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SA518392101B1 - ROR-Gamma مشتقات البنزيميدازول في صورة مُعدلات لـ - Google Patents

ROR-Gamma مشتقات البنزيميدازول في صورة مُعدلات لـ

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Publication number
SA518392101B1
SA518392101B1 SA518392101A SA518392101A SA518392101B1 SA 518392101 B1 SA518392101 B1 SA 518392101B1 SA 518392101 A SA518392101 A SA 518392101A SA 518392101 A SA518392101 A SA 518392101A SA 518392101 B1 SA518392101 B1 SA 518392101B1
Authority
SA
Saudi Arabia
Prior art keywords
ror
modulators
gamma
benzimidazole derivatives
diseases
Prior art date
Application number
SA518392101A
Other languages
English (en)
Inventor
ايه كلاريمون ديفيد
دي لوتيستا ستيفن
بي سينغ سوريش
ام تيس كولين
واين ديلارد لورانس
زهوانج لينجهانج
زهاو وي
فان يي
Original Assignee
فيتاي فارماكيوتيكالز، أل أل سي
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by فيتاي فارماكيوتيكالز، أل أل سي filed Critical فيتاي فارماكيوتيكالز، أل أل سي
Publication of SA518392101B1 publication Critical patent/SA518392101B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

تُقدَّم هنا مركبات جديدة تحمل الصيغة (I) (I) وأملاحها المقبولة صيدلانيًا وتركيباتها المقبولة صيدلانيًا، والتي تكون مفيدة في علاج الأمراض والاضطرابات treatment of diseases and disorders التي يلعب فيها مستقبل RORγ دورًا وسيطًا. كما تُتاحُ أيضًا تركيبات صيدلانية تتألف من مركبات جديدة تحمل الصيغة I وطرق لاستخدامها في علاج مرض أو اضطراب واحد أو أكثر من الأمراض الالتهابية inflammatory والأيضية metabolic وذاتية المناعة autoimmune وغيرها.
SA518392101A 2016-01-29 2018-07-28 ROR-Gamma مشتقات البنزيميدازول في صورة مُعدلات لـ SA518392101B1 (ar)

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RU2760366C2 (ru) 2021-11-24
EP3408268A1 (en) 2018-12-05
MA55328A (fr) 2022-01-19
JP6948333B2 (ja) 2021-10-13
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US10829481B2 (en) 2020-11-10
TW202220968A (zh) 2022-06-01
MX381313B (es) 2025-03-12
BR112018015273A2 (pt) 2018-12-18
WO2017132432A8 (en) 2017-08-31
KR20180100697A (ko) 2018-09-11
MX2018009257A (es) 2018-11-09
CN114230523A (zh) 2022-03-25
CA3011838A1 (en) 2017-08-03
US20210094940A1 (en) 2021-04-01
AU2017212577B2 (en) 2021-05-13
UY37098A (es) 2017-08-31
MA45646A (fr) 2021-03-24
CN109071509A (zh) 2018-12-21
EP3939974A1 (en) 2022-01-19
TWI757266B (zh) 2022-03-11
RU2018127360A3 (ar) 2020-04-06
TW201734001A (zh) 2017-10-01
EP3408268B1 (en) 2021-08-04
JP2019503385A (ja) 2019-02-07
RU2018127360A (ru) 2020-03-02
WO2017132432A1 (en) 2017-08-03
AU2017212577A1 (en) 2018-08-02
US20190352286A1 (en) 2019-11-21

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