KR20230028614A - Hangover Relief and Functional Food Composition Containing Propolis - Google Patents

Abstract

The present invention relates to a hangover relieving and functional food composition, and more specifically, to a hangover relieving and functional food composition containing propolis, which has functions such as relieving hangover, enhancing immunity, and antioxidant effect by containing propolis, and can be configured as beverages or pills due to the change in wt% of a main component and the change in the composition of other compounds. A hangover relieving and functional food of the present invention comprises a propolis extract, prickly pear concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride, yeast extract powder, and other compounds.

Description

Hangover relief and functional food composition containing propolis {Hangover Relief and Functional Food Composition Containing Propolis}

The present invention relates to a hangover relieving and functional food composition, and more particularly, contains propolis and has functions such as relieving hangover, enhancing immunity, and antioxidant effect, but changing the weight % of the main component and the composition of other compounds, Or it relates to a hangover relief and functional food composition containing propolis consisting of a ring.

As sales of alcohol increase socially, the hangover cure market has been steadily increasing sales.

Due to the popularity of low-alcohol with fruit flavor, the liquor market for women is growing, and sales of alcoholic beverages are increasing due to social chaos and economic instability, and many pharmaceutical companies are actively conducting research and development of hangover cures.

Convenience stores in Korea, where trends change very quickly, are flooded with new products every day, but there is little change in hangover cures.

Although the packaging is different and the brand is different, products with old designs that are difficult to differentiate and taste like herbal medicines are generally distributed on the market.

In addition, existing hangover relievers contain unhealthy substances such as high-fructose fructose, caffeine, and preservatives, and products with unclear efficacy are continuously being released, increasing consumers' distrust of hangover relievers. .

Accordingly, the verification of efficacy has been completed, but there is an increasing demand from consumers for hangover relieving and functional foods that are not only effective for relieving hangovers but also helpful for health and have good taste and are easily accessible to the public.

(Patent Document 1) KR 10-1210748 B1

(Patent Document 2) KR 10-2021-0022849 A

The present invention was invented to improve the above problems, and propolis extract, prickly pear concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride, and yeast extract powder are used as main components, and changes in the weight percent of the main component and other compounds are used. Its purpose is to provide a hangover relief and functional food composition containing propolis, which can be provided in the form of a drink or pill, and which consumers can consume without objection through an improved popular taste.

The object of the present invention is not limited to the object mentioned above, and other objects not mentioned will be clearly understood from the description below.

A hangover relief and functional food composition containing propolis according to the present invention for achieving the above object is a main component and other compounds of propolis extract, cactus concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride and yeast extract powder. What has been done is a technical feature.

In addition, in the case of a beverage in which the main component is 1 to 2% by weight, the main component is 1 to 1.3% by weight of a propolis extract; Baeknyeoncho concentrate 0.1 to 0.5% by weight; 0.03 to 0.07% by weight of milk thistle extract; 0.05 to 0.15% by weight of vitamin C; 0.0001 to 0.0005% by weight of vitamin B1 hydrochloride; and 0.01 to 0.05% by weight of yeast extract powder; It is a technical feature that consists of.

In addition, when the main component is 28 to 30% by weight in the form of a ring, the main component is 0.3 to 0.5% by weight of a propolis extract; 8 to 9% by weight of Baeknyeoncho concentrate; 1.3 to 1.9% by weight of milk thistle extract; 1.5 to 2.5% by weight of vitamin C; 0.05 to 0.15% by weight of vitamin B1 hydrochloride; and 16 to 17% by weight of yeast extract powder; It is a technical feature that consists of.

In addition, when the hangover relief and functional food is in the form of a beverage, the other compounds include Hovenia dulcis extract powder, Hovenia dulcis fruit concentrate, rice germ soybean fermented mixed powder, goji berry concentrate, pear concentrate, sage honey, magnesium chloride, and vitamin B6 It is composed of hydrochloride, taurine, L-arginine, refined salt, white sugar, citric acid, trisodium citrate, green apple flavor, cyclodextrin, and purified water.

In addition, when the hangover relief and functional food is in the form of a ring, the other compounds include black bean powder, corn starch, crystalline cellulose, citrus peel powder, hydroxypropylmethylcellulose, turmeric extract powder, nicotinic acid amide, amino acid mixture, glycerin , It is characterized as being composed of vitamin B2.

