KR102796519B1 - Skin whitening composition for oral administration comprising glutathione - Google Patents

Abstract

An oral skin whitening composition containing glutathione is disclosed. The oral skin whitening composition according to the present invention is an oral composition for moisture and nutrition intake, which contains glucose and taurine as components helpful for nutrition necessary for the human body and various physiological activities, and glutathione and vitamin C as components exhibiting a skin whitening effect.

Description

{SKIN WHITENING COMPOSITION FOR ORAL ADMINISTRATION COMPRISING GLUTATHIONE}

The present invention relates to a skin whitening composition for oral administration, and more specifically, to a skin whitening composition for oral administration having a skin whitening effect, which is provided as a health supplement or health functional food to be taken with an appropriate amount of water to enable the intake of nutrients necessary for the human body along with palatability for smooth water intake, or as a pharmaceutical product.

Water is an essential element for humans to maintain life and health, accounting for approximately 60% of an adult's body weight. It plays an important role in maintaining blood volume, supplying nutrients to the body, and excreting waste.

Adequate water is essential for maintaining homeostasis, boosting immunity, and preventing constipation. The daily water requirement varies depending on age, weight, temperature, activity level, and body calorie consumption. According to the National Health and Nutrition Survey data of the Korean Nutrient Intake Standard, approximately 62% of the population does not meet the water intake standard, which highlights the importance of water intake.

Considering these circumstances, various water supplement products or energy/sports drinks that contain the nutrients necessary for the human body along with palatability have been developed recently to facilitate smooth water intake and are widely sold as health supplements or health functional foods.

However, these conventional moisture supplement products only provide commonly known nutritional ingredients that help with smooth moisture intake and fatigue recovery, so they have limitations in meeting the needs of recent consumers who expect combined effects such as skin improvement along with the need for moisture and nutrition intake.

Related prior art documents include Patent Registration No. 10-2105111 (Title of the invention: Energy drink composition with enhanced physiologically active ingredients and its manufacturing method, Publication date: April 27, 2020) and Patent Registration No. 10-2435548 (Title of the invention: Liquid stick-type energy sports drink, Publication date: August 26, 2022).

The purpose of the present invention is to provide a skin whitening composition for oral administration, which enables the intake of nutrients necessary for the human body along with palatability for smooth water intake in health supplements, health functional foods, pharmaceuticals, etc., while also exhibiting a skin whitening effect.

The above object is achieved by an oral skin whitening composition comprising glutathione, characterized in that it comprises glucose and glutathione as components in an oral composition for moisture and nutrition intake, according to one embodiment of the present invention.

Preferably, the glutathione may be provided as L-glutathione yeast extract.

Preferably, the skin whitening composition for oral administration may further comprise vitamin C as a component.

Preferably, the glutathione may be included in an amount of 2 to 8 wt% based on the total weight of the skin whitening composition for oral administration, and the vitamin C may be included in an amount of 1 to 5 wt% based on the total weight of the skin whitening composition for oral administration.

Preferably, the skin whitening composition for oral administration may further comprise taurine and purified salt as components.

Preferably, the glutathione may be included in an amount of 2 to 8 wt% based on the total weight of the skin whitening composition for oral administration, the vitamin C may be included in an amount of 1 to 5 wt% based on the total weight of the skin whitening composition for oral administration, the taurine may be included in an amount of 2 to 8 wt% based on the total weight of the skin whitening composition for oral administration, and the refined salt may be included in an amount of 0.5 to 1.5 wt% based on the total weight of the skin whitening composition for oral administration.

Preferably, the skin whitening composition for oral administration is prepared in a powder form so that the user can mix it with an appropriate amount of water and ingest it.

The present invention relates to a skin whitening composition for oral administration provided as a health supplement, health functional food, medicine, etc., which comprises components that are helpful for nutrition and various physiological activities necessary for the human body and components that exhibit a skin whitening effect, thereby enabling the intake of nutrients necessary for the human body along with palatability for smooth water intake, while exhibiting a skin whitening effect.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, in explaining the present invention, descriptions of functions or configurations already known will be omitted in order to clarify the gist of the present invention.

The present invention relates to a skin whitening composition for oral administration provided as a health supplement/health functional food or as a pharmaceutical product. That is, the skin whitening composition for oral administration according to the present invention enables the intake of nutrients necessary for the human body along with palatability for smooth water intake, while exhibiting a skin whitening effect, and may be a skin whitening functional food (health supplement/health functional food) or a skin whitening pharmaceutical composition.

