcagtactta ctac 24 <210> 2540 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2540 Asp Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 2541 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2541 atctattaca gtgggagaac c 21 <210> 2542 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2542 Ile Tyr Tyr Ser Gly Arg Thr 1 5 <210> 2543 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2543 gcgagaggtg ggagcagccc taactattac tacttcggta tggacgtc 48 <210> 2544 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2544 Ala Arg Gly Gly Ser Ser Pro Asn Tyr Tyr Tyr Phe Gly Met Asp Val 1 5 10 15 <210> 2545 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2545 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca tgtccagcca tactatttta tacagctcca acaataagaa gtacttagct 120 tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcaccagcc tgcaggctga agatgtggca gtttattact gtcaacaata ctataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 2546 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2546 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Met Ser Ser His Thr Ile Leu Tyr Ser 20 25 30 Ser Asn Asn Lys Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Thr Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 2547 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2547 catactattt tatacagctc caacaataag aagtac 36 <210> 2548 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2548 His Thr Ile Leu Tyr Ser Ser Asn Asn Lys Lys Tyr 1 5 10 <210> 2549 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2549 tgggcatct 9 <210> 2550 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2550 Trp Ala Ser 1 <210> 2551 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2551 caacaatact ataatactcc gtggacg 27 <210> 2552 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2552 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 2553 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2553 gaggtgcagc tggtggagtc tggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaacac caactacaac 180 ccctccctca agagtcgagt caccatatct gtcgacacgt ccaagaacca gttctccctg 240 aagctgacct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agattcttat 300 tacgattttt ggagtggtta ttataccctc tggggccagg gaaccacggt caccgtctcc 360 tca 363 <210> 2554 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2554 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr Leu Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2555 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2555 ggtggctcca tcagtagtta ctac 24 <210> 2556 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2556 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 2557 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2557 atctattaca gtgggaacac c 21 <210> 2558 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2558 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 2559 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2559 gcgagagatt cttattacga tttttggagt ggttattata ccctc 45 <210> 2560 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2560 Ala Arg Asp Ser Tyr Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr Leu 1 5 10 15 <210> 2561 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2561 gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gtgggccacc 60 atcaactgca agtccagcca gagtattttg ttcagctcca acaataagaa ctacttagct 120 tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg cttcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 cctcggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 2562 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2562 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Trp Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Phe Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 2563 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2563 cagagtattt tgttcagctc caacaataag aactac 36 <210> 2564 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2564 Gln Ser Ile Leu Phe Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 2565 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2565 tgggcatct 9 <210> 2566 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2566 Trp Ala Ser 1 <210> 2567 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2567 cagcaatatt ataatactcc tcggacg 27 <210> 2568 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2568 Gln Gln Tyr Tyr Asn Thr Pro Arg Thr 1 5 <210> 2569 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2569 gaggtgcagc tggtggagtc tgggggaggc gtggtccagt ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt gactatggca tgcactgggt ccggcaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atttggtatg atggaaataa aaaagactgt 180 gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctagaaatga atagcctgag agccgaggac acggccgtgt attactgtgc gagaatgagg 300 tataactgga actcatttga ctactggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 2570 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2570 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Asn Lys Lys Asp Cys Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Arg Tyr Asn Trp Asn Ser Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 2571 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2571 ggattcacct tcagtgacta tggc 24 <210> 2572 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2572 Gly Phe Thr Phe Ser Asp Tyr Gly 1 5 <210> 2573 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2573 atttggtatg atggaaataa aaaa 24 <210> 2574 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2574 Ile Trp Tyr Asp Gly Asn Lys Lys 1 5 <210> 2575 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2575 gcgagaatga ggtataactg gaactcattt gactac 36 <210> 2576 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2576 Ala Arg Met Arg Tyr Asn Trp Asn Ser Phe Asp Tyr 1 5 10 <210> 2577 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2577 gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgaaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggtcactcac aattacttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacag tatgttaatt tccctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2578 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2578 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Glu Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Val Thr His Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Tyr Val Asn Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2579 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2579 caggtcactc acaattac 18 <210> 2580 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2580 Gln Val Thr His Asn Tyr 1 5 <210> 2581 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2581 gatgcatcc 9 <210> 2582 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2582 Asp Ala Ser 1 <210> 2583 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2583 caacagtatg ttaatttccc tctcact 27 <210> 2584 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2584 Gln Gln Tyr Val Asn Phe Pro Leu Thr 1 5 <210> 2585 <211> 351 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2585 gaggtgcagc tggtggagtc tggagctgaa atgaagaagc ctggggcctc agtgaaggtc 60 tcctgtaagg cctctggtca caccttcatc agttatggta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggatgg accagccctt acaatggtaa cacaaactat 180 gcacagaagt tccagggcag agtcaccatg accacagaca catccacgaa tacaacctac 240 atggaaatga ggagcctgag atctgacgac acggccgtat attactgtac gagaggctgg 300 ttcgatgctt ttgatatctg gggtcaaggg acaatggtca ccgtctcctc a 351 <210> 2586 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2586 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Met Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Ile Ser Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Thr Ser Pro Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Thr Tyr 65 70 75 80 Met Glu Met Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Gly Trp Phe Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 100 105 110 Val Thr Val Ser Ser 115 <210> 2587 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2587 ggtcacacct tcatcagtta tggt 24 <210> 2588 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2588 Gly His Thr Phe Ile Ser Tyr Gly 1 5 <210> 2589 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2589 accagccctt acaatggtaa caca 24 <210> 2590 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2590 Thr Ser Pro Tyr Asn Gly Asn Thr 1 5 <210> 2591 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2591 acgagaggct ggttcgatgc ttttgatatc 30 <210> 2592 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2592 Thr Arg Gly Trp Phe Asp Ala Phe Asp Ile 1 5 10 <210> 2593 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2593 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atctcttgcc ggtcacgtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtgtatc tggggcagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caactttcta ctgtcaacag agttacacta cccctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acga 324 <210> 2594 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2594 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ser Arg Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Val Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Phe Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2595 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2595 cagagcatta gcagctat 18 <210> 2596 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2596 Gln Ser Ile Ser Ser Tyr 1 5 <210> 2597 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2597 gctgcatcc 9 <210> 2598 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2598 Ala Ala Ser 1 <210> 2599 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2599 caacagagtt acactacccc tccgacg 27 <210> 2600 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2600 Gln Gln Ser Tyr Thr Thr Pro Pro Thr 1 5 <210> 2601 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2601 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aactactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatccag gtgactctga gaccagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccttat tttactgtgc gagacttggg 300 aggttcttcg acaactacta cgctatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2602 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2602 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2603 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2603 ggatacacct ttaccaacta ctgg 24 <210> 2604 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2604 Gly Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 2605 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2605 atctatccag gtgactctga gacc 24 <210> 2606 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2606 Ile Tyr Pro Gly Asp Ser Glu Thr 1 5 <210> 2607 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2607 gcgagacttg ggaggttctt cgacaactac tacgctatgg acgtc 45 <210> 2608 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2608 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val 1 5 10 15 <210> 2609 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2609 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcatt 60 atcacttgtc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcgtccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaattt 240 gcagattttg aaaattacta ctgtcaacag acttacagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2610 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2610 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Phe 65 70 75 80 Ala Asp Phe Glu Asn Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2611 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2611 cagagcatta gcacctat 18 <210> 2612 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2612 Gln Ser Ile Ser Thr Tyr 1 5 <210> 2613 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2613 ggtgcgtcc 9 <210> 2614 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2614 Gly Ala Ser 1 <210> 2615 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2615 caacagactt acagtatccc gtacact 27 <210> 2616 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2616 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2617 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2617 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt gactatggaa tgcactgggt ccggcaggct 120 ccaggcaagg gactggagtg ggtggcagtt atttggtatg atgggaataa aaaagactgt 180 gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat 240 cttcaaatga atagcctgag agccgaggac acggctgtgt attactgtgc gagaatgagg 300 tataactgga actcgtttga ctgctggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 2618 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2618 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Asn Lys Lys Asp Cys Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Arg Tyr Asn Trp Asn Ser Phe Asp Cys Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 2619 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2619 ggattcacct tcagtgacta tgga 24 <210> 2620 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2620 Gly Phe Thr Phe Ser Asp Tyr Gly 1 5 <210> 2621 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2621 atttggtatg atgggaataa aaaa 24 <210> 2622 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2622 Ile Trp Tyr Asp Gly Asn Lys Lys 1 5 <210> 2623 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2623 gcgagaatga ggtataactg gaactcgttt gactgc 36 <210> 2624 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2624 Ala Arg Met Arg Tyr Asn Trp Asn Ser Phe Asp Cys 1 5 10 <210> 2625 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2625 gacatccaga tgacccagtc tccatcctcc ctgtatgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggactctcac aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg agtcccatca 180 aggttcagtg gaagtggttc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacag tatgttaatt tccctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2626 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2626 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Tyr Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ser His Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Tyr Val Asn Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2627 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2627 caggactctc acaactat 18 <210> 2628 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2628 Gln Asp Ser His Asn Tyr 1 5 <210> 2629 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2629 gatgcatcc 9 <210> 2630 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2630 Asp Ala Ser 1 <210> 2631 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2631 caacagtatg ttaatttccc tctcact 27 <210> 2632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2632 Gln Gln Tyr Val Asn Phe Pro Leu Thr 1 5 <210> 2633 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2633 caggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aactactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatccag gtgactctga gaccagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccttat tttactgtgc gagacttggg 300 aggttcttcg acaactacta cgctatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2634 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2634 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2635 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2635 ggatacacct ttaccaacta ctgg 24 <210> 2636 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2636 Gly Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 2637 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2637 atctatccag gtgactctga gacc 24 <210> 2638 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2638 Ile Tyr Pro Gly Asp Ser Glu Thr 1 5 <210> 2639 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2639 gcgagacttg ggaggttctt cgacaactac tacgctatgg acgtc 45 <210> 2640 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2640 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val 1 5 10 15 <210> 2641 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2641 gacatcctga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggcattacc aattatttag cctggtttca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcgtccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaattt 240 gcagattttg aaaattacta ctgtcaacag acttacagta tcccgtacac ttttggccag 300 gggaccaagg tggaaatcaa acga 324 <210> 2642 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2642 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Phe 65 70 75 80 Ala Asp Phe Glu Asn Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2643 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2643 cagggcatta ccaattat 18 <210> 2644 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2644 Gln Gly Ile Thr Asn Tyr 1 5 <210> 2645 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2645 ggtgcgtcc 9 <210> 2646 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2646 Gly Ala Ser 1 <210> 2647 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2647 caacagactt acagtatccc gtacact 27 <210> 2648 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2648 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2649 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2649 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattggatat atctattaca gtgggagcac caagtacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaaaaacca gttctccctg 240 aaactgaact ctgtgaccgc tgcggacacg gccatgtatt actgtgcgag agataacggt 300 gacctctttg actactgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 2650 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2650 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 85 90 95 Arg Asp Asn Gly Asp Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 2651 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2651 ggtggctcca tcagtagtta ctac 24 <210> 2652 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2652 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 2653 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2653 atctattaca gtgggagcac c 21 <210> 2654 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2654 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 2655 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2655 gcgagagata acggtgacct ctttgactac 30 <210> 2656 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2656 Ala Arg Asp Asn Gly Asp Leu Phe Asp Tyr 1 5 10 <210> 2657 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2657 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 agcacttgcc gggcaagtca gagcattagt agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct acatccagtt tgaaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2658 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2658 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ser Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2659 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2659 cagagcatta gtagctat 18 <210> 2660 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2660 Gln Ser Ile Ser Ser Tyr 1 5 <210> 2661 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2661 gctacatcc 9 <210> 2662 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2662 Ala Thr Ser 1 <210> 2663 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2663 caacagagtt acagtatccc gtacact 27 <210> 2664 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2664 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2665 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2665 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gatcatggca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtaa cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa gtccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatata 300 gcagcagctg gtctgtttta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 2666 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2666 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Phe Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2667 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2667 ggattcacct ttgatgatca tggc 24 <210> 2668 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2668 Gly Phe Thr Phe Asp Asp His Gly 1 5 <210> 2669 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2669 attagttgga atagtggtaa cata 24 <210> 2670 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2670 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 2671 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2671 gcaaaagata tagcagcagc tggtctgttt tactacggta tggacgtc 48 <210> 2672 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2672 Ala Lys Asp Ile Ala Ala Ala Gly Leu Phe Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 2673 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2673 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtcggaga cagagtcacc 60 atcacttgct gggccagtca gggcattagc acttatttag cctggtatca gaaaaaccca 120 gggaaagccc ctaagctcct attctatgct gcctccactt tcctaactgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttgatagtt acccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2674 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2674 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Ser Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Lys Asn Pro Gly Lys Ala Pro Lys Leu Leu Phe 35 40 45 Tyr Ala Ala Ser Thr Phe Leu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2675 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2675 cagggcatta gcacttat 18 <210> 2676 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2676 Gln Gly Ile Ser Thr Tyr 1 5 <210> 2677 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2677 gctgcctcc 9 <210> 2678 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2678 Ala Ala Ser 1 <210> 2679 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2679 caacagcttg atagttaccc gctcact 27 <210> 2680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2680 Gln Gln Leu Asp Ser Tyr Pro Leu Thr 1 5 <210> 2681 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2681 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactatt ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caagtacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccac tgcggacacg gccgcgtatt actgtgcgag agatccccag 300 tattatcatg atagtagtgg ttattacggg ggttttgact actggggcca gggaaccccg 360 gtcaccgtct cctca 375 <210> 2682 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2682 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Thr Ala Asp Thr Ala Ala Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Gln Tyr Tyr His Asp Ser Ser Gly Tyr Tyr Gly Gly Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 115 120 125 <210> 2683 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2683 ggtggctcca tcagtagtta ctat 24 <210> 2684 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2684 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 2685 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2685 atctattaca gtgggagcac c 21 <210> 2686 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2686 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 2687 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2687 gcgagagatc cccagtatta tcatgatagt agtggttatt acgggggttt tgactac 57 <210> 2688 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2688 Ala Arg Asp Pro Gln Tyr Tyr His Asp Ser Ser Gly Tyr Tyr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2689 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2689 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gcgggccacc 60 atcaactgca agtccagcca gagtgtttta tacaactcca acaataagaa ctacttagct 120 tggtaccagc agaaaccagg acagacgcct aaactgctca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 ccgtacactt ttggccaggg gaccaaggtg gagatcaaac ga 342 <210> 2690 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2690 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Asn 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Thr Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 2691 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2691 cagagtgttt tatacaactc caacaataag aactac 36 <210> 2692 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2692 Gln Ser Val Leu Tyr Asn Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 2693 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2693 tgggcatct 9 <210> 2694 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2694 Trp Ala Ser 1 <210> 2695 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2695 cagcaatatt ataatactcc gtacact 27 <210> 2696 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2696 Gln Gln Tyr Tyr Asn Thr Pro Tyr Thr 1 5 <210> 2697 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2697 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattgtgcca tgcactgggt ccggctagct 120 ccagggaagg gcctggagtg tgtctcaggt attagttgga atagtggtaa cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatata 300 gcagcagctg gtctgtatta ctacggtttg gacgtctggg gccgagggac cacggtcacc 360 gtctcctca 369 <210> 2698 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2698 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Cys 20 25 30 Ala Met His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Cys Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Leu Asp Val 100 105 110 Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2699 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2699 ggattcacct ttgatgattg tgcc 24 <210> 2700 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2700 Gly Phe Thr Phe Asp Asp Cys Ala 1 5 <210> 2701 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2701 attagttgga atagtggtaa cata 24 <210> 2702 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2702 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 2703 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2703 gcaaaagata tagcagcagc tggtctgtat tactacggtt tggacgtc 48 <210> 2704 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2704 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 2705 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2705 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct ggtccagtca ggacattaac agttatttag tctggtatca gcaaaagcca 120 gggaaagccc ctaaactcct gatctatgct gcatccactt tgctcagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagag ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacac cttaatggtt acccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2706 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2706 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ser Ser Gln Asp Ile Asn Ser Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Leu Asn Gly Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2707 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2707 caggacatta acagttat 18 <210> 2708 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2708 Gln Asp Ile Asn Ser Tyr 1 5 <210> 2709 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2709 gctgcatcc 9 <210> 2710 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2710 Ala Ala Ser 1 <210> 2711 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2711 caacacctta atggttaccc gctcact 27 <210> 2712 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2712 Gln His Leu Asn Gly Tyr Pro Leu Thr 1 5 <210> 2713 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2713 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttattatt ggagttggat ccggcagccc 120 ccagggaagg gactggaatg gattggatat atctattaca gtgggaggac caactacaac 180 ccctccgtca agagtcgagt caccatatca gtagacacgt ccaaaaacca gttctccctg 240 aagctgaact ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatccccag 300 tattactctg agagaagtgg ttattacggg ggttttgact actggggcca gggagcactg 360 gtcaccgtct cctca 375 <210> 2714 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2714 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Val Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Gln Tyr Tyr Ser Glu Arg Ser Gly Tyr Tyr Gly Gly Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 115 120 125 <210> 2715 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2715 ggtggctcca tcagtagtta ttat 24 <210> 2716 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2716 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 2717 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2717 atctattaca gtgggaggac c 21 <210> 2718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2718 Ile Tyr Tyr Ser Gly Arg Thr 1 5 <210> 2719 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2719 gcgagagatc cccagtatta ctctgagaga agtggttatt acgggggttt tgactac 57 <210> 2720 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2720 Ala Arg Asp Pro Gln Tyr Tyr Ser Glu Arg Ser Gly Tyr Tyr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2721 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2721 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca ggtccagcca gagtgttttg ttcagctcca acaattggaa ctatttagct 120 tggtaccagc agaagccagg acagcctcct aagttgctca tttactgggc atctatccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 ccgtacactt ttggccaggg gaccaaggtg gagatcaaac ga 342 <210> 2722 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2722 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Phe Ser 20 25 30 Ser Asn Asn Trp Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 2723 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2723 cagagtgttt tgttcagctc caacaattgg aactat 36 <210> 2724 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2724 Gln Ser Val Leu Phe Ser Ser Asn Asn Trp Asn Tyr 1 5 10 <210> 2725 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2725 tgggcatct 9 <210> 2726 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2726 Trp Ala Ser 1 <210> 2727 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2727 cagcaatatt ataatactcc gtacact 27 <210> 2728 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2728 Gln Gln Tyr Tyr Asn Thr Pro Tyr Thr 1 5 <210> 2729 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2729 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc 120 ccagagaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aaactgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag agatacccag 300 tattactttg atagtagtgg ttattacggg ggttttgact actggggcca gggaaccctg 360 gtcaccgtct cctca 375 <210> 2730 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2730 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Glu Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Thr Gln Tyr Tyr Phe Asp Ser Ser Gly Tyr Tyr Gly Gly Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2731 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2731 ggtggctcca tcagtagtta ctac 24 <210> 2732 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2732 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 2733 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2733 atctattaca gtgggagcac c 21 <210> 2734 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2734 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 2735 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2735 gcgagagata cccagtatta ctttgatagt agtggttatt acgggggttt tgactac 57 <210> 2736 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2736 Ala Arg Asp Thr Gln Tyr Tyr Phe Asp Ser Ser Gly Tyr Tyr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2737 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2737 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gagtgtttta tacagatcca acaataagaa ctacttagct 120 tggtaccacc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca atttattact gtcaacaata ttataatact 300 ccgtacactt ttggccaggg gaccaaggtg gagatcaaac ga 342 <210> 2738 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2738 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr His Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 2739 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2739 cagagtgttt tatacagatc caacaataag aactac 36 <210> 2740 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2740 Gln Ser Val Leu Tyr Arg Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 2741 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2741 tgggcatct 9 <210> 2742 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2742 Trp Ala Ser 1 <210> 2743 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2743 caacaatatt ataatactcc gtacact 27 <210> 2744 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2744 Gln Gln Tyr Tyr Asn Thr Pro Tyr Thr 1 5 <210> 2745 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2745 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aactactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatccag gtgactctga gaccagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gtagcctgaa ggcctcggac accgccttat tttactgtgc gagacttggg 300 aggttcttcg acaactacta cgctatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2746 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2746 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2747 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2747 ggatacacct ttaccaacta ctgg 24 <210> 2748 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2748 Gly Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 2749 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2749 atctatccag gtgactctga gacc 24 <210> 2750 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2750 Ile Tyr Pro Gly Asp Ser Glu Thr 1 5 <210> 2751 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2751 gcgagacttg ggaggttctt cgacaactac tacgctatgg acgtc 45 <210> 2752 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2752 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val 1 5 10 15 <210> 2753 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2753 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcgtccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaattt 240 gcagattttg aaaattacta ctgtcaacag acttacagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2754 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2754 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Phe 65 70 75 80 Ala Asp Phe Glu Asn Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2755 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2755 cagagcatta gcacctat 18 <210> 2756 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2756 Gln Ser Ile Ser Thr Tyr 1 5 <210> 2757 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2757 ggtgcgtcc 9 <210> 2758 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2758 Gly Ala Ser 1 <210> 2759 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2759 caacagactt acagtatccc gtacact 27 <210> 2760 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2760 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2761 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2761 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt gactatggca tgcactgggt ccggcaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atttggtatg atggaaataa aaaagactgt 180 gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat 240 ctacaaatga atagcctgag agccgaggac acggctgtgt attactgtgc gagaatgagg 300 tataactgga actcatttga ctactggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 2762 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2762 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Asn Lys Lys Asp Cys Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Met Arg Tyr Asn Trp Asn Ser Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 2763 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2763 ggattcacct tcagtgacta tggc 24 <210> 2764 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2764 Gly Phe Thr Phe Ser Asp Tyr Gly 1 5 <210> 2765 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2765 atttggtatg atggaaataa aaaa 24 <210> 2766 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2766 Ile Trp Tyr Asp Gly Asn Lys Lys 1 5 <210> 2767 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2767 gcgagaatga ggtataactg gaactcattt gactac 36 <210> 2768 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2768 Ala Arg Met Arg Tyr Asn Trp Asn Ser Phe Asp Tyr 1 5 10 <210> 2769 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2769 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggtcactcac aactatttaa attggtatca gcagaaacca 120 gggaaatccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacag tatgttaatt tccctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2770 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2770 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Val Thr His Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Tyr Val Asn Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2771 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2771 caggtcactc acaactat 18 <210> 2772 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2772 Gln Val Thr His Asn Tyr 1 5 <210> 2773 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2773 gatgcatcc 9 <210> 2774 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2774 Asp Ala Ser 1 <210> 2775 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2775 caacagtatg ttaatttccc tctcact 27 <210> 2776 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2776 Gln Gln Tyr Val Asn Phe Pro Leu Thr 1 5 <210> 2777 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2777 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt gactatggca tgcactgggt ccggcaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atttggtatg atggatataa aaaagactgt 180 atagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctatat 240 ctacaaatga atagcctgag agccgaggac acggcttttt attactgtgc gagaatgagg 300 tataactgga acgcgtttga cttctggggc cagggaacca tggtcaccgt ctcctca 357 <210> 2778 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2778 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Tyr Lys Lys Asp Cys Ile Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Tyr Tyr Cys 85 90 95 Ala Arg Met Arg Tyr Asn Trp Asn Ala Phe Asp Phe Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 2779 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2779 ggattcacct tcagtgacta tggc 24 <210> 2780 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2780 Gly Phe Thr Phe Ser Asp Tyr Gly 1 5 <210> 2781 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2781 atttggtatg atggatataa aaaa 24 <210> 2782 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2782 Ile Trp Tyr Asp Gly Tyr Lys Lys 1 5 <210> 2783 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2783 gcgagaatga ggtataactg gaacgcgttt gacttc 36 <210> 2784 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2784 Ala Arg Met Arg Tyr Asn Trp Asn Ala Phe Asp Phe 1 5 10 <210> 2785 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2785 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacactcac aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacag tatgttaatt tccctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 2786 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2786 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Thr His Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Tyr Val Asn Phe Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2787 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2787 caggacactc acaactat 18 <210> 2788 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2788 Gln Asp Thr His Asn Tyr 1 5 <210> 2789 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2789 gatgcatcc 9 <210> 2790 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2790 Asp Ala Ser 1 <210> 2791 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2791 caacagtatg ttaatttccc tctcact 27 <210> 2792 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2792 Gln Gln Tyr Val Asn Phe Pro Leu Thr 1 5 <210> 2793 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2793 caggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aactactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatccag gtgactctga gaccagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccttat tttactgtgc gaaacttggg 300 aggttcttcg acaactacta cgctatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2794 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2794 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Ala Lys Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2795 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2795 ggatacacct ttaccaacta ctgg 24 <210> 2796 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2796 Gly Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 2797 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2797 atctatccag gtgactctga gacc 24 <210> 2798 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2798 Ile Tyr Pro Gly Asp Ser Glu Thr 1 5 <210> 2799 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2799 gcgaaacttg ggaggttctt cgacaactac tacgctatgg acgtc 45 <210> 2800 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2800 Ala Lys Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val 1 5 10 15 <210> 2801 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2801 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatggt gcgtccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaattt 240 gcagattttg aaaattacta ctgtcaacag acttacagta tcccgtacac ttttggccag 300 gggaccaagc tggagatcaa acga 324 <210> 2802 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2802 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Phe 65 70 75 80 Ala Asp Phe Glu Asn Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 2803 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2803 cagagcatta gcacctat 18 <210> 2804 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2804 Gln Ser Ile Ser Thr Tyr 1 5 <210> 2805 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2805 ggtgcgtcc 9 <210> 2806 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2806 Gly Ala Ser 1 <210> 2807 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2807 caacagactt acagtatccc gtacact 27 <210> 2808 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2808 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2809 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2809 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aactactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatccag gtgactctga gaccagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccttat tttactgtgc gagacttggg 300 aggttcttcg acaactacta cgctatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 2810 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2810 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Leu Phe Tyr Cys 85 90 95 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2811 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2811 ggatacacct ttaccaacta ctgg 24 <210> 2812 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2812 Gly Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 2813 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2813 atctatccag gtgactctga gacc 24 <210> 2814 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2814 Ile Tyr Pro Gly Asp Ser Glu Thr 1 5 <210> 2815 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2815 gcgagacttg ggaggttctt cgacaactac tacgctatgg acgtc 45 <210> 2816 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2816 Ala Arg Leu Gly Arg Phe Phe Asp Asn Tyr Tyr Ala Met Asp Val 1 5 10 15 <210> 2817 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2817 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcatt 60 atcacttgtc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcgtccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaattt 240 gcagattttg aaaattacta ctgtcaacag acttacagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2818 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2818 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Phe 65 70 75 80 Ala Asp Phe Glu Asn Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2819 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2819 cagagcatta gcacctat 18 <210> 2820 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2820 Gln Ser Ile Ser Thr Tyr 1 5 <210> 2821 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2821 ggtgcgtcc 9 <210> 2822 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2822 Gly Ala Ser 1 <210> 2823 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2823 caacagactt acagtatccc gtacact 27 <210> 2824 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2824 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2825 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2825 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct 120 cccggcaagg ggctggaatg ggtggcactt atatggtttg atggaagtaa taaaaactat 180 gcagactccg tgacgggccg attcaccatc tccagagaca attccaagaa tacgctgtat 240 ctgcaaatga acaggctgag agccgaggac acggctgtat actactgtgc gacagaaata 300 gcagctcgtc cctttgaata ttggggccag ggaatcctgg tcaccgtctc ctca 354 <210> 2826 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2826 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Phe Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Ile 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2827 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2827 ggattcacct tcagtaacta tggc 24 <210> 2828 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2828 Gly Phe Thr Phe Ser Asn Tyr Gly 1 5 <210> 2829 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2829 atatggtttg atggaagtaa taaa 24 <210> 2830 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2830 Ile Trp Phe Asp Gly Ser Asn Lys 1 5 <210> 2831 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2831 gcgacagaaa tagcagctcg tccctttgaa tat 33 <210> 2832 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2832 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 2833 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2833 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2834 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2834 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2835 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2835 cagagcctcc tgcatagtaa tggatacaac tat 33 <210> 2836 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2836 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 2837 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2837 ttgggttct 9 <210> 2838 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2838 Leu Gly Ser 1 <210> 2839 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2839 atgcaagctc tacaaactcc gtacact 27 <210> 2840 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2840 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 2841 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2841 caggtgcagc tggtggagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60 acctgtgcca tctccgggga cagtgtctct aggatcaatg ttgcttggaa ctggatcagg 120 cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc cacgtggttt 180 aatgattatg cagtatctgt gaaaagtcga ataaccatca ctcccgacac atccaagaac 240 cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtcta ttactgtaca 300 agagctggaa ctacgtttta ctggtacttc gatctctggg gccgtggcac cctggtcacc 360 gtctcctca 369 <210> 2842 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2842 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Arg Ile 20 25 30 Asn Val Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Thr Trp Phe Asn Asp Tyr Ala 50 55 60 Val Ser Val Lys Ser Arg Ile Thr Ile Thr Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Thr Arg Ala Gly Thr Thr Phe Tyr Trp Tyr Phe Asp Leu 100 105 110 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2843 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2843 ggggacagtg tctctaggat caatgttgct 30 <210> 2844 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2844 Gly Asp Ser Val Ser Arg Ile Asn Val Ala 1 5 10 <210> 2845 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2845 acatactaca ggtccacgtg gtttaat 27 <210> 2846 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2846 Thr Tyr Tyr Arg Ser Thr Trp Phe Asn 1 5 <210> 2847 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2847 acaagagctg gaactacgtt ttactggtac ttcgatctc 39 <210> 2848 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2848 Thr Arg Ala Gly Thr Thr Phe Tyr Trp Tyr Phe Asp Leu 1 5 10 <210> 2849 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2849 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gggtattggt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattgtg caacttatta ctgccaacag tatgatactt attacacttt tggccagggg 300 accaaggtgg agatcaaacg a 321 <210> 2850 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2850 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Cys Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Thr Tyr Tyr Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2851 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2851 cagggtattg gtagctgg 18 <210> 2852 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2852 Gln Gly Ile Gly Ser Trp 1 5 <210> 2853 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2853 aaggcgtct 9 <210> 2854 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2854 Lys Ala Ser 1 <210> 2855 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2855 caacagtatg atacttatta cact 24 <210> 2856 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2856 Gln Gln Tyr Asp Thr Tyr Tyr Thr 1 5 <210> 2857 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2857 caggtgcagc tggtggagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60 acctgtgcca tctccgggga cagtgtctct aggatcaatg ttgcttggaa ctggatcagg 120 cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc cacgtggttt 180 aatgattatg cagtgtctgt gaaaagtcga ataaccatca ctcccgacac atccaagaac 240 cagttctccc tgcaactgaa ctctgtgact cccgaggaca cggctgtcta ttactgtaca 300 agagctggaa ctacgtttta ctggtacttc gatctctggg gccgtggcac cctggtcacc 360 gtctcctca 369 <210> 2858 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2858 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Arg Ile 20 25 30 Asn Val Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 35 40 45 Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Thr Trp Phe Asn Asp Tyr Ala 50 55 60 Val Ser Val Lys Ser Arg Ile Thr Ile Thr Pro Asp Thr Ser Lys Asn 65 70 75 80 Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Thr Arg Ala Gly Thr Thr Phe Tyr Trp Tyr Phe Asp Leu 100 105 110 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2859 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2859 ggggacagtg tctctaggat caatgttgct 30 <210> 2860 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2860 Gly Asp Ser Val Ser Arg Ile Asn Val Ala 1 5 10 <210> 2861 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2861 acatactaca ggtccacgtg gtttaat 27 <210> 2862 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2862 Thr Tyr Tyr Arg Ser Thr Trp Phe Asn 1 5 <210> 2863 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2863 acaagagctg gaactacgtt ttactggtac ttcgatctc 39 <210> 2864 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2864 Thr Arg Ala Gly Thr Thr Phe Tyr Trp Tyr Phe Asp Leu 1 5 10 <210> 2865 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2865 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gggtattggt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattgtg catcttatta ctgccaacag tatgatactt attacacttt tggccagggg 300 accaaggtgg agatcaaacg a 321 <210> 2866 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2866 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Cys Ala Ser Tyr Tyr Cys Gln Gln Tyr Asp Thr Tyr Tyr Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2867 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2867 cagggtattg gtagctgg 18 <210> 2868 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2868 Gln Gly Ile Gly Ser Trp 1 5 <210> 2869 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2869 aaggcgtct 9 <210> 2870 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2870 Lys Ala Ser 1 <210> 2871 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2871 caacagtatg atacttatta cact 24 <210> 2872 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2872 Gln Gln Tyr Asp Thr Tyr Tyr Thr 1 5 <210> 2873 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2873 gaggtgcagc tggtggagtc tggagcagag gtcaagaagc ccggggagtc tctgaagatc 60 tcctgtaagg tttctggata cagttttacc aactactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatccta gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccaatag caccgcctac 240 ctacagtgga ccagcctgaa ggccgcggac accgccatgt atttctgtgc gaggtcggca 300 aatttttgga gtggttatcc ctttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 2874 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2874 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Asn Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Thr Ser Leu Lys Ala Ala Asp Thr Ala Met Tyr Phe Cys 85 90 95 Ala Arg Ser Ala Asn Phe Trp Ser Gly Tyr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2875 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2875 ggatacagtt ttaccaacta ctgg 24 <210> 2876 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2876 Gly Tyr Ser Phe Thr Asn Tyr Trp 1 5 <210> 2877 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2877 atctatccta gtgactctga tacc 24 <210> 2878 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2878 Ile Tyr Pro Ser Asp Ser Asp Thr 1 5 <210> 2879 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2879 gcgaggtcgg caaatttttg gagtggttat ccctttgact ac 42 <210> 2880 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2880 Ala Arg Ser Ala Asn Phe Trp Ser Gly Tyr Pro Phe Asp Tyr 1 5 10 <210> 2881 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2881 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt agatatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc cgggacagat ttcactctca ccatcaacag tctgcaacct 240 gaagattttg caacttacta ttgtcaacag acttacagta tcccgtacac atttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2882 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2882 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2883 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2883 cagagcatta gtagatat 18 <210> 2884 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2884 Gln Ser Ile Ser Arg Tyr 1 5 <210> 2885 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2885 gttgcatcc 9 <210> 2886 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2886 Val Ala Ser 1 <210> 2887 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2887 caacagactt acagtatccc gtacaca 27 <210> 2888 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2888 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2889 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2889 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctatggca tgcattgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggccctt atatggtatg acggaactaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 2890 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2890 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Thr Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2891 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2891 ggattcacct tcagtaccta tggc 24 <210> 2892 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2892 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 2893 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2893 atatggtatg acggaactaa taaa 24 <210> 2894 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2894 Ile Trp Tyr Asp Gly Thr Asn Lys 1 5 <210> 2895 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2895 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 2896 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2896 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 2897 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2897 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagcctccta cagattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2898 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2898 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2899 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2899 cagagcctcc tacagattaa tggatacaac tat 33 <210> 2900 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2900 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 2901 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2901 ttgggttct 9 <210> 2902 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2902 Leu Gly Ser 1 <210> 2903 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2903 atgcaagctc ttcaaactcc gtacact 27 <210> 2904 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2904 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 2905 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2905 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgtag cgtctggaat caccttcagt aactatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atatggtatg atggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcatcatc tccagagaca attccaagaa tacgctgtat 240 ctgcaaatga acagcctgag agccgaggac gcggctgtgt acttctgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 2906 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2906 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Phe Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2907 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2907 ggaatcacct tcagtaacta tggc 24 <210> 2908 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2908 Gly Ile Thr Phe Ser Asn Tyr Gly 1 5 <210> 2909 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2909 atatggtatg atggaagtaa taaa 24 <210> 2910 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2910 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 2911 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2911 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 2912 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2912 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 2913 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2913 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctgggga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg caaattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2914 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2914 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2915 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2915 cagagcctcc tgcaaattaa tggatacaac tat 33 <210> 2916 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2916 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 2917 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2917 ttgggttct 9 <210> 2918 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2918 Leu Gly Ser 1 <210> 2919 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2919 atgcaagctc tacaaactcc gtacact 27 <210> 2920 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2920 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 2921 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2921 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatgata tgcactgggt ccgccaggct 120 ccagggaagg gactggaata tgtttcaggt attagtagta aggggggtag cacatattat 180 gcagactctg tgaagggcag attcaccatc tccagagaca attccaagaa tatactgtat 240 cttcaaatgg gcagactgag acctgaggac atggctgtgt attactgtgc gagagaggga 300 caactttggt actttgacta ctggggccag ggaaccatgg tcaccgtctc ctca 354 <210> 2922 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2922 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Ser Gly Ile Ser Ser Lys Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ile Leu Tyr 65 70 75 80 Leu Gln Met Gly Arg Leu Arg Pro Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gln Leu Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 2923 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2923 ggattcacct tcagtagcta tgat 24 <210> 2924 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2924 Gly Phe Thr Phe Ser Ser Tyr Asp 1 5 <210> 2925 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2925 attagtagta aggggggtag caca 24 <210> 2926 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2926 Ile Ser Ser Lys Gly Gly Ser Thr 1 5 <210> 2927 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2927 gcgagagagg gacaactttg gtactttgac tac 33 <210> 2928 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2928 Ala Arg Glu Gly Gln Leu Trp Tyr Phe Asp Tyr 1 5 10 <210> 2929 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2929 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagt agctacttag cctggtacca acagaaacct 120 ggccaggctc ccagactcct catctatgct gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgttccaact ggcctctcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 2930 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2930 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2931 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2931 cagagtgtta gtagctac 18 <210> 2932 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2932 Gln Ser Val Ser Ser Tyr 1 5 <210> 2933 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2933 gctgcatcc 9 <210> 2934 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2934 Ala Ala Ser 1 <210> 2935 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2935 cagcagcgtt ccaactggcc tctcact 27 <210> 2936 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2936 Gln Gln Arg Ser Asn Trp Pro Leu Thr 1 5 <210> 2937 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2937 caggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggagagtc tctgaagatc 60 tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt tttactgtgc gaggtcggaa 300 gatttttgga gtgcttatcc ctttgactac tggggccagg gaaccatggt caccgtctcc 360 tca 363 <210> 2938 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2938 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Phe Tyr Cys 85 90 95 Ala Arg Ser Glu Asp Phe Trp Ser Ala Tyr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2939 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2939 ggatacagct ttaccagcta ctgg 24 <210> 2940 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2940 Gly Tyr Ser Phe Thr Ser Tyr Trp 1 5 <210> 2941 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2941 atctatcctg gtgactctga tacc 24 <210> 2942 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2942 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 2943 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2943 gcgaggtcgg aagatttttg gagtgcttat ccctttgact ac 42 <210> 2944 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2944 Ala Arg Ser Glu Asp Phe Trp Ser Ala Tyr Pro Phe Asp Tyr 1 5 10 <210> 2945 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2945 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagaatcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctgagctcct gatctatgct gcttccagtt tgcagagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaatattttg caacttacta ctgtcaacag agttacagta ttccgtatac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 2946 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2946 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Tyr Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 2947 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2947 cagagcatta gcagctat 18 <210> 2948 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2948 Gln Ser Ile Ser Ser Tyr 1 5 <210> 2949 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2949 gctgcttcc 9 <210> 2950 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2950 Ala Ala Ser 1 <210> 2951 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2951 caacagagtt acagtattcc gtatact 27 <210> 2952 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2952 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 2953 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2953 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctatggca tgcattgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggccctt atatggtatg acggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 2954 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2954 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2955 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2955 ggattcacct tcagtaccta tggc 24 <210> 2956 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2956 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 2957 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2957 atatggtatg acggaagtaa taaa 24 <210> 2958 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2958 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 2959 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2959 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 2960 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2960 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 2961 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2961 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagtctccta caaattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2962 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2962 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2963 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2963 cagagtctcc tacaaattaa tggatacaac tat 33 <210> 2964 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2964 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 2965 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2965 ttgggttct 9 <210> 2966 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2966 Leu Gly Ser 1 <210> 2967 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2967 atgcaagctc ttcaaactcc gtacact 27 <210> 2968 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2968 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 2969 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2969 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt tcctatggca tgcattgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggccctt atatggtatg acggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 2970 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2970 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2971 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2971 ggattcacct tcagttccta tggc 24 <210> 2972 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2972 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 2973 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2973 atatggtatg acggaagtaa taaa 24 <210> 2974 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2974 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 2975 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2975 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 2976 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2976 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 2977 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2977 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagcctccta cagattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2978 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2978 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2979 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2979 cagagcctcc tacagattaa tggatacaac tat 33 <210> 2980 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2980 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 2981 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2981 ttgggttct 9 <210> 2982 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2982 Leu Gly Ser 1 <210> 2983 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2983 atgcaagctc ttcaaactcc gtacact 27 <210> 2984 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2984 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 2985 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2985 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt tcctatggca tgcattgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggccctt atatggtatg acggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 2986 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2986 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 2987 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2987 ggattcacct tcagttccta tggc 24 <210> 2988 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2988 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 2989 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2989 atatggtatg acggaagtaa taaa 24 <210> 2990 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2990 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 2991 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2991 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 2992 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2992 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 2993 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2993 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagcctccta cagattaatg gatacaacta tttggattgg 120 tacttgcaga agccagggca gtctccacac ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg agcctgatga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 2994 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2994 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro His Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Pro Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 2995 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2995 cagagcctcc tacagattaa tggatacaac tat 33 <210> 2996 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2996 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 2997 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2997 ttgggttct 9 <210> 2998 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 2998 Leu Gly Ser 1 <210> 2999 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 2999 atgcaagctc ttcaaactcc gtacact 27 <210> 3000 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3000 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 3001 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3001 gaggtgcagc tggtggagtc tgggggaggc ttggttcagc cgggggggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttagc atttatggca tgagttgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct tttagtggtc gtggtggtac ttcatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca aatccaagaa cacgctgtat 240 ctggaaatga tgagcctgag agccgaggac acggccgtat attactgtgc gaatgatgat 300 ttggattact ttggttcggg agtcaggaac tactaccact acggtatgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 3002 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3002 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ile Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Phe Ser Gly Arg Gly Gly Thr Ser Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Glu Met Met Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asn Asp Asp Leu Asp Tyr Phe Gly Ser Gly Val Arg Asn Tyr Tyr 100 105 110 His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 3003 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3003 ggattcacct ttagcattta tggc 24 <210> 3004 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3004 Gly Phe Thr Phe Ser Ile Tyr Gly 1 5 <210> 3005 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3005 tttagtggtc gtggtggtac ttca 24 <210> 3006 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3006 Phe Ser Gly Arg Gly Gly Thr Ser 1 5 <210> 3007 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3007 gcgaatgatg atttggatta c 21 <210> 3008 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3008 Ala Asn Asp Asp Leu Asp Tyr 1 5 <210> 3009 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3009 gacatccaga tgacccagtc tccaccctcc ctgtctgtct ctcctggaga gagagccacc 60 atctcctgca gggctagtca gagcattaac aactatttag actggtacca gcagaaacca 120 gggcaggctc caaagctcct gatctatgct gcatccaatc gggccactgg ggtcccagcc 180 aggttcagtg gcagtggatc tgggacagat ttcactctca cgatcagcag cctgcaggct 240 gaagattttg cagtttatta ctgtctgcaa gctaatcaat ctccgttcac tttcggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3010 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3010 Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Ile Asn Asn Tyr 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Ala Asn Gln Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3011 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3011 cagagcatta acaactat 18 <210> 3012 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3012 Gln Ser Ile Asn Asn Tyr 1 5 <210> 3013 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3013 gctgcatcc 9 <210> 3014 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3014 Ala Ala Ser 1 <210> 3015 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3015 ctgcaagcta atcaatctcc gttcact 27 <210> 3016 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3016 Leu Gln Ala Asn Gln Ser Pro Phe Thr 1 5 <210> 3017 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3017 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctatggca tgcattgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggccctt atatggtatg acggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 3018 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3018 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 3019 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3019 ggattcacct tcagtaccta tggc 24 <210> 3020 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3020 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 3021 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3021 atatggtatg acggaagtaa taaa 24 <210> 3022 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3022 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 3023 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3023 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 3024 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3024 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 3025 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3025 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagtctccta caaattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 3026 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3026 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 3027 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3027 cagagtctcc tacaaattaa tggatacaac tat 33 <210> 3028 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3028 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 3029 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3029 ttgggttct 9 <210> 3030 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3030 