PL377314A1 - Modulatory astmy i zapaleń na tle alergicznym - Google Patents
Modulatory astmy i zapaleń na tle alergicznymInfo
- Publication number
- PL377314A1 PL377314A1 PL377314A PL37731403A PL377314A1 PL 377314 A1 PL377314 A1 PL 377314A1 PL 377314 A PL377314 A PL 377314A PL 37731403 A PL37731403 A PL 37731403A PL 377314 A1 PL377314 A1 PL 377314A1
- Authority
- PL
- Poland
- Prior art keywords
- asthma
- allergic inflammation
- inflammation modulators
- modulators
- allergic
- Prior art date
Links
- 230000009285 allergic inflammation Effects 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
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- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
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Families Citing this family (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2784937A1 (en) | 2002-05-24 | 2003-12-04 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
| US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
| CN101077867B (zh) | 2002-11-18 | 2012-10-10 | 坎莫森特里克斯公司 | 芳基磺酰胺 |
| US7321001B2 (en) | 2002-12-20 | 2008-01-22 | Amgen Inc. | Asthma and allergic inflammation modulators |
| CN1511828A (zh) * | 2002-12-31 | 2004-07-14 | �й������ž�����ҽѧ��ѧԺ����ҽ | 磺酰苯胺类衍生物及其医药用途 |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| US20080254053A1 (en) * | 2003-04-09 | 2008-10-16 | Mullally John P | Protocol for treatment of diabetes |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| DE602004011985T2 (de) * | 2003-11-25 | 2009-03-05 | Eli Lilly And Co., Indianapolis | Modulatoren des peroxisomproliferatoraktivierten rezeptors |
| PT1701940E (pt) * | 2003-12-23 | 2008-07-30 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-benzil-amina como ssri |
| PT1718649E (pt) | 2004-01-31 | 2009-08-06 | Actimis Pharmaceuticals Inc | Derivados de ácido imidazo[1,2-c]pirimidinilacético |
| PL1725553T3 (pl) | 2004-03-11 | 2008-10-31 | Idorsia Pharmaceuticals Ltd | Pochodne tetrahydropirydoindolu |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| AR051966A1 (es) | 2004-11-23 | 2007-02-21 | Astrazeneca Ab | Derivados de acido fenoxiacetico utiles para el tratamiento de enfermedades respiratorias |
| CA2588953A1 (en) | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Ppar active compounds |
| US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| MX2007012794A (es) | 2005-04-13 | 2008-02-22 | Astion Pharma As | Composiciones para el tratamiento de trastornos del tejido conectivo de la piel. |
| PT1871374E (pt) * | 2005-04-21 | 2011-09-30 | Merck Serono Sa | Pirazinossulfonamidas substituídas |
| GB0510584D0 (en) * | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| WO2007014008A2 (en) * | 2005-07-22 | 2007-02-01 | Glaxo Group Limted | Benzenesulfonamide inhibitor of ccr2 chemokine receptor |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007039736A1 (en) * | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
| WO2007052023A2 (en) * | 2005-11-05 | 2007-05-10 | Astrazeneca Ab | Novel compounds |
| GB0525141D0 (en) * | 2005-12-09 | 2006-01-18 | Novartis Ag | Organic compounds |
| EP1963259B1 (en) * | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| US20100137163A1 (en) | 2006-01-11 | 2010-06-03 | Link Darren R | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors |
| WO2007110876A2 (en) * | 2006-03-24 | 2007-10-04 | Panacea Biotec Ltd. | Novel sulfonanilide derivatives, pharmaceutical compositions comprising the same and process thereof |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2021113A2 (en) | 2006-05-11 | 2009-02-11 | Raindance Technologies, Inc. | Microfluidic devices |