The skin whitening composition for oral administration according to the present invention contains components that are helpful for nutrition and various physiological activities required by the human body, and components that exhibit a skin whitening effect. In addition, the skin whitening composition for oral administration according to the present invention is preferably manufactured in a powder or powder form so that a user (intake user) can mix it with an appropriate amount of water and ingest it. Preferably, the skin whitening composition for oral administration according to the present invention is packaged in a single sachet for the user's convenience. For example, in the case of packaging in a 10g unit per sachet, it may be recommended to mix it with 250 to 350ml of water and ingest it. However, differently from this, the skin whitening composition for oral administration according to the present invention may be manufactured in a tablet form.

Hereinafter, the specific combination and content of the components that provide nutrition necessary for the human body and help with various physiological activities, the components that exert a skin whitening effect, and other functional components of the skin whitening composition for oral administration according to the present invention will be described in detail.

An oral skin whitening composition according to one embodiment of the present invention comprises glucose and taurine as components that are helpful for nutrition and various physiological activities required by the human body, and glutathione and vitamin C as components that exhibit a skin whitening effect. In addition, an oral skin whitening composition according to one embodiment of the present invention further comprises purified salt as a component.

Here, glucose is preferably provided as anhydrous crystalline glucose and is contained in an amount of 42 to 72 wt% based on the total weight (100 wt%) of the skin whitening composition for oral administration, and taurine is preferably contained in an amount of 2 to 8 wt% based on the total weight of the skin whitening composition for oral administration. In addition, glutathione is provided as L-glutathione yeast extract and is preferably contained in an amount of 2 to 8 wt% based on the total weight of the skin whitening composition for oral administration, vitamin C is preferably contained in an amount of 1 to 5 wt% based on the total weight of the skin whitening composition for oral administration, and refined salt is preferably contained in an amount of 0.5 to 1.5 wt% based on the total weight of the skin whitening composition for oral administration.

That is, the skin whitening composition for oral administration according to one embodiment of the present invention preferably contains 42 to 72 wt% of glucose (anhydrous crystalline glucose), 2 to 8 wt% of taurine, 2 to 8 wt% of glutathione (L-glutathione yeast extract), 1 to 5 wt% of vitamin C, and 0.5 to 1.5 wt% of refined salt with respect to the total weight (100 wt%) of the composition. More preferably, the skin whitening composition for oral administration according to one embodiment of the present invention may contain 47 to 57 wt% of glucose (anhydrous crystalline glucose), 3 to 7 wt% of taurine, 3 to 7 wt% of glutathione (L-glutathione yeast extract), 2 to 4 wt% of vitamin C, and 0.75 to 1.25 wt% of refined salt with respect to the total weight of the composition. And, most preferably, the oral skin whitening composition according to one embodiment of the present invention may contain 56.83 wt% of glucose (anhydrous crystalline glucose), 5 wt% of taurine, 5 wt% of glutathione (L-glutathione yeast extract), 3 wt% of vitamin C, and 1 wt% of refined salt based on the total weight thereof.

Glucose is an essential element in the human body. It is broken down through cellular respiration to create energy, and is an important energy source, especially for the brain and red blood cells. Glucose is a type of monosaccharide and is a material for disaccharides (glucose + glucose), sucrose (glucose + fructose), lactose (glucose + galactose), and a component of polysaccharides such as glycogen, starch, and cellulose. Our body regulates blood sugar levels within a certain range through hormones called insulin and glucagon. When the concentration of glucose in the blood is high, insulin is secreted to move glucose to the liver and muscles, and the remaining glucose is synthesized into glycogen and stored in the liver and muscles, whereas when the concentration of glucose in the blood is low, glucagon is secreted to break down glycogen in the liver to create glucose, thereby maintaining blood sugar levels at a normal level.

Taurine is a type of amino acid that is necessary for various physiological activities of the human body. In addition to making bile, it has many biological functions and is essential for making the musculoskeletal system and maintaining the function of the cardiovascular system. It can pass through the blood-brain barrier, so it can regulate the functions of the central nervous system, such as blocking neurotransmitters and strengthening the function of the hippocampus. In addition, taurine is known to block active oxygen in the body, regulate osmotic pressure, maintain calcium homeostasis, and control adipose tissue to suppress obesity.

Glutathione is a crystalline peptide composed of three amino acids, glutamic acid, cysteine, and glycine, and is an antioxidant that exists in the cells of microorganisms, plants, and animals. Glutathione is synthesized in the human body in reduced and oxidized forms, but as the human body ages, glutathione content and metabolic enzymes decrease. Due to metabolic products and free radicals generated in the human body, toxins generated by external environmental factors, the human body's functions decline, immunity decreases, and aging is accelerated due to chronic fatigue, making it susceptible to various diseases. Glutathione is known to help directly detoxify the causative agent. In addition, glutathione is an antioxidant for oxidative damage, and can prevent damage to important components of cells due to active oxygen. It has been reported to have various pharmacological effects, such as improving liver disease, treating diabetes, and anticancer activity. In the present invention, glutathione exhibits a skin whitening effect together with vitamin C.

