LTC2922872I2 - - Google Patents
Info
- Publication number
- LTC2922872I2 LTC2922872I2 LTPA2022507C LTPA2022507C LTC2922872I2 LT C2922872 I2 LTC2922872 I2 LT C2922872I2 LT PA2022507 C LTPA2022507 C LT PA2022507C LT PA2022507 C LTPA2022507 C LT PA2022507C LT C2922872 I2 LTC2922872 I2 LT C2922872I2
- Authority
- LT
- Lithuania
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728912P | 2012-11-21 | 2012-11-21 | |
| US201361782550P | 2013-03-14 | 2013-03-14 | |
| US201361809541P | 2013-04-08 | 2013-04-08 | |
| US201361864717P | 2013-08-12 | 2013-08-12 | |
| US201361892797P | 2013-10-18 | 2013-10-18 | |
| PCT/US2013/071288 WO2014081954A1 (en) | 2012-11-21 | 2013-11-21 | BISPECIFIC EGFR/c-Met ANTIBODIES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTPA2022507I1 LTPA2022507I1 (en) | 2022-06-27 |
| LTC2922872I2 true LTC2922872I2 (en) | 2024-09-10 |
Family
ID=50728148
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP18199421.1T LT3447069T (en) | 2012-11-21 | 2013-11-21 | BIS-SPECIFIC EGFR / C-MET ANTIBODIES |
| LTEP13856592.4T LT2922872T (en) | 2012-11-21 | 2013-11-21 | Bispecific egfr/c-met antibodies |
| LTPA2022507C LTC2922872I2 (en) | 2012-11-21 | 2022-06-06 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP18199421.1T LT3447069T (en) | 2012-11-21 | 2013-11-21 | BIS-SPECIFIC EGFR / C-MET ANTIBODIES |
| LTEP13856592.4T LT2922872T (en) | 2012-11-21 | 2013-11-21 | Bispecific egfr/c-met antibodies |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US9593164B2 (en) |
| EP (4) | EP3808767B1 (en) |
| JP (5) | JP6423357B2 (en) |
| KR (4) | KR20220032654A (en) |
| CN (2) | CN113201073A (en) |
| AU (4) | AU2013347962B2 (en) |
| BR (1) | BR112015011717B1 (en) |
| CA (2) | CA2893505C (en) |
| CL (1) | CL2015001356A1 (en) |
| CY (2) | CY1121270T1 (en) |
| DK (2) | DK2922872T3 (en) |
| EA (1) | EA031184B1 (en) |
| ES (3) | ES2700231T3 (en) |
| FI (1) | FIC20220016I1 (en) |
| FR (1) | FR22C1018I2 (en) |
| HR (2) | HRP20182128T1 (en) |
| HU (3) | HUE041499T2 (en) |
| IL (1) | IL238796B (en) |
| LT (3) | LT3447069T (en) |
| LU (1) | LUC00257I2 (en) |
| MX (1) | MX361088B (en) |
| NI (1) | NI201500069A (en) |
| NL (1) | NL301173I2 (en) |
| NO (1) | NO2022012I1 (en) |
| NZ (1) | NZ708352A (en) |
| PE (1) | PE20151181A1 (en) |
| PH (1) | PH12015501118A1 (en) |
| PL (1) | PL2922872T3 (en) |
| PT (2) | PT3447069T (en) |
| RS (2) | RS58192B1 (en) |
| SG (1) | SG11201503938VA (en) |
| SI (2) | SI3447069T1 (en) |
| SM (2) | SMT201800624T1 (en) |
| UA (1) | UA117121C2 (en) |
| WO (1) | WO2014081954A1 (en) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101802015B (en) | 2007-03-29 | 2015-05-06 | 根马布股份公司 | Bispecific antibody and its production method |
| ES2751549T3 (en) * | 2009-11-30 | 2020-04-01 | Janssen Biotech Inc | Fc antibody mutants with ablated effector functions |
| US9068011B2 (en) | 2010-03-10 | 2015-06-30 | Genmab A+S | Monoclonal antibodies against c-Met |
| DK2560993T3 (en) | 2010-04-20 | 2024-10-14 | Genmab As | HETERODIMERIC ANTIBODY FC-CONTAINING PROTEINS AND METHODS FOR PRODUCTION THEREOF |
| CN107253992B (en) | 2010-05-27 | 2022-03-11 | 根马布股份公司 | Monoclonal antibody against HER2 |
| AU2012328322A1 (en) | 2011-10-27 | 2014-06-12 | Genmab A/S | Production of heterodimeric proteins |
