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SG11201408821SA - Selective pi3k delta inhibitors - Google Patents

Selective pi3k delta inhibitors

Info

Publication number
SG11201408821SA
SG11201408821SA SG11201408821SA SG11201408821SA SG11201408821SA SG 11201408821S A SG11201408821S A SG 11201408821SA SG 11201408821S A SG11201408821S A SG 11201408821SA SG 11201408821S A SG11201408821S A SG 11201408821SA SG 11201408821S A SG11201408821S A SG 11201408821SA
Authority
SG
Singapore
Prior art keywords
international
rhizen
courvoisier
fonds
chaux
Prior art date
Application number
SG11201408821SA
Inventor
Swaroop Kumar Venkata Satya Vakkalanka
Meyyappan Muthuppalaniappan
Dhanapalan Nagarathnam
Original Assignee
Rhizen Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54193752&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201408821S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhizen Pharmaceuticals Sa filed Critical Rhizen Pharmaceuticals Sa
Publication of SG11201408821SA publication Critical patent/SG11201408821SA/en

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/006572 A1 (51) International Patent Classification: C07D 487/04 (2006.01) A61P 35/00 (2006.01) A61K31/519 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 2692/CHE/2012 2693/CHE/2012 61/691,561 61/691,586 4 July 2012 (04.07.2012) 4 July 2012 (04.07.2012) 21 August 2012 (21.08.2012) 21 August 2012 (21.08.2012) PCT/IB2013/055434 2 July 2013 (02.07.2013) English English IN IN US US (71) Applicant: RHIZEN PHARMACEUTICALS SA [CH/CH]; Fritz Courvoisier 40, CH-2300 La Chaux de Fonds (CH). (72) Inventors: VAKKALANKA, Swaroop Kumar Venkata Satya; c/o Rhizen Pharmaceuticals SA, Fritz Courvoisier 40, CH-2300 La Chaux de Fonds (CH). MUTHUPPA- LANIAPPAN, Meyyappan; No.4, Sir C.V Raman Street, Rajajipuram, Thiruvallur, Thivalur district, Tamil Nadu 602001 (IN). NAGARATHNAM, Dhanapalan; c/o Rhizen Pharmaceuticals SA, Fritz Courvoisier 40, CH- 2300 La Chaux de Fonds (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) CJ l> o o o CJ (54) Title: SELECTIVE PI3K DELTA INHIBITORS (57) Abstract: The present invention relates to selective inhibitors of PI3K delta protein kinases having a lH-pyrazolo[3,4- d]pyrimidine ring system, methods of preparing them, pharmaceutical compositions containing them and methods of treatment and/or prevention of kinase mediated diseases or disorders with them.
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA036876B1 (en) 2009-11-05 2020-12-30 Ризен Фармасьютикалз С.А. Pi3k kinase inhibitors
SI2705029T1 (en) 2011-05-04 2019-03-29 Rhizen Pharmaceuticals S.A. Novel compounds as modulators of protein kinases
SI2844647T1 (en) * 2012-05-04 2020-12-31 Rhizen Pharmaceuticals S.A. Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
US10130635B2 (en) 2012-05-04 2018-11-20 Rhizen Pharmaceuticals Sa Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
DK3260455T3 (en) * 2012-07-04 2019-06-11 Rhizen Pharmaceuticals S A SELECTIVE PI3K DELTA REQUESTS
WO2014071125A1 (en) * 2012-11-02 2014-05-08 Tg Therapeutics, Inc. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor
CA2914284A1 (en) 2013-05-30 2014-12-04 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
PT3119397T (en) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
PL3149000T3 (en) 2014-05-27 2021-11-02 Rhizen Pharmaceuticals S.A. Crystalline tosylate salt of a pi3k delta selective inhibitor for use in pharmaceutical formulations
US9708329B2 (en) * 2014-06-27 2017-07-18 Rhizen Pharmaceuticals Sa Selective dual inhibitors of PI3 delta and gamma protein kinases
US9944639B2 (en) 2014-07-04 2018-04-17 Lupin Limited Quinolizinone derivatives as PI3K inhibitors
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN114230571B (en) 2015-09-14 2025-07-08 无限药品股份有限公司 Solid forms of isoquinolinones, methods of making, compositions comprising, and methods of using the same