Leu Gly Ser 1 <210> 3031 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3031 atgcaagctc ttcaaactcc gtacact 27 <210> 3032 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3032 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 3033 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3033 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt tcctatggca tgcattgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggccctt atatggtttg acggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 3034 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3034 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Phe Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 3035 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3035 ggattcacct tcagttccta tggc 24 <210> 3036 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3036 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 3037 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3037 atatggtttg acggaagtaa taaa 24 <210> 3038 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3038 Ile Trp Phe Asp Gly Ser Asn Lys 1 5 <210> 3039 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3039 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 3040 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3040 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 3041 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3041 gacatcgtga tgacccagtc tccactctcc ctgtccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagcctccta cagattaatg gatataacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 3042 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3042 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 3043 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3043 cagagcctcc tacagattaa tggatataac tat 33 <210> 3044 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3044 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 3045 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3045 ttgggttct 9 <210> 3046 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3046 Leu Gly Ser 1 <210> 3047 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3047 atgcaagctc ttcaaactcc gtacact 27 <210> 3048 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3048 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 3049 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3049 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatgata tgcactgggt ccgccaggct 120 ccagggaagg gactggaata tgtttcaggt attagtagta aggggggtag cacatattat 180 gcagactctg tgaagggcag attcaccatc tccagagaca attccaagaa tatactgtat 240 cttcaaatgg gcagactgag acctgaggac atggctgtgt attactgtgc gagagaggga 300 caactttggt actttgacta ctggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 3050 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3050 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Ser Gly Ile Ser Ser Lys Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ile Leu Tyr 65 70 75 80 Leu Gln Met Gly Arg Leu Arg Pro Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gln Leu Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 3051 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3051 ggattcacct tcagtagcta tgat 24 <210> 3052 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3052 Gly Phe Thr Phe Ser Ser Tyr Asp 1 5 <210> 3053 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3053 attagtagta aggggggtag caca 24 <210> 3054 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3054 Ile Ser Ser Lys Gly Gly Ser Thr 1 5 <210> 3055 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3055 gcgagagagg gacaactttg gtactttgac tac 33 <210> 3056 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3056 Ala Arg Glu Gly Gln Leu Trp Tyr Phe Asp Tyr 1 5 10 <210> 3057 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3057 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagt agctacttag cctggtacca acagaaacct 120 ggccaggctc ccagactcct catctatgct gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgttccaact ggcctctcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3058 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3058 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3059 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3059 cagagtgtta gtagctac 18 <210> 3060 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3060 Gln Ser Val Ser Ser Tyr 1 5 <210> 3061 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3061 gctgcatcc 9 <210> 3062 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3062 Ala Ala Ser 1 <210> 3063 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3063 cagcagcgtt ccaactggcc tctcact 27 <210> 3064 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3064 Gln Gln Arg Ser Asn Trp Pro Leu Thr 1 5 <210> 3065 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3065 caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt catcttcagt agctatgata tgcactgggt ccgccaggct 120 ccagggaagg gactggaata tgtttcaggt attagtacta aggggggaag tacatattat 180 gcagactctg tgaaggacag attcaccatc tccagagaca attccaagaa cacgctatat 240 cttcaaatgg gcagcctgag agctgaggac atggctgtat attactgtgc gagagaggga 300 caactttggt actttgacta ctggggccag ggaaccacgg tcaccgtctc ctca 354 <210> 3066 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3066 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Ser Gly Ile Ser Thr Lys Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gln Leu Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 3067 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3067 ggattcatct tcagtagcta tgat 24 <210> 3068 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3068 Gly Phe Ile Phe Ser Ser Tyr Asp 1 5 <210> 3069 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3069 attagtacta aggggggaag taca 24 <210> 3070 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3070 Ile Ser Thr Lys Gly Gly Ser Thr 1 5 <210> 3071 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3071 gcgagagagg gacaactttg gtactttgac tac 33 <210> 3072 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3072 Ala Arg Glu Gly Gln Leu Trp Tyr Phe Asp Tyr 1 5 10 <210> 3073 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3073 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gactgttaga agctacttag cctggtacca acagaaacct 120 ggccaggctc ccagactcct catctatact gcatctaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcatcctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgttccaact ggcctctcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3074 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3074 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Arg Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3075 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3075 cagactgtta gaagctac 18 <210> 3076 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3076 Gln Thr Val Arg Ser Tyr 1 5 <210> 3077 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3077 actgcatct 9 <210> 3078 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3078 Thr Ala Ser 1 <210> 3079 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3079 cagcagcgtt ccaactggcc tctcact 27 <210> 3080 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3080 Gln Gln Arg Ser Asn Trp Pro Leu Thr 1 5 <210> 3081 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3081 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctatggca tgcattgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggccctt atatggtatg acggaagtaa taaaaactat 180 gcagattccg tgacgggccg attcaccatc tccagagaca attccaagaa cacattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gacagaaata 300 gcagctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 3082 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3082 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 3083 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3083 ggattcacct tcagtaccta tggc 24 <210> 3084 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3084 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 3085 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3085 atatggtatg acggaagtaa taaa 24 <210> 3086 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3086 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 3087 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3087 gcgacagaaa tagcagctcg tccctttgaa tac 33 <210> 3088 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3088 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 3089 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3089 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtctactca gagtctccta caaattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actaaagatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 3090 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3090 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 3091 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3091 cagagtctcc tacaaattaa tggatacaac tat 33 <210> 3092 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3092 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 3093 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3093 ttgggttct 9 <210> 3094 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3094 Leu Gly Ser 1 <210> 3095 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3095 atgcaagctc ttcaaactcc gtacact 27 <210> 3096 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3096 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 3097 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3097 caggtgcagc tggtggagtc tgaaacagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cagctttacc aactactgga tcggctgggt gcgccagatg 120 cccggaaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagaaac 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agaccatcag caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gaggtcggca 300 gatttttgga gtggttatcc ctttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 3098 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3098 Gln Val Gln Leu Val Glu Ser Glu Thr Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Asn Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Thr Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Ser Ala Asp Phe Trp Ser Gly Tyr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3099 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3099 ggatacagct ttaccaacta ctgg 24 <210> 3100 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3100 Gly Tyr Ser Phe Thr Asn Tyr Trp 1 5 <210> 3101 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3101 atctatcctg gtgactctga tacc 24 <210> 3102 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3102 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 3103 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3103 gcgaggtcgg cagatttttg gagtggttat ccctttgact ac 42 <210> 3104 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3104 Ala Arg Ser Ala Asp Phe Trp Ser Gly Tyr Pro Phe Asp Tyr 1 5 10 <210> 3105 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3105 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagactcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca acatcagcag tctgcaacct 240 gaagattttt caacttacta ttgtcaacag acctacagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3106 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3106 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Leu Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ser Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3107 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3107 cagagcatta gcagctat 18 <210> 3108 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3108 Gln Ser Ile Ser Ser Tyr 1 5 <210> 3109 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3109 gctgcatcc 9 <210> 3110 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3110 Ala Ala Ser 1 <210> 3111 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3111 caacagacct acagtatccc gtacact 27 <210> 3112 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3112 Gln Gln Thr Tyr Ser Ile Pro Tyr Thr 1 5 <210> 3113 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3113 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt tcctatggca tgcattgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggccctt atatggtatg acggaagtaa taaaaactat 180 gcagattccg tgatgggccg attcaccatc tccagagaca attccaggag cacattgttt 240 ctgcaaatga acagcctgag agccgaggac acggctcttt attactgtgc gacagaaata 300 gcatctcgtc cctttgaata ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 3114 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3114 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Ser Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ser Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 3115 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3115 ggattcacct tcagttccta tggc 24 <210> 3116 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3116 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 3117 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3117 atatggtatg acggaagtaa taaa 24 <210> 3118 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3118 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 3119 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3119 gcgacagaaa tagcatctcg tccctttgaa tac 33 <210> 3120 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3120 Ala Thr Glu Ile Ala Ser Arg Pro Phe Glu Tyr 1 5 10 <210> 3121 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3121 gacatcgtga tgacccagtc tccactctcc ctgcccgtca ctcctggaga gccggcctcc 60 atctcctgca ggtcttctca gagcctccta cagattaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggagcaggca cagattttac actgaagatc 240 agcagagtgg aggctgagga tattgggatt tattactgca tgcaagctct tcaaactccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 3122 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3122 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln Ile 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Ile Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 3123 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3123 cagagcctcc tacagattaa tggatacaac tat 33 <210> 3124 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3124 Gln Ser Leu Leu Gln Ile Asn Gly Tyr Asn Tyr 1 5 10 <210> 3125 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3125 ttgggttct 9 <210> 3126 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3126 Leu Gly Ser 1 <210> 3127 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3127 atgcaagctc ttcaaactcc gtacact 27 <210> 3128 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3128 Met Gln Ala Leu Gln Thr Pro Tyr Thr 1 5 <210> 3129 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3129 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgttg tctatggtgg gtccttaagt ggttactact ggagcttgat ccgccagtcc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtggacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc cgcggacacg gctttgtatt actgtgcgag aggctctctt 300 ataacagatc gagactggta tttcgatatc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3130 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3130 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Val Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Leu Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Ile Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3131 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3131 ggtgggtcct taagtggtta ctac 24 <210> 3132 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3132 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3133 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3133 atcgatcata ctggaagcac c 21 <210> 3134 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3134 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3135 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3135 gcgagaggct ctcttataac agatcgagac tggtatttcg atatc 45 <210> 3136 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3136 Ala Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Ile 1 5 10 15 <210> 3137 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3137 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagtcacc 60 ctctcctgca gggccagtca gagtgttacc agcaacttag cctggtacca gcagaaacct 120 gcccaggctc ccaggctcct catctatgct gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagaa tacactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcaacac tataataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3138 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3138 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Ala Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3139 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3139 cagagtgtta ccagcaac 18 <210> 3140 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3140 Gln Ser Val Thr Ser Asn 1 5 <210> 3141 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3141 gctgcatcc 9 <210> 3142 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3142 Ala Ala Ser 1 <210> 3143 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3143 caacactata ataactggcc gtacact 27 <210> 3144 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3144 Gln His Tyr Asn Asn Trp Pro Tyr Thr 1 5 <210> 3145 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3145 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatacca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaact attattttta gtggtctttt cacatactac 180 gcggactccg tgaagggccg tttcaccatc tccagagaca attccaagaa caccctcttt 240 ctgcaaatga atagcctggg ggccgaggac acggccatat attactgtgc gaaagcctca 300 gctacaataa ctacgaagga cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 3146 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3146 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ile Phe Ser Gly Leu Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Lys Ala Ser Ala Thr Ile Thr Thr Lys Asp Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3147 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3147 ggattcacct ttagcagcta tacc 24 <210> 3148 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3148 Gly Phe Thr Phe Ser Ser Tyr Thr 1 5 <210> 3149 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3149 attattttta gtggtctttt caca 24 <210> 3150 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3150 Ile Ile Phe Ser Gly Leu Phe Thr 1 5 <210> 3151 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3151 gcgaaagcct cagctacaat aactacgaag gacggtatgg acgtc 45 <210> 3152 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3152 Ala Lys Ala Ser Ala Thr Ile Thr Thr Lys Asp Gly Met Asp Val 1 5 10 15 <210> 3153 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3153 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctctgct gcatccagtt tacaaagtgg ggtcccttca 180 aggttcagcg gcagtggatc tgacacagat ttcactctca ccatcagcag cctgcagact 240 gaagattttg caacttatta ctgtctacaa gatttcaatt tccctcggac attcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 3154 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3154 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Asp Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Thr 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Phe Asn Phe Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3155 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3155 cagggcatta gaaatgat 18 <210> 3156 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3156 Gln Gly Ile Arg Asn Asp 1 5 <210> 3157 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3157 gctgcatcc 9 <210> 3158 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3158 Ala Ala Ser 1 <210> 3159 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3159 ctacaagatt tcaatttccc tcggaca 27 <210> 3160 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3160 Leu Gln Asp Phe Asn Phe Pro Arg Thr 1 5 <210> 3161 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3161 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcagt ggttactatt ggagctggat ccgccagccc 120 ccagggaagg ggctggcgtg gattggggag atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aggctgagtt ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctctcgt 300 ataacagatc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3162 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3162 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Ala Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3163 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3163 ggtgggtccc tcagtggtta ctat 24 <210> 3164 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3164 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3165 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3165 atcgatcata ctggaagcac c 21 <210> 3166 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3166 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3167 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3167 gcgagaggct ctcgtataac agatcgagac tggtacttcg atctc 45 <210> 3168 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3168 Ala Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3169 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3169 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttagt agccacttag cctggtacca ccagaaacct 120 ggccaggctc ccaggctcct cctctattct ggatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcgctctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcaa tataatgact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3170 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3170 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser His 20 25 30 Leu Ala Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Leu 35 40 45 Tyr Ser Gly Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Ala Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3171 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3171 cagagtgtta gtagccac 18 <210> 3172 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3172 Gln Ser Val Ser Ser His 1 5 <210> 3173 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3173 tctggatcc 9 <210> 3174 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3174 Ser Gly Ser 1 <210> 3175 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3175 cagcaatata atgactggcc gtacact 27 <210> 3176 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3176 Gln Gln Tyr Asn Asp Trp Pro Tyr Thr 1 5 <210> 3177 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3177 caggtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc 60 tcctgtacag tttctggact cacctttggt gattatgcta tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca 180 gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc 240 gcctatctgc aaatgaacag cctgaagacc gaggacacag ccgtgtatta ctgtagttcg 300 tccggacctg actactgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 3178 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3178 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Leu Thr Phe Gly Asp Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 50 55 60 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 65 70 75 80 Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ser Ser Ser Gly Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 3179 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3179 ggactcacct ttggtgatta tgct 24 <210> 3180 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3180 Gly Leu Thr Phe Gly Asp Tyr Ala 1 5 <210> 3181 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3181 attagaagca aagcttatgg tgggacaaca 30 <210> 3182 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3182 Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr 1 5 10 <210> 3183 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3183 agttcgtccg gacctgacta c 21 <210> 3184 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3184 Ser Ser Ser Gly Pro Asp Tyr 1 5 <210> 3185 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3185 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag tctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccggtt tgcaaagtgg ggtcccatcg 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa cataatagtt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 3186 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3186 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3187 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3187 cagggcatta gaaatgat 18 <210> 3188 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3188 Gln Gly Ile Arg Asn Asp 1 5 <210> 3189 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3189 gctgcatcc 9 <210> 3190 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3190 Ala Ala Ser 1 <210> 3191 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3191 ctacaacata atagttaccc gtggacg 27 <210> 3192 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3192 Leu Gln His Asn Ser Tyr Pro Trp Thr 1 5 <210> 3193 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3193 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctctggtgg gaccctcagt ccttactatt ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagtac caacttcaat 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aatctgaact ctgtgaccgc cgcggacacg gctatctatt tctgtgcgag aggctctctt 300 ataacatctc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3194 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3194 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Thr Leu Ser Pro Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Phe Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Ser Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3195 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3195 ggtgggaccc tcagtcctta ctat 24 <210> 3196 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3196 Gly Gly Thr Leu Ser Pro Tyr Tyr 1 5 <210> 3197 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3197 atcgatcata ctggaagtac c 21 <210> 3198 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3198 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3199 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3199 gcgagaggct ctcttataac atctcgagac tggtacttcg atctc 45 <210> 3200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3200 Ala Arg Gly Ser Leu Ile Thr Ser Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3201 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3201 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagaggcacc 60 ctctcctgca gggccagtca gagtcttagc agccacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcttccgcca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tatgataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3202 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3202 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Gly Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser His 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ala Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3203 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3203 cagagtctta gcagccac 18 <210> 3204 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3204 Gln Ser Leu Ser Ser His 1 5 <210> 3205 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3205 ggtgcttcc 9 <210> 3206 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3206 Gly Ala Ser 1 <210> 3207 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3207 cagcagtatg ataactggcc gtacact 27 <210> 3208 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3208 Gln Gln Tyr Asp Asn Trp Pro Tyr Thr 1 5 <210> 3209 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3209 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttccgt ggttactact ggaactggat ccgccagccc 120 ccggggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac cacctacaac 180 ccgtccctca agagtcgatt caccatgtca gtggacacgt ccaagaacca gttctccctg 240 attctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aaatgagcta 300 actggagatt gggttgcttt tgatatctgg ggccaaggga caatggtcac cgtctcctca 360 <210> 3210 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3210 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Arg Gly Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Phe Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Ile Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asn Glu Leu Thr Gly Asp Trp Val Ala Phe Asp Ile Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3211 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3211 ggtgggtcct tccgtggtta ctac 24 <210> 3212 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3212 Gly Gly Ser Phe Arg Gly Tyr Tyr 1 5 <210> 3213 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3213 atcaatcata gtggaagcac c 21 <210> 3214 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3214 Ile Asn His Ser Gly Ser Thr 1 5 <210> 3215 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3215 gcgagaaatg agctaactgg agattgggtt gcttttgata tc 42 <210> 3216 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3216 Ala Arg Asn Glu Leu Thr Gly Asp Trp Val Ala Phe Asp Ile 1 5 10 <210> 3217 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3217 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga gagagccacc 60 ctctcctgca gggccagtca gagtgttagc gccagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatcttt ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta tttctgtcag cagtatggta gctcaccgtg gacgttcggc 300 caagggacca aggtggagat caaacga 327 <210> 3218 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3218 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ala Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Phe Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3219 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3219 cagagtgtta gcgccagcta c 21 <210> 3220 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3220 Gln Ser Val Ser Ala Ser Tyr 1 5 <210> 3221 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3221 ggtgcatcc 9 <210> 3222 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3222 Gly Ala Ser 1 <210> 3223 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3223 cagcagtatg gtagctcacc gtggacg 27 <210> 3224 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3224 Gln Gln Tyr Gly Ser Ser Pro Trp Thr 1 5 <210> 3225 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3225 caggtgcagc tggtgcagtg gggcgcagga ctgttgatgc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctgggt ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata gtggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aagggagcta 300 actggggatt ggggtgcttt tgatatctgg ggccaaggga caatggtcac cgtctcctca 360 <210> 3226 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3226 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Met Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Arg Glu Leu Thr Gly Asp Trp Gly Ala Phe Asp Ile Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3227 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3227 ggtgggtcct tcagtggtta ctac 24 <210> 3228 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3228 Gly Gly Ser Phe Ser Gly Tyr Tyr 1 5 <210> 3229 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3229 atcgatcata gtggaagcac c 21 <210> 3230 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3230 Ile Asp His Ser Gly Ser Thr 1 5 <210> 3231 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3231 gcgagaaggg agctaactgg ggattggggt gcttttgata tc 42 <210> 3232 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3232 Ala Arg Arg Glu Leu Thr Gly Asp Trp Gly Ala Phe Asp Ile 1 5 10 <210> 3233 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3233 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc ggcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc 300 caagggacca aggtggagat caaacga 327 <210> 3234 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3234 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3235 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3235 cagagtgtta gcggcagcta c 21 <210> 3236 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3236 Gln Ser Val Ser Gly Ser Tyr 1 5 <210> 3237 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3237 ggtgcatcc 9 <210> 3238 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3238 Gly Ala Ser 1 <210> 3239 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3239 cagcagtatg gtagctcacc gtggacg 27 <210> 3240 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3240 Gln Gln Tyr Gly Ser Ser Pro Trp Thr 1 5 <210> 3241 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3241 gaggtgcagc tggtggagtc tgggggaggc ttggtactgc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttaac agttacgcct tgacctgggt ccgccaggct 120 ccagggaggg ggctggaatg ggtctcaact attattttca gtggtggtat catatggtac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acaccatgag agccgaggac acggccatat attactgtgc gaaagcctca 300 gccactataa cgacaaagga cggtttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 3242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3242 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 20 25 30 Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ile Phe Ser Gly Gly Ile Ile Trp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Thr Met Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Lys Ala Ser Ala Thr Ile Thr Thr Lys Asp Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3243 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3243 ggattcacct ttaacagtta cgcc 24 <210> 3244 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3244 Gly Phe Thr Phe Asn Ser Tyr Ala 1 5 <210> 3245 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3245 attattttca gtggtggtat cata 24 <210> 3246 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3246 Ile Ile Phe Ser Gly Gly Ile Ile 1 5 <210> 3247 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3247 gcgaaagcct cagccactat aacgacaaag gacggtttgg acgtc 45 <210> 3248 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3248 Ala Lys Ala Ser Ala Thr Ile Thr Thr Lys Asp Gly Leu Asp Val 1 5 10 15 <210> 3249 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3249 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcaat 60 atcacttgcc gggcaagtca gggcatcaga aatgatttag gctggtatca gcagagacca 120 gggaaagccc ctacgctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatct 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaggattttg caacttatta ctgtctacag gattacaatt accctcggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 3250 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3250 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Asn Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Thr Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3251 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3251 cagggcatca gaaatgat 18 <210> 3252 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3252 Gln Gly Ile Arg Asn Asp 1 5 <210> 3253 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3253 gctgcatcc 9 <210> 3254 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3254 Ala Ala Ser 1 <210> 3255 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3255 ctacaggatt acaattaccc tcggacg 27 <210> 3256 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3256 Leu Gln Asp Tyr Asn Tyr Pro Arg Thr 1 5 <210> 3257 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3257 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgttg tgtatagtgg atccctcagt ggttactact ggagctggat ccggcagtcc 120 ccagggaagg gactggagtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctcactg 240 aggctgacct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag agggtctcgt 300 ataacagatc gagactggta cttcgatccc tggggccgtg gctccctggt caccgtctcc 360 tca 363 <210> 3258 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3258 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Val Val Tyr Ser Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Pro Trp Gly 100 105 110 Arg Gly Ser Leu Val Thr Val Ser Ser 115 120 <210> 3259 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3259 agtggatccc tcagtggtta ctac 24 <210> 3260 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3260 Ser Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3261 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3261 atcgatcata ctggaagcac c 21 <210> 3262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3262 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3263 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3263 gcgagagggt ctcgtataac agatcgagac tggtacttcg atccc 45 <210> 3264 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3264 Ala Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Pro 1 5 10 15 <210> 3265 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3265 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gagtattacc agccacttcg cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctacagtct 240 gaagattttg cagtttatta ctgtcagcaa tatgataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3266 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3266 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Ile Thr Ser His 20 25 30 Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3267 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3267 cagagtatta ccagccac 18 <210> 3268 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3268 Gln Ser Ile Thr Ser His 1 5 <210> 3269 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3269 ggtgcatcc 9 <210> 3270 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3270 Gly Ala Ser 1 <210> 3271 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3271 cagcaatatg ataactggcc gtacact 27 <210> 3272 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3272 Gln Gln Tyr Asp Asn Trp Pro Tyr Thr 1 5 <210> 3273 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3273 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcactg tctatggtgg gaccctcagt ggttactatt ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagcac caacttcaat 180 ccgtccctca agagtcgagt caccatatca gtagacccgt ccaagaacca gttctccctg 240 aatctgagct ctgtgaccgc cgcggacacg gctgtgtatt tctgtgcgag aggctctctt 300 ataacatctc gagactggtt cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3274 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3274 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Tyr Gly Gly Thr Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Phe Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Pro Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Ser Arg Asp Trp Phe Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3275 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3275 ggtgggaccc tcagtggtta ctat 24 <210> 3276 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3276 Gly Gly Thr Leu Ser Gly Tyr Tyr 1 5 <210> 3277 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3277 atcgatcata ctggaagcac c 21 <210> 3278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3278 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3279 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3279 gcgagaggct ctcttataac atctcgagac tggttcttcg atctc 45 <210> 3280 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3280 Ala Arg Gly Ser Leu Ile Thr Ser Arg Asp Trp Phe Phe Asp Leu 1 5 10 15 <210> 3281 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3281 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtcttagc agcaacttag cctggtacca gcagagacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttattg ctgtcagcaa tatgataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3282 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3282 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Cys Cys Gln Gln Tyr Asp Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3283 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3283 cagagtctta gcagcaac 18 <210> 3284 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3284 Gln Ser Leu Ser Ser Asn 1 5 <210> 3285 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3285 ggtgcatcc 9 <210> 3286 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3286 Gly Ala Ser 1 <210> 3287 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3287 cagcaatatg ataactggcc gtacact 27 <210> 3288 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3288 Gln Gln Tyr Asp Asn Trp Pro Tyr Thr 1 5 <210> 3289 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3289 caggtgcagc tggtgcagtg gggcgcaggc ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatttca gtagacacgt ccaagaacca gttctccctg 240 aagctgagtt ctgtgaccgc cgcggacacg gctgtgtatt attgtgcgag aggctctctt 300 ataacatctc gagactggca cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3290 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3290 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Ser Arg Asp Trp His Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3291 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3291 ggtgggtcct tcagtggtta ctac 24 <210> 3292 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3292 Gly Gly Ser Phe Ser Gly Tyr Tyr 1 5 <210> 3293 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3293 atcgatcata ctggaagcac c 21 <210> 3294 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3294 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3295 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3295 gcgagaggct ctcttataac atctcgagac tggcacttcg atctc 45 <210> 3296 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3296 Ala Arg Gly Ser Leu Ile Thr Ser Arg Asp Trp His Phe Asp Leu 1 5 10 15 <210> 3297 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3297 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcttccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tatgataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3298 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3298 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3299 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3299 cagagtgtta gcagcaac 18 <210> 3300 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3300 Gln Ser Val Ser Ser Asn 1 5 <210> 3301 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3301 ggtgcttcc 9 <210> 3302 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3302 Gly Ala Ser 1 <210> 3303 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3303 cagcagtatg ataactggcc gtacact 27 <210> 3304 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3304 Gln Gln Tyr Asp Asn Trp Pro Tyr Thr 1 5 <210> 3305 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3305 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccatcagt gtttactact ggagcttgat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccgagaacca gttctccctg 240 aagctgacct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctctctt 300 ataacagatc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3306 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3306 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Ile Ser Val Tyr 20 25 30 Tyr Trp Ser Leu Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Glu Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3307 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3307 ggtgggtcca tcagtgttta ctac 24 <210> 3308 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3308 Gly Gly Ser Ile Ser Val Tyr Tyr 1 5 <210> 3309 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3309 atcgatcata ctggaagcac c 21 <210> 3310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3310 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3311 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3311 gcgagaggct ctcttataac agatcgagac tggtacttcg atctc 45 <210> 3312 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3312 Ala Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3313 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3313 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 3314 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3314 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3315 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3315 caggacatta gcaactat 18 <210> 3316 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3316 Gln Asp Ile Ser Asn Tyr 1 5 <210> 3317 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3317 gatgcatcc 9 <210> 3318 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3318 Asp Ala Ser 1 <210> 3319 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3319 caacagtatg ataatctccc gctcact 27 <210> 3320 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3320 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 3321 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3321 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcagt ggttactact ggagctggat ccgccagccc 120 ccagggaagg ggctggaatg gattggggaa atcgatcata ctggaagcac caactacaat 180 ccgtccctca agagtcgagt caccatatcc gtcgacacgt cccagaacca gctctccctg 240 aagttgacct ctgtgaccgc cgcggacacg gctgtgtact tttgtgcgag aggctctctt 300 ataacagatc gagactggta cttcgatttc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3322 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3322 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Gln Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Phe Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3323 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3323 ggtgggtccc tcagtggtta ctac 24 <210> 3324 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3324 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3325 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3325 atcgatcata ctggaagcac c 21 <210> 3326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3326 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3327 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3327 gcgagaggct ctcttataac agatcgagac tggtacttcg atttc 45 <210> 3328 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3328 Ala Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Phe 1 5 10 15 <210> 3329 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3329 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtattagc agccacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca ggtccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcaacaa tataatgact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3330 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3330 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser His 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ser Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3331 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3331 cagagtatta gcagccac 18 <210> 3332 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3332 Gln Ser Ile Ser Ser His 1 5 <210> 3333 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3333 ggtgcatcc 9 <210> 3334 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3334 Gly Ala Ser 1 <210> 3335 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3335 caacaatata atgactggcc gtacact 27 <210> 3336 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3336 Gln Gln Tyr Asn Asp Trp Pro Tyr Thr 1 5 <210> 3337 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3337 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcagt ggttactact ggaactggat ccgccagccc 120 ccagggaagg ggctggcgtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgacct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctctcgt 300 ataacagatc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3338 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3338 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Ala Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3339 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3339 ggtgggtccc tcagtggtta ctac 24 <210> 3340 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3340 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3341 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3341 atcgatcata ctggaagcac c 21 <210> 3342 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3342 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3343 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3343 gcgagaggct ctcgtataac agatcgagac tggtacttcg atctc 45 <210> 3344 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3344 Ala Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3345 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3345 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaactttg cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct cctctatggt ggatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcat tatgataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3346 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3346 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Leu 35 40 45 Tyr Gly Gly Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asp Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3347 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3347 cagagtgtta gcagcaac 18 <210> 3348 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3348 Gln Ser Val Ser Ser Asn 1 5 <210> 3349 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3349 ggtggatcc 9 <210> 3350 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3350 Gly Gly Ser 1 <210> 3351 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3351 cagcattatg ataactggcc gtacact 27 <210> 3352 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3352 Gln His Tyr Asp Asn Trp Pro Tyr Thr 1 5 <210> 3353 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3353 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgttg tggatagtgg atccctcagt ggttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatct gtagacacgt ccaagaacca gttctcactg 240 aggctgacct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag agggtctcgt 300 ataacagatc gagactggta tttcgatccc tggggccgtg gctccctggt caccgtctcc 360 tca 363 <210> 3354 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3354 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Val Val Asp Ser Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Pro Trp Gly 100 105 110 Arg Gly Ser Leu Val Thr Val Ser Ser 115 120 <210> 3355 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3355 agtggatccc tcagtggtta ctac 24 <210> 3356 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3356 Ser Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3357 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3357 atcgatcata ctggaagcac c 21 <210> 3358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3358 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3359 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3359 gcgagagggt ctcgtataac agatcgagac tggtatttcg atccc 45 <210> 3360 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3360 Ala Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Pro 1 5 10 15 <210> 3361 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3361 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gagtattacc agccacttcg cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcaa tatgataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3362 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3362 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Ile Thr Ser His 20 25 30 Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3363 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3363 cagagtatta ccagccac 18 <210> 3364 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3364 Gln Ser Ile Thr Ser His 1 5 <210> 3365 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3365 ggtgcatcc 9 <210> 3366 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3366 Gly Ala Ser 1 <210> 3367 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3367 cagcaatatg ataactggcc gtacact 27 <210> 3368 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3368 Gln Gln Tyr Asp Asn Trp Pro Tyr Thr 1 5 <210> 3369 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3369 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcagt ggttactact ggagctggat ccgccagccc 120 ccagggaagg ggctggaatg gattggggaa atcgatcata ctggaagtac caactacaat 180 ccgtccctca agagtcgagt caccatatcc gtcgacacgt cccagaacca gctctccctg 240 aagttgacct ctgtgaccgc cgcggacacg gctgtgtact tctgtgcgag aggctctctt 300 ataacagatc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3370 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3370 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Gln Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3371 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3371 ggtgggtccc tcagtggtta ctac 24 <210> 3372 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3372 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3373 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3373 atcgatcata ctggaagtac c 21 <210> 3374 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3374 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3375 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3375 gcgagaggct ctcttataac agatcgagac tggtacttcg atctc 45 <210> 3376 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3376 Ala Arg Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3377 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3377 gacatcgtga tgacccagtc tccaggcacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtattagc agccacttag cctggtatca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg gagtttatta ctgtcaacaa tataatgact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3378 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3378 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser His 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3379 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3379 cagagtatta gcagccac 18 <210> 3380 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3380 Gln Ser Ile Ser Ser His 1 5 <210> 3381 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3381 ggtgcatcc 9 <210> 3382 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3382 Gly Ala Ser 1 <210> 3383 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3383 caacaatata atgactggcc gtacact 27 <210> 3384 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3384 Gln Gln Tyr Asn Asp Trp Pro Tyr Thr 1 5 <210> 3385 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3385 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tgtatggtgg atccttaagt ggttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattggggaa atcgatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgact caccatatca gtggacacgt ccaggaacca attctcactg 240 aagctgagtt ctgtgaccgc cgcggacacg gctgtttatt actgtacgag agggtctcgt 300 ataacagatc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3386 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3386 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr 85 90 95 Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3387 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3387 ggtggatcct taagtggtta ctac 24 <210> 3388 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3388 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3389 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3389 atcgatcata ctggaagcac c 21 <210> 3390 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3390 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3391 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3391 acgagagggt ctcgtataac agatcgagac tggtacttcg atctc 45 <210> 3392 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3392 Thr Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3393 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3393 gacatcgtga tgacccagtc tccttccacc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attcccaatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 3394 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3394 Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Gln 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3395 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3395 cagagtatta gtagctgg 18 <210> 3396 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3396 Gln Ser Ile Ser Ser Trp 1 5 <210> 3397 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3397 aaggcgtct 9 <210> 3398 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3398 Lys Ala Ser 1 <210> 3399 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3399 caacagtata atagttattc ccaattcact 30 <210> 3400 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3400 Gln Gln Tyr Asn Ser Tyr Ser Gln Phe Thr 1 5 10 <210> 3401 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3401 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc ctgcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcagt ggctactatt ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagtac caactacaat 180 ccgtccctca agagtcgagt caccatatca gtcgacacgt ccaagaacct actctccctg 240 aggctgactt ctgtgaccga cgcggacacg gctgtgtatt actgtgcgag aggcactctt 300 atcacagatc gagactggta cttcggtctc tggggccgtg gctccctggt caccgtctcc 360 tca 363 <210> 3402 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3402 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ala Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Leu Leu Ser Leu 65 70 75 80 Arg Leu Thr Ser Val Thr Asp Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Thr Leu Ile Thr Asp Arg Asp Trp Tyr Phe Gly Leu Trp Gly 100 105 110 Arg Gly Ser Leu Val Thr Val Ser Ser 115 120 <210> 3403 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3403 ggtgggtccc tcagtggcta ctat 24 <210> 3404 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3404 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3405 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3405 atcgatcata ctggaagtac c 21 <210> 3406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3406 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3407 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3407 gcgagaggca ctcttatcac agatcgagac tggtacttcg gtctc 45 <210> 3408 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3408 Ala Arg Gly Thr Leu Ile Thr Asp Arg Asp Trp Tyr Phe Gly Leu 1 5 10 15 <210> 3409 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3409 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gagccagtca gagtattagt gaccacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gaatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tataataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3410 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3410 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp His 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Glu Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3411 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3411 cagagtatta gtgaccac 18 <210> 3412 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3412 Gln Ser Ile Ser Asp His 1 5 <210> 3413 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3413 ggtgaatcc 9 <210> 3414 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3414 Gly Glu Ser 1 <210> 3415 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3415 cagcagtata ataactggcc gtacact 27 <210> 3416 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3416 Gln Gln Tyr Asn Asn Trp Pro Tyr Thr 1 5 <210> 3417 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3417 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcaat ggttactact ggaactggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcgatcata ctggaagcac caacttcaat 180 ccgtccctca agagtcgagt caccatatca gtcgacacgt ccaagagcca gctctccctg 240 aagctgagct ctgtgaccgc cgcggacacg gctgtttact actgtgcgaa aggctctctt 300 attacagatc gagactggta cttcgatctc tggggccgtg gcaccctggt caccgtctcc 360 tca 363 <210> 3418 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3418 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Asn Gly Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asp His Thr Gly Ser Thr Asn Phe Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Leu Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu Trp Gly 100 105 110 Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3419 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3419 ggtgggtccc tcaatggtta ctac 24 <210> 3420 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3420 Gly Gly Ser Leu Asn Gly Tyr Tyr 1 5 <210> 3421 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3421 atcgatcata ctggaagcac c 21 <210> 3422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3422 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3423 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3423 gcgaaaggct ctcttattac agatcgagac tggtacttcg atctc 45 <210> 3424 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3424 Ala Lys Gly Ser Leu Ile Thr Asp Arg Asp Trp Tyr Phe Asp Leu 1 5 10 15 <210> 3425 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3425 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca tagtattagc agccacttcg cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcaacac tataataact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3426 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3426 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Ile Ser Ser His 20 25 30 Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3427 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3427 catagtatta gcagccac 18 <210> 3428 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3428 His Ser Ile Ser Ser His 1 5 <210> 3429 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3429 ggtgcatcc 9 <210> 3430 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3430 Gly Ala Ser 1 <210> 3431 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3431 caacactata ataactggcc gtacact 27 <210> 3432 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3432 Gln His Tyr Asn Asn Trp Pro Tyr Thr 1 5 <210> 3433 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3433 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactg 60 tcctgtgcag cgtccggatt caccttcagt acctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaaataa gaaatactat 180 ggagactccg tgaagggccg attcaccata tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacagtcc 300 ggtatagtgg gagctacccc atttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 3434 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3434 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Asn Lys Lys Tyr Tyr Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3435 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3435 ggattcacct tcagtaccta tggc 24 <210> 3436 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3436 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 3437 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3437 atatggtatg atggaaataa gaaa 24 <210> 3438 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3438 Ile Trp Tyr Asp Gly Asn Lys Lys 1 5 <210> 3439 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3439 gcgagacagt ccggtatagt gggagctacc ccatttgact ac 42 <210> 3440 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3440 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr 1 5 10 <210> 3441 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3441 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagtattagc aggtatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccattcat tttcggccct 300 gggaccaagg tggaaatcaa acga 324 <210> 3442 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3442 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3443 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3443 cagagtatta gcaggtat 18 <210> 3444 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3444 Gln Ser Ile Ser Arg Tyr 1 5 <210> 3445 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3445 gctgcatcc 9 <210> 3446 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3446 Ala Ala Ser 1 <210> 3447 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3447 caacagagtt acagtacccc attcatt 27 <210> 3448 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3448 Gln Gln Ser Tyr Ser Thr Pro Phe Ile 1 5 <210> 3449 <211> 350 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3449 gaggtgcagc tggtggagtc tggaggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttacc agctactgca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcaatt atttatagtg gtggtatcag atactacgca 180 gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg 240 caaatgaaca gcctgagagc cgaggacacg gccatgtatt actgtgcgag cgggttagca 300 actgcggttt ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 350 <210> 3450 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3450 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 20 25 30 Cys Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ile Ile Tyr Ser Gly Gly Ile Arg Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 85 90 95 Ser Gly Leu Ala Thr Ala Val Trp Thr Ser Gly Ala Lys Gly Pro Arg 100 105 110 Ser Pro Ser Pro 115 <210> 3451 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3451 ggattcacct ttaccagcta ctgc 24 <210> 3452 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3452 Gly Phe Thr Phe Thr Ser Tyr Cys 1 5 <210> 3453 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3453 atttatagtg gtggtatcag a 21 <210> 3454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3454 Ile Tyr Ser Gly Gly Ile Arg 1 5 <210> 3455 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3455 gcgagcgggt tagcaactgc ggtttgg 27 <210> 3456 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3456 Ala Ser Gly Leu Ala Thr Ala Val Trp 1 5 <210> 3457 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3457 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcatcaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctacgctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 3458 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3458 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3459 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3459 cagggcatca gaaatgat 18 <210> 3460 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3460 Gln Gly Ile Arg Asn Asp 1 5 <210> 3461 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3461 gctgcatcc 9 <210> 3462 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3462 Ala Ala Ser 1 <210> 3463 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3463 caacagagtt acagtacccc gctcact 27 <210> 3464 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3464 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 3465 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3465 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctataaca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaggtaa taaatactat 180 acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cactctttat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagacaatcc 300 ggtatagtgg gagctacccc atttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 3466 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3466 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Gly Asn Lys Tyr Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3467 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3467 ggattcacct tcagtaccta taac 24 <210> 3468 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3468 Gly Phe Thr Phe Ser Thr Tyr Asn 1 5 <210> 3469 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3469 atatggtatg atggaggtaa taaa 24 <210> 3470 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3470 Ile Trp Tyr Asp Gly Gly Asn Lys 1 5 <210> 3471 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3471 gcgagacaat ccggtatagt gggagctacc ccatttgact ac 42 <210> 3472 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3472 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr 1 5 10 <210> 3473 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3473 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aggtatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacagta ccccattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3474 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3474 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3475 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3475 cagagcatta gcaggtat 18 <210> 3476 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3476 Gln Ser Ile Ser Arg Tyr 1 5 <210> 3477 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3477 gctgcatcc 9 <210> 3478 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3478 Ala Ala Ser 1 <210> 3479 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3479 caacagactt acagtacccc attcatt 27 <210> 3480 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3480 Gln Gln Thr Tyr Ser Thr Pro Phe Ile 1 5 <210> 3481 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3481 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctataaca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaggtaa taaatactat 180 acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cactctttat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagacaatcc 300 ggtatagtgg gagctacccc atttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 3482 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3482 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Gly Asn Lys Tyr Tyr Thr Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3483 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3483 ggattcacct tcagtaccta taac 24 <210> 3484 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3484 Gly Phe Thr Phe Ser Thr Tyr Asn 1 5 <210> 3485 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3485 atatggtatg atggaggtaa taaa 24 <210> 3486 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3486 Ile Trp Tyr Asp Gly Gly Asn Lys 1 5 <210> 3487 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3487 gcgagacaat ccggtatagt gggagctacc ccatttgact ac 42 <210> 3488 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3488 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr 1 5 10 <210> 3489 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3489 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aggtatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacagta ccccattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3490 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3490 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3491 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3491 cagagcatta gcaggtat 18 <210> 3492 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3492 Gln Ser Ile Ser Arg Tyr 1 5 <210> 3493 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3493 gctgcatcc 9 <210> 3494 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3494 Ala Ala Ser 1 <210> 3495 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3495 caacagactt acagtacccc attcatt 27 <210> 3496 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3496 Gln Gln Thr Tyr Ser Thr Pro Phe Ile 1 5 <210> 3497 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3497 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccctcagt ggttactact ggagctggat ccgccagtcc 120 ccaggaaagg gactggcgtg gattgcggaa atcgatcata ctggaagcac caactacaat 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aggctgagtt cagtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctctcgt 300 ataacagatc gagactggta cttcggtctc tggggccgtg gctccctggt caccgtctcc 360 tca 363 <210> 3498 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3498 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Leu Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Ala Trp Ile 35 40 45 Ala Glu Ile Asp His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Gly Leu Trp Gly 100 105 110 Arg Gly Ser Leu Val Thr Val Ser Ser 115 120 <210> 3499 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3499 ggtgggtccc tcagtggtta ctac 24 <210> 3500 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3500 Gly Gly Ser Leu Ser Gly Tyr Tyr 1 5 <210> 3501 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3501 atcgatcata ctggaagcac c 21 <210> 3502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3502 Ile Asp His Thr Gly Ser Thr 1 5 <210> 3503 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3503 gcgagaggct ctcgtataac agatcgagac tggtacttcg gtctc 45 <210> 3504 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3504 Ala Arg Gly Ser Arg Ile Thr Asp Arg Asp Trp Tyr Phe Gly Leu 1 5 10 15 <210> 3505 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3505 gacatcgtga tgacccagtc tgcagacacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gactgttagc agccacttag cctggtacca gcagaaacct 120 ggccagtctc ccaggctcct cctctattct ggatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca tcatcagtgg cctgcagtct 240 gaagattttg cagtttatta ctgtcagcaa tacaatgact ggccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3506 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3506 Asp Ile Val Met Thr Gln Ser Ala Asp Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser His 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Leu 35 40 45 Tyr Ser Gly Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Ile Ser Gly Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3507 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3507 cagactgtta gcagccac 18 <210> 3508 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3508 Gln Thr Val Ser Ser His 1 5 <210> 3509 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3509 tctggatcc 9 <210> 3510 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3510 Ser Gly Ser 1 <210> 3511 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3511 cagcaataca atgactggcc gtacact 27 <210> 3512 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3512 Gln Gln Tyr Asn Asp Trp Pro Tyr Thr 1 5 <210> 3513 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3513 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccggcaggct 120 ccaggcaagg ggctggagtg ggtggcagtt ataaggtatg atggaagtaa aaaagactat 180 gtagacttcg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacaatcc 300 ggaatagtgg gagccacccc atttgactac tggggccagg gaaccatggt caccgtctcc 360 tca 363 <210> 3514 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3514 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Arg Tyr Asp Gly Ser Lys Lys Asp Tyr Val Asp Phe Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3515 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3515 ggattcacct tcagtagcta tggc 24 <210> 3516 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3516 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 3517 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3517 ataaggtatg atggaagtaa aaaa 24 <210> 3518 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3518 