|
US3894037A
(en)
*
|
1971-05-24 |
1975-07-08 |
Ciba Geigy Corp |
Certain isothiocyanobenzimidazoles
|
|
IL54474A
(en)
*
|
1977-04-12 |
1982-04-30 |
Ciba Geigy Ag |
Benzimidazole derivatives,their preparation and anthelmintic compositions containing them
|
|
US4294926A
(en)
*
|
1979-06-15 |
1981-10-13 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
US4319039A
(en)
*
|
1979-06-15 |
1982-03-09 |
Merck & Co., Inc. |
Preparation of ammonium salt of hypocholesteremic fermentation product
|
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
US4444784A
(en)
*
|
1980-08-05 |
1984-04-24 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
|
DK149080C
(da)
*
|
1980-06-06 |
1986-07-28 |
Sankyo Co |
Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
|
|
JPS5889191A
(ja)
|
1981-11-20 |
1983-05-27 |
Sankyo Co Ltd |
３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
|
|
US4430502A
(en)
*
|
1982-08-13 |
1984-02-07 |
The Upjohn Company |
Pyridinyl substituted benzimidazoles and quinoxalines
|
|
US5354772A
(en)
*
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
|
AU570021B2
(en)
|
1982-11-22 |
1988-03-03 |
Novartis Ag |
Analogs of mevalolactone
|
|
US4911165A
(en)
*
|
1983-01-12 |
1990-03-27 |
Ethicon, Inc. |
Pliabilized polypropylene surgical filaments
|
|
GB8307865D0
(en)
*
|
1983-03-22 |
1983-04-27 |
Fujisawa Pharmaceutical Co |
Benzimidazole derivatives
|
|
US4681893A
(en)
*
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
|
US4782084A
(en)
*
|
1987-06-29 |
1988-11-01 |
Merck & Co., Inc. |
HMG-COA reductase inhibitors
|
|
US4885314A
(en)
|
1987-06-29 |
1989-12-05 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
|
US4820850A
(en)
*
|
1987-07-10 |
1989-04-11 |
Merck & Co., Inc. |
Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
|
|
US5180589A
(en)
*
|
1988-03-31 |
1993-01-19 |
E. R. Squibb & Sons, Inc. |
Pravastatin pharmaceuatical compositions having good stability
|
|
US5030447A
(en)
*
|
1988-03-31 |
1991-07-09 |
E. R. Squibb & Sons, Inc. |
Pharmaceutical compositions having good stability
|
|
US4916239A
(en)
*
|
1988-07-19 |
1990-04-10 |
Merck & Co., Inc. |
Process for the lactonization of mevinic acids and analogs thereof
|
|
US5118853A
(en)
*
|
1988-10-13 |
1992-06-02 |
Sandoz Ltd. |
Processes for the synthesis of 3-disubstituted aminoacroleins
|
|
US5290946A
(en)
*
|
1988-10-13 |
1994-03-01 |
Sandoz Ltd. |
Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
|
|
US4929437A
(en)
*
|
1989-02-02 |
1990-05-29 |
Merck & Co., Inc. |
Coenzyme Q10 with HMG-CoA reductase inhibitors
|
|
US5189164A
(en)
*
|
1989-05-22 |
1993-02-23 |
Sandoz Ltd. |
Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
|
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
JPH06759B2
(ja)
*
|
1989-09-22 |
1994-01-05 |
ファイザー製薬株式会社 |
新規なベンゾイミダゾール化合物
|
|
PH27357A
(en)
*
|
1989-09-22 |
1993-06-21 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives and pharmaceutical compositions comprising the same
|
|
US5420245A
(en)
*
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
|
US5041453A
(en)
*
|
1990-05-30 |
1991-08-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
|
|
FR2677020B1
(fr)
*
|
1991-05-31 |
1993-08-27 |
Cird Galderma |
Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
|
|
HU9203780D0
(en)
*
|
1991-12-12 |
1993-03-29 |
Sandoz Ag |
Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
|
|
US5612360A
(en)
|
1992-06-03 |
1997-03-18 |
Eli Lilly And Company |
Angiotensin II antagonists
|
|
US5604260A
(en)
*
|
1992-12-11 |
1997-02-18 |
