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PE20050159A1 - Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa - Google Patents

Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa

Info

Publication number
PE20050159A1
PE20050159A1 PE2004000535A PE2004000535A PE20050159A1 PE 20050159 A1 PE20050159 A1 PE 20050159A1 PE 2004000535 A PE2004000535 A PE 2004000535A PE 2004000535 A PE2004000535 A PE 2004000535A PE 20050159 A1 PE20050159 A1 PE 20050159A1
Authority
PE
Peru
Prior art keywords
oxo
pentanoico
pyridin
amino
alkyl
Prior art date
Application number
PE2004000535A
Other languages
English (en)
Inventor
Ronald Knegtel
Guy Brenchley
Jean-Damien Charrier
Michael Mortimore
John R Studley
Steven Durrant
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PE20050159A1 publication Critical patent/PE20050159A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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Abstract

SE REFIERE A UN COMPUESTO DERIVADOS DE ACIDO 3-[2-(3-AMINO-2-OXO-2H-PIRIDIN-1-IL)-ACETILAMINO]-4-OXO-PENTANOICO DE FORMULA I DONDE R1 ES R6C(O), R6SO2, R6OC(O)C(O), ENTRE OTROS; R2 ES H, CF3, HALO, OR7, NO2, ENTRE OTROS; R3 ES H, ALQUILO C1-C4; R4 ES COOH, COOR8; R5 ES CH2F, -CH2O-2,3,5,6-TETRAFLUOROFENILO; R6 ES ALQUILO C1-C12, CICLOALQUILO C3-C10, ARILO C6-C10, HETEROARILO C3-C10, ENTRE OTROS; R ES ALQUILO C1-C12, CICLOALQUILO C3-C10, ARILO C6-C10, HETEROCICLILO C3-C10, ENTRE OTROS; R ES HALOGENO, -OR7, -NOS, -CN, CF3, OXO, ENTRE OTROS DONDE R6 ESTA SUSTITUIDO CON R; R ES H, ALQUILO C1-C12, CICLOALQUILO C3-C10, ARILO C6-C10, HETEROARILO C5-C10, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS ACIDO (S,S)-3-[2-(3-ACETILAMINO-OXO-H-PIRIDIN-1-IL)-BUTIRILAMINO]-4-OXO-5-(2,3,5,6-TETRAFLUORO-FENOXI)-PENTANOICO, ACIDO (S,S)-3-{2-[3-(CICLOPROPANOCARBONIL-AMINO)-2-OXO-2H-PIRIDIN-1-IL]-BUTIRILAMINO}-4-OXO-5-(2,3,5,6-TETRAFLUORO-FENOXI)-PENTANOICO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE CASPASA QUE MEDIAN LA APOPTOSIS CELULAR Y LA INFLAMACION
PE2004000535A 2003-05-27 2004-05-26 Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa PE20050159A1 (es)

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