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PT2450446E - Aumento dos níveis de alcalóides nicotínicos - Google Patents

Aumento dos níveis de alcalóides nicotínicos Download PDF

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Publication number
PT2450446E
PT2450446E PT111872016T PT11187201T PT2450446E PT 2450446 E PT2450446 E PT 2450446E PT 111872016 T PT111872016 T PT 111872016T PT 11187201 T PT11187201 T PT 11187201T PT 2450446 E PT2450446 E PT 2450446E
Authority
PT
Portugal
Prior art keywords
increasing levels
nicotinic alkaloids
alkaloids
nicotinic
levels
Prior art date
Application number
PT111872016T
Other languages
English (en)
Inventor
Takashi Hashimoto
M Kajikawa
Original Assignee
22Nd Century Ltd Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 22Nd Century Ltd Llc filed Critical 22Nd Century Ltd Llc
Publication of PT2450446E publication Critical patent/PT2450446E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
PT111872016T 2006-09-13 2006-09-13 Aumento dos níveis de alcalóides nicotínicos PT2450446E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/004043 WO2007072224A2 (en) 2006-09-13 2006-09-13 Increasing levels of nicotinic alkaloids

Publications (1)

Publication Number Publication Date
PT2450446E true PT2450446E (pt) 2015-09-15

Family

ID=38189038

Family Applications (1)

Application Number Title Priority Date Filing Date
PT111872016T PT2450446E (pt) 2006-09-13 2006-09-13 Aumento dos níveis de alcalóides nicotínicos

Country Status (9)