Merck Frosst Canada Inc. |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
|
|
EP0604181A1
(en)
|
1992-12-21 |
1994-06-29 |
Eli Lilly And Company |
Antitumor compositions and method of treatment
|
|
CA2152792C
(en)
|
1993-01-15 |
2000-02-15 |
Stephen R. Bertenshaw |
Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
|
|
WO1994019357A1
(en)
|
1993-02-23 |
1994-09-01 |
Merrell Dow Pharmaceuticals Inc. |
Farnesyl:protein transferase inhibitors as anticancer agents
|
|
US5298627A
(en)
*
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
|
US5409944A
(en)
*
|
1993-03-12 |
1995-04-25 |
Merck Frosst Canada, Inc. |
Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
|
|
CA2118985A1
(en)
|
1993-04-02 |
1994-10-03 |
Dinesh V. Patel |
Heterocyclic inhibitors of farnesyl protein transferase
|
|
JPH09500615A
(ja)
*
|
1993-05-14 |
1997-01-21 |
ジェネンテク，インコーポレイテッド |
Ｒａｓ−ファルネシル転移酵素阻害剤
|
|
US5602098A
(en)
*
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
|
US5380738A
(en)
*
|
1993-05-21 |
1995-01-10 |
Monsanto Company |
2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
|
|
US5436265A
(en)
*
|
1993-11-12 |
1995-07-25 |
Merck Frosst Canada, Inc. |
1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
|
|
GB9602877D0
(en)
|
1996-02-13 |
1996-04-10 |
Merck Frosst Canada Inc |
3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
|
|
US5474995A
(en)
*
|
1993-06-24 |
1995-12-12 |
Merck Frosst Canada, Inc. |
Phenyl heterocycles as cox-2 inhibitors
|
|
US5852046A
(en)
|
1993-08-03 |
1998-12-22 |
Hoechst Aktiengesellschaft |
Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
|
|
EP0639573A1
(de)
|
1993-08-03 |
1995-02-22 |
Hoechst Aktiengesellschaft |
Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
|
|
US5728830A
(en)
|
1993-09-22 |
1998-03-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Farnesyltransferase inhibitor
|
|
US5661152A
(en)
*
|
1993-10-15 |
1997-08-26 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
US5719148A
(en)
|
1993-10-15 |
1998-02-17 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
IL111235A
(en)
|
1993-10-15 |
2001-03-19 |
Schering Plough Corp |
Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
|
|
JP2875393B2
(ja)
|
1993-10-15 |
1999-03-31 |
シェーリング コーポレイション |
Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物
|
|
US5721236A
(en)
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
AU698960B2
(en)
|
1993-10-15 |
1998-11-12 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
WO1995011917A1
(en)
|
1993-10-25 |
1995-05-04 |
Parke, Davis & Company |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
|
US5344991A
(en)
|
1993-10-29 |
1994-09-06 |
G.D. Searle & Co. |
1,2 diarylcyclopentenyl compounds for the treatment of inflammation
|
|
DK0677039T3
(da)
|
1993-11-04 |
1999-09-27 |
Abbott Lab |
Cyclobutanderivater som squalen-syntetase- og protein-farnesyltransferaseinhibitorer
|
|
US5783593A
(en)
|
1993-11-04 |
1998-07-21 |
Abbott Laboratories |
Inhibitors of squalene synthetase and protein farnesyltransferase
|
|
KR100362338B1
(ko)
|
1993-11-05 |
2003-04-08 |
워너-램버트 캄파니 |
단백질:파르네실트랜스퍼라아제의치환디-및트리펩티드억제제
|
|
US5466823A
(en)
*
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
|
US5393790A
(en)
*
|
1994-02-10 |
1995-02-28 |
G.D. Searle & Co. |
Substituted spiro compounds for the treatment of inflammation
|
|
AU2122795A
(en)
|
1994-03-15 |
1995-10-03 |
Eisai Co. Ltd. |
Isoprenyl transferase inhibitors
|
|
RU95104898A
(ru)
|
1994-03-31 |
1996-12-27 |
Бристоль-Мейерз Сквибб Компани (US) |
Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний
|
|
US5523430A
(en)
*
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
|
US5510510A
(en)
*
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US5563255A
(en)
|
1994-05-31 |
1996-10-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US6391636B1
(en)
*
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US6358932B1
(en)
*
|
1994-05-31 |
2002-03-19 |
Isis Pharmaceticals, Inc. |
Antisense oligonucleotide inhibition of raf gene expression
|
|
CN1150419A
(zh)
|
1994-06-10 |
1997-05-21 |
罗纳-布朗克罗莱尔股份有限公司 |
新的法呢基转移酶抑制剂、其制法及其药物组合物
|
|
US5571792A
(en)
*
|
1994-06-30 |
1996-11-05 |
Warner-Lambert Company |
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
|
|
WO1996005529A1
(en)
|
1994-08-09 |
1996-02-22 |
Micron Optics, Inc. |
Temperature compensated fiber fabry-perot filters
|
|
CA2155448A1
(en)
|
1994-08-11 |
1996-02-12 |
Katerina Leftheris |
Inhibitors of farnesyl protein transferase
|
|
DE69514367T2
(de)
|
1994-08-11 |
2000-07-27 |
Banyu Pharmaceutical Co., Ltd. |
Substituierte amidderivate
|
|
AU3192495A
(en)
|
1994-08-12 |
1996-03-07 |
Banyu Pharmaceutical Co., Ltd. |
N,n-disubstituted amic acid derivative
|
|
DE4429506B4
(de)
|
1994-08-19 |
2007-09-13 |
Degussa Gmbh |
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
|
|
DE4429653C2
(de)
|
1994-08-20 |
1997-04-03 |
Anton Dr More |
Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
|
|
EP0701907A1
(en)
|
1994-09-13 |
1996-03-20 |
Agfa-Gevaert N.V. |
A dye donor element for use in a thermal dye transfer process
|
|
US6037136A
(en)
*
|
1994-10-24 |
2000-03-14 |
Cold Spring Harbor Laboratory |
Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
|
|
KR100389754B1
(ko)
|
1994-11-22 |
2003-10-17 |
코닌클리즈케 필립스 일렉트로닉스 엔.브이. |
반도체장치
|
|
AU3971295A
(en)
|
1994-12-09 |
1996-06-26 |
Warner-Lambert Company |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
|
EA000164B1
(ru)
|
1995-01-09 |
1998-10-29 |
Магла Интернэшнл Лтд. |
Состав для печати изображения на поверхности изделия из каучукового латекса, способ печати изображения и изделия из каучукового латекса
|
|
WO1996021456A1
(en)
|
1995-01-12 |
1996-07-18 |
University Of Pittsburgh |
Inhibitors of prenyl transferases
|
|
US5741789A
(en)
*
|
1995-01-17 |
1998-04-21 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
FR2729390A1
(fr)
|
1995-01-18 |
1996-07-19 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730492B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730491B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5633272A
(en)
|
1995-02-13 |
1997-05-27 |
Talley; John J. |
Substituted isoxazoles for the treatment of inflammation
|
|
US5700806A
(en)
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
US5684013A
(en)
|
1995-03-24 |
1997-11-04 |
Schering Corporation |
Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
IL117580A0
(en)
|
1995-03-29 |
1996-07-23 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
|
|
US5712280A
(en)
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL117805A0
(en)
|
1995-04-07 |
1996-08-04 |
Schering Corp |
Carbonyl piperazinyl and piperidinyl compounds
|
|
US5891872A
(en)
|
1995-04-07 |
1999-04-06 |
Schering Corporation |
Tricyclic compounds
|
|
IL117798A
(en)
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
|
IL118101A0
(en)
|
1995-05-03 |
1996-09-12 |
Abbott Lab |
Inhibitors of farnesyltransferase
|
|
US5919780A
(en)
|
1995-06-16 |
1999-07-06 |
Warner Lambert Company |
Tricyclic inhibitors of protein farnesyltransferase
|
|
FR2736641B1
(fr)
|