The present invention according to the above configuration can expect the following effects.

It becomes possible to provide healthy food by excluding all of the liquid fructose, caffeine, and preservatives that existing hangover cures have.

It is possible to provide a hangover relief effect by using propolis extract, prickly pear concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride and yeast extract powder as main ingredients.

In addition, it contains flavonoids and vitamin C, which are one of the main components of propolis, so that it can be consumed as a health drink with antioxidant function, immunity enhancement, and antibacterial properties.

In general, by improving the taste of hangover cures made with the taste of herbal medicines to the taste of popular drinks, it is possible for consumers to consume them without feeling repulsive.

In addition, it can be produced in the form of a drink or a pill by changing the weight percent of the main component and the composition of other compounds, enabling consumers to select products for consumption.

1 is a graph showing a comparison of the alcohol measurement results of a control group administered with Alcohol alone and an experimental group administered with the present invention and Alcohol in combination.
Figure 2 is a graph showing the comparison of the Alcohol measurement results of the control group administered with Alcohol alone and the experimental group administered with the prior art and Alcohol in combination.
Figure 3 is a graph showing the comparison of the alcohol measurement results of the experimental group in which the present invention and Alcohol were co-administered and the experimental group in which the prior art and Alcohol were co-administered.
Figure 4 is a table showing the raw data of the biochemical analysis of the normal group in the alcohol degradation effect test.
Figure 5 is a table showing the biochemical analysis raw data of the experimental group in which the present invention and Alcohol were co-administered in the Alcohol decomposition effect test.
Figure 6 is a table showing the raw data of biochemical analysis of the experimental group in which the prior art and Alcohol were co-administered in the Alcohol decomposition effect test.
7 is a table showing the biochemical analysis raw data of the control group administered with Alcohol in the Alcohol decomposition effect test.

Hereinafter, a hangover relief and functional food composition containing propolis according to a preferred embodiment of the present invention will be described in detail with reference to the drawings.

Figure 1 is a graph showing the comparison of the alcohol measurement results of a control group administered with Alcohol alone and an experimental group administered with the present invention and Alcohol in combination, Figure 2 is a graph showing a comparison of the alcohol measurement results of a control group administered with Alcohol alone and an experimental group administered with conventional technology and Alcohol in combination A graph showing the comparison of measurement results, Figure 3 is a graph showing the comparison of the alcohol measurement results of the experimental group in which the present invention and Alcohol were co-administered, and the experimental group in which the conventional technology and Alcohol were co-administered, Figure 4 is the alcohol decomposition effect A table showing the raw data of biochemical analysis of the normal group in the sex experiment, Figure 5 is a table showing the raw data of biochemical analysis of the experimental group in which the present invention and Alcohol were co-administered in the alcohol degradation effect test, Figure 6 is the alcohol degradation effect A table showing the raw data of the biochemical analysis of the experimental group in which the conventional technique and Alcohol were co-administered in the experiment and FIG. 7 is a table showing the raw data of the biochemical analysis of the control group administered with Alcohol in the Alcohol decomposition effect experiment.

The hangover relief and functional food composition containing propolis according to a preferred embodiment of the present invention is a high-efficiency hangover relief food developed with propolis as the core, and contains flavonoids, honey, and vitamin C, which are one of the main constituents of propolis. can do.

The flavonoid component of propolis activates the SOD enzyme that suppresses harmful active oxygen in the body, so it can have excellent antioxidant action and help prevent vitamin C from being destroyed.

Propolis is rich in rutin, so it can have an effect on heart-related diseases and diabetes.

In detail, it contains 4 Di-Ocaffecyl Quinic acid-related substances contained in propolis extract, so it has excellent liver protection effect, lowers GPT level and protects damaged liver.

In addition, flavonoids, which are functional components of propolis, contain vitamin P as a central element, so they expand and strengthen capillaries, so they can have effects on cardiovascular disease and high blood pressure.

In addition, propolis is rich in various vitamins, minerals, amino acids, etc., so it may be possible to help improve health.

The above-mentioned propolis is a fat-soluble substance that is prone to deposition and is difficult to dissolve in water. It may be possible to help with taste and health aspects as well.

The hangover relief and functional food composition containing propolis according to a preferred embodiment of the present invention may be configured in the form of a drink or pill, and the form may be changed by changing the weight percent of the main component and other compounds.