| EA200802415A1 (ru) * | 2006-06-09 | 2009-06-30 | Икос Корпорейшн | Замещенные фенилуксусные кислоты в качестве dp-2-антагонистов |
| MX2008015638A (es) * | 2006-06-09 | 2009-01-09 | Icos Corp | Acidos fenil aceticos sustituidos como antagonistas de dp-2. |
| US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
| WO2008008374A2 (en) * | 2006-07-14 | 2008-01-17 | Chemocentryx, Inc. | Ccr2 inhibitors and methods of use thereof |
| KR20090042808A (ko) | 2006-07-22 | 2009-04-30 | 옥사겐 리미티드 | 씨알티에이치2 길항제 활성을 갖는 화합물 |
| WO2008021123A1 (en) | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| PT2057115E (pt) * | 2006-08-21 | 2012-12-26 | Array Biopharma Inc | Derivados de ácido fenoxifenilacético substituídos na posição |
| CA2669915C (en) | 2006-11-17 | 2012-02-07 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| WO2008127893A1 (en) * | 2007-04-04 | 2008-10-23 | Hight H Thomas | Niacin-based pharmaceutical compositions |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| KR101849560B1 (ko) | 2007-07-12 | 2018-04-17 | 케모센트릭스, 인크. | 염증의 치료를 위한 ccr2 조절물질로서 융합된 헤테로아릴 피리딜과 페닐 벤젠술폰아마이드 |
| WO2009042138A1 (en) | 2007-09-25 | 2009-04-02 | Actimis Pharmaceuticals, Inc. | Alkylthio pyrimidines as crth2 antagonists |
| KR20100061746A (ko) | 2007-09-25 | 2010-06-08 | 액티미스 파마수티컬스 인코포레이티드 | Crth2 길항제로서의 2-s-벤질 치환된 피리미딘 |
| WO2009061681A2 (en) * | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc | Antagonists of pgd2 receptors |
| WO2009061676A2 (en) * | 2007-11-06 | 2009-05-14 | Amira Pharmaceuticals, Inc. | Antagonists of pgd2 receptors |
| US8394836B2 (en) | 2007-12-14 | 2013-03-12 | Pulmagen Therapeutics (Asthma) Limited | Indoles and their therapeutic use |
| KR20100102668A (ko) * | 2007-12-19 | 2010-09-24 | 암젠 인크 | 염증 조절제로서의 페닐 아세트산 유도체 |
| US20110060026A1 (en) * | 2008-01-18 | 2011-03-10 | George Hynd | Indoles Active on CRTH2 Receptor |
| EP2250161B1 (en) | 2008-01-18 | 2013-10-16 | Atopix Therapeutics Limited | Compounds having crth2 antagonist activity |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| WO2009093026A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| US8168673B2 (en) | 2008-01-22 | 2012-05-01 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| EP2257524B1 (en) * | 2008-02-01 | 2016-01-06 | Brickell Biotech, Inc. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
| US20110098352A1 (en) * | 2008-02-01 | 2011-04-28 | Amira Pharmaceuticals, Inc. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
| JP2011512359A (ja) | 2008-02-14 | 2011-04-21 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアンタゴニストとしての環式ジアリールエーテル化合物 |
| RU2496775C2 (ru) | 2008-02-22 | 2013-10-27 | Оцука Фармасьютикал Ко., Лтд | Соединение бензодиазепина и фармацевтическая композиция |
| JP2011513242A (ja) | 2008-02-25 | 2011-04-28 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体アンタゴニスト |
| US8426449B2 (en) | 2008-04-02 | 2013-04-23 | Panmira Pharmaceuticals, Llc | Aminoalkylphenyl antagonists of prostaglandin D2 receptors |
| US8501959B2 (en) | 2008-06-24 | 2013-08-06 | Panmira Pharmaceuticals, Llc | Cycloalkane[B]indole antagonists of prostaglandin D2 receptors |
| SG2014013528A (en) * | 2008-06-25 | 2014-07-30 | Array Biopharma Inc | 6-substituted phenoxychroman carboxylic acid derivatives |
| US20110190227A1 (en) * | 2008-07-03 | 2011-08-04 | Amira Pharmaceuticals, Inc. | Antagonists of Prostaglandin D2 Receptors |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010039977A2 (en) | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