1995-07-10 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
AT402617B
(de)
|
1995-07-11 |
1997-07-25 |
Datacon Schweitzer & Zeindl Gm |
Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
|
|
FR2736638B1
(fr)
|
1995-07-12 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9514265D0
(en)
|
1995-07-13 |
1995-09-13 |
Wellcome Found |
Hetrocyclic compounds
|
|
CH690163A5
(fr)
|
1995-07-28 |
2000-05-31 |
Symphar Sa |
Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
|
|
WO1997012613A1
(en)
|
1995-10-05 |
1997-04-10 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
US6001866A
(en)
|
1995-10-05 |
1999-12-14 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
US5717100A
(en)
*
|
1995-10-06 |
1998-02-10 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
|
US6020343A
(en)
*
|
1995-10-13 |
2000-02-01 |
Merck Frosst Canada, Inc. |
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
|
|
DE69627377T2
(de)
|
1995-11-06 |
2004-02-05 |
University Of Pittsburgh |
Inhibitoren der protein-isoprenyl-transferase
|
|
DE59609305D1
(de)
*
|
1995-11-17 |
2002-07-11 |
Biotechnolog Forschung Gmbh |
Epothilon-Derivate und deren Herstellung
|
|
JP2000500502A
(ja)
|
1995-11-22 |
2000-01-18 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル―タンパク質トランスフェラーゼ阻害剤
|
|
EP1162201B1
(en)
|
1995-12-08 |
2006-03-29 |
Janssen Pharmaceutica N.V. |
Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives
|
|
DE69635424T2
(de)
|
1995-12-22 |
2006-08-03 |
Schering Corp. |
Zur hemming der g-protein-funktion und zur behandlung proliferativer krankheiten geeignete tricyclische amide
|
|
BR9612434A
(pt)
*
|
1995-12-28 |
1999-12-28 |
Fujiwasa Pharmaceutical Co Ltd |
Derivados de benzimidazol
|
|
AU1529997A
(en)
|
1996-01-16 |
1997-08-11 |
Warner-Lambert Company |
Substituted histidine inhibitors of protein farnesyltransferase
|
|
GB9602029D0
(en)
*
|
1996-02-01 |
1996-04-03 |
Fujisawa Pharmaceutical Co |
New heterocyclic compounds
|
|
US6673927B2
(en)
|
1996-02-16 |
2004-01-06 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Farnesyl transferase inhibitors
|
|
CA2249601A1
(en)
|
1996-04-03 |
1997-10-23 |
Thorsten E. Fisher |
Inhibitors of farnesyl-protein transferase
|
|
PT1288206E
(pt)
*
|
1996-04-12 |
2008-11-14 |
Searle Llc |
Derivados de benzenossulfonamida substituídos como pró-fármacos de inibidores de cox-2
|
|
SK161098A3
(en)
|
1996-05-22 |
2000-06-12 |
Warner Lambert Co |
Inhibitors of protein farnesyl transferase
|
|
CA2256109A1
(en)
*
|
1996-05-23 |
1997-11-27 |
Applied Research Systems Ars Holding N.V. |
Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0918771A4
(en)
|
1996-07-15 |
2001-02-07 |
Bristol Myers Squibb Co |
THIADIOXOBENZODIAZEPINES FOR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS
|
|
US5861419A
(en)
*
|
1996-07-18 |
1999-01-19 |
Merck Frosst Canad, Inc. |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
|
|
FR2751649B1
(fr)
*
|
1996-07-26 |
1998-08-28 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
JP4579351B2
(ja)
*
|
1996-12-03 |
2010-11-10 |
スローン−ケッタリング インスティトュート フォア キャンサー リサーチ |
エポチロンの合成とその中間体及びその類似物並びにその使用
|
|
JP2001507699A
(ja)
|
1996-12-30 |
2001-06-12 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル蛋白トランスフェラーゼ阻害薬
|
|
EP1003374A4
(en)
|
1996-12-30 |
2000-05-31 |
Merck & Co Inc |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
|
|
US6127380A
(en)
*
|
1997-02-18 |
2000-10-03 |
American Home Products Corporation |
4-aminoalkoxy-1H-benzoimidazoles
|
|
US5932600A
(en)
*
|
1997-03-14 |
1999-08-03 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
WO1998040381A1
(en)
*
|
1997-03-14 |
1998-09-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
|
AR012634A1
(es)
*
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6187799B1
(en)
*
|
1997-05-23 |
2001-02-13 |
Onyx Pharmaceuticals |
Inhibition of raf kinase activity using aryl ureas
|
|
CA2294898A1
(en)
*
|
1997-07-03 |
1999-01-14 |
Neurogen Corporation |
Certain diarylimidazole derivatives; a new class of npy specific ligands
|
|
SI9700186B
(sl)
*
|
1997-07-14 |
2006-10-31 |
Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. |
Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
|
|
FR2766822B1
(fr)
*
|
1997-07-30 |
2001-02-23 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9716557D0
(en)
*
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
US6022884A
(en)
*
|
1997-11-07 |
2000-02-08 |
Amgen Inc. |
Substituted pyridine compounds and methods of use
|
|
US6204467B1
(en)
*
|
1998-03-24 |
2001-03-20 |
Ford Global Technologies, Inc. |
Method and apparatus for resistive welding
|
|
HUP0102058A3
(en)
*
|
1998-05-22 |
2002-05-28 |
Smithkline Beecham Corp |
Novel 2-alkyl substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and their use
|
|
US6420555B1
(en)
*
|
1998-06-16 |
2002-07-16 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Imidazolyl derivatives
|
|
FR2780973B1
(fr)
*
|
1998-07-09 |
2001-10-05 |
Hoechst Marion Roussel Inc |
Procede de preparation du 4-(3-pyridinyl)-1h-imidazole, et les intermediaires mis en oeuvre
|
|
DE19834751A1
(de)
*
|
1998-08-01 |
2000-02-03 |
Boehringer Ingelheim Pharma |
Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
SK286264B6
(sk)
|
1998-11-17 |
2008-06-06 |
Kumiai Chemical Industry Co., Ltd. |
Derivát pyrimidinylbenzimidazolu alebo triazinylbenzimidazolu, medziprodukty na jeho prípravu a poľnohospodársky/záhradnícky fungicíd s jeho obsahom
|
|
US6211177B1
(en)
*
|
1998-11-24 |
2001-04-03 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
|
|
US6339083B1
(en)
|
1998-12-14 |
2002-01-15 |
Bayer Aktiengesellschaft |
Multiheterocyclic pharmAceuticals
|
|
US7351834B1
(en)
*
|
1999-01-13 |
2008-04-01 |
Bayer Pharmaceuticals Corporation |
ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Ｋｄｒに特異的な抗体およびその使用
|
|
GB9904387D0
(en)
|
1999-02-25 |
1999-04-21 |
Pharmacia & Upjohn Spa |
Antitumour synergistic composition
|
|
EP1187633A4
(en)
|
1999-04-08 |
2005-05-11 |
Arch Dev Corp |
USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY
|
|
WO2000061580A1
(en)
|
1999-04-12 |
2000-10-19 |
Aventis Pharma Limited |
Substituted bicyclic heteroaryl compounds as integrin antagonists
|
|
CA2373883A1
(en)
|
1999-07-02 |
2001-01-11 |
Stuart A. Lipton |
Method of reducing neuronal injury or apoptosis
|
|
US6545004B1
(en)
|
1999-10-27 |
2003-04-08 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
|
HUP0203430A3
(en)
|
1999-10-27 |
2003-07-28 |
Cytokinetics Inc South San Fra |
Quinazolinones and their use
|
|
JP2003525936A
(ja)
|
2000-03-06 |
2003-09-02 |
スミスクライン ビーチャム パブリック リミテッド カンパニー |
Ｒａｆキナーゼ阻害物質としてのイミダゾール誘導体
|
|
EP1268432A1
(en)
|
2000-03-24 |
2003-01-02 |
Millenium Pharmaceuticals, Inc. |
ISOQUINOLONE INHIBITORS OF FACTOR Xa
|
|
EP1272483A2
(en)
|
2000-03-24 |
2003-01-08 |
Millenium Pharmaceuticals, Inc. |
OXINDOLE INHIBITORS OF FACTOR Xa
|
|
JP2001322903A
(ja)
|
2000-05-15 |
2001-11-20 |
Kumiai Chem Ind Co Ltd |
農園芸用殺菌剤組成物
|
|
ATE357257T1
(de)
*
|
2000-07-27 |
2007-04-15 |
Pharmacia Corp |
Kombinationstherapie mit epoxy-steroidalen aldosteronantagonisten und kalziumkanalblocker zur behandlung von kongestivem herzversagen
