PE20030337A1 - Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos - Google Patents
Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentosInfo
- Publication number
- PE20030337A1 PE20030337A1 PE2002000809A PE2002000809A PE20030337A1 PE 20030337 A1 PE20030337 A1 PE 20030337A1 PE 2002000809 A PE2002000809 A PE 2002000809A PE 2002000809 A PE2002000809 A PE 2002000809A PE 20030337 A1 PE20030337 A1 PE 20030337A1
- Authority
- PE
- Peru
- Prior art keywords
- derivatives
- preparation
- indan
- onas
- medicines
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- QNXSIUBBGPHDDE-UHFFFAOYSA-N indan-1-one Chemical class C1=CC=C2C(=O)CCC2=C1 QNXSIUBBGPHDDE-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A INDAN-1-ONA SUSTITUIDA EN C2 DE FORMULA I DONDE R1, R2, R3, R4 SON H, F, Cl, Br, I, CN, N3, NO2, OH, O-ALQUILO C1-C8, O-CICLOALQUILO C3-C8, O-CH2-FENILO, O-FENILO, ENTRE OTROS; X ES S, SO, SO2; Y ES (CH2)p; p ES 0-3; R5 ES CF3, ALQUILO C1-C18, CICLOALQUILO C3-C4, (CH2)rCOR6, CH2-CH(NHR7)-COR8, FENILO, NAFTILO, BIFENILO, HETEROCICLO, r ES 1-6; R6 ES OH, O-ALQUILO C1-C6, NH2; R7 ES H, CO-ALQUILO C1-C4; R8 ES OH, O-ALQUILO C1-C6, NH2, R9 ES F, Cl, Br, CN, CF3, ALQUILO C1-C18, CICLOALQUILO C3-C4, (CH2)rCOR6, r ES 9-16. EXCEPTO LOS COMPUESTOS I CUANDO R1, R2, R3, R4 SON H; X-Y-R5 ES FENILO; R9 ES FENILO. SON COMPUESTOS PREFERIDOS 5-CLORO-2-FLUORO-2-METANOSULFONIL-INDAN-1-ONA; 2-BENCIL5-CLORO-2-METANOSULFONIL-INDAN-1-ONA. TAMBIEN SE REFIERE A UN PROCESO PARA LA RPEPARACION. LOS COMPUESTOS SON ANOREXICOS, TIENEN EFECTO SOBRE EL METABOLISMO DE GRASAS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE OBESIDAD, DIABETES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10142665A DE10142665B4 (de) | 2001-08-31 | 2001-08-31 | C2-Disubstituierte Indan-1-one und ihre Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030337A1 true PE20030337A1 (es) | 2003-05-22 |
Family
ID=7697235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000809A PE20030337A1 (es) | 2001-08-31 | 2002-08-23 | Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7081467B2 (es) |
| EP (1) | EP1423359B1 (es) |
| JP (1) | JP4250079B2 (es) |
| AT (1) | ATE473962T1 (es) |
| AU (1) | AU2002336983B2 (es) |
| CA (1) | CA2458524C (es) |
| DE (2) | DE10142665B4 (es) |
| IL (1) | IL160604A0 (es) |
| MX (1) | MXPA04001851A (es) |
| PE (1) | PE20030337A1 (es) |
| WO (1) | WO2003020697A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2880887B1 (fr) * | 2005-01-14 | 2009-01-30 | Merck Sante Soc Par Actions Si | Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
| CN112574078B (zh) * | 2020-12-14 | 2022-09-13 | 湖南工程学院 | 2-砜基-2，3-二氢-1-茚酮及其衍生物及合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS516724A (en) * | 1974-07-06 | 1976-01-20 | Konishiroku Photo Ind | Harogenkaginshashinkankozairyo |
| SE7700500L (sv) * | 1976-01-20 | 1977-07-21 | Hoechst Ag | Tiazolidinderivat och forfarande for deras framstellning |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| US5232940A (en) | 1985-12-20 | 1993-08-03 | Hatton Leslie R | Derivatives of N-phenylpyrazoles |
| GB8531485D0 (en) | 1985-12-20 | 1986-02-05 | May & Baker Ltd | Compositions of matter |
| GB8713768D0 (en) | 1987-06-12 | 1987-07-15 | May & Baker Ltd | Compositions of matter |
| KR0170567B1 (ko) | 1992-12-17 | 1999-02-18 | 알렌 제이. 스피겔 | 부신피질자극호르몬-유리 인자 길항물질 활성을 갖는 피라졸 및 피라졸로피리미딘 |
| CA2239853C (en) | 1995-12-06 | 2006-11-28 | Venantius Limited | Indane dimer compounds and their pharmaceutical use |
| KR19990077319A (ko) | 1996-01-17 | 1999-10-25 | 한센 핀 베네드, 안네 제헤르 | 축합된 1,2,4-티아디아진 및 축합된 1,4-티아진 유도체, 그것의제조방법 및 사용 |
| GB9604691D0 (en) | 1996-03-05 | 1996-05-01 | Rhone Poulenc Agriculture | New processes for preparing pesticidal intermediates |
| ATE356830T1 (de) | 1996-08-30 | 2007-04-15 | Novo Nordisk As | Glp-1 derivate |
| HUP0301101A3 (en) | 1996-12-31 | 2009-03-30 | Reddy S Res Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| ES2158676T3 (es) | 1997-03-03 | 2001-09-01 | Aventis Cropscience Sa | Procedimiento para preparar compuestos intermedios de plaguicidas. |
| EP0986530A1 (en) | 1997-06-05 | 2000-03-22 | Venantius Limited | Indane compounds and their pharmaceutical use |