Ile Arg Tyr Asp Gly Ser Lys Lys 1 5 <210> 3519 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3519 gcgagacaat ccggaatagt gggagccacc ccatttgact ac 42 <210> 3520 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3520 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr 1 5 10 <210> 3521 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3521 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aggtatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca tcatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta tcccattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3522 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3522 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3523 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3523 cagagcatta gcaggtat 18 <210> 3524 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3524 Gln Ser Ile Ser Arg Tyr 1 5 <210> 3525 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3525 gctgcatcc 9 <210> 3526 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3526 Ala Ala Ser 1 <210> 3527 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3527 caacagagtt acagtatccc attcatt 27 <210> 3528 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3528 Gln Gln Ser Tyr Ser Ile Pro Phe Ile 1 5 <210> 3529 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3529 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccggcaggct 120 ccaggcaagg ggctggagtg ggtggcagtt ataaggtatg atggaagtaa aaaagactat 180 gtagacttcg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacaatcc 300 ggaatagtgg gagccacccc atttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 3530 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3530 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Arg Tyr Asp Gly Ser Lys Lys Asp Tyr Val Asp Phe Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3531 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3531 ggattcacct tcagtagcta tggc 24 <210> 3532 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3532 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 3533 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3533 ataaggtatg atggaagtaa aaaa 24 <210> 3534 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3534 Ile Arg Tyr Asp Gly Ser Lys Lys 1 5 <210> 3535 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3535 gcgagacaat ccggaatagt gggagccacc ccatttgact ac 42 <210> 3536 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3536 Ala Arg Gln Ser Gly Ile Val Gly Ala Thr Pro Phe Asp Tyr 1 5 10 <210> 3537 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3537 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc aggtatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca tcatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta tcccattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3538 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3538 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3539 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3539 cagagcatta gcaggtat 18 <210> 3540 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3540 Gln Ser Ile Ser Arg Tyr 1 5 <210> 3541 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3541 gctgcatcc 9 <210> 3542 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3542 Ala Ala Ser 1 <210> 3543 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3543 caacagagtt acagtatccc attcatt 27 <210> 3544 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3544 Gln Gln Ser Tyr Ser Ile Pro Phe Ile 1 5 <210> 3545 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3545 gaggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctt attagttggg atggtggtag aacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac aactgaggac accgccttgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3546 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3546 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Trp Asp Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3547 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3547 ggattcacct ttgatgatta tgcc 24 <210> 3548 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3548 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3549 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3549 attagttggg atggtggtag aaca 24 <210> 3550 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3550 Ile Ser Trp Asp Gly Gly Arg Thr 1 5 <210> 3551 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3551 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3552 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3552 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3553 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3553 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattattaat gacaactact tcgcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcggtgta ttactgtcag cattatggta cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3554 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3554 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Ile Asn Asp Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3555 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3555 cagattatta atgacaacta c 21 <210> 3556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3556 Gln Ile Ile Asn Asp Asn Tyr 1 5 <210> 3557 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3557 gctacatcc 9 <210> 3558 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3558 Ala Thr Ser 1 <210> 3559 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3559 cagcattatg gtacctcacc tcct 24 <210> 3560 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3560 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3561 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3561 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt gattactact ggagctggat ccggcagccc 120 ccagggaagg gactggaatg gattggatat atctattaca ctgggagcac caaccacaac 180 ccctccctca agagtcggtt caccatatca ttggacacgt ccaggaacca gttctccctg 240 aagctgagct ctgtgaccgc cgcagacacg gccgtgtatt tctgtgcgcg acaaaacggt 300 gactcttttg actactgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 3562 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3562 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Thr Gly Ser Thr Asn His Asn Pro Ser Leu Lys 50 55 60 Ser Arg Phe Thr Ile Ser Leu Asp Thr Ser Arg Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Gln Asn Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 3563 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3563 ggtggctcca tcagtgatta ctac 24 <210> 3564 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3564 Gly Gly Ser Ile Ser Asp Tyr Tyr 1 5 <210> 3565 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3565 atctattaca ctgggagcac c 21 <210> 3566 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3566 Ile Tyr Tyr Thr Gly Ser Thr 1 5 <210> 3567 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3567 gcgcgacaaa acggtgactc ttttgactac 30 <210> 3568 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3568 Ala Arg Gln Asn Gly Asp Ser Phe Asp Tyr 1 5 10 <210> 3569 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3569 gacatcctga tgacccagtc tccgtcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagcca gagcattgcc aactatttaa attggtatcg ccagcaacca 120 ggtagagccc ctaacctcct gatctatgct gcatccagat tgcaacgtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacatat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg caacttacta ctgtcaacag tgttacacta ccccatactc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3570 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3570 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Asn Tyr 20 25 30 Leu Asn Trp Tyr Arg Gln Gln Pro Gly Arg Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Cys Tyr Thr Thr Pro Tyr 85 90 95 Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3571 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3571 cagagcattg ccaactat 18 <210> 3572 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3572 Gln Ser Ile Ala Asn Tyr 1 5 <210> 3573 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3573 gctgcatcc 9 <210> 3574 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3574 Ala Ala Ser 1 <210> 3575 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3575 caacagtgtt acactacccc atactct 27 <210> 3576 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3576 Gln Gln Cys Tyr Thr Thr Pro Tyr Ser 1 5 <210> 3577 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3577 caggtgcagc tggtggagtc ggggggaggc gtagtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct 120 ccagggaagg gtctggagtg ggtctctctc attaattggg atggacataa tacatattat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtgg 240 ctgcaaatga acagtctgag aactgaagac agcgccttgt attactgtgc aaaagagatt 300 tccccttcta cagatcctta ttacttctac tacttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3578 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3578 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Asn Trp Asp Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Trp 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Ser Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Phe Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3579 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3579 ggattcacct ttgatgatta tgcc 24 <210> 3580 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3580 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3581 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3581 attaattggg atggacataa taca 24 <210> 3582 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3582 Ile Asn Trp Asp Gly His Asn Thr 1 5 <210> 3583 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3583 gcaaaagaga tttccccttc tacagatcct tattacttct actacttcgg tatggacgtc 60 <210> 3584 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3584 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Phe Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3585 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3585 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgtaagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gtagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcaatgta ttactgtcag cactatgttg gttcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3586 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3586 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln His Tyr Val Gly Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3587 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3587 cagagtgtaa gcagcagcta c 21 <210> 3588 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3588 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 3589 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3589 gctacatcc 9 <210> 3590 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3590 Ala Thr Ser 1 <210> 3591 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3591 cagcactatg ttggttcacc tcct 24 <210> 3592 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3592 Gln His Tyr Val Gly Ser Pro Pro 1 5 <210> 3593 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3593 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt ggttattatt ggagttggat ccggcagccc 120 ccagggaagg gactggagtg gattggttac atctattaca ctgggagcac caattacaat 180 ccctccctcg agagtcgagt caccatatca gtggacacgt ccaagaatca gttctccctg 240 aagttgaagt ctgtgactgc cgcagacacg gccgtgtatt actgtgcgag agatgacgcg 300 gactacaacg gtatggacgt ctggggccaa gggaccatgg tcaccgtctc ctca 354 <210> 3594 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3594 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 3595 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3595 ggtggctcca tcagtggtta ttat 24 <210> 3596 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3596 Gly Gly Ser Ile Ser Gly Tyr Tyr 1 5 <210> 3597 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3597 atctattaca ctgggagcac c 21 <210> 3598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3598 Ile Tyr Tyr Thr Gly Ser Thr 1 5 <210> 3599 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3599 gcgagagatg acgcggacta caacggtatg gacgtc 36 <210> 3600 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3600 Ala Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 3601 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3601 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60 atctcctgca ggtctagtca aagtctcata tacaatgatg gaaaaattta tttgaattgg 120 tttcagcaga ggccaggcca atctccaagg cgcctgattt ataaggtttc taaccgggac 180 tctggggtcc cagacagatt caggggcagt gggtcaggca ctgaattcac actgaaaatc 240 agcagggtgg aggctgagga tgttggggtt tattattgca tgcaaagtac acactggccg 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 3602 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3602 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Asn 20 25 30 Asp Gly Lys Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 85 90 95 Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 3603 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3603 caaagtctca tatacaatga tggaaaaatt tat 33 <210> 3604 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3604 Gln Ser Leu Ile Tyr Asn Asp Gly Lys Ile Tyr 1 5 10 <210> 3605 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3605 aaggtttct 9 <210> 3606 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3606 Lys Val Ser 1 <210> 3607 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3607 atgcaaagta cacactggcc gctcact 27 <210> 3608 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3608 Met Gln Ser Thr His Trp Pro Leu Thr 1 5 <210> 3609 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3609 gaggtgcagc tggtggagtc tgggggagac ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttggt gattatgcca tgcactgggt ccggcaaggt 120 ccagggaagg gcctggagtg ggtctcaagt attagttgga gtggtgagaa cgtcgcctat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag acctgaggac acggccctct actattgtgc aaaagatata 300 tgggactact tcggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca 357 <210> 3610 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3610 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Trp Ser Gly Glu Asn Val Ala Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Trp Asp Tyr Phe Gly Met Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 3611 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3611 ggattcacct ttggtgatta tgcc 24 <210> 3612 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3612 Gly Phe Thr Phe Gly Asp Tyr Ala 1 5 <210> 3613 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3613 attagttgga gtggtgagaa cgtc 24 <210> 3614 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3614 Ile Ser Trp Ser Gly Glu Asn Val 1 5 <210> 3615 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3615 gcaaaagata tatgggacta cttcggtatg gacgtc 36 <210> 3616 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3616 Ala Lys Asp Ile Trp Asp Tyr Phe Gly Met Asp Val 1 5 10 <210> 3617 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3617 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gaaaattaac agcaattact tagtctggta ccagcagaaa 120 cctggccagg cccccaggct cctcatctat ggtgcatcca acagggccac tggcatccca 180 gacaggttca gtggcggtgg gtctgggaca gacttcattc tcactatcag cagactggag 240 cctgaagatt ttgtagtgta ttactgtcac cactatggta cctcgtacac ttttgcccag 300 gggaccaagg tggagatcaa acga 324 <210> 3618 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3618 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Lys Ile Asn Ser Asn 20 25 30 Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Gly Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Val Val Tyr Tyr Cys His His Tyr Gly Thr Ser Tyr 85 90 95 Thr Phe Ala Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3619 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3619 cagaaaatta acagcaatta c 21 <210> 3620 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3620 Gln Lys Ile Asn Ser Asn Tyr 1 5 <210> 3621 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3621 ggtgcatcc 9 <210> 3622 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3622 Gly Ala Ser 1 <210> 3623 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3623 caccactatg gtacctcgta cact 24 <210> 3624 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3624 His His Tyr Gly Thr Ser Tyr Thr 1 5 <210> 3625 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3625 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt gattactact ggagctggat ccggcagccc 120 ccaggaaagg gactggagtg gattggatat atctattaca ctgggagcac caactacaac 180 ccctccctca agagtcggtt caccatatca ttggacacgt ccaggaacca gttctccctg 240 aagctgagct ctgtgaccgc cgcagacacg gccgtgtatt tctgtgcgag acaaaacggt 300 gactcttttg actactgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 3626 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3626 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Phe Thr Ile Ser Leu Asp Thr Ser Arg Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Gln Asn Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 3627 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3627 ggtggctcca tcagtgatta ctac 24 <210> 3628 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3628 Gly Gly Ser Ile Ser Asp Tyr Tyr 1 5 <210> 3629 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3629 atctattaca ctgggagcac c 21 <210> 3630 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3630 Ile Tyr Tyr Thr Gly Ser Thr 1 5 <210> 3631 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3631 gcgagacaaa acggtgactc ttttgactac 30 <210> 3632 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3632 Ala Arg Gln Asn Gly Asp Ser Phe Asp Tyr 1 5 10 <210> 3633 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3633 gacatccaga tgacccagtc tccgtcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagcca gagtattagt agctatttaa attggtatcg gcagcaacca 120 gggagagccc ctaacctcct gatctatgct gcatccagat tgcaacgtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacatat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag tgttacagta ccccgtactc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3634 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3634 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Arg Gln Gln Pro Gly Arg Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Cys Tyr Ser Thr Pro Tyr 85 90 95 Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3635 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3635 cagagtatta gtagctat 18 <210> 3636 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3636 Gln Ser Ile Ser Ser Tyr 1 5 <210> 3637 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3637 gctgcatcc 9 <210> 3638 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3638 Ala Ala Ser 1 <210> 3639 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3639 caacagtgtt acagtacccc gtactct 27 <210> 3640 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3640 Gln Gln Cys Tyr Ser Thr Pro Tyr Ser 1 5 <210> 3641 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3641 gaggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctt attagttggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac aactgaggac accgccttgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3642 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3642 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3643 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3643 ggattcacct ttgatgatta tgcc 24 <210> 3644 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3644 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3645 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3645 attagttggg atggtggtag caca 24 <210> 3646 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3646 Ile Ser Trp Asp Gly Gly Ser Thr 1 5 <210> 3647 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3647 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3648 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3648 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3649 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3649 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattattaat ggcaactact tcgcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cattatggta cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3650 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3650 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Ile Asn Gly Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3651 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3651 cagattatta atggcaacta c 21 <210> 3652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3652 Gln Ile Ile Asn Gly Asn Tyr 1 5 <210> 3653 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3653 gctacatcc 9 <210> 3654 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3654 Ala Thr Ser 1 <210> 3655 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3655 cagcattatg gtacctcacc tcct 24 <210> 3656 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3656 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3657 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3657 gaggtgcagc tggtggagtc tggaacagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aggaactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatgggcatc atctatcctc gtgactcaga taccagatac 180 agtccgtcct tccaaggcca ggtcaccatg ttagtcgaca agtcaagtag taccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccgtgt attactgtgc gagactcggg 300 gacctatata actactacta tggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 3658 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3658 Glu Val Gln Leu Val Glu Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Arg Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Arg Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Leu Val Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Leu Gly Asp Leu Tyr Asn Tyr Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3659 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3659 ggatacacct ttaccaggaa ctgg 24 <210> 3660 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3660 Gly Tyr Thr Phe Thr Arg Asn Trp 1 5 <210> 3661 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3661 atctatcctc gtgactcaga tacc 24 <210> 3662 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3662 Ile Tyr Pro Arg Asp Ser Asp Thr 1 5 <210> 3663 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3663 gcgagactcg gggacctata taactactac tatggtatgg acgtc 45 <210> 3664 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3664 Ala Arg Leu Gly Asp Leu Tyr Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 3665 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3665 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattaac agctatttaa attggtatca gcagaaatca 120 gggaaagccc ctaacctcct gctctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caactttcta ctgtcaacag agttacagtg ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3666 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3666 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Asn Leu Leu Leu 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Phe Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3667 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3667 cagaccatta acagctat 18 <210> 3668 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3668 Gln Thr Ile Asn Ser Tyr 1 5 <210> 3669 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3669 gctgcatcc 9 <210> 3670 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3670 Ala Ala Ser 1 <210> 3671 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3671 caacagagtt acagtgcccc gtacact 27 <210> 3672 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3672 Gln Gln Ser Tyr Ser Ala Pro Tyr Thr 1 5 <210> 3673 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3673 gaggtgcagc tggtggagtc tgggggaggc gtggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct 120 ccagggaagg gtctggagtg ggtctctctt attactgggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac accgccttgt attactgtgc aaaagataga 300 gctggaacta actactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 3674 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3674 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Thr Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Arg Ala Gly Thr Asn Tyr Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3675 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3675 ggattcacct ttgatgatta tgcc 24 <210> 3676 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3676 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3677 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3677 attactgggg atggtggtag caca 24 <210> 3678 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3678 Ile Thr Gly Asp Gly Gly Ser Thr 1 5 <210> 3679 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3679 gcaaaagata gagctggaac taactactac tacggtatgg acgtc 45 <210> 3680 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3680 Ala Lys Asp Arg Ala Gly Thr Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 3681 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3681 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcatcgat caccttcggc 300 caagggacca aactggagat caaacga 327 <210> 3682 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3682 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 3683 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3683 cagagtgtta gcagcagcta c 21 <210> 3684 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3684 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 3685 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3685 ggtgcatcc 9 <210> 3686 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3686 Gly Ala Ser 1 <210> 3687 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3687 cagcagtatg gtagctcatc gatcacc 27 <210> 3688 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3688 Gln Gln Tyr Gly Ser Ser Ser Ile Thr 1 5 <210> 3689 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3689 gaggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgaa gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctttt attaattggg atggtggcag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac aactgaggac accgccgtgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3690 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3690 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Phe Ile Asn Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3691 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3691 ggattcacct ttgaagatta tgcc 24 <210> 3692 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3692 Gly Phe Thr Phe Glu Asp Tyr Ala 1 5 <210> 3693 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3693 attaattggg atggtggcag caca 24 <210> 3694 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3694 Ile Asn Trp Asp Gly Gly Ser Thr 1 5 <210> 3695 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3695 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3696 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3696 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3697 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3697 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattattaat gacaactact tcgcctggta tcagcagaaa 120 cctggccagc ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctggtgatt ttgcagtgta ttactgtcag cattatggta cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3698 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3698 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Ile Asn Asp Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Gly Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3699 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3699 cagattatta atgacaacta c 21 <210> 3700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3700 Gln Ile Ile Asn Asp Asn Tyr 1 5 <210> 3701 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3701 gctacatcc 9 <210> 3702 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3702 Ala Thr Ser 1 <210> 3703 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3703 cagcattatg gtacctcacc tcct 24 <210> 3704 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3704 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3705 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3705 gaggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctt attagttggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac aactgaggac accgccttgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3706 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3706 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3707 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3707 ggattcacct ttgatgatta tgcc 24 <210> 3708 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3708 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3709 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3709 attagttggg atggtggtag caca 24 <210> 3710 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3710 Ile Ser Trp Asp Gly Gly Ser Thr 1 5 <210> 3711 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3711 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3712 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3712 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3713 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3713 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattattaat gacaactact tcgcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cattatggta cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3714 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3714 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Ile Asn Asp Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3715 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3715 cagattatta atgacaacta c 21 <210> 3716 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3716 Gln Ile Ile Asn Asp Asn Tyr 1 5 <210> 3717 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3717 gctacatcc 9 <210> 3718 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3718 Ala Thr Ser 1 <210> 3719 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3719 cagcattatg gtacctcacc tcct 24 <210> 3720 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3720 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3721 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3721 gaggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctt attagtgggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga acagtccgag aactgaggac accgccttgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3722 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3722 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Pro Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3723 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3723 ggattcacct ttgatgatta tgcc 24 <210> 3724 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3724 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3725 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3725 attagtgggg atggtggtag caca 24 <210> 3726 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3726 Ile Ser Gly Asp Gly Gly Ser Thr 1 5 <210> 3727 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3727 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3728 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3728 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3729 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3729 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaaag tataacagtg cccctcggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 3730 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3730 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3731 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3731 cagggcatta gcaattat 18 <210> 3732 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3732 Gln Gly Ile Ser Asn Tyr 1 5 <210> 3733 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3733 gctgcatcc 9 <210> 3734 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3734 Ala Ala Ser 1 <210> 3735 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3735 caaaagtata acagtgcccc tcggacg 27 <210> 3736 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3736 Gln Lys Tyr Asn Ser Ala Pro Arg Thr 1 5 <210> 3737 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3737 caggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctt attagttggg atggtggcag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac agctgaggac accgccgtgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3738 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3738 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3739 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3739 ggattcacct ttgatgatta tgcc 24 <210> 3740 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3740 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3741 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3741 attagttggg atggtggcag caca 24 <210> 3742 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3742 Ile Ser Trp Asp Gly Gly Ser Thr 1 5 <210> 3743 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3743 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3744 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3744 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3745 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3745 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattattaat gacaactact tcgcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca ccagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cattatggta cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3746 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3746 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Ile Asn Asp Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3747 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3747 cagattatta atgacaacta c 21 <210> 3748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3748 Gln Ile Ile Asn Asp Asn Tyr 1 5 <210> 3749 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3749 gctacatcc 9 <210> 3750 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3750 Ala Thr Ser 1 <210> 3751 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3751 cagcattatg gtacctcacc tcct 24 <210> 3752 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3752 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3753 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3753 caggtgcagc tggtggagtc tgggggaggc gttataccgc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gactggagtg ggtctctctt attagttggg atggtggttt cacacactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac aactgaggac accgccttgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3754 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3754 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Pro Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Trp Asp Gly Gly Phe Thr His Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3755 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3755 ggattcacct ttgatgatta tgcc 24 <210> 3756 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3756 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3757 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3757 attagttggg atggtggttt caca 24 <210> 3758 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3758 Ile Ser Trp Asp Gly Gly Phe Thr 1 5 <210> 3759 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3759 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3760 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3760 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3761 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3761 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattcttaat ggcaactact tcgcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cattatggca cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3762 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3762 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Leu Asn Gly Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3763 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3763 cagattctta atggcaacta c 21 <210> 3764 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3764 Gln Ile Leu Asn Gly Asn Tyr 1 5 <210> 3765 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3765 gctacatcc 9 <210> 3766 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3766 Ala Thr Ser 1 <210> 3767 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3767 cagcattatg gcacctcacc tcct 24 <210> 3768 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3768 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3769 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3769 gaggtgcagc tggtggagtc tggaggtgag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata caacttttcc aaaaactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctc gtgactctga tatcagatac 180 agtccgtcct tccaaggcca ggtcaccatg tcagccgaca agtccatcaa caccgcctat 240 ctgcagtgga gtagcctgaa ggcctcggac accgccatgt atttctgtgc gagactcggg 300 gacctatggc atcagtatta tggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 3770 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3770 Glu Val Gln Leu Val Glu Ser Gly Gly Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asn Phe Ser Lys Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Arg Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 85 90 95 Ala Arg Leu Gly Asp Leu Trp His Gln Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3771 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3771 ggatacaact tttccaaaaa ctgg 24 <210> 3772 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3772 Gly Tyr Asn Phe Ser Lys Asn Trp 1 5 <210> 3773 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3773 atctatcctc gtgactctga tatc 24 <210> 3774 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3774 Ile Tyr Pro Arg Asp Ser Asp Ile 1 5 <210> 3775 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3775 gcgagactcg gggacctatg gcatcagtat tatggtatgg acgtc 45 <210> 3776 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3776 Ala Arg Leu Gly Asp Leu Trp His Gln Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 3777 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3777 gacatcctga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga cagagtcacc 60 atcacttgcc ggacgagtca gaccattagt aattatttaa attggtatca acagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcat tcttcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagtg ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3778 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3778 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Thr Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ile Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3779 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3779 cagaccatta gtaattat 18 <210> 3780 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3780 Gln Thr Ile Ser Asn Tyr 1 5 <210> 3781 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3781 gctgcatcc 9 <210> 3782 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3782 Ala Ala Ser 1 <210> 3783 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3783 caacagagtt acagtgcccc gtacact 27 <210> 3784 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3784 Gln Gln Ser Tyr Ser Ala Pro Tyr Thr 1 5 <210> 3785 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3785 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cagctttatc aactactgga tcggctgggt gcgccagagg 120 cccgggaagg gcctggagtg gatggggttc atctatcctg gtgactctga taccagatat 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa tattgtctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacaggga 300 aggtatataa taacagctgg tcactttgac cactggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 3786 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3786 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Asn Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Ile Val Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gln Gly Arg Tyr Ile Ile Thr Ala Gly His Phe Asp His Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3787 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3787 ggatacagct ttatcaacta ctgg 24 <210> 3788 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3788 Gly Tyr Ser Phe Ile Asn Tyr Trp 1 5 <210> 3789 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3789 atctatcctg gtgactctga tacc 24 <210> 3790 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3790 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 3791 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3791 gcgagacagg gaaggtatat aataacagct ggtcactttg accac 45 <210> 3792 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3792 Ala Arg Gln Gly Arg Tyr Ile Ile Thr Ala Gly His Phe Asp His 1 5 10 15 <210> 3793 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3793 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaagtcct gatctatgat gtatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacaaaa ccctcacttt cggcggaggg 300 accaaggtgg agatcaaacg a 321 <210> 3794 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3794 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Asp Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Lys Thr Leu Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3795 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3795 cagagcatta gtagctat 18 <210> 3796 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3796 Gln Ser Ile Ser Ser Tyr 1 5 <210> 3797 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3797 gatgtatcc 9 <210> 3798 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3798 Asp Val Ser 1 <210> 3799 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3799 caacagactt acaaaaccct cact 24 <210> 3800 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3800 Gln Gln Thr Tyr Lys Thr Leu Thr 1 5 <210> 3801 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3801 gaggtgcagc tggtggagtc tgggggaggc gtggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagct 120 ccagggaagg gtctggagtg ggtctctctt attagtgggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac accgccttgt attactgtgc aaaaggctcc 300 gactacagta actactttta ctactactac tacggtatgg acgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 3802 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3802 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Ser Asp Tyr Ser Asn Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3803 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3803 ggattcacct ttgatgatta tgcc 24 <210> 3804 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3804 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3805 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3805 attagtgggg atggtggtag caca 24 <210> 3806 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3806 Ile Ser Gly Asp Gly Gly Ser Thr 1 5 <210> 3807 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3807 gcaaaaggct ccgactacag taactacttt tactactact actacggtat ggacgtc 57 <210> 3808 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3808 Ala Lys Gly Ser Asp Tyr Ser Asn Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 1 5 10 15 Met Asp Val <210> 3809 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3809 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga tagagccacc 60 ctctcctgca gggccagtca gagtgtaagc agcagttact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca acagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatgttg gctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3810 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3810 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3811 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3811 cagagtgtaa gcagcagtta c 21 <210> 3812 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3812 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 3813 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3813 gctacatcc 9 <210> 3814 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3814 Ala Thr Ser 1 <210> 3815 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3815 cagcagtatg ttggctcacc tcct 24 <210> 3816 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3816 Gln Gln Tyr Val Gly Ser Pro Pro 1 5 <210> 3817 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3817 gaggtgcagc tggtggagtc ggggggaggc gtagtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctc attaattggg atggacgtag tacatattat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtgg 240 ctgcaaatga acagtctgag aactgaagac agcgccttgt attactgtgc aaaagagatt 300 tccccttcta cagatcctta ttacttctac tacttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3818 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3818 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Asn Trp Asp Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Trp 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Ser Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Phe Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3819 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3819 ggattcacct ttgatgatta tgcc 24 <210> 3820 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3820 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3821 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3821 attaattggg atggacgtag taca 24 <210> 3822 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3822 Ile Asn Trp Asp Gly Arg Ser Thr 1 5 <210> 3823 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3823 gcaaaagaga tttccccttc tacagatcct tattacttct actacttcgg tatggacgtc 60 <210> 3824 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3824 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Phe Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3825 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3825 gacatcgtga tgacccagtc tccaggcacc ctatctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagcttct tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtcta ttactgtcag cagtatgttg gctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3826 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3826 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3827 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3827 cagagtgtta gcagcagctt c 21 <210> 3828 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3828 Gln Ser Val Ser Ser Ser Phe 1 5 <210> 3829 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3829 gctacatcc 9 <210> 3830 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3830 Ala Thr Ser 1 <210> 3831 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3831 cagcagtatg ttggctcacc tcct 24 <210> 3832 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3832 Gln Gln Tyr Val Gly Ser Pro Pro 1 5 <210> 3833 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3833 gaggtgcagc tggtggagtc tgggggaggc gttatacagc ggggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccgtcaagtt 120 ccagggaagg gtctggagtg ggtctctctt attagttggg atggtggtag cacatactat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acagcaaaaa gtccctgtat 240 ctgcaaatga gcagtccgac aactgaggac accgccttgt attactgtgc aaaagagata 300 tccccttcta cagatcctta ttactactac tatttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 3834 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3834 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Arg Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Pro Thr Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3835 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3835 ggattcacct ttgatgatta tgcc 24 <210> 3836 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3836 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3837 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3837 attagttggg atggtggtag caca 24 <210> 3838 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3838 Ile Ser Trp Asp Gly Gly Ser Thr 1 5 <210> 3839 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3839 gcaaaagaga tatccccttc tacagatcct tattactact actatttcgg tatggacgtc 60 <210> 3840 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3840 Ala Lys Glu Ile Ser Pro Ser Thr Asp Pro Tyr Tyr Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 3841 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3841 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca ggaccagtca gattattaat gacaactact tcgcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat gctacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cattatggta cctcacctcc ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 3842 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3842 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ile Ile Asn Asp Asn 20 25 30 Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Thr Ser Pro 85 90 95 Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3843 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3843 cagattatta atgacaacta c 21 <210> 3844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3844 Gln Ile Ile Asn Asp Asn Tyr 1 5 <210> 3845 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3845 gctacatcc 9 <210> 3846 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3846 Ala Thr Ser 1 <210> 3847 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3847 cagcattatg gtacctcacc tcct 24 <210> 3848 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3848 Gln His Tyr Gly Thr Ser Pro Pro 1 5 <210> 3849 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3849 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattggttat atctataata gtgggagcac caactacaac 180 ccctccctca ggagtcgact caccatttca gtagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc cacagacacg gccgtgtatc actgtgcgag aagtcattac 300 gatattttga ctggttatta taatgggtac tttgactact ggggccaggg aaccacggtc 360 accgtctcct ca 372 <210> 3850 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3850 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Asn Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Arg 50 55 60 Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Thr Asp Thr Ala Val Tyr His Cys Ala 85 90 95 Arg Ser His Tyr Asp Ile Leu Thr Gly Tyr Tyr Asn Gly Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3851 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3851 ggtggctcca tcagtagtta ctac 24 <210> 3852 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3852 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 3853 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3853 atctataata gtgggagcac c 21 <210> 3854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3854 Ile Tyr Asn Ser Gly Ser Thr 1 5 <210> 3855 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3855 gcgagaagtc attacgatat tttgactggt tattataatg ggtactttga ctac 54 <210> 3856 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3856 Ala Arg Ser His Tyr Asp Ile Leu Thr Gly Tyr Tyr Asn Gly Tyr Phe 1 5 10 15 Asp Tyr <210> 3857 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3857 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gaatattttg ttcagttcca acaataagaa ctacttagct 120 tggtaccagc agaaaccagg acagcctcct aaactactca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca atttattact gtcagcaata ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 3858 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3858 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Ile Leu Phe Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 3859 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3859 cagaatattt tgttcagttc caacaataag aactac 36 <210> 3860 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3860 Gln Asn Ile Leu Phe Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 3861 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3861 tgggcatct 9 <210> 3862 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3862 Trp Ala Ser 1 <210> 3863 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3863 cagcaatatt ataatactcc gtggacg 27 <210> 3864 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3864 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 3865 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3865 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag tatagactat 180 gcggactctg tgaagggccg attcaccgtc tccagagaca acgccaagaa ctccctgtat 240 ctgcacatga acagtctgag agttgaggac acggccttgt attactgtgc aaaagatatg 300 accttacgat ttttggagtg gttaaacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 3866 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3866 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu His Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Met Thr Leu Arg Phe Leu Glu Trp Leu Asn Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3867 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3867 ggattcacct ttgatgatta tgcc 24 <210> 3868 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3868 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 3869 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3869 attagttgga atagtggtag tata 24 <210> 3870 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3870 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 3871 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3871 gcaaaagata tgaccttacg atttttggag tggttaaacg gtatggacgt c 51 <210> 3872 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3872 Ala Lys Asp Met Thr Leu Arg Phe Leu Glu Trp Leu Asn Gly Met Asp 1 5 10 15 Val <210> 3873 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3873 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gggtgttaca agcacctact tagcctggta ccagcagaaa 120 cctggccagg ttcccaggct cctcatctat ggtgcatcca acagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcggtgta ttactgtcag caatataata actcaccgct cactttcggc 300 ggagggacca aggtggagat caaacga 327 <210> 3874 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3874 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Thr Ser Thr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3875 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3875 cagggtgtta caagcaccta c 21 <210> 3876 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3876 Gln Gly Val Thr Ser Thr Tyr 1 5 <210> 3877 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3877 ggtgcatcc 9 <210> 3878 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3878 Gly Ala Ser 1 <210> 3879 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3879 cagcaatata ataactcacc gctcact 27 <210> 3880 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3880 Gln Gln Tyr Asn Asn Ser Pro Leu Thr 1 5 <210> 3881 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3881 gaggtgcagc tggtggagtc tgggggaggg ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgacctgggt ccgccaggat 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtcataa cacatactat 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacactgtat 240 ctccaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaattgggc 300 atagtgggag atactccctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 3882 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3882 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Asp Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3883 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3883 ggattcacct ttagcagcta tgcc 24 <210> 3884 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3884 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 3885 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3885 attagtggta gtggtcataa caca 24 <210> 3886 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3886 Ile Ser Gly Ser Gly His Asn Thr 1 5 <210> 3887 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3887 gcgaaattgg gcatagtggg agatactccc tttgactac 39 <210> 3888 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3888 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr 1 5 10 <210> 3889 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3889 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcatgagc agctatttac attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatcccgtt tgcaaagtgg ggtcccatcc 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agtttcagta cccctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 3890 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3890 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3891 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3891 cagagcatga gcagctat 18 <210> 3892 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3892 Gln Ser Met Ser Ser Tyr 1 5 <210> 3893 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3893 gctgcatcc 9 <210> 3894 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3894 Ala Ala Ser 1 <210> 3895 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3895 caacagagtt tcagtacccc tccgacg 27 <210> 3896 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3896 Gln Gln Ser Phe Ser Thr Pro Pro Thr 1 5 <210> 3897 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3897 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcat cctctggatt caccctcagt agttatgaag tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatat attagcagaa gtagtagcac catatattac 180 gccgactctg tgaagggccg attcaccatc tccagagaca acgccaagaa tttattgttt 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagatcga 300 ggctacgtct ccgggggtgg tatggacgtc tggggccaag ggaccacggt caccgtctcc 360 tca 363 <210> 3898 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3898 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Glu Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Arg Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3899 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3899 ggattcaccc tcagtagtta tgaa 24 <210> 3900 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3900 Gly Phe Thr Leu Ser Ser Tyr Glu 1 5 <210> 3901 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3901 attagcagaa gtagtagcac cata 24 <210> 3902 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3902 Ile Ser Arg Ser Ser Ser Thr Ile 1 5 <210> 3903 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3903 gcgagagatc gaggctacgt ctccgggggt ggtatggacg tc 42 <210> 3904 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3904 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val 1 5 10 <210> 3905 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3905 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaatca 120 gggaaagccc ctaagatcct gatctttgct gcatccagtt tgcaaagtcg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacagtc ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3906 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3906 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Ile Leu Ile 35 40 45 Phe Ala Ala Ser Ser Leu Gln Ser Arg Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Pro Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3907 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3907 cagagcatta gcacctat 18 <210> 3908 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3908 Gln Ser Ile Ser Thr Tyr 1 5 <210> 3909 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3909 gctgcatcc 9 <210> 3910 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3910 Ala Ala Ser 1 <210> 3911 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3911 caacagactt acagtccccc attcact 27 <210> 3912 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3912 Gln Gln Thr Tyr Ser Pro Pro Phe Thr 1 5 <210> 3913 <211> 351 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3913 gaggtgcagc tggtggagtc tggagttgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg cttctggtta cacctttacc acctatggta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggatgg atcagcactt acaatggtaa cagaaattat 180 gcacagaagt tccagggcag agtcaccatg accactgaca catccacgag tacagcctac 240 atggagctga ggagcctgtc atctgacgac acggccatgt attactgtgc gagaggaagg 300 ctggatgctt ttgatatctg gggccaaggg acaatggtca ccgtctcttc a 351 <210> 3914 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3914 Glu Val Gln Leu Val Glu Ser Gly Val Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Thr Tyr Asn Gly Asn Arg Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Ser Ser Asp Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 100 105 110 Val Thr Val Ser Ser 115 <210> 3915 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3915 ggttacacct ttaccaccta tggt 24 <210> 3916 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3916 Gly Tyr Thr Phe Thr Thr Tyr Gly 1 5 <210> 3917 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3917 atcagcactt acaatggtaa caga 24 <210> 3918 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3918 Ile Ser Thr Tyr Asn Gly Asn Arg 1 5 <210> 3919 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3919 gcgagaggaa ggctggatgc ttttgatatc 30 <210> 3920 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3920 Ala Arg Gly Arg Leu Asp Ala Phe Asp Ile 1 5 10 <210> 3921 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3921 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtgtatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ttgtcaacag agttacatta cccatcctac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 3922 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3922 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Thr His Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3923 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3923 cagagcatta gcagctat 18 <210> 3924 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3924 Gln Ser Ile Ser Ser Tyr 1 5 <210> 3925 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3925 gctgcatcc 9 <210> 3926 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3926 Ala Ala Ser 1 <210> 3927 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3927 caacagagtt acattaccca tcctact 27 <210> 3928 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3928 Gln Gln Ser Tyr Ile Thr His Pro Thr 1 5 <210> 3929 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3929 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcat cctctacatt caccctcagt agttatgaag tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcatat attagtagaa gcagtaatac catatattac 180 gccgactctg tgaagggccg attcaccatc tccagagaca acgccaagaa tttactgttt 240 ctgcaaatga acagcctgag agccgacgac acggctgttt attattgtgc gagagatcga 300 ggctatgtct ccgggggtgg tatggacgtc tggggccaag ggaccacggt caccgtctcc 360 tca 363 <210> 3930 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3930 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ser Ser Thr Phe Thr Leu Ser Ser Tyr 20 25 30 Glu Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Arg Ser Ser Asn Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3931 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3931 acattcaccc tcagtagtta tgaa 24 <210> 3932 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3932 Thr Phe Thr Leu Ser Ser Tyr Glu 1 5 <210> 3933 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3933 attagtagaa gcagtaatac cata 24 <210> 3934 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3934 Ile Ser Arg Ser Ser Asn Thr Ile 1 5 <210> 3935 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3935 gcgagagatc gaggctatgt ctccgggggt ggtatggacg tc 42 <210> 3936 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3936 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val 1 5 10 <210> 3937 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3937 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ttgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagtataagt agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcaacct 240 gaagattttg caatttacta ctgtcaacag acttacagtc ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3938 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3938 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Phe Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Thr Tyr Ser Pro Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3939 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3939 cagagtataa gtagttat 18 <210> 3940 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3940 Gln Ser Ile Ser Ser Tyr 1 5 <210> 3941 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3941 gctgcatcc 9 <210> 3942 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3942 Ala Ala Ser 1 <210> 3943 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3943 caacagactt acagtccccc attcact 27 <210> 3944 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3944 Gln Gln Thr Tyr Ser Pro Pro Phe Thr 1 5 <210> 3945 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3945 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgc ctccatcagt aattactact ggacctggat ccgtcagccc 120 cccgggaagg gactagagtg gattggatat atccattata gtgggagaat taactataat 180 ccctccctca agagtcgagt caccatctca atagacacgt ccaaaaacca gttctccctg 240 aaactcagct ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag agagaggagg 300 gcactaactg gggaccttga ctactggggc cagggaagcc tggtcaccgt ctcctca 357 <210> 3946 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3946 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile His Tyr Ser Gly Arg Ile Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Glu Arg Arg Ala Leu Thr Gly Asp Leu Asp Tyr Trp Gly Gln Gly 100 105 110 Ser Leu Val Thr Val Ser Ser 115 <210> 3947 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3947 ggtgcctcca tcagtaatta ctac 24 <210> 3948 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3948 Gly Ala Ser Ile Ser Asn Tyr Tyr 1 5 <210> 3949 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3949 atccattata gtgggagaat t 21 <210> 3950 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3950 Ile His Tyr Ser Gly Arg Ile 1 5 <210> 3951 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3951 gcgagagaga ggagggcact aactggggac cttgactac 39 <210> 3952 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3952 Ala Arg Glu Arg Arg Ala Leu Thr Gly Asp Leu Asp Tyr 1 5 10 <210> 3953 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3953 gacatccaga tgacccagtc tccatcctcc ctgtctgttt ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattaga acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcggtggatc tgggacagat ttcactctca ccattggcag tctgcaacat 240 gaagattttg cgacttatta ctgtcaacag agttacaatc ccccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 3954 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3954 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln His 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Pro Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3955 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3955 cagagcatta gaacctat 18 <210> 3956 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3956 Gln Ser Ile Arg Thr Tyr 1 5 <210> 3957 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3957 gctgcatcc 9 <210> 3958 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3958 Ala Ala Ser 1 <210> 3959 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3959 caacagagtt acaatccccc gctcact 27 <210> 3960 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3960 Gln Gln Ser Tyr Asn Pro Pro Leu Thr 1 5 <210> 3961 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3961 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctttgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagttcta gtggtgttag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc 300 agctggtact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 3962 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3962 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 3963 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3963 ggattcacct ttagcacctt tgcc 24 <210> 3964 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3964 Gly Phe Thr Phe Ser Thr Phe Ala 1 5 <210> 3965 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3965 attagttcta gtggtgttag caca 24 <210> 3966 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3966 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 3967 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3967 gcgaaaggca gcagctggta ctactttgac tac 33 <210> 3968 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3968 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr 1 5 10 <210> 3969 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3969 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agtagttact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatcccg 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggtg gctcacctcc cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 3970 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3970 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3971 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3971 cagagtgtta gcagtagtta c 21 <210> 3972 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3972 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 3973 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3973 ggtgcatcc 9 <210> 3974 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3974 Gly Ala Ser 1 <210> 3975 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3975 cagcagtatg gtggctcacc tcccact 27 <210> 3976 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3976 Gln Gln Tyr Gly Gly Ser Pro Pro Thr 1 5 <210> 3977 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3977 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcat cctctggatt caccctcagt agttatgaag tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatac attagtagaa gtagtagcac catatattac 180 ggcgactctg tgaagggccg attcaccatt tccagagaca acgccaagaa ctcactgttt 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagatcga 300 ggctacgtct ccgggggtgg tatggacgtc tggggccaag ggaccacggt caccgtctcc 360 tca 363 <210> 3978 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3978 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Glu Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Arg Ser Ser Ser Thr Ile Tyr Tyr Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3979 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3979 ggattcaccc tcagtagtta tgaa 24 <210> 3980 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3980 Gly Phe Thr Leu Ser Ser Tyr Glu 1 5 <210> 3981 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3981 attagtagaa gtagtagcac cata 24 <210> 3982 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3982 Ile Ser Arg Ser Ser Ser Thr Ile 1 5 <210> 3983 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3983 gcgagagatc gaggctacgt ctccgggggt ggtatggacg tc 42 <210> 3984 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3984 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val 1 5 10 <210> 3985 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3985 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagatcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacagtc ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 3986 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3986 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 35 40 45 Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Pro Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 3987 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3987 cagagcatta gcagctat 18 <210> 3988 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3988 Gln Ser Ile Ser Ser Tyr 1 5 <210> 3989 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3989 gctgcatcc 9 <210> 3990 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3990 Ala Ala Ser 1 <210> 3991 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3991 caacagactt acagtccccc attcact 27 <210> 3992 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3992 Gln Gln Thr Tyr Ser Pro Pro Phe Thr 1 5 <210> 3993 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3993 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agtaattact ggaactggat ccggcagtcc 120 ccagggaagg gactggaatg gattggatat atctttcaca ctggacgcac caactacagc 180 ccctccctca agagtcgagt caccacatca gtagacacgt ccaagaacca gttctccctg 240 aagctgactt ctgtgaccgc cgcagacacg gccgtgtatt actgtgtgag agagaggagg 300 gcactaactg gggactttga ctactggggc cagggaacca cggtcaccgt ctcctca 357 <210> 3994 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3994 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asn 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Phe His Thr Gly Arg Thr Asn Tyr Ser Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Thr Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Glu Arg Arg Ala Leu Thr Gly Asp Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 3995 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3995 ggtggctcca tcagtagtaa ttac 24 <210> 3996 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3996 Gly Gly Ser Ile Ser Ser Asn Tyr 1 5 <210> 3997 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3997 atctttcaca ctggacgcac c 21 <210> 3998 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 3998 Ile Phe His Thr Gly Arg Thr 1 5 <210> 3999 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 3999 gtgagagaga ggagggcact aactggggac tttgactac 39 <210> 4000 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4000 Val Arg Glu Arg Arg Ala Leu Thr Gly Asp Phe Asp Tyr 1 5 10 <210> 4001 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4001 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcaagtca gagcattagc aggtatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct acatccactt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttt caacttacta ctgtcagcag agttacagta tcccggtcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4002 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4002 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ser Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Val 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4003 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4003 cagagcatta gcaggtat 18 <210> 4004 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4004 Gln Ser Ile Ser Arg Tyr 1 5 <210> 4005 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4005 gctacatcc 9 <210> 4006 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4006 Ala Thr Ser 1 <210> 4007 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4007 cagcagagtt acagtatccc ggtcact 27 <210> 4008 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4008 