| GB2465062B (en) | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
| NZ591914A (en) | 2008-11-17 | 2013-04-26 | Hoffmann La Roche | Naphthylacetic acids |
| WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
| WO2010075200A1 (en) | 2008-12-22 | 2010-07-01 | Array Biopharma Inc. | 7-phenoxychroman carboxylic acid derivatives |
| EP2411148B1 (en) | 2009-03-23 | 2018-02-21 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| WO2011002814A2 (en) * | 2009-06-30 | 2011-01-06 | Ligand Pharmaceuticals Inc. | Biaryl oxyacetic acid compounds |
| US20120184493A1 (en) * | 2009-07-31 | 2012-07-19 | Panmira Pharmaceeuticals, Llc | Dermal formulations of dp2 receptor antagonists |
| US8785393B2 (en) | 2009-07-31 | 2014-07-22 | Panmira Pharmaceuticals, Llc | Ophthalmic pharmaceutical compositions of DP2 receptor antagonists |
| MX2012001542A (es) * | 2009-08-05 | 2012-06-19 | Panmira Pharmaceuticals Llc | Antagonista dp2 y usos del mismo. |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| BR112012003871A2 (pt) | 2009-08-21 | 2015-09-08 | Otsuka Pharma Co Ltd | processo para a produção de composto de benzo[b][1,4]diazepina-2,4-diona |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| WO2011079176A2 (en) | 2009-12-23 | 2011-06-30 | Raindance Technologies, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| PH12012501280A1 (en) | 2009-12-23 | 2013-02-04 | Ironwood Pharmaceuticals Inc | Crth2 modulators |
| PH12012501349A1 (en) | 2010-01-06 | 2013-01-14 | Panmira Pharmaceuticals Llc | Dp2 antagonist and uses thereof |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| JP5934657B2 (ja) | 2010-02-12 | 2016-06-15 | レインダンス テクノロジーズ, インコーポレイテッド | デジタル検体分析 |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US20130178475A1 (en) | 2010-03-17 | 2013-07-11 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| US8748442B2 (en) | 2010-06-30 | 2014-06-10 | Ironwood Pharmaceuticals, Inc. | sGC stimulators |
| BR112013000254A2 (pt) | 2010-07-05 | 2016-05-24 | Actelion Pharmaceuticals Ltd | derivados heterocíclicos 1-fenil-substituídos e seu uso como moduladores do receptor de prostaglandina d2 |
| US20130259830A1 (en) | 2010-07-12 | 2013-10-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| WO2012009137A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| US20140113898A1 (en) * | 2010-11-08 | 2014-04-24 | Zalicus Pharmaceuticals Ltd. | Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers |
| WO2012064559A1 (en) | 2010-11-09 | 2012-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| WO2012109600A2 (en) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US9556470B2 (en) | 2011-06-02 | 2017-01-31 | Raindance Technologies, Inc. | Enzyme quantification |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| SG11201402796SA (en) | 2011-12-16 | 2014-06-27 | Atopix Therapeutics Ltd | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| BR112014015081A2 (pt) | 2011-12-21 | 2017-06-13 | Actelion Pharmaceuticals Ltd | derivados heterocíclicos e seu uso como moduladores do receptor d2 de prostaglandina |
| EP3112363A1 (en) | 2011-12-27 | 2017-01-04 | Ironwood Pharmaceuticals, Inc. | 2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-pyrimidine derivatives and related compounds as soluble guanylate cyclase (sgc) stimulators for the treatment of pulmonary hypertension |