| US9695228B2 (en) * | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| CN113201073A (en) * | 2012-11-21 | 2021-08-03 | 詹森生物科技公司 | Bispecific EGFR/c-Met antibodies |
| US20170275367A1 (en) | 2012-11-21 | 2017-09-28 | Janssen Biotech, Inc. | Bispecific EGFR/C-Met Antibodies |
| WO2015057545A2 (en) | 2013-10-14 | 2015-04-23 | Janssen Biotech, Inc. | Cysteine engineered fibronectin type iii domain binding molecules |
| BR112016017897A8 (en) * | 2014-02-04 | 2020-06-30 | Astellas Pharma Inc | use of heterocyclic diamino carboxamide compound in the treatment of axl-related cancer, pharmaceutical composition and combination |
| US10844127B2 (en) | 2014-02-28 | 2020-11-24 | Merus N.V. | Antibodies that bind EGFR and ErbB3 |
| KR102309881B1 (en) | 2014-11-21 | 2021-10-06 | 삼성전자주식회사 | Pharmaceutical composition for combination therapy containing dual inhibitor of c-Met and EGFR and IGF-1R inhibitor |
| JP6769962B2 (en) * | 2014-12-03 | 2020-10-14 | オークランド ユニサービシーズ リミティド | Kinase inhibitor prodrugs for cancer treatment |
| EP3234120B1 (en) | 2014-12-15 | 2025-09-03 | The Regents of the University of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| US11253546B2 (en) | 2014-12-15 | 2022-02-22 | The Regents Of The University Of California | Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20 |
| WO2016097300A1 (en) | 2014-12-19 | 2016-06-23 | Genmab A/S | Rodent bispecific heterodimeric proteins |
| DK3237005T3 (en) * | 2014-12-22 | 2024-11-18 | Systimmune Inc | Bispecific tetravalent antibodies and methods of making and using thereof |
| GB201506870D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method |
| WO2016182513A1 (en) * | 2015-05-13 | 2016-11-17 | Singapore Health Services Pte Ltd | Profiling of hepatocellular carcinoma and applications thereof |
| RS61800B1 (en) | 2015-10-23 | 2021-06-30 | Merus Nv | Binding molecules that inhibit cancer growth |
| WO2017076492A1 (en) * | 2015-11-03 | 2017-05-11 | Merck Patent Gmbh | Bi-specific antibodies for enhanced tumor selectivity and inhibition and uses thereof |
| MA43186B1 (en) | 2015-11-03 | 2022-03-31 | Janssen Biotech Inc | Antibodies specifically binding to pd-1 and uses thereof |
| TWI738713B (en) * | 2016-02-06 | 2021-09-11 | 開曼群島商岸邁生物科技有限公司 | Fabs-in-tandem immunoglobulin and uses thereof |
| RU2751341C2 (en) | 2016-05-26 | 2021-07-13 | РЕКЬЮРИУМ АйПи ХОЛДИНГС, ЛЛС | Egfr inhibitor compounds |
| KR101985299B1 (en) * | 2016-06-03 | 2019-09-03 | 삼성전자주식회사 | Anti-c-Met/anti-Nrp1 bispecific antibody |
| MX2018016185A (en) * | 2016-06-21 | 2019-03-28 | Janssen Biotech Inc | Cysteine engineered fibronectin type iii domain binding molecules. |
| WO2018042385A2 (en) | 2016-09-02 | 2018-03-08 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| TWI782930B (en) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | Anti-met antibodies, bispecific antigen binding molecules that bind met, and methods of use thereof |
| CN110177571B (en) | 2016-11-18 | 2024-05-24 | 加利福尼亚大学董事会 | Engineered antibodies and their uses |
| BR112019012154A2 (en) | 2016-12-14 | 2019-11-12 | Janssen Biotech Inc | cd8a-binding fibronectin type iii domains |
| WO2018111978A1 (en) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
| WO2018145048A1 (en) * | 2017-02-06 | 2018-08-09 | Academia Sinica | Recombinant proteins and uses thereof |
| EA201992063A1 (en) | 2017-03-31 | 2020-03-26 | Мерус Н.В. | BINDING ErbB-2 AND ErbB-3 SPECIFIC ANTIBODIES FOR USE FOR TREATMENT OF CELLS THAT CONTAIN THE NRG-1 FUSED GENE |
| WO2018212656A1 (en) | 2017-05-17 | 2018-11-22 | Merus N.V. | Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer |
| WO2018221969A1 (en) * | 2017-05-30 | 2018-12-06 | Chong Kun Dang Pharmaceutical Corp. | A novel anti-c-met antibody and use thereof |
| KR102078292B1 (en) * | 2017-05-30 | 2020-02-19 | 주식회사 종근당 | A novel anti c-Met antibody and use thereof |
| HUE071182T2 (en) * | 2017-08-09 | 2025-08-28 | Merus Nv | EGFR and CMET binding antibodies |
| US11078263B2 (en) * | 2017-08-25 | 2021-08-03 | Janssen Biotech, Inc. | Fc γ RIII binding fibronectin type III domains, their conjugates and multispecific molecules comprising them |
| WO2019114793A1 (en) * | 2017-12-13 | 2019-06-20 | 凯惠科技发展(上海)有限公司 | Egfr antibody, preparation method therefor and application thereof |
| US20190184028A1 (en) * | 2017-12-14 | 2019-06-20 | Janssen Biotech, Inc. | Targeting with firbronectin type iii like domain molecules |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| MA52777A (en) | 2018-05-24 | 2021-04-14 | Janssen Biotech Inc | PSMA LIAISON OFFICERS AND CORRESPONDING USES |
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| WO2020055761A1 (en) * | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| MX2021002805A (en) | 2018-09-10 | 2021-07-15 | Mirati Therapeutics Inc | Combination therapies. |
| JP7539902B2 (en) | 2018-10-22 | 2024-08-26 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Glucagon-like peptide 1 (GLP1)-growth differentiation factor 15 (GDF15) fusion protein and uses thereof |
| MX2021002804A (en) | 2018-12-05 | 2021-07-15 | Mirati Therapeutics Inc | Combination therapies. |
| TWI874341B (en) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | Methods of producing heterodimeric antibodies |
| AU2020229467A1 (en) * | 2019-02-26 | 2021-08-12 | Janssen Biotech, Inc. | Combination therapies and patient stratification with bispecific anti-EGFR/c-met antibodies |
| MA55717A (en) | 2019-04-19 | 2022-02-23 | Janssen Biotech Inc | METHODS OF TREATMENT OF PROSTATE CANCER WITH ANTI-PSMA/CD3 ANTIBODY |
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| JOP20210304A1 (en) * | 2019-05-14 | 2023-01-30 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| KR20220063185A (en) | 2019-09-16 | 2022-05-17 | 리제너론 파마슈티칼스 인코포레이티드 | Radiolabeled MET binding protein for immuno-PET imaging |
| EP4045061A4 (en) | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | CD71-BINDING FIBRONECTIN TYPE III DOMAINS |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| JOP20220184A1 (en) * | 2020-02-12 | 2023-01-30 | Janssen Biotech Inc | TREATMENT OF PATIENTS HAVING c-MET EXON 14 SKIPPING MUTATIONS |
| TW202207940A (en) | 2020-04-14 | 2022-03-01 | 美商健生生物科技公司 | Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof |
| KR20230053686A (en) * | 2020-08-25 | 2023-04-21 | 얀센 바이오테크 인코포레이티드 | Treatment of non-small cell lung cancer with EGFR mutations |
| AR123340A1 (en) * | 2020-08-26 | 2022-11-23 | Janssen Biotech Inc | STABLE FORMULATIONS COMPRISING A BISECFIC ANTIBODY TO EGFR/c-MET |
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