Gln Gln Ser Tyr Ser Ile Pro Val Thr 1 5 <210> 4009 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4009 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgtactg tctatggtgg gtccttcaat tattactact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaat 180 ccgtccctca agagtcgagt caccatatca gtagacacgc ccaagaacca gttctccctg 240 aaattgaact ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag aggccgaata 300 acagcagctg tctctgatgc ttttgatatc tggggccaag ggacaatggt caccgtctcc 360 tca 363 <210> 4010 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4010 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Tyr Gly Gly Ser Phe Asn Tyr Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Pro Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Ile Thr Ala Ala Val Ser Asp Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 4011 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4011 ggtgggtcct tcaattatta ctac 24 <210> 4012 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4012 Gly Gly Ser Phe Asn Tyr Tyr Tyr 1 5 <210> 4013 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4013 atcaatcata gtggaagcac c 21 <210> 4014 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4014 Ile Asn His Ser Gly Ser Thr 1 5 <210> 4015 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4015 gcgagaggcc gaataacagc agctgtctct gatgcttttg atatc 45 <210> 4016 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4016 Ala Arg Gly Arg Ile Thr Ala Ala Val Ser Asp Ala Phe Asp Ile 1 5 10 15 <210> 4017 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4017 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat agtacatccg acagggccac tggcatccca 180 gacagattca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggtg acagattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 4018 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4018 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Ser Thr Ser Asp Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Arg Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4019 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4019 cagagtgtta gcagcagcta c 21 <210> 4020 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4020 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 4021 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4021 agtacatcc 9 <210> 4022 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4022 Ser Thr Ser 1 <210> 4023 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4023 cagcagtatg gtgacagatt catt 24 <210> 4024 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4024 Gln Gln Tyr Gly Asp Arg Phe Ile 1 5 <210> 4025 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4025 caggtgcagc tgctgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcaac tattactact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaat 180 ccgtccctca agagtcgagt caccatatca gtagacacgc ccaagaacca gttctccctg 240 aaattgagct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag aggccgaata 300 acagcagctg tctctgatgc ttttgatatc tggggccaag ggacaatggt caccgtctct 360 tca 363 <210> 4026 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4026 Gln Val Gln Leu Leu Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Tyr Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Pro Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Ile Thr Ala Ala Val Ser Asp Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 4027 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4027 ggtgggtcct tcaactatta ctac 24 <210> 4028 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4028 Gly Gly Ser Phe Asn Tyr Tyr Tyr 1 5 <210> 4029 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4029 atcaatcata gtggaagcac c 21 <210> 4030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4030 Ile Asn His Ser Gly Ser Thr 1 5 <210> 4031 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4031 gcgagaggcc gaataacagc agctgtctct gatgcttttg atatc 45 <210> 4032 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4032 Ala Arg Gly Arg Ile Thr Ala Ala Val Ser Asp Ala Phe Asp Ile 1 5 10 15 <210> 4033 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4033 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagttact tagcctggta ccaacagaaa 120 cctggccagg ctcccaggct cctcatctat ggtacatccg acagggccac tggcatccca 180 gacagattca gtggcagtgg gtccgggaca gaattcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtttgatg acagattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 4034 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4034 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Asp Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Asp Arg Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4035 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4035 cagagtgtta gcagcagtta c 21 <210> 4036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4036 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 4037 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4037 ggtacatcc 9 <210> 4038 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4038 Gly Thr Ser 1 <210> 4039 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4039 cagcagtttg atgacagatt catt 24 <210> 4040 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4040 Gln Gln Phe Asp Asp Arg Phe Ile 1 5 <210> 4041 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4041 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtcataa cacatactat 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacactgtat 240 ctccaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaattgggc 300 atagtgggag atactccctt tgactactgg ggccagggaa ccatggtcac cgtctcctca 360 <210> 4042 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4042 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 4043 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4043 ggattcacct ttagcaccta tgcc 24 <210> 4044 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4044 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 4045 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4045 attagtggta gtggtcataa caca 24 <210> 4046 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4046 Ile Ser Gly Ser Gly His Asn Thr 1 5 <210> 4047 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4047 gcgaaattgg gcatagtggg agatactccc tttgactac 39 <210> 4048 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4048 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr 1 5 10 <210> 4049 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4049 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcatgagc agctatttac attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatcccgtt tgcaaggtgg ggtcccatcc 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg catcttacta ctgtcaacag agtttcagta cccctccgac gttcggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4050 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4050 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4051 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4051 cagagcatga gcagctat 18 <210> 4052 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4052 Gln Ser Met Ser Ser Tyr 1 5 <210> 4053 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4053 gctgcatcc 9 <210> 4054 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4054 Ala Ala Ser 1 <210> 4055 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4055 caacagagtt tcagtacccc tccgacg 27 <210> 4056 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4056 Gln Gln Ser Phe Ser Thr Pro Pro Thr 1 5 <210> 4057 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4057 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctttgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagttcta gtggtgttag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc 300 agctggtact actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 4058 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4058 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 4059 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4059 ggattcacct ttagcacctt tgcc 24 <210> 4060 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4060 Gly Phe Thr Phe Ser Thr Phe Ala 1 5 <210> 4061 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4061 attagttcta gtggtgttag caca 24 <210> 4062 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4062 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 4063 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4063 gcgaaaggca gcagctggta ctactttgac tac 33 <210> 4064 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4064 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr 1 5 10 <210> 4065 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4065 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agtagttact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatcccg 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggtg gctcacctcc cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 4066 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4066 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4067 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4067 cagagtgtta gcagtagtta c 21 <210> 4068 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4068 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 4069 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4069 ggtgcatcc 9 <210> 4070 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4070 Gly Ala Ser 1 <210> 4071 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4071 cagcagtatg gtggctcacc tcccact 27 <210> 4072 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4072 Gln Gln Tyr Gly Gly Ser Pro Pro Thr 1 5 <210> 4073 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4073 caggtgcagc tggtggagtc tgggggaggc ttggtacagt cgggggggtc cctgagactc 60 tcctgtgaag cctctggatt cacctttatc aactatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attgacgtta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaaaaa cacactatat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccccac 300 tccctacgat ttgtggagtg gtccttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 4074 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4074 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ile Asn Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Asp Val Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro His Ser Leu Arg Phe Val Glu Trp Ser Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4075 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4075 ggattcacct ttatcaacta tgcc 24 <210> 4076 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4076 Gly Phe Thr Phe Ile Asn Tyr Ala 1 5 <210> 4077 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4077 attgacgtta gtggtggtag caca 24 <210> 4078 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4078 Ile Asp Val Ser Gly Gly Ser Thr 1 5 <210> 4079 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4079 gcgaaacccc actccctacg atttgtggag tggtccttgg acgtc 45 <210> 4080 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4080 Ala Lys Pro His Ser Leu Arg Phe Val Glu Trp Ser Leu Asp Val 1 5 10 15 <210> 4081 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4081 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatgtga gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatcccgtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactc ctgtctacag agttacggta accctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4082 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4082 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Ser Cys Leu Gln Ser Tyr Gly Asn Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4083 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4083 cagagcatta gcagctat 18 <210> 4084 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4084 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4085 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4085 gctgcatcc 9 <210> 4086 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4086 Ala Ala Ser 1 <210> 4087 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4087 ctacagagtt acggtaaccc tccgacg 27 <210> 4088 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4088 Leu Gln Ser Tyr Gly Asn Pro Pro Thr 1 5 <210> 4089 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4089 gaggtgcagc tggtggagtc tgggggaggg ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgacctgggt ccgccaggat 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtcataa cacatactat 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacactgtat 240 ctccaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaattgggc 300 atagtgggag atactccctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 4090 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4090 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Asp Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly His Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4091 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4091 ggattcacct ttagcagcta tgcc 24 <210> 4092 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4092 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 4093 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4093 attagtggta gtggtcataa caca 24 <210> 4094 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4094 Ile Ser Gly Ser Gly His Asn Thr 1 5 <210> 4095 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4095 gcgaaattgg gcatagtggg agatactccc tttgactac 39 <210> 4096 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4096 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr 1 5 10 <210> 4097 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4097 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcatgagc agctatttac attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatcccgtt tgcaaagtgg ggtcccatcc 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agtttcagta cccctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4098 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4098 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4099 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4099 cagagcatga gcagctat 18 <210> 4100 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4100 Gln Ser Met Ser Ser Tyr 1 5 <210> 4101 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4101 gctgcatcc 9 <210> 4102 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4102 Ala Ala Ser 1 <210> 4103 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4103 caacagagtt tcagtacccc tccgacg 27 <210> 4104 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4104 Gln Gln Ser Phe Ser Thr Pro Pro Thr 1 5 <210> 4105 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4105 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt catctttagc agctatgcca taacctgggt ccgccaggct 120 ccagggacgg ggctggagtg ggtctcagct ataagtggta ctggtcagaa cacatactat 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cattctgtat 240 ctccaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaattgggc 300 atagtgggag atactccctt tgactactgg ggccagggaa ccacggtcac cgtctcctca 360 <210> 4106 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4106 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Thr Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Thr Gly Gln Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ile Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4107 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4107 ggattcatct ttagcagcta tgcc 24 <210> 4108 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4108 Gly Phe Ile Phe Ser Ser Tyr Ala 1 5 <210> 4109 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4109 ataagtggta ctggtcagaa caca 24 <210> 4110 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4110 Ile Ser Gly Thr Gly Gln Asn Thr 1 5 <210> 4111 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4111 gcgaaattgg gcatagtggg agatactccc tttgactac 39 <210> 4112 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4112 Ala Lys Leu Gly Ile Val Gly Asp Thr Pro Phe Asp Tyr 1 5 10 <210> 4113 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4113 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcatgagc agctatttac attggtatca gcagagacca 120 gggaaagccc ctaagctcct gatctattct gcatccagtt tgcagagtgg ggtcccatcc 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaggattttg caacttacta ctgtcaacag agttacagta cccctccgac gttcggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4114 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4114 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4115 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4115 cagagcatga gcagctat 18 <210> 4116 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4116 Gln Ser Met Ser Ser Tyr 1 5 <210> 4117 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4117 tctgcatcc 9 <210> 4118 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4118 Ser Ala Ser 1 <210> 4119 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4119 caacagagtt acagtacccc tccgacg 27 <210> 4120 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4120 Gln Gln Ser Tyr Ser Thr Pro Pro Thr 1 5 <210> 4121 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4121 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcacta tctctggtgg ctccatcagt agttactact ggagctggat ccggctgccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaacac caactacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aaactgagct ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag agggaaagca 300 gcagctgact actactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 4122 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4122 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Leu Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Lys Ala Ala Ala Asp Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4123 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4123 ggtggctcca tcagtagtta ctac 24 <210> 4124 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4124 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 4125 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4125 atctattaca gtgggaacac c 21 <210> 4126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4126 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 4127 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4127 gcgagaggga aagcagcagc tgactactac tactacggta tggacgtc 48 <210> 4128 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4128 Ala Arg Gly Lys Ala Ala Ala Asp Tyr Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4129 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4129 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gagtgttttt tacagttcca acaataagaa ctacttagct 120 tggtaccagc agaaaccagg acagactcct aagctactca tttactgggc atctacccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 4130 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4130 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Thr Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 4131 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4131 cagagtgttt tttacagttc caacaataag aactac 36 <210> 4132 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4132 Gln Ser Val Phe Tyr Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 4133 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4133 tgggcatct 9 <210> 4134 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4134 Trp Ala Ser 1 <210> 4135 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4135 cagcaatatt ataatactcc gtggacg 27 <210> 4136 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4136 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 4137 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4137 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcat cctctggatt caccctcagt agttatgaag tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatac attagtagaa gtagtaccac catatattac 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agtcgaggac acggctgttt attactgtgc gagagatcga 300 ggctacgtct ccgggggtgg tatggacgtc tggggccaag ggaccacggt caccgtctcc 360 tca 363 <210> 4138 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4138 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Phe Thr Leu Ser Ser Tyr 20 25 30 Glu Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Arg Ser Ser Thr Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4139 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4139 ggattcaccc tcagtagtta tgaa 24 <210> 4140 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4140 Gly Phe Thr Leu Ser Ser Tyr Glu 1 5 <210> 4141 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4141 attagtagaa gtagtaccac cata 24 <210> 4142 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4142 Ile Ser Arg Ser Ser Thr Thr Ile 1 5 <210> 4143 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4143 gcgagagatc gaggctacgt ctccgggggt ggtatggacg tc 42 <210> 4144 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4144 Ala Arg Asp Arg Gly Tyr Val Ser Gly Gly Gly Met Asp Val 1 5 10 <210> 4145 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4145 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagatcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacaata cccccttcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 4146 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4146 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 35 40 45 Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Asn Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4147 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4147 cagagcatta gcagctat 18 <210> 4148 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4148 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4149 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4149 gctgcatcc 9 <210> 4150 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4150 Ala Ala Ser 1 <210> 4151 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4151 caacagactt acaatacccc cttcact 27 <210> 4152 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4152 Gln Gln Thr Tyr Asn Thr Pro Phe Thr 1 5 <210> 4153 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4153 gaggtgcagc tggtggagtc tgggggaggc ttggtccaga ctggggggtc cctgagactc 60 tcctgttcag cctctggatt cacctttagt ggctattgga tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtgggcaac ataaaacaag atggaagtga gaaatactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agtcgaggac acggctattt attactgtgc gagagatcat 300 atagtgggag ctccttactt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 4154 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4154 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Asp His Ile Val Gly Ala Pro Tyr Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4155 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4155 ggattcacct ttagtggcta ttgg 24 <210> 4156 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4156 Gly Phe Thr Phe Ser Gly Tyr Trp 1 5 <210> 4157 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4157 ataaaacaag atggaagtga gaaa 24 <210> 4158 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4158 Ile Lys Gln Asp Gly Ser Glu Lys 1 5 <210> 4159 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4159 gcgagagatc atatagtggg agctccttac tttgactac 39 <210> 4160 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4160 Ala Arg Asp His Ile Val Gly Ala Pro Tyr Phe Asp Tyr 1 5 10 <210> 4161 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4161 gacatcctga tgacccagtc tccaacctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcaagtca gagtattagc tactatttaa attggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 ggagattttg caacttacta ctgtcagcag agttacagta tccctccgga ctacactttt 300 ggccagggga ccaaggtgga gatcaaacga 330 <210> 4162 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4162 Asp Ile Leu Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Gly Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Asp Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 <210> 4163 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4163 cagagtatta gctactat 18 <210> 4164 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4164 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 4165 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4165 gctgcatcc 9 <210> 4166 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4166 Ala Ala Ser 1 <210> 4167 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4167 cagcagagtt acagtatccc tccggactac act 33 <210> 4168 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4168 Gln Gln Ser Tyr Ser Ile Pro Pro Asp Tyr Thr 1 5 10 <210> 4169 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4169 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cttgagactc 60 tcctgtgcag cctctggatt caccttggat gattatggca tgcattgggt ccggcaagct 120 ccagggaagg gcctggaatg ggtctcaggt attagttgga atagtggtag tttagactat 180 gcggactctg tgaaggggcg attcaccatc tccagagaca acgccaagaa ctccctgttt 240 ctgcaaatga acagtctgag acctgaggac acggccttgt atttctgtgt aaaagataga 300 gcagtgacta cggaagaaga tttccactat ctcttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 4170 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4170 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Leu Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Val Lys Asp Arg Ala Val Thr Thr Glu Glu Asp Phe His Tyr Leu Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4171 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4171 ggattcacct tggatgatta tggc 24 <210> 4172 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4172 Gly Phe Thr Leu Asp Asp Tyr Gly 1 5 <210> 4173 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4173 attagttgga atagtggtag ttta 24 <210> 4174 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4174 Ile Ser Trp Asn Ser Gly Ser Leu 1 5 <210> 4175 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4175 gtaaaagata gagcagtgac tacggaagaa gatttccact atctcttcgg tatggacgtc 60 <210> 4176 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4176 Val Lys Asp Arg Ala Val Thr Thr Glu Glu Asp Phe His Tyr Leu Phe 1 5 10 15 Gly Met Asp Val 20 <210> 4177 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4177 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattaac tggtatttaa attggtatca acagaaacca 120 gggaaagccc ctaaactcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcagcag agtttcagta cccctctcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4178 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4178 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Trp Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4179 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4179 cagagcatta actggtat 18 <210> 4180 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4180 Gln Ser Ile Asn Trp Tyr 1 5 <210> 4181 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4181 actgcatcc 9 <210> 4182 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4182 Thr Ala Ser 1 <210> 4183 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4183 cagcagagtt tcagtacccc tctcact 27 <210> 4184 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4184 Gln Gln Ser Phe Ser Thr Pro Leu Thr 1 5 <210> 4185 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4185 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatac ataagtagta gtggtagtaa catatactac 180 gcagactctg tgaagggccg atttaccatc tccagagaca acgccaagaa ctcattgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagatcgg 300 gagggagcta cgggggactg gttcgacccc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 4186 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4186 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Glu Gly Ala Thr Gly Asp Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4187 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4187 ggattcacct tcagtagtta tgaa 24 <210> 4188 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4188 Gly Phe Thr Phe Ser Ser Tyr Glu 1 5 <210> 4189 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4189 ataagtagta gtggtagtaa cata 24 <210> 4190 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4190 Ile Ser Ser Ser Gly Ser Asn Ile 1 5 <210> 4191 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4191 gcgagagatc gggagggagc tacgggggac tggttcgacc cc 42 <210> 4192 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4192 Ala Arg Asp Arg Glu Gly Ala Thr Gly Asp Trp Phe Asp Pro 1 5 10 <210> 4193 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4193 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaaaag tatgataatc tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4194 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4194 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Asn Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4195 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4195 caggacatta gcaactat 18 <210> 4196 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4196 Gln Asp Ile Ser Asn Tyr 1 5 <210> 4197 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4197 gatgcatcc 9 <210> 4198 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4198 Asp Ala Ser 1 <210> 4199 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4199 caaaagtatg ataatctccc gtacact 27 <210> 4200 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4200 Gln Lys Tyr Asp Asn Leu Pro Tyr Thr 1 5 <210> 4201 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4201 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cttgagactc 60 tcctgtgcag cctctggatt caccttggat gattatggca tgcattgggt ccggcaagct 120 ccagggaagg gcctggaatg ggtctcaggt attagttgga atagtggtag tttagactat 180 gcggactctg tgaaggggcg attcaccatc tccagagaca acgccaagaa ctccctgttt 240 ctgcaaatga acagtctgag acctgaggac acggccttgt atttctgtgt aaaagataga 300 gcagtgacta cggaagaaga tttccactat ctcttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 4202 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4202 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Leu Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Val Lys Asp Arg Ala Val Thr Thr Glu Glu Asp Phe His Tyr Leu Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4203 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4203 ggattcacct tggatgatta tggc 24 <210> 4204 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4204 Gly Phe Thr Leu Asp Asp Tyr Gly 1 5 <210> 4205 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4205 attagttgga atagtggtag ttta 24 <210> 4206 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4206 Ile Ser Trp Asn Ser Gly Ser Leu 1 5 <210> 4207 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4207 gtaaaagata gagcagtgac tacggaagaa gatttccact atctcttcgg tatggacgtc 60 <210> 4208 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4208 Val Lys Asp Arg Ala Val Thr Thr Glu Glu Asp Phe His Tyr Leu Phe 1 5 10 15 Gly Met Asp Val 20 <210> 4209 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4209 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattaac tggtatttaa attggtatca acagaaacca 120 gggaaagccc ctaaactcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcagcag agtttcagta cccctctcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4210 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4210 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Trp Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4211 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4211 cagagcatta actggtat 18 <210> 4212 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4212 Gln Ser Ile Asn Trp Tyr 1 5 <210> 4213 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4213 actgcatcc 9 <210> 4214 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4214 Thr Ala Ser 1 <210> 4215 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4215 cagcagagtt tcagtacccc tctcact 27 <210> 4216 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4216 Gln Gln Ser Phe Ser Thr Pro Leu Thr 1 5 <210> 4217 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4217 caggtgcagc tggtggagtc tgggggaggc ttggtacagt ttggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgacgac acggccgtat attactgtgc gaagatagca 300 gtgactggta cgtccccctt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 4218 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4218 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Phe Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Ala Val Thr Gly Thr Ser Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4219 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4219 ggattcacct ttagcagcta tgcc 24 <210> 4220 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4220 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 4221 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4221 attagtggta gtggtggtag caca 24 <210> 4222 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4222 Ile Ser Gly Ser Gly Gly Ser Thr 1 5 <210> 4223 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4223 gcgaagatag cagtgactgg tacgtccccc tttgactac 39 <210> 4224 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4224 Ala Lys Ile Ala Val Thr Gly Thr Ser Pro Phe Asp Tyr 1 5 10 <210> 4225 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4225 gacatccaga tgacccagtc tccatcctcc ctgtcttcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc tcctatttaa actggtatca gaagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaacgtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacaaat ttcactctca ccatcagcag tctgcaacct 240 gaatattttg caacttacta ctgtcaacag acttacacta cccctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4226 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4226 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ser Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Tyr Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Thr Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4227 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4227 cagagcatta gctcctat 18 <210> 4228 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4228 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4229 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4229 gctgcatcc 9 <210> 4230 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4230 Ala Ala Ser 1 <210> 4231 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4231 caacagactt acactacccc tccgacg 27 <210> 4232 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4232 Gln Gln Thr Tyr Thr Thr Pro Pro Thr 1 5 <210> 4233 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4233 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgaca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cttaggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaataa ctccctgtat 240 ctgcaaatga acagtctgag acctgaggac acggccctgt attactgtgc gaaacataga 300 acagtaacta cggaagagat tttctactac tactttggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 4234 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4234 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Leu Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys His Arg Thr Val Thr Thr Glu Glu Ile Phe Tyr Tyr Tyr Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4235 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4235 ggattcacct ttgatgatta tgac 24 <210> 4236 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4236 Gly Phe Thr Phe Asp Asp Tyr Asp 1 5 <210> 4237 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4237 attagttgga atagtggtag ctta 24 <210> 4238 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4238 Ile Ser Trp Asn Ser Gly Ser Leu 1 5 <210> 4239 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4239 gcgaaacata gaacagtaac tacggaagag attttctact actactttgg tatggacgtc 60 <210> 4240 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4240 Ala Lys His Arg Thr Val Thr Thr Glu Glu Ile Phe Tyr Tyr Tyr Phe 1 5 10 15 Gly Met Asp Val 20 <210> 4241 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4241 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 ttcacttgcc gggcaagtca gagcattggc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctattct gcatccagtt tgcaaagtgg ggtcccatca 180 agattcagtg gcagtggatc tgggacagat ttcagtctca ccatcagcag tctgcagcct 240 gaagattttg caacttacta ctgtcaacag agtttcaatg tccctcccac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4242 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4242 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Asn Val Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4243 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4243 cagagcattg gcaactat 18 <210> 4244 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4244 Gln Ser Ile Gly Asn Tyr 1 5 <210> 4245 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4245 tctgcatcc 9 <210> 4246 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4246 Ser Ala Ser 1 <210> 4247 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4247 caacagagtt tcaatgtccc tcccact 27 <210> 4248 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4248 Gln Gln Ser Phe Asn Val Pro Pro Thr 1 5 <210> 4249 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4249 gaggtgcagc tggtggagtc tgggggaggt gtggttcggc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgacc tgatctgggt ccgccaagct 120 ccagggaagg ggctggagtg ggtctctggt attaattgga atggcgaaat cacaggttat 180 gcagactctg tgaagggccg attcaccata tccagagaca aagccaagaa ctccctgtat 240 ctgcaaatgc acagtctgag agccgaggat tcggccttgt atttttgtgc gagagaagga 300 tgtagtagta ccagctgctt tccatattac tacccctact tcggtatgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 4250 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4250 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Asp Leu Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Glu Ile Thr Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met His Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Cys Ser Ser Thr Ser Cys Phe Pro Tyr Tyr Tyr Pro 100 105 110 Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 4251 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4251 ggattcacct ttgatgatta tgac 24 <210> 4252 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4252 Gly Phe Thr Phe Asp Asp Tyr Asp 1 5 <210> 4253 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4253 attaattgga atggcgaaat caca 24 <210> 4254 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4254 Ile Asn Trp Asn Gly Glu Ile Thr 1 5 <210> 4255 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4255 gcgagagaag gatgtagtag taccagctgc tttccatatt actaccccta cttcggtatg 60 gacgtc 66 <210> 4256 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4256 Ala Arg Glu Gly Cys Ser Ser Thr Ser Cys Phe Pro Tyr Tyr Tyr Pro 1 5 10 15 Tyr Phe Gly Met Asp Val 20 <210> 4257 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4257 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgta ggtctagtca gagcctcctg catagtaatg gagacaacta tttggattgg 120 tacctacaga agccagggca gtctccacaa ctcctgatct ttttgaattc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggta cagattttac actgaaaatc 240 aacacagtgg aggctgagga tgttgggatt tattactgca tgcaggctct acaaactccg 300 tggacgttcg gccaagggac caaggtggag atcaaacga 339 <210> 4258 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4258 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Asp Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Phe Leu Asn Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Asn Thr Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 4259 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4259 cagagcctcc tgcatagtaa tggagacaac tat 33 <210> 4260 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4260 Gln Ser Leu Leu His Ser Asn Gly Asp Asn Tyr 1 5 10 <210> 4261 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4261 ttgaattct 9 <210> 4262 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4262 Leu Asn Ser 1 <210> 4263 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4263 atgcaggctc tacaaactcc gtggacg 27 <210> 4264 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4264 Met Gln Ala Leu Gln Thr Pro Trp Thr 1 5 <210> 4265 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4265 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggagtc cctgagactc 60 tcctgtgcag cctctggatt catctttagt acctattgga tgaactgggt ccgtcaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaagtactat 180 gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtct 240 ctgcaaatga gtagcctgag agccgaggac acggctgttt attactgtgc gagagatcat 300 attgtgggag ctccttactt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 <210> 4266 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4266 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Thr Tyr 20 25 30 Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp His Ile Val Gly Ala Pro Tyr Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4267 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4267 ggattcatct ttagtaccta ttgg 24 <210> 4268 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4268 Gly Phe Ile Phe Ser Thr Tyr Trp 1 5 <210> 4269 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4269 ataaagcaag atggaagtga gaag 24 <210> 4270 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4270 Ile Lys Gln Asp Gly Ser Glu Lys 1 5 <210> 4271 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4271 gcgagagatc atattgtggg agctccttac tttgactac 39 <210> 4272 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4272 Ala Arg Asp His Ile Val Gly Ala Pro Tyr Phe Asp Tyr 1 5 10 <210> 4273 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4273 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagt tactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg taatttacta ctgtcaacag agttacagta tccctccgga gtacactttt 300 ggccagggga ccaaggtgga gatcaaacga 330 <210> 4274 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4274 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Val Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Glu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 <210> 4275 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4275 cagagcatta gttactat 18 <210> 4276 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4276 Gln Ser Ile Ser Tyr Tyr 1 5 <210> 4277 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4277 ggtgcatcc 9 <210> 4278 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4278 Gly Ala Ser 1 <210> 4279 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4279 caacagagtt acagtatccc tccggagtac act 33 <210> 4280 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4280 Gln Gln Ser Tyr Ser Ile Pro Pro Glu Tyr Thr 1 5 10 <210> 4281 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4281 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcacta tctctggtgg ctccatcagt acttactact ggaactggat ccggcagccc 120 ccagggaagg gactggaatg gattgggcat atcttttata gtgggaccac caactacaac 180 ccctccctca ggagtcgagt caccatatca gtagacacgt ccaagaatca gttatccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccttttatt cctgtgcgag agagaggggc 300 ggggtaaccg acggtgacta cggcgggttc gacccctggg gccagggaac cctggtcacc 360 gtctcctca 369 <210> 4282 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4282 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly His Ile Phe Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Arg 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Phe Tyr Ser Cys Ala 85 90 95 Arg Glu Arg Gly Gly Val Thr Asp Gly Asp Tyr Gly Gly Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4283 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4283 ggtggctcca tcagtactta ctac 24 <210> 4284 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4284 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 4285 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4285 atcttttata gtgggaccac c 21 <210> 4286 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4286 Ile Phe Tyr Ser Gly Thr Thr 1 5 <210> 4287 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4287 gcgagagaga ggggcggggt aaccgacggt gactacggcg ggttcgaccc c 51 <210> 4288 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4288 Ala Arg Glu Arg Gly Gly Val Thr Asp Gly Asp Tyr Gly Gly Phe Asp 1 5 10 15 Pro <210> 4289 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4289 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcagt 60 atcacttgcc gggcaagtca gatcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagtg cccctcggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4290 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4290 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ile Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4291 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4291 cagatcatta gcacctat 18 <210> 4292 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4292 Gln Ile Ile Ser Thr Tyr 1 5 <210> 4293 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4293 gctgcatcc 9 <210> 4294 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4294 Ala Ala Ser 1 <210> 4295 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4295 caacagagtt acagtgcccc tcggacg 27 <210> 4296 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4296 Gln Gln Ser Tyr Ser Ala Pro Arg Thr 1 5 <210> 4297 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4297 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaactggat ccggcagtcc 120 ccagggaagg gactggagtg gattgggaat atcaattaca gtgggagtac caactacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaggaacca gttctccctg 240 aagttgagtt ttgtgaccgc tgcggacacg gccgtgtttt tctgtgcgag agagaggggc 300 gggtttaccg acactgacta cggcggattc gacccctggg gccagggaac cctggtcacc 360 gtctcctca 369 <210> 4298 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4298 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Phe Val Thr Ala Ala Asp Thr Ala Val Phe Phe Cys Ala 85 90 95 Arg Glu Arg Gly Gly Phe Thr Asp Thr Asp Tyr Gly Gly Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4299 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4299 ggtggctcca tcagtactta ctac 24 <210> 4300 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4300 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 4301 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4301 atcaattaca gtgggagtac c 21 <210> 4302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4302 Ile Asn Tyr Ser Gly Ser Thr 1 5 <210> 4303 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4303 gcgagagaga ggggcgggtt taccgacact gactacggcg gattcgaccc c 51 <210> 4304 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4304 Ala Arg Glu Arg Gly Gly Phe Thr Asp Thr Asp Tyr Gly Gly Phe Asp 1 5 10 15 Pro <210> 4305 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4305 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtctcc 60 atcacttgcc gggcaagtca gagcattagt agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctcggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4306 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4306 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4307 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4307 cagagcatta gtagttat 18 <210> 4308 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4308 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4309 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4309 gctgcatcc 9 <210> 4310 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4310 Ala Ala Ser 1 <210> 4311 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4311 caacagagtt acagtacccc tcggacg 27 <210> 4312 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4312 Gln Gln Ser Tyr Ser Thr Pro Arg Thr 1 5 <210> 4313 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4313 gaggtgcagc tggtggagtc tgggggaggt gtggtacggc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgct gattatgaca tgacctgggt ccgccaagct 120 ccagggaagg ggctggaatg ggtctctggt attaattgga atggtgatat cacaggttat 180 gcagactctg tgaggggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agccgaggac acggccttat atcactgtgc gagagaggga 300 tgtagtagta ccagctgctt tccatattac tatccctact tcggtttgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 4314 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4314 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Asp Ile Thr Gly Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 85 90 95 Ala Arg Glu Gly Cys Ser Ser Thr Ser Cys Phe Pro Tyr Tyr Tyr Pro 100 105 110 Tyr Phe Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 4315 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4315 ggattcacct ttgctgatta tgac 24 <210> 4316 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4316 Gly Phe Thr Phe Ala Asp Tyr Asp 1 5 <210> 4317 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4317 attaattgga atggtgatat caca 24 <210> 4318 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4318 Ile Asn Trp Asn Gly Asp Ile Thr 1 5 <210> 4319 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4319 gcgagagagg gatgtagtag taccagctgc tttccatatt actatcccta cttcggtttg 60 gacgtc 66 <210> 4320 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4320 Ala Arg Glu Gly Cys Ser Ser Thr Ser Cys Phe Pro Tyr Tyr Tyr Pro 1 5 10 15 Tyr Phe Gly Leu Asp Val 20 <210> 4321 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4321 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4322 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4322 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4323 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4323 cagagcatta gcagctat 18 <210> 4324 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4324 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4325 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4325 gctgcatcc 9 <210> 4326 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4326 Ala Ala Ser 1 <210> 4327 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4327 caacagagtt acagtacccc gctcact 27 <210> 4328 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4328 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 4329 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4329 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc acctatgcca taacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtaa cacatactac 180 gcagacttcg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gactctggat 300 atagtggcta cgtcccatgc ttttgatatc tggggccaag ggacaatggt caccgtctct 360 tca 363 <210> 4330 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4330 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Phe Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Leu Asp Ile Val Ala Thr Ser His Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 4331 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4331 ggattcacct ttagcaccta tgcc 24 <210> 4332 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4332 Gly Phe Thr Phe Ser Thr Tyr Ala 1 5 <210> 4333 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4333 attagtggta gtggtggtaa caca 24 <210> 4334 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4334 Ile Ser Gly Ser Gly Gly Asn Thr 1 5 <210> 4335 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4335 gcgactctgg atatagtggc tacgtcccat gcttttgata tc 42 <210> 4336 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4336 Ala Thr Leu Asp Ile Val Ala Thr Ser His Ala Phe Asp Ile 1 5 10 <210> 4337 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4337 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc acctatttac attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcaatggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4338 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4338 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Asn Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4339 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4339 cagagcatta gcacctat 18 <210> 4340 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4340 Gln Ser Ile Ser Thr Tyr 1 5 <210> 4341 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4341 gctgcatcc 9 <210> 4342 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4342 Ala Ala Ser 1 <210> 4343 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4343 caacagagtt acagtacccc tcccact 27 <210> 4344 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4344 Gln Gln Ser Tyr Ser Thr Pro Pro Thr 1 5 <210> 4345 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4345 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cttgagactc 60 tcctgtgcag cctctggatt caccttggat gattatggca tgcattgggt ccggcaagct 120 ccagggaagg gcctggaatg ggtctcaggt attagttgga atagtggtag tttagactat 180 gcggactctg tgaaggggcg attcaccatc tccagagaca acgccaagaa ctccctgttt 240 ctgcaaatga acagtctgag acctgaggac acggccttgt atttctgtgt aaaagataga 300 gcagtgacta cggaagaaga tttccactat ctcttcggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 4346 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4346 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Leu Asp Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Val Lys Asp Arg Ala Val Thr Thr Glu Glu Asp Phe His Tyr Leu Phe 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4347 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4347 ggattcacct tggatgatta tggc 24 <210> 4348 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4348 Gly Phe Thr Leu Asp Asp Tyr Gly 1 5 <210> 4349 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4349 attagttgga atagtggtag ttta 24 <210> 4350 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4350 Ile Ser Trp Asn Ser Gly Ser Leu 1 5 <210> 4351 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4351 gtaaaagata gagcagtgac tacggaagaa gatttccact atctcttcgg tatggacgtc 60 <210> 4352 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4352 Val Lys Asp Arg Ala Val Thr Thr Glu Glu Asp Phe His Tyr Leu Phe 1 5 10 15 Gly Met Asp Val 20 <210> 4353 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4353 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattaac tggtatttaa attggtatca acagaaacca 120 gggaaagccc ctaaactcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcagcag agtttcagta cccctctcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4354 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4354 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Trp Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4355 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4355 cagagcatta actggtat 18 <210> 4356 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4356 Gln Ser Ile Asn Trp Tyr 1 5 <210> 4357 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4357 actgcatcc 9 <210> 4358 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4358 Thr Ala Ser 1 <210> 4359 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4359 cagcagagtt tcagtacccc tctcact 27 <210> 4360 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4360 Gln Gln Ser Phe Ser Thr Pro Leu Thr 1 5 <210> 4361 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4361 gaggtgcagc tggtggagtc tgggggaggt ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gaatatgaca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtaa cataggctat 180 gcggactctg tgaagggccg attcaccatg tccagagaca acgccaagaa ctccctgtat 240 ctggaaatga acagtctgag acctgaggac acggccttgt attactgtgc aaaacataga 300 gcaataacta cggaagagat tttctactac tactatggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 4362 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4362 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys His Arg Ala Ile Thr Thr Glu Glu Ile Phe Tyr Tyr Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4363 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4363 ggattcacct ttgatgaata tgac 24 <210> 4364 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4364 Gly Phe Thr Phe Asp Glu Tyr Asp 1 5 <210> 4365 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4365 attagttgga atagtggtaa cata 24 <210> 4366 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4366 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4367 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4367 gcaaaacata gagcaataac tacggaagag attttctact actactatgg tatggacgtc 60 <210> 4368 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4368 Ala Lys His Arg Ala Ile Thr Thr Glu Glu Ile Phe Tyr Tyr Tyr Tyr 1 5 10 15 Gly Met Asp Val 20 <210> 4369 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4369 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 ttcacttgcc gggcaagtca gagcattagc agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcagcct 240 gaagattttg caacttacta ctgtcaacag agttacagta tccctcccac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4370 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4370 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4371 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4371 cagagcatta gcagttat 18 <210> 4372 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4372 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4373 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4373 gctgcatcc 9 <210> 4374 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4374 Ala Ala Ser 1 <210> 4375 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4375 caacagagtt acagtatccc tcccact 27 <210> 4376 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4376 Gln Gln Ser Tyr Ser Ile Pro Pro Thr 1 5 <210> 4377 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4377 gaggtgcagc tggtggagtc tgggggaggt gtggttcggc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttggt gattatgacc tgaactgggt ccgccaagct 120 ccagggaagg ggctggagtg ggtctctggt attaattgga atggcgatat cacaggttat 180 gcagactctg tgaagggccg attcaccata tccagagaca tagccaagaa atccctgtat 240 ctgcaaatgc acagtctgag agccgaggat tcggccttgt atttttgtgc gagggaagga 300 tgtagtagta gcagctgctt tccatattac taccagtact tcggtatgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 4378 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4378 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Asp Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Asp Ile Thr Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met His Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Phe Cys 85 90 95 Ala Arg Glu Gly Cys Ser Ser Ser Ser Cys Phe Pro Tyr Tyr Tyr Gln 100 105 110 Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 4379 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4379 ggattcacct ttggtgatta tgac 24 <210> 4380 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4380 Gly Phe Thr Phe Gly Asp Tyr Asp 1 5 <210> 4381 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4381 attaattgga atggcgatat caca 24 <210> 4382 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4382 Ile Asn Trp Asn Gly Asp Ile Thr 1 5 <210> 4383 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4383 gcgagggaag gatgtagtag tagcagctgc tttccatatt actaccagta cttcggtatg 60 gacgtc 66 <210> 4384 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4384 Ala Arg Glu Gly Cys Ser Ser Ser Ser Cys Phe Pro Tyr Tyr Tyr Gln 1 5 10 15 Tyr Phe Gly Met Asp Val 20 <210> 4385 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4385 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gaaacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacaa ctcctgatct ttttgaattc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttgggatt tattactgca tgcaggctct acaaactccg 300 tggacgttcg gccaagggac caaggtggag atcaaacga 339 <210> 4386 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4386 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Phe Leu Asn Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 4387 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4387 cagagcctcc tgcatagtaa tggaaacaac tat 33 <210> 4388 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4388 Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr 1 5 10 <210> 4389 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4389 ttgaattct 9 <210> 4390 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4390 Leu Asn Ser 1 <210> 4391 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4391 atgcaggctc tacaaactcc gtggacg 27 <210> 4392 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4392 Met Gln Ala Leu Gln Thr Pro Trp Thr 1 5 <210> 4393 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4393 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaactggat ccgacagccc 120 ccagggaagg gactggagtg gattggacat atcttttata gtgggaccac cagctacaac 180 ccctccctca agagtcgagt caccatatca gtagacacgt ccaggaatca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccgtctatt cctgtgcgag agagaggggc 300 ggttttaccg acggtgacta cggcgggttc gacccctggg gccagggaat cctggtcacc 360 gtctcctca 369 <210> 4394 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4394 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly His Ile Phe Tyr Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Ser Cys Ala 85 90 95 Arg Glu Arg Gly Gly Phe Thr Asp Gly Asp Tyr Gly Gly Phe Asp Pro 100 105 110 Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 115 120 <210> 4395 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4395 ggtggctcca tcagtactta ctac 24 <210> 4396 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4396 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 4397 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4397 atcttttata gtgggaccac c 21 <210> 4398 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4398 Ile Phe Tyr Ser Gly Thr Thr 1 5 <210> 4399 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4399 gcgagagaga ggggcggttt taccgacggt gactacggcg ggttcgaccc c 51 <210> 4400 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4400 Ala Arg Glu Arg Gly Gly Phe Thr Asp Gly Asp Tyr Gly Gly Phe Asp 1 5 10 15 Pro <210> 4401 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4401 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcgctctca ccgtcaccag tcttcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctcggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4402 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4402 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Val Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4403 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4403 cagagcatta gcacctat 18 <210> 4404 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4404 Gln Ser Ile Ser Thr Tyr 1 5 <210> 4405 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4405 gctgcatcc 9 <210> 4406 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4406 Ala Ala Ser 1 <210> 4407 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4407 caacagagtt acagtacccc tcggacg 27 <210> 4408 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4408 Gln Gln Ser Tyr Ser Thr Pro Arg Thr 1 5 <210> 4409 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4409 caggtgcagc tggtggagtc tgggggaggt ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gaatatgaca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat 180 gcggactctg tgaagggccg attcaccatg tccagagaca acgccaagaa ctccctgtat 240 ctggaaatga acagtctgag acctgaggac acggccttgt attactgtgc aaaacataga 300 gcaataacta cggaagagat tttctactac tactatggta tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 4410 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4410 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys His Arg Ala Ile Thr Thr Glu Glu Ile Phe Tyr Tyr Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4411 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4411 ggattcacct ttgatgaata tgac 24 <210> 4412 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4412 Gly Phe Thr Phe Asp Glu Tyr Asp 1 5 <210> 4413 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4413 attagttgga atagtggtag cata 24 <210> 4414 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4414 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 4415 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4415 gcaaaacata gagcaataac tacggaagag attttctact actactatgg tatggacgtc 60 <210> 4416 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4416 Ala Lys His Arg Ala Ile Thr Thr Glu Glu Ile Phe Tyr Tyr Tyr Tyr 1 5 10 15 Gly Met Asp Val 20 <210> 4417 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4417 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 ttcacttgcc gggcaagtca gagcattagc agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcagcct 240 gaagattttg caacttacta ctgtcaacag agttacagtg tccctcccac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4418 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4418 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Val Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4419 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4419 cagagcatta gcagttat 18 <210> 4420 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4420 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4421 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4421 gctgcatcc 9 <210> 4422 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4422 Ala Ala Ser 1 <210> 4423 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4423 caacagagtt acagtgtccc tcccact 27 <210> 4424 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4424 Gln Gln Ser Tyr Ser Val Pro Pro Thr 1 5 <210> 4425 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4425 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt gcttactact ggagctggat ccggcagccc 120 ccaggaaagg aactggagtg gattggttat atttattaca gtgggagaac caactacaac 180 ccctccctca ggagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatgaaagg 300 gattactatg gttcggggac ttacgactac tactactacg gtatggacgt ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 4426 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4426 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ala Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Glu Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Arg 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Glu Arg Asp Tyr Tyr Gly Ser Gly Thr Tyr Asp Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 4427 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4427 ggtggctcca tcagtgctta ctac 24 <210> 4428 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4428 Gly Gly Ser Ile Ser Ala Tyr Tyr 1 5 <210> 4429 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4429 atttattaca gtgggagaac c 21 <210> 4430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4430 Ile Tyr Tyr Ser Gly Arg Thr 1 5 <210> 4431 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4431 gcgagagatg aaagggatta ctatggttcg gggacttacg actactacta ctacggtatg 60 gacgtc 66 <210> 4432 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4432 Ala Arg Asp Glu Arg Asp Tyr Tyr Gly Ser Gly Thr Tyr Asp Tyr Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 4433 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4433 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca gggtattaac agctggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcctccagtt tgcaaagtgg ggtcccatca 180 agattcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaaaagtt tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4434 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4434 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4435 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4435 cagggtatta acagctgg 18 <210> 4436 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4436 Gln Gly Ile Asn Ser Trp 1 5 <210> 4437 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4437 gctgcctcc 9 <210> 4438 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4438 Ala Ala Ser 1 <210> 4439 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4439 caacaggcta aaagtttccc gtacact 27 <210> 4440 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4440 Gln Gln Ala Lys Ser Phe Pro Tyr Thr 1 5 <210> 4441 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4441 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt acttactact ggaactggat ccggcagccc 120 ccagggaagg gactggaatg gattgggcat atcttttata gtgggaccac caactacaac 180 ccctccctca ggagtcgagt caccatatca gtagacacgt ccaagaatca gttatccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccttttatt cctgtgcgag agagaggggc 300 ggggtaaccg acggtgacta cggcgggttc gacccctggg gccagggaac cctggtcacc 360 gtctcctca 369 <210> 4442 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4442 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly His Ile Phe Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Arg 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Phe Tyr Ser Cys Ala 85 90 95 Arg Glu Arg Gly Gly Val Thr Asp Gly Asp Tyr Gly Gly Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4443 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4443 ggtggctcca tcagtactta ctac 24 <210> 4444 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4444 Gly Gly Ser Ile Ser Thr Tyr Tyr 1 5 <210> 4445 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4445 atcttttata gtgggaccac c 21 <210> 4446 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4446 Ile Phe Tyr Ser Gly Thr Thr 1 5 <210> 4447 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4447 gcgagagaga ggggcggggt aaccgacggt gactacggcg ggttcgaccc c 51 <210> 4448 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4448 Ala Arg Glu Arg Gly Gly Val Thr Asp Gly Asp Tyr Gly Gly Phe Asp 1 5 10 15 Pro <210> 4449 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4449 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcagt 60 atcacttgcc gggcaagtca gatcattagc acctatttaa attggtatca gcagaaacca 120 ggaaaagccc ctcacctcct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctccaacct 240 gaagattttg caacttacta ctgtcaacag agttacagtg cccctcggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4450 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4450 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ile Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro His Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4451 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4451 cagatcatta gcacctat 18 <210> 4452 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4452 Gln Ile Ile Ser Thr Tyr 1 5 <210> 4453 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4453 gctgcatcc 9 <210> 4454 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4454 Ala Ala Ser 1 <210> 4455 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4455 caacagagtt acagtgcccc tcggacg 27 <210> 4456 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4456 Gln Gln Ser Tyr Ser Ala Pro Arg Thr 1 5 <210> 4457 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4457 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt gactactatt ggacctggat ccggcagtcc 120 ccagggaagg gactggagtg gattggatat atttattaca gtggcagcac caagtacaac 180 ccctccctca agagtcgagt caccatatca ctagacacgt ccaagaagca gttctccctg 240 aaactgagtt ctttgaccgc tgcggacacg gccgtgtatt actgtgtgag agataacggt 300 gacttatttg actactgggg ccagggaatc ctggtcaccg tctcctca 348 <210> 4458 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4458 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Lys Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Asp Asn Gly Asp Leu Phe Asp Tyr Trp Gly Gln Gly Ile Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 4459 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4459 ggtggctcca tcagtgacta ctat 24 <210> 4460 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4460 Gly Gly Ser Ile Ser Asp Tyr Tyr 1 5 <210> 4461 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4461 atttattaca gtggcagcac c 21 <210> 4462 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4462 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 4463 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4463 gtgagagata acggtgactt atttgactac 30 <210> 4464 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4464 Val Arg Asp Asn Gly Asp Leu Phe Asp Tyr 1 5 10 <210> 4465 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4465 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca aaccattaac acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgta gcatcccgtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 ggagattttg caacttacta ctgtcaacag agttacagtc ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4466 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4466 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Gly Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4467 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4467 caaaccatta acacctat 18 <210> 4468 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4468 Gln Thr Ile Asn Thr Tyr 1 5 <210> 4469 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4469 gtagcatcc 9 <210> 4470 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4470 Val Ala Ser 1 <210> 4471 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4471 caacagagtt acagtccccc gtacact 27 <210> 4472 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4472 Gln Gln Ser Tyr Ser Pro Pro Tyr Thr 1 5 <210> 4473 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4473 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttacttct ggagctggat ccggcagtcc 120 ccagggaagg gactggaatg gattggatac atttattata gtgggagcac caactataat 180 ccctccctcg agagtcgaat caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagttgaaat ctgtgaccgc cgcagacacg gccgtgtatt attgtgcgag agatgacgca 300 gactataacg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210> 4474 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4474 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 4475 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4475 ggtggctcca tcagtagtta cttc 24 <210> 4476 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4476 Gly Gly Ser Ile Ser Ser Tyr Phe 1 5 <210> 4477 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4477 atttattata gtgggagcac c 21 <210> 4478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4478 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 4479 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4479 gcgagagatg acgcagacta taacggtatg gacgtc 36 <210> 4480 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4480 Ala Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 4481 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4481 gacatcgtga tgacccagtc tccagtctcc ctgtccgtca cccttggaca gccggcctcc 60 atctcctgca ggtctagtca aaacctcgta tacagtgatg gaaaaaccta cttaaattgg 120 tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaacgggac 180 tctggagtcc cggacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc 240 agcagggttg aggctgagga tgttggagtt tattactgca tgcaaagtac agactggccg 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 4482 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4482 Asp Ile Val Met Thr Gln Ser Pro Val Ser Leu Ser Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Leu Val Tyr Ser 20 25 30 Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Lys Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 85 90 95 Thr Asp Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 4483 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4483 caaaacctcg tatacagtga tggaaaaacc tac 33 <210> 4484 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4484 Gln Asn Leu Val Tyr Ser Asp Gly Lys Thr Tyr 1 5 10 <210> 4485 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4485 aaggtttct 9 <210> 4486 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4486 Lys Val Ser 1 <210> 4487 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4487 atgcaaagta cagactggcc gctcact 27 <210> 4488 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4488 Met Gln Ser Thr Asp Trp Pro Leu Thr 1 5 <210> 4489 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4489 gaggtgcagc tggtggagtc gggcccagga ctggtgaaac cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcaat aattactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggaacac caaatacaac 180 ccctccctca agagtcgagt caccatatca atagacacgt ccaagaacca gttctccctg 240 aagctgagtt ctgtgaccgc tgcggacacg gccgtgtatt attgtgtgag agataacggt 300 gacttatttg actattgggg ccagggaacc ctggtcaccg tctcctca 348 <210> 4490 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4490 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Asp Asn Gly Asp Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 4491 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4491 ggtggctcca tcaataatta ctac 24 <210> 4492 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4492 Gly Gly Ser Ile Asn Asn Tyr Tyr 1 5 <210> 4493 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4493 atctattaca gtgggaacac c 21 <210> 4494 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4494 Ile Tyr Tyr Ser Gly Asn Thr 1 5 <210> 4495 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4495 gtgagagata acggtgactt atttgactat 30 <210> 4496 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4496 Val Arg Asp Asn Gly Asp Leu Phe Asp Tyr 1 5 10 <210> 4497 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4497 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc acctttttta attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4498 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4498 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Phe 20 25 30 Phe Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4499 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4499 cagagcatta gcaccttt 18 <210> 4500 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4500 Gln Ser Ile Ser Thr Phe 1 5 <210> 4501 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4501 gttgcatcc 9 <210> 4502 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4502 Val Ala Ser 1 <210> 4503 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4503 caacagagtt acagtacccc gtacact 27 <210> 4504 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4504 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 4505 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4505 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattattttt ggagttggat ccggcagtcc 120 ccagggaagg gactggaatg gattggatat atttattata gtgggagcac caattacaat 180 ccctccctcg agagtcgaat caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgaaat ctgtgaccgc cgcagacacg gccgtgtatt attgtgcgag agatgacgca 300 gactacaacg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210> 4506 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4506 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 4507 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4507 ggtggctcca tcagtaatta tttt 24 <210> 4508 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4508 Gly Gly Ser Ile Ser Asn Tyr Phe 1 5 <210> 4509 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4509 atttattata gtgggagcac c 21 <210> 4510 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4510 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 4511 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4511 gcgagagatg acgcagacta caacggtatg gacgtc 36 <210> 4512 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4512 Ala Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 4513 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4513 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc 60 atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaaaaccta cttaaattgg 120 tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaacgggac 180 tctggggtcc cggacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc 240 agcagggttg aggctgagga tgttggggtt tattactgca tgcaaagtac agactggccg 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 4514 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4514 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Lys Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 85 90 95 Thr Asp Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 4515 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4515 caaagcctcg tatacagtga tggaaaaacc tac 33 <210> 4516 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4516 Gln Ser Leu Val Tyr Ser Asp Gly Lys Thr Tyr 1 5 10 <210> 4517 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4517 aaggtttct 9 <210> 4518 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4518 Lys Val Ser 1 <210> 4519 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4519 atgcaaagta cagactggcc gctcact 27 <210> 4520 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4520 Met Gln Ser Thr Asp Trp Pro Leu Thr 1 5 <210> 4521 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4521 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attagttgga atagtggtaa tataggctat 180 gcggactctg tgaagggccg attcaccatc tcccgagaca acgccaagaa ctccctgtat 240 cttcaaatga acagtctgag agctgcggac acggccttgt atttctgtgc aaaagatata 300 gcagcagctg gcctctacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 4522 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4522 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4523 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4523 ggattcacct ttgatgattt tgcc 24 <210> 4524 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4524 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 4525 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4525 attagttgga atagtggtaa tata 24 <210> 4526 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4526 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4527 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4527 gcaaaagata tagcagcagc tggcctctac tactacggta tggacgtc 48 <210> 4528 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4528 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4529 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4529 gacatcgtga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattaac agttatttag cctggtatca gcaaaaacca 120 gggaaagccc ctaaactcct gatctatgat gcatccactt tgctaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt acccgttcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4530 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4530 Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Asn Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4531 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4531 caggacatta acagttat 18 <210> 4532 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4532 Gln Asp Ile Asn Ser Tyr 1 5 <210> 4533 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4533 gatgcatcc 9 <210> 4534 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4534 Asp Ala Ser 1 <210> 4535 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4535 caacagctta atagttaccc gttcact 27 <210> 4536 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4536 Gln Gln Leu Asn Ser Tyr Pro Phe Thr 1 5 <210> 4537 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4537 gaggtgcagc tggtggagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggatgg atcggcgctt acaaaggtga cacaaattat 180 gcacagaagc tccagggcag agtctccatg accacagaca catccacgag tacaacctac 240 atggagctga ggagccttag atctgacgac acggccgtgt atttctgtgc gagaatagca 300 gtacttggga actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 4538 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4538 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Gly Ala Tyr Lys Gly Asp Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Ile Ala Val Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 4539 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4539 ggttacacct ttaccagcta tggt 24 <210> 4540 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4540 Gly Tyr Thr Phe Thr Ser Tyr Gly 1 5 <210> 4541 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4541 atcggcgctt acaaaggtga caca 24 <210> 4542 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4542 Ile Gly Ala Tyr Lys Gly Asp Thr 1 5 <210> 4543 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4543 gcgagaatag cagtacttgg gaactttgac tac 33 <210> 4544 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4544 Ala Arg Ile Ala Val Leu Gly Asn Phe Asp Tyr 1 5 10 <210> 4545 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4545 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct tcatccagtt tacaaagtga tgtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt accctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acga 324 <210> 4546 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4546 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ser Ser Ser Leu Gln Ser Asp Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4547 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4547 cagggcatta gaaatgat 18 <210> 4548 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4548 Gln Gly Ile Arg Asn Asp 1 5 <210> 4549 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4549 gcttcatcc 9 <210> 4550 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4550 Ala Ser Ser 1 <210> 4551 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4551 ctacaagatt acaattaccc tccgacg 27 <210> 4552 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4552 Leu Gln Asp Tyr Asn Tyr Pro Pro Thr 1 5 <210> 4553 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4553 gaggtgcagc tggtggagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg cttctggtta cgcctttacc agctatggtg tcaactgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggatgg atcagcgttt acaatggtga cacagattat 180 gcacagaagt tccagggcag agtcaccatg accacagaca catccacgag tacaacctac 240 atggaactga ggagcctgag atctgacgac acggccgtgt atttctgtgc gagaatagct 300 acaactggga actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 4554 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4554 Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Gly Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Val Tyr Asn Gly Asp Thr Asp Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Ile Ala Thr Thr Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 4555 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4555 ggttacgcct ttaccagcta tggt 24 <210> 4556 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4556 Gly Tyr Ala Phe Thr Ser Tyr Gly 1 5 <210> 4557 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4557 atcagcgttt acaatggtga caca 24 <210> 4558 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4558 Ile Ser Val Tyr Asn Gly Asp Thr 1 5 <210> 4559 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4559 gcgagaatag ctacaactgg gaactttgac tac 33 <210> 4560 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4560 Ala Arg Ile Ala Thr Thr Gly Asn Phe Asp Tyr 1 5 10 <210> 4561 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4561 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct tcatccagtt tacaaaatgg tgtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt accctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4562 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4562 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ser Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4563 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4563 cagggcatta gaaatgat 18 <210> 4564 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4564 Gln Gly Ile Arg Asn Asp 1 5 <210> 4565 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4565 gcttcatcc 9 <210> 4566 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4566 Ala Ser Ser 1 <210> 4567 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4567 ctacaagatt acaattaccc tccgacg 27 <210> 4568 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4568 Leu Gln Asp Tyr Asn Tyr Pro Pro Thr 1 5 <210> 4569 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4569 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggaaggtc cctgagactc 60 tcctgtgcag cctctggaat cacctttgat gattatggct tccactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtaa cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgacgac acggccttgt attactgcgc aaaagatata 300 gcagcagctg gcctctacta ttacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 4570 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4570 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Asp Asp Tyr 20 25 30 Gly Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4571 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4571 ggaatcacct ttgatgatta tggc 24 <210> 4572 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4572 Gly Ile Thr Phe Asp Asp Tyr Gly 1 5 <210> 4573 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4573 attagttgga atagtggtaa cata 24 <210> 4574 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4574 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4575 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4575 gcaaaagata tagcagcagc tggcctctac tattacggta tggacgtc 48 <210> 4576 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4576 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4577 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4577 gacatccaga tgacccagtc accatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattact acttatttag tctggtatca gcaaaaacca 120 gggaaagccc ctaagttcct gatctatgct gcatccactt tgcaaagagg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gcagattttg caacttatta ctgtcaacag cttaatagtt atccgttcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4578 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4578 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Thr Thr Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4579 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4579 caggacatta ctacttat 18 <210> 4580 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4580 Gln Asp Ile Thr Thr Tyr 1 5 <210> 4581 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4581 gctgcatcc 9 <210> 4582 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4582 Ala Ala Ser 1 <210> 4583 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4583 caacagctta atagttatcc gttcact 27 <210> 4584 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4584 Gln Gln Leu Asn Ser Tyr Pro Phe Thr 1 5 <210> 4585 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4585 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgcactgggt ccggcaaggt 120 ccagggaagg gcctggagtg ggtctcaggc attagttgga atagtggtaa tataggctat 180 gcggactctg tgaagggccg attcaccgtc tccagagaca acgccaagag ctccctgtat 240 cttcaaatga acagtctgag agctgcggac acggccttgt atttctgtgc aaaagatata 300 gcagcagctg gcctctacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 4586 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4586 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4587 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4587 ggattcacct ttgatgattt tgcc 24 <210> 4588 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4588 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 4589 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4589 attagttgga atagtggtaa tata 24 <210> 4590 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4590 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4591 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4591 gcaaaagata tagcagcagc tggcctctac tactacggta tggacgtc 48 <210> 4592 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4592 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4593 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4593 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattaac agttatttag tctggtatca gcaaaaacca 120 gggaaagccc ctaaactcct gatctatgat gcatccactt tgctgagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagag ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt acccgttcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4594 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4594 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Asn Ser Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4595 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4595 caggacatta acagttat 18 <210> 4596 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4596 Gln Asp Ile Asn Ser Tyr 1 5 <210> 4597 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4597 gatgcatcc 9 <210> 4598 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4598 Asp Ala Ser 1 <210> 4599 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4599 caacagctta atagttaccc gttcact 27 <210> 4600 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4600 Gln Gln Leu Asn Ser Tyr Pro Phe Thr 1 5 <210> 4601 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4601 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttacttct ggagctggat ccggcagtcc 120 ccagggaagg gactggaatg gattggatat atttattata gtgggagcac caattacaat 180 ccctccctcg agagtcgaat caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgaaat ctgtgaccgc cgcagacacg gccgtgtatt attgtgcgag agatgacgca 300 gactacaacg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210> 4602 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4602 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 4603 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4603 ggtggctcca tcagtagtta cttc 24 <210> 4604 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4604 Gly Gly Ser Ile Ser Ser Tyr Phe 1 5 <210> 4605 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4605 atttattata gtgggagcac c 21 <210> 4606 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4606 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 4607 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4607 gcgagagatg acgcagacta caacggtatg gacgtc 36 <210> 4608 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4608 Ala Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 4609 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4609 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4610 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4610 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4611 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4611 cagagcatta gcagctat 18 <210> 4612 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4612 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4613 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4613 gctgcatcc 9 <210> 4614 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4614 Ala Ala Ser 1 <210> 4615 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4615 caacagagtt acagtacccc tctcact 27 <210> 4616 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4616 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 4617 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4617 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccattagt ggtttctact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac taagtacaac 180 ccctccctca agagtcgagt caccttgtca gtagacacgt ccaagaacca gttctccctg 240 aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgtgag agataacggt 300 gacttatttg actattgggg ccagggaacc acggtcaccg tctcctca 348 <210> 4618 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4618 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Phe 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Leu Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 85 90 95 Arg Asp Asn Gly Asp Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 100 105 110 Thr Val Ser Ser 115 <210> 4619 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4619 ggtggctcca ttagtggttt ctac 24 <210> 4620 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4620 Gly Gly Ser Ile Ser Gly Phe Tyr 1 5 <210> 4621 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4621 atctattaca gtgggagcac t 21 <210> 4622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4622 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 4623 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4623 gtgagagata acggtgactt atttgactat 30 <210> 4624 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4624 Val Arg Asp Asn Gly Asp Leu Phe Asp Tyr 1 5 10 <210> 4625 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4625 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa actggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgtt gcatccagtt tgcgaagtgg ggtcccatca 180 aggttcagtg gcagtgggtc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactg ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4626 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4626 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4627 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4627 cagagcatta gcagctat 18 <210> 4628 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4628 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4629 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4629 gttgcatcc 9 <210> 4630 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4630 Val Ala Ser 1 <210> 4631 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4631 caacagagtt acagtacccc gtacact 27 <210> 4632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4632 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 4633 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4633 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacgtttgat gattatgcca tgcactgggt ccggcaagtt 120 ccagggaagg gcctggagtg ggtctcaggg attagttgga atagtggtaa cataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgacaagaa ttccctgtat 240 cttcaaatga acagtctgag aactgaggac acggccttgt attactgtgc aaaagatata 300 gcagcagctg gcctctacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 4634 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4634 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4635 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4635 ggattcacgt ttgatgatta tgcc 24 <210> 4636 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4636 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 4637 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4637 attagttgga atagtggtaa cata 24 <210> 4638 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4638 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4639 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4639 gcaaaagata tagcagcagc tggcctctac tactacggta tggacgtc 48 <210> 4640 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4640 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4641 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4641 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattaac aattatttag tctggtatca gcaaaaacca 120 gggaaaggcc ctaagctcct gatctatgct gcatccactt tattaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacaa gttaacagtt acccgttcac tcttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4642 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4642 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Asn Asn Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Phe 85 90 95 Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4643 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4643 caggacatta acaattat 18 <210> 4644 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4644 Gln Asp Ile Asn Asn Tyr 1 5 <210> 4645 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4645 gctgcatcc 9 <210> 4646 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4646 Ala Ala Ser 1 <210> 4647 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4647 caacaagtta acagttaccc gttcact 27 <210> 4648 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4648 Gln Gln Val Asn Ser Tyr Pro Phe Thr 1 5 <210> 4649 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4649 caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attagttgga atagcggtaa tataggctat 180 gcggactctg tgaagggccg attcaccgtc tccagagaca acgccaagag ctccctgtat 240 cttcaaatga acagtctgag agctgcggac acggccttgt atttctgtgc aaaagatata 300 gcagcagctg gcctctacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 4650 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4650 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4651 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4651 ggattcacct ttgatgattt tgcc 24 <210> 4652 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4652 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 4653 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4653 attagttgga atagcggtaa tata 24 <210> 4654 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4654 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4655 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4655 gcaaaagata tagcagcagc tggcctctac tactacggta tggacgtc 48 <210> 4656 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4656 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4657 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4657 gacatcctga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattaac agttatttag tctggtatca gcaaaaacca 120 gggaaagccc ctaaactcct gatctatgat gcatccactt tgctgagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt acccgttcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4658 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4658 Asp Ile Leu Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Asn Ser Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4659 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4659 caggacatta acagttat 18 <210> 4660 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4660 Gln Asp Ile Asn Ser Tyr 1 5 <210> 4661 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4661 gatgcatcc 9 <210> 4662 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4662 Asp Ala Ser 1 <210> 4663 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4663 caacagctta atagttaccc gttcact 27 <210> 4664 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4664 Gln Gln Leu Asn Ser Tyr Pro Phe Thr 1 5 <210> 4665 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4665 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg gcctggagtg ggtctcaact attagtggtg gtggtggtac cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attattgtgc ggctggggat 300 cgtcttgact ggtacttcga tttttggggc cgtggcaccc tggtcaccgt ctcctca 357 <210> 4666 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4666 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Gly Asp Arg Leu Asp Trp Tyr Phe Asp Phe Trp Gly Arg Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 4667 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4667 ggattcacct ttagcagcta tgcc 24 <210> 4668 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4668 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 4669 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4669 attagtggtg gtggtggtac caca 24 <210> 4670 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4670 Ile Ser Gly Gly Gly Gly Thr Thr 1 5 <210> 4671 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4671 gcggctgggg atcgtcttga ctggtacttc gatttt 36 <210> 4672 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4672 Ala Ala Gly Asp Arg Leu Asp Trp Tyr Phe Asp Phe 1 5 10 <210> 4673 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4673 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc gggcaagtca gagcattttc acctctttaa attggtatca gcagagacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagtt ccccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 4674 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4674 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Ser Ile Phe Thr Ser 20 25 30 Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4675 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4675 cagagcattt tcacctct 18 <210> 4676 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4676 Gln Ser Ile Phe Thr Ser 1 5 <210> 4677 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4677 gctgcatcc 9 <210> 4678 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4678 Ala Ala Ser 1 <210> 4679 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4679 caacagagtt acagttcccc attcact 27 <210> 4680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4680 Gln Gln Ser Tyr Ser Ser Pro Phe Thr 1 5 <210> 4681 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4681 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attagttgga atagtggtaa tataggctat 180 gcggactctg tgaagggccg attcaccgtc tccagagaca acgccaagag ctccctgtat 240 cttcaaatga acagtctgag agctgcggac acggccttgt atttctgtgc aaaagatata 300 gcagctgctg gcctctacta ctacggtatg gacgtctggg gtcaagggac cacggtcacc 360 gtctcctca 369 <210> 4682 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4682 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4683 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4683 ggattcacct ttgatgattt tgcc 24 <210> 4684 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4684 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 4685 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4685 attagttgga atagtggtaa tata 24 <210> 4686 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4686 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4687 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4687 gcaaaagata tagcagctgc tggcctctac tactacggta tggacgtc 48 <210> 4688 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4688 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4689 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4689 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattaac agttatttag tctggtatca gcaaaaacca 120 gggaaagccc ctaaactcct gatctatgat gcatccactt tgctgagtgg ggtcccatca 180 gggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt acccgttcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4690 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4690 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Asn Ser Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Gly Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4691 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4691 caggacatta acagttat 18 <210> 4692 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4692 Gln Asp Ile Asn Ser Tyr 1 5 <210> 4693 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4693 gatgcatcc 9 <210> 4694 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4694 Asp Ala Ser 1 <210> 4695 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4695 caacagctta atagttaccc gttcact 27 <210> 4696 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4696 Gln Gln Leu Asn Ser Tyr Pro Phe Thr 1 5 <210> 4697 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4697 gaggtgcagc tggtggagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg cttctggtta cacctttagc agctatggta tcacctggat gcgacaggcc 120 cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggaga cacagactat 180 gcacagcagt tccagggcag agtcaccatg accacagaca catccacgaa cacagtctac 240 atggaactga ggagcctgag atctgacgac acggccgtgt tttactgtgc gagaatagca 300 gtacctggga actttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 4698 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4698 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 20 25 30 Gly Ile Thr Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Asp Tyr Ala Gln Gln Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Val Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Phe Tyr Cys 85 90 95 Ala Arg Ile Ala Val Pro Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 4699 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4699 ggttacacct ttagcagcta tggt 24 <210> 4700 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4700 Gly Tyr Thr Phe Ser Ser Tyr Gly 1 5 <210> 4701 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4701 atcagcgctt acaatggaga caca 24 <210> 4702 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4702 Ile Ser Ala Tyr Asn Gly Asp Thr 1 5 <210> 4703 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4703 gcgagaatag cagtacctgg gaactttgac tac 33 <210> 4704 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4704 Ala Arg Ile Ala Val Pro Gly Asn Phe Asp Tyr 1 5 10 <210> 4705 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4705 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga agtgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatggt gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattgtg caacttatta ttgtctacaa gactacaaca accctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4706 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4706 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Cys Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Asn Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4707 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4707 cagggcatta gaagtgat 18 <210> 4708 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4708 Gln Gly Ile Arg Ser Asp 1 5 <210> 4709 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4709 ggtgcatcc 9 <210> 4710 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4710 Gly Ala Ser 1 <210> 4711 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4711 ctacaagact acaacaaccc tccgacg 27 <210> 4712 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4712 Leu Gln Asp Tyr Asn Asn Pro Pro Thr 1 5 <210> 4713 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4713 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggc attagttgga atagtggtaa tataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagag gtccctgtat 240 cttcaaatga acagtctgag agctgcggac acggccttgt atttctgtgc aaaagatata 300 gcagcagctg gcctctacta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 4714 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4714 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4715 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4715 ggattcacct ttgatgattt tgcc 24 <210> 4716 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4716 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 4717 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4717 attagttgga atagtggtaa tata 24 <210> 4718 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4718 Ile Ser Trp Asn Ser Gly Asn Ile 1 5 <210> 4719 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4719 gcaaaagata tagcagcagc tggcctctac tactacggta tggacgtc 48 <210> 4720 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4720 Ala Lys Asp Ile Ala Ala Ala Gly Leu Tyr Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 4721 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4721 gacatcctga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattaac agttatttag cctggtatca gcaaaaacca 120 gggaaagccc ctaaactcct gatctatgat gcatccactt tgctaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtcaacag cttaatagtt acccgttcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4722 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4722 Asp Ile Leu Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Asn Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4723 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4723 caggacatta acagttat 18 <210> 4724 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4724 Gln Asp Ile Asn Ser Tyr 1 5 <210> 4725 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4725 gatgcatcc 9 <210> 4726 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4726 Asp Ala Ser 1 <210> 4727 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4727 caacagctta atagttaccc gttcact 27 <210> 4728 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4728 Gln Gln Leu Asn Ser Tyr Pro Phe Thr 1 5 <210> 4729 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4729 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt ggttccttct ggagctggat ccggcagtcc 120 ccagggaagg gactggaatg gattggatat atttattata ctgggagtac caattacaat 180 ccctccctcg agagtcgaat caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgaaat ctgtgaccgc cgcagacacg gccgtgtatt attgtgcgag agatgacgca 300 gactacaacg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210> 4730 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4730 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Ser 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Lys Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 4731 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4731 ggtggctcca tcagtggttc cttc 24 <210> 4732 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4732 Gly Gly Ser Ile Ser Gly Ser Phe 1 5 <210> 4733 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4733 atttattata ctgggagtac c 21 <210> 4734 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4734 Ile Tyr Tyr Thr Gly Ser Thr 1 5 <210> 4735 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4735 gcgagagatg acgcagacta caacggtatg gacgtc 36 <210> 4736 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4736 Ala Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 4737 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4737 gacatcgtga tgacccagtc tccagtctcc ctgtccgtca cccttggaca gccggcctcc 60 atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaaaaccta cttaaattgg 120 tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaacgggac 180 tctggggtcc cggacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc 240 agcagggttg aggctgagga tgttggaatt tattactgca tgcaaagtac agactggccg 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 4738 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4738 Asp Ile Val Met Thr Gln Ser Pro Val Ser Leu Ser Val Thr Leu Gly 1 5 10 15 Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 20 25 30 Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Lys Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 85 90 95 Thr Asp Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 4739 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4739 caaagcctcg tatacagtga tggaaaaacc tac 33 <210> 4740 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4740 Gln Ser Leu Val Tyr Ser Asp Gly Lys Thr Tyr 1 5 10 <210> 4741 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4741 aaggtttct 9 <210> 4742 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4742 Lys Val Ser 1 <210> 4743 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4743 atgcaaagta cagactggcc gctcact 27 <210> 4744 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4744 Met Gln Ser Thr Asp Trp Pro Leu Thr 1 5 <210> 4745 <211> 351 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4745 gaggtgcagc tggtggagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg cttcgcatta cacctttacc acctatggta tcagttgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggatgg atcagcggtt acaatggtaa cggaaacctt 180 gtaaagaagt tccaggacag agtcaccacg gccacagaca catccacgaa cacagtctac 240 atggagctga ggagcctgag atctgacgac acggccatat attactgtgc tcgaaatcgt 300 cttgattctt ttgatgtttg gggccaaggg acaatggtca ccgtctcctc a 351 <210> 4746 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4746 Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser His Tyr Thr Phe Thr Thr Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Gly Asn Gly Asn Leu Val Lys Lys Phe 50 55 60 Gln Asp Arg Val Thr Thr Ala Thr Asp Thr Ser Thr Asn Thr Val Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Asn Arg Leu Asp Ser Phe Asp Val Trp Gly Gln Gly Thr Met 100 105 110 Val Thr Val Ser Ser 115 <210> 4747 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4747 cattacacct ttaccaccta tggt 24 <210> 4748 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4748 His Tyr Thr Phe Thr Thr Tyr Gly 1 5 <210> 4749 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4749 atcagcggtt acaatggtaa cgga 24 <210> 4750 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4750 Ile Ser Gly Tyr Asn Gly Asn Gly 1 5 <210> 4751 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4751 gctcgaaatc gtcttgattc ttttgatgtt 30 <210> 4752 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4752 Ala Arg Asn Arg Leu Asp Ser Phe Asp Val 1 5 10 <210> 4753 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4753 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 ttcacttgcc gggcaagtca gagcattagc agttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcagcct 240 gaagattttg caacttacta ctgtcaacag agttacagta tccctcccac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 4754 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4754 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4755 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4755 cagagcatta gcagttat 18 <210> 4756 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4756 Gln Ser Ile Ser Ser Tyr 1 5 <210> 4757 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4757 gctgcatcc 9 <210> 4758 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4758 Ala Ala Ser 1 <210> 4759 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4759 caacagagtt acagtatccc tcccact 27 <210> 4760 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4760 Gln Gln Ser Tyr Ser Ile Pro Pro Thr 1 5 <210> 4761 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4761 caggtgcagc tggtggagtc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcaag aaacatgcta taagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttgattc aacagactac 180 gcacagaact tccagggcag agtcacgatt acctcggacg aatccacgcg cacagcctac 240 atggagatga gcagcctgag atctgaggac acggccgtat attactgtgc gagatccagt 300 ttagcaactc gtcagtggga gatattagag acggtaaact actattacta cggtatggac 360 gtctggggcc aagggaccac ggtcaccgtc tcctca 396 <210> 4762 <211> 132 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4762 Gln Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Lys His 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Asp Ser Thr Asp Tyr Ala Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ser Asp Glu Ser Thr Arg Thr Ala Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Ser Leu Ala Thr Arg Gln Trp Glu Ile Leu Glu Thr Val 100 105 110 Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 115 120 125 Thr Val Ser Ser 130 <210> 4763 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4763 ggaggcacct tcaagaaaca tgct 24 <210> 4764 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4764 Gly Gly Thr Phe Lys Lys His Ala 1 5 <210> 4765 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4765 atcatcccta tctttgattc aaca 24 <210> 4766 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4766 Ile Ile Pro Ile Phe Asp Ser Thr 1 5 <210> 4767 <211> 75 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4767 gcgagatcca gtttagcaac tcgtcagtgg gagatattag agacggtaaa ctactattac 60 tacggtatgg acgtc 75 <210> 4768 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4768 Ala Arg Ser Ser Leu Ala Thr Arg Gln Trp Glu Ile Leu Glu Thr Val 1 5 10 15 Asn Tyr Tyr Tyr Tyr Gly Met Asp Val 20 25 <210> 4769 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4769 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tattcacttt cggccctggg 300 accaaggtgg agatcaaacg a 321 <210> 4770 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4770 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Phe Thr 85 90 95 Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4771 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4771 caggacatta gcaactat 18 <210> 4772 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4772 Gln Asp Ile Ser Asn Tyr 1 5 <210> 4773 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4773 gatgcatcc 9 <210> 4774 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4774 Asp Ala Ser 1 <210> 4775 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4775 caacagtatg ataatctatt cact 24 <210> 4776 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4776 Gln Gln Tyr Asp Asn Leu Phe Thr 1 5 <210> 4777 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4777 gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc aggtatgcta tcagctggat gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tatttagtac agcagactac 180 gaacagaagt ttaagggcag agtcacgatt accacggacg aatccacggg cacagcctac 240 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagccagt 300 ctagcagctc gtcagtggga gataagagag agggtaagcc actactactt cggtatggac 360 gtctggggcc aagggaccac ggtcaccgtc tcctca 396 <210> 4778 <211> 132 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4778 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 20 25 30 Ala Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Ser Thr Ala Asp Tyr Glu Gln Lys Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Gly Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ser Leu Ala Ala Arg Gln Trp Glu Ile Arg Glu Arg Val 100 105 110 Ser His Tyr Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 115 120 125 Thr Val Ser Ser 130 <210> 4779 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4779 ggaggcacct tcagcaggta tgct 24 <210> 4780 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4780 Gly Gly Thr Phe Ser Arg Tyr Ala 1 5 <210> 4781 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4781 atcatcccta tatttagtac agca 24 <210> 4782 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4782 Ile Ile Pro Ile Phe Ser Thr Ala 1 5 <210> 4783 <211> 75 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4783 gcgagagcca gtctagcagc tcgtcagtgg gagataagag agagggtaag ccactactac 60 ttcggtatgg acgtc 75 <210> 4784 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4784 Ala Arg Ala Ser Leu Ala Ala Arg Gln Trp Glu Ile Arg Glu Arg Val 1 5 10 15 Ser His Tyr Tyr Phe Gly Met Asp Val 20 25 <210> 4785 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4785 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt aactggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag gctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4786 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4786 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4787 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4787 cagagtatta gtaactgg 18 <210> 4788 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4788 Gln Ser Ile Ser Asn Trp 1 5 <210> 4789 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4789 aaggcgtct 9 <210> 4790 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4790 Lys Ala Ser 1 <210> 4791 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4791 caacagtata atagttattc tccgacg 27 <210> 4792 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4792 Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 4793 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4793 gaggtgcagc tggtggagtc tggggcagag gtgaagaggc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagg aagtatgctg tcagctgggt gcgacaggcc 120 cccggacaag ggcttgagtg gatgggaggg atcatcccta tatttagtac agcagactac 180 gaagagaaat ttaagggcag agtcacgatc accacggacg aatccacggg cacagcctac 240 atggagctga ctagcctgag atctgaggac acggccgtgt attactgtgc gagagccagt 300 ctagcagttc gtcagtggga gataagagag acgataagcc actactactt cggtatggac 360 gtctggggcc aagggaccac ggtcaccgtc tcctca 396 <210> 4794 <211> 132 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4794 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Lys Tyr 20 25 30 Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Ser Thr Ala Asp Tyr Glu Glu Lys Phe 50 55 60 Lys Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Gly Thr Ala Tyr 65 70 75 80 Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ser Leu Ala Val Arg Gln Trp Glu Ile Arg Glu Thr Ile 100 105 110 Ser His Tyr Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 115 120 125 Thr Val Ser Ser 130 <210> 4795 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4795 ggaggcacct tcaggaagta tgct 24 <210> 4796 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4796 Gly Gly Thr Phe Arg Lys Tyr Ala 1 5 <210> 4797 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4797 atcatcccta tatttagtac agca 24 <210> 4798 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4798 Ile Ile Pro Ile Phe Ser Thr Ala 1 5 <210> 4799 <211> 75 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4799 gcgagagcca gtctagcagt tcgtcagtgg gagataagag agacgataag ccactactac 60 ttcggtatgg acgtc 75 <210> 4800 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4800 Ala Arg Ala Ser Leu Ala Val Arg Gln Trp Glu Ile Arg Glu Thr Ile 1 5 10 15 Ser His Tyr Tyr Phe Gly Met Asp Val 20 25 <210> 4801 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4801 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaatta 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaatagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4802 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4802 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Ile Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4803 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4803 caggacatta gcaactat 18 <210> 4804 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4804 Gln Asp Ile Ser Asn Tyr 1 5 <210> 4805 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4805 gatgcatcc 9 <210> 4806 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4806 Asp Ala Ser 1 <210> 4807 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4807 caacagtatg ataatctccc gctcact 27 <210> 4808 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4808 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 4809 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4809 gaggtgcagc tggtggagtc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcaac aagcatgcta taagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcagactac 180 gcacagaagt tccagggcag aatcacgatt accacggacg aatccacgcg cacagcctac 240 atggaactgc gcagcctgag atctgaggac acggccgtat attactgtgc gagatccagt 300 ttagcaactc gtcagtggga gatattagag acgataacct actactacta cggtatggac 360 gtctggggcc aagggaccac ggtcaccgtc tcctca 396 <210> 4810 <211> 132 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4810 Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Lys His 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Ile Thr Ile Thr Thr Asp Glu Ser Thr Arg Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Ser Leu Ala Thr Arg Gln Trp Glu Ile Leu Glu Thr Ile 100 105 110 Thr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 115 120 125 Thr Val Ser Ser 130 <210> 4811 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4811 ggaggcacct tcaacaagca tgct 24 <210> 4812 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4812 Gly Gly Thr Phe Asn Lys His Ala 1 5 <210> 4813 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4813 atcatcccta tctttggtac agca 24 <210> 4814 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4814 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 4815 <211> 75 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4815 gcgagatcca gtttagcaac tcgtcagtgg gagatattag agacgataac ctactactac 60 tacggtatgg acgtc 75 <210> 4816 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4816 Ala Arg Ser Ser Leu Ala Thr Arg Gln Trp Glu Ile Leu Glu Thr Ile 1 5 10 15 Thr Tyr Tyr Tyr Tyr Gly Met Asp Val 20 25 <210> 4817 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4817 gacatcgtga tgacccagtc tccctccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg agtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4818 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4818 Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4819 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4819 cagagtatta gtagctgg 18 <210> 4820 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4820 Gln Ser Ile Ser Ser Trp 1 5 <210> 4821 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4821 aaggcgtct 9 <210> 4822 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4822 Lys Ala Ser 1 <210> 4823 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4823 caacactata atagttattc tccgacg 27 <210> 4824 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4824 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 4825 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4825 caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtt 60 tcctgtaagg cttctggagg caccttcaga agatatgcta tcagttgggt gcgacaggcc 120 cctggacaag ggctagagtg gatgggaggg atcatcccta tctttgatac agcaaactac 180 gcacagaaat tccagggcag agtcacgatt accacggacg aatccacgag cacagcctac 240 atggagctga gcagcctgag atctgaggac tcggccgtgt attactgtgc gagatccagt 300 atgacaattc gtcagtggga aatactggag aacataaact actactatta tggtatggac 360 gtctggggcc aagggtccac ggtcaccgtc tcctca 396 <210> 4826 <211> 132 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4826 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Arg Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Ser Met Thr Ile Arg Gln Trp Glu Ile Leu Glu Asn Ile 100 105 110 Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Ser Thr Val 115 120 125 Thr Val Ser Ser 130 <210> 4827 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4827 ggaggcacct tcagaagata tgct 24 <210> 4828 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4828 Gly Gly Thr Phe Arg Arg Tyr Ala 1 5 <210> 4829 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4829 atcatcccta tctttgatac agca 24 <210> 4830 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4830 Ile Ile Pro Ile Phe Asp Thr Ala 1 5 <210> 4831 <211> 75 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4831 gcgagatcca gtatgacaat tcgtcagtgg gaaatactgg agaacataaa ctactactat 60 tatggtatgg acgtc 75 <210> 4832 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4832 Ala Arg Ser Ser Met Thr Ile Arg Gln Trp Glu Ile Leu Glu Asn Ile 1 5 10 15 Asn Tyr Tyr Tyr Tyr Gly Met Asp Val 20 25 <210> 4833 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4833 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatgag gcgtctagtt tagacagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctacagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4834 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4834 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4835 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4835 cagagtatta gtagctgg 18 <210> 4836 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4836 Gln Ser Ile Ser Ser Trp 1 5 <210> 4837 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4837 gaggcgtct 9 <210> 4838 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4838 Glu Ala Ser 1 <210> 4839 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4839 caacactata atagttattc tccgacg 27 <210> 4840 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4840 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 4841 <211> 396 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4841 gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcaga agatatgctg tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg ggtgggaggg atcatcccta tctttggtac agcaagctac 180 gcacagaagt tccagggcag agtcacgatt agcacggacg aatccacgag cacagcctac 240 atggagctga gcagcctgag atctgaggac tcggccgtgt attactgtgc gagagccagt 300 ataacaactc gtcagtggga gatactggag aacataaact actactacta cggtatggac 360 gtctggggcc aagggtccac ggtcaccgtc tcctca 396 <210> 4842 <211> 132 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4842 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Arg Tyr 20 25 30 Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Ser Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ser Ile Thr Thr Arg Gln Trp Glu Ile Leu Glu Asn Ile 100 105 110 Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Ser Thr Val 115 120 125 Thr Val Ser Ser 130 <210> 4843 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4843 ggaggcacct tcagaagata tgct 24 <210> 4844 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4844 Gly Gly Thr Phe Arg Arg Tyr Ala 1 5 <210> 4845 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4845 atcatcccta tctttggtac agca 24 <210> 4846 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4846 Ile Ile Pro Ile Phe Gly Thr Ala 1 5 <210> 4847 <211> 75 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4847 gcgagagcca gtataacaac tcgtcagtgg gagatactgg agaacataaa ctactactac 60 tacggtatgg acgtc 75 <210> 4848 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4848 Ala Arg Ala Ser Ile Thr Thr Arg Gln Trp Glu Ile Leu Glu Asn Ile 1 5 10 15 Asn Tyr Tyr Tyr Tyr Gly Met Asp Val 20 25 <210> 4849 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4849 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4850 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4850 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4851 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4851 caggacatta gcaactat 18 <210> 4852 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4852 Gln Asp Ile Ser Asn Tyr 1 5 <210> 4853 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4853 gatgcatcc 9 <210> 4854 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4854 Asp Ala Ser 1 <210> 4855 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4855 caacagtatg ataatctccc gctcact 27 <210> 4856 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4856 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 4857 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4857 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcggt aattactact ggagctggat ccggcagccc 120 ccaggaaagg gactggagtg gattggatat atctattaca gtgagaacac caactacaac 180 ccctccctca agagtcgagt caccatatct gtggccacgt ccaagaacca gttctccctg 240 aagttggatt ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgcg acatagagaa 300 gatattttga ctggttatta tagcggctat tttgactact ggggccaggg aaccctggtc 360 accgtctcct ca 372 <210> 4858 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4858 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Gly Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Glu Asn Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Ala Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asp Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg His Arg Glu Asp Ile Leu Thr Gly Tyr Tyr Ser Gly Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4859 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4859 ggtggctcca tcggtaatta ctac 24 <210> 4860 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4860 Gly Gly Ser Ile Gly Asn Tyr Tyr 1 5 <210> 4861 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4861 atctattaca gtgagaacac c 21 <210> 4862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4862 Ile Tyr Tyr Ser Glu Asn Thr 1 5 <210> 4863 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4863 gcgcgacata gagaagatat tttgactggt tattatagcg gctattttga ctac 54 <210> 4864 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4864 Ala Arg His Arg Glu Asp Ile Leu Thr Gly Tyr Tyr Ser Gly Tyr Phe 1 5 10 15 Asp Tyr <210> 4865 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4865 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gagtgttttc tacagctcca acaataagaa ctacttagct 120 tggtaccagc agaaaccagg acagcctcct aagctgctca tttactggtc atctacccgg 180 gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatatggca gtttattact gtcaccaata ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 4866 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4866 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Phe Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ser Ser Thr Arg Glu Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Met Ala Val Tyr Tyr Cys His Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 4867 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4867 cagagtgttt tctacagctc caacaataag aactac 36 <210> 4868 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4868 Gln Ser Val Phe Tyr Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 4869 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4869 tggtcatct 9 <210> 4870 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4870 Trp Ser Ser 1 <210> 4871 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4871 caccaatatt ataatactcc gtggacg 27 <210> 4872 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4872 His Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 4873 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4873 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccggcagccc 120 ccagggaggg gcctggagtg gattggatat atctatgaca gtgggagcac taactacaac 180 ccctccctca agagtcgagt catcatatca gtagacacgt ccaagaacca gttctccctg 240 aagttgagct ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag acatagagac 300 gatattttga ctggttatta taccggctat tttgactact ggggccaggg aaccacggtc 360 accgtctcct ca 372 <210> 4874 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4874 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Asp Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg His Arg Asp Asp Ile Leu Thr Gly Tyr Tyr Thr Gly Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 4875 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4875 ggtggctcca tcagtaatta ctac 24 <210> 4876 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4876 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 4877 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4877 atctatgaca gtgggagcac t 21 <210> 4878 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4878 Ile Tyr Asp Ser Gly Ser Thr 1 5 <210> 4879 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4879 gcgagacata gagacgatat tttgactggt tattataccg gctattttga ctac 54 <210> 4880 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4880 Ala Arg His Arg Asp Asp Ile Leu Thr Gly Tyr Tyr Thr Gly Tyr Phe 1 5 10 15 Asp Tyr <210> 4881 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4881 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gaatgtttta ttcaactcca acaataagaa gtacttagcc 120 tggtaccaga agaaaccagg acagcctcca aagttactca tttactgggc atctacccgg 180 gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 4882 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4882 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Val Leu Phe Asn 20 25 30 Ser Asn Asn Lys Lys Tyr Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 4883 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4883 cagaatgttt tattcaactc caacaataag aagtac 36 <210> 4884 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4884 Gln Asn Val Leu Phe Asn Ser Asn Asn Lys Lys Tyr 1 5 10 <210> 4885 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4885 tgggcatct 9 <210> 4886 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4886 Trp Ala Ser 1 <210> 4887 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4887 cagcaatatt ataatactcc gtggacg 27 <210> 4888 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4888 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 4889 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4889 caggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcgctg tctctggtgg ctccatcagt atttactact ggagctggat ccggcagtcc 120 ccagggaagg gactggagtg gattgggtat atgtataaca gtgggagcac caactacaat 180 ccctccctca agagtcgagt ctccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgacct ctgtgaccgc cacagacacg gccgtgtatt tctgtgcgag acatagaaac 300 gatattttga ctggttatta tagcggctac ttagactact ggggccaggg aaccctggtc 360 accgtctcct ca 372 <210> 4890 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4890 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ile Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Met Tyr Asn Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Thr Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg His Arg Asn Asp Ile Leu Thr Gly Tyr Tyr Ser Gly Tyr Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 4891 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4891 ggtggctcca tcagtattta ctac 24 <210> 4892 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4892 Gly Gly Ser Ile Ser Ile Tyr Tyr 1 5 <210> 4893 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4893 atgtataaca gtgggagcac c 21 <210> 4894 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4894 Met Tyr Asn Ser Gly Ser Thr 1 5 <210> 4895 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4895 gcgagacata gaaacgatat tttgactggt tattatagcg gctacttaga ctac 54 <210> 4896 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4896 Ala Arg His Arg Asn Asp Ile Leu Thr Gly Tyr Tyr Ser Gly Tyr Leu 1 5 10 15 Asp Tyr <210> 4897 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4897 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gaatgtttta ttcaactcca acaataagaa atacttagcc 120 tggtaccagc agaaaccagg acagcctcct aagttactcg tttactgggc atctacccgg 180 gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 4898 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4898 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Val Leu Phe Asn 20 25 30 Ser Asn Asn Lys Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Val Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 4899 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4899 cagaatgttt tattcaactc caacaataag aaatac 36 <210> 4900 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4900 Gln Asn Val Leu Phe Asn Ser Asn Asn Lys Lys Tyr 1 5 10 <210> 4901 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4901 tgggcatct 9 <210> 4902 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4902 Trp Ala Ser 1 <210> 4903 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4903 cagcaatatt ataatactcc gtggacg 27 <210> 4904 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4904 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 4905 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4905 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac acggccttgt attactgtgc aaaagatggg 300 gcagtagtag cagctgctac ttcctactgg tacttcgatc tgtggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 4906 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4906 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 4907 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4907 ggattcacct ttgatgatta tgcc 24 <210> 4908 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4908 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 4909 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4909 attagttgga atagtggtag cata 24 <210> 4910 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4910 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 4911 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4911 gcaaaagatg gggcagtagt agcagctgct acttcctact ggtacttcga tctg 54 <210> 4912 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4912 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 4913 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4913 gacatcgtga tgacccagtc tccttccacc ctgtctacat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcggaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4914 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4914 Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4915 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4915 cagagtatta gtagctgg 18 <210> 4916 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4916 Gln Ser Ile Ser Ser Trp 1 5 <210> 4917 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4917 aaggcgtct 9 <210> 4918 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4918 Lys Ala Ser 1 <210> 4919 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4919 caacactata atagttattc tccgacg 27 <210> 4920 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4920 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 4921 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4921 gaggtgcagc tggtggagtc tgggggaggc ttggtacagt cgggggggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttagc aactatgcca tgacctgggt ctgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtgatag gacatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaactaggg 300 tatagcatct cgtccccttt tgactactgg ggccagggaa ccatggtcac cgtctcctca 360 <210> 4922 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4922 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Ala Met Thr Trp Val Cys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Tyr Ser Ile Ser Ser Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 4923 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4923 ggattcacct ttagcaacta tgcc 24 <210> 4924 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4924 Gly Phe Thr Phe Ser Asn Tyr Ala 1 5 <210> 4925 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4925 attagtggta gtggtgatag gaca 24 <210> 4926 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4926 Ile Ser Gly Ser Gly Asp Arg Thr 1 5 <210> 4927 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4927 gcgaaactag ggtatagcat ctcgtcccct tttgactac 39 <210> 4928 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4928 Ala Lys Leu Gly Tyr Ser Ile Ser Ser Pro Phe Asp Tyr 1 5 10 <210> 4929 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4929 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcatgagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaacctcct gatctacact gcctccagtt tacaaactgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagactttg caacttactt ctgtcaacag agttacggta cccctcccac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4930 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4930 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Gly Thr Pro Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4931 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4931 cagagcatga gcagctat 18 <210> 4932 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4932 Gln Ser Met Ser Ser Tyr 1 5 <210> 4933 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4933 actgcctcc 9 <210> 4934 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4934 Thr Ala Ser 1 <210> 4935 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4935 caacagagtt acggtacccc tcccact 27 <210> 4936 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4936 Gln Gln Ser Tyr Gly Thr Pro Pro Thr 1 5 <210> 4937 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4937 caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccggcaaggt 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatt tccagagaca acgccaagaa gttcctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gtagtagtag cagctgcaac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 4938 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4938 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Phe Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 4939 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4939 ggattcacct ttgatgatta tgcc 24 <210> 4940 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4940 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 4941 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4941 attagttgga atagtggtag cata 24 <210> 4942 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4942 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 4943 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4943 gcaaaagatg gggtagtagt agcagctgca acttcctact ggtacttcga tctc 54 <210> 4944 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4944 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 4945 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4945 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4946 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4946 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4947 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4947 cagagtatta gtagctgg 18 <210> 4948 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4948 Gln Ser Ile Ser Ser Trp 1 5 <210> 4949 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4949 aaggcgtct 9 <210> 4950 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4950 Lys Ala Ser 1 <210> 4951 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4951 caacagtata atagttattc tccgacg 27 <210> 4952 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4952 Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 4953 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4953 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcaat gattactact ggagctggat ccgccagtcc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcat caactacaac 180 ccgtccctca agagtcgagt caccatatca gtggacacgt ccaagaacca cttctccctg 240 aacctgacct ctgtgaccgc cgcggacacg gctgtatatt actgtgcgag ggtcaatggg 300 aactccttgg accactgggg ccagggagcc ctggtcaccg tctcctca 348 <210> 4954 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4954 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Asp Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Ile Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Val Asn Gly Asn Ser Leu Asp His Trp Gly Gln Gly Ala Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 4955 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4955 ggtgggtcct tcaatgatta ctac 24 <210> 4956 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4956 Gly Gly Ser Phe Asn Asp Tyr Tyr 1 5 <210> 4957 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4957 atcaatcata gtggaagcat c 21 <210> 4958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4958 Ile Asn His Ser Gly Ser Ile 1 5 <210> 4959 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4959 gcgagggtca atgggaactc cttggaccac 30 <210> 4960 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4960 Ala Arg Val Asn Gly Asn Ser Leu Asp His 1 5 10 <210> 4961 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4961 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggtcattaga actgatttag gctggtatca gcagaagcca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tagaaagagg ggtctcatca 180 agattcagcg gcagtagatc tggcacagtt ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctgcaa gattacaatt acccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 