| KR20150027827A (ko) | 2012-07-05 | 2015-03-12 | 액테리온 파마슈티칼 리미티드 | 1-페닐-치환된 헤테로시클릴 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 그의 용도 |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| US9487508B2 (en) | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| JP2016517432A (ja) | 2013-03-15 | 2016-06-16 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激薬 |
| CN104341307B (zh) * | 2013-08-05 | 2016-12-28 | 北京京朋汇药业研究发展有限公司 | 苯乙酸衍生物及其抗肿瘤用途 |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| CN106304835A (zh) | 2013-12-11 | 2017-01-04 | 铁木医药有限公司 | sGC刺激剂 |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| US20160324856A1 (en) | 2014-01-13 | 2016-11-10 | Ironwood Pharmaceuticals, Inc. | Use of sgc stimulators for the treatment of neuromuscular disorders |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| US20170298055A1 (en) | 2014-09-17 | 2017-10-19 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| AU2015317823A1 (en) | 2014-09-17 | 2017-03-23 | Ironwood Pharmaceuticals, Inc. | sGC stimulators |
| JP6624616B2 (ja) | 2014-09-17 | 2019-12-25 | サイクレリオン・セラピューティクス,インコーポレーテッド | sGC刺激剤 |
| WO2016128565A1 (en) | 2015-02-13 | 2016-08-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| JP2019524710A (ja) | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Sgc刺激剤の固体形態 |
| EP3481837B1 (en) | 2016-07-07 | 2023-12-06 | Cyclerion Therapeutics, Inc. | Phosphorus prodrugs of sgc stimulators |
| IL294410B2 (en) | 2016-11-23 | 2024-02-01 | Chemocentryx Inc | Method of treating focal segmental glomerulosclerosis |
| JP2020536919A (ja) | 2017-10-11 | 2020-12-17 | ケモセントリックス, インコーポレイテッド | Ccr2アンタゴニストによる巣状分節性糸球体硬化症の治療 |
| PE20220252A1 (es) | 2019-04-03 | 2022-02-16 | Aligos Therapeutics Inc | Compuestos de pirrol |
| CN112500281A (zh) * | 2020-12-07 | 2021-03-16 | 唐山师范学院 | 丁香酸的制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8704158D0 (en) | 1987-02-23 | 1987-04-01 | Wellcome Found | Substituted hydantoin compounds |
| DE4041780A1 (de) * | 1990-12-24 | 1992-06-25 | Boehringer Mannheim Gmbh | Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel |
| EP0706508A1 (en) | 1993-06-30 | 1996-04-17 | The Wellcome Foundation Limited | Anti-atherosclerotic diaryl compounds |
| US5545669A (en) * | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
| GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
| PT799206E (pt) | 1994-12-20 | 2003-01-31 | Hoffmann La Roche | Derivados de aril- e heteroaril-sulfonamida processo para a sua preparacao e sua utilizacao como antagonistas da endotelina |
| US6008234A (en) | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| DE69717474T2 (de) | 1996-09-12 | 2003-06-26 | Schering Ag | Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien |
| TW523506B (en) * | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| JPH11202458A (ja) | 1998-01-16 | 1999-07-30 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| AU3665199A (en) | 1998-04-29 | 1999-11-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
| JP2000007646A (ja) * | 1998-06-16 | 2000-01-11 | Ono Pharmaceut Co Ltd | スルフォンアミド誘導体およびそれらを有効成分と して含有する薬剤 |
| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| AU2825000A (en) | 1999-03-10 | 2000-09-28 | Shionogi & Co., Ltd. | Medicinal compositions with (2.2.1) and (3.1.1) bicycloskeleton antagonistic to both of pgd2/txa2 receptors |
| ATE315230T1 (de) | 1999-08-23 | 2006-02-15 | Bml Inc | Verfahren zum identifizieren von prostaglandin d2 rezeptor modulatoren |
| US6531291B1 (en) * | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
| US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