|
|
AU2001285349A1
(en)
*
|
2000-08-30 |
2002-03-13 |
The Board Of Trustees Of The University Of Arkansas |
Induction of ldl receptor expression by extracellular-signal regulated kinase, erk-1/2
|
|
JP4734705B2
(ja)
|
2000-10-31 |
2011-07-27 |
三菱化学株式会社 |
リチウム二次電池用正極材料、リチウム二次電池用正極及びリチウム二次電池
|
|
DE10060292A1
(de)
*
|
2000-12-05 |
2002-06-20 |
Aventis Pharma Gmbh |
Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament
|
|
EP1557410B1
(en)
*
|
2000-12-15 |
2009-09-16 |
Vertex Pharmaceuticals Incorporated |
Bacterial gyrase inhibitors and uses thereof
|
|
TW593278B
(en)
*
|
2001-01-23 |
2004-06-21 |
Wyeth Corp |
1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
|
|
EP1358175A2
(en)
*
|
2001-02-08 |
2003-11-05 |
Karo Bio Ab |
Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands
|
|
US20050038022A1
(en)
*
|
2001-03-26 |
2005-02-17 |
Unisearch Limited |
Method for treatment of cancer and compositions for use therein
|
|
AU2002307163B2
(en)
|
2001-04-10 |
2006-06-29 |
Merck & Co., Inc. |
A method of treating cancer
|
|
EP1379251B1
(en)
|
2001-04-10 |
2008-07-09 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
US6958334B2
(en)
|
2001-04-10 |
2005-10-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
CA2444596A1
(en)
|
2001-04-16 |
2002-10-24 |
Tanabe Seiyaku Co., Ltd. |
Large conductance calcium-activated k channel opener
|
|
US6855714B2
(en)
*
|
2001-07-06 |
2005-02-15 |
Schering Aktiengesellschaft |
1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
|
|
WO2003013526A1
(en)
|
2001-08-08 |
2003-02-20 |
Merck & Co. Inc. |
Anticoagulant compounds
|
|
WO2003024899A2
(en)
|
2001-09-17 |
2003-03-27 |
Bristol-Myers Squibb Company |
CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE)
|
|
JP4445262B2
(ja)
*
|
2001-10-09 |
2010-04-07 |
アムジェン インコーポレイテッド |
抗炎症剤としてのイミダゾール誘導体
|
|
US7039413B2
(en)
*
|
2001-10-24 |
2006-05-02 |
Ntt Docomo, Inc. |
Mobile station transfer control system, cell transfer control method, mobile station, cell transfer control method at mobile station, cell transfer control program, control apparatus, and allocating method of communication resources
|
|
EP1444209A4
(en)
|
2001-11-07 |
2005-02-16 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESIN
|
|
TW200300140A
(en)
|
2001-11-14 |
2003-05-16 |
Novartis Ag |
Organic compounds
|
|
TW200303742A
(en)
|
2001-11-21 |
2003-09-16 |
Novartis Ag |
Organic compounds
|
|
UA83620C2
(ru)
*
|
2001-12-05 |
2008-08-11 |
Уайт |
Замещенные бензоксазолы и их аналоги как эстрогенные агенты
|
|
DE60231439D1
(de)
|
2001-12-06 |
2009-04-16 |
Merck & Co Inc |
Mitotische kinesinhemmer
|
|
WO2003049527A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
AU2002351183B2
(en)
|
2001-12-06 |
2008-05-08 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
|
WO2003050122A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
ATE372341T1
(de)
|
2001-12-06 |
2007-09-15 |
Merck & Co Inc |
Inhibitoren von mitotischem kinesin
|
|
JP4136395B2
(ja)
|
2002-02-22 |
2008-08-20 |
クミアイ化学工業株式会社 |
農園芸用殺菌剤組成物
|
|
CA2478068C
(en)
|
2002-03-08 |
2011-02-08 |
Merck & Co., Inc. |
Dihydropyrazole compounds useful for treating or preventing cancer
|
|
US8299108B2
(en)
|
2002-03-29 |
2012-10-30 |
Novartis Ag |
Substituted benzazoles and methods of their use as inhibitors of raf kinase
|
|
ES2336094T3
(es)
|
2002-03-29 |
2010-04-08 |
Novartis Vaccines And Diagnostics, Inc. |
Benzazoles sustituidos y uso de los mismos como inhibidores de quinasa raf.