4962 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4962 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Ile Arg Thr Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Glu Arg Gly Val Ser Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4963 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4963 caggtcatta gaactgat 18 <210> 4964 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4964 Gln Val Ile Arg Thr Asp 1 5 <210> 4965 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4965 gctgcatcc 9 <210> 4966 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4966 Ala Ala Ser 1 <210> 4967 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4967 ctgcaagatt acaattaccc gctcact 27 <210> 4968 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4968 Leu Gln Asp Tyr Asn Tyr Pro Leu Thr 1 5 <210> 4969 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4969 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggttat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac acggccttgt attactgtgc aaaagatggg 300 gtagtagtag cagatgctaa ttcctactgg tatttcgatc tctggggccg tggcaccatg 360 gtcaccgtct cctca 375 <210> 4970 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4970 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Val Val Val Ala Asp Ala Asn Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 4971 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4971 ggattcacct ttgatgatta tgcc 24 <210> 4972 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4972 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 4973 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4973 attagttgga atagtggtag cata 24 <210> 4974 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4974 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 4975 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4975 gcaaaagatg gggtagtagt agcagatgct aattcctact ggtatttcga tctc 54 <210> 4976 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4976 Ala Lys Asp Gly Val Val Val Ala Asp Ala Asn Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 4977 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4977 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt aactggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag gctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4978 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4978 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4979 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4979 cagagtatta gtaactgg 18 <210> 4980 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4980 Gln Ser Ile Ser Asn Trp 1 5 <210> 4981 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4981 aaggcgtct 9 <210> 4982 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4982 Lys Ala Ser 1 <210> 4983 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4983 caacagtata atagttattc tccgacg 27 <210> 4984 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4984 Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 4985 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4985 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attacttgga atagtggtgg catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctatat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gcagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 4986 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4986 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Trp Asn Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 4987 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4987 ggattcacct ttgatgattt tgcc 24 <210> 4988 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4988 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 4989 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4989 attacttgga atagtggtgg cata 24 <210> 4990 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4990 Ile Thr Trp Asn Ser Gly Gly Ile 1 5 <210> 4991 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4991 gcaaaagatg gggcagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 4992 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4992 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 4993 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4993 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattggt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagttcct gatctatgag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 4994 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4994 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 35 40 45 Tyr Glu Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 4995 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4995 cagagtattg gtagctgg 18 <210> 4996 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4996 Gln Ser Ile Gly Ser Trp 1 5 <210> 4997 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4997 gaggcgtct 9 <210> 4998 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 4998 Glu Ala Ser 1 <210> 4999 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 4999 caacagtata atagttattc tccgacg 27 <210> 5000 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5000 Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5001 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5001 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gtagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 5002 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5002 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 5003 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5003 ggattcacct ttgatgatta tgcc 24 <210> 5004 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5004 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5005 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5005 attagttgga atagtggtag cata 24 <210> 5006 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5006 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 5007 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5007 gcaaaagatg gggtagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 5008 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5008 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5009 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5009 gacatccaga tgacccagtc tccctccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg agtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5010 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5010 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5011 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5011 cagagtatta gtagctgg 18 <210> 5012 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5012 Gln Ser Ile Ser Ser Trp 1 5 <210> 5013 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5013 aaggcgtct 9 <210> 5014 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5014 Lys Ala Ser 1 <210> 5015 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5015 caacactata atagttattc tccgacg 27 <210> 5016 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5016 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5017 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5017 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccgggagccc 120 ccagggaagg gactggagtg gattggatat atctataaca gtgggagcac caactacaac 180 ccctccctca agagtcgagt catcatatca ggagacacgt ccaagaacca gttctccctg 240 aagttgagct ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag acatagagac 300 gatattctga ctggttatta tagcggctat tttgaccact ggggccaggg gaccctggtc 360 accgtctcct ca 372 <210> 5018 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5018 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Glu Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Asn Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ile Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg His Arg Asp Asp Ile Leu Thr Gly Tyr Tyr Ser Gly Tyr Phe Asp 100 105 110 His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5019 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5019 ggtggctcca tcagtaatta ctac 24 <210> 5020 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5020 Gly Gly Ser Ile Ser Asn Tyr Tyr 1 5 <210> 5021 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5021 atctataaca gtgggagcac c 21 <210> 5022 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5022 Ile Tyr Asn Ser Gly Ser Thr 1 5 <210> 5023 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5023 gcgagacata gagacgatat tctgactggt tattatagcg gctattttga ccac 54 <210> 5024 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5024 Ala Arg His Arg Asp Asp Ile Leu Thr Gly Tyr Tyr Ser Gly Tyr Phe 1 5 10 15 Asp His <210> 5025 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5025 gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccaagta caatatttta tacagctcca acaataagaa ctacttagct 120 tggtaccagc agaaaccggg acagtctcct aaactgctca tttactgggc atctacccgg 180 gaattcgggg tccctgaccg attcagcggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcaacaatc ttataatact 300 ccgtacactt ttggccaggg gaccaaggtg gagatcaaac ga 342 <210> 5026 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5026 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Lys Tyr Asn Ile Leu Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Phe Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Ser Tyr Asn Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 5027 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5027 tacaatattt tatacagctc caacaataag aactac 36 <210> 5028 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5028 Tyr Asn Ile Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 5029 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5029 tgggcatct 9 <210> 5030 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5030 Trp Ala Ser 1 <210> 5031 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5031 caacaatctt ataatactcc gtacact 27 <210> 5032 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5032 Gln Gln Ser Tyr Asn Thr Pro Tyr Thr 1 5 <210> 5033 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5033 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac acggcctggt attactgtgc aaaagatggg 300 gcagtagtag ccgctgctac ttcccactgg tacttcgatc tgtggggccg tggcaccatg 360 gtcaccgtct cctca 375 <210> 5034 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5034 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Trp Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser His Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 5035 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5035 ggattcacct ttgatgatta tgcc 24 <210> 5036 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5036 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5037 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5037 attagttgga atagtggtag cata 24 <210> 5038 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5038 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 5039 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5039 gcaaaagatg gggcagtagt agccgctgct acttcccact ggtacttcga tctg 54 <210> 5040 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5040 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser His Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5041 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5041 gacatccaga tgacccagtc tccttccacc ctgtctacat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcggaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5042 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5042 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5043 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5043 cagagtatta gtagctgg 18 <210> 5044 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5044 Gln Ser Ile Ser Ser Trp 1 5 <210> 5045 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5045 aaggcgtct 9 <210> 5046 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5046 Lys Ala Ser 1 <210> 5047 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5047 caacactata atagttattc tccgacg 27 <210> 5048 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5048 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5049 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5049 gaggtgcagc tggtggagtc tggaggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agttatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat 180 gcagagtccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaagac acggctgtgt attactgtgc gagagagtct 300 ctctctacgc acggtcccct ttactactac tactacggca tggacgtctg gggccaaggg 360 accacggtca ccgtctcctc a 381 <210> 5050 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5050 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ser Leu Ser Thr His Gly Pro Leu Tyr Tyr Tyr Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5051 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5051 ggattcacct tcagtagtta tggc 24 <210> 5052 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5052 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 5053 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5053 atatggtatg atggaagtaa taaa 24 <210> 5054 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5054 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 5055 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5055 gcgagagagt ctctctctac gcacggtccc ctttactact actactacgg catggacgtc 60 <210> 5056 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5056 Ala Arg Glu Ser Leu Ser Thr His Gly Pro Leu Tyr Tyr Tyr Tyr Tyr 1 5 10 15 Gly Met Asp Val 20 <210> 5057 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5057 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagactcacc 60 atcacttgcc gggcaagtca gaccattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgct gcatccagtt tggaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ttgtcaagag agttacaata cccctctcac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5058 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5058 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Leu Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Glu Ser Tyr Asn Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5059 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5059 cagaccatta gcagctat 18 <210> 5060 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5060 Gln Thr Ile Ser Ser Tyr 1 5 <210> 5061 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5061 gctgcatcc 9 <210> 5062 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5062 Ala Ala Ser 1 <210> 5063 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5063 caagagagtt acaatacccc tctcact 27 <210> 5064 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5064 Gln Glu Ser Tyr Asn Thr Pro Leu Thr 1 5 <210> 5065 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5065 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcgctg tctctggtgg ctccatcagt atttactact ggagctggat ccggcagtcc 120 ccagggaagg gactggagtg gattgggtat atgtataaca gtgggaccac caagtacaat 180 ccctccctca agagtcgagt ctccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgacct ctgtgaccgc cacagacacg gccgtgtatt tctgtgcgcg acatagaaac 300 gatcttttga ctggttatta tagcggctac ttagactact ggggccaggg aaccatggtc 360 accgtctcct ca 372 <210> 5066 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5066 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ile Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Met Tyr Asn Ser Gly Thr Thr Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Thr Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg His Arg Asn Asp Leu Leu Thr Gly Tyr Tyr Ser Gly Tyr Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5067 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5067 ggtggctcca tcagtattta ctac 24 <210> 5068 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5068 Gly Gly Ser Ile Ser Ile Tyr Tyr 1 5 <210> 5069 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5069 atgtataaca gtgggaccac c 21 <210> 5070 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5070 Met Tyr Asn Ser Gly Thr Thr 1 5 <210> 5071 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5071 gcgcgacata gaaacgatct tttgactggt tattatagcg gctacttaga ctac 54 <210> 5072 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5072 Ala Arg His Arg Asn Asp Leu Leu Thr Gly Tyr Tyr Ser Gly Tyr Leu 1 5 10 15 Asp Tyr <210> 5073 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5073 gacatcctga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcgactgca agtccagcca cagtgtttta tacagctcca acaataagaa ttacttagct 120 tggtaccagc agaaaccagg acagcctcct aaactgctca tttactgggc atctatccgg 180 gattccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcagtctga agatgtggca gtttatttct gtcagcagtc ttataatgct 300 ccgtacactt ttggccaggg gaccaaggtg gagatcaaac ga 342 <210> 5074 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5074 Asp Ile Leu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asp Cys Lys Ser Ser His Ser Val Leu Tyr Ser 20 25 30 Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Asp Ser Gly Val 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ser Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 85 90 95 Ser Tyr Asn Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 5075 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5075 cacagtgttt tatacagctc caacaataag aattac 36 <210> 5076 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5076 His Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 1 5 10 <210> 5077 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5077 tgggcatct 9 <210> 5078 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5078 Trp Ala Ser 1 <210> 5079 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5079 cagcagtctt ataatgctcc gtacact 27 <210> 5080 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5080 Gln Gln Ser Tyr Asn Ala Pro Tyr Thr 1 5 <210> 5081 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5081 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attacttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctggaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gtagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 5082 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5082 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 5083 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5083 ggattcacct ttgatgatta tgcc 24 <210> 5084 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5084 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5085 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5085 attacttgga atagtggtag cata 24 <210> 5086 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5086 Ile Thr Trp Asn Ser Gly Ser Ile 1 5 <210> 5087 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5087 gcaaaagatg gggtagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 5088 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5088 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5089 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5089 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatgag gcgtctagtt tagacagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctacagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5090 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5090 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5091 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5091 cagagtatta gtagctgg 18 <210> 5092 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5092 Gln Ser Ile Ser Ser Trp 1 5 <210> 5093 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5093 gaggcgtct 9 <210> 5094 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5094 Glu Ala Ser 1 <210> 5095 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5095 caacactata atagttattc tccgacg 27 <210> 5096 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5096 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5097 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5097 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attacttgga atagtggtag tatagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctatat 240 ctgcaaatga acagtctgag aactgaggac acggccttgt attactgtgc aaaagatggg 300 gcagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccatg 360 gtcaccgtct cctca 375 <210> 5098 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5098 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 5099 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5099 ggattcacct ttgatgattt tgcc 24 <210> 5100 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5100 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 5101 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5101 attacttgga atagtggtag tata 24 <210> 5102 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5102 Ile Thr Trp Asn Ser Gly Ser Ile 1 5 <210> 5103 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5103 gcaaaagatg gggcagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 5104 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5104 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5105 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5105 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5106 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5106 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5107 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5107 caggacatta gcaactat 18 <210> 5108 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5108 Gln Asp Ile Ser Asn Tyr 1 5 <210> 5109 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5109 gatgcatcc 9 <210> 5110 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5110 Asp Ala Ser 1 <210> 5111 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5111 caacagtatg ataatctccc gctcact 27 <210> 5112 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5112 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 5113 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5113 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gactttgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt atcacttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctatat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gcagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 5114 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5114 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 5115 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5115 ggattcacct ttgatgactt tgcc 24 <210> 5116 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5116 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 5117 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5117 atcacttgga atagtggtag cata 24 <210> 5118 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5118 Ile Thr Trp Asn Ser Gly Ser Ile 1 5 <210> 5119 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5119 gcaaaagatg gggcagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 5120 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5120 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5121 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5121 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaaggtcct gatctataag gcgtctagtt tagaaggtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctct ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5122 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5122 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5123 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5123 cagagtatta gtagctgg 18 <210> 5124 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5124 Gln Ser Ile Ser Ser Trp 1 5 <210> 5125 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5125 aaggcgtct 9 <210> 5126 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5126 Lys Ala Ser 1 <210> 5127 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5127 caacactata atagttattc tccgacg 27 <210> 5128 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5128 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5129 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5129 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgaactgggt ccgacaagct 120 ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gtagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 5130 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5130 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 5131 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5131 ggattcacct ttgatgatta tgcc 24 <210> 5132 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5132 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5133 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5133 attagttgga atagtggtag cata 24 <210> 5134 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5134 Ile Ser Trp Asn Ser Gly Ser Ile 1 5 <210> 5135 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5135 gcaaaagatg gggtagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 5136 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5136 Ala Lys Asp Gly Val Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5137 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5137 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaaggtcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacac tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5138 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5138 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5139 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5139 cagagtatta gtagctgg 18 <210> 5140 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5140 Gln Ser Ile Ser Ser Trp 1 5 <210> 5141 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5141 aaggcgtct 9 <210> 5142 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5142 Lys Ala Ser 1 <210> 5143 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5143 caacactata atagttattc tccgacg 27 <210> 5144 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5144 Gln His Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5145 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5145 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattttgcca tgaactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtctcaggt attacttgga atagtggtag catagggtat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctatat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatggg 300 gcagtagtag cagctgctac ttcctactgg tacttcgatc tctggggccg tggcaccctg 360 gtcaccgtct cctca 375 <210> 5146 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5146 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 100 105 110 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 5147 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5147 ggattcacct ttgatgattt tgcc 24 <210> 5148 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5148 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 5149 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5149 attacttgga atagtggtag cata 24 <210> 5150 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5150 Ile Thr Trp Asn Ser Gly Ser Ile 1 5 <210> 5151 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5151 gcaaaagatg gggcagtagt agcagctgct acttcctact ggtacttcga tctc 54 <210> 5152 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5152 Ala Lys Asp Gly Ala Val Val Ala Ala Ala Thr Ser Tyr Trp Tyr Phe 1 5 10 15 Asp Leu <210> 5153 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5153 gacatcctga tgacccagtc tccttccacc ctgtctacat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag tataatagtt attctccgac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5154 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5154 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Thr Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5155 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5155 cagagtatta gtagctgg 18 <210> 5156 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5156 Gln Ser Ile Ser Ser Trp 1 5 <210> 5157 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5157 aaggcgtct 9 <210> 5158 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5158 Lys Ala Ser 1 <210> 5159 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5159 caacagtata atagttattc tccgacg 27 <210> 5160 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5160 Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 1 5 <210> 5161 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5161 gaggtgcagc tggtggagtc tggagcagaa gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacttttatc acctactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatat 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt atttctgtgc gagactcgaa 300 aaaataactt taaagggggg cggtatggac gtctgggccc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5162 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5162 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ile Thr Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 85 90 95 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val Trp 100 105 110 Ala Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5163 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5163 ggatacactt ttatcaccta ctgg 24 <210> 5164 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5164 Gly Tyr Thr Phe Ile Thr Tyr Trp 1 5 <210> 5165 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5165 atctatcctg gtgactctga tacc 24 <210> 5166 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5166 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 5167 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5167 gcgagactcg aaaaaataac tttaaagggg ggcggtatgg acgtc 45 <210> 5168 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5168 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val 1 5 10 15 <210> 5169 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5169 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc ggccaagtca gaccattagc agatatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct catctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5170 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5170 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Thr Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5171 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5171 cagaccatta gcagatat 18 <210> 5172 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5172 Gln Thr Ile Ser Arg Tyr 1 5 <210> 5173 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5173 actgcatcc 9 <210> 5174 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5174 Thr Ala Ser 1 <210> 5175 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5175 caacagagtt acagtatccc gtacact 27 <210> 5176 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5176 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 5177 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5177 caggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatt 60 tcctgtaagg gttctggata cagttttatc acctattgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctaa taccagatat 180 agcccgtcct tccaaggcca ggtcaccatg tcagccgaca agtccatcaa caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatat attactgtgc gagactcgaa 300 aaaataactt taaagggggg cggtatggac gtctgggccc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5178 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5178 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Thr Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asn Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val Trp 100 105 110 Ala Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5179 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5179 ggatacagtt ttatcaccta ttgg 24 <210> 5180 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5180 Gly Tyr Ser Phe Ile Thr Tyr Trp 1 5 <210> 5181 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5181 atctatcctg gtgactctaa tacc 24 <210> 5182 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5182 Ile Tyr Pro Gly Asp Ser Asn Thr 1 5 <210> 5183 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5183 gcgagactcg aaaaaataac tttaaagggg ggcggtatgg acgtc 45 <210> 5184 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5184 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val 1 5 10 15 <210> 5185 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5185 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc ggccaagtca gaccattagc cgctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ttccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5186 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5186 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Thr Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5187 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5187 cagaccatta gccgctat 18 <210> 5188 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5188 Gln Thr Ile Ser Arg Tyr 1 5 <210> 5189 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5189 actgcatcc 9 <210> 5190 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5190 Thr Ala Ser 1 <210> 5191 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5191 caacagagtt acagtattcc gtacact 27 <210> 5192 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5192 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 5193 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5193 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatgag caccgcctac 240 ctgcagtgga gcagtctgaa ggcctcggac accgccatgt attattgtgc gagactcgaa 300 gctataacta gaaaggaggg cgctatggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5194 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5194 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Met Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Leu Glu Ala Ile Thr Arg Lys Glu Gly Ala Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5195 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5195 ggatacagct ttaccagcta ctgg 24 <210> 5196 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5196 Gly Tyr Ser Phe Thr Ser Tyr Trp 1 5 <210> 5197 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5197 atctatcctg gtgactctga tacc 24 <210> 5198 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5198 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 5199 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5199 gcgagactcg aagctataac tagaaaggag ggcgctatgg acgtc 45 <210> 5200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5200 Ala Arg Leu Glu Ala Ile Thr Arg Lys Glu Gly Ala Met Asp Val 1 5 10 15 <210> 5201 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5201 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc ggacaagtca gtacattagc cgctatttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ccccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5202 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5202 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Tyr Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5203 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5203 cagtacatta gccgctat 18 <210> 5204 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5204 Gln Tyr Ile Ser Arg Tyr 1 5 <210> 5205 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5205 ggtgcatcc 9 <210> 5206 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5206 Gly Ala Ser 1 <210> 5207 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5207 caacagagtt acagtacccc gtacact 27 <210> 5208 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5208 Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 5209 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5209 caggtgcagc tggtggagtc tgggggagac ttggtacagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttaac aactatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtgata gtggtattgg cacgtactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtctg 300 ttcgggacct actacgccct ctttgactac tggggccagg gaaccccggt caccgtctcc 360 tca 363 <210> 5210 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5210 Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Asp Ser Gly Ile Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Phe Gly Thr Tyr Tyr Ala Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Pro Val Thr Val Ser Ser 115 120 <210> 5211 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5211 ggattcacct ttaacaacta tgcc 24 <210> 5212 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5212 Gly Phe Thr Phe Asn Asn Tyr Ala 1 5 <210> 5213 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5213 attagtgata gtggtattgg cacg 24 <210> 5214 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5214 Ile Ser Asp Ser Gly Ile Gly Thr 1 5 <210> 5215 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5215 gcgaaaggtc tgttcgggac ctactacgcc ctctttgact ac 42 <210> 5216 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5216 Ala Lys Gly Leu Phe Gly Thr Tyr Tyr Ala Leu Phe Asp Tyr 1 5 10 <210> 5217 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5217 gacatcctga tgacccagtc tccatcttcc gtgtctgcat ctgttggaga cagagtcacc 60 atcacttgtc gggcgagtca ggatattagc agctggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgtt gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttactt ttgtcaacag gctaacagtt tcccgatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 5218 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5218 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asn Ser Phe Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 5219 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5219 caggatatta gcagctgg 18 <210> 5220 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5220 Gln Asp Ile Ser Ser Trp 1 5 <210> 5221 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5221 gttgcatcc 9 <210> 5222 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5222 Val Ala Ser 1 <210> 5223 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5223 caacaggcta acagtttccc gatcacc 27 <210> 5224 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5224 Gln Gln Ala Asn Ser Phe Pro Ile Thr 1 5 <210> 5225 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5225 caggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc 60 tcctgtgcag cctctggatt cactttcact aacgcctgga tgagctgggt ccgccagact 120 ccagggaagg ggctggagtg gattggccgt attagaagca aagctgatgg tgggacaaca 180 gactgcgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacacg 240 ctgtatctgg aaatgaatag cctgaaaatc gaggacacag ccgtttatta ttgtaccata 300 gacccccata actggaggta ctactactac gttatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 5226 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5226 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Arg Ser Lys Ala Asp Gly Gly Thr Thr Asp Cys Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Glu Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Ile Asp Pro His Asn Trp Arg Tyr Tyr Tyr Tyr Val Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5227 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5227 ggattcactt tcactaacgc ctgg 24 <210> 5228 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5228 Gly Phe Thr Phe Thr Asn Ala Trp 1 5 <210> 5229 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5229 attagaagca aagctgatgg tgggacaaca 30 <210> 5230 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5230 Ile Arg Ser Lys Ala Asp Gly Gly Thr Thr 1 5 10 <210> 5231 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5231 accatagacc cccataactg gaggtactac tactacgtta tggacgtc 48 <210> 5232 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5232 Thr Ile Asp Pro His Asn Trp Arg Tyr Tyr Tyr Tyr Val Met Asp Val 1 5 10 15 <210> 5233 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5233 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcaataga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag tctgcagcct 240 gaagattttg caacttatta ctgtctactg cataatgatt actggacgtt cggccaaggg 300 accaaggtgg agatcaaacg a 321 <210> 5234 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5234 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Asn Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Leu His Asn Asp Tyr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5235 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5235 cagggcaata gaaatgat 18 <210> 5236 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5236 Gln Gly Asn Arg Asn Asp 1 5 <210> 5237 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5237 gctgcatcc 9 <210> 5238 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5238 Ala Ala Ser 1 <210> 5239 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5239 ctactgcata atgattactg gacg 24 <210> 5240 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5240 Leu Leu His Asn Asp Tyr Trp Thr 1 5 <210> 5241 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5241 caggtgcagc tggtggagtc tggagtagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aaatactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tatcagatac 180 agtccgtcct tccagggcca ggtcactatt tcagccgaca agtccaacaa caccgccttc 240 cttcactgga gcagcctgaa ggcctcggac accgccattt attactgtgc gagactcgaa 300 actataactg ggaaacaggg cggtatggtc gtctggggcc gagggaccac ggtcaccgtc 360 tcctca 366 <210> 5242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5242 Gln Val Gln Leu Val Glu Ser Gly Val Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Lys Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Asn Asn Thr Ala Phe 65 70 75 80 Leu His Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Leu Glu Thr Ile Thr Gly Lys Gln Gly Gly Met Val Val Trp 100 105 110 Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5243 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5243 ggatacacct ttaccaaata ctgg 24 <210> 5244 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5244 Gly Tyr Thr Phe Thr Lys Tyr Trp 1 5 <210> 5245 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5245 atctatcctg gtgactctga tatc 24 <210> 5246 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5246 Ile Tyr Pro Gly Asp Ser Asp Ile 1 5 <210> 5247 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5247 gcgagactcg aaactataac tgggaaacag ggcggtatgg tcgtc 45 <210> 5248 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5248 Ala Arg Leu Glu Thr Ile Thr Gly Lys Gln Gly Gly Met Val Val 1 5 10 15 <210> 5249 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5249 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcaagtca gagtattagt aggtatttaa attggtatca gcagaaacca 120 gggaaagccc caaacctcct catctatggt gcatccggtt ttcaaagtgg ggtcccatca 180 aggatcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caaattatta ctgtcaacag agttacagta cccccacttt cggcggaggg 300 accaaggtgg agatcaaacg a 321 <210> 5250 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5250 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Gly Phe Gln Ser Gly Val Pro Ser Arg Ile Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Asn Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5251 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5251 cagagtatta gtaggtat 18 <210> 5252 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5252 Gln Ser Ile Ser Arg Tyr 1 5 <210> 5253 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5253 ggtgcatcc 9 <210> 5254 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5254 Gly Ala Ser 1 <210> 5255 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5255 caacagagtt acagtacccc cact 24 <210> 5256 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5256 Gln Gln Ser Tyr Ser Thr Pro Thr 1 5 <210> 5257 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5257 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatt 60 tcctgtaagg gttctggata cagttttatc acctactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctaa taccagatat 180 agcccgtcct tccaaggcca ggtcaccatg tcagccgaca agtccatcaa caccgcctac 240 ctacagtgga gcagcctgaa ggcctcggac accgccatat attactgtgc gagactcgaa 300 aaaataactt taaagggggg cggtatggac gtctgggccc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5258 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5258 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Thr Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asn Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val Trp 100 105 110 Ala Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5259 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5259 ggatacagtt ttatcaccta ctgg 24 <210> 5260 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5260 Gly Tyr Ser Phe Ile Thr Tyr Trp 1 5 <210> 5261 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5261 atctatcctg gtgactctaa tacc 24 <210> 5262 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5262 Ile Tyr Pro Gly Asp Ser Asn Thr 1 5 <210> 5263 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5263 gcgagactcg aaaaaataac tttaaagggg ggcggtatgg acgtc 45 <210> 5264 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5264 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val 1 5 10 15 <210> 5265 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5265 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc ggccaagtca gaccattagc cactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacagta ttccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5266 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5266 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Thr Ile Ser His Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5267 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5267 cagaccatta gccactat 18 <210> 5268 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5268 Gln Thr Ile Ser His Tyr 1 5 <210> 5269 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5269 actgcatcc 9 <210> 5270 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5270 Thr Ala Ser 1 <210> 5271 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5271 caacagagtt acagtattcc gtacact 27 <210> 5272 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5272 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 5273 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5273 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgtag cgtctggatt caccttcagt acctatggca tgcattgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcactt atttggtatg atggaagtaa taaaaattat 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctggat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt atcactgtgt gagagcctcc 300 tatggttcca ggggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca 357 <210> 5274 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5274 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95 Val Arg Ala Ser Tyr Gly Ser Arg Gly Met Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 5275 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5275 ggattcacct tcagtaccta tggc 24 <210> 5276 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5276 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 5277 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5277 atttggtatg atggaagtaa taaa 24 <210> 5278 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5278 Ile Trp Tyr Asp Gly Ser Asn Lys 1 5 <210> 5279 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5279 gtgagagcct cctatggttc caggggtatg gacgtc 36 <210> 5280 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5280 Val Arg Ala Ser Tyr Gly Ser Arg Gly Met Asp Val 1 5 10 <210> 5281 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5281 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttgc actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactcca 300 ttcactttcg gccctgggac caaggtggag atcaaacga 339 <210> 5282 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5282 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 5283 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5283 cagagcctcc tgcatagtaa tggatacaac tat 33 <210> 5284 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5284 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 5285 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5285 ttgggttct 9 <210> 5286 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5286 Leu Gly Ser 1 <210> 5287 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5287 atgcaagctc tacaaactcc attcact 27 <210> 5288 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5288 Met Gln Ala Leu Gln Thr Pro Phe Thr 1 5 <210> 5289 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5289 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactact ggaactggat ccggcagtcc 120 ccagggaagg gactggaatg gattggttat atctatgaca gtgggaacac caaatacagt 180 ccctccctca agagtcgagt caccatatca gtggacacgt ccaagaacca cttctccctg 240 aagcttatct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agggagttac 300 gatattttga ctgcttatta tagtccctgg ttcgactcct ggggccaggg aaccctggtc 360 accgtctcct ca 372 <210> 5290 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5290 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Asp Ser Gly Asn Thr Lys Tyr Ser Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Lys Leu Ile Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Tyr Asp Ile Leu Thr Ala Tyr Tyr Ser Pro Trp Phe Asp 100 105 110 Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5291 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5291 ggtggctcca tcagtagtta ctac 24 <210> 5292 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5292 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 5293 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5293 atctatgaca gtgggaacac c 21 <210> 5294 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5294 Ile Tyr Asp Ser Gly Asn Thr 1 5 <210> 5295 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5295 gcgagaggga gttacgatat tttgactgct tattatagtc cctggttcga ctcc 54 <210> 5296 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5296 Ala Arg Gly Ser Tyr Asp Ile Leu Thr Ala Tyr Tyr Ser Pro Trp Phe 1 5 10 15 Asp Ser <210> 5297 <211> 342 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5297 gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60 atcaactgca agtccagcca gaatgtttta ttcaactcca acaataagaa gtacttagcc 120 tggtaccaga agaaaccagg acagcctcca aagttactca tttactgggc atctacccgg 180 gaatccggga tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240 atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact 300 ccgtggacgt tcggccaagg gaccaaggtg gagatcaaac ga 342 <210> 5298 <211> 114 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5298 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Val Leu Phe Asn 20 25 30 Ser Asn Asn Lys Lys Tyr Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln 35 40 45 Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile 50 55 60 Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 65 70 75 80 Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 85 90 95 Tyr Tyr Asn Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 100 105 110 Lys Arg <210> 5299 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5299 cagaatgttt tattcaactc caacaataag aagtac 36 <210> 5300 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5300 Gln Asn Val Leu Phe Asn Ser Asn Asn Lys Lys Tyr 1 5 10 <210> 5301 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5301 tgggcatct 9 <210> 5302 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5302 Trp Ala Ser 1 <210> 5303 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5303 cagcaatatt ataatactcc gtggacg 27 <210> 5304 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5304 Gln Gln Tyr Tyr Asn Thr Pro Trp Thr 1 5 <210> 5305 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5305 caggtgcagc tggtggagtc gggtccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcaatg tctctggtgg ctccatcagt ggttacttct ggagttggat ccggcagtcc 120 ccagggaagg aactggagtg gattggatat atctattaca gtgggagcac caactacaat 180 ccctccctcg agagtcgcgt caccatgtca gtagacacga ccaataacca ggtctccctg 240 aggctgagtt ctgtgaccgc tgaggacacg gccgtgtatt tctgtgcgag agatgatgca 300 gactacaacg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca 354 <210> 5306 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5306 Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Asn Val Ser Gly Gly Ser Ile Ser Gly Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Glu Leu Glu Trp Ile 35 40 45 Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Glu 50 55 60 Ser Arg Val Thr Met Ser Val Asp Thr Thr Asn Asn Gln Val Ser Leu 65 70 75 80 Arg Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val Trp Gly Gln Gly Thr 100 105 110 Thr Val Thr Val Ser Ser 115 <210> 5307 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5307 ggtggctcca tcagtggtta cttc 24 <210> 5308 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5308 Gly Gly Ser Ile Ser Gly Tyr Phe 1 5 <210> 5309 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5309 atctattaca gtgggagcac c 21 <210> 5310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5310 Ile Tyr Tyr Ser Gly Ser Thr 1 5 <210> 5311 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5311 gcgagagatg atgcagacta caacggtatg gacgtc 36 <210> 5312 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5312 Ala Arg Asp Asp Ala Asp Tyr Asn Gly Met Asp Val 1 5 10 <210> 5313 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5313 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccttggaca ggcggcctcc 60 atctcctgca ggtctagtca aagcctcctc tacagtgatg gaaaaatata cttgagttgg 120 tttcaccaga ggccaggcca acctccaagg cgcctaattt ataaggtttc taagcgggac 180 tctggggtcc cagacagatt cggcggcagt gggtcagaca gtgacttcac actgaaaatc 240 agcagggtgg aggctgagga tgttgggatt tattactgca tgcaaggtac acactggccg 300 ctcactttcg gcggagggac caaggtggag atcaaacga 339 <210> 5314 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5314 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 1 5 10 15 Gln Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 20 25 30 Asp Gly Lys Ile Tyr Leu Ser Trp Phe His Gln Arg Pro Gly Gln Pro 35 40 45 Pro Arg Arg Leu Ile Tyr Lys Val Ser Lys Arg Asp Ser Gly Val Pro 50 55 60 Asp Arg Phe Gly Gly Ser Gly Ser Asp Ser Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly 85 90 95 Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 5315 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5315 caaagcctcc tctacagtga tggaaaaata tac 33 <210> 5316 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5316 Gln Ser Leu Leu Tyr Ser Asp Gly Lys Ile Tyr 1 5 10 <210> 5317 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5317 aaggtttct 9 <210> 5318 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5318 Lys Val Ser 1 <210> 5319 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5319 atgcaaggta cacactggcc gctcact 27 <210> 5320 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5320 Met Gln Gly Thr His Trp Pro Leu Thr 1 5 <210> 5321 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5321 gaggtgcagc tggtggagtc tgggggagac ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttaac agctatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct gttagtaata ctggttctgg cacgtactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg agccgaggac acggccgtat attactgtgc gaaaggtctg 300 ttcgggacct actacgccct ctttgactac tggggccagg gaaccacggt caccgtctcc 360 tca 363 <210> 5322 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5322 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Val Ser Asn Thr Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Phe Gly Thr Tyr Tyr Ala Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5323 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5323 ggattcacct ttaacagcta tgcc 24 <210> 5324 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5324 Gly Phe Thr Phe Asn Ser Tyr Ala 1 5 <210> 5325 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5325 gttagtaata ctggttctgg cacg 24 <210> 5326 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5326 Val Ser Asn Thr Gly Ser Gly Thr 1 5 <210> 5327 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5327 gcgaaaggtc tgttcgggac ctactacgcc ctctttgact ac 42 <210> 5328 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5328 Ala Lys Gly Leu Phe Gly Thr Tyr Tyr Ala Leu Phe Asp Tyr 1 5 10 <210> 5329 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5329 gacatcctga tgacccagtc tccatcttcc gtgtctgcat ctgttggaga cagagtcacc 60 atcacttgtc gggcgagtca ggatattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgtt gcatccaatt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctct ccatcaacag cctgcagcct 240 gaagattttg caacttactt ttgtcaacag gctaacagtt tcccgatcac cttcggccaa 300 gggaccaaac tggagatcaa acga 324 <210> 5330 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5330 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Asn Ser Phe Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 100 105 <210> 5331 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5331 caggatatta gcagttgg 18 <210> 5332 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5332 Gln Asp Ile Ser Ser Trp 1 5 <210> 5333 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5333 gttgcatcc 9 <210> 5334 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5334 Val Ala Ser 1 <210> 5335 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5335 caacaggcta acagtttccc gatcacc 27 <210> 5336 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5336 Gln Gln Ala Asn Ser Phe Pro Ile Thr 1 5 <210> 5337 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5337 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cagttttatc acttattgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccatg tcagccgaca agtccatcaa taccgcctac 240 cttcagtgga gtagtctgaa ggcctcggac accgccattt attactgtgc gagactcgaa 300 aaaataactt taaagggggg cggtatggac gtctgggccc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5338 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5338 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Thr Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val Trp 100 105 110 Ala Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5339 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5339 ggatacagtt ttatcactta ttgg 24 <210> 5340 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5340 Gly Tyr Ser Phe Ile Thr Tyr Trp 1 5 <210> 5341 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5341 atctatcctg gtgactctga tacc 24 <210> 5342 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5342 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 5343 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5343 gcgagactcg aaaaaataac tttaaagggg ggcggtatgg acgtc 45 <210> 5344 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5344 Ala Arg Leu Glu Lys Ile Thr Leu Lys Gly Gly Gly Met Asp Val 1 5 10 15 <210> 5345 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5345 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattagc aggtatttaa attggtatca gcataaacca 120 gggaaagccc ctaaactcct gatctatact gcatcaagtt tacaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ttgtcaacag agttacaata tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5346 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5346 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5347 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5347 cagaccatta gcaggtat 18 <210> 5348 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5348 Gln Thr Ile Ser Arg Tyr 1 5 <210> 5349 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5349 actgcatca 9 <210> 5350 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5350 Thr Ala Ser 1 <210> 5351 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5351 caacagagtt acaatatccc gtacact 27 <210> 5352 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5352 Gln Gln Ser Tyr Asn Ile Pro Tyr Thr 1 5 <210> 5353 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5353 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggtg gcggtagtac cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat atttctgtgc gattagagga 300 tacaactatg gtcctgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 5354 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5354 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Gly Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ile Arg Gly Tyr Asn Tyr Gly Pro Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 5355 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5355 ggattcacct ttagcagcta tgcc 24 <210> 5356 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5356 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 5357 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5357 attagtggtg gcggtagtac caca 24 <210> 5358 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5358 Ile Ser Gly Gly Gly Ser Thr Thr 1 5 <210> 5359 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5359 gcgattagag gatacaacta tggtcctgac tac 33 <210> 5360 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5360 Ala Ile Arg Gly Tyr Asn Tyr Gly Pro Asp Tyr 1 5 10 <210> 5361 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5361 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag tctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccgtca 180 aggttcagcg gcactggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt accccacgtg gacgttcggc 300 caagggacca aggtggagat caaacga 327 <210> 5362 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5362 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Thr 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5363 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5363 cagggcatta gaaatgat 18 <210> 5364 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5364 Gln Gly Ile Arg Asn Asp 1 5 <210> 5365 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5365 gctgcatcc 9 <210> 5366 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5366 Ala Ala Ser 1 <210> 5367 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5367 ctacaagatt acaattaccc cacgtggacg 30 <210> 5368 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5368 Leu Gln Asp Tyr Asn Tyr Pro Thr Trp Thr 1 5 10 <210> 5369 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5369 gaggtgcagc tggtggagtc tgggggagac ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttaac agctatgcca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctacaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtctg 300 ttcgggacct actacgccct ctttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 5370 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5370 Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Phe Gly Thr Tyr Tyr Ala Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5371 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5371 ggattcacct ttaacagcta tgcc 24 <210> 5372 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5372 Gly Phe Thr Phe Asn Ser Tyr Ala 1 5 <210> 5373 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5373 attagtggta gtggtggtag caca 24 <210> 5374 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5374 Ile Ser Gly Ser Gly Gly Ser Thr 1 5 <210> 5375 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5375 gcgaaaggtc tgttcgggac ctactacgcc ctctttgact ac 42 <210> 5376 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5376 Ala Lys Gly Leu Phe Gly Thr Tyr Tyr Ala Leu Phe Asp Tyr 1 5 10 <210> 5377 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5377 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattagc agctatttac attggtatca gcagaaacca 120 gggaaggccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatttgg aaattaatcc tgtcaacaaa gttacagtat tccccttttt cggcggaggg 300 accaaggtgg agatcaaacg a 321 <210> 5378 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5378 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Ser Tyr 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Glu Ile Asn Pro Val Asn Lys Val Thr Val Phe Pro Phe 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5379 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5379 cagaacatta gcagctat 18 <210> 5380 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5380 Gln Asn Ile Ser Ser Tyr 1 5 <210> 5381 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5381 gctgcatcc 9 <210> 5382 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5382 Ala Ala Ser 1 <210> 5383 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5383 caacaaagtt acagtattcc cctt 24 <210> 5384 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5384 Gln Gln Ser Tyr Ser Ile Pro Leu 1 5 <210> 5385 <211> 384 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5385 gaggtgcagc tggtggagtc tgggggaggg atggtccagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagt agttattgga tgagttgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaaacaag atggtagtga agaattctat 180 gtggactctg tgacgggccg attcaccatc tccagagacg acgccaagaa atcactgtat 240 ctgcaaatga ggagcctgag agccgaggac acggctgtgt attactgtgc gagagagagc 300 ccgtatagta gtagttggta tggaccatat tactactatg gtatggacgt ctggggccaa 360 gggaccacgg tcaccgtctc ctca 384 <210> 5386 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5386 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser Glu Glu Phe Tyr Val Asp Ser Val 50 55 60 Thr Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Lys Ser Leu Tyr 65 70 75 80 Leu Gln Met Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ser Pro Tyr Ser Ser Ser Trp Tyr Gly Pro Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5387 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5387 ggattcacct ttagtagtta ttgg 24 <210> 5388 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5388 Gly Phe Thr Phe Ser Ser Tyr Trp 1 5 <210> 5389 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5389 ataaaacaag atggtagtga agaa 24 <210> 5390 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5390 Ile Lys Gln Asp Gly Ser Glu Glu 1 5 <210> 5391 <211> 63 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5391 gcgagagaga gcccgtatag tagtagttgg tatggaccat attactacta tggtatggac 60 gtc 63 <210> 5392 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5392 Ala Arg Glu Ser Pro Tyr Ser Ser Ser Trp Tyr Gly Pro Tyr Tyr Tyr 1 5 10 15 Tyr Gly Met Asp Val 20 <210> 5393 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5393 gacatcgtga tgacccagtc tccagccacc ctatctatgt ctccagggga aagagtcacc 60 ctctcctgca gggccagtca aaatattggc atcaacttag tctggtacca gcggaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg gatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccgtcagcag cctgcagtct 240 gaagattttg caatttatta ttgtcagcag tataatgact ggcccacttt cggcggaggg 300 accaaggtgg agatcaaacg a 321 <210> 5394 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5394 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Met Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Gly Ile Asn 20 25 30 Leu Val Trp Tyr Gln Arg Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5395 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5395 caaaatattg gcatcaac 18 <210> 5396 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5396 Gln Asn Ile Gly Ile Asn 1 5 <210> 5397 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5397 ggtgcatcc 9 <210> 5398 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5398 Gly Ala Ser 1 <210> 5399 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5399 cagcagtata atgactggcc cact 24 <210> 5400 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5400 Gln Gln Tyr Asn Asp Trp Pro Thr 1 5 <210> 5401 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5401 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aaatactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatat 180 agcccgtcct tccagggcca ggtcaccatt tcagccgaca attccatcaa caccgcctac 240 ctacactgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagactcgaa 300 actataactg gaaaacaggg cggtatggtc gtctggggcc aagggaccat ggtcaccgtc 360 tcctca 366 <210> 5402 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5402 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Lys Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Asn Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu His Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Leu Glu Thr Ile Thr Gly Lys Gln Gly Gly Met Val Val Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5403 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5403 ggatacacct ttaccaaata ctgg 24 <210> 5404 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5404 Gly Tyr Thr Phe Thr Lys Tyr Trp 1 5 <210> 5405 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5405 atctatcctg gtgactctga tacc 24 <210> 5406 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5406 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 5407 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5407 gcgagactcg aaactataac tggaaaacag ggcggtatgg tcgtc 45 <210> 5408 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5408 Ala Arg Leu Glu Thr Ile Thr Gly Lys Gln Gly Gly Met Val Val 1 5 10 15 <210> 5409 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5409 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atctcttgtc gggcaagtca gagtattagt aggtatttaa attggtatca gcagaaacca 120 gggaaagccc caaacctcct gatctatggt gtatccggtt ttcaaagtgg ggtcccatta 180 aggatcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caaattacta ctgtcaacag agttatagta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5410 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5410 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Gly Val Ser Gly Phe Gln Ser Gly Val Pro Leu Arg Ile Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Asn Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5411 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5411 cagagtatta gtaggtat 18 <210> 5412 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5412 Gln Ser Ile Ser Arg Tyr 1 5 <210> 5413 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5413 ggtgtatcc 9 <210> 5414 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5414 Gly Val Ser 1 <210> 5415 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5415 caacagagtt atagtatccc gtacact 27 <210> 5416 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5416 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 5417 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5417 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggtg gcggtagtac cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat atttctgtgc gattagagga 300 tacaactatg gtcctgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 5418 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5418 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Gly Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Ile Arg Gly Tyr Asn Tyr Gly Pro Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 5419 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5419 ggattcacct ttagcagcta tgcc 24 <210> 5420 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5420 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 5421 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5421 attagtggtg gcggtagtac caca 24 <210> 5422 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5422 Ile Ser Gly Gly Gly Ser Thr Thr 1 5 <210> 5423 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5423 gcgattagag gatacaacta tggtcctgac tac 33 <210> 5424 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5424 Ala Ile Arg Gly Tyr Asn Tyr Gly Pro Asp Tyr 1 5 10 <210> 5425 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5425 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag tctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccgtca 180 aggttcagcg gcactggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt accccacgtg gacgttcggc 300 caagggacca aggtggagat caaacga 327 <210> 5426 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5426 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Thr 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5427 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5427 cagggcatta gaaatgat 18 <210> 5428 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5428 Gln Gly Ile Arg Asn Asp 1 5 <210> 5429 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5429 gctgcatcc 9 <210> 5430 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5430 Ala Ala Ser 1 <210> 5431 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5431 ctacaagatt acaattaccc cacgtggacg 30 <210> 5432 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5432 Leu Gln Asp Tyr Asn Tyr Pro Thr Trp Thr 1 5 10 <210> 5433 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5433 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt acttactatt ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgaact ctgtgaccgc cgcggacacg tctgtatatt actgtgcgag aggccctagt 300 acattaacta cagactacta cggtttggac gtctggggcc aagggaccat ggtcaccgtc 360 tcctca 366 <210> 5434 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5434 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ser Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Ser Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5435 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5435 ggtgggtcct tcagtactta ctat 24 <210> 5436 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5436 Gly Gly Ser Phe Ser Thr Tyr Tyr 1 5 <210> 5437 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5437 atcaatcata ctggaagcac c 21 <210> 5438 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5438 Ile Asn His Thr Gly Ser Thr 1 5 <210> 5439 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5439 gcgagaggcc ctagtacatt aactacagac tactacggtt tggacgtc 48 <210> 5440 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5440 Ala Arg Gly Pro Ser Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 5441 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5441 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5442 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5442 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5443 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5443 caggacatta gcaactat 18 <210> 5444 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5444 Gln Asp Ile Ser Asn Tyr 1 5 <210> 5445 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5445 gatgcatcc 9 <210> 5446 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5446 Asp Ala Ser 1 <210> 5447 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5447 caacagtatg ataatctccc gctcact 27 <210> 5448 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5448 Gln Gln Tyr Asp Asn Leu Pro Leu Thr 1 5 <210> 5449 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5449 gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgacttgggt ccgccaagct 120 ccagggaagg ggctggagtg ggtctctggt attaattgga gtggtgatag aataggatat 180 gcagactctg tgaggggccg attcaccatc tccagagaca acgccaagaa ctccctattt 240 ctgcaaatga acagtctgag agccgaggac acggccttgt atcactgtgc gagagatagg 300 gatggaggtc ctccttccta cttctactac ggtatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 5450 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5450 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Ser Gly Asp Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr His Cys 85 90 95 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Tyr Phe Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5451 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5451 ggattcacct ttgatgatta tgcc 24 <210> 5452 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5452 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5453 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5453 attaattgga gtggtgatag aata 24 <210> 5454 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5454 Ile Asn Trp Ser Gly Asp Arg Ile 1 5 <210> 5455 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5455 gcgagagata gggatggagg tcctccttcc tacttctact acggtatgga cgtc 54 <210> 5456 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5456 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Tyr Phe Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 5457 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5457 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatatta ctgtcaacag tatgataatc tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 5458 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5458 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5459 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5459 caggacatta gcaactat 18 <210> 5460 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5460 Gln Asp Ile Ser Asn Tyr 1 5 <210> 5461 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5461 gatgcatcc 9 <210> 5462 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5462 Asp Ala Ser 1 <210> 5463 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5463 caacagtatg ataatctccc gtacact 27 <210> 5464 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5464 Gln Gln Tyr Asp Asn Leu Pro Tyr Thr 1 5 <210> 5465 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5465 gaggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcaat tattactact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcactcata gtggaatcac caacaaaaac 180 ccgtccctca agagtcgagt cactatatca gtagacacgt ccaagaacca gttgtccctg 240 aaactgaact ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag aggaaagatt 300 gaagcagctg tctctgattc ttttgatata tggggccaag ggacaatggt caccgtctct 360 tca 363 <210> 5466 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5466 Glu Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Tyr Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Thr His Ser Gly Ile Thr Asn Lys Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Lys Ile Glu Ala Ala Val Ser Asp Ser Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5467 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5467 ggtgggtcct tcaattatta ctac 24 <210> 5468 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5468 Gly Gly Ser Phe Asn Tyr Tyr Tyr 1 5 <210> 5469 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5469 atcactcata gtggaatcac c 21 <210> 5470 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5470 Ile Thr His Ser Gly Ile Thr 1 5 <210> 5471 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5471 gcgagaggaa agattgaagc agctgtctct gattcttttg atata 45 <210> 5472 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5472 Ala Arg Gly Lys Ile Glu Ala Ala Val Ser Asp Ser Phe Asp Ile 1 5 10 15 <210> 5473 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5473 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgta gggtcagtca gagtgttagc agtagttact cagcctggta ccagcagaaa 120 cctggccagg ctcccagact cctcatctat ggtgcatcca gcagggccgc tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgctgtgta ttactgtcag cagtttggtg actcattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5474 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5474 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Val Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Asp Ser Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5475 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5475 cagagtgtta gcagtagtta c 21 <210> 5476 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5476 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 5477 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5477 ggtgcatcc 9 <210> 5478 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5478 Gly Ala Ser 1 <210> 5479 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5479 cagcagtttg gtgactcatt cact 24 <210> 5480 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5480 Gln Gln Phe Gly Asp Ser Phe Thr 1 5 <210> 5481 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5481 caggtgcagc tggtggagtc tgggggaggc ttggtacagg ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cccctttaga agttatgcca tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtacta gtggtggtag cacatattac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga acagcctgag agtcgatgac acggccgttt attactgtgc gaaagatctg 300 ggggccctcg gctactacta tggtattgac gtctggggcc aggggaccac ggtcaccgtc 360 tcctca 366 <210> 5482 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5482 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Arg Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Leu Gly Ala Leu Gly Tyr Tyr Tyr Gly Ile Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5483 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5483 ggattcccct ttagaagtta tgcc 24 <210> 5484 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5484 Gly Phe Pro Phe Arg Ser Tyr Ala 1 5 <210> 5485 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5485 attagtacta gtggtggtag caca 24 <210> 5486 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5486 Ile Ser Thr Ser Gly Gly Ser Thr 1 5 <210> 5487 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5487 gcgaaagatc tgggggccct cggctactac tatggtattg acgtc 45 <210> 5488 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5488 Ala Lys Asp Leu Gly Ala Leu Gly Tyr Tyr Tyr Gly Ile Asp Val 1 5 10 15 <210> 5489 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5489 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aggagccacc 60 ctctcctgca gggccagtca gagtgttagc aactacttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggtcagac ttcactctca ccatcagcag ccttgagcct 240 gaggattttg cagtttattc ttgtcagcag cgtagcaact ggccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5490 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5490 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Arg Ser Asn Trp Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5491 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5491 cagagtgtta gcaactac 18 <210> 5492 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5492 Gln Ser Val Ser Asn Tyr 1 5 <210> 5493 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5493 gatgcatcc 9 <210> 5494 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5494 Asp Ala Ser 1 <210> 5495 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5495 cagcagcgta gcaactggcc gtggacg 27 <210> 5496 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5496 Gln Gln Arg Ser Asn Trp Pro Trp Thr 1 5 <210> 5497 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5497 gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc 120 ccagggaagg gactggagtg gattgcgtat atctataaca gtgggagaat caagtacaac 180 ccctccctca agagtcgagt caccatatca ggagacacgt ccaagaacca gttctccctg 240 aagttgacct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatcgcctg 300 tatagcagca gcccccactg gtacttcgat ctctggggcc gtggcaccat ggtcaccgtc 360 tcctca 366 <210> 5498 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5498 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ala Tyr Ile Tyr Asn Ser Gly Arg Ile Lys Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Arg Leu Tyr Ser Ser Ser Pro His Trp Tyr Phe Asp Leu Trp 100 105 110 Gly Arg Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5499 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5499 ggtggctcca tcagtagtta ctac 24 <210> 5500 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5500 Gly Gly Ser Ile Ser Ser Tyr Tyr 1 5 <210> 5501 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5501 atctataaca gtgggagaat c 21 <210> 5502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5502 Ile Tyr Asn Ser Gly Arg Ile 1 5 <210> 5503 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5503 gcgagagatc gcctgtatag cagcagcccc cactggtact tcgatctc 48 <210> 5504 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5504 Ala Arg Asp Arg Leu Tyr Ser Ser Ser Pro His Trp Tyr Phe Asp Leu 1 5 10 15 <210> 5505 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5505 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctttaggaga cagagtcagt 60 atcacttgcc gggccagtca gagcattagc acctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaatatcct gatctctgct gcatccagtt tgcaaagtgg ggtcccatca 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag agttacgata ccccgatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 5506 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5506 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Ile Leu Ile 35 40 45 Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 5507 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5507 cagagcatta gcacctat 18 <210> 5508 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5508 Gln Ser Ile Ser Thr Tyr 1 5 <210> 5509 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5509 gctgcatcc 9 <210> 5510 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5510 Ala Ala Ser 1 <210> 5511 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5511 caacagagtt acgatacccc gatcacc 27 <210> 5512 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5512 Gln Gln Ser Tyr Asp Thr Pro Ile Thr 1 5 <210> 5513 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5513 caggtgcagc tggtggagtc tgggggaggt gtggtccggc ctggggggtc cctaagactc 60 tcctgtgcag cctctggatt catctttgat gattatgcca tgatctgggt ccgccaagtt 120 ccagggaagg ggctgcagtg ggtctctggt attaattgga atggtggtaa tataggttat 180 gtagactttg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agtcgaggac acggccttgt attattgtgc gagagatagg 300 gatggaggtc ctccttcctt ttactactac ggtatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 5514 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5514 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr 20 25 30 Ala Met Ile Trp Val Arg Gln Val Pro Gly Lys Gly Leu Gln Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Gly Asn Ile Gly Tyr Val Asp Phe Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Phe Tyr Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5515 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5515 ggattcatct ttgatgatta tgcc 24 <210> 5516 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5516 Gly Phe Ile Phe Asp Asp Tyr Ala 1 5 <210> 5517 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5517 attaattgga atggtggtaa tata 24 <210> 5518 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5518 Ile Asn Trp Asn Gly Gly Asn Ile 1 5 <210> 5519 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5519 gcgagagata gggatggagg tcctccttcc ttttactact acggtatgga cgtc 54 <210> 5520 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5520 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Phe Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 5521 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5521 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gactattagc gactacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatgat tcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac tttactctca ccatcaccag cctagagcct 240 gaagattttg tagtttatta ctgtcagcag cgtagcacct ggccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5522 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5522 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Arg Ser Thr Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5523 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5523 cagactatta gcgactac 18 <210> 5524 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5524 Gln Thr Ile Ser Asp Tyr 1 5 <210> 5525 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5525 gattcatcc 9 <210> 5526 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5526 Asp Ser Ser 1 <210> 5527 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5527 cagcagcgta gcacctggcc gctcact 27 <210> 5528 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5528 Gln Gln Arg Ser Thr Trp Pro Leu Thr 1 5 <210> 5529 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5529 gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc 60 tcctgtgtag cctctggatt cacctttgat gattatgcca tgagctgggt ccgccaaggt 120 atagggaagg gactggagtg ggtctctggt attaattgga atggtgatag cacaggttat 180 gcagactctg tgaggggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agccgaggac acggccttgt attattgtgc gagagatagg 300 gatggaggtc ctccttcata ttactatttt gggatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 5530 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5530 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Gly Ile Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Tyr Tyr Tyr Phe Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5531 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5531 ggattcacct ttgatgatta tgcc 24 <210> 5532 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5532 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5533 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5533 attaattgga atggtgatag caca 24 <210> 5534 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5534 Ile Asn Trp Asn Gly Asp Ser Thr 1 5 <210> 5535 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5535 gcgagagata gggatggagg tcctccttca tattactatt ttgggatgga cgtc 54 <210> 5536 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5536 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Tyr Tyr Tyr Phe Gly Met 1 5 10 15 Asp Val <210> 5537 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5537 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gaatattaac gactacttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtatgtc tgggacagac ttcactctca ccatcagtag cctagagact 240 gaagattttg cagtttatta ctgtcagcag cgtagcaatc ggccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5538 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5538 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asp Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Met Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Thr 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Arg Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5539 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5539 cagaatatta acgactac 18 <210> 5540 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5540 Gln Asn Ile Asn Asp Tyr 1 5 <210> 5541 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5541 gatgcatcc 9 <210> 5542 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5542 Asp Ala Ser 1 <210> 5543 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5543 cagcagcgta gcaatcggcc gctcact 27 <210> 5544 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5544 Gln Gln Arg Ser Asn Arg Pro Leu Thr 1 5 <210> 5545 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5545 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctctccctc 60 acctgtgctg tctatggtgg gtccttcagt tcttcctact ggaactggat ccgccagtcc 120 ccagggaggg gactggagtg gattggggaa atctttcata gtggaaacac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca cttctccctg 240 aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggaaagata 300 gaatcggctg tttctgattc ttttgatatc tggggccaag ggacaatggt caccgtctcc 360 tca 363 <210> 5546 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5546 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Ser 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Phe His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Lys Ile Glu Ser Ala Val Ser Asp Ser Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5547 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5547 ggtgggtcct tcagttcttc ctac 24 <210> 5548 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5548 Gly Gly Ser Phe Ser Ser Ser Tyr 1 5 <210> 5549 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5549 atctttcata gtggaaacac c 21 <210> 5550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5550 Ile Phe His Ser Gly Asn Thr 1 5 <210> 5551 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5551 gcgagaggaa agatagaatc ggctgtttct gattcttttg atatc 45 <210> 5552 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5552 Ala Arg Gly Lys Ile Glu Ser Ala Val Ser Asp Ser Phe Asp Ile 1 5 10 15 <210> 5553 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5553 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagact ttgcagtgta tttctgtcag cagtatggaa gctcattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5554 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5554 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5555 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5555 cagagtgtta gcagcagcta c 21 <210> 5556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5556 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 5557 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5557 ggtacatcc 9 <210> 5558 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5558 Gly Thr Ser 1 <210> 5559 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5559 cagcagtatg gaagctcatt catt 24 <210> 5560 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5560 Gln Gln Tyr Gly Ser Ser Phe Ile 1 5 <210> 5561 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5561 gaggtgcagc tggtgcagtc tgggggaggt ttgatacagc ctgggggggc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agcgatgtca tgagttgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct atcagtagta gtggtgatag catatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga atggcctgag agccgaggac acggccatat attattgtgc gatagtaggt 300 aactatggtg acttcgccag gtggttcgac ccctggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 5562 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5562 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 20 25 30 Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Asp Ser Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Ile Val Gly Asn Tyr Gly Asp Phe Ala Arg Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5563 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5563 ggattcacct ttagcagcga tgtc 24 <210> 5564 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5564 Gly Phe Thr Phe Ser Ser Asp Val 1 5 <210> 5565 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5565 atcagtagta gtggtgatag cata 24 <210> 5566 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5566 Ile Ser Ser Ser Gly Asp Ser Ile 1 5 <210> 5567 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5567 gcgatagtag gtaactatgg tgacttcgcc aggtggttcg acccc 45 <210> 5568 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5568 Ala Ile Val Gly Asn Tyr Gly Asp Phe Ala Arg Trp Phe Asp Pro 1 5 10 15 <210> 5569 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5569 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gaacattaac aactatttaa attggtatca gcagaaacca 120 gggaaagccc cgaacctcct gatctatgct gcatccattt tgcaaaatgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ctgtcaacag agttacacta ccccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5570 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5570 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Thr Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5571 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5571 cagaacatta acaactat 18 <210> 5572 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5572 Gln Asn Ile Asn Asn Tyr 1 5 <210> 5573 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5573 gctgcatcc 9 <210> 5574 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5574 Ala Ala Ser 1 <210> 5575 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5575 caacagagtt acactacccc gctcact 27 <210> 5576 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5576 Gln Gln Ser Tyr Thr Thr Pro Leu Thr 1 5 <210> 5577 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5577 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt gcttcctact ggaactggat ccgccagccc 120 ccagggaggg gactggagtg gattggggaa atctttcata gtggaaacag caactacaat 180 ccgtccctca agagtcgagt caccatttca gtagacacgt ccaagaacca cttctccctg 240 aaactgagct ctgtgaccgc cgcggacacg gctatgtatt actgtgcgag aggaaagata 300 gaatcggctg tttctgatgc ttttgatatc tggggccaag ggacaatggt caccgtctct 360 tca 363 <210> 5578 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5578 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ala Ser 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Phe His Ser Gly Asn Ser Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 85 90 95 Arg Gly Lys Ile Glu Ser Ala Val Ser Asp Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5579 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5579 ggtgggtcct tcagtgcttc ctac 24 <210> 5580 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5580 Gly Gly Ser Phe Ser Ala Ser Tyr 1 5 <210> 5581 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5581 atctttcata gtggaaacag c 21 <210> 5582 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5582 Ile Phe His Ser Gly Asn Ser 1 5 <210> 5583 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5583 gcgagaggaa agatagaatc ggctgtttct gatgcttttg atatc 45 <210> 5584 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5584 Ala Arg Gly Lys Ile Glu Ser Ala Val Ser Asp Ala Phe Asp Ile 1 5 10 15 <210> 5585 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5585 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatttat ggtacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaggatt ttgcagtata tttctgtcag cagtatggta actcattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5586 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5586 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asn Ser Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5587 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5587 cagagtgtta gcagcagcta c 21 <210> 5588 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5588 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 5589 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5589 ggtacatcc 9 <210> 5590 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5590 Gly Thr Ser 1 <210> 5591 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5591 cagcagtatg gtaactcatt catt 24 <210> 5592 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5592 Gln Gln Tyr Gly Asn Ser Phe Ile 1 5 <210> 5593 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5593 caggtgcagc tggtgcagtg gggcgcagga ctgttgatgc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt tattactact ggacctggat ccgtcagccc 120 ccagggaaga gactggagtg gattggggag atcaatcata gtggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gttgacacgc ccaagagcca gttctccctg 240 aagctgatct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggaataata 300 acatcagctg tctctgatgc ttttgatatt tggggccaag ggacaatggt caccgtctcc 360 tca 363 <210> 5594 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5594 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Met Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Tyr Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Pro Lys Ser Gln Phe Ser Leu 65 70 75 80 Lys Leu Ile Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ile Ile Thr Ser Ala Val Ser Asp Ala Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5595 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5595 ggtgggtcct tcagttatta ctac 24 <210> 5596 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5596 Gly Gly Ser Phe Ser Tyr Tyr Tyr 1 5 <210> 5597 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5597 atcaatcata gtggaagcac c 21 <210> 5598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5598 Ile Asn His Ser Gly Ser Thr 1 5 <210> 5599 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5599 gcgagaggaa taataacatc agctgtctct gatgcttttg atatt 45 <210> 5600 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5600 Ala Arg Gly Ile Ile Thr Ser Ala Val Ser Asp Ala Phe Asp Ile 1 5 10 15 <210> 5601 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5601 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agtacctact tagcctggta ccagcagaga 120 cctggccagg ctcccaggct cctcatctat ggaacatcca ctagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag caatttggtg actcattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5602 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5602 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Asp Ser Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5603 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5603 cagagtgtta gcagtaccta c 21 <210> 5604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5604 Gln Ser Val Ser Ser Thr Tyr 1 5 <210> 5605 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5605 ggaacatcc 9 <210> 5606 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5606 Gly Thr Ser 1 <210> 5607 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5607 cagcaatttg gtgactcatt cact 24 <210> 5608 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5608 Gln Gln Phe Gly Asp Ser Phe Thr 1 5 <210> 5609 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5609 gaggtgcagc tggtggagtc tgggggaggc ttgatacagc ctgggggggc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agagatgtct tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcactt attagtggta gtggtgataa catatattat 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcagatga atagcctgag agccgaggac acggccatat attattgtgc gatagttggg 300 aactatggtg acttcgccag gtggttcgac ccctggggcc agggaaccat ggtcaccgtc 360 tcctca 366 <210> 5610 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5610 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asp 20 25 30 Val Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Gly Ser Gly Asp Asn Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Ile Val Gly Asn Tyr Gly Asp Phe Ala Arg Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5611 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5611 ggattcacct ttagcagaga tgtc 24 <210> 5612 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5612 Gly Phe Thr Phe Ser Arg Asp Val 1 5 <210> 5613 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5613 attagtggta gtggtgataa cata 24 <210> 5614 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5614 Ile Ser Gly Ser Gly Asp Asn Ile 1 5 <210> 5615 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5615 gcgatagttg ggaactatgg tgacttcgcc aggtggttcg acccc 45 <210> 5616 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5616 Ala Ile Val Gly Asn Tyr Gly Asp Phe Ala Arg Trp Phe Asp Pro 1 5 10 15 <210> 5617 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5617 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcggaaacca 120 gggaaagccc cgaacctcct gatctatgct gcatccattt tgcaaaatgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttactt ctgtcaacag agttacacta ccccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5618 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5618 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Thr Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5619 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5619 cagagcatta gcagctat 18 <210> 5620 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5620 Gln Ser Ile Ser Ser Tyr 1 5 <210> 5621 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5621 gctgcatcc 9 <210> 5622 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5622 Ala Ala Ser 1 <210> 5623 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5623 caacagagtt acactacccc gctcact 27 <210> 5624 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5624 Gln Gln Ser Tyr Thr Thr Pro Leu Thr 1 5 <210> 5625 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5625 caggtgcagc tggtggagtc tggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcagt acttactatt ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aagctgaact ctgtgaccgc cgcggacacg tctgtatatt actgtgcgag aggccctagt 300 acattaacta cagactacta cggtttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5626 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5626 Gln Val Gln Leu Val Glu Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ser Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Ser Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5627 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5627 ggtgggtcct tcagtactta ctat 24 <210> 5628 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5628 Gly Gly Ser Phe Ser Thr Tyr Tyr 1 5 <210> 5629 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5629 atcaatcata ctggaagcac c 21 <210> 5630 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5630 Ile Asn His Thr Gly Ser Thr 1 5 <210> 5631 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5631 gcgagaggcc ctagtacatt aactacagac tactacggtt tggacgtc 48 <210> 5632 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5632 Ala Arg Gly Pro Ser Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 5633 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5633 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtattagc agcagctact tagcctggta ccagcaaaaa 120 cctggccagg ctcccaggct cctcatctat gatgcatcca gcaggtccac tgacatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcactgta ttactgtcag cagtatggtg gctcaccatt cactttcggc 300 cctgggacca aggtggagat caaacga 327 <210> 5634 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5634 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Ser Arg Ser Thr Asp Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5635 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5635 cagagtatta gcagcagcta c 21 <210> 5636 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5636 Gln Ser Ile Ser Ser Ser Tyr 1 5 <210> 5637 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5637 gatgcatcc 9 <210> 5638 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5638 Asp Ala Ser 1 <210> 5639 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5639 cagcagtatg gtggctcacc attcact 27 <210> 5640 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5640 Gln Gln Tyr Gly Gly Ser Pro Phe Thr 1 5 <210> 5641 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5641 caggtgcagc tggtgcagtg gggcgcagga ctgttgatgc cttcggagac cctgtccctc 60 acctgcgctg tctctggtgg gtccttcagt tattactact ggacctggat ccgccagccc 120 ccagggaagg gtctggagtg gattggggag atcaatcata gtggaagcac caactacaac 180 ccgtccctca agagtcgaat caccatatca gtagacacgt ccaagaacca gttctccctg 240 aaactgaact ctgtgaccgc cgcggacacg gctgtgtatt attgtgcgag aggacagata 300 acagcagctg tctctgattc ttttgatgtc tggggccaag ggacaatggt caccgtctcc 360 tca 363 <210> 5642 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5642 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Met Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Phe Ser Tyr Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Gln Ile Thr Ala Ala Val Ser Asp Ser Phe Asp Val Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5643 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5643 ggtgggtcct tcagttatta ctac 24 <210> 5644 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5644 Gly Gly Ser Phe Ser Tyr Tyr Tyr 1 5 <210> 5645 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5645 atcaatcata gtggaagcac c 21 <210> 5646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5646 Ile Asn His Ser Gly Ser Thr 1 5 <210> 5647 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5647 gcgagaggac agataacagc agctgtctct gattcttttg atgtc 45 <210> 5648 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5648 Ala Arg Gly Gln Ile Thr Ala Ala Val Ser Asp Ser Phe Asp Val 1 5 10 15 <210> 5649 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5649 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagtcacc 60 ctctcctgta gggccagtca gtttgttagc agcagctatt cagcctggta ccagcagaga 120 cctggccagc ctcccagact cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttattgtcaa cagtatggta gcgcattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5650 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5650 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Phe Val Ser Ser Ser 20 25 30 Tyr Ser Ala Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5651 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5651 cagtttgtta gcagcagcta t 21 <210> 5652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5652 Gln Phe Val Ser Ser Ser Tyr 1 5 <210> 5653 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5653 ggtgcatcc 9 <210> 5654 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5654 Gly Ala Ser 1 <210> 5655 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5655 caacagtatg gtagcgcatt catt 24 <210> 5656 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5656 Gln Gln Tyr Gly Ser Ala Phe Ile 1 5 <210> 5657 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5657 caggtgcagc tggtggagtc tgggggaggc gtggtgcggc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgcca tgagctgggt ccgccaagtt 120 ccagggaagg ggctggagtg ggtctctggt attaattgga atggtgatag tagaggttat 180 gcagactctg tgaggggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agccgaggac acggccttgt attattgtgc gagagatagg 300 gatggaggtc ctccttccta ttactattat gggatggacg tctggggcca agggaccacg 360 gtcaccgtct cctca 375 <210> 5658 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5658 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Asp Ser Arg Gly Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Tyr Tyr Tyr Tyr Gly Met 100 105 110 Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5659 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5659 ggattcacct ttgatgatta tgcc 24 <210> 5660 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5660 Gly Phe Thr Phe Asp Asp Tyr Ala 1 5 <210> 5661 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5661 attaattgga atggtgatag taga 24 <210> 5662 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5662 Ile Asn Trp Asn Gly Asp Ser Arg 1 5 <210> 5663 <211> 54 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5663 gcgagagata gggatggagg tcctccttcc tattactatt atgggatgga cgtc 54 <210> 5664 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5664 Ala Arg Asp Arg Asp Gly Gly Pro Pro Ser Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 5665 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5665 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gaatattaac gactatttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagtag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgtagcaatc ggccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 5666 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5666 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asp Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Arg Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5667 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5667 cagaatatta acgactat 18 <210> 5668 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5668 Gln Asn Ile Asn Asp Tyr 1 5 <210> 5669 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5669 gatgcatcc 9 <210> 5670 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5670 Asp Ala Ser 1 <210> 5671 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5671 cagcagcgta gcaatcggcc gctcact 27 <210> 5672 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5672 Gln Gln Arg Ser Asn Arg Pro Leu Thr 1 5 <210> 5673 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5673 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgtgctg tctatggtgg gtccttcagt tcttcctact ggaactggat ccgccagccc 120 ccagggaggg gactggagtg gattggggaa atctttcata gtggaaacac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca cttctccctg 240 aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggaaagata 300 gaatcggctg tttctgattc ttttgatatc tggggccaag ggacaatggt caccgtctcc 360 tca 363 <210> 5674 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5674 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Ser 20 25 30 Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Phe His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Lys Ile Glu Ser Ala Val Ser Asp Ser Phe Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5675 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5675 ggtgggtcct tcagttcttc ctac 24 <210> 5676 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5676 Gly Gly Ser Phe Ser Ser Ser Tyr 1 5 <210> 5677 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5677 atctttcata gtggaaacac c 21 <210> 5678 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5678 Ile Phe His Ser Gly Asn Thr 1 5 <210> 5679 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5679 gcgagaggaa agatagaatc ggctgtttct gattcttttg atatc 45 <210> 5680 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5680 Ala Arg Gly Lys Ile Glu Ser Ala Val Ser Asp Ser Phe Asp Ile 1 5 10 15 <210> 5681 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5681 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagact ttgcagtgta tttctgtcag cagtatggta gctcattcat tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5682 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5682 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Phe 85 90 95 Ile Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5683 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5683 cagagtgtta gcagcagcta c 21 <210> 5684 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5684 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 5685 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5685 ggtacatcc 9 <210> 5686 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5686 Gly Thr Ser 1 <210> 5687 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5687 cagcagtatg gtagctcatt catt 24 <210> 5688 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5688 Gln Gln Tyr Gly Ser Ser Phe Ile 1 5 <210> 5689 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5689 caggtgcagc tggtggagtc tgggggaggc atggtacagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agttatgcca tgacctgggt ccgccaggct 120 ccaggaaagg ggctggagtg ggtctcagct attagtagta gtggtggtag ttcatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacactttat 240 ctgcaaatga acagtctgag agccgaggac acggccgtat attactgtgc gaaagatctg 300 ggggccctcg gctactacta cggtattgac gtctggggcc aagggaccat ggtcaccgtc 360 tcctca 366 <210> 5690 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5690 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Ser Gly Gly Ser Ser Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Leu Gly Ala Leu Gly Tyr Tyr Tyr Gly Ile Asp Val Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5691 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5691 ggattcacct ttagcagtta tgcc 24 <210> 5692 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5692 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 5693 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5693 attagtagta gtggtggtag ttca 24 <210> 5694 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5694 Ile Ser Ser Ser Gly Gly Ser Ser 1 5 <210> 5695 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5695 gcgaaagatc tgggggccct cggctactac tacggtattg acgtc 45 <210> 5696 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5696 Ala Lys Asp Leu Gly Ala Leu Gly Tyr Tyr Tyr Gly Ile Asp Val 1 5 10 15 <210> 5697 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5697 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc aactacttag cctggtacca acagagacct 120 ggccaggctc ccaggctcct catctataat gcatccaaca ggtcccctgg catccaagcc 180 aggttcagtg gcagtggttc tggaacagac ttcactctca ccatcagcag actggaacct 240 gaagattttg cagtttattc ctgtcagcag cgtagcaact ggccgtggac attcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5698 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5698 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asn Ala Ser Asn Arg Ser Pro Gly Ile Gln Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Arg Ser Asn Trp Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5699 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5699 cagagtgtta gcaactac 18 <210> 5700 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5700 Gln Ser Val Ser Asn Tyr 1 5 <210> 5701 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5701 aatgcatcc 9 <210> 5702 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5702 Asn Ala Ser 1 <210> 5703 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5703 cagcagcgta gcaactggcc gtggaca 27 <210> 5704 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5704 Gln Gln Arg Ser Asn Trp Pro Trp Thr 1 5 <210> 5705 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5705 caggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgacctgggt ccgtcaggct 120 ccagggaagg ggctggagtg ggtctcaagt attagtagta gtggtgttag cacatattac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaactga gcagcctgag agccgaggac acggccatat attactgtgc caaaggcagc 300 agctggtact actttgaatc ctggggccag ggaaccatgg tcaccgtctc ctca 354 <210> 5706 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5706 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Ser Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Glu Ser Trp Gly Gln Gly Thr 100 105 110 Met Val Thr Val Ser Ser 115 <210> 5707 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5707 ggattcacct ttagcagcta tgcc 24 <210> 5708 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5708 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 5709 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5709 attagtagta gtggtgttag caca 24 <210> 5710 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5710 Ile Ser Ser Ser Gly Val Ser Thr 1 5 <210> 5711 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5711 gccaaaggca gcagctggta ctactttgaa tcc 33 <210> 5712 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5712 Ala Lys Gly Ser Ser Trp Tyr Tyr Phe Glu Ser 1 5 10 <210> 5713 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5713 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga gagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcaaaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag aagactggag 240 cctgaagatt ttgcagtgta tttctgtcag cagtatggta gctcaccgat caccttcggc 300 caagggacac gactggagat caaacga 327 <210> 5714 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5714 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 5715 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5715 cagagtgtta gcagcagcta c 21 <210> 5716 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5716 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 5717 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5717 ggtgcatcc 9 <210> 5718 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5718 Gly Ala Ser 1 <210> 5719 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5719 cagcagtatg gtagctcacc gatcacc 27 <210> 5720 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5720 Gln Gln Tyr Gly Ser Ser Pro Ile Thr 1 5 <210> 5721 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5721 gaggtgcagc tggtggagtc tgggggaggc atggtaaagc ctggggggtc ccttagactc 60 tcctgtgcag cctctggatt tactttcaga aacgcctgga tgagctgggt ccgccaggct 120 ccagggaggg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca 180 gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacaca 240 ctatatctgc aaatgaacag cctgaaaacc gaggacatag ccatgtatta ctgtaccact 300 tataaatgga acttctttgg taactggtcc ttcgatatct ggggccatgg caccctggtc 360 accgtctcct ca 372 <210> 5722 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5722 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Ile Ala Met Tyr 85 90 95 Tyr Cys Thr Thr Tyr Lys Trp Asn Phe Phe Gly Asn Trp Ser Phe Asp 100 105 110 Ile Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5723 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5723 ggatttactt tcagaaacgc ctgg 24 <210> 5724 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5724 Gly Phe Thr Phe Arg Asn Ala Trp 1 5 <210> 5725 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5725 attaaaagca aaactgatgg tgggacaaca 30 <210> 5726 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5726 Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr 1 5 10 <210> 5727 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5727 accacttata aatggaactt ctttggtaac tggtccttcg atatc 45 <210> 5728 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5728 Thr Thr Tyr Lys Trp Asn Phe Phe Gly Asn Trp Ser Phe Asp Ile 1 5 10 15 <210> 5729 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5729 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttagaga cagagtcacc 60 atcacttgcc gggcaagtca gagtattagc agatatttaa attggtatca acagaaacca 120 gggaaagccc cgaacctcct gatctatgct gcatccagtt tggaacgtgg ggtcccatca 180 aggttcagtg ccagtggatc tgggacagat ttcactctca ccatcagcag tccgcaacct 240 gaagattatg gaacttacta ctgtcaacag agtttcagta gtccgatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 5730 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5730 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Ala 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Pro Gln Pro 65 70 75 80 Glu Asp Tyr Gly Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Ser Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 5731 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5731 cagagtatta gcagatat 18 <210> 5732 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5732 Gln Ser Ile Ser Arg Tyr 1 5 <210> 5733 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5733 gctgcatcc 9 <210> 5734 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5734 Ala Ala Ser 1 <210> 5735 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5735 caacagagtt tcagtagtcc gatcacc 27 <210> 5736 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5736 Gln Gln Ser Phe Ser Ser Pro Ile Thr 1 5 <210> 5737 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5737 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtag gtccttcagt tattactatt ggacctggat ccgccagccc 120 ccagggaagg gactggagtg gattggggaa atcaatcata ctggaagcac caactgcaac 180 ccgtccctca agagtcgagt caccctatca gtagacacgt ccaagaacca gttctccctg 240 aacctgaact ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgcg aggcccctat 300 tcagtaacta cggactacta cggcttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5738 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5738 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Arg Ser Phe Ser Tyr Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Cys Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Leu Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Tyr Ser Val Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5739 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5739 ggtaggtcct tcagttatta ctat 24 <210> 5740 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5740 Gly Arg Ser Phe Ser Tyr Tyr Tyr 1 5 <210> 5741 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5741 atcaatcata ctggaagcac c 21 <210> 5742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5742 Ile Asn His Thr Gly Ser Thr 1 5 <210> 5743 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5743 gcgcgaggcc cctattcagt aactacggac tactacggct tggacgtc 48 <210> 5744 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5744 Ala Arg Gly Pro Tyr Ser Val Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 5745 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5745 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagtcacc 60 ctctcctgca ggaccagtca gagtgttacc aacaactact tggcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat gatacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgacgatt ttgcagtgta ttactgtcag cagtttgctt acttaccgtc cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 5746 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5746 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Arg Thr Ser Gln Ser Val Thr Asn Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Ala Tyr Leu Pro 85 90 95 Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5747 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5747 cagagtgtta ccaacaacta c 21 <210> 5748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5748 Gln Ser Val Thr Asn Asn Tyr 1 5 <210> 5749 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5749 gatacatcc 9 <210> 5750 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5750 Asp Thr Ser 1 <210> 5751 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5751 cagcagtttg cttacttacc gtccact 27 <210> 5752 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5752 Gln Gln Phe Ala Tyr Leu Pro Ser Thr 1 5 <210> 5753 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5753 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcaat atttactact ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata ctggtagcac caactaccac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaggaacca gttctccctg 240 aacctgagct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag aggcccctat 300 acagtaacta cggactacta cggtatggac gtctggggcc gagggaccac ggtcaccgtc 360 tcctca 366 <210> 5754 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5754 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Ile Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Tyr Thr Val Thr Thr Asp Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Arg Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5755 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5755 ggtgggtcct tcaatattta ctac 24 <210> 5756 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5756 Gly Gly Ser Phe Asn Ile Tyr Tyr 1 5 <210> 5757 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5757 atcaatcata ctggtagcac c 21 <210> 5758 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5758 Ile Asn His Thr Gly Ser Thr 1 5 <210> 5759 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5759 gcgagaggcc cctatacagt aactacggac tactacggta tggacgtc 48 <210> 5760 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5760 Ala Arg Gly Pro Tyr Thr Val Thr Thr Asp Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 5761 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5761 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccaccagaaa 120 cctggccagg ctcccagtct cctcatctat gatacatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc 300 ggagggacca aggtggagat caaacga 327 <210> 5762 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5762 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr His Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 35 40 45 Ile Tyr Asp Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5763 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5763 cagagtgtta gcagcagcta c 21 <210> 5764 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5764 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 5765 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5765 gatacatcc 9 <210> 5766 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5766 Asp Thr Ser 1 <210> 5767 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5767 cagcagtatg gtagctcacc gctcact 27 <210> 5768 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5768 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 5769 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5769 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgttg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240 aacctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggcccattt 300 tacgatattt tgactggtta ttcccttgac tactggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 5770 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5770 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Val Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Ser Leu Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5771 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5771 ggtgggtcct tcagtggtta ctac 24 <210> 5772 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5772 Gly Gly Ser Phe Ser Gly Tyr Tyr 1 5 <210> 5773 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5773 atcaatcata gtggaagcac c 21 <210> 5774 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5774 Ile Asn His Ser Gly Ser Thr 1 5 <210> 5775 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5775 gcgagaggcc cattttacga tattttgact ggttattccc ttgactac 48 <210> 5776 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5776 Ala Arg Gly Pro Phe Tyr Asp Ile Leu Thr Gly Tyr Ser Leu Asp Tyr 1 5 10 15 <210> 5777 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5777 gacatcgtga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agctacttaa cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 5778 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5778 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 5779 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5779 cagagtgtta gcagctac 18 <210> 5780 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5780 Gln Ser Val Ser Ser Tyr 1 5 <210> 5781 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5781 gatgcatcc 9 <210> 5782 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5782 Asp Ala Ser 1 <210> 5783 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5783 cagcagcgta gcaactggcc tatcacc 27 <210> 5784 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5784 Gln Gln Arg Ser Asn Trp Pro Ile Thr 1 5 <210> 5785 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5785 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtacag cctctggatt cacctttgat gattttgcca tgcactgggt ccggcaaggt 120 ccagggaagg gcctggagtg ggtctcaggt attaattgga atagtggtag tataggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgttt 240 ctgcaaatga acagtctgag acctgaggac acggccttct attactgtgc aaaagatatt 300 gcagcagccg ggttctccta ctactacggt atggacgtct ggggccaagg gaccatggtc 360 accgtctcct ca 372 <210> 5786 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5786 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Phe 20 25 30 Ala Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Phe Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Ala Ala Ala Gly Phe Ser Tyr Tyr Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5787 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5787 ggattcacct ttgatgattt tgcc 24 <210> 5788 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5788 Gly Phe Thr Phe Asp Asp Phe Ala 1 5 <210> 5789 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5789 attaattgga atagtggtag tata 24 <210> 5790 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5790 Ile Asn Trp Asn Ser Gly Ser Ile 1 5 <210> 5791 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5791 gcaaaagata ttgcagcagc cgggttctcc tactactacg gtatggacgt c 51 <210> 5792 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5792 Ala Lys Asp Ile Ala Ala Ala Gly Phe Ser Tyr Tyr Tyr Gly Met Asp 1 5 10 15 Val <210> 5793 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5793 gacatcctga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtt gggccagtca gggcattaat aattatttag tctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacag cataatagtt acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5794 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5794 Asp Ile Leu Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Asn Asn Tyr 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5795 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5795 cagggcatta ataattat 18 <210> 5796 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5796 Gln Gly Ile Asn Asn Tyr 1 5 <210> 5797 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5797 gctgcatcc 9 <210> 5798 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5798 Ala Ala Ser 1 <210> 5799 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5799 ctacagcata atagttaccc attcact 27 <210> 5800 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5800 Leu Gln His Asn Ser Tyr Pro Phe Thr 1 5 <210> 5801 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5801 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cctcggagac cctgtccctc 60 acctgcggtg tctatggtgg gtccttcaat tattactact ggagttggat ccgccagccc 120 ccagggaagg gactggagtg gattggggaa atcaatcata ctggaagcac caactacaac 180 ccgtccctca agagtcgagt caccatagaa gtagacacgt ccaagaacca gttctccctg 240 aggttgaact ctgtgaccgc cgcggacacg gctgtatatt actgtgcgag aggcccctat 300 acagtgacta cggactacta cggtttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5802 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5802 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Gly Ser Phe Asn Tyr Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Glu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Tyr Thr Val Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5803 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5803 ggtgggtcct tcaattatta ctac 24 <210> 5804 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5804 Gly Gly Ser Phe Asn Tyr Tyr Tyr 1 5 <210> 5805 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5805 atcaatcata ctggaagcac c 21 <210> 5806 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5806 Ile Asn His Thr Gly Ser Thr 1 5 <210> 5807 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5807 gcgagaggcc cctatacagt gactacggac tactacggtt tggacgtc 48 <210> 5808 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5808 Ala Arg Gly Pro Tyr Thr Val Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 5809 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5809 gacatcgtga tgacccagtc tccaggcacc ctgtccttgt cgccagggga aagagtcacc 60 ctctcctgca gggccagtca gagtgttagt agcaggtact tagcctggta ccggcagaaa 120 cctggccagg ctcccaggct cctcatctat gacacatcca tcagggccac cggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtttggtg gttcaccgca cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 5810 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5810 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Arg 20 25 30 Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Thr Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Gly Ser Pro 85 90 95 His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5811 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5811 cagagtgtta gtagcaggta c 21 <210> 5812 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5812 Gln Ser Val Ser Ser Arg Tyr 1 5 <210> 5813 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5813 gacacatcc 9 <210> 5814 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5814 Asp Thr Ser 1 <210> 5815 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5815 cagcagtttg gtggttcacc gcacact 27 <210> 5816 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5816 Gln Gln Phe Gly Gly Ser Pro His Thr 1 5 <210> 5817 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5817 gaggtgcagc tggtggagtc tggggctgcg gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg tttccggata caccctcact gaattgtcca tacactgggt gcgacaggct 120 cctggaaaag ggcttgagtg gatgggaagt tttgatcctg aagatggtga aacaatctac 180 gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacaacctac 240 atggaactga acagcctcag aactgaggac acggccgtat attactgtgc aacagcccaa 300 cgtggatatg ttggctacgg gacatcttac tactacttct actctatgga cgtctggggc 360 caagggacca tggtcaccgt ctcctca 387 <210> 5818 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5818 Glu Val Gln Leu Val Glu Ser Gly Ala Ala Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ser Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Thr Tyr 65 70 75 80 Met Glu Leu Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ala Gln Arg Gly Tyr Val Gly Tyr Gly Thr Ser Tyr Tyr Tyr 100 105 110 Phe Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 5819 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5819 ggatacaccc tcactgaatt gtcc 24 <210> 5820 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5820 Gly Tyr Thr Leu Thr Glu Leu Ser 1 5 <210> 5821 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5821 tttgatcctg aagatggtga aaca 24 <210> 5822 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5822 Phe Asp Pro Glu Asp Gly Glu Thr 1 5 <210> 5823 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5823 gcaacagccc aacgtggata tgttggctac gggacatctt actactactt ctactctatg 60 gacgtc 66 <210> 5824 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5824 Ala Thr Ala Gln Arg Gly Tyr Val Gly Tyr Gly Thr Ser Tyr Tyr Tyr 1 5 10 15 Phe Tyr Ser Met Asp Val 20 <210> 5825 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5825 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcaatggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5826 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5826 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Asn Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5827 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5827 cagggcatta gaaatgat 18 <210> 5828 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5828 Gln Gly Ile Arg Asn Asp 1 5 <210> 5829 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5829 gctgcatcc 9 <210> 5830 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5830 Ala Ala Ser 1 <210> 5831 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5831 ctacaagatt acaattaccc gtggacg 27 <210> 5832 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5832 Leu Gln Asp Tyr Asn Tyr Pro Trp Thr 1 5 <210> 5833 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5833 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg gttggcagtt atatggtttg atggaagtaa taaatactat 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagagata 300 gcagctcgtc cttttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 5834 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5834 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 35 40 45 Ala Val Ile Trp Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Ala Arg Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 5835 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5835 ggattcacct tcagtagcta tggc 24 <210> 5836 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5836 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 5837 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5837 atatggtttg atggaagtaa taaa 24 <210> 5838 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5838 Ile Trp Phe Asp Gly Ser Asn Lys 1 5 <210> 5839 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5839 gcgagagaga tagcagctcg tccttttgac tac 33 <210> 5840 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5840 Ala Arg Glu Ile Ala Ala Arg Pro Phe Asp Tyr 1 5 10 <210> 5841 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5841 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaagctccc 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 5842 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5842 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 5843 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5843 cagagcctcc tgcatagtaa tggatacaac tat 33 <210> 5844 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5844 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 5845 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5845 ttgggttct 9 <210> 5846 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5846 Leu Gly Ser 1 <210> 5847 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5847 atgcaagctc tacaagctcc ctacact 27 <210> 5848 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5848 Met Gln Ala Leu Gln Ala Pro Tyr Thr 1 5 <210> 5849 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5849 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgttg tctctggtgg gtccttccgt ctttactact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata ctgggagcaa caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca cttctccctg 240 aagctgaatt ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggcccctat 300 tcagtgacta cggactacta cggtttggac gtctggggcc aagggaccat ggtcaccgtc 360 tcctca 366 <210> 5850 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5850 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Phe Arg Leu Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Tyr Ser Val Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 5851 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5851 ggtgggtcct tccgtcttta ctac 24 <210> 5852 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5852 Gly Gly Ser Phe Arg Leu Tyr Tyr 1 5 <210> 5853 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5853 atcaatcata ctgggagcaa c 21 <210> 5854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5854 Ile Asn His Thr Gly Ser Asn 1 5 <210> 5855 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5855 gcgagaggcc cctattcagt gactacggac tactacggtt tggacgtc 48 <210> 5856 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5856 Ala Arg Gly Pro Tyr Ser Val Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 5857 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5857 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccggggga aagagccacc 60 ctctcctgca gggccagtca gagttttaac agcgactact tagcctggta ccagcagaaa 120 cctggccaga ctcccaggct cctcatctat ggtacgtcca ccagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag gagactggag 240 cctgaagatt ttgcagtgta ttactgtcac cagtatggta gtttgccgct cacattcggc 300 ggagggacca aggtggagat caaacga 327 <210> 5858 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5858 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Phe Asn Ser Asp 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Leu Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5859 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5859 cagagtttta acagcgacta c 21 <210> 5860 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5860 Gln Ser Phe Asn Ser Asp Tyr 1 5 <210> 5861 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5861 ggtacgtcc 9 <210> 5862 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5862 Gly Thr Ser 1 <210> 5863 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5863 caccagtatg gtagtttgcc gctcaca 27 <210> 5864 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5864 His Gln Tyr Gly Ser Leu Pro Leu Thr 1 5 <210> 5865 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5865 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggccggagtg ggtggcactt atttggtatg atggaattaa taaatatcat 180 ggagagtccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agtcgaggac acggctgtgt attactgtgc gagagatcgg 300 gacgtgtttc gcagttcgta tcactcctat tacggtatgg atgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 5866 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5866 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45 Ala Leu Ile Trp Tyr Asp Gly Ile Asn Lys Tyr His Gly Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Asp Val Phe Arg Ser Ser Tyr His Ser Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5867 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5867 ggattcacct tcagtaccta tggc 24 <210> 5868 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5868 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 5869 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5869 atttggtatg atggaattaa taaa 24 <210> 5870 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5870 Ile Trp Tyr Asp Gly Ile Asn Lys 1 5 <210> 5871 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5871 gcgagagatc gggacgtgtt tcgcagttcg tatcactcct attacggtat ggatgtc 57 <210> 5872 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5872 Ala Arg Asp Arg Asp Val Phe Arg Ser Ser Tyr His Ser Tyr Tyr Gly 1 5 10 15 Met Asp Val <210> 5873 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5873 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catggtaatg gacacaacta tttggattgg 120 tacatgcaga agtcagggca gtctccacag gtcctgatct atttgggttc taagcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac attgaaaatc 240 agcagagtgg aggctgagga tgttgggatt tattactgca tgcaagctct acaaactccc 300 actttcggcg gagggaccaa ggtggagatc aaacga 336 <210> 5874 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5874 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Gly 20 25 30 Asn Gly His Asn Tyr Leu Asp Trp Tyr Met Gln Lys Ser Gly Gln Ser 35 40 45 Pro Gln Val Leu Ile Tyr Leu Gly Ser Lys Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 <210> 5875 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5875 cagagcctcc tgcatggtaa tggacacaac tat 33 <210> 5876 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5876 Gln Ser Leu Leu His Gly Asn Gly His Asn Tyr 1 5 10 <210> 5877 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5877 ttgggttct 9 <210> 5878 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5878 Leu Gly Ser 1 <210> 5879 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5879 atgcaagctc tacaaactcc cact 24 <210> 5880 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5880 Met Gln Ala Leu Gln Thr Pro Thr 1 5 <210> 5881 <211> 387 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5881 gaggtgcagc tggtggagtc tggggctgcg gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg tttccggata caccctcact gaattgtcca tacactgggt gcgacaggct 120 cctggaaaag ggcttgagtg gatgggaagt tttgatcctg aagatggtga aacaatctac 180 gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacaacctac 240 atggaactga acagcctcag aactgaggac acggccgtat attactgtgc aacagcccaa 300 cgtggatatg ttggctacgg gacatcttac tactacttct actctatgga cgtctggggc 360 caagggacca cggtcaccgt ctcctca 387 <210> 5882 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5882 Glu Val Gln Leu Val Glu Ser Gly Ala Ala Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ser Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Thr Tyr 65 70 75 80 Met Glu Leu Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ala Gln Arg Gly Tyr Val Gly Tyr Gly Thr Ser Tyr Tyr Tyr 100 105 110 Phe Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 5883 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5883 ggatacaccc tcactgaatt gtcc 24 <210> 5884 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5884 Gly Tyr Thr Leu Thr Glu Leu Ser 1 5 <210> 5885 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5885 tttgatcctg aagatggtga aaca 24 <210> 5886 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5886 Phe Asp Pro Glu Asp Gly Glu Thr 1 5 <210> 5887 <211> 66 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5887 gcaacagccc aacgtggata tgttggctac gggacatctt actactactt ctactctatg 60 gacgtc 66 <210> 5888 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5888 Ala Thr Ala Gln Arg Gly Tyr Val Gly Tyr Gly Thr Ser Tyr Tyr Tyr 1 5 10 15 Phe Tyr Ser Met Asp Val 20 <210> 5889 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5889 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcaatggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 5890 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5890 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Asn Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5891 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5891 cagggcatta gaaatgat 18 <210> 5892 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5892 Gln Gly Ile Arg Asn Asp 1 5 <210> 5893 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5893 gctgcatcc 9 <210> 5894 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5894 Ala Ala Ser 1 <210> 5895 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5895 ctacaagatt acaattaccc gtggacg 27 <210> 5896 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5896 Leu Gln Asp Tyr Asn Tyr Pro Trp Thr 1 5 <210> 5897 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5897 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gtccttcaat atttactact ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcaatcata ctggaagcac caactacatc 180 ccgtccctca agagtcgagt cagcatatca gtagacacgt ccaagaacca gttctccctt 240 aaactgacct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggcccctat 300 acactaacaa cggactatta cggtttggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 5898 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5898 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Asn Ile Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Ile Pro Ser Leu Lys 50 55 60 Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Pro Tyr Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5899 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5899 ggtgggtcct tcaatattta ctac 24 <210> 5900 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5900 Gly Gly Ser Phe Asn Ile Tyr Tyr 1 5 <210> 5901 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5901 atcaatcata ctggaagcac c 21 <210> 5902 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5902 Ile Asn His Thr Gly Ser Thr 1 5 <210> 5903 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5903 gcgagaggcc cctatacact aacaacggac tattacggtt tggacgtc 48 <210> 5904 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5904 Ala Arg Gly Pro Tyr Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 5905 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5905 gacatccaga tgacccagtc tccagacacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtattagc agcgactact tagcctggta ccaacaaaaa 120 actggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgagaca gacttcactc tcaacatcag cagactggag 240 gctgaagatt ttgcagtgta ttactgtcag cagtatggtg gctcaccgtc cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 5906 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5906 Asp Ile Gln Met Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Asp 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Thr Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Asn Ile Ser Arg Leu Glu 65 70 75 80 Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 85 90 95 Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5907 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5907 cagagtatta gcagcgacta c 21 <210> 5908 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5908 