| KR20010021936A (ko) | 1997-07-16 | 2001-03-15 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 융합된 1,2,4-티아디아진 유도체, 그의 제조와 사용 |
| DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19844547C2 (de) * | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE19908539A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP1078632A1 (en) | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
-
2001
- 2001-08-31 DE DE10142665A patent/DE10142665B4/de not_active Expired - Fee Related
-
2002
- 2002-08-17 DE DE50214537T patent/DE50214537D1/de not_active Expired - Lifetime
- 2002-08-17 AT AT02772164T patent/ATE473962T1/de active
- 2002-08-17 CA CA2458524A patent/CA2458524C/en not_active Expired - Fee Related
- 2002-08-17 JP JP2003524968A patent/JP4250079B2/ja not_active Expired - Fee Related
- 2002-08-17 AU AU2002336983A patent/AU2002336983B2/en not_active Ceased
- 2002-08-17 IL IL16060402A patent/IL160604A0/xx unknown
- 2002-08-17 MX MXPA04001851A patent/MXPA04001851A/es active IP Right Grant
- 2002-08-17 EP EP02772164A patent/EP1423359B1/de not_active Expired - Lifetime
- 2002-08-17 WO PCT/EP2002/009204 patent/WO2003020697A1/de active Application Filing
- 2002-08-23 PE PE2002000809A patent/PE20030337A1/es not_active Application Discontinuation
- 2002-08-29 US US10/230,464 patent/US7081467B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1423359A1 (de) | 2004-06-02 |
| JP2005525298A (ja) | 2005-08-25 |
| AU2002336983B2 (en) | 2008-02-14 |
| ATE473962T1 (de) | 2010-07-15 |
| US20030153609A1 (en) | 2003-08-14 |
| CA2458524A1 (en) | 2003-03-13 |
| DE50214537D1 (de) | 2010-08-26 |
| WO2003020697A1 (de) | 2003-03-13 |
| IL160604A0 (en) | 2004-07-25 |
| US7081467B2 (en) | 2006-07-25 |
| DE10142665A1 (de) | 2003-03-27 |
| DE10142665B4 (de) | 2004-05-06 |
| JP4250079B2 (ja) | 2009-04-08 |
| EP1423359B1 (de) | 2010-07-14 |
| MXPA04001851A (es) | 2004-06-15 |
| CA2458524C (en) | 2010-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0408369A (pt) | derivados de indol úteis para o tratamento de doenças | |
| BRPI0416212A (pt) | derivado de piridazinona, composição farmacêutica, uso do derivado, método para o tratamento de um sujeito afligido com uma condição ou doença susceptìvel de melhora pela inibição de fosfodiesterase 4 e produto de combinação | |
| DE60206911D1 (de) | Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren | |
| NO20070224L (no) | 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav | |
| ATE381535T1 (de) | Phenethanolaminderivate | |
| ATE452129T1 (de) | N-phenyl-2-pyrimidine-amine derivatives | |
| NO20082496L (no) | Pyrazinderivater | |
| NO20033181L (no) | Substituerte alkylaminderivater og fremgangsmåter for anvendelse | |
| DE60224172D1 (de) | Formanilid-derivative als beta2-adrenorezeptor-agonisten | |
| CY1111693T1 (el) | Αντιιικοι παραγοντες | |
| EA200700099A1 (ru) | Производные пиридина | |
| MY139302A (en) | Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof | |
| ATE520668T1 (de) | Sigmarezeptor-inhibitoren | |
| NO20081844L (no) | Terapeutiske forbindelser | |
| NO20055649L (no) | Substituert dihydrokinazolin med antiviale egenskaper | |
| NO20076638L (no) | Nye 8-sulfonylamino-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptoren | |
| MXPA03008635A (es) | Compuestos de dihidropirimidina ciano sustituidos y su uso para tratar enfermedades. | |
| DK1448562T3 (da) | Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer | |
| YU75803A (sh) | Nova dihidropirimidinska jedinjenja koja su supstituisana na cijano grupi i njihova upotreba u lečenju oboljenja | |
| BRPI0407968A (pt) | derivados de oxamida úteis como inibidores de raf-quinase | |
| TW200728281A (en) | Novel N-sulfamoyl-piperidineamides for the prophylaxis or treatment of obesity and related conditions | |
| BRPI0508927A (pt) | compostos úteis para o tratamento de doenças | |
| IT1307786B1 (it) | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. | |
| PE20030337A1 (es) | Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos | |
| PE20030236A1 (es) | Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |