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PE20030137A1 - Derivados antimicrobianos de quinolona - Google Patents

Derivados antimicrobianos de quinolona

Info

Publication number
PE20030137A1
PE20030137A1 PE2001001284A PE2001001284A PE20030137A1 PE 20030137 A1 PE20030137 A1 PE 20030137A1 PE 2001001284 A PE2001001284 A PE 2001001284A PE 2001001284 A PE2001001284 A PE 2001001284A PE 20030137 A1 PE20030137 A1 PE 20030137A1
Authority
PE
Peru
Prior art keywords
alkyl
quinolone
ona
carboxi
alcoxy
Prior art date
Application number
PE2001001284A
Other languages
English (en)
Inventor
Mikhail Gordeev
Michael R Barbachyn
Dinesh V Patel
James R Gage
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20030137A1 publication Critical patent/PE20030137A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UNA QUINOLONA DE FORMULA I DONDE Y1 ES CH, N; Y2, Y3, Y4 SON C Y N; L ES UNA UNION O UN ENLACE HACIA UN CARBONO EN LA POSICION SIETE DEL ANILLO DE QUINOLONA O UN N EN LA POSICION UNO DEL ANILLO DE QUINOLONA; m ES 0-1; n ES 0-3; Q ES EL GRUPO a, GRUPO b, ENTRE OTROS. R1 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C5, HALOALQUILO C1-C4, ENTRE OTROS; R2 ES NULO CUANDO Y2 ES N, H, ALQUILO, ALCOXI C1-C2, ENTRE OTROS; R3 ES H, F CUANDO Y2 ES C, O R3 ES NULO CUANDO Y3 ES N; R4 ES H, CH3, AMINO, F; R5 ES H, CH3, OH, HALO; R6 ES H, CH3, OH, HALO; R7 ES H, ALQUILO C1-C4, ENTRE OTROS; R8 ES H, ALQUILO C1-C4, ENTRE OTROS; R9 ES ES H, ALQUILO C1-C4, ENTRE OTROS; R10 ES OH, ALCOXI, ARILOXI, NHC(=Z)R11, ENTRE OTROS. SON COMPUESTOS PREFERIDO 7-[4-[(5-(S)-ACETAMIDOMETILOXAZOLIDINA-2-ONA-3-IL)-2-FLUOROFENIL]PIPERAZINA-1-IL]-3-CARBOXI-1-CICLOPROPIL-6-FLUORO-1,4-DIHIDROQUINOLA-4-ONA, 10-[4-[(5-(S)-ACETAMIDOMETILOXAZOLIDINA-2-ONA-3-IL)-2-FLUOROFENIL]PIPERAZINA-1-IL]-6-CARBOXI-9-FLUORO-2,3-DIHIDRO-3-METIL-7-OXO-7H-PIRIDO-[1,2,3-d]-1,4-BENZOXAZINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON DERIVADOS DE QUINOLONA Y SON UTILES COMO AGENTES ANTIBACTERIANOS
PE2001001284A 2000-12-21 2001-12-20 Derivados antimicrobianos de quinolona PE20030137A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25790400P 2000-12-21 2000-12-21

Publications (1)

Publication Number Publication Date
PE20030137A1 true PE20030137A1 (es) 2003-03-08

Family

ID=22978270

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001284A PE20030137A1 (es) 2000-12-21 2001-12-20 Derivados antimicrobianos de quinolona

Country Status (9)

Country Link
US (2) US6689769B2 (es)
EP (1) EP1349853B1 (es)
JP (1) JP2004518677A (es)
AT (1) ATE319710T1 (es)
CA (1) CA2424402A1 (es)
DE (1) DE60117861T2 (es)
ES (1) ES2256331T3 (es)
PE (1) PE20030137A1 (es)
WO (1) WO2002059116A2 (es)

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DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
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US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
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US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
EP2028936A4 (en) * 2006-02-13 2014-02-26 Univ Boston COMPOSITIONS AND METHODS FOR ANTIBIOTIC REINFORCEMENT AND ACTIVE INFLUENCE
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
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DK2296651T3 (da) * 2008-05-09 2012-09-24 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-on-derivater til behandling af bakterielle intestinale sygdomme
KR100980681B1 (ko) 2008-09-16 2010-09-07 한국과학기술연구원 디플루오로페닐 유도체를 갖는 신규한 옥사졸리디논 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 항생제 조성물
EP2344129B1 (en) 2008-10-07 2018-02-21 Horizon Orphan LLC Aerosol fluoroquinolone formulations for improved pharmacokinetics
SI2346509T1 (sl) 2008-10-07 2020-08-31 Horizon Orphan Llc Inhalacija levofloksacina za zmanjšanje vnetja pljuč
NZ598484A (en) 2009-09-04 2014-02-28 Mpex Pharmaceuticals Inc Use of aerosolized levofloxacin for treating cystic fibrosis
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Also Published As

Publication number Publication date
US6869965B2 (en) 2005-03-22
DE60117861D1 (de) 2006-05-04
US6689769B2 (en) 2004-02-10
JP2004518677A (ja) 2004-06-24
DE60117861T2 (de) 2006-11-02
ATE319710T1 (de) 2006-03-15
WO2002059116A2 (en) 2002-08-01
US20030013737A1 (en) 2003-01-16
WO2002059116A3 (en) 2002-12-05
CA2424402A1 (en) 2002-08-01
EP1349853B1 (en) 2006-03-08
US20040215017A1 (en) 2004-10-28
ES2256331T3 (es) 2006-07-16
EP1349853A2 (en) 2003-10-08

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