Gln Ser Ile Ser Ser Asp Tyr 1 5 <210> 5909 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5909 ggtgcatcc 9 <210> 5910 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5910 Gly Ala Ser 1 <210> 5911 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5911 cagcagtatg gtggctcacc gtccact 27 <210> 5912 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5912 Gln Gln Tyr Gly Gly Ser Pro Ser Thr 1 5 <210> 5913 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5913 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtggcg tctctggatt cacctttgat gatcatgcca tgcactgggt ccggcaagct 120 ccagggaagg gcctggagtg ggtcgcaggt attagttgga atagtggtag catgggctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctctat 240 ctgcaaatga acagtctgag acctgaagac acggccttgt attactgtgc aagagatata 300 gcagcagctg gactccatta ctacggtatg gacgtctggg gccaagggac cacggtcacc 360 gtctcctca 369 <210> 5914 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5914 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Gly Val Ser Gly Phe Thr Phe Asp Asp His 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Asp Ile Ala Ala Ala Gly Leu His Tyr Tyr Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 5915 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5915 ggattcacct ttgatgatca tgcc 24 <210> 5916 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5916 Gly Phe Thr Phe Asp Asp His Ala 1 5 <210> 5917 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5917 attagttgga atagtggtag catg 24 <210> 5918 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5918 Ile Ser Trp Asn Ser Gly Ser Met 1 5 <210> 5919 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5919 gcaagagata tagcagcagc tggactccat tactacggta tggacgtc 48 <210> 5920 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5920 Ala Arg Asp Ile Ala Ala Ala Gly Leu His Tyr Tyr Gly Met Asp Val 1 5 10 15 <210> 5921 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5921 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtagaaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagaaacca 120 gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caatttatta ctgtctacag tataatagtt acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 5922 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5922 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Glu 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Leu Gln Tyr Asn Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5923 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5923 caggacatta gaaatgat 18 <210> 5924 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5924 Gln Asp Ile Arg Asn Asp 1 5 <210> 5925 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5925 gctgcatcc 9 <210> 5926 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5926 Ala Ala Ser 1 <210> 5927 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5927 ctacagtata atagttaccc attcact 27 <210> 5928 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5928 Leu Gln Tyr Asn Ser Tyr Pro Phe Thr 1 5 <210> 5929 <211> 378 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5929 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggccggagtg ggtggcaatt atttggtatg atggaattaa taaatatcat 180 ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agtcgaggac acggctgtgt attactgtgc gagagatcgg 300 gacgtgtttc gcagttcgta ttattcctat tacggtatgg atgtctgggg ccaagggacc 360 acggtcaccg tctcctca 378 <210> 5930 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5930 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 35 40 45 Ala Ile Ile Trp Tyr Asp Gly Ile Asn Lys Tyr His Gly Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Asp Val Phe Arg Ser Ser Tyr Tyr Ser Tyr Tyr Gly 100 105 110 Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 5931 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5931 ggattcacct tcagtagcta tggc 24 <210> 5932 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5932 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 5933 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5933 atttggtatg atggaattaa taaa 24 <210> 5934 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5934 Ile Trp Tyr Asp Gly Ile Asn Lys 1 5 <210> 5935 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5935 gcgagagatc gggacgtgtt tcgcagttcg tattattcct attacggtat ggatgtc 57 <210> 5936 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5936 Ala Arg Asp Arg Asp Val Phe Arg Ser Ser Tyr Tyr Ser Tyr Tyr Gly 1 5 10 15 Met Asp Val <210> 5937 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5937 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctccta catggtaatg gacacaacta tttggattgg 120 tacatgcaga agtcagggca gtctccacag gtcctgatct atttgggttc taagcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac attgaaaatc 240 agcacagtgg aggctgagga tgttgggatt tattactgca tgcaagctct acaaactccc 300 actttcggcg gagggaccaa ggtggagatc aaacga 336 <210> 5938 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5938 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Gly 20 25 30 Asn Gly His Asn Tyr Leu Asp Trp Tyr Met Gln Lys Ser Gly Gln Ser 35 40 45 Pro Gln Val Leu Ile Tyr Leu Gly Ser Lys Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Thr Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 <210> 5939 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5939 cagagcctcc tacatggtaa tggacacaac tat 33 <210> 5940 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5940 Gln Ser Leu Leu His Gly Asn Gly His Asn Tyr 1 5 10 <210> 5941 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5941 ttgggttct 9 <210> 5942 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5942 Leu Gly Ser 1 <210> 5943 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5943 atgcaagctc tacaaactcc cact 24 <210> 5944 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5944 Met Gln Ala Leu Gln Thr Pro Thr 1 5 <210> 5945 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5945 caggtgcagc tggtgcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tcaatggtgg gtccttcagt ggttacttct ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcattcaaa gtggaaccat cacctacaac 180 ccgtccctca agagtcgagt caccatatcg atagacacgt ccactaacca gttctccctg 240 aagctgacct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcggg gaataagtgg 300 aactacgaga ggtggttcga cccctggggc cagggaacca tggtcaccgt ctcctca 357 <210> 5946 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5946 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Asn Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Ile Gln Ser Gly Thr Ile Thr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Thr Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Gly Asn Lys Trp Asn Tyr Glu Arg Trp Phe Asp Pro Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 5947 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5947 ggtgggtcct tcagtggtta cttc 24 <210> 5948 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5948 Gly Gly Ser Phe Ser Gly Tyr Phe 1 5 <210> 5949 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5949 atcattcaaa gtggaaccat c 21 <210> 5950 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5950 Ile Ile Gln Ser Gly Thr Ile 1 5 <210> 5951 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5951 gcggggaata agtggaacta cgagaggtgg ttcgacccc 39 <210> 5952 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5952 Ala Gly Asn Lys Trp Asn Tyr Glu Arg Trp Phe Asp Pro 1 5 10 <210> 5953 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5953 gacatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc 60 ctctcctgta gggccagtca gagtgttaga agcaacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt atatttacca gggccactaa tatcccagcc 180 aggttcagtg gtggtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagactttg cagtttatta ctgtcagcag tatcataact ggatcacctt cggccaaggg 300 acacgactgg agattaaacg a 321 <210> 5954 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5954 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ile Phe Thr Arg Ala Thr Asn Ile Pro Ala Arg Phe Ser Gly 50 55 60 Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Asn Trp Ile Thr 85 90 95 Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 5955 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5955 cagagtgtta gaagcaac 18 <210> 5956 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5956 Gln Ser Val Arg Ser Asn 1 5 <210> 5957 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5957 ggtatattt 9 <210> 5958 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5958 Gly Ile Phe 1 <210> 5959 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5959 cagcagtatc ataactggat cacc 24 <210> 5960 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5960 Gln Gln Tyr His Asn Trp Ile Thr 1 5 <210> 5961 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5961 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc 60 tcctgtgcag cgtctggatt caccttcagt acctatggca tgcactgggt ccgccaggct 120 ccaggcaagg gactggagtg ggtggcatct atatggtatg atggaaccaa taaaaactat 180 gtaaactccg tgtggggccg attcaccatc tccagagaca actccaagaa cacgctgtat 240 ttgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gacagaaatc 300 gcagctcgtc cctttgagta ttggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 5962 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5962 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ser Ile Trp Tyr Asp Gly Thr Asn Lys Asn Tyr Val Asn Ser Val 50 55 60 Trp Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 5963 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5963 ggattcacct tcagtaccta tggc 24 <210> 5964 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5964 Gly Phe Thr Phe Ser Thr Tyr Gly 1 5 <210> 5965 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5965 atatggtatg atggaaccaa taaa 24 <210> 5966 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5966 Ile Trp Tyr Asp Gly Thr Asn Lys 1 5 <210> 5967 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5967 gcgacagaaa tcgcagctcg tccctttgag tat 33 <210> 5968 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5968 Ala Thr Glu Ile Ala Ala Arg Pro Phe Glu Tyr 1 5 10 <210> 5969 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5969 gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttt taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt gtctcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttgggatt tattactgca tgcaagctct gcaaattccg 300 tacacttttg gccaggggac caaggtggag atcaaacga 339 <210> 5970 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5970 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Phe Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Val Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg <210> 5971 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5971 cagagcctcc tgcatagtaa tggatacaac tat 33 <210> 5972 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5972 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 1 5 10 <210> 5973 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5973 ttgggtttt 9 <210> 5974 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5974 Leu Gly Phe 1 <210> 5975 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5975 atgcaagctc tgcaaattcc gtacact 27 <210> 5976 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5976 Met Gln Ala Leu Gln Ile Pro Tyr Thr 1 5 <210> 5977 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5977 gaggtgcagc tggtggagtc tgggggaggc ttgtttcagc ctgacaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatgaca tgcactgggt ccggcaagct 120 ccagggaagg gcctggaatg ggtctcaggt attagttgga atagtgttaa caaagactgt 180 gcggactctg tgaggggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag aactgaggac acggccttct attactgtgc aaagagtgcc 300 ttaactgtgg atgccctcta ctggtatttc gatatctggg gccgtggcac cctggtcacc 360 gtctcctca 369 <210> 5978 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5978 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Phe Gln Pro Asp Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Val Asn Lys Asp Cys Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Phe Tyr Tyr Cys 85 90 95 Ala Lys Ser Ala Leu Thr Val Asp Ala Leu Tyr Trp Tyr Phe Asp Ile 100 105 110 Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 5979 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5979 ggattcacct ttgatgatta tgac 24 <210> 5980 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5980 Gly Phe Thr Phe Asp Asp Tyr Asp 1 5 <210> 5981 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5981 attagttgga atagtgttaa caaa 24 <210> 5982 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5982 Ile Ser Trp Asn Ser Val Asn Lys 1 5 <210> 5983 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5983 gcaaagagtg ccttaactgt ggatgccctc tactggtatt tcgatatc 48 <210> 5984 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5984 Ala Lys Ser Ala Leu Thr Val Asp Ala Leu Tyr Trp Tyr Phe Asp Ile 1 5 10 15 <210> 5985 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5985 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagtcacc 60 ctctcctgca gggccagtca gatttttggc agcagttact tagcctggta ccaactgaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctggag 240 cctgaagatt ttgcagtgta ttactgtcag cactatggta gctcacctta cacttttggc 300 caggggacca aggtggagat caaacga 327 <210> 5986 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5986 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ile Phe Gly Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Leu Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 5987 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5987 cagatttttg gcagcagtta c 21 <210> 5988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5988 Gln Ile Phe Gly Ser Ser Tyr 1 5 <210> 5989 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5989 ggtgcatcc 9 <210> 5990 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5990 Gly Ala Ser 1 <210> 5991 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5991 cagcactatg gtagctcacc ttacact 27 <210> 5992 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5992 Gln His Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 5993 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5993 caggtgcagc tggtggagtc tggcgcagga ctgttgaagc cttcggagac cctgtccctc 60 acctgcgctg tctatggtgg gctcttcagt ggttacttct ggagctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggaa atcattcaaa gtggaagcat cacctacaac 180 ccgtctctca agagtcgagt caccatatcg atagacacgt ccactaatca gttctccctg 240 aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcggg aaataagtgg 300 aactacgaga ggtggttcga cccctggggc cagggaaccc tggtcaccgt ctcctca 357 <210> 5994 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5994 Gln Val Gln Leu Val Glu Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Leu Phe Ser Gly Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Ile Gln Ser Gly Ser Ile Thr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Thr Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Gly Asn Lys Trp Asn Tyr Glu Arg Trp Phe Asp Pro Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 5995 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5995 ggtgggctct tcagtggtta cttc 24 <210> 5996 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5996 Gly Gly Leu Phe Ser Gly Tyr Phe 1 5 <210> 5997 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5997 atcattcaaa gtggaagcat c 21 <210> 5998 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 5998 Ile Ile Gln Ser Gly Ser Ile 1 5 <210> 5999 <211> 39 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 5999 gcgggaaata agtggaacta cgagaggtgg ttcgacccc 39 <210> 6000 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6000 Ala Gly Asn Lys Trp Asn Tyr Glu Arg Trp Phe Asp Pro 1 5 10 <210> 6001 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6001 gacattgtga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aggagccacc 60 ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc 180 aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240 gaagattttg cagtttatta ctgtcagcag tatcataact ggatcacctt cggccaaggg 300 acacgactgg agattaaacg a 321 <210> 6002 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6002 Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Asn Trp Ile Thr 85 90 95 Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 6003 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6003 cagagtgtta gcagcaac 18 <210> 6004 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6004 Gln Ser Val Ser Ser Asn 1 5 <210> 6005 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6005 ggtgcatcc 9 <210> 6006 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6006 Gly Ala Ser 1 <210> 6007 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6007 cagcagtatc ataactggat cacc 24 <210> 6008 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6008 Gln Gln Tyr His Asn Trp Ile Thr 1 5 <210> 6009 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6009 caggtgcagc tggtgcagtg gggcgcagga ctattgaagc cttcggagac cctgtccctc 60 acctccgctg tctataatgg gtccttcact atttattatt ggacctggat ccgccagccc 120 ccagggaagg ggctggagtg gattggggag atcaatcata ctggaagtac caactacaac 180 ccgtccctca agagtcgagt caccatatca gtagacacgc ccaagaacca gttctctctg 240 aaactaacct cagtgaccgc cgcggacacg gctgtttatt tctgtgcgag aggcccctat 300 acattaacta cggactacta cggtctggac gtctggggcc aagggaccac ggtcaccgtc 360 tcctca 366 <210> 6010 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6010 Gln Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Ser Ala Val Tyr Asn Gly Ser Phe Thr Ile Tyr 20 25 30 Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Pro Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Gly Pro Tyr Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6011 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6011 aatgggtcct tcactattta ttat 24 <210> 6012 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6012 Asn Gly Ser Phe Thr Ile Tyr Tyr 1 5 <210> 6013 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6013 atcaatcata ctggaagtac c 21 <210> 6014 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6014 Ile Asn His Thr Gly Ser Thr 1 5 <210> 6015 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6015 gcgagaggcc cctatacatt aactacggac tactacggtc tggacgtc 48 <210> 6016 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6016 Ala Arg Gly Pro Tyr Thr Leu Thr Thr Asp Tyr Tyr Gly Leu Asp Val 1 5 10 15 <210> 6017 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6017 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agctactact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat gatacatcca ccagggccac tggcatccca 180 gacaggttca ttggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcaa cagtttggta gttcaccgct cactttcggc 300 ggagggacca aggtggagat caaacga 327 <210> 6018 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6018 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Thr Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ile 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6019 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6019 cagagtgtta gcagctacta c 21 <210> 6020 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6020 Gln Ser Val Ser Ser Tyr Tyr 1 5 <210> 6021 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6021 gatacatcc 9 <210> 6022 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6022 Asp Thr Ser 1 <210> 6023 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6023 caacagtttg gtagttcacc gctcact 27 <210> 6024 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6024 Gln Gln Phe Gly Ser Ser Pro Leu Thr 1 5 <210> 6025 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6025 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtacag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg gatggcagat atatggtatg atggaagtaa tacagactat 180 gtagactccg tgaagggccg attcaccatc tcaagagaca attccaagaa cacgttgtat 240 ctccaaatga acagcctgag agtcgaggac acggctgttt attactgtgc gagagatcgg 300 catagtaaca gctggttaga ctacttagaa tattggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 6026 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6026 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Ala Asp Ile Trp Tyr Asp Gly Ser Asn Thr Asp Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg His Ser Asn Ser Trp Leu Asp Tyr Leu Glu Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6027 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6027 ggattcacct tcagtagcta tggc 24 <210> 6028 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6028 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 6029 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6029 atatggtatg atggaagtaa taca 24 <210> 6030 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6030 Ile Trp Tyr Asp Gly Ser Asn Thr 1 5 <210> 6031 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6031 gcgagagatc ggcatagtaa cagctggtta gactacttag aatat 45 <210> 6032 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6032 Ala Arg Asp Arg His Ser Asn Ser Trp Leu Asp Tyr Leu Glu Tyr 1 5 10 15 <210> 6033 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6033 gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca acagacacca 120 gggaaagccc ctaagcgcct gatttatgct gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa cataatagtc accctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 6034 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6034 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser His Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6035 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6035 caggacatta gaaatgat 18 <210> 6036 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6036 Gln Asp Ile Arg Asn Asp 1 5 <210> 6037 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6037 gctgcatcc 9 <210> 6038 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6038 Ala Ala Ser 1 <210> 6039 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6039 ctacaacata atagtcaccc tctcact 27 <210> 6040 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6040 Leu Gln His Asn Ser His Pro Leu Thr 1 5 <210> 6041 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6041 gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgtag cctctgggtt caccgtcact agtaactata tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagtt atttataccg gtgatacgac acactacgca 180 gactccgtga agggccgatt caccatctcc agacacaatt ccaagaatac gctgtatctt 240 caaatgaata ccctgagagc tgaggacacg gccgtgtatt actgtgcgag agatagaatt 300 acgatccgag actgtggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 6042 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6042 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Val Thr Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Thr Gly Asp Thr Thr His Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6043 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6043 gggttcaccg tcactagtaa ctat 24 <210> 6044 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6044 Gly Phe Thr Val Thr Ser Asn Tyr 1 5 <210> 6045 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6045 atttataccg gtgatacgac a 21 <210> 6046 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6046 Ile Tyr Thr Gly Asp Thr Thr 1 5 <210> 6047 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6047 gcgagagata gaattacgat ccgagactgt ggtatggacg tc 42 <210> 6048 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6048 Ala Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val 1 5 10 <210> 6049 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6049 gacatcctga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcagttgtc gggcgagtca ggatataagc agctggttag cctggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggata tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6050 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6050 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6051 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6051 caggatataa gcagctgg 18 <210> 6052 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6052 Gln Asp Ile Ser Ser Trp 1 5 <210> 6053 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6053 gttgcatcc 9 <210> 6054 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6054 Val Ala Ser 1 <210> 6055 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6055 caacaggcta acagtttccc gtggacg 27 <210> 6056 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6056 Gln Gln Ala Asn Ser Phe Pro Trp Thr 1 5 <210> 6057 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6057 gaggtgcagc tggtggagtc tggagcagag gagaaaaagc ccggggaatc tctgaagatc 60 tcctgtaagg gttctggata cagctttacc accttctgga tcggctgggt gcgccagatg 120 cccgggcaag gcctggagtg gatgggcttc gtctatcctg gtgactctga taccagatac 180 agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatat attactgtgc gagacagctg 300 cgatatatca gttcgtcggg tgcttttgat atctggggcc aagggacaat ggtcaccgtc 360 tcttca 366 <210> 6058 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6058 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Glu Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Phe 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Phe Val Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gln Leu Arg Tyr Ile Ser Ser Ser Gly Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 6059 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6059 ggatacagct ttaccacctt ctgg 24 <210> 6060 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6060 Gly Tyr Ser Phe Thr Thr Phe Trp 1 5 <210> 6061 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6061 gtctatcctg gtgactctga tacc 24 <210> 6062 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6062 Val Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 6063 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6063 gcgagacagc tgcgatatat cagttcgtcg ggtgcttttg atatc 45 <210> 6064 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6064 Ala Arg Gln Leu Arg Tyr Ile Ser Ser Ser Gly Ala Phe Asp Ile 1 5 10 15 <210> 6065 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6065 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattagt acttatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gtttccagtt tgcaaactgg ggtcccatca 180 aggttcagtg gcagtggatc tgtgacagat ttcactctca ccgtcagcag tctgcaacct 240 gaagattttg catcttacta ctgtcaacag acttacagtc ttccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 6066 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6066 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Val Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Val Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Thr Tyr Ser Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6067 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6067 cagaccatta gtacttat 18 <210> 6068 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6068 Gln Thr Ile Ser Thr Tyr 1 5 <210> 6069 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6069 ggtgtttcc 9 <210> 6070 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6070 Gly Val Ser 1 <210> 6071 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6071 caacagactt acagtcttcc gctcact 27 <210> 6072 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6072 Gln Gln Thr Tyr Ser Leu Pro Leu Thr 1 5 <210> 6073 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6073 gaggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60 tcctgtaagg gttctggata cacctttacc aactactggc tcggctgggt gcgccagatg 120 cccgggaaag gcctggaatg gatgggattc atccatcctt ctgactctga taccagatac 180 agtccgtcct tccaaggcct ggtcaccatg tcagccgaca agtccatcac caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacagctg 300 cgttatatta cctcgtcggg cgcttttgat atctggggcc aagggacaat ggtcaccgtc 360 tcttca 366 <210> 6074 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6074 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile His Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Leu Val Thr Met Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gln Leu Arg Tyr Ile Thr Ser Ser Gly Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 6075 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6075 ggatacacct ttaccaacta ctgg 24 <210> 6076 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6076 Gly Tyr Thr Phe Thr Asn Tyr Trp 1 5 <210> 6077 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6077 atccatcctt ctgactctga tacc 24 <210> 6078 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6078 Ile His Pro Ser Asp Ser Asp Thr 1 5 <210> 6079 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6079 gcgagacagc tgcgttatat tacctcgtcg ggcgcttttg atatc 45 <210> 6080 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6080 Ala Arg Gln Leu Arg Tyr Ile Thr Ser Ser Gly Ala Phe Asp Ile 1 5 10 15 <210> 6081 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6081 gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gataattagc agctatttaa attggtatca gcaaaaccca 120 gggaaggccc ctaaactcct gatctatgct atatccactt tggaaagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactttca ccatcagcac tctgcaacct 240 gaagattttg caacttacta ctgtcagcag acttacagtc tcccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 6082 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6082 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Asn Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ile Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6083 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6083 cagataatta gcagctat 18 <210> 6084 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6084 Gln Ile Ile Ser Ser Tyr 1 5 <210> 6085 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6085 gctatatcc 9 <210> 6086 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6086 Ala Ile Ser 1 <210> 6087 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6087 cagcagactt acagtctccc gctcact 27 <210> 6088 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6088 Gln Gln Thr Tyr Ser Leu Pro Leu Thr 1 5 <210> 6089 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6089 gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctgggtt caccgtcagt aacaattata tgacctgggt ccgccaggct 120 ccagggaagg ggctggaatg ggtctcagtt atttataccg gtgagaccac acactacgca 180 gactccgtga tgggccgatt caccatctcc agagacattt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagaac tgaggacacg gccgtgtatt attgtgcgag agatagaatc 300 acgatccgag actgcggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 6090 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6090 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Thr Gly Glu Thr Thr His Tyr Ala Asp Ser Val Met 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6091 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6091 gggttcaccg tcagtaacaa ttat 24 <210> 6092 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6092 Gly Phe Thr Val Ser Asn Asn Tyr 1 5 <210> 6093 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6093 atttataccg gtgagaccac a 21 <210> 6094 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6094 Ile Tyr Thr Gly Glu Thr Thr 1 5 <210> 6095 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6095 gcgagagata gaatcacgat ccgagactgc ggtatggacg tc 42 <210> 6096 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6096 Ala Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val 1 5 10 <210> 6097 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6097 gacatcctga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagaatcacc 60 atcacttgtc gggcgagtca ggatattagc agctggttag cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatatt gcttccagtt tgcaaagtgg ggtcccagca 180 agattcagcg gcagtggatc tgagacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6098 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6098 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ile Ala Ser Ser Leu Gln Ser Gly Val Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6099 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6099 caggatatta gcagctgg 18 <210> 6100 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6100 Gln Asp Ile Ser Ser Trp 1 5 <210> 6101 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6101 attgcttcc 9 <210> 6102 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6102 Ile Ala Ser 1 <210> 6103 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6103 caacaggcta acagtttccc gtggacg 27 <210> 6104 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6104 Gln Gln Ala Asn Ser Phe Pro Trp Thr 1 5 <210> 6105 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6105 gaggtgcagc tggtggagtc tggagcagaa atgagaaagc ccggggagtc tctgaggatt 60 tcctgtaagg attctggata caggttaacc aacaactgga tcggctgggt gcgccaaatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgccagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac 240 ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacaagcc 300 ggtataagta gaagtatgtg ctttgactcc tggggccagg gaaccatggt caccgtctcc 360 tca 363 <210> 6106 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6106 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Met Arg Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Asp Ser Gly Tyr Arg Leu Thr Asn Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ala Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gln Ala Gly Ile Ser Arg Ser Met Cys Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 6107 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6107 ggatacaggt taaccaacaa ctgg 24 <210> 6108 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6108 Gly Tyr Arg Leu Thr Asn Asn Trp 1 5 <210> 6109 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6109 atctatcctg gtgactctga tgcc 24 <210> 6110 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6110 Ile Tyr Pro Gly Asp Ser Asp Ala 1 5 <210> 6111 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6111 gcgagacaag ccggtataag tagaagtatg tgctttgact cc 42 <210> 6112 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6112 Ala Arg Gln Ala Gly Ile Ser Arg Ser Met Cys Phe Asp Ser 1 5 10 <210> 6113 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6113 gacatcgtga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc 60 gtcacttgcc gggcaagtca gagaattaac agttatttaa attggtatca gcaaagacca 120 gggatagtcc ctaagatcct gatctatttt gcatccagtt tgcagagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caatttatta ttgtcaacag agttacattc tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 6114 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6114 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Arg Ile Asn Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Arg Pro Gly Ile Val Pro Lys Ile Leu Ile 35 40 45 Tyr Phe Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ile Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6115 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6115 cagagaatta acagttat 18 <210> 6116 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6116 Gln Arg Ile Asn Ser Tyr 1 5 <210> 6117 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6117 tttgcatcc 9 <210> 6118 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6118 Phe Ala Ser 1 <210> 6119 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6119 caacagagtt acattctccc gtacact 27 <210> 6120 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6120 Gln Gln Ser Tyr Ile Leu Pro Tyr Thr 1 5 <210> 6121 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6121 caggtgcagc tggtggagtc tggaggaggc ttggtccaac ctggggggtc cctgagactc 60 tcctgtgcag cctctgggtt ctccgtcaat agcaattaca tgacctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagtt atctataccg gtgataccac acactacgca 180 gactccgtga agggccgatt caccatctcc agagacactt ccaagaacac cctgtttctt 240 caaatgaaca gcctgagatc tgaggacacg gccgtttatt actgtgcgag agacagaatc 300 acgatccgag attgcggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 6122 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6122 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Asn Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Thr Gly Asp Thr Thr His Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Phe Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6123 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6123 gggttctccg tcaatagcaa ttac 24 <210> 6124 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6124 Gly Phe Ser Val Asn Ser Asn Tyr 1 5 <210> 6125 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6125 atctataccg gtgataccac a 21 <210> 6126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6126 Ile Tyr Thr Gly Asp Thr Thr 1 5 <210> 6127 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6127 gcgagagaca gaatcacgat ccgagattgc ggtatggacg tc 42 <210> 6128 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6128 Ala Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val 1 5 10 <210> 6129 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6129 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca ggatattagc agctggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca 180 aggttcagcg gcggtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ctgtcaacag gctaacagtt tcccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6130 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6130 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6131 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6131 caggatatta gcagctgg 18 <210> 6132 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6132 Gln Asp Ile Ser Ser Trp 1 5 <210> 6133 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6133 gttgcatcc 9 <210> 6134 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6134 Val Ala Ser 1 <210> 6135 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6135 caacaggcta acagtttccc gtggacg 27 <210> 6136 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6136 Gln Gln Ala Asn Ser Phe Pro Trp Thr 1 5 <210> 6137 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6137 caggtgcagc tggtggagtc tggagcagag gtgaaaaagc ccggggaatc tctgaagatt 60 tcctgtaagg attctggata caggtttacc aagtcctgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tatcagatac 180 agcccgtcct tccaaggcca ggtcatcatc tcagccgaca agtccatcaa caccgcctac 240 ctgcagtggg acagcctgaa ggcctcggac accgccatgt attactgtgc gaaacaagcc 300 ggtataacaa gaagtatgtg ctttgactcc tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 6138 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6138 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Asp Ser Gly Tyr Arg Phe Thr Lys Ser 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Ile Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Asp Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Lys Gln Ala Gly Ile Thr Arg Ser Met Cys Phe Asp Ser Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6139 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6139 ggatacaggt ttaccaagtc ctgg 24 <210> 6140 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6140 Gly Tyr Arg Phe Thr Lys Ser Trp 1 5 <210> 6141 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6141 atctatcctg gtgactctga tatc 24 <210> 6142 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6142 Ile Tyr Pro Gly Asp Ser Asp Ile 1 5 <210> 6143 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6143 gcgaaacaag ccggtataac aagaagtatg tgctttgact cc 42 <210> 6144 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6144 Ala Lys Gln Ala Gly Ile Thr Arg Ser Met Cys Phe Asp Ser 1 5 10 <210> 6145 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6145 gacatcgtga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaaatca gagaattagc agctatttaa attggtatca gcagagacca 120 gggaaagccc ctaatctcct gatctatttt gcctccagtt tgcagagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ctatcaatag tctgcaacct 240 gaagattttg caacttacta ttgtcaacag agttacagta ttccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 6146 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6146 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Arg Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Phe Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6147 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6147 cagagaatta gcagctat 18 <210> 6148 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6148 Gln Arg Ile Ser Ser Tyr 1 5 <210> 6149 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6149 tttgcctcc 9 <210> 6150 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6150 Phe Ala Ser 1 <210> 6151 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6151 caacagagtt acagtattcc gtacact 27 <210> 6152 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6152 Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 1 5 <210> 6153 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6153 caggtgcagc tggtggagtc ggggggaggc ttggtacagc ctggcaggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttcat gattatgcca tacactgggt ccggcaagct 120 ccagggaagg gcctggactg ggtctcaggt attagttgga atagtgatac gatagcctat 180 gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatact 300 aacgatattt tgactggtta ttataaccct tttgactact ggggccaggg aaccatggtc 360 accgtctcct ca 372 <210> 6154 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6154 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asp Tyr 20 25 30 Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Asp Thr Ile Ala Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Thr Asn Asp Ile Leu Thr Gly Tyr Tyr Asn Pro Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 6155 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6155 ggattcacct ttcatgatta tgcc 24 <210> 6156 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6156 Gly Phe Thr Phe His Asp Tyr Ala 1 5 <210> 6157 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6157 attagttgga atagtgatac gata 24 <210> 6158 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6158 Ile Ser Trp Asn Ser Asp Thr Ile 1 5 <210> 6159 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6159 gcaaaagata ctaacgatat tttgactggt tattataacc cttttgacta c 51 <210> 6160 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6160 Ala Lys Asp Thr Asn Asp Ile Leu Thr Gly Tyr Tyr Asn Pro Phe Asp 1 5 10 15 Tyr <210> 6161 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6161 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctctgct gcatcgactt tgcaatcggg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caatttatta ctgtcaaaag tataacggtg acccattcac tttcggccct 300 gggaccaagg tggagatcaa acga 324 <210> 6162 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6162 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Ser Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Ile Tyr Tyr Cys Gln Lys Tyr Asn Gly Asp Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6163 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6163 cagggcatta gcaattat 18 <210> 6164 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6164 Gln Gly Ile Ser Asn Tyr 1 5 <210> 6165 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6165 gctgcatcg 9 <210> 6166 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6166 Ala Ala Ser 1 <210> 6167 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6167 caaaagtata acggtgaccc attcact 27 <210> 6168 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6168 Gln Lys Tyr Asn Gly Asp Pro Phe Thr 1 5 <210> 6169 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6169 gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctgggtt caccgtcagt aacaattata tgacctgggt ccgtcaggct 120 ccagggaagg ggctggaatg ggtctcagtt atttataccg gtgagaccac acactacgca 180 gactccgtga tgggccgatt caccatctcc agagacattt acaagaacac gctgtatctt 240 caaatgaaca gcctgagaac tgaggacacg gccgtgtatt actgtgcgag agatagaatc 300 acgatccgag actgcggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 6170 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6170 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Thr Gly Glu Thr Thr His Tyr Ala Asp Ser Val Met 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ile Tyr Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6171 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6171 gggttcaccg tcagtaacaa ttat 24 <210> 6172 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6172 Gly Phe Thr Val Ser Asn Asn Tyr 1 5 <210> 6173 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6173 atttataccg gtgagaccac a 21 <210> 6174 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6174 Ile Tyr Thr Gly Glu Thr Thr 1 5 <210> 6175 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6175 gcgagagata gaatcacgat ccgagactgc ggtatggacg tc 42 <210> 6176 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6176 Ala Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val 1 5 10 <210> 6177 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6177 gacatcctga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagaatcacc 60 atcacttgtc gggcgagtca ggatattagc agctggttag cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatgtt gcttccagtt tgcaaagtgg ggtcccagca 180 agattcagcg gcagtggatc tgagacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6178 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6178 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6179 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6179 caggatatta gcagctgg 18 <210> 6180 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6180 Gln Asp Ile Ser Ser Trp 1 5 <210> 6181 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6181 gttgcttcc 9 <210> 6182 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6182 Val Ala Ser 1 <210> 6183 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6183 ctacaagatt acaattaccc gtggacg 27 <210> 6184 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6184 Leu Gln Asp Tyr Asn Tyr Pro Trp Thr 1 5 <210> 6185 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6185 gaggtgcagc tggtggagtc tggaggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctgggtt caccgtcagt aacaattata tgacctgggt ccgccaggct 120 ccagggaagg ggctggaatg ggtctcagtt atttataccg gtgagaccac acactacgca 180 gactccgtga tgggccgatt caccatctcc agagacattt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagaac tgaggacacg gccgtgtatt attgtgcgag agatagaatc 300 acgatccgag actgcggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca 360 <210> 6186 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6186 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Thr Gly Glu Thr Thr His Tyr Ala Asp Ser Val Met 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val Trp Gly Gln 100 105 110 Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6187 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6187 gggttcaccg tcagtaacaa ttat 24 <210> 6188 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6188 Gly Phe Thr Val Ser Asn Asn Tyr 1 5 <210> 6189 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6189 atttataccg gtgagaccac a 21 <210> 6190 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6190 Ile Tyr Thr Gly Glu Thr Thr 1 5 <210> 6191 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6191 gcgagagata gaatcacgat ccgagactgc ggtatggacg tc 42 <210> 6192 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6192 Ala Arg Asp Arg Ile Thr Ile Arg Asp Cys Gly Met Asp Val 1 5 10 <210> 6193 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6193 gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagaatcacc 60 atcacttgtc gggcgagtca ggatattagc agctggttag cctggtatca gcagaaacca 120 ggaaaagccc ctaaactcct gatctatatt gcttccagtt tgcaaagtgg ggtcccagca 180 agattcagcg gcagtggatc tgagacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6194 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6194 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ile Ala Ser Ser Leu Gln Ser Gly Val Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6195 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6195 caggatatta gcagctgg 18 <210> 6196 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6196 Gln Asp Ile Ser Ser Trp 1 5 <210> 6197 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6197 attgcttcc 9 <210> 6198 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6198 Ile Ala Ser 1 <210> 6199 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6199 caacaggcta acagtttccc gtggacg 27 <210> 6200 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6200 Gln Gln Ala Asn Ser Phe Pro Trp Thr 1 5 <210> 6201 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6201 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120 ccagggaagg gactggaata tgtttcaggt ataagtggta atgggtatag tacatattat 180 gcagactctg tgaagggcag attcaccatc tccagagaca attccaagaa cacgctgtat 240 cttcaaatgg gcagcctgag acctgaggac atgtctgtgt attattgtgc gagaggggca 300 atgactggaa ccctcggagg gtttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 6202 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6202 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Ser Gly Ile Ser Gly Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Pro Glu Asp Met Ser Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ala Met Thr Gly Thr Leu Gly Gly Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6203 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6203 ggattcacct tcagtagcta tgct 24 <210> 6204 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6204 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 6205 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6205 ataagtggta atgggtatag taca 24 <210> 6206 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6206 Ile Ser Gly Asn Gly Tyr Ser Thr 1 5 <210> 6207 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6207 gcgagagggg caatgactgg aaccctcgga gggtttgact ac 42 <210> 6208 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6208 Ala Arg Gly Ala Met Thr Gly Thr Leu Gly Gly Phe Asp Tyr 1 5 10 <210> 6209 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6209 gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtgggaga cagagtcacc 60 atcacttgtc gggcgagtca ggacattaac aattatttag cctggtttca gcagaaacca 120 gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaatattttg caacttatta ctgccaacag tataatagtt tcccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6210 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6210 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Tyr Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6211 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6211 caggacatta acaattat 18 <210> 6212 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6212 Gln Asp Ile Asn Asn Tyr 1 5 <210> 6213 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6213 gctgcatcc 9 <210> 6214 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6214 Ala Ala Ser 1 <210> 6215 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6215 caacagtata atagtttccc gtggacg 27 <210> 6216 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6216 Gln Gln Tyr Asn Ser Phe Pro Trp Thr 1 5 <210> 6217 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6217 gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtacag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg gatggcagat atatggtatg atggaagtaa tacagactat 180 gtagactccg tgaagggccg attcaccatc tcaagagaca attccaagaa cacgttgtat 240 ctccaaatga acagcctgag agtcgaggac acggctgtgt attactgtgc gagagatcgg 300 catagtaaca gctggttaga ctacttagaa tattggggcc agggaaccct ggtcaccgtc 360 tcctca 366 <210> 6218 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6218 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Ala Asp Ile Trp Tyr Asp Gly Ser Asn Thr Asp Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg His Ser Asn Ser Trp Leu Asp Tyr Leu Glu Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6219 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6219 ggattcacct tcagtagcta tggc 24 <210> 6220 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6220 Gly Phe Thr Phe Ser Ser Tyr Gly 1 5 <210> 6221 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6221 atatggtatg atggaagtaa taca 24 <210> 6222 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6222 Ile Trp Tyr Asp Gly Ser Asn Thr 1 5 <210> 6223 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6223 gcgagagatc ggcatagtaa cagctggtta gactacttag aatat 45 <210> 6224 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6224 Ala Arg Asp Arg His Ser Asn Ser Trp Leu Asp Tyr Leu Glu Tyr 1 5 10 15 <210> 6225 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6225 gacatcctga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatca gcagacacca 120 gggaaagccc ctaagcgcct gatttatgct gcatccagtt tacaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca cagtcagcag cctgcagcct 240 gaagattttg caacttatta ctgtctacaa cataatagtc accctctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 6226 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6226 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 20 25 30 Leu Gly Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser His Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6227 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6227 caggacatta gaaatgat 18 <210> 6228 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6228 Gln Asp Ile Arg Asn Asp 1 5 <210> 6229 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6229 gctgcatcc 9 <210> 6230 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6230 Ala Ala Ser 1 <210> 6231 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6231 ctacaacata atagtcaccc tctcact 27 <210> 6232 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6232 Leu Gln His Asn Ser His Pro Leu Thr 1 5 <210> 6233 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6233 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagaggga 300 tttttggagt ggttattacc cgaatacttc cagcactggg gccagggcac catggtcacc 360 gtctcctca 369 <210> 6234 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6234 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Gly Phe Leu Glu Trp Leu Leu Pro Glu Tyr Phe Gln His 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 6235 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6235 ggattcacct ttagcagcta tgcc 24 <210> 6236 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6236 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 6237 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6237 attagtggta gtggtggtag caca 24 <210> 6238 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6238 Ile Ser Gly Ser Gly Gly Ser Thr 1 5 <210> 6239 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6239 gcgaaagagg gatttttgga gtggttatta cccgaatact tccagcac 48 <210> 6240 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6240 Ala Lys Glu Gly Phe Leu Glu Trp Leu Leu Pro Glu Tyr Phe Gln His 1 5 10 15 <210> 6241 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6241 gacatcgtga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcg gacgttcggc 300 caagggacca aggtggagat caaacga 327 <210> 6242 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6242 Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6243 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6243 cagagtgtta gcagcagcta c 21 <210> 6244 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6244 Gln Ser Val Ser Ser Ser Tyr 1 5 <210> 6245 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6245 ggtgcatcc 9 <210> 6246 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6246 Gly Ala Ser 1 <210> 6247 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6247 cagcagtatg gtagctcacc tcggacg 27 <210> 6248 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6248 Gln Gln Tyr Gly Ser Ser Pro Arg Thr 1 5 <210> 6249 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6249 caggtgcagc tggtggagtc tggaccagag gtgagaaagc ccggggagtc tctgaggatt 60 tcctgtaagg attctggaaa cagattaacc aacaactgga tcggctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggatc atctctcctg gtgactctga tatcagatac 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcaa caccgcctac 240 ctgcagtggt acagcctgaa ggcctcggac accgccatct attattgtgc gagacaagcc 300 ggtataacga gaagtatgtg ctttgactat tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 6250 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6250 Gln Val Gln Leu Val Glu Ser Gly Pro Glu Val Arg Lys Pro Gly Glu 1 5 10 15 Ser Leu Arg Ile Ser Cys Lys Asp Ser Gly Asn Arg Leu Thr Asn Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Ser Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 65 70 75 80 Leu Gln Trp Tyr Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gln Ala Gly Ile Thr Arg Ser Met Cys Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6251 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6251 ggaaacagat taaccaacaa ctgg 24 <210> 6252 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6252 Gly Asn Arg Leu Thr Asn Asn Trp 1 5 <210> 6253 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6253 atctctcctg gtgactctga tatc 24 <210> 6254 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6254 Ile Ser Pro Gly Asp Ser Asp Ile 1 5 <210> 6255 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6255 gcgagacaag ccggtataac gagaagtatg tgctttgact at 42 <210> 6256 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6256 Ala Arg Gln Ala Gly Ile Thr Arg Ser Met Cys Phe Asp Tyr 1 5 10 <210> 6257 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6257 gacatcgtga tgacccagtc tccatcttcc ctgtctgcat ctgtaggaga cagagtcacc 60 gtcacttgcc gggcaagtca gagaattaac agctatttaa attggtatca gcaaagacca 120 gggatagccc ctaagctcct gatctatttt gcatccagtt tacagagtgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgctacct 240 gaagattttg caatttacta ctgtcaacag acttacatta tcccgtacac ttttggccag 300 gggaccaagg tggagatcaa acga 324 <210> 6258 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6258 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Arg Ile Asn Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Arg Pro Gly Ile Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Phe Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Leu Pro 65 70 75 80 Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Thr Tyr Ile Ile Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6259 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6259 cagagaatta acagctat 18 <210> 6260 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6260 Gln Arg Ile Asn Ser Tyr 1 5 <210> 6261 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6261 tttgcatcc 9 <210> 6262 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6262 Phe Ala Ser 1 <210> 6263 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6263 caacagactt acattatccc gtacact 27 <210> 6264 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6264 Gln Gln Thr Tyr Ile Ile Pro Tyr Thr 1 5 <210> 6265 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6265 gaggtgcagc tggtggagtc tggggggggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120 ccagggaagg gactggaata tgtttcagct attagtggta gtgggtatag cacatattat 180 gcagactctg tgaagggcag attcaccatc tccagagaca attccaagaa cacgctgtat 240 cttcaaatgg gcagcctgag acctgaggac atggctgtgt attactgtgc gagaggggca 300 atgactggaa ccctcggagg gtttgactac tggggccagg gaaccctggt caccgtctcc 360 tca 363 <210> 6266 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6266 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Gly Ser Leu Arg Pro Glu Asp Met Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ala Met Thr Gly Thr Leu Gly Gly Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6267 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6267 ggattcacct tcagtagcta tgct 24 <210> 6268 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6268 Gly Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 6269 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6269 attagtggta gtgggtatag caca 24 <210> 6270 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6270 Ile Ser Gly Ser Gly Tyr Ser Thr 1 5 <210> 6271 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6271 gcgagagggg caatgactgg aaccctcgga gggtttgact ac 42 <210> 6272 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6272 Ala Arg Gly Ala Met Thr Gly Thr Leu Gly Gly Phe Asp Tyr 1 5 10 <210> 6273 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6273 gacatcctga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgtc gggcgagtca ggacattagc aattatttag cctggtttca gcagaaacca 120 gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180 aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaattttttg caacttatta ctgccaacag tataatagtt tcccgtggac gttcggccaa 300 gggaccaagg tggagatcaa acga 324 <210> 6274 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6274 Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Phe Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6275 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6275 caggacatta gcaattat 18 <210> 6276 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6276 Gln Asp Ile Ser Asn Tyr 1 5 <210> 6277 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6277 gctgcatcc 9 <210> 6278 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6278 Ala Ala Ser 1 <210> 6279 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6279 caacagtata atagtttccc gtggacg 27 <210> 6280 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6280 Gln Gln Tyr Asn Ser Phe Pro Trp Thr 1 5 <210> 6281 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6281 caggtgcagc tggtggagtc tggagcagag gtgaaaaagt ccggggagtc tctgaagatc 60 tcctgtaagg gttctgaaaa caactttgcc aactactgga tcgcctgggt gcgccagatg 120 cccgggaaag gcctggagtg gatggggctc atctaccctg gtgactctga taccagatat 180 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag taccgcctac 240 ttgcagtgga acagcctgaa gacctcggac acctccatgt attactgtgc gagacagctg 300 cgctatatca cctcgtcggg ttcttttgat atctggggcc aaggaacaat ggtcaccgtc 360 tcttca 366 <210> 6282 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6282 Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Ser Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Glu Asn Asn Phe Ala Asn Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Asn Ser Leu Lys Thr Ser Asp Thr Ser Met Tyr Tyr Cys 85 90 95 Ala Arg Gln Leu Arg Tyr Ile Thr Ser Ser Gly Ser Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 6283 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6283 gaaaacaact ttgccaacta ctgg 24 <210> 6284 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6284 Glu Asn Asn Phe Ala Asn Tyr Trp 1 5 <210> 6285 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6285 atctaccctg gtgactctga tacc 24 <210> 6286 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6286 Ile Tyr Pro Gly Asp Ser Asp Thr 1 5 <210> 6287 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6287 gcgagacagc tgcgctatat cacctcgtcg ggttcttttg atatc 45 <210> 6288 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6288 Ala Arg Gln Leu Arg Tyr Ile Thr Ser Ser Gly Ser Phe Asp Ile 1 5 10 15 <210> 6289 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6289 gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc 60 atcacttgcc gggcaagtca gaccattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctatggt gtatccaatt tgcaaagtgc tgtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaacag acttacagtc tcccgctcac tttcggcgga 300 gggaccaagg tggaaatcaa acga 324 <210> 6290 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6290 Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Val Ser Asn Leu Gln Ser Ala Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Leu Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6291 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6291 cagaccatta gcagctat 18 <210> 6292 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6292 Gln Thr Ile Ser Ser Tyr 1 5 <210> 6293 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6293 ggtgtatcc 9 <210> 6294 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6294 Gly Val Ser 1 <210> 6295 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6295 caacagactt acagtctccc gctcact 27 <210> 6296 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6296 Gln Gln Thr Tyr Ser Leu Pro Leu Thr 1 5 <210> 6297 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6297 gaggtgcagc tggtggagtc tgggggaggc ttggttcagc ctggggggtc cctgagactc 60 tcctgtgcag cctctagatt cacctttagc agttatgcca tgacctgggt ccgccaggct 120 ccagggaagg ggctggactg ggtctccact attagtgcag gtggtactac cacacactac 180 accccgtccg tgaagggccg gttcaccatc tccagagaca attccaataa aacgctgttt 240 ctgcaaatga gtagcctgag agccgaggac tcggccgtat attactgtgc gaagatggat 300 acagctatgg ccctctatta tttctacggt atggacgtct ggggccaagg gaccacggtc 360 accgtctcct ca 372 <210> 6298 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6298 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 35 40 45 Ser Thr Ile Ser Ala Gly Gly Thr Thr Thr His Tyr Thr Pro Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Lys Thr Leu Phe 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Met Asp Thr Ala Met Ala Leu Tyr Tyr Phe Tyr Gly Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 6299 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6299 agattcacct ttagcagtta tgcc 24 <210> 6300 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6300 Arg Phe Thr Phe Ser Ser Tyr Ala 1 5 <210> 6301 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6301 attagtgcag gtggtactac caca 24 <210> 6302 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6302 Ile Ser Ala Gly Gly Thr Thr Thr 1 5 <210> 6303 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6303 gcgaagatgg atacagctat ggccctctat tatttctacg gtatggacgt c 51 <210> 6304 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6304 Ala Lys Met Asp Thr Ala Met Ala Leu Tyr Tyr Phe Tyr Gly Met Asp 1 5 10 15 Val <210> 6305 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6305 gacatcctga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgct gggccagtca ggacattacc aattatttag cctggtatca gcgaaaacca 120 gggaaagccc ctaaactcct gatctatggt gcatccactt tgcaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tggaacggaa ttcactctca caatcagcag cctgcagcct 240 gaggattttg cagtttatta ctgtcaacag cttgatagtt acccgctcac tttcggcgga 300 gggaccaagg tggagatcaa acga 324 <210> 6306 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6306 Asp Ile Leu Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Asp Ile Thr Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Arg Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Asp Ser Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 6307 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6307 caggacatta ccaattat 18 <210> 6308 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6308 Gln Asp Ile Thr Asn Tyr 1 5 <210> 6309 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6309 ggtgcatcc 9 <210> 6310 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6310 Gly Ala Ser 1 <210> 6311 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6311 caacagcttg atagttaccc gctcact 27 <210> 6312 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6312 Gln Gln Leu Asp Ser Tyr Pro Leu Thr 1 5 <210> 6313 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6313 gaggtgcagc tggtggagtc tgggggaggt gtggtgcggc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagtt 120 ccagggaagg ggctggagtg ggtctctggt attaattgga atggtgatag tagaggttat 180 gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240 ctgcaaatga acagtctgag agccgaggac acggccttat atttttgtgc gaaagatggt 300 cctgtaacac cagctgatac ttactggtac ttcgatctct ggggccgtgg caccctggtc 360 accgtctcct ca 372 <210> 6314 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6314 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Trp Asn Gly Asp Ser Arg Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 85 90 95 Ala Lys Asp Gly Pro Val Thr Pro Ala Asp Thr Tyr Trp Tyr Phe Asp 100 105 110 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 6315 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6315 ggattcacct ttgatgatta tggc 24 <210> 6316 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6316 Gly Phe Thr Phe Asp Asp Tyr Gly 1 5 <210> 6317 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6317 attaattgga atggtgatag taga 24 <210> 6318 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6318 Ile Asn Trp Asn Gly Asp Ser Arg 1 5 <210> 6319 <211> 51 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6319 gcgaaagatg gtcctgtaac accagctgat acttactggt acttcgatct c 51 <210> 6320 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6320 Ala Lys Asp Gly Pro Val Thr Pro Ala Asp Thr Tyr Trp Tyr Phe Asp 1 5 10 15 Leu <210> 6321 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6321 gacatcctga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggccagtca gagtattagt acctggttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagttact gatctatacg gcgtctactt tagaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctacagcct 240 gatgattttg caacttatta ctgccaaaat tataatagtt attcgatcac cttcggccaa 300 gggacacgac tggagattaa acga 324 <210> 6322 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6322 Asp Ile Leu Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Thr Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Asn Ser Tyr Ser Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 100 105 <210> 6323 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6323 cagagtatta gtacctgg 18 <210> 6324 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6324 Gln Ser Ile Ser Thr Trp 1 5 <210> 6325 <211> 9 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6325 acggcgtct 9 <210> 6326 <211> 3 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6326 Thr Ala Ser 1 <210> 6327 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> synthetic <400> 6327 caaaattata atagttattc gatcacc 27 <210> 6328 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> synthetic <400> 6328 Gln Asn Tyr Asn Ser Tyr Ser Ile Thr 1 5

Claims (36)

  1. 인플루엔자 A 헤마글루티닌 (HA)에 특이적으로 결합하는 분리된 재조합 항체 또는 이것의 항원-결합 단편으로서, 항체 또는 이것의 항원-결합 단편은
    i) (a) 서열번호: 20의 HCDR1, (b) 서열번호: 22의 HCDR2; (c) 서열번호: 24의 HCDR3; (d) 서열번호: 28의 LCDR1; (e) 서열번호: 30의 LCDR2 및 (f) 서열번호: 32의 LCDR3, 또는
    ii) (a) 서열번호: 52의 HCDR1, (b) 서열번호: 54의 HCDR2; (c) 서열번호: 56의 HCDR3; (d) 서열번호: 68의 LCDR1; (e) 서열번호: 70의 LCDR2 및 (f) 서열번호: 72의 LCDR3
    을 포함하는, 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  2. 제1 항에 있어서, 항체 또는 이것의 항원 결합 단편은
    (a) 완전한 인간 단클론성 항체이다;
    (b) 실시간 생체막 간섭계 기반 바이오센서로 측정된 것으로서 10-9M 미만의 해리 상수 (KD)로 인플루엔자 HA에 결합한다;
    (c) 370분 초과의 해리 반감기 (t½)를 나타낸다;
    (d) H1N1, H5N1, H9N2, H13N6 및 H16N3으로부터 선택된 1군 인플루엔자 A 바이러스의 중화를 나타내며, IC50은 130nM 미만이다;
    (e) 인플루엔자 바이러스 감염된 세포의 보체 매개 용해를 나타내며 EC50은 66nM 미만이다; 및
    (f) 인플루엔자 바이러스 감염의 동물 모델에서 바이러스 공격접종 이전 또는 이후 투여될 때 상기 항체 또는 이것의 항원 결합 단편이 투여되지 않았을 때와 비교하여 증가된 생존률을 나타낸다
    는 특징들 중 둘 이상을 가지는, 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  3. 제1 항에 있어서, 항체는 원숭이에서 Control I mAb보다 1.5배 더 큰 해리 반감기 및 마우스에서 Control I mAb보다 2배 더 큰 해리 반감기를 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  4. 제1 항에 있어서, 항체는 감염 후 48시간에 투여될 때, 오셀타미비르와 비교하여 인플루엔자 바이러스 감염된 포유동물에서 증가된 생존률을 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  5. 제1 항에 있어서, 항체는 5 mg/kg 내지 25 mg/kg의 용량으로 5일 동안 1일 2회 투여된 오셀타미비르의 경구 투여와 비교하여 15 mg/kg의 1회 정맥 내 용량으로서 인플루엔자 바이러스 감염된 포유동물에 투여될 때 증가된 생존률을 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  6. 제1 항에 있어서, 항체는 감염 후 48시간에 15 mg/kg의 1회 용량으로 투여될 때, 인플루엔자 바이러스 감염된 포유동물에서 100%의 생존률을 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  7. 제1 항에 있어서, 항체는 25 mg/kg의 용량으로 5일 동안 1일 2회 경구 투여될 때 오셀타미비르로 관찰된 40% 생존률과 비교하여 15 mg/kg의 1회 용량으로 투여될 때 인플루엔자 바이러스로 감염된 포유동물에서 100%의 생존률을 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  8. 제1 항에 있어서, 항체는 감염 후 72시간에 오셀타미비르와 함께 투여될 때 인플루엔자 바이러스로 감염된 포유동물에서 오셀타미비르가 단독으로 투여될 때와 비교하여 증가된 생존률을 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  9. 제1 항에 있어서, 항체는 오셀타미비르와 조합하여 사용될 때, 항체가 7 mg/kg 내지 15 mg/kg의 범위의 1회 정맥 내 용량으로 투여되고 오셀타미비르가 25 mg/kg의 용량으로 5일 동안 1일 2회 경구 투여되는 경우 오셀타미비르가 단독으로 투여될 때와 비교하여 증가된 생존률을 나타내는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  10. 제1 항에 있어서, 서열 번호: 18 또는 50으로 구성된 중쇄 가변 영역(HCVR)을 포함하는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  11. 제1 항에 있어서, 서열 번호: 26 또는 66으로 구성된 경쇄 가변 영역(LCVR)을 포함하는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  12. 제1 항에 있어서, 서열 번호: 18/26으로 구성된 HCVR/LCVR 아미노산 서열 쌍을 포함하는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  13. 제1 항에 있어서, 서열 번호: 50/66으로 구성된 HCVR/LCVR 아미노산 서열 쌍을 포함하는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  14. 제1 항에 있어서, 항체는 숙주 세포로의 인플루엔자 바이러스의 부착 및/또는 진입을 방지하는 것을 특징으로 하는 분리된 재조합 항체 또는 이것의 항원-결합 단편.
  15. 제1 항 내지 제14 항 중 어느 한 항에 제시된 항체의 HCVR을 암호화하는 폴리뉴클레오타이드 서열을 포함하는 제1 핵산 분자, 및 LCVR을 암호화하는 폴리뉴클레오타이드 서열을 포함하는 제2 핵산 분자를 포함하는, 조성물.
  16. 제1 항 내지 제14 항 중 어느 한 항에 제시된 항체의 HCVR을 암호화하는 폴리뉴클레오타이드 서열을 포함하는 제1 핵산 분자, 및 LCVR을 암호화하는 폴리뉴클레오타이드 서열을 포함하는 제2 핵산 분자를 포함하는, 숙주 세포.
  17. 제16 항에 있어서, HCVR을 암호화하는 폴리뉴클레오타이드 서열을 포함하는 제1 핵산 분자가 발현 벡터 내에 있는 것을 특징으로 하는 숙주 세포.
  18. 제16 항에 있어서, LCVR을 암호화하는 폴리뉴클레오타이드 서열을 포함하는 제2 핵산 분자가 발현 벡터 내에 있는 것을 특징으로 하는 숙주 세포.
  19. 인플루엔자 바이러스 감염을 예방, 치료 또는 경감하기 위한 약학적 조성물로서, 제1 항 내지 제14 항 중 어느 한 항의 분리된 재조합 항체 또는 이것의 항원-결합 단편 및 약학적으로 허용 가능한 담체 또는 희석제를 포함하는, 약학적 조성물.
  20. 제19 항에 있어서, 약학적 조성물은 열, 기침, 근육통, 비루, 숨가쁨, 폐렴 또는 기관지염으로 구성된 군으로부터 선택되는 인플루엔자 바이러스 감염으로 인한 하나 이상의 증상을 예방, 치료 또는 경감하는 것을 특징으로 하는 약학적 조성물.
  21. 제19 항에 있어서, 약학적 조성물은 대상체에게 예방적으로 또는 치료적으로 투여되는 것을 특징으로 하는 약학적 조성물.
  22. 제21 항에 있어서, 약학적 조성물은 면역 손상된 개체, 65세를 초과한 고령의 성인, 의료계 종사자 및 기저 질환의 병력을 가진 사람으로 구성된 군으로부터 선택된 대상체에게 예방적으로 투여되는 것을 특징으로 하는 약학적 조성물.
  23. 제22 항에 있어서, 기저 질환은 심장병 또는 당뇨병인 것을 특징으로 하는 약학적 조성물.
  24. 제19 항에 있어서, 약학적 조성물은 항바이러스제, 항염증제, 인플루엔자 HA에 대한 다른 항체, 인플루엔자에 대한 백신, 식이보충제 및 인플루엔자 감염을 치료하기 위한 임의의 다른 완화 요법으로 구성된 군으로부터 선택되는 제2 치료제와 조합하여 투여되는 것을 특징으로 하는 약학적 조성물.
  25. 제24 항에 있어서, 항염증제는 코르티코스테로이드 또는 비-스테로이드성 항염증제인 것을 특징으로 하는 약학적 조성물.
  26. 제24 항에 있어서, 식이보충제는 항산화제인 것을 특징으로 하는 약학적 조성물.
  27. 제24 항에 있어서, 제2 치료제는 항체와 같은 투여 경로를 통해 또는 항체와 다른 투여 경로를 통해 투여되는 것을 특징으로 하는 약학적 조성물.
  28. 제27 항에 있어서, 제2 치료제는 경구로 투여되는 것을 특징으로 하는 약학적 조성물.
  29. 제24 항에 있어서, 항바이러스제는 오셀타미비르인 것을 특징으로 하는 약학적 조성물.
  30. 제29 항에 있어서, 오셀타미비르는 항체의 투여 이전에, 투여와 동시에, 또는 투여 이후에 투여되는 것을 특징으로 하는 약학적 조성물.
  31. 제19 항에 있어서, 약학적 조성물은 피하로, 정맥 내로, 피부 내로, 근육 내로, 비강 내로, 또는 경구로 투여되는 것을 특징으로 하는 약학적 조성물.
  32. 항인플루엔자 A 헤마글루티닌(HA) 항체 또는 이것의 항원-결합 단편을 생산하는 방법으로서, 항체 또는 이것의 항원-결합 단편의 생산을 허용하는 조건 하에서 제16 항의 숙주 세포를 배양하는 단계를 포함하고, 선택적으로 생산된 항체 또는 이것의 항원-결합 단편을 회수하는 단계를 포함하는, 방법.
  33. 삭제
  34. 삭제
  35. 삭제
  36. 삭제
KR1020177020050A 2014-12-19 2015-12-18 인플루엔자 헤마글루티닌에 대한 인간 항체 Active KR102729973B1 (ko)

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