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KR840007409A - 복소환 또는 치환에 의해 6위치에 치환된 아미드화 피리다진 유도체의 제조방법 - Google Patents

복소환 또는 치환에 의해 6위치에 치환된 아미드화 피리다진 유도체의 제조방법 Download PDF

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Publication number
KR840007409A
KR840007409A KR1019840000274A KR840000274A KR840007409A KR 840007409 A KR840007409 A KR 840007409A KR 1019840000274 A KR1019840000274 A KR 1019840000274A KR 840000274 A KR840000274 A KR 840000274A KR 840007409 A KR840007409 A KR 840007409A
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South Korea
Prior art keywords
amine
pyridazine
chlorinated derivative
thienyl
methyl
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KR1019840000274A
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KR910000641B1 (ko
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2) 쟝-뽈깡(외
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미쉘드 아스
소시에떼 아노님 사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음.

Description

복소환 또는 치환에 의해 6위치에 치환된 아미드화 피리다진 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식1의 염소화 유도체를 알콜과 같은 용매에서 수소산수용체 존재하고 온에서 하기 일반식2의 아민과 반응시키고, 필요하다면 수득된 유도체를 약학적으로 수용할 수 있는 염으로 전환시킴을 특징으로 하는 하기 일반식(I)의 아미드화 피리다진 유도체 및 그의 산부가염의 제조방법.
  3. (상기식중, R1은 2-티에닐, 3-티에닐 또는 시클로헥실기를 나타내고, R2는 저급 알킬기(1~4탄소원자) 또는 수소원자를 나타낸다.)
  4. 제1항에 있어서, 염소화 유도체가 케톤 R1-CO-CH3와 α-케토산 R2-CO-COOH를 축합하고, 수득된 α-히드록시 감마 케톤산을 히드라진 NH2-NH2와 반응시켜 상응하는 3-피리다존을 수득한 후, 이를 포스포리스 옥시클로라이드와 반응시킴으로써 수득됨을 특징으로 하는 방법.
  5. 제1항에 있어서, 염소화 유도체가 3클로로 4-메틸 6-(2-티에닐)피리다진이고 아민이 2-모르폴리노에틸아민인 방법.
  6. 제1항에 있어서, 염소화 유도체가 3-클로로 4-메틸 6-(3-티에닐) 피리다진이고 아민이 2-모르폴리노에틸 아민인 방법.
  7. 제1항에 있어서, 염소화 유도체가 3-클로로 4-메틸 6-시클로헥실 피리다진이고 아민이 2-모르폴리노에틸 아민인 방법.
  8. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000274A 1983-01-24 1984-01-23 복소환 또는 치환에 의해 6위치에 치환된 아미노화 피리다진 유도체의 제조방법 Expired KR910000641B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8301029 1983-01-24
FR8301029A FR2539742B1 (fr) 1983-01-24 1983-01-24 Derives amines de la pyridazine substitues en position 6 par un heterocycle ou un alicycle, lesdits derives etant actifs sur le systeme nerveux central

Publications (2)

Publication Number Publication Date
KR840007409A true KR840007409A (ko) 1984-12-07
KR910000641B1 KR910000641B1 (ko) 1991-01-31

Family

ID=9285222

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000274A Expired KR910000641B1 (ko) 1983-01-24 1984-01-23 복소환 또는 치환에 의해 6위치에 치환된 아미노화 피리다진 유도체의 제조방법

Country Status (24)

Country Link
US (1) US4524070A (ko)
EP (1) EP0117171B1 (ko)
JP (1) JPS59139367A (ko)
KR (1) KR910000641B1 (ko)
AT (1) ATE28077T1 (ko)
AU (1) AU560542B2 (ko)
CA (1) CA1218063A (ko)
CS (1) CS241539B2 (ko)
DD (1) DD238793A5 (ko)
DE (1) DE3464491D1 (ko)
DK (1) DK31584A (ko)
ES (1) ES529007A0 (ko)
FI (1) FI840268A7 (ko)
FR (1) FR2539742B1 (ko)
GR (1) GR81717B (ko)
HU (1) HU192390B (ko)
IE (1) IE840150L (ko)
IL (1) IL70757A (ko)
NO (1) NO840244L (ko)
NZ (1) NZ206907A (ko)
PT (1) PT77982B (ko)
SU (1) SU1189345A3 (ko)
YU (1) YU12384A (ko)
ZA (1) ZA84501B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2269788A (en) * 1987-08-19 1989-03-09 Erich-Klaus Martin Process for purifying and regenerating used oils
US5461053A (en) * 1989-02-07 1995-10-24 Sanofi Pyridazine derivatives
US5631255A (en) * 1989-02-07 1997-05-20 Sanofi Pyridazine derivatives
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
US8338591B2 (en) * 2004-05-08 2012-12-25 Novartis International Pharmaceutical Ltd. 3-aryl-5,6-disubstituted pyridazines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1292443A (en) * 1968-11-01 1972-10-11 Ct D Etudes Experimentales Et New pyridazine derivatives and process for their preparation
GB1345880A (en) * 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives

Also Published As

Publication number Publication date
DD238793A5 (de) 1986-09-03
DK31584D0 (da) 1984-01-24
FI840268A0 (fi) 1984-01-23
PT77982A (fr) 1984-02-01
GR81717B (ko) 1984-12-12
EP0117171A1 (fr) 1984-08-29
FR2539742B1 (fr) 1986-09-05
PT77982B (fr) 1986-04-10
YU12384A (en) 1986-10-31
US4524070A (en) 1985-06-18
DK31584A (da) 1984-07-25
ATE28077T1 (de) 1987-07-15
SU1189345A3 (ru) 1985-10-30
EP0117171B1 (fr) 1987-07-01
IL70757A0 (en) 1984-04-30
KR910000641B1 (ko) 1991-01-31
CA1218063A (en) 1987-02-17
ZA84501B (en) 1984-09-26
FI840268A7 (fi) 1984-07-25
HU192390B (en) 1987-06-29
JPS59139367A (ja) 1984-08-10
AU560542B2 (en) 1987-04-09
CS241539B2 (en) 1986-03-13
ES8407043A1 (es) 1984-09-01
IL70757A (en) 1986-12-31
NZ206907A (en) 1987-03-31
DE3464491D1 (en) 1987-08-06
ES529007A0 (es) 1984-09-01
CS53084A2 (en) 1985-07-16
IE840150L (en) 1984-07-24
FR2539742A1 (fr) 1984-07-27
AU2372784A (en) 1984-07-26
NO840244L (no) 1984-07-25

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