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SG87056A1 - Novel tetrapeptide derivative - Google Patents

Novel tetrapeptide derivative

Info

Publication number
SG87056A1
SG87056A1 SG9905131A SG1999005131A SG87056A1 SG 87056 A1 SG87056 A1 SG 87056A1 SG 9905131 A SG9905131 A SG 9905131A SG 1999005131 A SG1999005131 A SG 1999005131A SG 87056 A1 SG87056 A1 SG 87056A1
Authority
SG
Singapore
Prior art keywords
chem
tetrapeptide derivative
novel tetrapeptide
novel
derivative
Prior art date
Application number
SG9905131A
Other languages
English (en)
Inventor
Sakakibara Kyoichi
Masaaki Gondo
Miyazaki Koichi
Original Assignee
Teikoku Hormone Mfg Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG87056(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd
Publication of SG87056A1 publication Critical patent/SG87056A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG9905131A 1991-08-09 1992-08-06 Novel tetrapeptide derivative SG87056A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22353491 1991-08-09
JP22539191 1991-08-12

Publications (1)

Publication Number Publication Date
SG87056A1 true SG87056A1 (en) 2002-03-19

Family

ID=26525532

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9905131A SG87056A1 (en) 1991-08-09 1992-08-06 Novel tetrapeptide derivative

Country Status (13)

Country Link
US (2) US6004934A (ja)
EP (2) EP0934950B1 (ja)
JP (1) JP2618597B2 (ja)
KR (2) KR0185440B1 (ja)
AT (2) ATE215962T1 (ja)
AU (2) AU662551B2 (ja)
CA (1) CA2115355C (ja)
DE (2) DE69232552T2 (ja)
DK (2) DK0934950T3 (ja)
ES (2) ES2172069T3 (ja)
GR (1) GR3033397T3 (ja)
SG (1) SG87056A1 (ja)
WO (1) WO1993003054A1 (ja)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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ATE169637T1 (de) * 1992-05-20 1998-08-15 Basf Ag Derivate des dolastatin
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
RU2132334C1 (ru) * 1992-12-16 1999-06-27 Басф Акциенгезельшафт Аналог долостатина
ATE282630T1 (de) * 1993-10-01 2004-12-15 Teikoku Hormone Mfg Co Ltd Dolastatin-derivate
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
ATE196913T1 (de) * 1995-04-21 2000-10-15 Teikoku Hormone Mfg Co Ltd Neuartige peptidderivate
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686445B1 (en) 1997-09-24 2004-02-03 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
JP2001517604A (ja) * 1997-09-24 2001-10-09 アリゾナ ボード オブ リーゼンツ ドラスタチン１５から誘導された合成アンチネオプラスチック剤とその製造方法
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
AU1730701A (en) * 1999-12-07 2001-06-18 Santen Pharmaceutical Co. Ltd. Rheumatism remedy containing tetrapeptide derivative as active ingredient
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
KR20010079252A (ko) * 2001-06-27 2001-08-22 홍진의 주름형 드럼을 갖는 드럼 필터
US7008928B2 (en) * 2001-09-20 2006-03-07 Teikoku Hormone Mfg. Co., Ltd. Tetrapeptide derivative TZT-1027 crystal
DK2357006T3 (en) 2002-07-31 2015-12-21 Seattle Genetics Inc Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
CA3062320C (en) * 2003-11-06 2022-11-15 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
WO2006132670A2 (en) * 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the n terminus
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
JP5171621B2 (ja) 2005-07-07 2013-03-27 シアトル ジェネティックス， インコーポレイテッド フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en) * 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
MY159563A (en) 2006-05-16 2017-01-13 Pharmascience Inc Iap bir domain binding compounds
EP2176295B1 (en) 2007-07-16 2014-11-19 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
SI2474557T1 (sl) 2007-07-16 2014-12-31 Genentech, Inc. Protiteles proti CD79b in imunokonjugati in postopki za uporabo
US20090035848A1 (en) * 2007-08-03 2009-02-05 Robert Hickey Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
AR070168A1 (es) 2008-01-31 2010-03-17 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados y metodos de uso de los mismos
ES2523033T3 (es) 2008-03-18 2014-11-20 Seattle Genetics, Inc. Conjugados enlazadores del fármaco auriestatina
SG182724A1 (en) 2010-02-12 2012-08-30 Pharmascience Inc Iap bir domain binding compounds
MY168297A (en) 2011-11-17 2018-10-23 Pfizer Cytotoxic Peptides and Antibody Drug Conjugates Thereof
JP6089108B2 (ja) * 2012-09-20 2017-03-01 セルトリオン， インク． ドラスタチン１０誘導体、その製造方法およびそれを含む抗癌剤組成物
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
EP3082877B1 (en) 2013-12-17 2019-08-28 Novartis AG Cytotoxic peptides and conjugates thereof
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
RU2747989C2 (ru) * 2014-05-28 2021-05-18 Эдженсис, Инк. Производные пептидов долапроин-долаизолейина
EA201692530A1 (ru) 2014-06-13 2017-07-31 Новартис Аг Цитотоксические пептиды и их конъюгаты
LT3262071T (lt) 2014-09-23 2020-06-25 F. Hoffmann-La Roche Ag Anti-cd79b imunokonjugatų naudojimo būdai
CA2989269C (en) 2015-06-15 2020-09-22 Robert Yongxin Zhao Hydrophilic linkers for conjugation of a cytotoxic agent or chromophore molecule to a cell-binding molecule
JP6759326B2 (ja) 2015-07-12 2020-09-23 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 細胞結合分子の共役のための架橋連結体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10435435B2 (en) 2015-07-24 2019-10-08 The Arizona Board Of Regents On Behalf Of Arizona State University Quinstatin compounds
US10722593B2 (en) 2015-10-02 2020-07-28 Sirenas Llc Anti-cancer compounds and conjugates thereof
PL3438118T3 (pl) * 2016-03-29 2023-07-10 Toray Industries, Inc. Pochodna peptydu i jej zastosowanie
KR102459469B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
EP4051691B1 (en) * 2019-10-28 2025-02-12 Ariel Scientific Innovations Ltd. Dolastatin 10 analog
JPWO2023033129A1 (ja) 2021-09-03 2023-03-09
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US6034065A (en) * 1992-12-03 2000-03-07 Arizona Board Of Regents Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10

