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SK281822B6 - Deriváty 4-oxo-2-tioxoimidazolidínu, spôsob ich výroby a farmaceutický prostriedok s ich obsahom - Google Patents

Deriváty 4-oxo-2-tioxoimidazolidínu, spôsob ich výroby a farmaceutický prostriedok s ich obsahom

Info

Publication number
SK281822B6
SK281822B6 SK1072-94A SK107294A SK281822B6 SK 281822 B6 SK281822 B6 SK 281822B6 SK 107294 A SK107294 A SK 107294A SK 281822 B6 SK281822 B6 SK 281822B6
Authority
SK
Slovakia
Prior art keywords
oxo
production
pharmaceutical composition
composition containing
thioxoimidazolidine
Prior art date
Application number
SK1072-94A
Other languages
English (en)
Other versions
SK107294A3 (en
Inventor
Gerhard Zoller
Bernd Jablonka
Jochen Knolle
Melitta Just
Wolfgang König
Original Assignee
Cassella Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Ag filed Critical Cassella Ag
Publication of SK107294A3 publication Critical patent/SK107294A3/sk
Publication of SK281822B6 publication Critical patent/SK281822B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Zlúčeniny všeobecného vzorca (I), v ktorom Y znamená -(CH2)m-CO-, kde m je 1 až 4, alebo skupinu -C6H4-CO-, R1 znamená skupinu -(CH2)n-NH-X, kde n je 1 až 6, -(CH2)p-C6H4-NH-X, -(CH2)p-C6H4-C(=NH)-NH2 alebo -(CH2)p-C6H4-CH2-NH-X, kde p je 1 alebo 2, a X znamená H, C(1-6)-alkyl alebo skupinu všeobecného vzorca (II), pričom R' a R'' znamenajú H alebo C(1-6)alkyl, R2 znamená H alebo C(1-6)-alkyl, R3 znamená H alebo fenyl, R4 znamená H alebo -CO-NH-R5 a -NH-R5 znamená zvyšok alfa-aminokyseliny alebo jeho CO-C(2-8)-alkylamid, ich fyziologicky prijateľné soli, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie ako inhibítorov agregácie trombocytov, metastázovania karcinomových buniek alebo väzby osteoklastov na povrch kostí.
SK1072-94A 1992-03-07 1993-02-24 Deriváty 4-oxo-2-tioxoimidazolidínu, spôsob ich výroby a farmaceutický prostriedok s ich obsahom SK281822B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4207254A DE4207254A1 (de) 1992-03-07 1992-03-07 4-oxo-2-thioxoimidazolidin-derivate
PCT/EP1993/000424 WO1993018057A1 (de) 1992-03-07 1993-02-24 4-oxo-thioxoimidazolidin-derivate als hemmstoffe der blutplättchenaggregation

Publications (2)

Publication Number Publication Date
SK107294A3 SK107294A3 (en) 1995-04-12
SK281822B6 true SK281822B6 (sk) 2001-08-06

Family

ID=6453475

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1072-94A SK281822B6 (sk) 1992-03-07 1993-02-24 Deriváty 4-oxo-2-tioxoimidazolidínu, spôsob ich výroby a farmaceutický prostriedok s ich obsahom

Country Status (16)

Country Link
EP (1) EP0629211B1 (sk)
JP (1) JP3495369B2 (sk)
KR (1) KR100278532B1 (sk)
AT (1) ATE169634T1 (sk)
AU (1) AU665617B2 (sk)
CA (1) CA2130174C (sk)
CZ (1) CZ286327B6 (sk)
DE (2) DE4207254A1 (sk)
DK (1) DK0629211T3 (sk)
ES (1) ES2121993T3 (sk)
HU (1) HU217430B (sk)
IL (1) IL104960A (sk)
SK (1) SK281822B6 (sk)
TW (1) TW255888B (sk)
WO (1) WO1993018057A1 (sk)
ZA (1) ZA931537B (sk)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228717A1 (de) * 1992-08-28 1994-03-03 Cassella Ag Imidazolidin-Derivate
DE4427979A1 (de) * 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
US5554607A (en) * 1995-11-28 1996-09-10 American Home Products Corporation Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis
US5821372A (en) * 1995-11-28 1998-10-13 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
US5599829A (en) * 1995-11-28 1997-02-04 American Home Products Corporation 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives for increasing HDL cholesterol levels
TW418195B (en) * 1995-11-28 2001-01-11 American Home Prod 2-thioxo-imidazolidin-4-one derivatives
DK0796855T3 (da) 1996-03-20 2002-05-27 Hoechst Ag Hæmmere af knogleresorption og vitronectin-receptorantagonister
RU2195460C2 (ru) * 1996-03-20 2002-12-27 Хехст АГ Новые ингибиторы рассасывания костей и антагонисты рецептора витронектина
DE19629817A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19629816A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US5861517A (en) * 1996-11-21 1999-01-19 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
US5663363A (en) * 1996-11-21 1997-09-02 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19922462A1 (de) 1999-05-17 2000-11-23 Aventis Pharma Gmbh Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
TWI339093B (en) 2007-08-24 2011-03-11 Asustek Comp Inc Cellular phone with shiftless motion function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970225A (en) * 1990-02-13 1990-11-13 Bristol-Myers Squibb Company Imidazolidine carboxylic acids and esters as blood platelet aggregation inhibitors
DE4009506A1 (de) * 1990-03-24 1991-09-26 Hoechst Ag Hydantoinderivate

Also Published As

Publication number Publication date
CA2130174A1 (en) 1993-09-16
JP3495369B2 (ja) 2004-02-09
ZA931537B (en) 1993-09-27
HU9402564D0 (en) 1994-11-28
AU3498893A (en) 1993-10-05
WO1993018057A1 (de) 1993-09-16
TW255888B (sk) 1995-09-01
CZ286327B6 (cs) 2000-03-15
EP0629211B1 (de) 1998-08-12
IL104960A0 (en) 1993-07-08
CA2130174C (en) 2003-09-09
CZ216694A3 (en) 1995-04-12
HUT69716A (en) 1995-09-28
IL104960A (en) 1996-12-05
KR950700321A (ko) 1995-01-16
DE4207254A1 (de) 1993-09-09
DK0629211T3 (da) 1999-05-17
DE59308872D1 (de) 1998-09-17
AU665617B2 (en) 1996-01-11
SK107294A3 (en) 1995-04-12
ES2121993T3 (es) 1998-12-16
ATE169634T1 (de) 1998-08-15
EP0629211A1 (de) 1994-12-21
JPH07506567A (ja) 1995-07-20
KR100278532B1 (ko) 2001-01-15
HU217430B (hu) 2000-01-28

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