Country Link
EP (4) EP2061889B1 (pt)
JP (1) JP5087777B2 (pt)
ES (3) ES2478633T3 (pt)
HK (1) HK1203545A1 (pt)
HU (1) HUE026819T2 (pt)
PL (3) PL2061889T3 (pt)
PT (1) PT2450446E (pt)
TW (4) TWI659102B (pt)
WO (1) WO2007072224A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
JP5540068B2 (ja) * 2010-02-17 2014-07-02 日本たばこ産業株式会社 植物内容成分の調節因子、およびその利用
CN102258213B (zh) * 2011-02-25 2013-07-17 福州农博士生物技术有限公司 烟丝生产用复合酶菌制剂及其制备方法
WO2013107527A1 (en) * 2012-01-21 2013-07-25 Vib Vzw Novel genes and uses thereof for secondary metabolite production in plants
US9580722B2 (en) 2013-03-01 2017-02-28 North Carolina State University Transcription factors that regulate nicotine biosynthesis in tobacco
KR102851176B1 (ko) * 2018-07-26 2025-08-28 알트리아 클라이언트 서비시즈 엘엘씨 알칼로이드 수준이 변경된 담배 식물 및 제품을 생산하기 위한 pmt 공학에 기초한 조성물 및 방법
CN110452916B (zh) * 2019-09-03 2020-11-10 西南大学 莨菪醛还原酶及其应用
WO2021072288A1 (en) * 2019-10-10 2021-04-15 Altria Client Services Llc Compositions and methods based on qpt engineering for producing tobacco plants and products having altered alkaloid levels
CN113073062B (zh) * 2021-04-07 2023-03-31 广西中烟工业有限责任公司 一种复合微生物制剂及其制备方法和应用
CN115708415A (zh) * 2021-06-21 2023-02-21 韩国烟草人参公社 Qpt基因工程改造的植物细胞及其利用方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407956A (en) 1981-03-13 1983-10-04 The Regents Of The University Of California Cloned cauliflower mosaic virus DNA as a plant vehicle
US5837848A (en) 1990-03-16 1998-11-17 Zeneca Limited Root-specific promoter
DE69133128T2 (de) 1990-04-12 2003-06-18 Syngenta Participations Ag, Basel Gewebe-spezifische Promotoren
US5459252A (en) 1991-01-31 1995-10-17 North Carolina State University Root specific gene promoter
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
US5633363A (en) 1994-06-03 1997-05-27 Iowa State University, Research Foundation In Root preferential promoter
US5837876A (en) 1995-07-28 1998-11-17 North Carolina State University Root cortex specific gene promoter
US5803081A (en) 1996-06-28 1998-09-08 Regent Court Technologies Tobacco and related products
US6135121A (en) 1996-06-28 2000-10-24 Regent Court Technologies Tobacco products having reduced nitrosamine content
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
SE9803986D0 (sv) * 1998-11-23 1998-11-23 Pharmacia & Upjohn Ab New compositions
WO2000052168A1 (en) 1999-02-26 2000-09-08 Cropdesign N.V. Method of selecting transformed cells and tissues
US6805134B2 (en) 1999-04-26 2004-10-19 R. J. Reynolds Tobacco Company Tobacco processing
FR2795424B1 (fr) 1999-06-25 2003-12-05 Agronomique Inst Nat Rech Promoteur s'exprimant specifiquement dans les cellules de racines de plantes, vecteurs et cellules hotes recombinantes comprenant un tel promoteur et plantes transgeniques obtenues
US6723896B1 (en) 1999-11-12 2004-04-20 The Rockefeller University Inducible site-specific recombination for the activation and removal of transgenes in transgenic plants
WO2001059086A2 (en) 2000-02-08 2001-08-16 Sakata Seed Corporation Methods and constructs for agrobacterium-mediated plant transformation
AU2002230691A1 (en) 2000-11-07 2002-05-21 North Carolina State University Putrescine-n-methyltransferase promoter
AU2002228901A1 (en) 2000-11-10 2002-05-21 Vector Tobacco (Bermuda) Ltd. Method and product for removing carcinogens from tobacco smoke
WO2003013226A2 (en) 2001-08-09 2003-02-20 Cibus Genetics Non-transgenic herbicide resistant plants
AU2002354015B2 (en) 2001-11-07 2007-04-26 Syngenta Participations Ag Promoters for regulation of gene expression in plant roots
US7700834B2 (en) 2001-11-13 2010-04-20 U.S. Smokless Tobacco Company Nicotiana nucleic acid molecules and uses thereof
US7700851B2 (en) 2001-11-13 2010-04-20 U.S. Smokeless Tobacco Company Tobacco nicotine demethylase genomic clone and uses thereof
FR2834212B1 (fr) * 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
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BRPI0307791B1 (pt) 2002-02-20 2020-08-11 J.R. Simplot Company Métodos para modificar característica de planta selecionada
CA2481167A1 (en) 2002-04-09 2003-10-23 Vector Tobacco Ltd. Tobacco having reduced nicotine and nitrosamines
ES2285233T3 (es) * 2002-12-20 2007-11-16 Niconovum Ab Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable.
WO2004068973A2 (en) 2003-01-31 2004-08-19 Philip Morris Products S.A. Spray and/or soil treatment of tobacco to reduce tsnas
WO2004076625A2 (en) 2003-02-21 2004-09-10 Vector Tobacco Ltd. Method of identifying plant cells transformed with a gene
AU2004266694A1 (en) 2003-08-19 2005-03-03 22Nd Century Limited, Llc Reduced-exposure tobacco products
US7411112B2 (en) 2003-10-09 2008-08-12 Pioneer Hi-Bred International, Inc. Maize promoter named CRWAQ81
EP1851317B1 (en) 2005-02-23 2011-10-26 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes
JP4892744B2 (ja) * 2005-02-28 2012-03-07 国立大学法人 奈良先端科学技術大学院大学 植物におけるニコチン類縁アルカロイド量を低下させる方法

Also Published As

Publication number Publication date
PL2450446T3 (pl) 2015-10-30
TWI659102B (zh) 2019-05-11
TW201623611A (zh) 2016-07-01
TW201925466A (zh) 2019-07-01
EP2450446A2 (en) 2012-05-09
TWI657141B (zh) 2019-04-21
EP2061889A2 (en) 2009-05-27
HK1203545A1 (en) 2015-10-30
PL2792750T3 (pl) 2020-02-28
TWI421341B (zh) 2014-01-01
EP2792750B1 (en) 2019-07-03
HK1169677A1 (en) 2013-02-01
JP5087777B2 (ja) 2012-12-05
HUE026819T2 (en) 2016-07-28
TW200817509A (en) 2008-04-16
ES2478633T3 (es) 2014-07-22
EP2792750A1 (en) 2014-10-22
PL2061889T3 (pl) 2014-11-28
TW201414834A (zh) 2014-04-16
JP2010505449A (ja) 2010-02-25
EP2450446A3 (en) 2012-07-11
ES2748823T3 (es) 2020-03-18
EP2450446B1 (en) 2015-04-29
WO2007072224A3 (en) 2008-04-17
ES2543907T3 (es) 2015-08-25
WO2007072224A2 (en) 2007-06-28
EP3578661A1 (en) 2019-12-11
EP2061889B1 (en) 2014-04-23
WO2007072224A8 (en) 2009-04-23

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