Also Published As

Publication number Publication date
GR3033397T3 (en) 2000-09-29
AU2001095A (en) 1995-07-20
EP0598129A1 (en) 1994-05-25
US5654399A (en) 1997-08-05
EP0934950A1 (en) 1999-08-11
ATE215962T1 (de) 2002-04-15
AU2415292A (en) 1993-03-02
ES2144421T3 (es) 2000-06-16
EP0934950B1 (en) 2002-04-10
EP0598129B1 (en) 2000-03-22
ES2172069T3 (es) 2002-09-16
AU662551B2 (en) 1995-09-07
AU673487B2 (en) 1996-11-07
CA2115355C (en) 2007-09-11
DE69230824T2 (de) 2000-07-27
JP2618597B2 (ja) 1997-06-11
ATE190983T1 (de) 2000-04-15
WO1993003054A1 (en) 1993-02-18
CA2115355A1 (en) 1993-02-18
DE69230824D1 (de) 2000-04-27
DE69232552T2 (de) 2002-10-31
DK0598129T3 (da) 2000-07-03
KR0185440B1 (ko) 1999-04-01
DE69232552D1 (de) 2002-05-16
EP0598129A4 (en) 1995-10-25
DK0934950T3 (da) 2002-07-29
KR100202474B1 (en) 1999-06-15
US6004934A (en) 1999-12-21

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