Vitamin C, also known as ascorbic acid, synthesizes collagen and acts as an antioxidant. In addition, vitamin C is known to help the absorption of iron in the small intestine and to be involved in the biosynthesis of carnitine and immune function. If vitamin C is insufficient, scurvy, abnormalities in collagen synthesis, abnormalities in connective tissue, bone pain, fractures, diarrhea, etc. may occur, and if it is excessive, gastrointestinal disorders such as nausea, abdominal pain, and diarrhea may occur. This vitamin C, together with glutathione in the present invention, exerts a skin whitening effect and promotes glutathione production.

Meanwhile, the oral skin whitening composition according to one embodiment of the present invention further includes other functional components, such as orange juice powder, sodium citrate, orange flavor powder, DL-malic acid, orange color SMP, enzyme-treated stevia, sucralose, biotin mixture, vitamin B6 hydrochloride, vitamin B1 hydrochloride, and vitamin B12 mixture.

Here, it is preferable that the oral skin whitening composition according to one embodiment of the present invention further contains 5 to 15 wt% of orange juice powder, 5 to 15 wt% of sodium citrate, 2.5 to 7.5 wt% of orange flavor powder, 2 to 4 wt% of DL-malic acid, 0.5 to 1.5 wt% of enzyme-treated stevia, 0.05 to 0.15 wt% of orange-colored SMP, 0.01 to 0.05 wt% of sucralose, 0.005 to 0.015 wt% of biotin mixture, 0.005 to 0.015 wt% of vitamin B6 hydrochloride, 0.005 to 0.015 wt% of vitamin B1 hydrochloride, 0.001 to 0.009 wt% of hyaluronic acid mixture, and 0.001 to 0.009 wt% of vitamin B12 mixture, based on the total weight (100 wt%) of the composition.

And, most preferably, the oral skin whitening composition according to one embodiment of the present invention may further include 10 wt% of orange juice powder, 10 wt% of sodium citrate, 5 wt% of orange flavor powder, 3 wt% of DL-malic acid, 1 wt% of enzyme-treated stevia, 0.1 wt% of orange-colored SMP, 0.03 wt% of sucralose, 0.01 wt% of biotin mixture, 0.01 wt% of vitamin B6 hydrochloride, 0.01 wt% of vitamin B1 hydrochloride, 0.005 wt% of hyaluronic acid mixture, and 0.005 wt% of vitamin B12 mixture, based on the total weight of the composition.

Hereinafter, the components and effects of the present invention will be described in more detail by describing preferred embodiments of the present invention and test results thereof. However, these are presented as preferred examples of the present invention, and the present invention is not limited or restricted by the embodiments disclosed below.

1. Composition and content of preferred embodiment of the present invention

A skin whitening composition for oral administration according to a preferred embodiment of the present invention applied to this test comprises 56.83 wt% of glucose (anhydrous crystalline glucose), 5 wt% of taurine, 5 wt% of glutathione (L-glutathione yeast extract), 3 wt% of vitamin C, and 1 wt% of refined salt as components based on the total weight (100 wt%) of the composition, and is manufactured in a powder or powder form for the test subject to ingest by mixing it with an appropriate amount of water.

Here, the oral skin whitening composition according to a preferred embodiment of the present invention applied to this test is packaged in units of 10 g per pack for easy ingestion by test subjects, and contains 5,683 mg of anhydrous crystalline glucose, 500 mg of taurine, 500 mg of L-glutathione yeast extract, 300 mg of vitamin C, and 100 mg of refined salt per pack (10 g).

In addition, the oral skin whitening composition according to a preferred embodiment of the present invention applied to this test further comprises, as other components, 10 wt% of orange juice powder, 10 wt% of sodium citrate, 5 wt% of orange flavor powder, 3 wt% of DL-malic acid, 1 wt% of enzyme-treated stevia, 0.1 wt% of orange color SMP, 0.03 wt% of sucralose, 0.01 wt% of biotin mixture, 0.01 wt% of vitamin B6 hydrochloride, 0.01 wt% of vitamin B1 hydrochloride, 0.005 wt% of hyaluronic acid mixture, and 0.005 wt% of vitamin B12 mixture, based on the total weight of the composition.

