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RS20060004A - Pyrrolo/3,4-c/pyrazole derivatives active as kinase inhibitors - Google Patents

Pyrrolo/3,4-c/pyrazole derivatives active as kinase inhibitors

Info

Publication number
RS20060004A
RS20060004A YUP-2006/0004A YUP20060004A RS20060004A RS 20060004 A RS20060004 A RS 20060004A YU P20060004 A YUP20060004 A YU P20060004A RS 20060004 A RS20060004 A RS 20060004A
Authority
RS
Serbia
Prior art keywords
pyrrolo
pyrazole derivatives
kinase inhibitors
derivatives active
active
Prior art date
Application number
YUP-2006/0004A
Other languages
English (en)
Inventor
Mario Varasi
Daniele Fancelli
Barbara Forte
Jurgen Moll
Paola Vianello
Original Assignee
Pharmacia Italia S.P.A.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia S.P.A., filed Critical Pharmacia Italia S.P.A.,
Publication of RS20060004A publication Critical patent/RS20060004A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Opisani su pirolo[3,4-c ]pirazolo derivati formule (I) i njihove farmaceutski prihvatljive soli, kao što je definisano u specifikaciju, procesi za njihovu pripremu i farmaceutski preparati koji ih sadrže; jedinjenja pronalaska su mogu koristiti, u terapiji, u lečenju oboljenja koja su povezana sa nepravilnom aktivnošću protein kinaze, kao što je kancer
YUP-2006/0004A 2003-07-09 2004-07-08 Pyrrolo/3,4-c/pyrazole derivatives active as kinase inhibitors RS20060004A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48581403P 2003-07-09 2003-07-09
PCT/EP2004/007515 WO2005005427A1 (en) 2003-07-09 2004-07-08 PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
RS20060004A true RS20060004A (en) 2008-06-05

Family

ID=34062099

Family Applications (2)

Application Number Title Priority Date Filing Date
YUP-2006/0004A RS20060004A (en) 2003-07-09 2004-07-08 Pyrrolo/3,4-c/pyrazole derivatives active as kinase inhibitors
RS20060004A RS52155B (sr) 2003-07-09 2004-07-08 DERIVATI PIROLO(3,4-c)PIRAZOLA AKTIVNI KAO INHIBITORI KINAZE

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20060004A RS52155B (sr) 2003-07-09 2004-07-08 DERIVATI PIROLO(3,4-c)PIRAZOLA AKTIVNI KAO INHIBITORI KINAZE

Country Status (41)

Country Link
US (2) US7141568B2 (sr)
EP (1) EP1644376B1 (sr)
JP (1) JP4728232B2 (sr)
KR (1) KR101075711B1 (sr)
CN (1) CN100564380C (sr)
AP (1) AP2214A (sr)
AR (1) AR050045A1 (sr)
AT (1) ATE480540T1 (sr)
AU (1) AU2004255347B2 (sr)
BR (1) BRPI0411868B8 (sr)
CA (1) CA2531759C (sr)
CR (1) CR8171A (sr)
CY (1) CY1110832T1 (sr)
DE (1) DE602004029045D1 (sr)
DK (1) DK1644376T3 (sr)
DO (1) DOP2004000949A (sr)
EA (1) EA009462B1 (sr)
EC (1) ECSP056246A (sr)
ES (1) ES2349780T3 (sr)
GE (1) GEP20084395B (sr)
GT (2) GT200400133AA (sr)
HN (1) HN2004000232A (sr)
IL (1) IL172923A (sr)
IS (1) IS2843B (sr)
MA (1) MA28064A1 (sr)
ME (1) MEP51908A (sr)
MX (1) MXPA06000362A (sr)
MY (1) MY139072A (sr)
NO (1) NO332361B1 (sr)
NZ (1) NZ544514A (sr)
PA (1) PA8606201A1 (sr)
PE (1) PE20050325A1 (sr)
PL (1) PL1644376T3 (sr)
PT (1) PT1644376E (sr)
RS (2) RS20060004A (sr)
SI (1) SI1644376T1 (sr)
TN (1) TNSN06009A1 (sr)
TW (1) TWI343382B (sr)
UA (1) UA81682C2 (sr)
WO (1) WO2005005427A1 (sr)
ZA (1) ZA200600095B (sr)