First, the beverage form may be composed of the ingredients shown in Table 1.

Hangover relief and functional food composition containing propolis (drink form) No. Name of raw material or ingredient One propolis extract 2 Hovenia dulcis extract powder 3 Hovenia fruit concentrate 4 Rice Germ Soybean Fermented Mixed Powder 5 Goji berry concentrate 6 pear concentrate 7 Baeknyeoncho Concentrate 8 milk thistle extract 9 specification honey 10 magnesium chloride 11 vitamin C 12 Vitamin B1 hydrochloride 13 Vitamin B6 hydrochloride 14 yeast extract powder 15 taurine 16 L-Arginine 17 refined salt 18 white sugar 19 citric acid 20 trisodium citrate 21 Green apple flavor 22 cyclodextrin 23 Purified water

The beverage form of the present invention may be composed of a main ingredient and other compounds.

The main components may consist of propolis extract, prickly pear concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride and yeast extract powder.

Specifically, 1 to 1.3% by weight of propolis extract, 0.1 to 0.5% by weight of prickly pear concentrate, 0.03 to 0.07% by weight of milk thistle extract, 0.05 to 0.15% by weight of vitamin C, 0.0001 to 0.0005% by weight of vitamin B1 hydrochloride and yeast extract It may consist of 0.01 to 0.05% by weight of the powder.

Other compounds include 0.1 to 0.5% by weight of Hovenia dulcis extract powder, 1 to 2% by weight of Hovenia dulcis fruit concentrate, 0.005 to 0.015% by weight of fermented rice germ soybean powder, 0.1 to 0.5% by weight of goji berry concentrate, and 0.5 to 1.5% by weight of pear concentrate. 0.5 to 1.5% by weight of honey, 0.0005 to 0.0015% by weight of magnesium chloride, 0.0001 to 0.0005% by weight of vitamin B6 hydrochloride, 0.3 to 0.7% by weight of taurine, 0.5 to 1.5% by weight of L-arginine, 0.01 to 0.05% by weight of refined salt %, 6 to 10% by weight of white sugar, 0.5 to 0.9% by weight of citric acid, 0.03 to 0.07% by weight of trisodium citrate, 0.45 to 0.85% by weight of green apple flavor, 0.5 to 1.5% by weight of cyclodextrin, and 80 to 85% by weight of purified water. However, it may be preferable to be configured as shown in Table 2 below.

Hangover relief and functional food composition containing propolis (drink form) No. Name of raw material or ingredient weight% One propolis extract 1.15 2 Hovenia dulcis extract powder 0.3 3 Hovenia fruit concentrate 1.5 4 Rice Germ Soybean Fermented Mixed Powder 0.01 5 Goji berry concentrate 0.3 6 pear concentrate One 7 Baeknyeoncho Concentrate 0.3 8 milk thistle extract 0.05 9 specification honey One 10 magnesium chloride 0.001 11 vitamin C 0.1 12 Vitamin B1 hydrochloride 0.0003 13 Vitamin B6 hydrochloride 0.0003 14 yeast extract powder 0.03 15 taurine 0.5 16 L-Arginine One 17 refined salt 0.03 18 white sugar 8 19 citric acid 0.7 20 trisodium citrate 0.05 21 Green apple flavor 0.65 22 cyclodextrin One 23 Purified water 82.3284

The beverage form of the present invention is composed of propolis, one of the three natural antibiotics, and natural extracts such as barberry tree, honey, goji berry concentrate, and milk thistle as a core base. The tasting feeling is also improved by adding green apple flavor, etc., so that consumers can enjoy it deliciously without feeling repulsive.

Next, the ring form may be composed of the components shown in Table 3.

Hangover relief and functional food composition containing propolis (pill form) No. Name of raw material or ingredient One black bean powder 2 corn starch 3 yeast extract powder 4 crystalline cellulose 5 Citrus Peel Powder 6 Baeknyeoncho Concentrate 7 vitamin C 8 Hydroxypropylmethylcellulose 9 Turmeric Extract Powder 10 Milk Thistle Extract Powder 11 nicotinic acid amide 12 propolis extract 13 Amino acid mixture 14 glycerin 15 Vitamin B1 hydrochloride 16 Vitamin B2

The ring form of the present invention may be composed of the main component and other compounds.