2. Test Overview and Test Method

In a human application test, 36 subjects (test group) who took the oral skin whitening composition product manufactured in a powder or powder formulation unit according to the present example with the above components and contents for 6 weeks and 38 subjects (control group) who did not take the oral skin whitening composition product according to the present example were observed for changes in facial skin such as pores, wrinkles, and pigmentation, and stability was evaluated through blood tests for various items.

Here, the test subjects were selected as healthy women aged 20 to 49 years, but those with underlying diseases such as infectious diseases, tumors, digestive system disorders, hypersensitivity, a history of anaphylactic reactions, family members with ongoing or past autoimmune diseases, and mental illnesses, etc., who were judged to be unsuitable by the test manager, were excluded. In addition, all subjects participating in the test visited the outpatient clinic at set intervals during the follow-up observation period and underwent blood tests and skin condition measurements before and after intake for 6 weeks. In addition, the overall satisfaction with the intake of the skin whitening composition for oral administration according to this example and the intake compliance were confirmed through a questionnaire, and adverse reactions and complications were investigated. At this time, the same protocol was applied to the intake group (test group) and the non-intake group (control group), and the follow-up observation period was also applied equally.

The intake group mixed the oral skin whitening composition product according to this example into 250-350㎖ of water and took two packets a day. The basic conditions of the intake group and the non-intake group were set so that there was no statistical difference in all items, as shown in [Table 1] below. At this time, there was no difference in systolic blood pressure, diastolic blood pressure, or pulse between the intake group and the non-intake group before and after 6 weeks, and the skin analysis area was also set so that there was no statistical difference.

3. Test Results and Analysis

The skin measurement results before and after 6 weeks of intake and non-intake of the intake group are summarized in [Table 2] below. Using a Mark Vu (PSI Plus®) skin measuring device, the following items were measured: pores, wrinkles, pigmentation, melanin, redness, brown pigment, sebum, porphyrin, skin tone, radiance area, radiance brightness, and moisture. As shown in [Table 2] below, it was confirmed that the values of melanin and brown pigment items in the intake group were statistically significantly improved.

For reference, the Mark Vu (PSI Plus®) skin analyzer is a device that precisely measures and analyzes skin conditions using LED light sources (normal light, polarized light, glossy light, UV light), and can measure and analyze pores, wrinkles, skin tone (brightness), radiance, pigmentation, melanin, sebum, porphyrin, etc.

The blood test results of the intake group before and after 6 weeks of intake are summarized in [Table 3] below. Except for the level of Hb Ale (glycated hemoglobin), there was no statistically significant difference in the blood test results before and after 6 weeks of intake, confirming the stability of the intake for 6 weeks. In addition, the level of glycated hemoglobin was confirmed to have statistically significantly improved within the reference value from 5.3 to 5.1.

The present invention is not limited to the above-described embodiments, and it is obvious to those skilled in the art that various modifications and variations can be made without departing from the spirit and scope of the present invention. Accordingly, such modifications or variations should fall within the scope of the claims of the present invention.

Claims (7)

In a composition for oral administration for hydration and nutrition,
Contains glucose and glutathione as components,
The above glutathione is provided as L-glutathione yeast extract.
Contains additional vitamin C as a component,
It additionally contains taurine and refined salt as ingredients.
A skin whitening composition for oral administration further comprising orange juice powder, sodium citrate, orange flavor powder, DL-malic acid, enzymatically treated stevia, orange color SMP, sucralose, biotin mixture, vitamin B6 hydrochloride, vitamin B1 hydrochloride, hyaluronic acid mixture and vitamin B12 mixture as components,
The above oral skin whitening composition comprises 56.83 wt% of the glucose, 5 wt% of the taurine, 5 wt% of the glutathione, 3 wt% of the vitamin C, 1 wt% of the refined salt, 10 wt% of the orange juice powder, 10 wt% of the sodium citrate, 5 wt% of the orange flavor powder, 3 wt% of the DL-malic acid, 1 wt% of the enzyme-treated stevia, 0.1 wt% of the orange color SMP, 0.03 wt% of the sucralose, 0.01 wt% of the biotin mixture, 0.01 wt% of the vitamin B6 hydrochloride, 0.01 wt% of the vitamin B1 hydrochloride, 0.005 wt% of the hyaluronic acid mixture, and 0.005 wt% of the vitamin B12 mixture, based on the total weight of the composition.
delete delete delete delete delete In the first paragraph,
The above oral skin whitening composition
An oral skin whitening composition comprising glutathione, characterized in that it is manufactured in a powder form and is taken by the user by mixing it with an appropriate amount of water.