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WO2005061519A1 (en) * 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
US20050250829A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Kinase inhibitors
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DE602005023333D1 (de) 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
ES2365245T3 (es) * 2005-01-10 2011-09-27 Pfizer, Inc. Pirrolopirazoles, potentes inhibidores de quinasas.
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
TW200808311A (en) * 2006-03-30 2008-02-16 Nerviano Medical Sciences Srl Use of a kinase inhibitor for the treatment of particular resistant tumors
WO2008017465A1 (en) * 2006-08-10 2008-02-14 F. Hoffmann-La Roche Ag Bicyclic lactam derivatives, their manufacture and use as pharmaceutical agents
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
MX2009003793A (es) 2006-10-09 2009-12-14 Takeda Pharmaceutical Inhibidores de cinasa.
EA200970444A1 (ru) * 2006-11-03 2009-12-30 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Способ введения противоопухолевого соединения
CL2009001158A1 (es) * 2008-05-15 2009-10-23 Nerviano Medical Sciences Srl Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer.
ES2703739T3 (es) * 2008-07-24 2019-03-12 Nerviano Medical Sciences Srl Combinación terapéutica que comprende un inhibidor aurora cinasa y un agente antineoplásico
US20100022553A1 (en) * 2008-07-24 2010-01-28 Nerviano Medical Sciences S.R.L. Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib
ES2415907T3 (es) 2008-07-24 2013-07-29 Nerviano Medical Sciences S.R.L. Combinación terapéutica que comprende un inhibidor de cinasas aurora y agentes antiproliferativos
ES2468391T3 (es) 2008-12-22 2014-06-16 Millennium Pharmaceuticals, Inc. Combinación de inhibidores de cinasas Aurora y anticuerpos anti-CD20
EP2791138B1 (en) 2011-12-12 2018-06-06 Dr. Reddy's Laboratories Ltd. Substituted pyrazolo[1,5-a]pyridine as tropomyosin receptor kinase (trk) inhibitors
CN104072498B (zh) * 2013-03-26 2016-12-28 沈阳药科大学 （R）‑N‑[5‑(2‑甲氧基‑2‑苯基乙酰基)‑1,4,5,6‑四氢吡咯并[3,4‑c]吡唑‑3‑基]‑4‑(4‑甲基哌嗪‑1‑基)苯甲酰胺的合成方法
JP6525474B2 (ja) 2013-12-06 2019-06-05 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼ阻害剤と抗ｃｄ３０抗体の併用
WO2015200341A1 (en) 2014-06-23 2015-12-30 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
EP3309163A4 (en) * 2015-06-15 2019-01-09 UBE Industries, Ltd. SUBSTITUTED DIHYDROPYRROLO PYRAZOL DERIVATIVE
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
CN107337674B (zh) * 2016-04-29 2019-09-20 江苏吉贝尔药业股份有限公司 用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途
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Also Published As

Publication number Publication date
BRPI0411868B8 (pt) 2021-05-25
GT200400133AA (es) 2007-07-10
EA009462B1 (ru) 2007-12-28
US20050032839A1 (en) 2005-02-10
JP4728232B2 (ja) 2011-07-20
GEP20084395B (en) 2008-06-10
NO332361B1 (no) 2012-09-03
MEP51908A (en) 2011-05-10
CY1110832T1 (el) 2015-06-10
PT1644376E (pt) 2010-09-24
UA81682C2 (en) 2008-01-25
PL1644376T3 (pl) 2011-03-31
ES2349780T3 (es) 2011-01-11
ECSP056246A (es) 2006-04-19
NZ544514A (en) 2009-07-31
ZA200600095B (en) 2007-01-31
CR8171A (es) 2006-08-09
TWI343382B (en) 2011-06-11
WO2005005427A1 (en) 2005-01-20
HN2004000232A (es) 2011-01-17
MY139072A (en) 2009-08-28
IL172923A0 (en) 2006-06-11
KR20060033001A (ko) 2006-04-18
EP1644376B1 (en) 2010-09-08
AU2004255347A1 (en) 2005-01-20
MXPA06000362A (es) 2006-03-28
PA8606201A1 (es) 2005-08-04
AP2214A (en) 2011-03-04
KR101075711B1 (ko) 2011-10-21
DOP2004000949A (es) 2005-01-15
US7582628B2 (en) 2009-09-01
GT200400133A (es) 2005-04-18
TNSN06009A1 (fr) 2007-10-03
TW200510385A (en) 2005-03-16
CA2531759A1 (en) 2005-01-20
PE20050325A1 (es) 2005-05-17
CN1820009A (zh) 2006-08-16
CN100564380C (zh) 2009-12-02
IS2843B (is) 2013-08-15
US20060276471A1 (en) 2006-12-07
AU2004255347B2 (en) 2010-04-08
AP2006003480A0 (en) 2006-02-28
JP2009513525A (ja) 2009-04-02
RS52155B (sr) 2012-08-31
MA28064A1 (fr) 2006-08-01
BRPI0411868A (pt) 2006-08-08
NO20060113L (no) 2006-04-05
DK1644376T3 (da) 2011-01-03
IL172923A (en) 2011-09-27
CA2531759C (en) 2013-04-02
SI1644376T1 (sl) 2010-11-30
HK1089769A1 (en) 2006-12-08
EA200600209A1 (ru) 2006-06-30
DE602004029045D1 (de) 2010-10-21
ATE480540T1 (de) 2010-09-15
EP1644376A1 (en) 2006-04-12
BRPI0411868B1 (pt) 2019-11-12
IS8192A (is) 2005-12-22
AR050045A1 (es) 2006-09-27
US7141568B2 (en) 2006-11-28

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