| WO2001094309A1 (fr) | 2000-06-02 | 2001-12-13 | Shionogi & Co., Ltd. | Composition medicamenteuse antagoniste pour les recepteurs de pgd2/txa2 |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| AU2002229611A1 (en) | 2000-12-08 | 2002-06-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of active compounds capable of modulating the intracellular pathway triggered by the dp receptor in langerhans cells |
| EP1395590B1 (en) | 2001-05-23 | 2006-09-27 | Merck Frosst Canada & Co. | Dihydropyrrolo¬1,2-a|indole and tetrahydropyrido¬1,2-a|indole derivatives as prostaglandin d2 receptor antagonists |
| US7491748B2 (en) * | 2001-08-09 | 2009-02-17 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| NZ535309A (en) | 2002-03-19 | 2006-05-26 | Ono Pharmaceutical Co | Carboxylic acid compounds and drugs containing the compounds as the active ingredient |
| WO2003097042A1 (fr) | 2002-05-16 | 2003-11-27 | Shionogi & Co., Ltd. | Antagoniste de recepteur de pdg2 |
| US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
| GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| US7321001B2 (en) | 2002-12-20 | 2008-01-22 | Amgen Inc. | Asthma and allergic inflammation modulators |
-
2003
- 2003-12-19 US US10/742,281 patent/US7321001B2/en active Active
- 2003-12-19 ES ES03814219T patent/ES2401079T3/es not_active Expired - Lifetime
- 2003-12-19 KR KR1020057011677A patent/KR20050111314A/ko not_active Abandoned
- 2003-12-19 WO PCT/US2003/040617 patent/WO2004058164A2/en active Application Filing
- 2003-12-19 NZ NZ541234A patent/NZ541234A/en not_active IP Right Cessation
- 2003-12-19 ZA ZA200505523A patent/ZA200505523B/en unknown
- 2003-12-19 MX MXPA05006701A patent/MXPA05006701A/es active IP Right Grant
- 2003-12-19 CA CA2511214A patent/CA2511214C/en not_active Expired - Fee Related
- 2003-12-19 AU AU2003297398A patent/AU2003297398B2/en not_active Ceased
- 2003-12-19 EA EA200501017A patent/EA011087B1/ru not_active IP Right Cessation
- 2003-12-19 PL PL377314A patent/PL377314A1/pl not_active Application Discontinuation
- 2003-12-19 JP JP2004563827A patent/JP4457017B2/ja not_active Expired - Fee Related
- 2003-12-19 CN CNB2003801097235A patent/CN100406007C/zh not_active Expired - Fee Related
- 2003-12-19 BR BR0317591-0A patent/BR0317591A/pt not_active IP Right Cessation
- 2003-12-19 EP EP03814219A patent/EP1585511B1/en not_active Expired - Lifetime
-
2005
- 2005-06-22 IS IS7907A patent/IS7907A/is unknown
- 2005-06-24 NO NO20053114A patent/NO20053114L/no not_active Application Discontinuation
-
2007
- 2007-11-26 US US11/986,863 patent/US7541383B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20040220237A1 (en) | 2004-11-04 |
| CA2511214C (en) | 2012-12-18 |
| ZA200505523B (en) | 2006-09-27 |
| IS7907A (is) | 2005-06-22 |
| EP1585511A2 (en) | 2005-10-19 |
| MXPA05006701A (es) | 2006-03-30 |
| EP1585511A4 (en) | 2007-08-29 |
| KR20050111314A (ko) | 2005-11-24 |
| EP1585511B1 (en) | 2013-01-23 |
| ES2401079T3 (es) | 2013-04-16 |
| EA200501017A1 (ru) | 2006-02-24 |
| US7541383B2 (en) | 2009-06-02 |
| AU2003297398A1 (en) | 2004-07-22 |
| AU2003297398B2 (en) | 2009-09-24 |
| NO20053114L (no) | 2005-09-19 |
| CN100406007C (zh) | 2008-07-30 |
| WO2004058164A3 (en) | 2004-08-26 |
| NO20053114D0 (no) | 2005-06-24 |
| NZ541234A (en) | 2008-06-30 |
| US20080085891A1 (en) | 2008-04-10 |
| WO2004058164A2 (en) | 2004-07-15 |
| CA2511214A1 (en) | 2004-07-15 |
| BR0317591A (pt) | 2005-11-22 |
| US7321001B2 (en) | 2008-01-22 |
| EA011087B1 (ru) | 2008-12-30 |
| JP4457017B2 (ja) | 2010-04-28 |
| CN1767823A (zh) | 2006-05-03 |
| JP2006516143A (ja) | 2006-06-22 |
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