US20190070183A1 (en) * 2015-11-04 2019-03-07 The Trustees Of Columbia University In The City Of New York Targeting Casein Kinase-1 and PI3K/AKT/mTOR Pathways for Treatment of c-Myc-Overexpressing Cancers, Organ Transplant Associated Complications and Autoimmune Diseases
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
AU2017256488B2 (en) * 2016-04-29 2020-12-17 Yuhan Corporation Quinazoline derivative or its salt and pharmaceutical composition comprising the same
EP3463318A4 (en) 2016-05-27 2020-01-01 TG Therapeutics Inc. Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20190033526A (en) 2016-06-24 2019-03-29 인피니티 파마슈티칼스, 인코포레이티드 Combination therapy
WO2018002958A1 (en) 2016-06-30 2018-01-04 Sun Pharma Advanced Research Company Limited Novel hydrazide containing compounds as btk inhibitors
CN110191720A (en) 2016-09-09 2019-08-30 Tg治疗有限公司 Combination of anti-CD20 antibody, PI 3-kinase-delta inhibitor, and anti-PD-1 or anti-PD-L1 antibody for the treatment of hematological cancers
JP6934562B2 (en) 2017-08-22 2021-09-15 ギリアード サイエンシーズ， インコーポレイテッド Therapeutic heterocyclic compounds
CN108434150B (en) * 2018-02-09 2020-03-10 天津医科大学总医院 Application of ZSTK474 in preparing medicine for treating EAN
AU2019297362B2 (en) 2018-07-06 2022-05-26 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
US11186579B2 (en) 2018-07-06 2021-11-30 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
CN112601746B (en) 2018-08-21 2022-09-16 南京明德新药研发有限公司 Pyrazolopyrimidine derivatives and their use as PI3K inhibitors
EP3964512A4 (en) * 2019-06-27 2022-08-10 Hangzhou Healzen Therapeutics Co., Ltd. CASEIN KINASE 1epsilon INHIBITOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
CN114127074A (en) * 2019-07-15 2022-03-01 庄信万丰股份有限公司 Amorphous lapachib monotosylate salt
WO2021164789A1 (en) * 2020-02-21 2021-08-26 南京明德新药研发有限公司 Crystal form of pyrazolopyrimidine compound and use thereof
US20220143026A1 (en) 2020-11-12 2022-05-12 Tg Therapeutics, Inc. Triple combination to treat b-cell malignancies
CN114891005B (en) * 2022-03-30 2024-01-19 武汉九州钰民医药科技有限公司 Preparation process of Wupalision p-toluenesulfonate
US11807689B1 (en) 2022-06-01 2023-11-07 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11965032B1 (en) 2022-06-01 2024-04-23 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11884740B1 (en) 2022-06-01 2024-01-30 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
US11814439B1 (en) 2022-06-01 2023-11-14 Tg Therapeutics, Inc. Anti-CD20 antibody compositions

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62201882A (en) 1985-11-18 1987-09-05 Yamanouchi Pharmaceut Co Ltd Isoflavon derivative
JPH08175990A (en) 1994-12-19 1996-07-09 Mitsubishi Chem Corp PI3 kinase inhibitor and method for producing the same
JPH08176070A (en) 1994-12-19 1996-07-09 Mitsubishi Chem Corp Didepside derivative and PI3 kinase inhibitor
GB9521987D0 (en) 1995-10-26 1996-01-03 Ludwig Inst Cancer Res Phosphoinositide 3-kinase modulators
JP2001247477A (en) 2000-03-03 2001-09-11 Teikoku Hormone Mfg Co Ltd Antitumor agent
JP4642309B2 (en) 2000-04-25 2011-03-02 イコス・コーポレイション Inhibitors of human phosphatidyl-inositol 3-kinase delta
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
US6403588B1 (en) 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
DE60203260T2 (en) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford PHARMACEUTICAL COMBINATION CONTAINING A 4-CHINA-ZININAMINE AND PACLITAXEL, CARBOPLATIN OR VINORELBINE FOR THE TREATMENT OF CANCER
EP1417976A4 (en) 2001-07-26 2004-09-15 Santen Pharmaceutical Co Ltd Remedy for glaucoma comprising as the active ingredient compound having pi3 kinase inhibitory effect
US6703414B2 (en) 2001-09-14 2004-03-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Device and method for treating restenosis