The main components may consist of propolis extract, prickly pear concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride and yeast extract powder.

Specifically, 0.3 to 0.5% by weight of propolis extract, 8 to 9% by weight of prickly pear concentrate, 1.3 to 1.9% by weight of milk thistle extract, 1.5 to 2.5% by weight of vitamin C, 0.05 to 0.15% by weight of vitamin B1 hydrochloride and yeast extract It may consist of 16 to 17% by weight of the powder.

Other compounds include 22 to 26% by weight of black bean powder, 17 to 21% by weight of corn starch, 10 to 14% by weight of crystalline cellulose, 8 to 12% by weight of citrus peel powder, 1 to 3% by weight of hydroxypropylmethylcellulose, turmeric extract 1 to 2% by weight of powder, 0.5 to 1.5% by weight of nicotinamide, 0.1 to 0.5% by weight of amino acid mixture, 0.1 to 0.3% by weight of glycerin, and 0.05 to 0.15% by weight of vitamin B2, but as shown in Table 4 below It may be desirable to configure

Hangover relief and functional food composition containing propolis (pill form) No. Name of raw material or ingredient weight% One black bean powder 24 2 corn starch 19.465 3 yeast extract powder 16.667 4 crystalline cellulose 12 5 Citrus Peel Powder 10 6 Baeknyeoncho Concentrate 8.334 7 vitamin C 2 8 Hydroxypropylmethylcellulose 2 9 Turmeric Extract Powder 1.667 10 Milk Thistle Extract Powder 1.667 11 nicotinic acid amide One 12 propolis extract 0.5 13 Amino acid mixture 0.3 14 glycerin 0.2 15 Vitamin B1 hydrochloride 0.1 16 Vitamin B2 0.1

Hereinafter, the alcohol decomposition effect of the present invention through the experimental results will be described in more detail.

After separating 18 6-week-old Wistar males into 1 cage per 3 animals, they were acclimated for 8 days, and the test was conducted according to the criteria according to Table 5 below.

temperature 23±2℃ humidity 55±5% ventilation frequency 13 times/hour drunk Ammonia concentration should not exceed 20ppm light 150~300 Lux (based on 40 ~ 80 cm from the ground) noise not exceed 60 db

On the 7th day of acclimatization, the weight was measured to equalize the average weight of each group, and divided into 3 groups: 6 normal group, 6 experimental group (Alcohol administration group after administration of the present invention), and 6 control group (Alcohol only administration). , fasted for 16 hours and allowed free access to water.

The experimental group was orally administered with the present invention at a dose of 10ml/kg, and 40% alcohol was orally administered at a dose of 10ml/kg to rats in the experimental and control groups 30 minutes after administration.

After 5 hours of alcohol administration, the normal group, the experimental group and the control group were anesthetized and cardiac blood was collected for examination.

In addition, comparison with the conventional technique was also experimented, and all biochemical analysis raw data can be found in FIGS. 4, 5, 6 and 7.

<Experiment Result 1> Comparative evaluation of the normal group and the experimental group

1) Evaluation of hepatocellular leaky enzyme AST, ALT

There was no significant difference in both AST and ALT between the normal and experimental groups.

2) Evaluation of cholestasis-inducing enzymes ALP and GGT

There was no significant difference between ALP and GGT between normal and experimental groups.

3) Assessment of liver synthesis capacity factors Protein, Albumin and Glucose

There was no significant difference in both Albumin and Glucose between the normal group and the experimental group.

However, Protein showed significantly lower results in the experimental group (4.93±0.26mg/dL) than in the normal group (5.23±0.25mg/dL).

4) Evaluation of total cholesterol

Total cholesterol did not show a significant difference between the normal group and the experimental group.

5) Evaluation of kidney function Creatinine, BUN

Creatinine and BUN did not show significant differences between normal and experimental groups.

6) Alcohol decomposition effect evaluation

It was not detected in the normal group and was measured at 121.18±22.12mg/dL in the experimental group.

<Experiment 2> Comparative evaluation of normal group and control group

1) Evaluation of hepatocellular leaky enzyme AST, ALT

There was no significant difference in both AST and ALT between the normal group and the control group.

2) Evaluation of cholestasis-inducing enzymes ALP and GGT

There was no significant difference between ALP and GGT between the normal group and the control group.