|
|
AU2003231359B2
(en)
|
2002-04-16 |
2009-04-30 |
Teijin Limited |
Piperidine derivatives having CCR3 antagonism
|
|
KR20040104596A
(ko)
|
2002-04-25 |
2004-12-10 |
데이진 가부시키가이샤 |
Ｃｃｒ３ 길항 작용을 갖는 ４,４-２치환 피페리딘 유도체
|
|
US20050234080A1
(en)
|
2002-05-23 |
2005-10-20 |
Coleman Paul J |
Mitotic kinesin inhibitors
|
|
JP2006506401A
(ja)
|
2002-05-23 |
2006-02-23 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害薬
|
|
EP1515724B1
(en)
|
2002-06-14 |
2009-10-21 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
JP4463679B2
(ja)
|
2002-06-14 |
2010-05-19 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害剤
|
|
TW200400816A
(en)
*
|
2002-06-26 |
2004-01-16 |
Lilly Co Eli |
Tricyclic steroid hormone nuclear receptor modulators
|
|
CN101723941A
(zh)
|
2002-08-09 |
2010-06-09 |
阿斯利康(瑞典)有限公司 |
作为代谢型谷氨酸受体-5调节剂的“1,2,4”二唑
|
|
CA2498047C
(en)
*
|
2002-09-18 |
2009-05-19 |
Pfizer Products Inc. |
Novel imidazole compounds as transforming growth factor (tgf) inhibitors
|
|
AU2003271548A1
(en)
|
2002-10-13 |
2004-05-04 |
Neurosearch A/S |
Use of skca channel blocking drugs for combating parkinson's disease
|
|
EP1556140A4
(en)
|
2002-10-15 |
2006-04-19 |
Synta Pharmaceuticals Corp |
NEW COMPOUNDS
|
|
US20050054705A1
(en)
*
|
2003-02-04 |
2005-03-10 |
Aventis Pharma Deutschland Gmbh |
N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
|
|
US7531553B2
(en)
*
|
2003-03-21 |
2009-05-12 |
Amgen Inc. |
Heterocyclic compounds and methods of use
|
|
ES2423800T3
(es)
*
|
2003-03-28 |
2013-09-24 |
Novartis Vaccines And Diagnostics, Inc. |
Uso de compuestos orgánicos para la inmunopotenciación
|
|
KR100849747B1
(ko)
|
2003-05-20 |
2008-07-31 |
노파르티스 아게 |
과산화소체 증식체-활성화 수용체의 리간드로서의 ｎ-아실질소 헤테로환
|
|
JP2007500241A
(ja)
|
2003-05-29 |
2007-01-11 |
シンタ ファーマシューティカルズ コーポレーション |
過度の骨量減少に関連する疾患の予防及び治療用の複素環化合物
|
|
WO2005005421A1
(en)
|
2003-07-08 |
2005-01-20 |
Novartis Ag |
Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds
|
|
JP2007502298A
(ja)
|
2003-08-14 |
2007-02-08 |
スミスクライン ビーチャム コーポレーション |
化合物
|
|
EP2213661B1
(en)
|
2003-09-26 |
2011-07-20 |
Exelixis Inc. |
c-Met Modulators and Methods of Use
|
|
ES2327418T3
(es)
|
2003-10-16 |
2009-10-29 |
Novartis Vaccines And Diagnostics, Inc. |
Benzazoles sustituidos y uso de los mismos como inhibidores de la quinasa raf.
|
|
US7470712B2
(en)
|
2004-01-21 |
2008-12-30 |
Bristol-Myers Squibb Company |
Amino-benzazoles as P2Y1 receptor inhibitors
|
|
CA2553433A1
(en)
|
2004-01-23 |
2005-08-11 |
Amgen Inc. |
Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer
|
|
TWI387592B
(zh)
*
|
2005-08-30 |
2013-03-01 |
Novartis Ag |
經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
|
|
CN101516335B
(zh)
*
|
2006-07-21 |
2014-01-08 |
诺瓦提斯公司 |
苯并咪唑基吡啶基醚的制剂
|