WO2003034997A2 (en) 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
US6908932B2 (en) 2001-10-24 2005-06-21 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
JP2005509645A (en) 2001-10-30 2005-04-14 ファルマシア・コーポレーション Heteroaromatic carboxamide derivatives for the treatment of inflammation
AU2003234733B2 (en) 2002-04-17 2009-01-29 Cytokinetics, Inc. Compounds, compositions, and methods
EA011807B1 (en) 2002-07-10 2009-06-30 Лаборатуар Сероно Са Azolidinone-vinyl fused-benzene derivatives
US20040092561A1 (en) 2002-11-07 2004-05-13 Thomas Ruckle Azolidinone-vinyl fused -benzene derivatives
CA2489779A1 (en) 2002-07-10 2004-01-22 Applied Research Systems Ars Holding N.V. Use of compounds for increasing spermatozoa motility
AU2003255845A1 (en) 2002-08-22 2004-03-11 Piramed Limited Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents
US7605155B2 (en) 2002-09-04 2009-10-20 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7601724B2 (en) 2002-09-04 2009-10-13 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
SI2289936T1 (en) 2002-12-16 2017-10-30 Genentech, Inc. Immunoglobulin variants and uses thereof
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
US7414055B2 (en) 2003-04-24 2008-08-19 Merck & Co., Inc. Inhibitors of Akt activity
PE20050338A1 (en) 2003-08-06 2005-05-16 Vertex Pharma AMINOTRIAZOLES COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
WO2005016348A1 (en) 2003-08-14 2005-02-24 Icos Corporation Method of inhibiting immune responses stimulated by an endogenous factor
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
AU2005289644A1 (en) 2004-09-24 2006-04-06 Janssen Pharmaceutica, N.V. Imidazo{4,5-b}pyrazinone inhibitors of protein kinases
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
FR2882751B1 (en) 2005-03-04 2007-09-14 Aventis Pharma Sa HYDRAZINOCARBONYL-THIENO [2,3-C] PYRAZOLES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
JP2009500418A (en) 2005-07-08 2009-01-08 メルク エンド カムパニー インコーポレーテッド Inhibitor of checkpoint kinase
KR20080035698A (en) 2005-08-16 2008-04-23 아이알엠 엘엘씨 Compounds and Compositions as Protein Kinase Inhibitors
DE602006011192D1 (en) 2005-09-06 2010-01-28 Smithkline Beecham Corp BENZIMIDAZOLTHIOPHIC COMPOUNDS AS PLK INHIBITORS
NZ594628A (en) 2005-10-07 2013-04-26 Exelixis Inc PYRIDOPYRIMIDINONE INHIBITORS OF PI3Ka
GB0520657D0 (en) 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
CA2624676A1 (en) 2005-10-21 2007-05-03 Jongwon Lim Tyrosine kinase inhibitors
EP1981884B1 (en) 2006-01-18 2012-06-13 Amgen, Inc Thiazole compounds as protein kinase b (pkb) inhibitors
EP1994023A1 (en) 2006-03-02 2008-11-26 AstraZeneca AB Quinazoline derivatives
EP1999135A2 (en) 2006-03-30 2008-12-10 Takeda San Diego, Inc. Kinase inhibitors
PT2024372E (en) 2006-04-26 2010-09-16 Hoffmann La Roche Thieno[3,2-d]pyrimidine derivative useful as pi3k inhibitor
BRPI0710908A2 (en) 2006-04-26 2012-06-26 Genentech Inc phosphoinositide 3-kinase inhibiting compounds and pharmaceutical compositions containing them
CA2652328A1 (en) 2006-05-15 2007-11-22 Takeda Pharmaceutical Company Limited Prophylactic and therapeutic agent for cancer
GB0610243D0 (en) 2006-05-23 2006-07-05 Novartis Ag Organic compounds
US20090263398A1 (en) 2006-07-14 2009-10-22 Astex Therapeutics Limited Pharmaceutical combinations
WO2008021859A1 (en) 2006-08-09 2008-02-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP2064203A1 (en) 2006-09-14 2009-06-03 AstraZeneca AB 2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
CL2007003520A1 (en) 2006-12-07 2008-08-22 Piramed Ltd Genentech Inc COMPOUNDS DERIVED FROM HETEROCICLES REPLACED WITH MORFOLINA, INHIBITORS OF THE PI3 QUINASA ACTIVITY; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; PHARMACEUTICAL KIT; AND ITS USE FOR CANCER PROFILACTIC OR THERAPEUTIC TREATMENT.