3) Assessment of liver synthesis capacity factors Protein, Albumin and Glucose

There was no significant difference in protein and albumin between the normal group and the control group, but glucose was lower in the control group (78.22 ± 14.32 mg/dL) than in the normal group (102.93 ± 9.67 mg/dL).

4) Evaluation of total cholesterol

Total cholesterol did not show a significant difference between normal and control groups.

5) Evaluation of kidney function Creatinine, BUN

Creatinine showed no significant difference between the normal group and the control group, and BUN showed a significantly higher result in the control group (14.45 ± 4.00 mg/dL) than the normal group (10.35 ± 1.12 mg/dL).

6) Alcohol decomposition effect evaluation

It was not detected in the normal group, and it was measured as 165.97±26.62mg/dL in the control group, confirming the increase in blood due to Alcohol administration.

<Experiment Result 3> Comparative evaluation of biochemical changes and alcohol metabolism in the experimental group and the control group

There were no significant differences in Protein, Albumin, AST, ALT, Creatinine and Cholesterol between the experimental group and the control group.

BUN showed significantly lower results in the experimental group (10.66±3.31mg/dL) than in the control group (14.45±4.00mg/dL).

GGT showed significantly lower results in the experimental group (1.37±0.12 U/L) than in the control group (1.45±0.12 U/L).

Glucose showed significantly higher results in the experimental group (118.65±17.00mg/dL) than in the control group (78.72±14.32mg/dL).

Alcohol measurement results were lower in the experimental group (121.18 ± 22.12mg / dL) than in the control group (165.97 ± 26.62mg / dL), confirming the alcohol reduction effect due to the present invention.

<Experiment 4> Comparative evaluation of the present invention and conventional technology

There was a significant difference in alcohol decomposition effect between the experimental group of the present invention + 40% Alcohol combined administration and the conventional technique + 40% Alcohol combined administration experimental group, and the present invention + 40% Alcohol combined administration experimental group showed a higher alcohol degradation effect gave.

The above embodiment is merely an example, and other embodiments variously modified therefrom are possible to those skilled in the art.

Therefore, the true technical protection scope of the present invention should include not only the above embodiments but also variously modified other embodiments according to the technical spirit of the invention described in the claims below.

Claims (5)

In hangover relief and functional foods,
Propolis extract, prickly pear concentrate, milk thistle extract, vitamin C, vitamin B1 hydrochloride and yeast extract powder as main components and other compounds containing propolis to relieve hangover and functional food composition. The method of claim 1,
In the case of a beverage form in which the main component is 1 to 2% by weight,
The main component is 1 to 1.3% by weight of a propolis extract;
Baeknyeoncho concentrate 0.1 to 0.5% by weight;
0.03 to 0.07% by weight of milk thistle extract;
0.05 to 0.15% by weight of vitamin C;
0.0001 to 0.0005% by weight of vitamin B1 hydrochloride; and
Yeast extract powder 0.01 to 0.05% by weight; Hangover relief and functional food composition containing propolis, characterized in that consisting of. The method of claim 1,
In the case of a ring form in which the main component is 28 to 30% by weight,
The main component is 0.3 to 0.5% by weight of a propolis extract;
8 to 9% by weight of Baeknyeoncho concentrate;
1.3 to 1.9% by weight of milk thistle extract;
1.5 to 2.5% by weight of vitamin C;
0.05 to 0.15% by weight of vitamin B1 hydrochloride; and
16 to 17% by weight of yeast extract powder; Hangover relief and functional food composition containing propolis, characterized in that consisting of. According to claim 2,
The other compounds are Hovenia dulcis extract powder, Hovenia dulcis fruit concentrate, rice germ soybean fermented mixed powder, goji berry concentrate, pear concentrate, fermented honey, magnesium chloride, vitamin B6 hydrochloride, taurine, L-arginine, refined salt, white sugar, A hangover relief and functional food composition containing propolis, characterized in that it consists of citric acid, trisodium citrate, green apple flavor, cyclodextrin and purified water. According to claim 3,
The other compounds are black bean powder, corn starch, crystalline cellulose, citrus peel powder, hydroxypropylmethylcellulose, turmeric extract powder, nicotinic acid amide, amino acid mixture, glycerin, and vitamin B2. Hangover relief and functional food composition.

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