BRPI0717907A2 (en) * 2006-12-07 2013-11-05 Genentech Inc "COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING A CANCER, INHIBITING OR MODULATING LIPID KINASE ACTIVITY, PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND AND KIT"
JP2010526823A (en) 2007-05-10 2010-08-05 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Quinoxaline derivatives as PI3 kinase inhibitors
US20090263397A1 (en) 2007-07-06 2009-10-22 Buck Elizabeth A Combination anti-cancer therapy
WO2009105712A1 (en) 2008-02-22 2009-08-27 Irm Llc Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors
MX2010009445A (en) 2008-02-29 2011-05-25 Cylene Pharmaceuticals Inc Protein kinase modulators.
WO2009111547A1 (en) 2008-03-04 2009-09-11 Wyeth 7h-pyrrolo[2,3-h]quinazoline compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis
AP2651A (en) 2008-03-04 2013-04-25 Natco Pharma Ltd Crystal form of phenylamino pyrimidine derivatives
WO2009111531A1 (en) 2008-03-06 2009-09-11 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
UY31700A (en) 2008-03-13 2009-11-10 Boehringer Ingelheim Int TIAZOLIL-DIHIDRO-INDAZOLES
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
EP2262807B1 (en) 2008-03-19 2015-08-12 ChemBridge Corporation Novel tyrosine kinase inhibitors
EP2276763A1 (en) 2008-03-19 2011-01-26 OSI Pharmaceuticals, Inc. Mtor inhibitor salt forms
WO2009120094A2 (en) 2008-03-27 2009-10-01 Auckland Uniservices Limited Substituted pyrimidines and triazines and their use in cancer therapy
US7928248B2 (en) 2008-03-31 2011-04-19 Genentech, Inc. Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use
US20090258907A1 (en) 2008-04-09 2009-10-15 Abbott Laboratories Compounds useful as inhibitors of rock kinases
EP2297145A2 (en) 2008-04-16 2011-03-23 Takeda Pharmaceutical Company Limited Polymorphs of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n- (1-methylpiperidin-4-yl)-9h-pyrido[2, 3-b]indole-7-carboxamide and methods of use therefor
CA2721434A1 (en) 2008-04-16 2009-10-22 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatidylinositol 3-kinase
SG195655A1 (en) 2008-11-13 2013-12-30 Gilead Calistoga Llc Therapies for hematologic malignancies
SG174529A1 (en) 2009-03-24 2011-10-28 Gilead Calistoga Llc Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
US8546409B2 (en) 2009-04-20 2013-10-01 Gilead Calistoga Llc Methods of treatment for solid tumors
EA036876B1 (en) 2009-11-05 2020-12-30 Ризен Фармасьютикалз С.А. Pi3k kinase inhibitors
WO2012037155A2 (en) 2010-09-13 2012-03-22 Gtx, Inc. Tyrosine kinase inhibitors
SI2705029T1 (en) * 2011-05-04 2019-03-29 Rhizen Pharmaceuticals S.A. Novel compounds as modulators of protein kinases
DK3260455T3 (en) * 2012-07-04 2019-06-11 Rhizen Pharmaceuticals S A SELECTIVE PI3K DELTA REQUESTS

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